5mg Lexapro Side Effects: Comprehensive Guide to Escitalopram’s Impact
What are the common side effects of 5mg Lexapro. How can patients manage nausea and headaches while taking escitalopram. When should you seek medical attention for Lexapro side effects. How does escitalopram affect sexual function.
Understanding Escitalopram: An Overview of 5mg Lexapro
Escitalopram, commonly known by its brand name Lexapro, is a widely prescribed antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) class. While it effectively treats depression and anxiety disorders, it’s crucial to understand its potential side effects, particularly at the 5mg dosage.
Escitalopram works by increasing serotonin levels in the brain, which can lead to improved mood and reduced anxiety. However, this mechanism of action can also result in various side effects as the body adjusts to the medication.
Common Side Effects of 5mg Lexapro: What to Expect
When starting escitalopram at 5mg, patients may experience several common side effects. These typically affect more than 1 in 100 people and often improve as the body adjusts to the medication:
- Nausea
- Headaches
- Dry mouth
- Excessive sweating
- Insomnia
- Drowsiness
- Fatigue or weakness
Is it normal to experience these side effects when starting Lexapro? Yes, these reactions are typical and often subside within the first few weeks of treatment. However, if they persist or become bothersome, it’s important to consult with a healthcare provider.
Managing Nausea and Gastrointestinal Issues
Nausea is one of the most commonly reported side effects of escitalopram. To alleviate this symptom:
- Take the medication with or after food
- Avoid rich or spicy foods
- Eat smaller, more frequent meals
- Stay hydrated
Can ginger or peppermint help with Lexapro-induced nausea? Some patients find relief with natural remedies like ginger tea or peppermint candies, but it’s essential to consult with a doctor before combining any supplements with escitalopram.
Coping with Headaches and Fatigue
Headaches and fatigue are common initial side effects of 5mg Lexapro. To manage these symptoms:
- Ensure adequate rest and hydration
- Limit alcohol consumption
- Use over-the-counter pain relievers as recommended by a pharmacist
- Practice stress-reduction techniques like meditation or yoga
How long do Lexapro-induced headaches typically last? Most patients find that headaches subside within the first week of treatment. If they persist beyond this period or become severe, it’s crucial to consult a healthcare provider.
Sleep Disturbances: Insomnia and Drowsiness
Escitalopram can affect sleep patterns, causing either insomnia or excessive drowsiness. To address these issues:
For Insomnia:
- Take escitalopram in the morning
- Establish a consistent sleep schedule
- Practice good sleep hygiene
- Avoid caffeine and electronic devices before bedtime
For Drowsiness:
- Take escitalopram in the evening
- Avoid driving or operating machinery if feeling sleepy
- Limit alcohol consumption
Does the timing of Lexapro intake affect sleep quality? Yes, the timing of medication can significantly impact sleep patterns. Patients experiencing sleep disturbances should discuss adjusting their dosage schedule with their healthcare provider.
Sexual Side Effects of Escitalopram
Sexual dysfunction is a potential side effect of escitalopram that can be particularly distressing for some patients. These effects may include:
- Decreased libido
- Difficulty achieving orgasm
- Erectile dysfunction in men
- Vaginal dryness in women
Are sexual side effects of Lexapro permanent? In most cases, sexual side effects are temporary and improve over time. However, if they persist, patients should discuss alternative treatments or dosage adjustments with their healthcare provider.
Recognizing Serious Side Effects: When to Seek Medical Attention
While most side effects of 5mg Lexapro are mild, some can be serious and require immediate medical attention. Patients should contact their doctor or seek emergency care if they experience:
- Unexplained weight changes
- Menstrual irregularities
- Persistent headaches or confusion
- Muscle cramps
- Signs of low sodium levels (confusion, weakness)
- Symptoms of serotonin syndrome (high fever, agitation, tremors)
- Unusual bleeding or bruising
What are the signs of an allergic reaction to Lexapro? Severe allergic reactions, though rare, can occur. Symptoms include sudden swelling of the lips, mouth, or throat, difficulty breathing, and skin rashes. These require immediate emergency medical attention.
Long-Term Side Effects and Monitoring
While escitalopram is generally considered safe for long-term use, patients should be aware of potential long-term effects and the importance of regular monitoring:
- Bone density changes
- Increased risk of gastrointestinal bleeding
- Potential impact on cognitive function in older adults
How often should patients on long-term Lexapro treatment be monitored? Regular check-ups, typically every 3-6 months, are recommended to assess the medication’s effectiveness and monitor for any developing side effects.
Strategies for Minimizing Side Effects
While side effects can be challenging, there are several strategies patients can employ to minimize their impact:
- Start with a low dose and gradually increase as directed by a healthcare provider
- Take the medication consistently at the same time each day
- Maintain open communication with healthcare providers about any side effects
- Consider lifestyle changes to support overall well-being, such as regular exercise and a balanced diet
- Avoid alcohol and other substances that may interact with escitalopram
Can complementary therapies help manage Lexapro side effects? Some patients find relief through complementary approaches like acupuncture or mindfulness practices. However, it’s essential to discuss any additional treatments with a healthcare provider to ensure safety and effectiveness.
Comparing 5mg Lexapro to Other Dosages
The 5mg dose of Lexapro is often used as a starting dose or for maintenance therapy. Understanding how it compares to other dosages can help patients and healthcare providers make informed decisions:
- 5mg: Often used as an initial dose or for elderly patients
- 10mg: Standard therapeutic dose for most adults
- 20mg: Maximum recommended dose for depression
Are side effects more likely at higher doses of Lexapro? Generally, higher doses may increase the likelihood or severity of side effects. However, individual responses vary, and some patients may tolerate higher doses without additional side effects.
Discontinuation and Withdrawal: Managing the Transition
When discontinuing escitalopram, even at the 5mg dose, patients may experience withdrawal symptoms. These can include:
- Dizziness
- Nausea
- Flu-like symptoms
- Irritability
- Sensory disturbances (e.g., electric shock sensations)
How should patients safely discontinue Lexapro? Discontinuation should always be done under medical supervision. Typically, a gradual tapering of the dose is recommended to minimize withdrawal symptoms.
Drug Interactions and Precautions
Escitalopram can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. Key interactions to be aware of include:
- Other antidepressants, particularly MAOIs
- NSAIDs and blood thinners
- Certain migraine medications
- St. John’s Wort and other herbal supplements
What should patients disclose to their healthcare provider before starting Lexapro? It’s crucial to provide a complete medical history, including all current medications, supplements, and health conditions, to ensure safe and effective treatment.
Special Populations: Considerations for Specific Groups
The effects and side effects of escitalopram can vary among different populations:
Elderly Patients:
- May be more sensitive to side effects
- Often start at lower doses (e.g., 5mg)
- Require closer monitoring for hyponatremia
Pregnant and Breastfeeding Women:
- Potential risks to fetal development
- May pass into breast milk
- Require careful risk-benefit assessment
Children and Adolescents:
- Increased risk of suicidal thoughts
- Require close monitoring for behavioral changes
- May have different side effect profiles compared to adults
How does Lexapro affect adolescent brain development? Research in this area is ongoing, but current evidence suggests that SSRIs like escitalopram may influence brain plasticity and neurodevelopment in adolescents. Long-term studies are needed to fully understand these effects.
Alternative Treatments and Adjunct Therapies
For patients experiencing significant side effects from 5mg Lexapro, alternative treatments or adjunct therapies may be considered:
- Other antidepressants (e.g., SNRIs, NDRIs)
- Psychotherapy (e.g., cognitive-behavioral therapy)
- Lifestyle modifications (e.g., exercise, diet changes)
- Complementary therapies (e.g., mindfulness meditation)
Can combining Lexapro with other treatments reduce side effects? In some cases, combining escitalopram with other therapies may allow for lower doses, potentially reducing side effects while maintaining efficacy. However, this approach should only be undertaken under close medical supervision.
The Future of Escitalopram: Emerging Research and Developments
Ongoing research continues to shed light on escitalopram’s mechanisms of action, potential new applications, and strategies for minimizing side effects:
- Genetic factors influencing response and side effects
- Novel drug delivery methods to reduce systemic side effects
- Combination therapies for treatment-resistant depression
- Long-term effects on brain structure and function
What advancements in SSRI technology might reduce side effects in the future? Researchers are exploring targeted drug delivery systems and personalized medicine approaches that could potentially reduce systemic exposure and tailor treatments to individual patient profiles, potentially minimizing side effects.
Understanding the side effects of 5mg Lexapro is crucial for patients and healthcare providers alike. While many side effects are mild and transient, being informed about potential risks and management strategies can significantly improve the treatment experience. As with any medication, the benefits of escitalopram should be weighed against its potential side effects, and treatment decisions should be made in consultation with a qualified healthcare professional. By staying informed and maintaining open communication with healthcare providers, patients can maximize the benefits of escitalopram while minimizing its impact on their daily lives.
Side effects of escitalopram – NHS
Like all medicines, escitalopram can cause side effects in some people, but many people have no side effects or only minor ones.
Some of the common side effects of escitalopram will gradually improve as your body gets used to it.
Common side effects
Common side effects of escitalopram happen in more than 1 in 100 people. There are things you can do to help cope with them:
Feeling sick (nausea)
Try taking escitalopram with or after food. It may also help if you avoid rich or spicy food.
Headaches
Make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller.
Headaches should usually go away after the first week of taking escitalopram.
Talk to your doctor if they last longer than a week or are severe.
A dry mouth
Chew sugar-free gum or suck sugar-free sweets.
Sweating a lot
Try wearing loose clothing and using a strong anti-perspirant. If this does not control the problem, talk to your doctor. You may need to try a different antidepressant.
Being unable to sleep
Take escitalopram first thing in the morning.
Feeling sleepy
Take escitalopram in the evening and cut down the amount of alcohol you drink. Do not drive, ride a bike or use tools or machinery if you’re feeling sleepy. If this does not help, talk to your doctor.
Feeling tired or weak
Stop what you’re doing and sit or lie down until you feel better. Do not drive, ride a bike or use tools or machinery if you’re feeling tired. Do not drink alcohol as it will make you feel worse.
Speak to a doctor or pharmacist if the advice on how to cope does not help and any of these side effects bother you or last more than a few days.
Serious side effects
Book an appointment with your doctor if:
- you lose or gain weight without trying
- you get changes in your periods, such as heavy bleeding, spotting or bleeding between periods
Call your doctor or call 111 now if:
- you have constant headaches, long-lasting confusion or weakness, or frequent muscle cramps – these can all be signs of low sodium levels in your blood
- you have a high temperature, feel agitated or confused, or you’re trembling and twitching – this could be a sign of serotonin syndrome
- you start coughing up blood or have blood in your pee
- you have black or red poo or blood in your vomit – these can be signs of bleeding from the gut
- you are bleeding from the gums, or have bruises that appear without a reason or get bigger
Immediate action required: Call 999 or go to A&E now if:
- you get painful erections that last longer than 2 hours – this may happen even when you’re not having sex
- you have severe dizziness or pass out
- you get any bleeding that’s severe or you cannot stop, such as cuts or nosebleeds that do not stop within 10 minutes
- you have thoughts about harming yourself or ending your life
Find your nearest A&E
Serious allergic reaction
In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to escitalopram.
Immediate action required: Call 999 now if:
- your lips, mouth, throat or tongue suddenly become swollen
- you’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- your throat feels tight or you’re struggling to swallow
- your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- you suddenly become very confused, drowsy or dizzy
- someone faints and cannot be woken up
- a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)
You or the person who’s unwell may also have a rash that’s swollen, raised, itchy, blistered or peeling.
These can be signs of a serious allergic reaction and may need immediate treatment in hospital.
Sexual side effects
The good effects of escitalopram may, after a while, improve your sex life as your mood lifts and you become interested in life and relationships again.
Some of the possible sexual side effects include:
- painful erections and problems getting an erection and ejaculating
- vaginal bleeding and not reaching orgasm the same way as before
- a lower sex drive
Sexual side effects usually pass after the first couple of weeks. However, very rarely, they can be long lasting and may not get better even after stopping the medicine.
If these happen and are a problem for you, go back to your doctor to see if there’s another treatment you can try.
Other side effects
These are not all the side effects of escitalopram. For a full list, see the leaflet inside your medicine packet.
Information:
You can report any suspected side effect using the Yellow Card safety scheme.
Visit Yellow Card for further information.
Page last reviewed: 24 February 2022
Next review due: 24 February 2025
What are the side effects of Lexapro?
Doctors prescribe Lexapro for anxiety and depression. It can cause nausea, dizziness, and other side effects in adults. Lexapro can also potentially cause severe side effects, such as suicidal thoughts, and make depression worse.
If you have depression or generalized anxiety disorder, your doctor may want to give you Lexapro. This drug can be very effective in treating either condition. But like all drugs, it may cause side effects.
Some of these may only be bothersome, while others may be severe and impact your health.
Learning about the side effects can help you decide if the drug is right for you. Here’s an overview of the side effects Lexapro can cause.
Lexapro is a prescription drug. It’s available as an oral tablet and an oral liquid solution. It’s approved for use in adults and children 12 years and older.
The medication belongs to the class of drugs called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of the chemical serotonin in your brain. Having more serotonin helps decrease the symptoms of depression and anxiety. Lexapro is not considered a monoamine oxidase inhibitor (MAOI). MAOIs work by slowing down the breakdown of serotonin and dopamine, another chemical in your brain. This also helps alleviate symptoms of depression. However, MAOIs have a higher risk of side effects and drug interactions than SSRIs such as Lexapro.
SSRIs, including Lexapro, are tolerated well compared to other types of antidepressants.
In general, you may have more side effects if you take a higher dosage of the drug. At a high dosage, Lexapro is more likely to cause gastrointestinal side effects, such as diarrhea.
Common side effects
The side effects of Lexapro seem to be the same in both men and women. The side effects are slightly different for adults and children.
Adult side effects can include:
- nausea
- sleepiness
- weakness
- dizziness
- anxiety
- sleeping trouble
- sexual problems, such as decreased sex drive and erectile dysfunction
- sweating
- shaking
- loss of appetitive
- dry mouth
- constipation
- infection
- yawning
The side effects for children and adolescents can include the above, plus:
- increased thirst
- abnormal increase in muscle movement or agitation
- nosebleeds
- trouble urinating
- heavy menstrual periods
- slowed growth and weight change
There have been some cases of decreased appetite and weight loss with the use of Lexapro in children and adolescents.
Your child’s doctor may check their height and weight during treatment.
People with depression tend to have a low appetite and reduced body weight. In adults, some sources say Lexapro may cause a small amount of weight gain. However, if you gain weight, your weight may just be evening out because your depression is better managed and your appetite has returned. Other people lose weight when they’re taking Lexapro. The increase in serotonin may lead to loss of appetite.
Most of these side effects are mild. They should eventually go away on their own without treatment. If they’re more severe or don’t go away, tell your doctor.
Boxed warning side effects
A boxed warning is the most serious warning from the U.S. Food and Drug Administration (FDA).
Lexapro may increase suicidal thoughts or actions. This risk is higher in in children, teenagers, or young adults. This is more likely to happen within the first few months of treatment or during dosage changes.
Call your doctor right away if you have any of the following symptoms, or call 911 or local emergency services if the symptoms are new, worse, or worrisome:
- attempts to commit suicide
- acting on dangerous impulses
- aggressive or violent actions
- thoughts about suicide or dying
- new or worse depression
- new or worse anxiety or panic attacks
- feeling restless, angry, or irritable
- trouble sleeping
- increased activity (doing more than what is normal for you)
- other unusual changes in your behavior or mood
Other serious side effects
Lexapro can also cause other serious side effects. Call your doctor right away if you have serious side effects. Call 911 or local emergency services if your symptoms feel life-threatening or if you think you’re having a medical emergency.
Severe allergic reactions
You should not take Lexapro if you’re allergic to it, its ingredients, or the antidepressant Celexa.
Symptoms can include:
- breathing trouble
- swelling of your face, tongue, eyes, or mouth
- severe rash, hives (itchy welts), or blisters that may come on with fever or joint pain
Seizures or convulsions
There have been reports of some people having seizures while taking Lexapro. People with a history of seizures are at higher risk.
Serotonin syndrome
This is a serious condition. It happens when the levels of serotonin in your body get too high. It’s more likely to occur if you also take other drugs that increase serotonin, such as other antidepressants or lithium. Symptoms can include:
- agitation
- hallucinations (seeing or hearing things that aren’t real)
- coma (loss of consciousness)
- coordination problems, overactive reflexes, or muscle twitching
- racing heart rate
- high or low blood pressure
- sweating or fever
- nausea, vomiting, or diarrhea
- muscle stiffness
Low salt levels
Lexapro may cause low salt levels in your body.
This may be more likely to occur in seniors, people who take water pills, or people who are dehydrated. This side effect may cause:
- headache
- confusion
- trouble concentrating
- thinking or memory problems
- weakness
- unsteadiness that can lead to falls
- seizures
Manic episodes
If you have bipolar disorder, Lexapro may cause you to have a manic episode. Taking Lexapro without another drug for bipolar disorder may trigger an episode. Symptoms can include:
- greatly increased energy
- severe sleeping trouble
- racing thoughts
- reckless behavior
- unusually grand ideas
- excessive happiness or irritability
- talking quickly or more than normal
Vision problems
Lexapro may dilate your pupils. This may trigger a glaucoma attack, even if you don’t have a history of eye problems. Symptoms can include:
- eye pain
- changes in your vision
- swelling or redness in or around your eye
Side effects with other health conditions
If you have certain health conditions, you likely should not take Lexapro.
In some cases, your doctor may lower your dosage or watch you more closely during your treatment with it. Tell your doctor if you have any of the following health conditions before taking Lexapro.
- A history of suicidal thoughts or behaviors—Lexapro can increase the risk of suicidal thinking and behavior, especially in children, teens, and young adults.
- Bipolar disorder—if you take Lexapro without taking other medications for bipolar disorder, Lexapro may bring on a manic episode.
- Seizures—this drug may cause seizures and make your seizure disorder worse.
- Glaucoma—this drug may bring on a glaucoma attack.
- Low salt levels—Lexapro can further lower your salt levels.
- Pregnancy—it isn’t known if Lexapro will harm your unborn baby.
- Breastfeeding—Lexapro may pass into breast milk and cause side effects in a child who is breastfed.
Certain medications can interact with Lexapro. Be sure to tell your doctor about all over-the-counter and prescription drugs, supplements, and herbs you take.
Lexapro may interact with the following drugs:
- blood thinners such as warfarin to increase your risk of bleeding
- nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin to increase your risk of bleeding
- other drugs used to treat depression to increase the level of serotonin in your body, which can cause serotonin syndrome
Lexapro is a powerful drug used to treat depression and anxiety. While it can be very effective, it may also cause side effects. Be sure to tell your doctor about other health conditions you have and medications you take before starting Lexapro. This information can help your doctor reduce your chance of side effects. Also tell your doctor if you do have any side effects. If you can’t tolerate the effects, your doctor may change your medication. Keep in mind that Lexapro and other drugs in its class cause many of the same side effects.
Lexapro: common and serious side effects
Disclaimer
If you have any medical questions or concerns, contact your doctor.
Articles in the Health Guide are based on peer-reviewed research and information from medical societies and government agencies. However, they are not a substitute for professional medical advice, diagnosis or treatment.
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Side effects of Lexapro
Passing a day when you are depressed is already a lot to achieve. Depression doesn’t just affect the mind; it also affects the body. Depression and chronic pain are closely linked (Lee, 2018). So it’s only natural if you want to know if your antidepressant is causing side effects, what they are, and how likely you are to experience them when you’re already dealing with depression.
Vitals
- Lexapro is the brand name for the drug escitalopram. It is FDA approved for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD).
- Generic Lexapro has the same active ingredient as the brand-name version.
- Common side effects of Lexapro include fatigue, nausea, sleep problems, and sexual dysfunction.
- Lexapro may cause more serious side effects such as serotonin syndrome and worsening depression in children and adolescents.
What is Lexapro?
Lexapro is a prescription drug from a group of drugs called selective serotonin reuptake inhibitors, or SSRIs. SSRIs are used to treat depression, anxiety, and other mood disorders. Researchers believe that depression is caused by an imbalance of chemicals in our brain, and globally by SSRIs. considered first line treatment (Bauer, 2009).
Lexapro is specifically approved for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD), but it may be used off-label by healthcare professionals to treat obsessive-compulsive disorder (OCD) (Zutshi, 2007).
Lexapro is the brand name for escitalopram oxalate. Although escitalopram can be confused with alprazolam, a common anxiety medication sold under the brand name Xanax, these medications are not the same.
Previously, Lexapro could only be manufactured by Forest Laboratories Inc. (in partnership with pharmaceutical company Lundbeck).
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Lundbeck has made Lexapro available as a tablet or oral solution. Tablets come in three dosages: 5 mg, 10 mg and 20 mg. The oral solution is only available in one strength equivalent to 5 mg (FDA, n.d.). Lexapro was launched in 2002, but its patent expired in March 2012, which meant that other companies could seek approval from the U.S. Food and Drug Administration (FDA) to manufacture and market escitalopram (Llamas, 2013) .
What are SSRIs and how do they work?
Depression can be treated in many ways, and there are several types of antidepressants.
Medications used to treat this mood disorder include (FDA, 2009):
- Selective serotonin reuptake inhibitors (SSRIs)
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants
- Atypical antidepressants pressants
- Selective serotonin and norepinephrine reuptake inhibitors (SNRI)
There are also many different types of SSRIs, including:
- Citalopram (brand name of Celex)
- Escitalopram (brand name of Lexapro)
- Fluvoxamine (brand name Luvox, Luvox CR)
- Paroxetine (brand name Paxil, Paxil CR, Pekseva)
- Sertraline (brand name Zoloft)
- Vilazodone (brand name Viibryd)
9 0016 Fluoxetine (trade name Prozac, Sarafem, Symbiax)
In the brain, chemical messengers called neurotransmitters carry messages from brain cell to brain cell. Serotonin is one type of neurotransmitter. SSRIs work by keeping serotonin levels high between brain cells.
SSRIs are thought to treat certain mental illnesses in this way.
Possible side effects of Lexapro
Here are the most common potential side effects of Lexapro and how often they occurred in participants with MDD in clinical trials testing the drug’s efficacy and safety:
- Nausea (15%)
- Sleep problems (9%)
- Ejaculation disorder (9%)
- Diarrhea (8%)
- Drowsiness (6%)
- Dry mouth (6%)
- Increased sweating (5%)
- Dizziness (5%)
- Flu-like symptoms (5%)
- Tiredness/fatigue (5%)
- Loss of appetite (3%)
- Low sex drive (3%)
These common Lexapro side effects also appear to be dose-dependent, meaning that you are more likely to experience these side effects if you take 20mg than 10mg. Other potential side effects of Lexapro were noted, although they were not observed in more than 2% of the participants in these studies. These symptoms included weight gain, blurred vision, muscle stiffness, and joint pain (FDA, 2017).
In clinical trials, 8% of participants who received Lexapro for GAD and 6% of participants who received prescription drug for MDD discontinued the drug due to side effects. MDD treatment studies have shown that more people stopped using Lexapro when they were given 20mg rather than 10mg daily.
If you experience side effects from Lexapro, it is important to talk to your doctor before stopping your medication. If you stop taking Lexapro suddenly, you may experience withdrawal symptoms such as nightmares, irritability, headache, nausea, dizziness, or vomiting (NAMI, 2016).
Side effects of Lexapro in men and women
Unfortunately, sexual dysfunction is a common side effect of SSRI treatment. In fact, studies have shown that this specific side effect occurs in 20–70% of patients taking these medications and is a common reason patients want to stop treatment (Osis, 2010). These sexual side effects include:
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- Erectile dysfunction
- Ejaculation disorder (delayed ejaculation)
- Decreased libido
Although researchers have noted this effect with many SSRIs, paroxetine causes the highest rate of sexual dysfunction.
Patients taking SSRIs who experience changes in their sex drive or sexual satisfaction should discuss these changes with their health care providers. In some cases, bupropion, mirtazapine, vilazodone, vortioxetine, or SNRIs may be good alternative treatments (Jing, 2016).
Lexapro drug interactions
You should not take Lexapro with certain medicines, including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. John’s wort. You should also avoid prescription drugs that affect the breakdown of serotonin in the body, especially MAOIs such as rasagiline and tranylcypromine. Combining these drugs increases the risk of a serious condition called serotonin syndrome. This syndrome occurs when there is too much active serotonin in your body. It can cause mild symptoms such as tremors and diarrhea, but can also be life-threatening (Volpi-Abadie, 2013).
You should also be careful when taking Lexapro with any blood-thinning medications, from real prescription blood thinners like warfarin to over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen and naproxen.
Lexapro may increase your risk of bleeding if you take these medicines.
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Lexapro Warnings
It may take some time to experience the full effects of Lexapro and understand the extent to which you experience side effects. Lexapro may cause drowsiness and may affect your ability to make decisions or react to events. For this reason, it is recommended that you do not drive or operate heavy machinery until you understand how this antidepressant affects you.
For the same reason, standard medical advice is to avoid drinking alcohol while taking Lexapro. Alcohol similarly affects your ability to make decisions and react to events. Clinical trials have not shown that Lexapro aggravates these effects of alcohol, but it is possible that the combination could be dangerous in certain situations.
Patients and their families should be monitored for any changes in behavior, including worsening depression, panic attacks, and suicidal ideation, when Lexapro is started or after a dose change.
Children, teenagers, and young adults are at increased risk for these side effects. In fact, the FDA has required all manufacturers of antidepressants to update their SSRI drug package information to include these risks found in short-term studies (FDA, 2018).
When to Seek Medical Care
There are serious potential side effects of antidepressants such as Lexapro. You should seek immediate medical attention if you experience increased depression, anxiety, or suicidal thoughts. Contact someone if you notice unusual changes in mood or behavior. You should also call your doctor right away if you experience (FDA, 2017):
- Any symptoms of serotonin syndrome, including coordination problems, hallucinations, palpitations, sweating, nausea, vomiting, muscle stiffness, or high or low blood pressure. pressure.
- Any symptoms of an allergic reaction, including swelling of the face, lips or tongue, difficulty breathing, rash or hives.
- Seizures
- Abnormal bleeding
- Manic episodes, which may include spasmodic thoughts, increased energy, reckless behavior, and talking more or faster than usual.
- Changes in appetite or weight, especially in children and adolescents.
- Vision problems including eye pain, swelling or redness around the eyes.
References
- Bauer, M., Bshore, T., Pfennig, A., Whybrow, P.K., Angst, J., Versiani, M.,. . . WFSBP Working Group on Unipolar Depres. (2007). World Federation of Societies for Biological Psychiatry (WFSBP) guidelines for the biological treatment of unipolar depressive disorders in primary care. World Journal of Biological Psychiatry, 8(2), 67-104. DOI: 10.1080 / 15622970701227829 Retrieved from https://www.tandfonline.com/doi/full/10.1080/15622970701227829
- Food and Drug Administration (FDA). (no data). Lexapro (escitalopram oxalate) Tablets / Oral solution label. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021323s032,021365s023lbl.pdf
- Food and Drug Administration (FDA). (2017, January). Lexapro (escitalopram oxalate). Extracted from https://www. accessdata.fda.gov/drugsatfda_docs/label/2017/021323s047lbl.pdf
- Food and Drug Administration (FDA). (2009, September). Medications to help you: depression. Retrieved from https://www.fda.gov/media/77381/download
- Food and Drug Administration (FDA). (2018, February 05). Suicidality in children and adolescents treated with antidepressants. Retrieved from https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/suicidality-children-and-adolescents-being-treated-antidepressant-medications
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accessdata.fda.gov/drugsatfda_docs/label/2017/021323s047lbl.pdf
Korean Journal of Pain, 31(2), 116-124. DOI: 10.3344/kjp.2018.31.2.116. Extracted from https://pubmed.ncbi.nlm.nih.gov/29686810/
, Mathematics, S. B., and Reddy, Y. K. (2007). Escitalopram for obsessive-compulsive disorder. Primary Health Care Assistant to the Journal of Clinical Psychiatry, 09(06), 466-467. DOI: 10.4088 / pcc.v09n0611c. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139927/Learn more
💊 Ingredients of Escitalopram ✅ Usage of Escitalopram Save Search for analogues Interaction Description of the active ingredients of the preparation Escitalopram The scientific information provided is general and cannot be used to make decisions. Update date: 2020.07.03 Marketing authorization holder: Berezovsky Pharmaceutical Plant, CJSC ATX code: N06AB10 (Escitalopram) Active substance: Rec.INN WHO registered Dosage form
Release form, packaging and composition |
10.15
In persons with weak activity of the CYP2C19 isoenzyme, the concentration of escitalopram may be 2 times higher than in persons with high activity of this isoenzyme. Significant changes in the concentration of the drug with a weak activity of the CYP2D6 isoenzyme are not observed. T 1/2 after repeated use – 30 hours. In the main metabolites of escitalopram T 1/2 is longer. Clearance – 0.6 l / min. Escitalopram and its main metabolites are excreted by the liver and most of them by the kidneys, partly excreted in the form of glucuronides. T 1/2 and AUC increases in elderly patients.| F31 | Bipolar affective disorder |
| F32 | Depressive episode |
| F33 | Recurrent depressive disorder |
| F40 | Phobic anxiety disorders (including agoraphobia, social phobias) |
F41. 0 | Panic disorder [episodic paroxysmal anxiety] |
| F41.2 | Mixed anxiety and depressive disorder |
Dosing regimen
The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.
Take orally, regardless of the meal. Depending on the indications, a single dose is 10-20 mg / day. The maximum daily dose of is 20 mg. The duration of treatment is several months. When treatment is stopped, the dose should be gradually reduced over 1-2 weeks. in order to avoid the occurrence of the “withdrawal” syndrome.
For elderly patients (over 65 years of age) the recommended dose is 5 mg/day, the maximum daily dose of is 10 mg.
In case of impaired liver function, the recommended initial during the first 2 weeks. treatment is 5 mg / day. Depending on the individual response, the dose may be increased to 10 mg / day.
For patients with weak activity of the CYP2C19 isoenzyme, the recommended initial dose during the first 2 weeks. treatment – 5 mg / day. Depending on the individual response, the dose may be increased to 10 mg / day.
Side effect
from the nervous system: dizziness, weakness, insomnia, cramps, tremors, motor disorders, serotonin syndrome (agitation, tremor, myoclonus, hyperthermia), hallucinations, mania, confusion, agitation, anxiety, anxiety, anxiety , depersonalization, panic attacks, irritability, visual disturbances.
From the digestive system: nausea, vomiting, dryness of the oral mucosa, taste disturbances, loss of appetite, diarrhea, constipation, changes in liver function.
From the side of the cardiovascular system: orthostatic hypotension.
From the endocrine system: decreased secretion of ADH, galactorrhea.
From the reproductive system: decreased libido, impotence, ejaculation disorder, anorgasmia (in women).
From the urinary system: urinary retention.
Dermatological reactions: skin rash, itching, ecchymosis, purpura, increased sweating.
Allergic reactions: angioedema, anaphylactic reactions.
From the side of metabolism: hyponatremia, hyperthermia.
From the musculoskeletal system: arthralgia, myalgia.
Other: sinusitis, withdrawal syndrome (dizziness, headaches and nausea).
Contraindications for use
Concomitant use of MAO inhibitors, children and adolescents under 15 years of age, pregnancy, lactation, hypersensitivity to escitalopram.
Use during pregnancy and lactation
Use during pregnancy and lactation (breastfeeding) is contraindicated.
Use in hepatic dysfunction
Use with caution in cirrhosis of the liver.
Use for impaired renal function
Caution should be used in patients with renal insufficiency (CC less than 30 ml / min).
Use in children
Contraindicated in children and adolescents under 15 years of age.
Use in Elderly Patients
Caution should be used in elderly patients.
Special instructions
Caution should be used in patients with renal insufficiency (CC less than 30 ml / min), hypomania, mania, with pharmacologically uncontrolled epilepsy, with depression with suicidal attempts, diabetes mellitus, in elderly patients, with liver cirrhosis , with a tendency to bleeding, simultaneously with taking drugs that reduce the seizure threshold, causing hyponatremia, with ethanol, with drugs metabolized with the participation of isoenzymes of the CYP2C19 system.
Escitalopram should only be administered after 2 weeks. after the abolition of irreversible MAO inhibitors and 24 hours after the cessation of therapy with a reversible MAO inhibitor.
Non-selective MAO inhibitors can be prescribed no earlier than 7 days after discontinuation of escitalopram.
Some patients with panic disorder may experience an increase in anxiety at the beginning of treatment with escitalopram, which usually disappears within the next 2 weeks. treatment. To reduce the likelihood of anxiety, it is recommended to use low initial doses.
Escitalopram should be discontinued if seizures develop or become more frequent in pharmacologically uncontrolled epilepsy.
With the development of a manic state, escitalopram should be discontinued.
Escitalopram may increase blood glucose levels in diabetic patients, which may require dose adjustment of hypoglycemic agents.
Clinical experience with escitalopram indicates a possible increase in the risk of suicide attempts in the first weeks of therapy, and therefore it is very important to carefully monitor patients during this period.
Hyponatremia associated with a decrease in ADH secretion rarely occurs with escitalopram and usually disappears when it is discontinued.
With the development of serotonin syndrome, escitalopram should be immediately discontinued and symptomatic treatment prescribed.
Influence on the ability to drive vehicles and mechanisms
During the period of treatment, patients should avoid driving vehicles and other activities that require a high concentration of attention and speed of psychomotor reactions.
Drug interactions
When used simultaneously with MAO inhibitors, the risk of developing serotonin syndrome and serious adverse reactions increases.
Concomitant use with serotonergic drugs (including tramadol, triptans) may lead to the development of serotonin syndrome.
When used simultaneously with drugs that lower the seizure threshold, increases the risk of seizures.
Escitalopram enhances the effects of tryptophan and lithium preparations, increases the toxicity of St. John’s wort, the effects of drugs that affect blood coagulation (control of blood coagulation parameters is necessary).