What are the common and severe side effects of 5mg Lexapro. How does Lexapro affect adults and children differently. Can Lexapro cause weight changes or sexual problems. What is serotonin syndrome and how does it relate to Lexapro use.

Understanding Lexapro: An SSRI Antidepressant

Lexapro, known generically as escitalopram, is a widely prescribed medication for treating depression and generalized anxiety disorder. As a selective serotonin reuptake inhibitor (SSRI), Lexapro works by increasing serotonin levels in the brain, which helps alleviate symptoms of these mental health conditions.

Is Lexapro different from other antidepressants? Unlike monoamine oxidase inhibitors (MAOIs), which slow down the breakdown of serotonin and dopamine, SSRIs like Lexapro specifically target serotonin reuptake. This targeted action generally results in fewer side effects and drug interactions compared to MAOIs.

Common Side Effects of 5mg Lexapro

While Lexapro is generally well-tolerated, it can cause various side effects, particularly during the initial stages of treatment or when adjusting dosages. The 5mg dose is often used as a starting point or for maintenance therapy, and may still lead to some side effects.

• Nausea
• Sleepiness or insomnia
• Dizziness
• Anxiety
• Sexual problems (decreased libido, erectile dysfunction)
• Sweating
• Dry mouth
• Constipation
• Yawning

Do side effects differ between men and women? Generally, Lexapro’s side effects are similar across genders. However, individual experiences may vary, and some people might be more susceptible to certain side effects than others.

Lexapro’s Impact on Children and Adolescents

While Lexapro is approved for use in individuals 12 years and older, its effects on younger patients can differ from those seen in adults. Parents and caregivers should be aware of these potential differences.

Additional Side Effects in Younger Patients

• Increased thirst
• Abnormal increase in muscle movement or agitation
• Nosebleeds
• Urination difficulties
• Heavy menstrual periods
• Slowed growth and weight changes

Is Lexapro safe for children? While it can be effective for treating depression and anxiety in adolescents, close monitoring by a healthcare provider is crucial. The medication’s impact on growth and development should be carefully assessed throughout treatment.

Lexapro and Weight Changes: What to Expect

The relationship between Lexapro and weight changes is complex and can vary among individuals. Some people may experience weight gain, while others might lose weight.

Why do weight changes occur with Lexapro? Several factors can contribute:

1. Improved appetite due to better-managed depression
2. Changes in metabolism
3. Increased serotonin levels affecting appetite regulation

In adults, some sources suggest Lexapro may cause a small amount of weight gain. However, this could be attributed to the normalization of appetite as depression symptoms improve. Conversely, others may experience weight loss due to the appetite-suppressing effects of increased serotonin.

For children and adolescents, there have been reports of decreased appetite and weight loss associated with Lexapro use. Healthcare providers often monitor height and weight during treatment to ensure proper growth and development.

Sexual Side Effects of Lexapro

Sexual dysfunction is a common concern for many individuals taking SSRIs like Lexapro. These side effects can significantly impact quality of life and relationship satisfaction.

Common Sexual Side Effects

• Decreased libido
• Erectile dysfunction
• Difficulty achieving orgasm
• Delayed ejaculation

Are sexual side effects permanent? In most cases, sexual side effects are reversible upon discontinuation of the medication. However, some individuals may experience persistent effects. It’s crucial to discuss any concerns with a healthcare provider, as there are strategies to manage these side effects while maintaining the benefits of the medication.

Severe Side Effects and Boxed Warnings

While less common, Lexapro can potentially cause severe side effects that require immediate medical attention. The U.S. Food and Drug Administration (FDA) has issued a boxed warning, the most serious type of warning, for Lexapro.

Increased Risk of Suicidal Thoughts and Behaviors

The boxed warning highlights an increased risk of suicidal thoughts and behaviors, particularly in children, teenagers, and young adults. This risk is highest during the first few months of treatment or when dosages are changed.

What are the signs of increased suicide risk? Watch for:

• Attempts to commit suicide
• Acting on dangerous impulses
• Aggressive or violent behavior
• New or worsening depression or anxiety
• Extreme restlessness or irritability
• Panic attacks
• Insomnia
• Unusual changes in behavior or mood

If you or someone you know experiences these symptoms, seek immediate medical help or call emergency services.

Serotonin Syndrome: A Rare but Serious Concern

Serotonin syndrome is a potentially life-threatening condition that can occur when serotonin levels in the body become too high. While rare, it’s a serious concern for individuals taking SSRIs like Lexapro, especially when combined with other medications that affect serotonin levels.

Symptoms of Serotonin Syndrome

• Agitation or restlessness
• Confusion
• Rapid heart rate and high blood pressure
• Dilated pupils
• Loss of muscle coordination or twitching muscles
• Muscle rigidity
• Heavy sweating
• Diarrhea
• Headache
• Shivering
• Goose bumps

How can serotonin syndrome be prevented? To reduce the risk of serotonin syndrome, always inform your healthcare provider about all medications, supplements, and herbal products you’re taking. Avoid combining Lexapro with other serotonin-increasing substances without medical supervision.

Managing Lexapro Side Effects

While side effects can be concerning, many are manageable and may subside as your body adjusts to the medication. Here are some strategies to help cope with common side effects:

Nausea and Gastrointestinal Issues

• Take Lexapro with food
• Stay hydrated
• Eat smaller, more frequent meals
• Consider over-the-counter antacids (consult with your doctor first)

Sleep Disturbances

• Maintain a consistent sleep schedule
• Practice good sleep hygiene
• Avoid caffeine and electronic devices before bedtime
• Consider taking Lexapro in the morning if it causes insomnia

Sexual Side Effects

• Discuss dosage adjustments with your doctor
• Consider adding or switching to a different antidepressant
• Explore non-pharmaceutical strategies to enhance sexual function

When should you contact your healthcare provider about side effects? If side effects are severe, persistent, or significantly impacting your quality of life, it’s important to consult your doctor. They may adjust your dosage, recommend strategies to manage side effects, or consider alternative treatments.

Long-term Effects and Considerations

While Lexapro is generally considered safe for long-term use, it’s important to be aware of potential long-term effects and considerations.

Potential Long-term Effects

• Changes in weight
• Sexual dysfunction
• Emotional blunting or feeling emotionally “flat”
• Increased risk of bone fractures in older adults
• Potential impact on cognitive function in some individuals

Is it safe to take Lexapro indefinitely? For many people, the benefits of long-term Lexapro use outweigh the potential risks. However, regular check-ins with your healthcare provider are essential to monitor for any emerging concerns and ensure the medication continues to be effective.

Discontinuation Syndrome

Abruptly stopping Lexapro can lead to discontinuation syndrome, characterized by flu-like symptoms, sensory disturbances, and mood changes. Always work with your healthcare provider to develop a tapering plan if you need to discontinue Lexapro.

What are the symptoms of Lexapro discontinuation syndrome? Common symptoms include:

• Dizziness
• Nausea
• Fatigue
• Headache
• Irritability
• Electric shock sensations (brain zaps)
• Anxiety or agitation
• Insomnia or vivid dreams

To minimize the risk of discontinuation syndrome, your doctor will likely recommend a gradual tapering of the medication over several weeks or months.

Interactions and Precautions

Lexapro can interact with various medications, supplements, and even certain foods. Understanding these interactions is crucial for safe and effective treatment.

Common Drug Interactions

• Other antidepressants, particularly MAOIs
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Blood thinners
• Migraine medications
• Certain pain medications
• Some herbal supplements, such as St. John’s Wort

How can you minimize the risk of drug interactions? Always provide your healthcare provider with a complete list of all medications, supplements, and herbal products you’re taking. This includes over-the-counter medications and recreational substances.

Special Precautions

Certain individuals may need to exercise extra caution when taking Lexapro:

• Pregnant or breastfeeding women
• Elderly individuals
• People with a history of seizures
• Individuals with bipolar disorder
• Those with liver or kidney problems
• People with a history of bleeding disorders

Is Lexapro safe during pregnancy? While some studies suggest potential risks to the fetus, the benefits of treating severe depression during pregnancy may outweigh these risks. Always consult with your healthcare provider to make an informed decision based on your individual circumstances.

Alternatives to Lexapro

While Lexapro is effective for many people, it’s not the only option for treating depression and anxiety. If you’re experiencing intolerable side effects or find that Lexapro isn’t effective for you, there are alternatives to consider.

Other SSRIs

• Fluoxetine (Prozac)
• Sertraline (Zoloft)
• Paroxetine (Paxil)
• Citalopram (Celexa)

Other Classes of Antidepressants

• Serotonin-norepinephrine reuptake inhibitors (SNRIs)
• Atypical antidepressants
• Tricyclic antidepressants
• Monoamine oxidase inhibitors (MAOIs)

Non-Pharmaceutical Approaches

• Cognitive-behavioral therapy (CBT)
• Interpersonal therapy
• Mindfulness-based therapies
• Exercise and lifestyle changes
• Natural supplements (under medical supervision)

How do you decide which treatment is right for you? The choice of treatment should be made in consultation with your healthcare provider, taking into account your specific symptoms, medical history, and personal preferences. Sometimes, a combination of medication and therapy proves most effective in managing depression and anxiety.

In conclusion, while Lexapro can be an effective treatment for depression and anxiety, it’s essential to be aware of potential side effects and to work closely with your healthcare provider throughout your treatment journey. By staying informed and maintaining open communication with your doctor, you can maximize the benefits of Lexapro while minimizing potential risks.

What are the side effects of Lexapro?

Doctors prescribe Lexapro for anxiety and depression. It can cause nausea, dizziness, and other side effects in adults. Lexapro can also potentially cause severe side effects, such as suicidal thoughts, and make depression worse.

If you have depression or generalized anxiety disorder, your doctor may want to give you Lexapro. This drug can be very effective in treating either condition. But like all drugs, it may cause side effects. Some of these may only be bothersome, while others may be severe and impact your health.

Learning about the side effects can help you decide if the drug is right for you. Here’s an overview of the side effects Lexapro can cause.

Lexapro is a prescription drug. It’s available as an oral tablet and an oral liquid solution. It’s approved for use in adults and children 12 years and older.

The medication belongs to the class of drugs called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of the chemical serotonin in your brain. Having more serotonin helps decrease the symptoms of depression and anxiety. Lexapro is not considered a monoamine oxidase inhibitor (MAOI). MAOIs work by slowing down the breakdown of serotonin and dopamine, another chemical in your brain. This also helps alleviate symptoms of depression. However, MAOIs have a higher risk of side effects and drug interactions than SSRIs such as Lexapro.

SSRIs, including Lexapro, are tolerated well compared to other types of antidepressants. In general, you may have more side effects if you take a higher dosage of the drug. At a high dosage, Lexapro is more likely to cause gastrointestinal side effects, such as diarrhea.

Common side effects

The side effects of Lexapro seem to be the same in both men and women. The side effects are slightly different for adults and children.

Adult side effects can include:

• nausea
• sleepiness
• weakness
• dizziness
• anxiety
• sleeping trouble
• sexual problems, such as decreased sex drive and erectile dysfunction
• sweating
• shaking
• loss of appetitive
• dry mouth
• constipation
• infection
• yawning

The side effects for children and adolescents can include the above, plus:

• increased thirst
• abnormal increase in muscle movement or agitation
• nosebleeds
• trouble urinating
• heavy menstrual periods
• slowed growth and weight change

There have been some cases of decreased appetite and weight loss with the use of Lexapro in children and adolescents. Your child’s doctor may check their height and weight during treatment.

People with depression tend to have a low appetite and reduced body weight. In adults, some sources say Lexapro may cause a small amount of weight gain. However, if you gain weight, your weight may just be evening out because your depression is better managed and your appetite has returned. Other people lose weight when they’re taking Lexapro. The increase in serotonin may lead to loss of appetite.

Most of these side effects are mild. They should eventually go away on their own without treatment. If they’re more severe or don’t go away, tell your doctor.

Boxed warning side effects

A boxed warning is the most serious warning from the U.S. Food and Drug Administration (FDA).

Lexapro may increase suicidal thoughts or actions. This risk is higher in in children, teenagers, or young adults. This is more likely to happen within the first few months of treatment or during dosage changes.

Call your doctor right away if you have any of the following symptoms, or call 911 or local emergency services if the symptoms are new, worse, or worrisome:

• attempts to commit suicide
• acting on dangerous impulses
• aggressive or violent actions
• thoughts about suicide or dying
• new or worse depression
• new or worse anxiety or panic attacks
• feeling restless, angry, or irritable
• trouble sleeping
• increased activity (doing more than what is normal for you)
• other unusual changes in your behavior or mood

Other serious side effects

Lexapro can also cause other serious side effects. Call your doctor right away if you have serious side effects. Call 911 or local emergency services if your symptoms feel life-threatening or if you think you’re having a medical emergency.

Severe allergic reactions

You should not take Lexapro if you’re allergic to it, its ingredients, or the antidepressant Celexa. Symptoms can include:

• breathing trouble
• swelling of your face, tongue, eyes, or mouth
• severe rash, hives (itchy welts), or blisters that may come on with fever or joint pain

Seizures or convulsions

There have been reports of some people having seizures while taking Lexapro. People with a history of seizures are at higher risk.

Serotonin syndrome

This is a serious condition. It happens when the levels of serotonin in your body get too high. It’s more likely to occur if you also take other drugs that increase serotonin, such as other antidepressants or lithium. Symptoms can include:

• agitation
• hallucinations (seeing or hearing things that aren’t real)
• coma (loss of consciousness)
• coordination problems, overactive reflexes, or muscle twitching
• racing heart rate
• high or low blood pressure
• sweating or fever
• nausea, vomiting, or diarrhea
• muscle stiffness

Low salt levels

Lexapro may cause low salt levels in your body. This may be more likely to occur in seniors, people who take water pills, or people who are dehydrated. This side effect may cause:

• headache
• confusion
• trouble concentrating
• thinking or memory problems
• weakness
• unsteadiness that can lead to falls
• seizures

Manic episodes

If you have bipolar disorder, Lexapro may cause you to have a manic episode. Taking Lexapro without another drug for bipolar disorder may trigger an episode. Symptoms can include:

• greatly increased energy
• severe sleeping trouble
• racing thoughts
• reckless behavior
• unusually grand ideas
• excessive happiness or irritability
• talking quickly or more than normal

Vision problems

Lexapro may dilate your pupils. This may trigger a glaucoma attack, even if you don’t have a history of eye problems. Symptoms can include:

• eye pain
• changes in your vision
• swelling or redness in or around your eye

Side effects with other health conditions

If you have certain health conditions, you likely should not take Lexapro. In some cases, your doctor may lower your dosage or watch you more closely during your treatment with it. Tell your doctor if you have any of the following health conditions before taking Lexapro.

• A history of suicidal thoughts or behaviors—Lexapro can increase the risk of suicidal thinking and behavior, especially in children, teens, and young adults.
• Bipolar disorder—if you take Lexapro without taking other medications for bipolar disorder, Lexapro may bring on a manic episode.
• Seizures—this drug may cause seizures and make your seizure disorder worse.
• Glaucoma—this drug may bring on a glaucoma attack.
• Low salt levels—Lexapro can further lower your salt levels.
• Pregnancy—it isn’t known if Lexapro will harm your unborn baby.
• Breastfeeding—Lexapro may pass into breast milk and cause side effects in a child who is breastfed.

Certain medications can interact with Lexapro. Be sure to tell your doctor about all over-the-counter and prescription drugs, supplements, and herbs you take. Lexapro may interact with the following drugs:

• blood thinners such as warfarin to increase your risk of bleeding
• nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin to increase your risk of bleeding
• other drugs used to treat depression to increase the level of serotonin in your body, which can cause serotonin syndrome

Lexapro is a powerful drug used to treat depression and anxiety. While it can be very effective, it may also cause side effects. Be sure to tell your doctor about other health conditions you have and medications you take before starting Lexapro. This information can help your doctor reduce your chance of side effects. Also tell your doctor if you do have any side effects. If you can’t tolerate the effects, your doctor may change your medication. Keep in mind that Lexapro and other drugs in its class cause many of the same side effects.

What are they and are they serious?

Lexapro, the brand name of escitalopram, is an antidepressant. It may cause side effects ranging from mild to severe. Several factors can influence these side effects, such as age and taking other medications.

Lexapro is a selective serotonin reuptake inhibitor (SSRI). SSRIs work by slowing the reabsorption of serotonin back into nerve cells to maintain higher serotonin levels in the brain.

Serotonin is a chemical your body produces. Doctors believe that it helps stabilize mood and causes happiness and a sense of well-being.

Doctors prescribe Lexapro to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD).

People should take Lexapro as follows:

For MDD, adults and adolescents aged 12⁠–17 ⁠years should take 10 milligrams (mg) of Lexapro daily, with or without food. The dosage may increase to 20 mg daily following a doctor’s recommendation.

For GAD, adults should take 10 mg of Lexapro daily, with or without food. If necessary, a doctor can recommend increasing the daily amount to 20 mg after a minimum of one week.

This article provides information on the side effects of Lexapro, including interactions with different drugs and when to see a doctor.

Lexapro side effects may vary among different people. Many common side effects can improve within the first 2 weeks after use.

Adults

In adults, common side effects of Lexapro include:

• nausea
• diarrhea
• trouble sleeping (insomnia)
• sleepiness
• fatigue
• dizziness
• anxiety
• sexual problems, such as delayed ejaculation, painful erections, or difficulty with orgasms
• sweating
• reduced appetite
• dry mouth
• constipation
• common cold
• sinusitis

According to the National Alliance on Mental Illness (NAMI), many common side effects of Lexapro may improve within 2 weeks of taking the medication. However, the sexual side effects of taking Lexapro often do not improve.

Children

Doctors do not recommend Lexapro for children under the age of 12 years. A 2014 study of its effects on children aged 7–11 years found half experienced side effects such as:

• abdominal pain
• diarrhea
• nausea
• vomiting
• increased appetite
• common cold
• dizziness
• headache
• insomnia
• stuffy nose (nasal congestion)

In the above study, one participant also experienced mania, while another had suicidal ideation.

Doctors may prescribe Lexapro to adolescents between the ages of 12⁠–17 for the treatment of MDD. Side effects for this age group are similar to those for adults. Side effects that may be more common among people aged 12–17 include:

• vomiting
• back pain
• urinary tract infection
• stuffy nose

Pregnancy

According to NAMI, pregnant people who take SSRIs in their second and third trimesters have a risk of their baby being born before 37 weeks, before it is fully developed.

NAMI also notes that taking SSRIs during the second half of pregnancy slightly increases the risk of the infant developing the serious condition known as persistent pulmonary hypertension. The overall risk remains very small, though. The condition happens in less than 1% of pregnancies with SSRI treatment.

The evidence on certain pregnancy complications is mixed. For example, a large 2015 study found that people who take SSRIs in pregnancy have a lower risk of birth before 37 weeks and cesarean section than people who have depression or other mental health conditions but do not take SSRIs.

This means that while there are risks linked to SSRI use during pregnancy, untreated depression during pregnancy may also come with an increased risk of certain complications.

People who are pregnant or trying to conceive should consult their doctor when considering Lexapro treatment before or during pregnancy. It is important to discuss a person’s specific medical history and the possible risks and benefits before deciding whether to take this medication.

Breastfeeding and chestfeeding

People who are breastfeeding or chestfeeding can pass Lexapro to babies via their breast milk. Usually, this does not cause side effects for infants. However, in rare cases, babies may become restless, irritable, or sick.

If a person notices these changes in their baby, it is important to talk with a doctor or pharmacist right away.

A boxed warning is the strongest warning the Food and Drug Administration (FDA) can require a drug to have.

The boxed warning for Lexapro indicates that it may carry a risk of suicidal thoughts and behavior in children, adolescents, and young adults. The boxed warning also notes that the FDA has not approved Lexapro for children younger than 12 years old.

Suicidal thoughts or behaviors may be more likely to occur in the first few months of taking the drug or if the dose changes. It is important to look out for new or worsening thoughts or behaviors related to self-harm or suicide.

If a person’s depression gets worse, or they experience thoughts or behaviors related to suicide, they should contact their doctor immediately.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

• Ask the tough question: “Are you considering suicide?”
• Listen to the person without judgment.
• Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
• Stay with the person until professional help arrives.
• Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Click here for more links and local resources.

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Lexapro may produce other side effects that can be serious or life threatening. If a person suspects they are experiencing a serious side effect, they should seek immediate medical attention.

Some serious side effects of Lexapro include:

Serotonin syndrome

Serotonin syndrome, or serotonin toxicity, is a potentially life threatening condition that occurs due to an excess of serotonin in the body.

This condition can cause changes to a person’s mental state, such as agitation, hallucinations, and delirium.

Other symptoms of serotonin syndrome include:

• coma
• rapid heartbeat
• sudden change in blood pressure
• dizziness
• excessive sweating
• flushing
• excessively high body temperature (hyperthermia)
• tremors
• rigid muscles
• muscle spasms or twitching
• loss of coordination
• seizures
• nausea
• vomiting
• diarrhea

To reduce the risk of serotonin syndrome with Lexapro, it is important to talk with a doctor about any other drugs a person may be taking.

Allergies

Although it is rare, Lexapro may cause severe allergic reactions, which can result in:

• trouble breathing
• wheezing
• swelling of the face, tongue, mouth, or throat
• itching
• rash, hives, or blisters on the skin

If a person is having a serious allergic reaction, get emergency medical help.

Mania or hypomania

In people with bipolar disorder, Lexapro can increase the likelihood of a manic episode.

Symptoms of a manic episode include:

• very elevated mood, such as feeling extremely happy
• very high self-esteem or overconfidence
• irritability
• racing thoughts
• reckless behavior
• talking more or faster than usual
• being easily distracted
• needing less sleep than usual

People with a personal or family history of manic episodes or bipolar disorder should discuss this with their doctor before taking Lexapro.

Low sodium levels in the blood

People who take Lexapro may be at a greater risk of experiencing low sodium levels in the blood. This is more common for older adults.

Symptoms of this condition include:

• headache
• weakness
• feeling unsteady or having falls
• confusion
• memory problems
• trouble concentrating

In serious cases, low blood sodium levels can lead to symptoms such as hallucinations, fainting, seizures, and coma. If a person does not receive treatment, the condition can be life threatening.

Lexapro can trigger adverse reactions when taken with other medications.

According to NAMI, people should not have this medication within 2 weeks of taking monoamine oxidase inhibitors (MAOIs), another type of antidepressant.

The antipsychotic medication pimozide can also cause serious heart problems when taken with Lexapro.

Lexapro may increase a person’s chances of experiencing abnormal bleeding or bruising, especially when taken with aspirin, blood thinners, or nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. People who take these drugs with Lexapro may experience:

• unusual bruising
• gastrointestinal bleeding
• nosebleeds
• broken capillaries
• life threatening bleeding

Lexapro may also interact with drugs and supplements such as:

• triptans
• drugs that affect the central nervous system
• alcohol
• cimetidine
• digoxin
• lithium
• sumatriptan
• theophylline
• carbamazepine
• triazolam
• ketoconazole
• ritonavir
• metoprolol
• St. John’s Wort
• amphetamines
• fentanyl
• lithium
• warfarin

People should talk with their doctor about any other medications or supplements they take before using Lexapro. A person should avoid consuming alcohol while taking Lexapro.

Lexapro can cause issues in people with the following health conditions:

• Bipolar disorder: A person with bipolar disorder is at risk of experiencing a manic episode when taking Lexapro.
• Angle-closure glaucoma: People who are at risk of angle-closure glaucoma may experience a glaucoma episode due to the pupil dilation that occurs when taking Lexapro.
• Seizures: Doctors do not know whether Lexapro increases seizure risk for people who have seizure conditions. However, the medication itself can cause seizures in some people.
• Heart problems: Lexapro can cause the heart to beat too fast or irregularly, so it may not be appropriate for people with heart problems.

A person who wishes to stop taking Lexapro should speak with their doctor first. Stopping Lexapro too quickly may cause:

• anxiety
• irritability
• high or low mood
• changes in sleeping habits
• inability to control one’s emotions (emotional lability)
• headache
• dizziness
• agitation
• confusion
• feelings of electric shock

Slowly stopping treatment with a doctor’s supervision can help to lower the risk of these side effects.

A 2017 study in China found that 87% of people taking Lexapro for MDD showed good or excellent improvement after 6 weeks. People with milder depression at the start of the study had a greater reduction in symptoms than people with more severe depression.

Clinical trials have shown Lexapro to be effective. A 2019 research review and meta-analysis found that escitalopram, the active ingredient in Lexapro, was 68% more likely to improve MDD than a placebo medication.

In the same 2019 study, researchers found escitalopram to be more effective than some other antidepressant medications, such as fluoxetine. However, the authors note that their research does not address individual factors that help a doctor decide which medication is right for a particular person.

Is taking Lexapro worth it?

Lexapro may help adolescents and adults with MDD, and adults with GAD, find relief from the symptoms of these conditions.

Like other medications, it can cause some side effects and drug interactions. However, for some people, the benefits may outweigh the possible adverse effects.

Depression and anxiety may have major effects on a person’s quality of life. While it can be difficult to take the first steps to reach out for help, treatments are available that can help a person feel better.

It is important for a person to talk with a doctor to determine whether Lexapro is the right treatment for their specific needs.

A person who takes Lexapro should contact their doctor if they have any symptoms that cause discomfort or do not clear up.

If a person notices any serious side effects or sudden changes in their mood or thinking, they should seek immediate medical help.

Generally, common side effects from Lexapro may improve within 2 weeks of taking the drug.

Although some side effects can be serious, these reactions are rare. If a person has concerns about Lexapro, they should speak with their doctor.

Many medications come with side effects, so they may be impossible to avoid entirely. However, people should make sure they do not take any medications that could interfere with Lexapro to minimize possible side effects.

Certain health conditions may also increase the chance of side effects, so a person should discuss their health history with a doctor before starting Lexapro.

A person can also speak with a doctor about lowering their Lexapro dosage to help reduce adverse effects.

Lexapro can trigger side effects in some people. These can range from mild to severe, although more severe side effects are rare.

A person should discuss other medications they take before starting Lexapro. They should also tell their doctor about any other health conditions they may have.

If a person experiences serious adverse effects when taking Lexapro, they should seek medical attention immediately.

Escitalopram instructions for use: indications, contraindications, side effects – description Escitalopram tab., cover. film coated, 10 mg: 10, 14, 28, 30 or 56 pcs. (44993)

💊 Composition of Escitalopram ✅ Use of Escitalopram Keep for yourself Search for analogues Interaction Description of the active ingredients of the preparation Escitalopram (Escitalopram) The scientific information provided is general and cannot be used to make decisions. decisions about the use of a particular drug. Update date: 2020.07.03 Marketing authorization holder: Berezovsky Pharmaceutical Plant, CJSC (Russia) ATX code: N06AB10 (Escitalopram) Active substance: escitalopram (escitalopram) Rec.INN WHO registered Dosage form Escitalopram Tab., coated film coated, 10 mg: 10, 14, 28, 30 or 56 pcs. reg. No.: LP-003256 from 15. 10.15 – Active Re-registration date: 01/24/22 Release form, packaging and composition drug Escitalopram Film-coated tablets white or off-white, round, biconvex, scored on one side; on a cross section, the cores of the tablets are white or almost white. Excipients : microcrystalline silicified cellulose (prosolv SMCC) – 124.33 mg, including: [microcrystalline cellulose – 121.843 mg, colloidal silicon dioxide – 2.487 mg], croscarmellose sodium – 6.9 mg, talc – 4.5 mg, magnesium stearate – 1.5 mg. The composition of the film shell: hypromellose – 4.5 mg, macrogol (polyethylene glycol) – 0.9 mg, talc – 1.25 mg, titanium dioxide (E171) – 0.85 mg). 7 pcs. – cellular contour packings (2) – packs of cardboard. 7 pcs. – cellular contour packings (4) – packs of cardboard. 7 pcs. – cellular contour packings (8) – packs of cardboard. 10 pcs. – cellular contour packings (1) – packs of cardboard. 10 pcs. – cellular contour packings (3) – packs of cardboard. 28 pcs. – polymer cans (1) – packs of cardboard. Clinical and pharmacological group: Antidepressant Pharmacotherapeutic group: Antidepressant Pharmacological action Antidepressant. Selectively inhibits the reuptake of serotonin; increases the concentration of the neurotransmitter in the synaptic cleft, enhances and prolongs the action of serotonin on postsynaptic receptors. Escitalopram practically does not bind to serotonin (5-HT), dopamine (D 1 and D 2 ) receptors, α-adreno-, m-cholinergic receptors, as well as benzodiazepine and opioid receptors. The antidepressant effect usually develops after 2-4 weeks. after the start of treatment. The maximum therapeutic effect of the treatment of panic disorders is achieved approximately 3 months after the start of treatment. Pharmacokinetics Absorption is independent of food intake. Bioavailability – 80%. The time to reach C max in plasma is 4 hours. The kinetics of escitalopram is linear. C ss achieved after 1 week. The average C ss is 50 nmol / l (from 20 to 125 nmol / l) and is achieved at a dose of 10 mg / day. Apparent V d – from 12 to 26 l / kg. Plasma protein binding – 80%. Metabolized in the liver to active demethylated and didemethylated metabolites. After repeated use, the average concentration of demethyl and didemethyl metabolites is 28-31% and less than 5%, respectively, of the concentration of escitalopram. Metabolism of escitalopram with the formation of a demethylated metabolite occurs mainly with the participation of CYP2C19 isoenzymes, CYP3A4 and CYP2D6. In persons with weak activity of the CYP2C19 isoenzyme, the concentration of escitalopram may be 2 times higher than in persons with high activity of this isoenzyme. Significant changes in the concentration of the drug with a weak activity of the CYP2D6 isoenzyme are not observed. T 1/2 after repeated use – 30 hours In the main metabolites of escitalopram T 1/2 is longer. Clearance – 0.6 l / min. Escitalopram and its main metabolites are excreted by the liver and most of them by the kidneys, partly excreted in the form of glucuronides. T 1/2 and AUC increases in elderly patients. Indications of the active substances of the drug Escitalopram Depression, panic disorders (including with agoraphobia). Open list of ICD-10 codes F31 Bipolar affective disorder F32 Depressive episode F33 Recurrent depressive disorder F40 Phobic anxiety disorders (including agoraphobia, social phobias) F41. 0 Panic disorder [episodic paroxysmal anxiety] F41.2 Mixed anxiety and depressive disorder Dosage regimen The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. Take orally, regardless of food intake. Depending on the indications, a single dose is 10-20 mg / day. The maximum daily dose of is 20 mg. The duration of treatment is several months. When treatment is stopped, the dose should be gradually reduced over 1-2 weeks. in order to avoid the occurrence of the “withdrawal” syndrome. For elderly patients (over 65 years old) the recommended dose is 5 mg/day, the maximum daily dose of is 10 mg. In case of impaired liver function, the recommended initial during the first 2 weeks. treatment is 5 mg / day. Depending on the individual response, the dose may be increased to 10 mg / day. For patients with weak activity of the CYP2C19 isoenzyme, the recommended initial dose during the first 2 weeks. treatment – 5 mg / day. Depending on the individual response, the dose may be increased to 10 mg / day. Side effect from the nervous system: Dizziness, weakness, insomnia or drowsiness, cramps, tremors, motor disorders, serotonin syndrome (agitation, tremor, myoclonus, hyperthermia), hallucinations, mania, confusion, anxiety, anxiety, anxiety, anxiety , depersonalization, panic attacks, irritability, visual disturbances. From the digestive system: nausea, vomiting, dryness of the oral mucosa, taste disturbances, loss of appetite, diarrhea, constipation, changes in liver function. From the side of the cardiovascular system: orthostatic hypotension. From the endocrine system: decreased secretion of ADH, galactorrhea. From the reproductive system: decreased libido, impotence, ejaculation disorder, anorgasmia (in women). From the urinary system: urinary retention. Dermatological reactions: skin rash, itching, ecchymosis, purpura, increased sweating. Allergic reactions: angioedema, anaphylactic reactions. From the side of metabolism: hyponatremia, hyperthermia. From the musculoskeletal system: arthralgia, myalgia. Other: sinusitis, withdrawal syndrome (dizziness, headaches and nausea). Contraindications for use Simultaneous use of MAO inhibitors, children and adolescents under 15 years of age, pregnancy, lactation, hypersensitivity to escitalopram. Use during pregnancy and lactation Use during pregnancy and lactation (breastfeeding) is contraindicated. Use in hepatic impairment Use with caution in cirrhosis of the liver. Use for impaired renal function C should be used with caution in patients with renal insufficiency (CC less than 30 ml / min). Use in children Contraindicated in children and adolescents under 15 years of age. Use in the elderly Caution should be used in elderly patients. Special instructions Caution should be used in patients with renal insufficiency (CC less than 30 ml / min), hypomania, mania, with pharmacologically uncontrolled epilepsy, with depression with suicidal attempts, diabetes mellitus, in elderly patients, with liver cirrhosis , with a tendency to bleeding, simultaneously with taking drugs that reduce the seizure threshold, causing hyponatremia, with ethanol, with drugs metabolized with the participation of isoenzymes of the CYP2C19 system. Escitalopram should only be administered after 2 weeks. after the abolition of irreversible MAO inhibitors and 24 hours after the cessation of therapy with a reversible MAO inhibitor. Non-selective MAO inhibitors can be prescribed no earlier than 7 days after discontinuation of escitalopram. In some patients with panic disorder, an increase in anxiety may be observed at the beginning of treatment with escitalopram, which usually disappears within the next 2 weeks. treatment. To reduce the likelihood of anxiety, it is recommended to use low initial doses. Escitalopram should be discontinued if seizures develop or become more frequent in pharmacologically uncontrolled epilepsy. With the development of a manic state, escitalopram should be discontinued. Escitalopram can increase the concentration of glucose in the blood in diabetes mellitus, which may require dose adjustment of hypoglycemic drugs. Clinical experience with escitalopram indicates a possible increase in the risk of suicide attempts in the first weeks of therapy, and therefore it is very important to carefully monitor patients during this period. Hyponatremia associated with a decrease in ADH secretion rarely occurs with escitalopram and usually disappears when it is discontinued. With the development of serotonin syndrome, escitalopram should be immediately discontinued and symptomatic treatment prescribed. Influence on the ability to drive vehicles and mechanisms During the period of treatment, patients should avoid driving vehicles and other activities that require a high concentration of attention and speed of psychomotor reactions. Drug interactions When used simultaneously with MAO inhibitors, the risk of developing serotonin syndrome and serious adverse reactions increases. Concomitant use with serotonergic agents (including tramadol, triptans) may lead to the development of serotonin syndrome. When used simultaneously with drugs that lower the seizure threshold, increases the risk of seizures. Escitalopram enhances the effects of tryptophan and lithium preparations, increases the toxicity of St. John’s wort, the effects of drugs that affect blood coagulation (control of blood coagulation parameters is necessary). Drugs that are metabolized with the participation of the CYP2C19 isoenzyme (including omeprazole), and are also strong inhibitors of CYP3A4 and CYP2D6 (including flecainide, propafenone, metoprolol, desipramine, clomipramine, nortriptyline, risperidone, thioridazine, haloperi dol) , increase the concentration of escitalopram in the blood plasma. Escitalopram increases the plasma concentration of desipramine and metoprolol by 2 times. Keep If you want to place a link to the description of this drug – use this code Escitalopram . Description of the drug in the reference book Vidal.

Lexapro: common and serious side effects

Disclaimer

If you have any medical questions or concerns, contact your doctor. Articles in the Health Guide are based on peer-reviewed research and information from medical societies and government agencies. However, they are not a substitute for professional medical advice, diagnosis or treatment.

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Lexapro side effects

Passing a day when you are depressed is already a lot to achieve. Depression doesn’t just affect the mind; it also affects the body. Depression and chronic pain are closely linked (Lee, 2018). So it’s only natural if you want to know if your antidepressant is causing side effects, what they are, and how likely you are to experience them when you’re already dealing with depression.

Vitals

• Lexapro is the brand name for the drug escitalopram. It is FDA approved for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD).
• Generic Lexapro has the same active ingredient as the branded version.
• Common side effects of Lexapro include fatigue, nausea, sleep problems, and sexual dysfunction.
• Lexapro may cause more serious side effects such as serotonin syndrome and worsening depression in children and adolescents.

What is Lexapro?

Lexapro is a prescription drug from a group of drugs called selective serotonin reuptake inhibitors, or SSRIs. SSRIs are used to treat depression, anxiety, and other mood disorders. Researchers believe that depression is caused by an imbalance of chemicals in our brain, and globally by SSRIs. are considered first line treatment (Bauer, 2009).

Lexapro is specifically approved for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD), but it may be used off-label by healthcare professionals to treat obsessive-compulsive disorder (OCD) (Zutshi, 2007).

Lexapro is the brand name for escitalopram oxalate. Although escitalopram can be confused with alprazolam, a common anxiety medication sold under the brand name Xanax, these medications are not the same. Previously, Lexapro could only be manufactured by Forest Laboratories Inc. (in partnership with pharmaceutical company Lundbeck).

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Lundbeck has made Lexapro available as a tablet or oral solution. Tablets come in three dosages: 5 mg, 10 mg and 20 mg. The oral solution is only available in one strength equivalent to 5 mg (FDA, n.d.). Lexapro was launched in 2002, but its patent expired in March 2012, which meant that other companies could seek approval from the U.S. Food and Drug Administration (FDA) to manufacture and market escitalopram (Llamas, 2013) .

What are SSRIs and how do they work?

Depression can be treated in many ways, and there are several types of antidepressants. Medications used to treat this mood disorder include (FDA, 2009):

• Selective serotonin reuptake inhibitors (SSRIs)
• Monoamine oxidase inhibitors (MAOIs)
• Tricyclic antidepressants
• Atypical antidepressants pressants
• Selective serotonin and norepinephrine reuptake inhibitors (SNRI)

Many different types of SSRIs also exist, including: 0303 Fluoxetine (trade name Prozac, Sarafem, Symbiax)

In the brain, chemical messengers called neurotransmitters carry messages from brain cell to brain cell. Serotonin is one type of neurotransmitter. SSRIs work by keeping serotonin levels high between brain cells. SSRIs are thought to treat certain mental illnesses in this way.

Possible side effects of Lexapro

Here are the most common potential side effects of Lexapro and how often they occurred in participants with MDD in clinical trials testing the drug’s efficacy and safety:

• Nausea (15%)
• Sleep problems (9%)
• Ejaculation disorder (9%)
• Diarrhea (8%)
• Drowsiness (6%)
• Dry mouth (6%)
• Increased sweating (5%)
• Dizziness (5%)
• Flu-like symptoms (5%)
• Tiredness/fatigue (5%)
• Loss of appetite (3%)
• Low sex drive (3%)

These common Lexapro side effects also appear to be dose-dependent, meaning that you are more likely to experience these side effects if you take 20mg than 10mg. Other potential side effects of Lexapro were noted, although they were not observed in more than 2% of the participants in these studies. These symptoms included weight gain, blurred vision, muscle stiffness, and joint pain (FDA, 2017).

In clinical trials, 8% of participants who received Lexapro for GAD and 6% of participants who received prescription drug for MDD discontinued the drug due to side effects. MDD treatment studies have shown that more people stopped using Lexapro when they were given 20mg rather than 10mg daily.

If you are experiencing side effects from Lexapro, it is important to talk to your doctor before stopping your medication. If you stop taking Lexapro suddenly, you may experience withdrawal symptoms such as nightmares, irritability, headache, nausea, dizziness, or vomiting (NAMI, 2016).

Side effects of Lexapro in men and women

Unfortunately, sexual dysfunction is a common side effect of SSRI treatment. In fact, studies have shown that this specific side effect occurs in 20–70% of patients taking these medications and is a common reason patients want to stop treatment (Osis, 2010). These sexual side effects include:

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• Erectile dysfunction
• Ejaculation disorder (delayed ejaculation)
• Decreased libido

Although researchers have noted this effect with many SSRIs, paroxetine causes the highest rate of sexual dysfunction. Patients taking SSRIs who experience changes in their sex drive or sexual satisfaction should discuss these changes with their health care providers. In some cases, bupropion, mirtazapine, vilazodone, vortioxetine, or SNRIs may be good alternative treatments (Jing, 2016).

Lexapro drug interactions

You should not take Lexapro with certain medicines, including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. John’s wort. You should also avoid prescription drugs that affect the breakdown of serotonin in the body, especially MAOIs such as rasagiline and tranylcypromine. Combining these drugs increases the risk of a serious condition called serotonin syndrome. This syndrome occurs when there is too much active serotonin in your body. It can cause mild symptoms such as tremors and diarrhea, but can also be life-threatening (Volpi-Abadie, 2013).

You should also be careful when taking Lexapro with any blood-thinning medications, from real prescription blood thinners like warfarin to over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen and naproxen. Lexapro may increase your risk of bleeding if you take these medicines.

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Lexapro Warnings

It may take some time to experience the full effects of Lexapro and understand the extent to which you experience side effects. Lexapro may cause drowsiness and may affect your ability to make decisions or react to events. For this reason, it is recommended that you do not drive or operate heavy machinery until you understand how this antidepressant affects you.

For the same reason, standard medical advice is to avoid drinking alcohol while taking Lexapro. Alcohol similarly affects your ability to make decisions and react to events. Clinical trials have not shown that Lexapro aggravates these effects of alcohol, but it is possible that the combination could be dangerous in certain situations.

Patients and their families should be monitored for any behavioral changes, including worsening depression, panic attacks, and suicidal ideation, when Lexapro is started or after a dose change. Children, teenagers, and young adults are at increased risk for these side effects. In fact, the FDA has required all manufacturers of antidepressants to update their SSRI drug package information to include these risks found in short-term studies (FDA, 2018).

When to Seek Medical Care

There are serious potential side effects of antidepressants such as Lexapro. You should seek immediate medical attention if you experience increased depression, anxiety, or suicidal thoughts. Contact someone if you notice unusual changes in mood or behavior. You should also call your doctor right away if you experience (FDA, 2017):

• Any symptoms of serotonin syndrome, including coordination problems, hallucinations, palpitations, sweating, nausea, vomiting, muscle stiffness, or high or low blood pressure. pressure.
• Any symptoms of an allergic reaction, including swelling of the face, lips or tongue, difficulty breathing, rash or hives.
• Seizures
• Abnormal bleeding
• Manic episodes, which may include spasmodic thoughts, increased energy, reckless behavior, and talking more or faster than usual.
• Changes in appetite or weight, especially in children and adolescents.
• Problems with vision, including eye pain, swelling or redness around the eyes.

Recommendations

1. Bauer, M., Bshore, T., Pfennig, A., Whybrow, P.K., Angst, J., Versiani, M.,. . . WFSBP Working Group on Unipolar Depres. (2007). World Federation of Societies for Biological Psychiatry (WFSBP) guidelines for the biological treatment of unipolar depressive disorders in primary care. World Journal of Biological Psychiatry, 8(2), 67-104. DOI: 10.1080 / 15622970701227829 Retrieved from https://www.tandfonline.com/doi/full/10.1080/15622970701227829
2. Food and Drug Administration (FDA). (no data). Lexapro (escitalopram oxalate) Tablets / Oral solution label. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021323s032,021365s023lbl.pdf
3. Food and Drug Administration (FDA). (2017, January). Lexapro (escitalopram oxalate). Extracted from https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021323s047lbl.pdf
4. Food and Drug Administration (FDA). (2009, September). Medications to help you: depression. Retrieved from https://www.fda.gov/media/77381/download
5. Food and Drug Administration (FDA). (2018, February 05). Suicidality in children and adolescents treated with antidepressants. Retrieved from https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/suicidality-children-and-adolescents-being-treated-antidepressant-medications
6. Jing, E., Straw-Wilson, K. (2016). Sexual dysfunction in selective serotonin reuptake inhibitors (SSRIs) and possible solutions: a review of the narrative literature. Psychiatrist, 6(4), 191–196. DOI: 10.9740 / mhc.2016.07.191. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29955469/
7. Lee, H., Choi, E.J., Nah, F.C., Yun, I.Yu., and Lee, P B. (2018). Prevalence of unrecognized depression in patients with chronic pain without a history of psychiatric illness. Korean Journal of Pain, 31(2), 116-124. DOI: 10.3344/kjp.2018.31.2.116. Extracted from https://pubmed.ncbi.nlm.nih.gov/29686810/
8. Lama, M. (January 21, 2013). Manufacturer Lexapro is struggling with patent expiration, lawsuits are mounting. Retrieved from https://www.drugwatch.com/news/2013/01/21/lexapro-manufacturer-struggles-as-patent-expires-lawsuits-grow/
9. National Alliance on Mental Illness (NAMI).