What are the uses of metoprolol 200 mg. How should metoprolol 200 mg be taken. What are the potential side effects of metoprolol 200 mg. How does metoprolol 200 mg interact with other medications.

Understanding Metoprolol: A Comprehensive Guide

Metoprolol is a widely prescribed medication that belongs to a class of drugs known as beta-blockers. It’s available in two primary forms: metoprolol tartrate (brand name Lopressor) and metoprolol succinate (brand name Toprol XL). Both forms are used to treat various cardiovascular conditions, but they have some distinct differences in their formulation and uses.

Key Differences Between Metoprolol Tartrate and Metoprolol Succinate

• Metoprolol tartrate is an immediate-release formulation
• Metoprolol succinate is an extended-release formulation
• Metoprolol tartrate is typically taken multiple times per day
• Metoprolol succinate is usually taken once daily

Is there a difference in effectiveness between the two forms? While both contain the active ingredient metoprolol, their different salt forms and release mechanisms can make them more suitable for specific conditions or patient needs.

Indications and Uses of Metoprolol 200 mg

Metoprolol 200 mg is a high-strength dosage that is primarily used for treating severe cases of hypertension, angina, and heart failure. The specific uses can vary depending on whether it’s the tartrate or succinate form.

Common Uses for Metoprolol 200 mg

1. Hypertension (high blood pressure)
2. Angina (chest pain)
3. Heart failure (metoprolol succinate)
4. Post-heart attack treatment (metoprolol tartrate)
5. Atrial fibrillation

Can metoprolol 200 mg be used for other conditions? While these are the primary indications, healthcare providers may sometimes prescribe metoprolol for off-label uses, such as migraine prevention or anxiety management.

Mechanism of Action: How Metoprolol Works

Metoprolol exerts its therapeutic effects by blocking the action of norepinephrine (adrenaline) on beta receptors in the body, particularly in the heart and blood vessels. This mechanism leads to several beneficial effects:

• Slowing of heart rate
• Reduction in cardiac output
• Decreased blood pressure
• Reduced oxygen demand of the heart

How does this mechanism translate to clinical benefits? By reducing the workload on the heart and lowering blood pressure, metoprolol can alleviate symptoms of angina, improve heart failure outcomes, and reduce the risk of cardiovascular events in patients with hypertension.

Dosage and Administration of Metoprolol 200 mg

The 200 mg dose of metoprolol is typically reserved for patients who require higher doses to manage their condition effectively. It’s crucial to follow the prescribed dosage and administration instructions carefully.

Metoprolol Succinate ER 200 mg

This extended-release formulation is usually taken once daily. It’s designed to maintain a steady concentration of the drug in the bloodstream over 24 hours.

Metoprolol Tartrate 200 mg

The immediate-release form may be prescribed as 100 mg twice daily, rather than a single 200 mg dose, due to its shorter duration of action.

Should metoprolol be taken with food? Metoprolol can typically be taken with or without food, but it’s best to be consistent with your choice to maintain steady drug levels.

Potential Side Effects of Metoprolol 200 mg

As with all medications, metoprolol can cause side effects. The higher 200 mg dose may increase the likelihood or severity of these effects in some patients.

Common Side Effects

• Fatigue
• Dizziness
• Bradycardia (slow heart rate)
• Gastrointestinal disturbances (diarrhea or constipation)
• Shortness of breath
• Reduced libido

Serious Side Effects

While less common, some patients may experience more severe side effects that require immediate medical attention:

• Severe hypotension (low blood pressure)
• Severe bradycardia
• Cold extremities with pain
• Extreme fatigue
• Depression

Are these side effects more likely with the 200 mg dose? While the incidence of side effects may increase with higher doses, many patients tolerate metoprolol 200 mg well when properly monitored and managed by their healthcare provider.

Drug Interactions with Metoprolol 200 mg

Metoprolol can interact with various medications, potentially altering its effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking.

Notable Drug Interactions

• Other beta-blockers or calcium channel blockers
• Antiarrhythmic drugs
• Certain antidepressants (MAOIs, SSRIs)
• Diphenhydramine and other antihistamines
• NSAIDs (e.g., ibuprofen, naproxen)
• Certain antifungal medications

How can these interactions affect treatment? Some interactions may enhance the blood pressure-lowering effects of metoprolol, potentially leading to severe hypotension. Others may interfere with metoprolol’s metabolism, altering its effectiveness or increasing side effects.

Special Considerations for Metoprolol 200 mg

Certain patient groups may require special attention when prescribed metoprolol 200 mg due to potential risks or altered drug metabolism.

Patients Requiring Extra Caution

• Elderly patients
• Those with liver or kidney impairment
• Diabetics (metoprolol may mask signs of hypoglycemia)
• Patients with chronic lung diseases
• Those scheduled for surgery

Why is caution necessary for these groups? These patients may be more susceptible to the effects of metoprolol or may require dose adjustments to prevent adverse outcomes.

Pregnancy and Breastfeeding

Metoprolol is generally considered pregnancy category C, meaning potential risks cannot be ruled out. It’s also excreted in breast milk. Pregnant or breastfeeding women should discuss the risks and benefits with their healthcare provider.

Monitoring and Follow-up for Metoprolol 200 mg Therapy

Regular monitoring is essential for patients taking metoprolol 200 mg to ensure optimal treatment outcomes and minimize risks.

Key Monitoring Parameters

• Blood pressure
• Heart rate
• Electrocardiogram (ECG)
• Liver and kidney function tests
• Blood glucose levels in diabetic patients

How often should monitoring occur? The frequency of monitoring may vary based on individual patient factors, but typically includes regular check-ups, especially during dose adjustments or when starting therapy.

Signs of Potential Issues

Patients should be educated about signs that may indicate problems with their metoprolol therapy, such as:

• Excessive fatigue or weakness
• Severe dizziness or fainting
• Unusually slow or irregular heartbeat
• Swelling of extremities
• Unexplained weight gain

When should a patient seek immediate medical attention? Any severe or persistent side effects, particularly those affecting heart rate, blood pressure, or breathing, warrant prompt medical evaluation.

Comparative Efficacy of Metoprolol 200 mg vs. Other Beta-Blockers

While metoprolol is a widely used beta-blocker, it’s not the only option available. Understanding how it compares to other medications in its class can help healthcare providers make informed treatment decisions.

Metoprolol vs. Other Common Beta-Blockers

• Atenolol: More cardioselective than metoprolol, but shorter half-life
• Propranolol: Less cardioselective, may have more non-cardiac effects
• Carvedilol: Also blocks alpha receptors, potentially offering additional benefits in heart failure
• Bisoprolol: Highly cardioselective, often used in heart failure

How does metoprolol 200 mg compare in effectiveness? Metoprolol, particularly at higher doses like 200 mg, has shown comparable efficacy to other beta-blockers in managing hypertension and heart failure. Its cardioselectivity and well-established safety profile make it a preferred choice for many clinicians.

Factors Influencing Choice of Beta-Blocker

The selection of metoprolol 200 mg over other beta-blockers may depend on various factors:

• Specific condition being treated
• Patient’s comorbidities
• Potential for drug interactions
• Dosing convenience
• Cost and insurance coverage

Is metoprolol 200 mg always the best choice? While metoprolol is an excellent option for many patients, the best beta-blocker choice varies depending on individual patient factors and treatment goals.

Long-Term Considerations for Metoprolol 200 mg Therapy

For many patients, metoprolol 200 mg is a long-term therapy requiring ongoing management and consideration of potential long-term effects.

Long-Term Benefits

• Sustained blood pressure control
• Reduced risk of cardiovascular events
• Improved heart failure outcomes
• Potential neuroprotective effects

What evidence supports long-term use of metoprolol? Numerous clinical trials have demonstrated the long-term benefits of metoprolol in reducing mortality and morbidity in patients with hypertension, heart failure, and post-myocardial infarction.

Potential Long-Term Concerns

While generally well-tolerated, some patients may experience long-term effects that require monitoring:

• Metabolic changes (e.g., slight increase in triglycerides)
• Potential for masking hypoglycemia in diabetics
• Risk of rebound hypertension if abruptly discontinued
• Possible cognitive effects in some elderly patients

How can these long-term concerns be managed? Regular follow-ups, periodic reassessment of therapy, and patient education about the importance of adherence and gradual dose changes can help mitigate potential long-term issues.

Patient Education and Adherence Strategies for Metoprolol 200 mg

Successful long-term therapy with metoprolol 200 mg relies heavily on patient understanding and adherence to the prescribed regimen.

Key Points for Patient Education

• Importance of consistent timing of doses
• Need for gradual dose changes under medical supervision
• Potential interactions with other medications and substances
• Recognition of side effects requiring medical attention
• Importance of regular follow-up appointments

How can healthcare providers improve patient adherence? Clear communication about the benefits of therapy, addressing patient concerns, and providing tools like pill organizers or reminder apps can enhance adherence.

Strategies to Improve Adherence

1. Use of once-daily extended-release formulations when possible
2. Integration of medication-taking into daily routines
3. Regular blood pressure monitoring at home to reinforce benefits
4. Addressing side effects promptly to prevent discontinuation
5. Involving family members or caregivers in medication management

What role does patient empowerment play in adherence? Educating patients about their condition and the role of metoprolol in its management can increase their sense of control and motivation to adhere to therapy.

Future Directions and Research in Metoprolol Therapy

While metoprolol has been a staple in cardiovascular therapy for decades, ongoing research continues to explore its potential in new applications and refine its use in existing indications.

Emerging Areas of Research

• Role in cancer-related cardiovascular complications
• Potential neuroprotective effects in traumatic brain injury
• Use in managing certain types of arrhythmias
• Combination therapies for enhanced efficacy in resistant hypertension
• Personalized dosing based on genetic factors

How might future research impact the use of metoprolol 200 mg? Ongoing studies may lead to more targeted use of high-dose metoprolol, potentially expanding its indications or refining dosing strategies for specific patient populations.

Evolving Treatment Paradigms

As our understanding of cardiovascular disease continues to grow, the role of beta-blockers like metoprolol may evolve:

• Increased focus on early intervention in high-risk patients
• Greater emphasis on combination therapies for comprehensive cardiovascular risk reduction
• Exploration of beta-blockers in non-cardiovascular conditions
• Development of novel drug delivery systems for improved pharmacokinetics

What implications do these evolving paradigms have for patients currently on metoprolol 200 mg? While metoprolol remains a cornerstone of therapy for many cardiovascular conditions, patients and healthcare providers should stay informed about emerging research that may influence treatment strategies.

In conclusion, metoprolol 200 mg represents a potent therapeutic option in the management of various cardiovascular conditions. Its efficacy, coupled with a well-established safety profile, makes it a valuable tool in the clinician’s armamentarium. However, as with any high-dose medication, careful patient selection, monitoring, and management are crucial to maximizing benefits while minimizing risks. As research continues to unfold, our understanding and utilization of metoprolol may further evolve, potentially opening new avenues for its application in patient care.

Side effects, dosage, uses, and more

1. Metoprolol oral tablet is available as generic drugs and as brand-name drugs. Brand names: Lopressor and Toprol XL.
2. Metoprolol comes as immediate-release and extended-release tablets, and an extended-release capsule. It also comes in an injectable form that’s only given by a healthcare provider.
3. Metoprolol is a drug called a beta-blocker. It’s used to treat conditions such as high blood pressure, heart failure, and angina (chest pain).

Metoprolol is a prescription drug. It comes as immediate-release and extended-release oral tablets, and extended-release oral capsules. It also comes in an injectable form that’s only given by a healthcare provider.

Metoprolol oral tablets are available as the brand-name drugs Lopressor and Toprol XL. They’re also available as generic drugs. Generic drugs usually cost less than the brand-name versions. In some cases, they may not be available in all strengths or forms as the brand-name drugs.

The two brand-name forms of metoprolol (as well as the different generic forms) are different versions of the medication. They’re both metoprolol, but they contain different salt forms. Lopressor is metoprolol tartrate, while Toprol-XL is metoprolol succinate. The different salt forms enable the drugs to be used to treat different conditions.

Metoprolol succinate is an extended-release version of metoprolol, so it remains in your bloodstream for a longer time. Metoprolol tartrate is an immediate-release version of metoprolol.

Why it’s used

Both forms of metoprolol — metoprolol tartrate (Lopressor) and metoprolol succinate (Toprol-XL) — are used to:

• lower high blood pressure
• reduce chest pain (angina)

However, metoprolol tartrate is also used to treat and prevent heart attacks, while metoprolol succinate is also used to treat heart failure.

Metoprolol may be used as part of a combination therapy. That means you may have to take it with hydrochlorothiazide or chlorthalidone.

How it works

Both versions of metoprolol belong to a class of drugs called beta-blockers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Blood pressure is often raised because blood vessels are tightened. This puts a strain on the heart and increases the body’s oxygen demand.

Beta-blockers work by preventing norepinephrine (adrenalin) from acting on beta receptors in blood vessels and in the heart. This causes blood vessels to relax. By relaxing the blood vessels, beta-blockers help to lower the heart rate and decrease the heart’s demand for oxygen. This in turn helps decrease blood pressure and reduce chest pain.

Metoprolol oral tablet can cause certain side effects.

More common side effects

The more common side effects that can occur with metoprolol include:

• tiredness
• dizziness
• diarrhea
• constipation
• breathing problems such as shortness of breath, cough, and wheezing
• bradycardia (heart rate that’s slower than normal)
• reduced interest in sex
• rash

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Low blood pressure (hypotension). Symptoms can include:
  • severe dizziness
  • lightheadedness
  • fainting
• Cold hands and feet. Symptoms can include
  • hands and feet that are cold and may be painful
• Very slow heart rate (severe bradycardia)
• Extreme fatigue. Symptoms can include:
  • feeling more tired than usual
  • tiredness that gets progressively worse each day
• Serious depression. Symptoms can include:
  • continuous feelings of sadness or anxiety
  • feelings of hopelessness or worthlessness
  • lack of interest in hobbies you once enjoyed
  • eating too much or too little
  • trouble concentrating

Metoprolol oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with metoprolol are listed below.

Mental health drugs

Taking metoprolol with reserpine and monoamine oxidase inhibitors (MAOIs) may increase or add to the effects of metoprolol. They may also increase lightheadedness or slow your heart rate more. MAOIs can continue to interact with metoprolol for up to 14 days after taking them. Examples of MAOIs include:

• isocarboxazid
• phenelzine
• selegiline
• tranylcypromine

Heart rhythm drugs

Taking heart rhythm drugs with metoprolol can slow down your heart rate too much. Examples of these drugs include:

• digoxin
• quinidine
• propafenone

Calcium channel blockers

Like metoprolol, these drugs are used to treat high blood pressure and several other heart problems. Combined with metoprolol, calcium channel blockers may slow your heart rate even more. Doctors sometimes use this combination under close supervision.

Examples of calcium channel blockers include:

• amlodipine
• diltiazem
• felodipine
• isradipine
• nicardipine
• nifedipine
• nimodipine
• nisoldipine
• verapamil

Drugs processed in the same way as metoprolol

Drugs used to treat depression and other mood disturbances are processed in your body by the same systems as metoprolol. Using these drugs with metoprolol could increase the levels of metoprolol in your body. Examples of these drugs include:

• fluoxetine
• fluvoxamine
• paroxetine
• sertraline
• bupropion
• clomipramine
• desipramine
• chlorpromazine
• fluphenazine
• haloperidol
• thioridazine

Other drugs that are processed in the body the same way as metoprolol include:

• the antiretroviral ritonavir
• antihistamines, including diphenhydramine
• antimalarial drugs, such as hydroxychoroquine and quinidine
• antifungal drugs, such as terbinafine
• the blood pressure drug hydralazine

These drugs can all increase the level of metoprolol in the body.

Alpha-blockers

Alpha-blockers also lower blood pressure. They may decrease blood pressure too much when combined with metoprolol. Examples of these drugs include:

• reserpine
• alpha-methyldopa
• clonidine
• prazosin

Clonidine must be carefully managed if it’s combined with metoprolol. Stopping the drug suddenly while also taking metoprolol can cause a big jump in blood pressure.

Ergot alkaloids

Ergot alkaloids, such as dihydroergotamine, narrow blood vessels to treat headaches. If you take them at the same time as metoprolol, they may cause dangerous narrowing of blood vessels.

Dipyridamole

Dipyridamole is used for heart testing. Because metoprolol affects your heart rate, you should stop taking it before you’re given dipyridamole to help ensure an accurate test result.

All possible dosages and forms may not be included here. Your dosage, form, and how often you take the drug will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Dosage for high blood pressure

Generic: Metoprolol

• Form: immediate-release oral tablet (metoprolol tartrate)
• Strength: 25 mg, 37. 5 mg, 50 mg, 75 mg, and 100 mg
• Form: extended-release oral tablet (metoprolol succinate)
• Strength: 25 mg, 50 mg, 100 mg, and 200 mg

Brand: Lopressor

• Form: immediate-release oral tablet (metoprolol tartrate)
• Strength: 50 mg and 100 mg

Brand: Toprol XL

• Form: extended-release oral tablet (metoprolol succinate)
• Strength: 25 mg, 50 mg, 100 mg, and 200 mg

Adult dosage (ages 18–64 years)

Immediate-release tablets

• Typical starting dosage: 100 mg daily in a single or divided doses. This may be gradually increased if needed.
• Typical maintenance dosage: 100–450 mg per day.
• Maximum dosage: 450 mg per day.

Extended-release tablets

• Typical starting dosage: 25–100 mg daily in a single dose. This may be gradually increased if needed.
• Maximum dosage: 400 mg per day.

Child dosage (ages 6–17 years)

Extended-release tablets

• Typical starting dosage: 1 mg/kg once daily (maximum initial dose should not exceed 50 mg once daily). This dosage may be gradually increased if needed.
• Maximum dosage: 2 mg/kg (or 200 mg) once daily.

Immediate-release tablets

These tablets are not approved for use in this age group.

Child dosage (ages 0–5 years)

Dosage for people younger than 6 years hasn’t been established.

Senior dosage (ages 65 years and older)

Your body may process this drug more slowly. Your doctor may start you on a lowered dosage so that too much of this drug does not build up in your body. Too much of the drug in your body can be dangerous.

Dosage for angina (chest pain)

Generic: Metoprolol

• Form: immediate-release oral tablet (metoprolol tartrate)
• Strength: 25 mg, 37. 5 mg, 50 mg, 75 mg, and 100 mg
• Form: extended-release oral tablet (metoprolol succinate)
• Strength: 25 mg, 50 mg, 100 mg, and 200 mg

Brand: Lopressor

• Form: immediate-release oral tablet (metoprolol tartrate)
• Strength: 50 mg and 100 mg

Brand: Toprol XL

• Form: extended-release oral tablet (metoprolol succinate)
• Strength: 25 mg, 50 mg, 100 mg, and 200 mg

Adult dosage (ages 18–64 years)

Immediate-release tablets

• Typical starting dosage: 50 mg, taken twice a day. This may be gradually increased as needed.
• Typical maintenance dosage: 100–400 mg per day.
• Maximum dosage: 400 mg per day.

Extended-release tablets

• Typical starting dosage: 100 mg taken once a day. This may be gradually increased if needed.
• Maximum dosage: 400 mg per day.

Child dosage (ages 0–17 years)

Dosage for people younger than 18 years hasn’t been established.

Senior dosage (ages 65 years and older)

Your body may process this drug more slowly. Your doctor may start you on a lowered dosage so that too much of this drug does not build up in your body. Too much of the drug in your body can be dangerous.

Dosage for after a heart attack

Generic: Metoprolol

• Form: immediate-release oral tablet (metoprolol tartrate)
• Strength: 25 mg, 37.5 mg, 50 mg, 75 mg, and 100 mg

Brand: Lopressor

• Form: immediate-release oral tablet (metoprolol tartrate)
• Strength: 50 mg and 100 mg

Adult dosage (ages 18–64 years)

Immediate-release tablets

Treatment with this drug is often started in the hospital with the intravenous formulation as soon as possible after a heart attack. Treatment with the oral medication as noted below is begun if your body tolerates the intravenous dosing.

• Typical starting dosage: 50 mg every 6 hours starting 15 minutes after the last intravenous dose and continuing for 48 hours.
• Typical maintenance dosage: 100 mg twice daily.

Child dosage (ages 0–17 years)

Dosage for people younger than 18 years hasn’t been established.

Senior dosage (ages 65 years and older)

Your body may process this drug more slowly. Your doctor may start you on a lowered dosage so that too much of this drug does not build up in your body. Too much of the drug in your body can be dangerous.

Dosage for heart failure

Generic: Metoprolol

• Form: extended-release oral tablet (metoprolol succinate)
• Strength: 25 mg, 50 mg, 100 mg, and 200 mg

Brand: Toprol XL

• Form: extended-release oral tablet (metoprolol succinate)
• Strength: 25 mg, 50 mg, 100 mg, and 200 mg

Adult dosage (ages 18–64 years)

Extended-release tablets

• Typical starting dosage: For people with NYHA Class II heart failure, it’s 25 mg once daily for 2 weeks. For people with more severe heart failure, it’s 12.5 mg once daily.
• Typical maintenance dosage: Your doctor can double the dosage every 2 weeks to the highest dosage level your body will tolerate, or up to 200 mg per day.

Child dosage (ages 0–17 years)

Dosage for people younger than 18 years hasn’t been established.

Senior dosage (ages 65 years and older)

Your body may process this drug more slowly. Your doctor may start you on a lowered dosage so that too much of this drug does not build up in your body. Too much of the drug in your body can be dangerous.

Special dosage considerations

For people with liver disease: Liver disease may affect your dosage. Your doctor can tell you more.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

FDA warning: Don’t stop taking metoprolol suddenly

• This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
• Don’t stop taking metoprolol suddenly. If you do, you may experience worse chest pain, a jump in blood pressure, or even have a heart attack. Stopping metoprolol is not recommended. If you need to stop taking the drug, first talk to your doctor. Your dosage should be gradually decreased under a doctor’s supervision.

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Allergy warning

This drug can cause a severe allergic reaction. Symptoms can include:

• trouble breathing
• swelling of your throat or tongue

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Warnings for people with certain health conditions

For people with asthma or COPD: Generally, people with asthma or chronic obstructive pulmonary disease (COPD) shouldn’t take metoprolol. A doctor may still prescribe it, but with careful monitoring. At higher doses, metoprolol can block different receptors on the breathing passages. This narrows the passages, which worsens asthma or COPD.

For people with diabetes: Metoprolol may eliminate tremors and reduce heart rate. Tremors and an increased heart rate are signs of low blood sugar. Without these signals, it becomes more difficult to recognize low blood sugar levels.

For people with poor circulation: If you have poor circulation in your feet and hands, it may become worse when taking metoprolol. Because metoprolol reduces blood pressure, you may get even less blood to these parts of your body.

Warnings for other groups

For pregnant women: Metoprolol is a category C pregnancy drug. That means two things:

1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
2. There haven’t been enough studies done in humans.

If you’re pregnant and have high blood pressure, speak with your healthcare provider about your treatment options during pregnancy.

For women who are breastfeeding: Metoprolol enters the breast milk and could be passed to your baby if you breastfeed while taking this drug. Talk to your healthcare provider before breastfeeding.

For seniors: Seniors may need a smaller dosage of metoprolol at first. The dosage may then increase gradually.

For children: The immediate-release form of the drug has not been established as safe or effective in children. The extended-release form of this drug can be used to treat high blood pressure in children 6 years of age or older.

Metoprolol oral tablet can be used either as a short-term drug or a long-term drug. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all: You risk:

• increasing your blood pressure
• damaging your blood vessels or main organs, such as your lungs, heart, or liver
• increasing your risk of a heart attack

Also, if you suddenly stop taking metoprolol for high blood pressure, chest pain, or after a heart attack, you raise your risk of heart attack.

If you miss doses or don’t take the drug on schedule: Not taking metoprolol every day, skipping days, or taking doses at different times of day also come with risks. Your blood pressure might fluctuate too often. That might increase your risk for a heart attack.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• severe low blood pressure
• heart rhythm changes
• nausea
• vomiting

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: If you miss a dose, just take the next dose as planned. Don’t double your dose.

How to tell if the drug is working:

• For high blood pressure or heart failure: You may not be able to tell if this drug is working. Your doctor can do tests to determine if the drug is helping to treat your condition.
• For angina: Your chest pain should be reduced.

Keep these considerations in mind if your doctor prescribes metoprolol oral tablet for you.

General

• Take metoprolol with food. This drug may cause nausea. Taking it with food will allow your stomach to digest it better. Take it either with a meal or right after a meal.
• Don’t crush the extended-release tablet. However, you can cut the tablet along the score marks (the groove on the tablet) if your doctor recommends a smaller dose.
• You can cut the immediate-release tablet.

Storage

• Store at room temperature between 68°F and 77°F (20°C and 25°C). You may briefly store the drug at temperatures as low as 59°F (15°C) and as high as 86°F (30°C).
• Keep this drug away from light.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is not refillable.You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Metoprolol Succinate 24 Hour 24 HR Extended Release Oral Tablet 200 mg

Uses

This medicine is used for the following purposes:

• angina
• heart attack
• heart failure
• high blood pressure
• irregular heart beat
• prevent migraine headaches
• movement disorder

Instructions

Swallow the medicine without crushing or chewing it.

This medicine may be taken with or without food.

It is very important that you take the medicine at about the same time every day. It will work best if you do this.

Keep the medicine at room temperature. Avoid heat and direct light.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you forget to take a dose on time, take it as soon as you remember. If it is almost time for the next dose, do not take the missed dose. Return to your normal dosing schedule. Do not take 2 doses of this medicine at one time.

Please tell your doctor and pharmacist about all the medicines you take. Include both prescription and over-the-counter medicines. Also tell them about any vitamins, herbal medicines, or anything else you take for your health.

This medicine may cause low blood sugar. It is very important to have regular meals and exercise regularly as instructed by your doctor. Notify your doctor if you experience symptoms of low blood sugar.

If you have diabetes, this medicine may hide some signs of low blood sugar, such as fast heartbeat. Check your blood sugar regularly and for other signs of low blood sugar.

Symptoms of low blood sugar may include nausea, shaking, sweating, cold skin, fast heartbeat, hunger, and irritability.

Do not suddenly stop taking this medicine. Check with your doctor before stopping.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine. Symptoms of an allergic reaction can include trouble breathing, skin rash, itching, swelling, or severe dizziness.

Some patients with weak hearts may have worsening of symptoms. If you notice difficulty breathing, weight gain, or swelling of your legs or ankles, let your doctor know right away.

Do not use the medication any more than instructed.

This medicine may cause dizziness or fainting, especially after exercising or in hot weather. Be very careful when standing or sitting up quickly.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

Please check with your doctor before drinking alcohol while on this medicine.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

Ask your pharmacist if this medicine can interact with any of your other medicines. Be sure to tell them about all the medicines you take.

Please tell all your doctors and dentists that you are on this medicine before they provide care.

Do not start or stop any other medicines without first speaking to your doctor or pharmacist.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• diarrhea
• dizziness
• drowsiness or sedation
• lack of energy and tiredness
• slow heartbeat
• low blood pressure

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• confusion
• depression or feeling sad
• fainting
• pale or blue skin, lips or fingernails
• shortness of breath
• unusual or unexplained tiredness or weakness
• sudden or unexplained weight gain

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Extra

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.

https://krames.meducation.com/V2.0/fdbpem/7168

IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all
there is to know about it.Your doctor or pharmacist may give you other documents about your medicine.
Please talk to them if you have any questions.Always follow their advice. There is a more complete
description of this medicine available in English.Scan this code on your smartphone or tablet or use
the web address below. You can also ask your pharmacist for a printout. If you have
any questions, please ask your pharmacist.

© 2021 First Databank, Inc.

Arpimed

Metoprolol, 50 mg tablets

Release form Tablets

ATC category Cardiology. Angiology

ATC subcategory Adrenoblockers

Trade name Metoprolol

International name of the drug Metoprolol tartrate (Metoprolol tartrate)

Dosage form

Oral tablets

General characteristics

Basic physical and chemical properties

White, round, biconvex tablets scored on one side; without smell.

Composition

One tablet contains:

active substances: metoprolol tartrate – 50 mg

excipients: 9002 3 microcrystalline cellulose, lactose monohydrate, povidone, sodium starch glycolate, magnesium stearate, calcium hydrogen phosphate.

Pharmacological group and ATC code

Cardioselective beta ₁ – adrenoblocker. C07AB02

Pharmacological action

Metoprolol selectively blocks beta1-adrenergic receptors located in the heart muscle. Reduces the formation of cAMP from ATP stimulated by catecholamines, inhibiting the activity of the renin-angiotensin system. It exhibits a membrane-stabilizing effect, has a negative chrono-, dromo-, batmo- and inotropic effect, removing excessive impulses during arrhythmias, extrasystole, tachycardia. It slows down the sinus rhythm and suppresses the increased stimulation of the heart muscle in the atrioventricular node, thereby reducing conduction. As a result, the heart rate slows down, blood pressure decreases, and myocardial oxygen demand decreases. Possesses weakly expressed internal sympathomimetic activity.

Pharmacokinetics

Absorption: After oral administration, metoprolol is almost completely (approximately 95%) absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is reached after 1.5-2 hours. Bioavailability increases with food intake.

Metabolism: Plasma protein binding – 12%. In the liver, metoprolol is intensively biotransformed, undergoing stereoselective metabolism with the formation of inactive metabolites. The half-life with active metabolism lasts 3-4 hours, and with passive metabolism 7-8 hours. Penetrates through the blood-brain and placental barrier. It is excreted in breast milk in small amounts.

Excretion: The plasma half-life is about 3.5 hours. Excreted mainly by the kidneys in the form of inactive metabolites (95%), about 3% – unchanged.

Indications

• moderate to moderate arterial hypertension (as monotherapy or in combination with other antihypertensive drugs)
• cardiac arrhythmia (sinus tachycardia, ventricular and supraventricular arrhythmia, extrasystole)
• early use of metoprolol in acute myocardial infarction, reduces the size of the infarct zone and the frequency of ventricular fibrillation. Pain relief may reduce the need for opioid analgesics.
• angina pectoris
• secondary prevention of myocardial infarction
• thyrotoxicosis (in complex therapy)
• prophylaxis of migraine attacks

Dosage and administration

Inside, with a meal or immediately after a meal, the tablets can be divided in half, but not chewed and washed down with liquid.

The recommended maximum dose should not exceed 400 mg/day.

In arterial hypertension initial dose – 100 mg/day in 1-2 doses, if necessary – 200 mg/day. Combination therapy with diuretics and vasodilators may also be considered to further lower blood pressure.

For angina pectoris – 50 – 100 mg 2-3 times a day.

For tachyarrhythmia – 50 mg 2-3 times a day, if necessary – 200-300 mg / day.

Early prevention of myocardial infarction – 200 mg/day.

Orally, therapy should begin within 15 minutes of the last intravenous injection, 50 mg every 6 hours for 48 hours and preferably within 12 hours of onset of chest pain. Patients who cannot tolerate the full intravenous dose should receive half the recommended oral dose.

Maintenance dose

The usual maintenance dose is 200 mg divided into several doses. Treatment should continue for at least 3 months.

Thyrotoxicosis

50 mg 4 times a day. After normalization of thyroid function, the dose should be gradually reduced.

Migraine prophylaxis – 100-200 mg/day in 2-4 divided doses.

For relief of paroxysmal supraventricular tachycardia is administered parenterally, in a hospital, slowly, at a dose of 2-5 mg (1-2 mg/min). After arresting an attack of arrhythmia, patients are transferred to oral administration at a dose of 50 mg 4 times a day, with the first dose being taken 15 minutes after the cessation of intravenous administration.

Pediatric

Not recommended.

Patients with renal or hepatic insufficiency

Dose adjustment required. You need to follow the doctor’s advice.

Contraindications

• if you are allergic (hypersensitive) to metoprolol or any of the other ingredients of this medicine
• atrioventricular block 2-3 degree
• uncontrolled heart failure
• severe sinus bradycardia (< 45-50 bpm)
• sick sinus syndrome (in case no pacemaker is installed)
• Prinzmetal’s angina pectoris
• myocardial infarction complicated by severe bradycardia, first-degree conduction block, systolic hypotension (less than 100 mmHg) and/or severe heart failure and cardiogenic shock – severe peripheral circulatory disorders
• bronchial asthma or history of bronchospasm
• pheochromocytoma
• metabolic acidosis
• concomitant intravenous use of calcium blockers such as verapamil or diltiazem or other antiarrhythmic drugs (such as disopyramide) is contraindicated (exception: use in the intensive care unit) – arterial hypotension
• diabetes mellitus with frequent episodes of hypoglycemia
• chronic obstructive pulmonary disease.

Adverse reactions

Adverse reactions identified in the course of clinical trials or as a result of established use according to the indication according to the following classification:

Very often (≥1/10), often (≥1/100 to <1/ 10), rare ((≥1/1000 to <1/100), rare ((≥1/10000 <1/1000) and very rare (<1/10000).

* (relevance to the use of metoprolol has not been clearly established).

Beta-blockers may mask symptoms of thyrotoxicosis or hypoglycemia.

Reporting side effects

If you notice any side effects, tell your doctor, pharmacist or pharmacist, including any side effects not listed in this package insert. You can also report side effects to Arpimed LLC by going to the website www.arpimed.com and filling out the appropriate form “Report a side effect or ineffectiveness of a drug” and to the Scientific Center for Expertise of Drugs and Medical Technologies named after. Academician E.Gabrielyan by going to the website www.pharm.am in the section “Report a side effect of a drug” and fill out the form “Map of reports on a side effect of a drug”. Scientific center hotline: +37410200505; +37496220505 By reporting side effects, you help gather more information about the safety of this drug.

Overdose

Symptoms : severe arterial hypotension, sinus bradycardia, atrioventricular block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, impaired consciousness, coma, nausea, vomiting, cyanosis, hypoglycemia, and occasionally hyperkalemia. The first manifestations usually appear within 20 minutes – two hours after taking the drug.

Treatment: symptomatic therapy, absorption of any drug still present in the gastrointestinal tract can be prevented by induction of vomiting, gastric lavage, administration of activated charcoal and laxative. Artificial respiration may be required. In case of bradycardia and myocardial conduction disturbances, intensive therapy is indicated: intravenous bolus (with a 25-minute interval) administration of atropine sulfate at a dose of 0.5-2 mg. With a decrease in myocardial contractility, intravenous administration of glucagon is indicated at an initial dose of 1-10 mg, then at a dose of 2-2.5 mg/h as a long-term drip infusion. If a convulsive syndrome occurs, a slow intravenous administration of diazepam is recommended. After taking a large dose or in case of hypersensitivity, the patient should be closely monitored and treated in an intensive care unit.

Hypotension and shock should be treated with plasma/plasma substitutes and, if necessary, catecholamines. The beta-blocking effect can be neutralized by slow intravenous administration of isoprenaline hydrochloride, starting at a dose of about 5 mcg / min, or dobutamine, starting at a dose of 2.5 mcg / min, until the desired effect is achieved.

In resistant cases, isoprenaline can be combined with dopamine. If the desired result is not achieved after this, the possibility of taking 8-10 mg of glucagon can be considered. If necessary, the injection can be repeated within 1 hour, after which, if necessary, make an intravenous infusion of glucagon at a rate of 1-3 mg/hour.

Calcium ions or a pacemaker may be considered.

In patients who have received an overdose of hydrophilic beta-blocking drugs, hemodialysis or hemoperfusion may be considered.

Special instructions

Abrupt discontinuation of therapy with beta-blockers should be avoided, especially in patients with ischemic heart disease. If possible, metoprolol should be discontinued gradually over 10 days, reducing the dose to 25 mg over the last 6 days. If necessary, you can start replacement therapy at the same time to prevent exacerbation of angina pectoris. In addition, hypertension and arrhythmia may develop.

In combination therapy with clonidine, the latter should be discontinued a few days after the withdrawal of metoprolol, in order to avoid a hypertensive crisis. At a dose above 200 mg / day, cardioselectivity decreases.

If a decision has been made to interrupt beta-blockade in preparation for surgery, therapy should be discontinued for at least 24 hours. Continued beta blockade reduces the risk of arrhythmia during induction and intubation, but the risk of hypertension may also increase. If treatment is continued, caution should be exercised when using certain anesthetics. The patient can be protected from vagal reactions by intravenous atropine. During its cancellation, the patient’s condition should be carefully monitored.

Although cardioselective beta-blockers may have less effect on lung function than nonselective beta-blockers, their use should be avoided in patients with reversible obstructive airway disease unless there are compelling clinical reasons for their use. Although metoprolol has been shown to be safe in a large number of asthma patients, caution is advised when treating patients with chronic obstructive pulmonary disease. Beta-2 stimulant therapy or adjustment of current therapy may be required. Thus, non-selective beta-blockers should not be used in such patients, and beta-1-selective blockers should only be used with extreme caution. It is recommended to stop therapy with the appearance of skin rashes and the development of depression caused by taking beta-blockers.

Discontinuation of the drug should be considered if any similar reaction cannot be explained by anything other than the drug. Cancellation of beta-blockers should be gradual.

Metoprolol should not be administered to patients with untreated congestive heart failure. The first step is to get congestive heart failure under control. If concomitant treatment with digoxin is carried out, it must be borne in mind that both drugs slow down AV conduction and, therefore, there is a risk of AV dissociation. In addition, mild cardiovascular complications may occur, manifesting as dizziness, bradycardia, and a tendency to collapse.

Serious, sometimes even life-threatening, deterioration in cardiac function may occur with the use of beta-blockers, especially in patients whose cardiac function depends on the supportive action of the sympathetic system. This is not so much due to an excessive beta-blocking effect, but to the fact that patients with limited heart function do not tolerate a decrease in sympathetic nervous system activity, even if this decrease is small. This leads to a weakening of contractility, a decrease in heart rate and a slowdown in AV conduction. This may result in pulmonary edema, atrioventricular block, and shock. Sometimes an existing AV conduction disorder may worsen, leading to AV block. Patients with pheochromocytoma should be given concomitant alpha-blockers.

If surgery is required, the anesthesiologist should be warned about the ongoing therapy (selection of a drug for general anesthesia with a minimal negative inotropic effect), discontinuation of the drug is not recommended.

Initial administration of high doses of metoprolol to patients undergoing extracardiac surgery should be avoided as it is associated with bradycardia, hypotension and stroke, including death in patients who have risk factors for the cardiovascular system.

Beta-blockers mask some of the clinical signs of thyrotoxicosis. Therefore, metoprolol should be used with caution in patients with or suspected of developing thyrotoxicosis, and thyroid and cardiac function should be closely monitored.

Concomitant use of epinephrine (epinephrine), norepinephrine (norepinephrine) and β-blockers may lead to increased blood pressure and bradycardia.

Metoprolol may cause or exacerbate bradycardia, peripheral arterial circulation symptoms and anaphylactic shock. If the pulse rate drops below 50-55 beats per minute at rest and the patient develops symptoms associated with bradycardia, the dose should be reduced.

Metoprolol can be used in controlled heart failure. In patients with a history of heart failure or low cardiac reserve, treatment with cardiac glycosides and/or diuretics should also be considered.

Metoprolol may reduce the effectiveness of diabetes treatment and mask the symptoms of hypoglycemia. The risk of impaired carbohydrate metabolism or masking symptoms of hypoglycemia is lower with extended release metoprolol tablets than with conventional beta-1 selective blocker tablets and significantly lower than with non-selective beta-blockers. In unstable and insulin-dependent diabetes mellitus, adjustment of hypoglycemic therapy may be required.

In the case of unstable or insulin-dependent diabetes mellitus, adjustment of hypoglycemic treatment may be required (because of the likelihood of severe hypoglycemic conditions).

In patients with significant hepatic impairment, dosage adjustment may be required because metoprolol is biotransformed in the liver. Patients with hepatic or renal insufficiency may require a lower dosage, metoprolol is contraindicated in patients with hepatic or renal disease / insufficiency. Older people should be given with caution, starting with a lower dose, although the elderly usually tolerate this drug well. In elderly patients and patients with hepatic or renal insufficiency, it may be necessary to use the drug at a lower dose, as well as the need to prescribe an alternative drug.

Patients with a history of psoriasis should only take beta-blockers after careful consideration as the drug may exacerbate psoriasis.

Beta-blockers can increase both sensitivity to allergens and the severity of anaphylactic reactions. Treatment with epinephrine (epinephrine) does not always provide the desired therapeutic effect in individuals receiving beta-blockers.

Beta-blockers may unmask myasthenia gravis.

In cirrhosis of the liver, the bioavailability of metoprolol may be increased and the dosage should be adjusted accordingly.

1 tablet of the drug contains 16 mg of lactose monohydrate, so if you have intolerance to some sugars, contact your doctor before taking this drug.

Patients using contact lenses should take into account that during treatment with beta-blockers, a decrease in the production of lacrimal fluid is possible. Dry eyes may occur, sometimes accompanied by skin rashes. In most cases, the symptoms disappeared after discontinuation of treatment with metoprolol. Patients should be closely monitored for adverse eye reactions. If such reactions occur, the possibility of discontinuing metoprolol should be considered.

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Pregnancy and lactation

Pregnancy

Metoprolol is not recommended during pregnancy or lactation unless the expected benefit outweighs the possible risk to the fetus/infant.

Metoprolol, however, has been used for pregnancy-associated hypertension under close supervision after the 20th week of pregnancy. Although the drug crosses the placental barrier and is found in cord blood, there are no reported cases of fetal anomalies. Despite this, there is an increased risk of cardiac and pulmonary complications in the newborn in the postpartum period. Beta-blockers reduce placental perfusion and can cause fetal death and preterm birth.

Fetal growth retardation has been observed after long-term treatment in pregnant women with mild to moderate hypertension. Beta-blockers have been reported to cause fetal and neonatal bradycardia, and there have been reports of hypoglycemia and hypotension in neonates.

Interrupt treatment with metoprolol 48-72 hours before delivery. If this is not possible, close medical monitoring of the newborn is required 24 to 48 hours after birth for symptoms of beta-blockade (eg, cardiac and pulmonary complications). Careful medical supervision of newborns in the first 3-5 days of life is required. The drug passes into breast milk. If necessary, the use of the drug during lactation should stop breastfeeding.

Breast-feeding

Metoprolol is excreted in milk. Despite the fact that the concentration of metoprolol in milk is very low, it is necessary to stop breastfeeding during treatment with metoprolol.

If you are pregnant or breastfeeding, think you are pregnant or plan to become pregnant, ask your doctor or pharmacist for advice before using this medicine.

Drug interactions

• drugs used to treat stomach ulcers such as cimetidine – drugs used to treat high blood pressure such as hydralazine, clonidine or prazosin
• drugs used to treat irregular heart rhythms such as amiodarone and propafenone
• medicines used to treat depression such as tricyclic antidepressants or SSRIs
• drugs used to treat epilepsy, such as barbiturates
• medicines for the treatment of mental illness, such as phenothiazines
• anesthetics such as cyclopropane or trichloroethylene
• medicines used to treat certain types of cancer, particularly kidney cancer, such as aldesleukin
• medicines used to treat erectile dysfunction, such as alprostadil
• anxiolytics or hypnotics (eg temazepam, nitrazepam, diazepam),
• indomethacin or celecoxib (NSAID)
• rifampicin (antibiotic) or terbinafine (antifungal)
• estrogens, such as contraceptives or hormone replacement therapy
• corticosteroids (eg hydrocortisone, prednisolone)
• other beta-blockers, eg eye drops
• epinephrine (epinephrine) or norepinephrine (norepinephrine), used in anaphylactic shock or other sympathomimetics, drugs used to treat diabetes mellitus
• lidocaine (local anesthetic)
• moxisilite (used for Raynaud’s syndrome)
• drugs used in the treatment of malaria, such as mefloquine
• medicines used to prevent nausea and vomiting, such as tropisetron – medicines used to treat bronchial asthma, such as xanthines, such as aminophylline or theophylline
• drugs used to treat migraine, such as ergotamine
• drugs used to treat heart problems, such as cardiac glycosides, such as digoxin
• medicines used to treat rheumatoid arthritis, such as hydroxychloroquine
• diphenhydramine (sedative, antihistamine).