7.5 325 norco. Hydrocodone and Acetaminophen: Proper Use, Indications, and Administration Guide
What are the proper uses of hydrocodone and acetaminophen combination. How does this medication work for pain management. What are the recommended dosages and administration methods. How can healthcare providers ensure safe and effective use of this medication.
Understanding Hydrocodone and Acetaminophen Combination
Hydrocodone and acetaminophen combination is a widely prescribed medication for pain management. This powerful analgesic combines the opioid properties of hydrocodone with the pain-relieving and fever-reducing effects of acetaminophen. Healthcare providers often prescribe this medication for moderate to severe pain, particularly in postoperative patients, those with trauma, or individuals battling cancer.
The efficacy of this combination has been demonstrated in several randomized studies, showing significantly better pain control compared to placebo without a substantial increase in adverse effects. Additionally, this medication finds use as an antitussive agent, helping to suppress coughs in certain patients.
Mechanism of Action: How Hydrocodone and Acetaminophen Work Together
To understand the effectiveness of this medication, it’s crucial to examine how each component functions within the body:
Hydrocodone’s Role
Hydrocodone is a full opioid agonist that primarily interacts with mu-receptors and, to a lesser extent, delta receptors in the body. When these mu-opioid receptors are activated, they inhibit nociceptive pain reflexes, resulting in profound analgesia without affecting other sensory modalities like touch. Furthermore, activated opioid receptors inhibit the release of neurotransmitters, including substance P, which plays a role in pain perception.
After administration, hydrocodone reaches maximum serum concentrations within an hour and has an elimination half-life of 4 to 6 hours. It’s important to note that hydrocodone must be metabolized by the enzyme CYP2D6 to its active form, hydromorphone, to exert its full effects.
Acetaminophen’s Contribution
While the exact mechanism of acetaminophen’s analgesic action isn’t fully understood, it’s believed to work through COX inhibition and activation of descending serotonergic inhibitory pathways in the central nervous system. Its antipyretic (fever-reducing) effects occur via inhibition of the hypothalamic heat-regulating center.
Acetaminophen is readily absorbed from the gastrointestinal tract, with plasma protein binding of about 10 to 25%. Its plasma half-life typically ranges from 1 to 3 hours, though this may increase in cases of liver damage following an overdose. Approximately 85% of the drug is eliminated in the urine within 24 hours of administration.
Available Formulations and Dosage Strengths
Hydrocodone and acetaminophen combination is available in various formulations to suit different patient needs:
Oral Tablet Formulations
- Hydrocodone bitartrate 5 mg / acetaminophen 300 mg
- Hydrocodone bitartrate 5 mg / acetaminophen 325 mg
- Hydrocodone bitartrate 7.5 mg / acetaminophen 300 mg
- Hydrocodone bitartrate 7.5 mg / acetaminophen 325 mg
- Hydrocodone bitartrate 10 mg / acetaminophen 300 mg
- Hydrocodone bitartrate 10 mg / acetaminophen 325 mg
Oral Solution Formulation
- Hydrocodone bitartrate 7.5 mg / acetaminophen 325 mg per 15 mL
Proper Administration and Dosing Guidelines
Proper administration of hydrocodone and acetaminophen is crucial for effective pain management and minimizing the risk of adverse effects. Healthcare providers should consider the following guidelines:
General Dosing Principles
The golden rule in pain management with this medication is to use the lowest effective dose. Dosage should be individually titrated for each patient, taking into account:
- Severity of pain
- Patient’s response to the medication
- Prior analgesic experience
Oral Tablet Dosing
For initial oral tablet therapy using the 5 mg / 300 mg formulation:
- Usual adult dose: One or two tablets every four to six hours as needed for pain
- Maximum daily dosage: No more than eight tablets
Oral Solution Dosing
When using the oral solution (7.5 mg / 325 mg per 15 mL):
- Usual adult dose: One tablespoonful (15 mL) every 4 to 6 hours as needed for pain
- Maximum daily dosage: No more than six tablespoonfuls
Special Considerations in Dosing and Administration
When transitioning patients from other opioids to hydrocodone and acetaminophen therapy, healthcare providers should exercise caution:
- It’s recommended to underestimate the 24-hour dose of hydrocodone bitartrate and acetaminophen to manage potential adverse reactions and reduce the risk of overdose.
- The relative bioavailability information for conversion from extended-release hydrocodone to hydrocodone and acetaminophen therapy is unknown.
- Close monitoring for signs of excessive sedation and respiratory depression is essential during the transition period.
- Dose titration should be performed on an individual basis to achieve optimal pain control with minimal side effects.
Monitoring and Safety Considerations
Ensuring patient safety while using hydrocodone and acetaminophen combination requires vigilant monitoring and adherence to safety guidelines:
Liver Function Monitoring
Given the presence of acetaminophen in this combination, regular monitoring of liver function is crucial, especially in patients with pre-existing liver conditions or those on long-term therapy. Healthcare providers should educate patients about the signs of liver toxicity and the importance of adhering to prescribed dosages.
Respiratory Depression Risk
As with all opioid medications, there’s a risk of respiratory depression with hydrocodone. Patients should be monitored closely, particularly during the initiation of therapy or when dosages are increased. This risk is heightened in elderly patients, those with respiratory conditions, or individuals taking other central nervous system depressants.
Addiction and Dependence
Given the opioid component, there’s a potential for addiction and physical dependence. Healthcare providers should assess patients’ risk factors for opioid abuse before prescribing and regularly during treatment. Implementing strategies to minimize the risk of misuse and diversion is essential.
Managing Adverse Effects and Complications
While hydrocodone and acetaminophen combination is generally well-tolerated when used as directed, patients may experience various side effects:
Common Side Effects
- Constipation
- Nausea and vomiting
- Dizziness
- Drowsiness
- Itching
Healthcare providers should proactively manage these side effects to improve patient compliance and quality of life. For instance, prescribing a stool softener or laxative can help manage opioid-induced constipation.
Serious Adverse Effects
More serious complications that require immediate medical attention include:
- Signs of respiratory depression
- Severe allergic reactions
- Symptoms of liver toxicity (e.g., yellowing of skin or eyes, dark urine, persistent nausea)
- Signs of serotonin syndrome when used with other serotonergic medications
Educating patients about these potential complications and when to seek medical help is crucial for safe medication use.
Interprofessional Team Strategies for Optimal Outcomes
Effective pain management with hydrocodone and acetaminophen requires a collaborative approach involving various healthcare professionals:
Role of Prescribers
Physicians and advanced practice providers play a critical role in:
- Conducting thorough patient assessments to determine the appropriateness of therapy
- Prescribing the medication at the lowest effective dose
- Regularly reassessing the need for continued therapy
- Monitoring for signs of misuse or addiction
Pharmacist Involvement
Pharmacists contribute to safe and effective use by:
- Reviewing prescriptions for appropriateness and potential drug interactions
- Providing patient education on proper use, storage, and disposal of the medication
- Monitoring for signs of overuse or early refill requests
Nursing Support
Nurses play a vital role in:
- Administering the medication in inpatient settings
- Monitoring patients for efficacy and adverse effects
- Providing ongoing patient education and support
Pain Management Specialists
In complex cases, involving pain management specialists can help:
- Optimize pain control strategies
- Implement multimodal approaches to reduce opioid requirements
- Manage challenging cases of chronic pain
By fostering open communication and collaboration among these healthcare professionals, the interprofessional team can ensure optimal outcomes for patients using hydrocodone and acetaminophen combination therapy.
Patient Education: Empowering Safe and Effective Use
Educating patients is a crucial component of safe and effective hydrocodone and acetaminophen therapy. Healthcare providers should focus on the following key areas:
Proper Use and Administration
Patients should understand:
- The importance of taking the medication exactly as prescribed
- How to properly measure liquid formulations
- The dangers of crushing or chewing extended-release formulations, if applicable
- The need to avoid alcohol while taking this medication
Recognizing and Reporting Side Effects
Educate patients on:
- Common side effects and how to manage them
- Signs of serious adverse effects that require immediate medical attention
- The importance of reporting any unusual symptoms to their healthcare provider
Safe Storage and Disposal
Instruct patients to:
- Store the medication in a secure location, out of reach of children and pets
- Never share their medication with others
- Properly dispose of unused medication through drug take-back programs or as advised by their pharmacist
Avoiding Potential Drug Interactions
Encourage patients to:
- Maintain an up-to-date list of all medications, including over-the-counter drugs and supplements
- Consult their healthcare provider or pharmacist before starting any new medications
- Be aware of the risks associated with combining this medication with other central nervous system depressants
By empowering patients with this knowledge, healthcare providers can enhance medication adherence, improve safety, and ultimately achieve better pain management outcomes.
Hydrocodone and Acetaminophen – StatPearls
Continuing Education Activity
Hydrocodone is one of the most common pain medications prescribed by clinicians and one of the most abused by patients. It is a relatively potent drug for moderate-to-severe pain control in postoperative patients, patients with trauma, or patients with cancer. The combination of hydrocodone with acetaminophen is much more efficacious in several randomized studies without any significant changes in adverse effects. Moreover, hydrocodone/acetaminophen has common use as an antitussive agent. This activity outlines the indications, mechanism of action, methods of administration, significant adverse effects, contraindications, monitoring, and toxicity of hydrocodone/acetaminophen so that providers can direct patient therapy to optimal outcomes.
Objectives:
Identify the mechanism of action of hydrocodone/acetaminophen.
Outline the approved uses for initiating hydrocodone/acetaminophen therapy.
Summarize the adverse event profile and contraindications to using hydrocodone/acetaminophen.
Explain interprofessional team strategies for improving care coordination and communication to advance hydrocodone/acetaminophen therapy, improve outcomes, and minimize adverse events and misuse, especially in light of the ongoing opioid crisis.
Access free multiple choice questions on this topic.
Indications
Hydrocodone is one of the most common pain medications prescribed by clinicians and one of the most abused by patients. It is a relatively potent drug for moderate-to-severe pain control in postoperative patients, patients with trauma, and patients with cancer. The combination of hydrocodone with acetaminophen is much more efficacious than placebo in several randomized studies without any significant changes in adverse effects.[1] Moreover, hydrocodone/acetaminophen has common use as an antitussive agent.[2]
Mechanism of Action
Hydrocodone is a full opioid agonist that interacts with the mu-receptors and, to a lesser extent, with delta receptors in the body. [3] Activated mu-opioid receptors lead to inhibition of nociceptive pain reflexes and induce profound analgesia without affecting other sensory modalities such as touch. Additionally, activated opioid receptors inhibit neurotransmitter release, including substance P.[3] Hydrocodone reaches maximum serum concentrations within 1 hour with an elimination half-life of 4 to 6 hours.[4] Hydrocodone has to be metabolized by CYP2D6 to its active form, hydromorphone.[3]
Acetaminophen’s mechanism of action of analgesia is not fully understood. The hypothesis has been that it results from COX inhibition and activation of descending serotonergic inhibitory pathways in the CNS. Antipyretic effects occur via inhibition of the hypothalamic heat-regulating center. Acetaminophen is readily absorbed from the gastrointestinal tract. Plasma protein binding of acetaminophen is about 10 to 25%. The plasma half-life ranges from 1 to 3 hours; however, it may increase due to liver damage following overdose. Approximately 85% of the drug is eliminated in the urine within 24 hours of administration.[5]
Administration
Hydrocodone and acetaminophen combination is available as oral tablet and oral solution formulation.
Hydrocodone bitartrate 5 mg / acetaminophen 300 mg
Hydrocodone bitartrate 5 mg / acetaminophen 325 mg
Hydrocodone bitartrate 7.5 mg / acetaminophen 300 mg
Hydrocodone bitartrate 7.5 mg / acetaminophen 325 mg
Hydrocodone bitartrate 10 mg / acetaminophen 300 mg
Hydrocodone bitartrate 10 mg / acetaminophen 325 mg
Hydrocodone bitartrate 7.5 mg / acetaminophen 325 mg per 15 mL oral solution
Dosing Regimen for Pain Management
The lowest dose necessary for adequate analgesia is recommended and should be titrated individually for each patient taking into account the severity of pain, response, and prior analgesic experience.
For initial oral tablets therapy, the usual adult dose of hydrocodone and acetaminophen ( 5 mg / 300 mg) is one or two tablets every four to six hours as needed for pain. The total daily dosage should not be more than eight tablets.
For initial oral solution therapy, the usual adult dose of solution ( 7.5mg / 325mg per 15 mL) is one tablespoonful (15 mL) every 4 to 6 hours as needed for pain. The total daily dosage for adults should not be more than six tablespoonfuls.
For the conversion from other opioids to hydrocodone and acetaminophen therapy, it is recommended to underestimate the dose of hydrocodone bitartrate and acetaminophen on 24 hours basis for managing an adverse reaction due to the risk of overdose. The relative bioavailability information is unknown for conversion from extended-release hydrocodone to hydrocodone and acetaminophen therapy. So close monitoring for signs of excessive sedation and respiratory depression is recommended. The dose should be titrated on an individual basis. Continuous reevaluation of the dose of hydrocodone and acetaminophen is needed to maintain adequate pain control, minimize adverse effects, and monitor the development of addiction, abuse, or misuse.
For patients who may have a physical dependence on opioids, abrupt discontinuation of hydrocodone and acetaminophen therapy may result in severe withdrawal symptoms, uncontrolled pain, and suicidal tendency.
Specific Patients Population
Patient with Hepatic Impairment: There is no dose adjustment guidance in the manufacturer label for patients with hepatic impairment. However, initiating therapy with the lowest dose with continuous monitoring is recommended in these patients.
Patient with Renal Impairment: There is no dose adjustment guidance in the manufacturer label for patients with renal impairment. However, 26% of hydrocodone and 85% of acetaminophen are eliminated in the urine, so the drug should be used with caution.
Pregnant Women: It is considered as pregnancy category C medicine. There is a US box warning related to pregnancy. During pregnancy, prolonged use of hydrocodone and acetaminophen can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized early and treated accordingly.
Breastfeeding Women: Hydrocodone and Acetaminophen are present in breast milk. The decision to continue or discontinue breastfeeding during therapy should be based on the risk of infant exposure versus the benefits of breastfeeding and treatment to the mother.[6][7]
Pediatric Patients: The dose of hydrocodone for pediatric patients is titrated based on desired analgesic effect. While considering acetaminophen dose, it is recommended to consider the maximum daily dose of acetaminophen from all other sources like OTC, other prescription, or combination products. The maximum daily dose should not exceed 2000 mg for acetaminophen to minimize hepatotoxicity maximum. Based on the information provided in the hydrocodone and acetaminophen oral solution label, dosing should be calculated as 0.27 mL/kg child weight (equivalent to 0.135 mg/kg hydrocodone and 5.85 mg/kg dose of acetaminophen) whenever possible.
Geriatric Patients: For safety and efficacy, it is recommended to start the initial dose at the lower end of the dosing range in geriatric patients and monitor patients closely.
Adverse Effects
Opioid-induced constipation, dizziness, nausea, vomiting, drowsiness, and respiratory depression are common adverse reactions of hydrocodone-acetaminophen medication. There have been reports of progressive sensorineural hearing loss with chronic hydrocodone/acetaminophen use that is not responsive to high-dose steroids but responsive to cochlear implantation.[2]
As with all opioids, tolerance leading to ever-increasing doses of opioids to maintain the same level of pain control and physical dependence is the most common side effect. Moreover, acute and chronic opioid administration can inhibit antibody and cellular immune responses, natural killer cell activity, cytokine expression, and phagocytic activity. As a result, there are implications of opioids, pointing to an increased incidence of infections in subjects with heroin use disorder.
Opioid users also suffer from endocrine changes in the body, including but not limited to sexual dysfunction, depression, and decreased energy levels, resulting from hypogonadotropic hypogonadism. Also, opioid-induced hyperalgesia is a recently recognized phenomenon after patients experienced increasing pain despite increasing doses of opioids.[2]
Other Adverse Reactions
Central Nervous System: Lethargy, mental clouding, impairment of the physical and mental performance, fear, anxiety, dysphoria, mood changes, dependence
Genitourinary System: Ureteral spasm, urinary retention, spasm of vesical sphincters reported with opiates
Dermatological: Pruritus and skin rash
Contraindications
Contraindications to hydrocodone/acetaminophen include patients with severe respiratory depression, acute or significant bronchial asthma, gastrointestinal obstruction, and anaphylactic reactions due to components of the formula.
As per the manufacturer’s label, several drugs interact with hydrocodone/acetaminophen and caution should be used when they are coadministered.[8][9]
CYP3A4 and CYP2D6 Inhibitors: The coadministration of hydrocodone and acetaminophen with CYP3A4 inhibitors (erythromycin, ketoconazole, and ritonavir) may lead to an increase in the plasma concentration of the hydrocodone and this may result in increased or prolonged opioid effects. These effects may be more pronounced when CYP3A4 and CYP2D6 inhibitors are coadministered with hydrocodone and acetaminophen.
CYP3A4 Inducers: The coadministration of hydrocodone and acetaminophen with CYP3A4 inducers (rifampin, carbamazepine, and phenytoin) may lead to a decrease in the plasma concentration of hydrocodone, and this may result in decreased efficacy.
Benzodiazepines or Other CNS Depressants: The coadministration of hydrocodone and acetaminophen with benzodiazepines or other CNS depressants, due to its additive pharmacologic effect, may lead to an increase in the risk of hypotension, respiratory depression, severe sedation, coma, and death.
Serotonergic Drugs: The coadministration of hydrocodone and acetaminophen with other drugs that affect the serotonergic neurotransmitter system (selective serotonin reuptake inhibitors, serotonin, and norepinephrine reuptake inhibitors, tricyclic antidepressants, triptans, 5-HT3 receptor antagonists) or with drugs that affect the serotonin neurotransmitter system (mirtazapine, trazodone, tramadol cyclobenzaprine, metaxalone, monoamine oxidase inhibitors) may result in serotonin syndrome.
Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics: The coadministration of hydrocodone and acetaminophen with other opioid analgesics (butorphanol, nalbuphine, pentazocine) may lead to reducing the analgesic effect of opioids and/or precipitate withdrawal symptoms.
Muscle Relaxants: The coadministration of hydrocodone and acetaminophen with muscle relaxants may enhance the neuromuscular blocking action and may induce a higher degree of respiratory depression.
Diuretics: The coadministration of hydrocodone and acetaminophen with other diuretics may reduce the efficacy of diuretics due to the induction of antidiuretic hormone.
Anticholinergic Drugs: The coadministration of hydrocodone and acetaminophen with anticholinergic drugs may increase the risk of urinary retention and/or severe constipation.
Monitoring
Pain relief and adverse events should undergo frequent assessments. The dosing should start low and slow and titrated up as necessary to obtain adequate analgesia while having minimal side effects.
Hydrocodone is a DEA Schedule II controlled substance and since it has a potential for abuse, misuse, and use disorder. Consequently, it is vital to monitor patients for addiction, abuse, and misuse signs. In addition, patients with a prior history of drug addiction or mental illness have a higher risk of addiction.
For toxicity monitoring, obtain serial liver function tests in patients with severe hepatic disease. Also, monitor serial renal function in elderly patients and patients with severe renal disease.
The clinicians should monitor the following physical findings for the signs of toxicity.
Signs of confusion and over-sedation in the elderly
Addiction, abuse, or misuse behaviors and conditions during treatment
Signs of respiratory depression, especially within 24 to 72 hours of treatment initiation and after dose increases
Signs and symptoms of respiratory depression and sedation in patients susceptible to the intracranial effects of carbon dioxide retention
Severe hypotension at the start of treatment and dose modification
In patients with a history of seizure disorders, monitor for worsened seizure control
Toxicity
Acetaminophen has been associated with fatal hepatic necrosis if taken at doses more than 4 g per day, especially with the ingestion of another acetaminophen-containing product. Furthermore, large doses may cause difficulty with breathing. In overdose, activated charcoal should be the first attempted intervention before N-acetylcysteine (NAC). For patients presenting for 4 hours or later, the serum acetaminophen level should be obtained promptly.
Hydrocodone intake may lead to life-threatening respiratory depression, especially if taken together with benzodiazepines or other CNS depressants. In case of overdose, the first step is to protect the airways and place the patient on invasive ventilation assistance, if needed. The opioid antagonists, nalmefene or naloxone, are specific antidotes for respiratory depression. Opioid antagonists should be avoided in the absence of clinically significant respiratory or circulatory depression. In addition, there is a high risk of precipitating acute opioid withdrawal in an individual who is physically dependent on opioids.
Enhancing Healthcare Team Outcomes
It is not surprising that, without proper barriers and monitoring for the detrimental effects of hydrocodone and acetaminophen intoxication, the morbidity and mortality of using opioid analgesia can be quite substantial. The drug information sheet from the manufacturer emphasizes in bold letters the importance of warning patients of abuse, misuse, and addiction of hydrocodone and acetaminophen, which can lead to overdose and death. Multiple efforts point toward reducing prescription abuse and misuse.
The mitigation of opioid overdose and misuse risk starts from the system-level intervention by clinicians and nurses prescribing narcotics. In addition, the Prescription Drug Monitoring Program and Medicaid managed care lock-in program require that patients receive all scripts from a single prescriber. Although over 55% dropped from the program, the proportion of stable patients, i.e., patients exclusively filled from one prescriber, increased from 31% to 78% at 36 months.[10] [Level 4]
Pharmacists should use formulary management tools to address both opioid overprescribing and overdose. One of them is a prior authorization requirement placed by the insurance companies to verify that the medication is necessary. Cochran et al. conducted a retrospective cohort study evaluating the effects of prior authorization on the rate of abuse and overdose of patients enrolled in the Pennsylvania Medicaid program from 2010 to 2012. The study demonstrated that plans with prior authorization requirements had lower rates of use disorder and overdose.[11] [Level 4]
All in all, there is a battle to reduce the opioid prescription crisis, and still, rates of overdose continue. Numerous interventions show some promise in mitigating this problem, and it truly takes an interprofessional team, including clinicians, mid-level practitioners, nurses, and pharmacists, to achieve this goal. [Level 5]
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References
- 1.
Vardy J, Agar M. Nonopioid drugs in the treatment of cancer pain. J Clin Oncol. 2014 Jun 01;32(16):1677-90. [PubMed: 24799483]
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Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, Glaser SE, Vallejo R. Opioid complications and side effects. Pain Physician. 2008 Mar;11(2 Suppl):S105-20. [PubMed: 18443635]
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Sarhill N, Walsh D, Nelson KA. Hydromorphone: pharmacology and clinical applications in cancer patients. Support Care Cancer. 2001 Mar;9(2):84-96. [PubMed: 11305075]
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Smith HS. The metabolism of opioid agents and the clinical impact of their active metabolites. Clin J Pain. 2011 Nov-Dec;27(9):824-38. [PubMed: 21677572]
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Jóźwiak-Bebenista M, Nowak JZ. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. 2014 Jan-Feb;71(1):11-23. [PubMed: 24779190]
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Drugs and Lactation Database (LactMed®) [Internet]. National Institute of Child Health and Human Development; Bethesda (MD): Sep 19, 2022. Hydrocodone. [PubMed: 30000284]
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Drugs and Lactation Database (LactMed®) [Internet]. National Institute of Child Health and Human Development; Bethesda (MD): Mar 21, 2022. Acetaminophen. [PubMed: 30000253]
- 8.
Monte AA, Heard KJ, Campbell J, Hamamura D, Weinshilboum RM, Vasiliou V. The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness. Acad Emerg Med. 2014 Aug;21(8):879-85. [PMC free article: PMC4150819] [PubMed: 25156930]
- 9.
Lee D, Stout P, Egdorf D. Houston Cocktail: Driving under influence of hydrocodone, alprazolam, and carisoprodol. Forensic Sci Int. 2021 Apr 28;323:110819. [PubMed: 33964487]
- 10.
Dreyer TR, Michalski T, Williams BC. Patient Outcomes in a Medicaid Managed Care Lock-In Program. J Manag Care Spec Pharm. 2015 Nov;21(11):1006-12. [PubMed: 26521112]
- 11.
Cochran G, Gordon AJ, Gellad WF, Chang CH, Lo-Ciganic WH, Lobo C, Cole E, Frazier W, Zheng P, Kelley D, Donohue JM. Medicaid prior authorization and opioid medication abuse and overdose. Am J Manag Care. 2017 May 01;23(5):e164-e171. [PMC free article: PMC6719534] [PubMed: 28810127]
Disclosure: Manuchehr Habibi declares no relevant financial relationships with ineligible companies.
Disclosure: Peggy Kim declares no relevant financial relationships with ineligible companies.
Hydrocodone and Acetaminophen – StatPearls
Continuing Education Activity
Hydrocodone is one of the most common pain medications prescribed by clinicians and one of the most abused by patients. It is a relatively potent drug for moderate-to-severe pain control in postoperative patients, patients with trauma, or patients with cancer. The combination of hydrocodone with acetaminophen is much more efficacious in several randomized studies without any significant changes in adverse effects. Moreover, hydrocodone/acetaminophen has common use as an antitussive agent. This activity outlines the indications, mechanism of action, methods of administration, significant adverse effects, contraindications, monitoring, and toxicity of hydrocodone/acetaminophen so that providers can direct patient therapy to optimal outcomes.
Objectives:
Identify the mechanism of action of hydrocodone/acetaminophen.
Outline the approved uses for initiating hydrocodone/acetaminophen therapy.
Summarize the adverse event profile and contraindications to using hydrocodone/acetaminophen.
Explain interprofessional team strategies for improving care coordination and communication to advance hydrocodone/acetaminophen therapy, improve outcomes, and minimize adverse events and misuse, especially in light of the ongoing opioid crisis.
Access free multiple choice questions on this topic.
Indications
Hydrocodone is one of the most common pain medications prescribed by clinicians and one of the most abused by patients. It is a relatively potent drug for moderate-to-severe pain control in postoperative patients, patients with trauma, and patients with cancer. The combination of hydrocodone with acetaminophen is much more efficacious than placebo in several randomized studies without any significant changes in adverse effects. [1] Moreover, hydrocodone/acetaminophen has common use as an antitussive agent.[2]
Mechanism of Action
Hydrocodone is a full opioid agonist that interacts with the mu-receptors and, to a lesser extent, with delta receptors in the body.[3] Activated mu-opioid receptors lead to inhibition of nociceptive pain reflexes and induce profound analgesia without affecting other sensory modalities such as touch. Additionally, activated opioid receptors inhibit neurotransmitter release, including substance P.[3] Hydrocodone reaches maximum serum concentrations within 1 hour with an elimination half-life of 4 to 6 hours.[4] Hydrocodone has to be metabolized by CYP2D6 to its active form, hydromorphone.[3]
Acetaminophen’s mechanism of action of analgesia is not fully understood. The hypothesis has been that it results from COX inhibition and activation of descending serotonergic inhibitory pathways in the CNS. Antipyretic effects occur via inhibition of the hypothalamic heat-regulating center. Acetaminophen is readily absorbed from the gastrointestinal tract. Plasma protein binding of acetaminophen is about 10 to 25%. The plasma half-life ranges from 1 to 3 hours; however, it may increase due to liver damage following overdose. Approximately 85% of the drug is eliminated in the urine within 24 hours of administration.[5]
Administration
Hydrocodone and acetaminophen combination is available as oral tablet and oral solution formulation.
Hydrocodone bitartrate 5 mg / acetaminophen 300 mg
Hydrocodone bitartrate 5 mg / acetaminophen 325 mg
Hydrocodone bitartrate 7.5 mg / acetaminophen 300 mg
Hydrocodone bitartrate 7.5 mg / acetaminophen 325 mg
Hydrocodone bitartrate 10 mg / acetaminophen 300 mg
Hydrocodone bitartrate 10 mg / acetaminophen 325 mg
Hydrocodone bitartrate 7.5 mg / acetaminophen 325 mg per 15 mL oral solution
Dosing Regimen for Pain Management
The lowest dose necessary for adequate analgesia is recommended and should be titrated individually for each patient taking into account the severity of pain, response, and prior analgesic experience.
For initial oral tablets therapy, the usual adult dose of hydrocodone and acetaminophen ( 5 mg / 300 mg) is one or two tablets every four to six hours as needed for pain. The total daily dosage should not be more than eight tablets.
For initial oral solution therapy, the usual adult dose of solution ( 7.5mg / 325mg per 15 mL) is one tablespoonful (15 mL) every 4 to 6 hours as needed for pain. The total daily dosage for adults should not be more than six tablespoonfuls.
For the conversion from other opioids to hydrocodone and acetaminophen therapy, it is recommended to underestimate the dose of hydrocodone bitartrate and acetaminophen on 24 hours basis for managing an adverse reaction due to the risk of overdose. The relative bioavailability information is unknown for conversion from extended-release hydrocodone to hydrocodone and acetaminophen therapy. So close monitoring for signs of excessive sedation and respiratory depression is recommended. The dose should be titrated on an individual basis. Continuous reevaluation of the dose of hydrocodone and acetaminophen is needed to maintain adequate pain control, minimize adverse effects, and monitor the development of addiction, abuse, or misuse.
For patients who may have a physical dependence on opioids, abrupt discontinuation of hydrocodone and acetaminophen therapy may result in severe withdrawal symptoms, uncontrolled pain, and suicidal tendency.
Specific Patients Population
Patient with Hepatic Impairment: There is no dose adjustment guidance in the manufacturer label for patients with hepatic impairment. However, initiating therapy with the lowest dose with continuous monitoring is recommended in these patients.
Patient with Renal Impairment: There is no dose adjustment guidance in the manufacturer label for patients with renal impairment. However, 26% of hydrocodone and 85% of acetaminophen are eliminated in the urine, so the drug should be used with caution.
Pregnant Women: It is considered as pregnancy category C medicine. There is a US box warning related to pregnancy. During pregnancy, prolonged use of hydrocodone and acetaminophen can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized early and treated accordingly.
Breastfeeding Women: Hydrocodone and Acetaminophen are present in breast milk. The decision to continue or discontinue breastfeeding during therapy should be based on the risk of infant exposure versus the benefits of breastfeeding and treatment to the mother.[6][7]
Pediatric Patients: The dose of hydrocodone for pediatric patients is titrated based on desired analgesic effect. While considering acetaminophen dose, it is recommended to consider the maximum daily dose of acetaminophen from all other sources like OTC, other prescription, or combination products. The maximum daily dose should not exceed 2000 mg for acetaminophen to minimize hepatotoxicity maximum. Based on the information provided in the hydrocodone and acetaminophen oral solution label, dosing should be calculated as 0.27 mL/kg child weight (equivalent to 0.135 mg/kg hydrocodone and 5.85 mg/kg dose of acetaminophen) whenever possible.
Geriatric Patients: For safety and efficacy, it is recommended to start the initial dose at the lower end of the dosing range in geriatric patients and monitor patients closely.
Adverse Effects
Opioid-induced constipation, dizziness, nausea, vomiting, drowsiness, and respiratory depression are common adverse reactions of hydrocodone-acetaminophen medication. There have been reports of progressive sensorineural hearing loss with chronic hydrocodone/acetaminophen use that is not responsive to high-dose steroids but responsive to cochlear implantation.[2]
As with all opioids, tolerance leading to ever-increasing doses of opioids to maintain the same level of pain control and physical dependence is the most common side effect. Moreover, acute and chronic opioid administration can inhibit antibody and cellular immune responses, natural killer cell activity, cytokine expression, and phagocytic activity. As a result, there are implications of opioids, pointing to an increased incidence of infections in subjects with heroin use disorder.
Opioid users also suffer from endocrine changes in the body, including but not limited to sexual dysfunction, depression, and decreased energy levels, resulting from hypogonadotropic hypogonadism. Also, opioid-induced hyperalgesia is a recently recognized phenomenon after patients experienced increasing pain despite increasing doses of opioids.[2]
Other Adverse Reactions
Central Nervous System: Lethargy, mental clouding, impairment of the physical and mental performance, fear, anxiety, dysphoria, mood changes, dependence
Genitourinary System: Ureteral spasm, urinary retention, spasm of vesical sphincters reported with opiates
Dermatological: Pruritus and skin rash
Contraindications
Contraindications to hydrocodone/acetaminophen include patients with severe respiratory depression, acute or significant bronchial asthma, gastrointestinal obstruction, and anaphylactic reactions due to components of the formula.
As per the manufacturer’s label, several drugs interact with hydrocodone/acetaminophen and caution should be used when they are coadministered.[8][9]
CYP3A4 and CYP2D6 Inhibitors: The coadministration of hydrocodone and acetaminophen with CYP3A4 inhibitors (erythromycin, ketoconazole, and ritonavir) may lead to an increase in the plasma concentration of the hydrocodone and this may result in increased or prolonged opioid effects. These effects may be more pronounced when CYP3A4 and CYP2D6 inhibitors are coadministered with hydrocodone and acetaminophen.
CYP3A4 Inducers: The coadministration of hydrocodone and acetaminophen with CYP3A4 inducers (rifampin, carbamazepine, and phenytoin) may lead to a decrease in the plasma concentration of hydrocodone, and this may result in decreased efficacy.
Benzodiazepines or Other CNS Depressants: The coadministration of hydrocodone and acetaminophen with benzodiazepines or other CNS depressants, due to its additive pharmacologic effect, may lead to an increase in the risk of hypotension, respiratory depression, severe sedation, coma, and death.
Serotonergic Drugs: The coadministration of hydrocodone and acetaminophen with other drugs that affect the serotonergic neurotransmitter system (selective serotonin reuptake inhibitors, serotonin, and norepinephrine reuptake inhibitors, tricyclic antidepressants, triptans, 5-HT3 receptor antagonists) or with drugs that affect the serotonin neurotransmitter system (mirtazapine, trazodone, tramadol cyclobenzaprine, metaxalone, monoamine oxidase inhibitors) may result in serotonin syndrome.
Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics: The coadministration of hydrocodone and acetaminophen with other opioid analgesics (butorphanol, nalbuphine, pentazocine) may lead to reducing the analgesic effect of opioids and/or precipitate withdrawal symptoms.
Muscle Relaxants: The coadministration of hydrocodone and acetaminophen with muscle relaxants may enhance the neuromuscular blocking action and may induce a higher degree of respiratory depression.
Diuretics: The coadministration of hydrocodone and acetaminophen with other diuretics may reduce the efficacy of diuretics due to the induction of antidiuretic hormone.
Anticholinergic Drugs: The coadministration of hydrocodone and acetaminophen with anticholinergic drugs may increase the risk of urinary retention and/or severe constipation.
Monitoring
Pain relief and adverse events should undergo frequent assessments. The dosing should start low and slow and titrated up as necessary to obtain adequate analgesia while having minimal side effects.
Hydrocodone is a DEA Schedule II controlled substance and since it has a potential for abuse, misuse, and use disorder. Consequently, it is vital to monitor patients for addiction, abuse, and misuse signs. In addition, patients with a prior history of drug addiction or mental illness have a higher risk of addiction.
For toxicity monitoring, obtain serial liver function tests in patients with severe hepatic disease. Also, monitor serial renal function in elderly patients and patients with severe renal disease.
The clinicians should monitor the following physical findings for the signs of toxicity.
Signs of confusion and over-sedation in the elderly
Addiction, abuse, or misuse behaviors and conditions during treatment
Signs of respiratory depression, especially within 24 to 72 hours of treatment initiation and after dose increases
Signs and symptoms of respiratory depression and sedation in patients susceptible to the intracranial effects of carbon dioxide retention
Severe hypotension at the start of treatment and dose modification
In patients with a history of seizure disorders, monitor for worsened seizure control
Toxicity
Acetaminophen has been associated with fatal hepatic necrosis if taken at doses more than 4 g per day, especially with the ingestion of another acetaminophen-containing product. Furthermore, large doses may cause difficulty with breathing. In overdose, activated charcoal should be the first attempted intervention before N-acetylcysteine (NAC). For patients presenting for 4 hours or later, the serum acetaminophen level should be obtained promptly.
Hydrocodone intake may lead to life-threatening respiratory depression, especially if taken together with benzodiazepines or other CNS depressants. In case of overdose, the first step is to protect the airways and place the patient on invasive ventilation assistance, if needed. The opioid antagonists, nalmefene or naloxone, are specific antidotes for respiratory depression. Opioid antagonists should be avoided in the absence of clinically significant respiratory or circulatory depression. In addition, there is a high risk of precipitating acute opioid withdrawal in an individual who is physically dependent on opioids.
Enhancing Healthcare Team Outcomes
It is not surprising that, without proper barriers and monitoring for the detrimental effects of hydrocodone and acetaminophen intoxication, the morbidity and mortality of using opioid analgesia can be quite substantial. The drug information sheet from the manufacturer emphasizes in bold letters the importance of warning patients of abuse, misuse, and addiction of hydrocodone and acetaminophen, which can lead to overdose and death. Multiple efforts point toward reducing prescription abuse and misuse.
The mitigation of opioid overdose and misuse risk starts from the system-level intervention by clinicians and nurses prescribing narcotics. In addition, the Prescription Drug Monitoring Program and Medicaid managed care lock-in program require that patients receive all scripts from a single prescriber. Although over 55% dropped from the program, the proportion of stable patients, i.e., patients exclusively filled from one prescriber, increased from 31% to 78% at 36 months.[10] [Level 4]
Pharmacists should use formulary management tools to address both opioid overprescribing and overdose. One of them is a prior authorization requirement placed by the insurance companies to verify that the medication is necessary. Cochran et al. conducted a retrospective cohort study evaluating the effects of prior authorization on the rate of abuse and overdose of patients enrolled in the Pennsylvania Medicaid program from 2010 to 2012. The study demonstrated that plans with prior authorization requirements had lower rates of use disorder and overdose.[11] [Level 4]
All in all, there is a battle to reduce the opioid prescription crisis, and still, rates of overdose continue. Numerous interventions show some promise in mitigating this problem, and it truly takes an interprofessional team, including clinicians, mid-level practitioners, nurses, and pharmacists, to achieve this goal. [Level 5]
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References
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Vardy J, Agar M. Nonopioid drugs in the treatment of cancer pain. J Clin Oncol. 2014 Jun 01;32(16):1677-90. [PubMed: 24799483]
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Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, Glaser SE, Vallejo R. Opioid complications and side effects. Pain Physician. 2008 Mar;11(2 Suppl):S105-20. [PubMed: 18443635]
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Sarhill N, Walsh D, Nelson KA. Hydromorphone: pharmacology and clinical applications in cancer patients. Support Care Cancer. 2001 Mar;9(2):84-96. [PubMed: 11305075]
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Smith HS. The metabolism of opioid agents and the clinical impact of their active metabolites. Clin J Pain. 2011 Nov-Dec;27(9):824-38. [PubMed: 21677572]
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Jóźwiak-Bebenista M, Nowak JZ. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. 2014 Jan-Feb;71(1):11-23. [PubMed: 24779190]
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Drugs and Lactation Database (LactMed®) [Internet]. National Institute of Child Health and Human Development; Bethesda (MD): Sep 19, 2022. Hydrocodone. [PubMed: 30000284]
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Drugs and Lactation Database (LactMed®) [Internet]. National Institute of Child Health and Human Development; Bethesda (MD): Mar 21, 2022. Acetaminophen. [PubMed: 30000253]
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Monte AA, Heard KJ, Campbell J, Hamamura D, Weinshilboum RM, Vasiliou V. The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness. Acad Emerg Med. 2014 Aug;21(8):879-85. [PMC free article: PMC4150819] [PubMed: 25156930]
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Lee D, Stout P, Egdorf D. Houston Cocktail: Driving under influence of hydrocodone, alprazolam, and carisoprodol. Forensic Sci Int. 2021 Apr 28;323:110819. [PubMed: 33964487]
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Dreyer TR, Michalski T, Williams BC. Patient Outcomes in a Medicaid Managed Care Lock-In Program. J Manag Care Spec Pharm. 2015 Nov;21(11):1006-12. [PubMed: 26521112]
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Cochran G, Gordon AJ, Gellad WF, Chang CH, Lo-Ciganic WH, Lobo C, Cole E, Frazier W, Zheng P, Kelley D, Donohue JM. Medicaid prior authorization and opioid medication abuse and overdose. Am J Manag Care. 2017 May 01;23(5):e164-e171. [PMC free article: PMC6719534] [PubMed: 28810127]
Disclosure: Manuchehr Habibi declares no relevant financial relationships with ineligible companies.
Disclosure: Peggy Kim declares no relevant financial relationships with ineligible companies.
Norco 5/325 (Hydrocodone Bitartrate & Acetaminophen): Uses, Dosage, Side Effects, Interactions, Warning
Product description
What is Norco 5/325 and how is it used?
Norco 5/325 (hydrocodone acetaminophen and bitartrate) is an opioid analgesic and antitussive (cough suppressant) combined with an antipyretic and analgesic and is used to treat moderate to fairly severe pain. Norco 5/325 is available as a generic .
What are the side effects of Norco 5/325?
Common side effects of Norco 5/325 include:
- lightheadedness,
- nausea,
- vomiting,
- constipation,
- upset stomach,
- headache dizziness or drowsiness,
- restlessness,
- Headache,
- mood changes,
- blurred vision,
- ringing in the ears, or
- dry mouth.
DESCRIPTION
NORCO (hydrocodone bitartrate and acetaminophen) is supplied as tablets for oral use.
Hydrocodone bitartrate is an opioid analgesic and antitussive and occurs as fine white crystals or crystalline powder. It is affected by light. The chemical name is 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5). It has the following structural formula:
Acetaminophen, a 4-hydroxyacetanide, slightly bitter, white, odorless crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. Has the following structural formula:
Oral NORCO is available in the following dosages:
Hydrocodone
Acetaminophen Bitartrate
NORCO 7.5 / 325 7.5 mg 325 mg
NORCO 10/325 10 mg 325 mg
In addition, each tablet contains the following inactive ingredients: croscarmellose sodium, crospovidone, magnesium stearate, microcrystalline cellulose, povidone, pregelatinized starch and stearic acid; 7.5mg/325mg tablets include FD&C Yellow #6 Aluminum Lake, 10mg/325mg tablets include D&C Yellow #10 Aluminum Lake. Meets USP 1 dissolution test.
Indications and dosage
INDICATIONS
NORCO is indicated for the relief of moderate to moderately severe pain.
DOSAGE AND ADMINISTRATION
Dosage should be adjusted according to the degree of pain and the response of the patient. However, it should be borne in mind that tolerance to hydrocodone may develop with continued use and that the frequency of adverse effects is dose dependent.
The usual adult dose is one tablet every four to six hours as needed for pain relief. The total daily dosage should not exceed 6 tablets.
HOW SUPPLIED
NORCO 7.5 / 325 Available as capsules of light orange tablets, split in half on one side and embossed with “NORCO 729” on the other side. Each tablet contains 7.5 mg hydrocodone bitartrate and 325 mg acetaminophen. They are supplied as follows:
Bottles of 30
Bottles of 100 pcs.
500 bottles
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NORCO 10/325 Available as yellow capsule-shaped tablets, halved on one side and embossed with “NORCO 539” on the other side. Each tablet contains 10 mg hydrocodone bitartrate and 325 mg acetaminophen. They are supplied as follows:
Bottles of 100 pcs.
Bottles of 500
Store at 20°-25°C (68°-77°F). [See Room Temperature Controlled USP .]
Dispense in a tight, light-resistant container with a child-proof lid.
Watson Pharma, Inc., a subsidiary of Watson, Pharmaceuticals, Inc., Corona, CA 92880, USA, 14716. Revised: July 2007 Cardinal Health, Zanesville, OH 43701.
Side effects and drug interactions
SIDE EFFECTS
The most common adverse reactions are dizziness, sedation, nausea and vomiting. These effects appear to be more pronounced in outpatients than in general patients, and some of these adverse reactions may be alleviated by lying down.
Other adverse reactions include:
Central nervous system: Drowsiness, clouding of consciousness, lethargy, impaired mental and physical performance, anxiety, fear, dysphoria, mental dependence, mood changes.
Gastrointestinal: Prolonged administration of NORCO may cause constipation.
Genitourinary system: Spasm of the ureter, spasm of the vesical sphincter and urinary retention have been reported with opiates.
Respiratory depression: Hydrocodone bitartrate may cause dose-dependent respiratory depression by acting directly on the respiratory centers of the brainstem (see OVERDOSE ).
Special Senses: Hearing impairment or irreversible loss has been reported predominantly in patients with chronic overdose.
Dermatological: Skin rash, pruritus.
The following adverse events can be considered as potential effects of paracetamol: allergic reactions, rash, thrombocytopenia, agranulocytosis. Possible effects of high dosages are listed in the OVERDOSE section.
Drug abuse and dependence
Controlled substance
NORCO is classified as a Schedule III controlled substance.
Abuse and dependence
Mental dependence, physical dependence and tolerance may develop with repeated drug use; therefore, this product should be prescribed and administered with caution. However, psychic dependence is unlikely to develop with short-term use of NORCO for the treatment of pain.
Physical dependence, a condition that requires continued drug use to prevent withdrawal, only becomes clinically significant after several weeks of continuous drug use, although some mild degree of physical dependence may develop after a few days of use. drug therapy. Tolerability, in which higher and higher doses are required to obtain the same degree of pain relief, first manifests itself in a reduction in the duration of the analgesic effect, and then in a decrease in the intensity of pain relief. The rate of development of tolerance in different patients is different.
DRUG INTERACTIONS
Patients receiving other narcotics, antihistamines, antipsychotics, sedatives, or other CNS depressants (including alcohol) concomitantly with NORCO may exhibit additive CNS depression. If combination therapy is contemplated, the dose of one or both agents should be reduced.
The use of MAO inhibitors or tricyclic antidepressants with hydrocodone preparations may increase the effect of the antidepressant or hydrocodone.
Interactions with drugs / laboratory tests
Acetaminophen may give false positive results for 5-hydroxyindoleacetic acid in urine.
Warnings
WARNINGS
Respiratory depression
At high doses or in sensitive patients, hydrocodone may cause dose-dependent respiratory depression by acting directly on the respiratory center of the brainstem. Hydrocodone also affects the center that controls the respiratory rhythm and can cause irregular and periodic breathing.
Head trauma and increased intracranial pressure
The respiratory depressant effects of drugs and their ability to increase cerebrospinal fluid pressure may be markedly exaggerated in the presence of head trauma, other intracranial lesions, or a pre-existing increase in intracranial pressure. In addition, drugs cause adverse reactions that may obscure the clinical course of patients with head injuries.
Acute diseases of the abdominal cavity
Drug administration may obscure the diagnosis or clinical course of patients with acute abdominal conditions.
Precautions
PRECAUTIONS
General
Special Risk Patients
As with any narcotic analgesic, NORCO should be used with caution in elderly or debilitated patients and in patients with severe hepatic or renal impairment, hypothyroidism , illness Addison, prostatic hypertrophy or urethral stricture. The usual precautions should be observed and the possibility of respiratory depression should be kept in mind.
Cough reflex
Hydrocodone suppresses the cough reflex; As with all drugs, caution should be exercised when using NORCO in the postoperative period and in patients with pulmonary disease.
Laboratory tests
In patients with severe liver or kidney disease, the effect of therapy should be monitored by serial tests of liver and/or kidney function.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Adequate studies have not been conducted in animals to determine whether hydrocodone or acetaminophen has the potential to cause carcinogenesis, mutagenesis or impairment of fertility.
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Pregnancy
Teratogenic effects
Pregnancy category C
There are no adequate and well-controlled studies in pregnant women. NORCO should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Non-teratogenic effects
Infants born to mothers who regularly took opioids prior to birth will be physically dependent. Withdrawal signs include irritability and excessive crying, tremors, hyperactive reflexes, rapid breathing, rapid stools, sneezing, yawning, vomiting, and fever. The severity of the syndrome does not always correlate with the duration of maternal opioid use or dose. There is no consensus on how best to deal with withdrawal symptoms.
Handling and Delivery
As with all drugs, administration of this product to the mother shortly before delivery may result in some degree of respiratory depression in the neonate, especially at higher doses.
Nursing mothers
Acetaminophen is excreted in breast milk in small amounts, but the significance of its effects on infants is unknown. It is not known if hydrocodone is excreted in breast milk. Since many drugs are excreted in breast milk and because of the potential for serious adverse reactions in nursing infants to hydrocodone and acetaminophen, a decision should be made whether to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric use
Safety and efficacy in pediatric patients have not been established.
Geriatric Use
Clinical studies of hydrocodone bitartrate 5 mg and acetaminophen 500 mg did not include sufficient numbers of subjects aged 65 years and over to determine if they respond differently than younger subjects. Other reported clinical experience has found no difference in response between older and younger patients. In general, dose selection for the elderly patient should be cautious, usually starting at the lower end of the dosing range, reflecting a greater incidence of decreased hepatic, renal, or cardiac function, as well as concomitant disease or other drug therapy.
Hydrocodone and the main metabolites of acetaminophen are known to be primarily excreted by the kidneys. Thus, the risk of toxic reactions may be higher in patients with impaired renal function due to accumulation of the parent compound and/or metabolites in plasma. Because older patients are more likely to have decreased renal function, care should be taken in dose selection and it may be beneficial to monitor renal function.
Hydrocodone may cause confusion and excessive sedation in the elderly; Elderly patients should generally be initiated on low doses of hydrocodone bitartrate and acetaminophen tablets and monitored closely.
Overdose and contraindications
OVERDOSAGE
Acute overdose may cause toxic effects of hydrocodone or acetaminophen.
Signs and symptoms
Hydrocodone
Severe hydrocodone overdose is characterized by respiratory depression (decreased respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), severe drowsiness progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia, etc. hypotension. In severe overdose, sleep apnea, circulatory failure, cardiac arrest and death can occur.
Acetaminophen
Paracetamol overdose: Dose-dependent, potentially fatal liver necrosis is the most serious side effect. Renal tubular necrosis, hypoglycemic coma, and thrombocytopenia may also occur.
Early symptoms of a potentially hepatotoxic overdose may include nausea, vomiting, sweating and general malaise. Clinical and laboratory evidence of liver toxicity may not appear until 48-72 hours after ingestion.
In adults, liver toxicity has rarely been reported with acute overdoses of less than 10 grams or fatalities with doses of less than 15 grams.
Care
A single or multiple overdose of hydrocodone and acetaminophen is a potentially lethal overdose of polydrug addiction, so consultation with your local poison control center is recommended.
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Immediate treatment includes support for cardiorespiratory function and measures to reduce drug absorption. Vomiting should be induced mechanically or with ipecac syrup if the patient is alert (adequate pharyngeal and laryngeal reflexes). Activated charcoal by mouth (1 g/kg) should be taken after a gastric emptying. The first dose should be accompanied by appropriate laxatives. If repeated doses are used, the laxative may be added with other doses as needed. Hypotension is usually hypovolemic and must be fluid-responsive. Vasopressors and other supportive measures should be used as directed. A cuffed endotracheal tube should be inserted prior to gastric lavage in an unconscious patient and, if necessary, to provide assisted breathing.
Particular attention should be paid to maintaining adequate ventilation. In severe cases of intoxication, peritoneal dialysis or, preferably, hemodialysis may be considered. If hypoprothrombinemia occurs due to an overdose of acetaminophen, vitamin K should be given intravenously.
Naloxone, a drug antagonist, may reverse respiratory depression and coma associated with opioid overdose. Naloxone hydrochloride 0.4 mg to 2 mg is administered parenterally. Because the duration of action of hydrocodone may exceed that of naloxone, the patient should be monitored closely and repeated doses of the antagonist administered as needed to maintain adequate respiration.
The narcotic antagonist should not be used in the absence of clinically significant respiratory or cardiovascular depression.
If the dose of acetaminophen could exceed 140 mg/kg, acetylcysteine should be administered as soon as possible. Serum levels of paracetamol should be determined, as levels four or more hours after ingestion help predict paracetamol toxicity. Do not wait for acetaminophen test results before starting treatment. First you need to get liver enzymes, and then repeat them every 24 hours.
Methemoglobinemia greater than 30% should be treated with methylene blue by slow intravenous administration.
The adult toxic dose of paracetamol is 10 g.
CONTRAINDICATIONS
NORCO should not be used in patients with a history of hypersensitivity to hydrocodone or acetaminophen.
Patients with hypersensitivity to other opioids may show cross-sensitivity to hydrocodone.
Clinical pharmacology
CLINICAL PHARMACOLOGY
Hydrocodone is a semi-synthetic narcotic analgesic and antitussive with many actions qualitatively similar to those of codeine. Most of them affect the central nervous system and smooth muscles. The exact mechanism of action of hydrocodone and other opiates is unknown, although it is thought to be related to the existence of opiate receptors in the central nervous system. In addition to pain relief, drugs can cause drowsiness, mood changes, and clouding of the mind.
The analgesic action of paracetamol is associated with peripheral effects, but the specific mechanism has not yet been determined. The antipyretic effect is transmitted through the hypothalamic heat regulation centers. Acetaminophen inhibits prostaglandin synthetase. Therapeutic doses of paracetamol have little effect on the cardiovascular or respiratory systems; however, toxic doses can cause circulatory failure and shallow breathing.
Pharmacokinetics.
The behavior of the individual components is described below.
Hydrocodone
After oral administration of 10 mg hydrocodone to five adult males, the mean peak concentration was 23. 6 ± 5.2 ng/mL. Peak serum levels were reached at 1.3 ± 0.3 hours and the half-life was 3.8 ± 0.3 hours. Hydrocodone exhibits a complex metabolic pattern including O-demethylation, N-demethylation, and 6-ketoreduction to the corresponding 6-α- and 6-β-hydroxy metabolites. See OVERDOSE for toxicity information.
Acetaminophen
Acetaminophen is rapidly absorbed from the gastrointestinal tract and distributed to most body tissues. The plasma half-life ranges from 1.25 to 3 hours, but may increase with liver damage and after overdose. Excretion of paracetamol occurs mainly due to metabolism (conjugation) in the liver and subsequent excretion of metabolites by the kidneys. Approximately 85% of an oral dose is excreted in the urine within 24 hours of ingestion, primarily as the glucuronide conjugate with small amounts of other conjugates and unchanged drug. see OVERDOSE for toxicity information.
Medication Guide
PATIENT INFORMATION
Hydrocodone, like all drugs, may impair the mental and/or physical abilities required to perform potentially hazardous tasks such as driving a car or operating machinery; patients should be warned accordingly.
Alcohol and other CNS depressants may cause additional CNS depression when taken with this combination product and should be avoided.
Hydrocodone may be habit-forming. Patients should only take the drug for as long as it is prescribed, in the prescribed amounts, and no more frequently than prescribed.
Take the drug only for as long as it is prescribed, in the prescribed amounts and no more often than prescribed.
Norco vs Vicodin – Difference & Comparison – Health
Video: The Other Side of Vicodin
Contents
- Comparison Chart
- Composition
- Dosage
- Side effects
- Warnings
- Addiction
- Classification
- Prescriptions
Norco and Vicodin are common narcotic pain relievers that consist of two active ingredients, acetaminophen and hydrocodone. The levels of these two ingredients differ for each drug; Norco contains higher levels of hydrocodone while Vicodin contains higher levels of acetaminophen. The difference in these levels determines dosage recommendations and causes various side effects.
Comparison chart
Norco | Vicodin | |
---|---|---|
current rating 2.8 / 5 (178 ratings) | current rating 3.31 / 5 (425 ratings) | |
Generic name | Acetaminophen and hydrocodone | Acetaminophen and hydrocodone |
Dose | 1 every 4-6 hours as needed | 1-2 every 4-6 hours as needed |
Side effects | Drowsiness, upset stomach, constipation, headache, blurred vision, dry mouth, urticaria, difficulty breathing, swelling of the face, confusion, itching, slow heartbeat | Dizziness, drowsiness, mild nausea, constipation , blurred vision, dry mouth, headache, mood changes, tinnitus |
Uses | Moderate to severe pain relief | Moderate to severe pain relief |
Dependence | Addictive | Addictive |
Overdose | May cause liver damage and death | May cause liver damage and death |
Generic available | yes | yes |
Manufacturer | Actavis | AbbVie |
Other brands | Hycet, Lorcet, Lorcet Plus, Lortab, Maxidone, Norco, Vicodin, Vicodin ES, Vicodin HP, Zamicet and Zydone | Anexsia, Co-Gesic, Hycet, Liquicet, Lorcet, Maxidone, Norco, Polygesic, Stagesic, Xodol, Zemicet, Zolvit, Zydone 75 |
Website | http ://www. actavis.com/ | http://www.vicodin.com/, http://www.abbvie.com/ |
Composition
There are usually two types of Norco tablets: Norco 7.5/325 and Norco 10/325. The first consists of 7.5 mg of hydrocodone bitartrate and 325 mg of acetaminophen; the second simply contains an additional 2.5 mg of hydrocodone. Regardless of the type of Norco tablet, each Norco tablet contains a higher level of hydrocodone than a Vicodin tablet.
A typical Vicodin tablet consists of 5 mg hydrocodone bitartrate and 500 mg acetaminophen containing significantly higher levels of acetaminophen than Norco tablets.
Dosage
The usual adult dose of Norco is 1 tablet every four to six hours as needed, although actual recommendations are adjusted based on pain severity and patient response. The daily dosage should not exceed 6 tablets.
The usual adult dose of Vicodin is 1-2 tablets every four to six hours as needed, also varying according to the patient’s response. It is noteworthy that more Vicodin tablets can be used at one time than Norco tablets. The daily dose is also slightly higher than Norco’s, as Vicodin’s recommendations state that it should not exceed 8 tablets per day, while Norco only allows up to 6.
Overdose
Overdose of Norco and Vicodin can cause liver damage and death. Overdose signs include nausea, vomiting, abdominal pain, sweating, and confusion. Later symptoms include upper stomach pain, dark urine, and yellowing of the skin and eyes (jaundice).
Side effects
Side effects for each of these drugs are almost the same and include drowsiness, upset stomach, constipation, headache, blurred vision, dry mouth, hives, difficulty breathing, swelling of the face, confusion, itching, and slow heartbeat.
Vicodin is slightly different from Norco in that the chance of stomach problems is much higher in patients taking Vicodin due to higher paracetamol levels. Some doctors will change prescriptions to Norco for patients who have stomach problems while taking Vicodin.
Warnings
Norco and Vicodin have the same important warnings. Those who have ever had alcoholic liver disease or who have consumed more than three alcoholic drinks a day should not take this medicine without consulting a doctor. People taking them should not drink alcohol, as this increases the risk of liver disease. These drugs can also cause breathing problems and addiction/withdrawal symptoms in newborns, so pregnant women should check with their doctor before taking them. Neither should be taken with other narcotic pain relievers, sedatives, hypnotics, or muscle relaxants.
Addiction
Due to the mood-altering effects of Norco and Vicodin, both drugs are addictive. If people suddenly stop taking these drugs after long-term use, they may suffer withdrawal symptoms. None of the substances is significantly more addictive than the other, since their composition is almost the same.
However, due to the higher concentration of hydrocodone in Norco tablets, patients taking these tablets may potentially experience the addictive properties of the previously used drug.