What is the recommended dosage for acyclovir. How should acyclovir be taken for optimal effectiveness. What are the proper administration methods for different forms of acyclovir. What precautions should be taken when using acyclovir.

Understanding Acyclovir: A Powerful Antiviral Medication

Acyclovir is a widely prescribed antiviral medication used to treat various viral infections, particularly those caused by herpes simplex virus (HSV) and varicella-zoster virus (VZV). It’s available in multiple forms, including oral tablets, capsules, liquid suspension, topical creams, and intravenous solutions. The focus of this article is on the oral route administration, specifically the 800 mg dosage taken five times a day.

The Importance of Proper Dosage: 800 mg Acyclovir 5 Times Daily

The dosage of 800 mg acyclovir taken five times daily is a common prescription for severe viral infections. This high-frequency, high-dose regimen is designed to maintain a consistent level of the drug in the body, maximizing its antiviral effects. However, it’s crucial to understand that dosages can vary depending on the specific condition being treated and individual patient factors.

Why is the 800 mg dose taken so frequently?

The 800 mg dose taken five times daily is prescribed to maintain therapeutic levels of acyclovir in the bloodstream. Acyclovir has a relatively short half-life in the body, meaning it’s eliminated quickly. By taking the medication every few hours, patients can ensure that there’s always enough of the drug present to combat the viral infection effectively.

Proper Administration of Acyclovir Tablets

When taking acyclovir tablets, it’s essential to follow your healthcare provider’s instructions carefully. Here are some general guidelines for proper administration:

• Take the tablets with or without food
• Drink plenty of water to help keep your kidneys functioning well
• Swallow the tablets whole with a drink of water
• If you have difficulty swallowing, you can dissolve the tablets in water
• Try to space your doses evenly throughout the day

How should I space my doses throughout the day?

For a five-times-daily regimen, you could take your doses at approximately 7am, 11am, 3pm, 7pm, and 11pm. This schedule helps maintain consistent levels of the medication in your system. However, always consult with your healthcare provider for personalized advice on timing your doses.

Duration of Treatment with Acyclovir

The duration of acyclovir treatment can vary depending on the condition being treated and its severity. For acute viral infections, treatment typically lasts 5 to 10 days. However, in some cases, especially for prevention of recurrent infections, long-term use may be necessary.

How long should I continue taking acyclovir?

It’s crucial to complete the entire course of treatment prescribed by your doctor, even if your symptoms improve before the medication is finished. Stopping the medication too early can lead to a resurgence of the viral infection and potentially contribute to drug resistance.

Alternative Forms of Acyclovir: Creams and Eye Ointments

While this article focuses primarily on oral acyclovir, it’s worth noting that the medication is also available in topical forms for treating specific conditions:

Acyclovir Cream for Cold Sores

For cold sores, acyclovir cream is typically applied five times daily for at least 4 days, and up to 10 days if necessary. Apply a thin layer to the affected area, washing your hands before and after application.

Acyclovir Cream for Genital Herpes

When treating genital herpes, apply a thin layer of acyclovir cream to the affected area five times daily for at least 5 days, and up to 10 days if needed. Always wash your hands before and after application.

Acyclovir Eye Ointment

For eye infections, acyclovir eye ointment is usually applied five times daily. Gently pull down your lower eyelid and apply about 1 centimeter of ointment into the space between your lower lid and your eye. Continue treatment for at least 3 days after your eye has improved.

Potential Side Effects and Precautions

While acyclovir is generally well-tolerated, like all medications, it can cause side effects. Common side effects may include:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Dizziness

More serious side effects are rare but can occur. It’s important to contact your healthcare provider if you experience any unusual or severe symptoms while taking acyclovir.

Can acyclovir interact with other medications?

Yes, acyclovir can interact with certain medications. It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking. Some drugs that may interact with acyclovir include:

• Probenecid
• Certain antibiotics
• Other antiviral medications

Missed Doses and Overdose Information

If you miss a dose of acyclovir, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Never double up on doses to make up for a missed one.

What should I do if I take too much acyclovir?

Taking too much acyclovir is unlikely to cause serious harm unless done consistently over several days. However, if you’re concerned about an overdose, contact your healthcare provider or local poison control center immediately for advice.

Special Considerations for Acyclovir Use

Certain groups of people may need special consideration when using acyclovir:

• Pregnant or breastfeeding women should consult their healthcare provider before using acyclovir
• Elderly patients may need dose adjustments due to decreased kidney function
• People with kidney problems may require lower doses
• Individuals with a history of neurological problems should use acyclovir with caution

Is acyclovir safe for use during pregnancy?

While acyclovir is generally considered safe during pregnancy, it’s crucial to discuss the potential risks and benefits with your healthcare provider. They can provide personalized advice based on your specific situation and health history.

Effectiveness of Acyclovir in Viral Infections

Acyclovir has proven to be highly effective in treating various viral infections, particularly those caused by herpes simplex virus (HSV) and varicella-zoster virus (VZV). It works by interfering with the virus’s ability to replicate, thereby reducing the severity and duration of symptoms.

How quickly does acyclovir start working?

While individual responses can vary, many people start to notice an improvement in their symptoms within a few days of starting acyclovir treatment. However, it’s important to complete the entire course of medication as prescribed, even if symptoms improve before the medication is finished.

Acyclovir Resistance: An Emerging Concern

As with many antimicrobial medications, there is growing concern about the development of acyclovir-resistant strains of viruses. This underscores the importance of using the medication exactly as prescribed and completing the full course of treatment.

How can acyclovir resistance be prevented?

To help prevent the development of acyclovir-resistant viruses:

• Always take the full course of medication as prescribed
• Don’t use acyclovir for viral infections it’s not intended to treat
• Avoid sharing your medication with others
• Practice good hygiene to prevent the spread of viral infections

The Future of Antiviral Therapy: Beyond Acyclovir

While acyclovir remains a cornerstone of antiviral therapy, research continues into new and improved treatments for viral infections. Some areas of ongoing research include:

• Development of new antiviral compounds
• Exploration of combination therapies
• Investigation of immune-boosting strategies
• Research into viral mechanisms to identify new drug targets

Are there any new antiviral medications on the horizon?

Several new antiviral medications are currently in various stages of development and clinical trials. These include novel compounds that target different aspects of viral replication and drugs that boost the body’s own immune response to viral infections. However, it’s important to note that the development and approval process for new medications can take many years.

Acyclovir in the Context of Global Health

Acyclovir plays a crucial role in global health efforts, particularly in managing herpes virus infections. Its availability and affordability make it an important tool in combating viral diseases worldwide. However, challenges remain in ensuring access to this medication in all parts of the world.

How does acyclovir contribute to global health initiatives?

Acyclovir contributes to global health in several ways:

• Reducing the burden of herpes virus infections
• Preventing complications of viral infections, particularly in immunocompromised individuals
• Helping to control the spread of viral infections in communities
• Providing a cost-effective treatment option for viral diseases

Patient Education and Acyclovir Use

Proper patient education is crucial for the effective use of acyclovir. Healthcare providers play a key role in ensuring that patients understand how to take the medication correctly, what side effects to watch for, and when to seek medical attention.

What are some key points patients should know about acyclovir?

Important points for patients to remember include:

• Take the medication exactly as prescribed
• Complete the full course of treatment
• Stay well-hydrated while taking acyclovir
• Report any unusual side effects to your healthcare provider
• Inform your doctor about all other medications you’re taking

Acyclovir and Lifestyle Considerations

While taking acyclovir, certain lifestyle considerations may help improve treatment outcomes and overall health:

• Maintaining a healthy diet to support immune function
• Getting adequate rest to aid in recovery
• Managing stress, which can impact immune function
• Avoiding triggers that may exacerbate viral outbreaks

Can lifestyle changes enhance the effectiveness of acyclovir treatment?

While acyclovir is effective on its own, certain lifestyle changes may complement its action. Maintaining a healthy lifestyle can support your immune system, potentially enhancing your body’s ability to fight off viral infections. However, these measures should be seen as complementary to, not replacements for, prescribed medical treatment.

How and when to take or use aciclovir

Dosage for aciclovir tablets and liquid

Doses will vary, depending on why you’re taking aciclovir. Your doctor will tell you how much to take and how often.

A single dose is generally between 200mg and 800mg. Doses may be lower for children.

You’ll usually take aciclovir 2 to 5 times a day. Try to space your doses evenly throughout the day.

If you take aciclovir:

• 4 times a day – you could take it first thing in the morning, at midday, in the late afternoon and at bedtime
• 5 times a day – you could take it at 7am, 11am, 3pm, 7pm and 11pm, for example

Keep taking the medicine until it’s all finished or until your doctor or pharmacist tells you to stop taking it.

For treating a viral infection, you’ll usually take aciclovir for 5 to 10 days. For prevention, you may need to take it for a long time.

How to take tablets and liquid

You can take aciclovir tablets or liquid with or without food. Drink plenty of water while taking this medicine to help keep your kidneys working well.

Swallow the tablets whole with a drink of water.

If you find tablets difficult to swallow, you can dissolve them in water. Add a tablet to a small glass of water and stir. Drink all the liquid to make sure you get the full dose.

Aciclovir liquid will come with a measuring spoon or plastic syringe to help you measure your dose. If you do not have a measuring spoon or syringe, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not measure the right amount of medicine.

How to use cream for cold sores

Wash your hands before and after using the cream.

Put a thin layer of cream on the cold sore 5 times a day. Do this every 4 hours – for example, at 7am, 11am, 3pm, 7pm and 11pm.

Do not put aciclovir cream inside your mouth, in your eyes or vagina.

Use the cream for at least 4 days. If the cold sore has not healed by then, you can carry on using the cream for another 6 days.

If the cold sore still has not healed after a total of 10 days, stop using the cream and tell your doctor.

How to use cream for genital herpes

Wash your hands before and after using the cream.

Put a thin layer of cream on the affected area 5 times a day. Do this every 4 hours – for example, at 7am, 11am, 3pm, 7pm and 11pm.

Use the cream for at least 5 days. If the genital herpes sore has not healed by then, you can carry on using the cream for another 5 days.

If the affected area has still not healed after a total of 10 days, stop using the cream and tell your doctor.

How to use eye ointment

Put the ointment in the affected eye 5 times a day, or as your doctor advises.

1. Wash your hands.
2. Gently pull down your lower eyelid and tilt your head back.
3. Hold the tube with the nozzle close to your eye and gently squeeze about 1 centimetre of ointment into the space between your lower lid and your eye.
4. Close your eye for a few minutes.

Try not to let the tip of the eye ointment tube touch any part of your eye. This is to keep it free from germs.

Space the times when you use the eye ointment evenly throughout the day – for example at 7am, 11am, 3pm, 7pm and 11pm.

Keep using the eye ointment for at least 3 days after your eye has got better.

If you wear contact lenses, do not use them while you’re using the eye ointment. This is because some medicines or preservatives in eye ointments can build up in contact lenses and may damage them.

Your vision might become a little blurred after you use the eye ointment. Blink several times after putting the eye ointment in to help clear your vision. Do not drive, cycle or use any tools or machinery until you can see clearly again.

If you forget to take or use it

If you forget a dose of aciclovir, take it (or use the cream or eye ointment) as soon as you remember, unless it’s nearly time for your next dose. In this case, just skip the missed dose and continue with your next one at the usual time.

Never have 2 doses at the same time. Never have an extra dose to make up for a forgotten one.

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicines.

If you take or use too much

Using too much aciclovir cream or eye ointment is unlikely to harm you.

Taking too many aciclovir tablets or too much liquid is also unlikely to harm you, unless you do so over several days.

Talk to your doctor or pharmacist if you’re worried that you have had too much aciclovir.

Side Effects, Dosage, Uses, and More

Highlights for acyclovir

1. Acyclovir oral tablet is only available as a generic drug. It doesn’t have a brand-name version.
2. Acyclovir is also available as a capsule, suspension, and buccal tablet that you take by mouth. It also comes in a cream and ointment you apply to your skin. In addition, acyclovir is available as an intravenous (IV) drug, which is only given by a healthcare professional.
3. Acyclovir is used to treat viral infections. These include herpes zoster (shingles), genital herpes, and varicella (chickenpox).

• Kidney failure: This drug may cause your kidneys to stop working. Tell your doctor if you have any kidney problems before taking this medication.
• Low red blood cells and platelets: This drug may cause thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). These conditions cause dangerously low levels of red blood cells and platelets in your body. This may be fatal (cause death). Symptoms can include fatigue and low energy.
• Sexual contact: You shouldn’t have sexual contact with your partner when you have signs of a genital herpes outbreak. This drug does not cure herpes infections. It may help lower the chance of spreading herpes to your partner. However, even with safe sex practices, it’s still possible to spread genital herpes. Talk to your doctor for information about safe sex practices.

Acyclovir oral tablet is a prescription drug that’s only available in a generic form. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Acyclovir also comes as an oral capsule, oral suspension, buccal tablet, topical cream, and topical ointment. In addition, acyclovir is available as an intravenous drug, which is only given by a healthcare professional.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it’s used

Acyclovir is used to treat viral infections. These include herpes zoster (shingles), genital herpes, and varicella (chickenpox).

This drug doesn’t cure herpes infections. The herpes virus can stay in your body for a long time and cause symptoms again later.

How it works

Acyclovir belongs to a class of drugs called antivirals. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Acyclovir works by lowering the ability of the herpes virus to multiply in your body. This treats the symptoms of your infection. However, this drug doesn’t cure herpes infections. Herpes infections include cold sores, chickenpox, shingles, or genital herpes. Even with this drug, the herpes virus may still live in your body. Your symptoms may occur again later even after the symptoms of your current infection go away.

Acyclovir oral tablet doesn’t cause drowsiness but it can cause other side effects.

More common side effects

Some of the more common side effects of acyclovir oral tablet include:

• nausea
• vomiting
• diarrhea
• headache
• weakness

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Unusual changes in your mood or behavior. Symptoms can include:
  • aggressive behavior
  • unsteady or shaky movements
  • confusion
  • trouble speaking
  • hallucinations (seeing or hearing something that isn’t there)
  • seizures
  • coma (being unconscious for a long time)
• Decrease in your red blood cells and platelets. Symptoms can include:
  • fatigue
• Liver problems
• Muscle pain
• Skin reactions. Symptoms can include:
  • hair loss
  • rash
  • breaking or loosening of skin
  • hives
  • Stevens-Johnson syndrome. This is a rare, allergic skin reaction.
• Changes in your vision
• Kidney failure. Symptoms can include:
  • kidney or flank pain (pain in your side and back)
  • blood in your urine
• Allergic reaction. Symptoms can include:
  • trouble breathing
  • swelling of your throat or tongue
  • rash
  • hives

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. To help prevent interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking.

To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

Acyclovir can cause a severe allergic reaction. Symptoms can include:

• trouble breathing
• swelling of your throat or tongue
• rash
• hives

Call 911 or go to the nearest emergency room if you develop these symptoms. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Warnings for certain groups

For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects.

This medication may also decrease your kidney function. This means your kidney disease may get worse. Your doctor will adjust your dose depending on how well your kidneys are working.

For pregnant women: Acyclovir is a category B pregnancy drug. That means two things:

1. Studies of the drug in pregnant animals have not shown a risk to the fetus.
2. There aren’t enough studies done in pregnant women to show if the drug poses a risk to the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should be used only if the potential benefit justifies the potential risk to the fetus.

Call your doctor right away if you become pregnant while taking this drug.

For women who are breastfeeding: Acyclovir may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

For children: This drug hasn’t been studied in children younger than 2 years.

This dosage information is for acyclovir oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Forms and strengths

Generic: Acyclovir

• Form: oral tablet
• Strengths: 400 mg, 800 mg

Dosage for shingles, genital herpes, or chickenpox

Adult dosage (ages 18–64 years)

• Shingles typical dosage: 800 mg every 4 hours, five times per day for 7–10 days.
• Genital herpes:
  • Typical initial dosage: 200 mg every 4 hours, five times per day, for 10 days.
  • Typical dosage for prevention of recurrent herpes: 400 mg twice per day, every day for up to 12 months. Other dosing plans may include doses ranging from 200 mg three times daily to 200 mg five times daily. Your doctor will decide how long you should take this drug to avoid a flare-up of the infection.
  • Typical dosage for reinfection (flare-up of the infection): 200 mg every 4 hours, five times per day, for 5 days. You should take this drug as soon as the first signs of a flare-up appear.
• Chickenpox typical dosage: Take 800 mg four times per day for 5 days. Start this drug as soon as your first symptom of chickenpox appears. It isn’t known if this drug is effective if you start it more than 24 hours after the first sign of chickenpox.

Child dosage (ages 2–17 years)

• Chickenpox typical dosage:
  • Children who weigh 40 kg (88 lbs) or less: 20 mg/kg of body weight, given four times per day for 5 days
  • Children who weigh more than 40 kg: 800 mg four times per day for 5 days

Start this drug as soon as the first symptom of chickenpox appears. It isn’t known if this drug is effective if your child starts it more than 24 hours after the first sign of chickenpox.

Child dosage (ages 0–1 years)

It hasn’t been confirmed that acyclovir is safe and effective for children younger than 2 years.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.

Acyclovir oral tablet is used for short-term treatment of genital herpes, shingles, and chicken pox. It’s used for long-term treatment of recurring genital herpes. This drug comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: The symptoms of your infection may not get better or may get worse.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. If you’re taking this drug to prevent flare-ups of your infection, a certain amount needs to be in your body at all times. You shouldn’t stop taking this drug without talking to your doctor first.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

If you take too much: You could have dangerous levels of the drug in your body and experience more severe side effects. If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

How to tell if the drug is working: The symptoms of your infection will get better.

Keep these considerations in mind if your doctor prescribes acyclovir oral tablet for you.

General

• Take this drug at the time(s) recommended by your doctor.
• You can take acyclovir with or without food. Taking it with food may help reduce upset stomach.
• Do not cut or crush this medication.
• Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Storage

• Store this drug at room temperature. Keep it between 59°F and 77°F (15°C and 25°C).
• Keep it away from light.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t hurt your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:

• Kidney function. Your doctor may do blood tests to check how well your kidneys are working. If your kidneys aren’t working well, your doctor may lower your dose of this drug.
• Mental health and behavioral problems. You and your doctor should watch for any unusual changes in your behavior and mood. This drug can cause new mental health and behavior problems. It can also worsen problems you already have.

Your diet

You should drink plenty of water to stay hydrated. This drug can harm your kidneys if you don’t stay well hydrated.

Sun sensitivity

Acyclovir can make your skin more sensitive to the sun. This increases your risk of sunburn. Avoid the sun if you can. If you can’t, be sure to wear protective clothing and apply sunscreen.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Article resources

what it is used for, dosage and instructions for use

Contents

• 0
• 1.1.2 Dosage and administration
• 1.1.3 Answers to some questions

1.2 What is aciclovir?

1.3 What aciclovir is used for

1.4 Forms of aciclovir: advantages and disadvantages

• 1.4.1 Tablets
• 1.4.2 Cream
• 1.4.3 Ointment
• 1.4.4 Injection solution

1.5 How to take aciclovir 900 correctly 10

1.6 Dosage of acyclovir

1.7 Side effects when using acyclovir

1.8 Contraindications to the use of acyclovir

• 1.8.1 Individual intolerance to the drug
• 1.8.2 Hypersensitivity to valaciclovir and other antiviral drugs
• 1.8.3 Pregnancy and breast-feeding
• 1.8.4 Renal failure

1.9 Pregnancy and lactation with acyclovir

• 1.9.1 Pregnancy
• 1.9 .2 Breastfeeding

1. 10 Interactions of aciclovir with other drugs

1.11 Storage of aciclovir

1.12 Where can aciclovir be purchased?

1.13 Related videos:

1.14 Q&A:

• • 1.14.0.1 How to use aciclovir correctly?
  • 1.14.0.2 Can aciclovir be used to prevent herpes?
  • 1.14.0.3 What side effects can be associated with the use of aciclovir?
  • 1.14.0.4 How does acyclovir aciclovir work?
  • 1.14.0.5 What dosage of aciclovir is prescribed for herpes in pregnant women?
  • 1.14.0.6 How long is aciclovir effective after the end of the dose?

Instructions for use of the antiviral drug Acyclovir (Aciclovir). Dosage, indications for use, possible side effects and methods of application. Get detailed information about the drug Acyclovir on our website.

Aciclovir (or aciclovir) is a drug that is an important drug in the field of infectious medicine. This drug is used to fight viral infections, including herpes and shingles.

The drug is applied topically, in the form of an ointment, and orally, in the form of tablets. The internal use of acyclovir allows you to quickly and effectively treat herpetic viral infections that are in an advanced stage.

The use of acyclovir ointment allows the treatment of mild herpes and does not affect the internal organs of a person. Accordingly, this makes acyclovir ointment the best medical remedy available for the treatment of a disease in its initial stage.

Despite a productive treatment, like any other medicine, aciclovir has contraindications and side effects that you should be aware of. For example, in the case of an allergy to connective tissue in a patient, the drug is strongly not recommended.

Aciclovir: instructions for use

Presentation forms

Acyclovir is an antiviral agent available in various forms of presentation:

• tablets;
• ointment;
• capsules;
• injection;
• cream;
• oral suspension.

Dosage and administration

The dosage of acyclovir is determined by the attending physician, depending on the severity of the disease and the individual characteristics of the patient.

Tablets are usually taken by mouth with plenty of water. Capsules are taken whole, without chewing.

Ointment and cream are applied to the affected areas of the skin in a thin layer. For injections, only the usual method of administration is used – it is injected into a vein. The oral suspension is taken with water.

Some questions answered

How long should I take aciclovir?

The course of treatment for each patient may be individual and depends on the characteristics of the disease. Consultation with the attending physician is necessary to determine the exact timing of taking the drug.

What should I do if I forget to take aciclovir?

If the missed dose is less than two hours, it can be taken as soon as possible. If it has been a long time since you missed a dose, you should consult your doctor.

Are there side effects from taking acyclovir?

Aciclovir may cause side effects such as headache, nausea, vomiting, diarrhea, fever and many others. At the first symptoms, you should consult a doctor.

What is acyclovir?

Aciclovir is a medicine used to fight viral infections. It belongs to the group of antiviral drugs and is used to treat diseases such as herpes and shingles.

Aciclovir is an inhibitor of viral polymerases, which allows it to prevent the replication of the virus and reduce the risk of infection. The drug also speeds up the healing process and shortens the duration of the disease, making it an effective tool in the fight against viruses.

Aciclovir is available in various forms such as tablets, ointments and injections. As a rule, its use is recommended in accordance with the instructions of the doctor and after the necessary laboratory tests have been carried out.

What aciclovir is used for

Aciclovir is an antiviral medicine used to treat infections caused by certain viruses. It is widely used to treat herpes and herpes zoster caused by the Varicella zoster virus.

In some cases, acyclovir may be given to prevent herpes in people who are immunocompromised, such as in patients with HIV infection or after organ transplants.

1. Treatment of herpes
2. Treatment of herpes zoster
3. Prevention of herpes in people with immunodeficiency

Formulations of acyclovir: advantages and disadvantages

Tablets

Aciclovir tablets are one of the most commonly used formulations. They have high bioavailability and quickly act on the virus. The disadvantage is the need to take them on a schedule for several days. Also, tablets are not recommended for people with impaired kidney function.

Cream

Topical aciclovir cream is beneficial in the treatment of herpes sores and skin rashes. It quickly has a local effect on the affected area. The disadvantage is the need to reapply several times a day.

Ointment

Acyclovir ointment is suitable for the treatment of skin disorders and herpes zoster. It is applied to the affected area and is quickly absorbed, which provides a quick effect on the virus. The disadvantage is the lack of versatility – the ointment cannot be used for herpes on the lips or for the treatment of genital herpes.

Injection

Aciclovir injection is rarely used and is reserved for severe disease. It gives a quick and effective effect, but its use requires the advice of a doctor. The disadvantage is the high risk of side effects and a large number of contraindications.

How to take aciclovir correctly

Aciclovir is an antiviral medicine often used to treat infections caused by the herpes virus. Before you start using acyclovir, you should read the instructions and consult with your doctor.

If you forget to take a dose, do not try to double the dose next time. In this case, you should skip the missed dose and continue taking the medicine as usual.

If you have acute symptoms associated with a herpes infection, your doctor may decide to give you an additional course of acyclovir for a short period of time. In this case, follow your doctor’s advice.

Remember that aciclovir is a medical product and should only be used as directed by a doctor. It is not recommended to exceed the recommended dose or continue taking it for a longer period than recommended.

Dosage of acyclovir

Dosage of acyclovir depends on the form of release, the age of the patient and the severity of the disease. It is important to follow the doctor’s recommendations and not change the dosage on your own.

For the treatment of herpes simplex on the lips in adults and children over 2 years of age, apply acyclovir cream externally to the affected areas of the skin 5 times a day for 5-10 days. To prevent relapse, the drug is applied 4 times a day.

In the treatment of herpes zoster, the dosage of acyclovir may be increased to 800 mg 5 times a day. Treatment lasts from 7 to 10 days.

In case of impaired renal function, the dosage of aciclovir should be adjusted according to the plasma creatinine level.

You can find visual information on the dosage of acyclovir in the table below.

Dosage of acyclovir for adults and children Form of release of the drug Dosage Frequency of administration Duration of the course0218

5 times a day 5-10 days Tablets 200 mg, 400 mg, 800 mg 200-800 mg 5 times a day 5-10 days (shingles – 7-10 days)

Side effects when using aciclovir

Aciclovir is a safe and well tolerated drug, but in rare cases it can cause unwanted side effects. Some of them can be serious and require immediate medical attention.

• Allergic reactions – one of the most serious side effects are allergic reactions, including hives, swelling of the lips, tongue and throat, difficulty breathing. If you develop these symptoms, contact your doctor immediately.
• Vision problems – In rare cases, patients receiving high doses of acyclovir may experience vision problems such as blurred vision and double vision. If you experience these symptoms, stop taking the medicine and contact your doctor.
• Digestive problems – Some patients may experience stomach and intestinal problems such as nausea, vomiting and diarrhea. Seek medical attention if symptoms persist or worsen.
• Nervous system problems – sometimes aciclovir can cause dizziness, headache, impaired absorption and memory of information. If you experience these symptoms, check with your doctor.

If you have any unusual reaction while taking acyclovir, be sure to tell your doctor. Do not change the dosage or stop taking the medicine without your doctor’s permission.

Contraindications to the use of acyclovir

Individual intolerance to the drug

The use of acyclovir is contraindicated in case of individual intolerance to any of the components of the drug. Patients who experience allergic reactions while taking acyclovir should immediately stop taking the drug and consult a doctor for alternative treatment.

Hypersensitivity to valaciclovir and other antiviral drugs

Aciclovir is not recommended for patients with hypersensitivity to valaciclovir and other antiviral drugs. To select the optimal treatment, you need to consult a doctor.

Pregnancy and breastfeeding

The use of acyclovir during pregnancy and breastfeeding may be contraindicated. Before you start taking the drug, you should consult with your doctor and evaluate the indications and benefits of treatment.

Renal failure

In the presence of renal insufficiency, it is necessary to adjust the dose of acyclovir in accordance with the level of creatinine in the blood. With a significant decrease in kidney function, it is necessary to stop taking the drug.

Features of the use of acyclovir in pregnant and lactating women

Pregnancy

The use of acyclovir is critical for pregnant women suffering from viral herpes. However, the use of the drug should occur only under the supervision of a physician. It is necessary to take into account indications for use, possible side effects and duration of use. In some cases, widely used pharmacological drugs of a similar nature can become alternative methods of treatment.

Breast-feeding

When lactating, the use of acyclovir is possible with minor reservations. Data on its penetration into mother’s milk have not yet been unambiguously confirmed. However, pediatricians claim that even in small quantities, acyclovir does not adversely affect the health of a newborn child.

If treatment of herpes infection in a nursing mother is necessary, it is recommended to interrupt breastfeeding while taking acyclovir. At this time, alternative ways of feeding the baby, such as from a pacifier, bottle or spoon, should be used.

Interactions of acyclovir with other drugs

Acyclovir may interact with other drugs, so you should consult a doctor before starting its use.

The drug may increase the effect of probenecid, which is used in the treatment of joint diseases and pancreas.

Drugs that reduce the excretion of acyclovir from the body include cimetidine, probenecid, amitriptyline, nazivin, theophylline, ranitidine, and antiepileptic drugs.

Simultaneous use of acyclovir with sodium microphosphonate, which is used in the treatment of osteoporosis, may lead to an increase in the toxic effect of the antiviral drug.

The use of acyclovir together with deoxyguanosine may increase the toxicity of both drugs.

In general, the use of acyclovir should not be accompanied by concomitant use of other drugs without consulting a doctor.

Storage of aciclovir

Proper storage of aciclovir is essential to maintain the quality of the medicinal product and to maximize its effectiveness.

After purchase, place the drug in the original packaging and keep it out of the reach of children, at a temperature not exceeding +25 degrees Celsius.

Do not allow the medicine to freeze and do not store it in a damp place such as a bathroom. It is also important to avoid direct exposure to sunlight on the packaging of acyclovir.

Do not use aciclovir if the package has been damaged or if storage has not been as recommended. Also, do not exceed the expiration date of the medication.

If you need to throw away unwanted tablets or cream, do it the right way: seal the package and throw it in the trash with a zip-top lid, or take it to a pharmacy waste collection point.

Where can I buy acyclovir?

Acyclovir is an indispensable drug for the treatment of viral infections. If you need to buy acyclovir, you can go to pharmacies or online stores.

In pharmacies you can find aciclovir from different manufacturers: domestic and foreign. Prices for the drug may vary slightly in different pharmacies.

Online stores also offer home delivery of aciclovir. Some of them offer free shipping nationwide.

When choosing an online store to buy acyclovir, pay attention to the reputation of the seller, the availability of quality certificates for the product and the ability to pay upon receipt.

• List of some online stores for buying aciclovir:0015

  Do not forget that acyclovir is a drug that requires a doctor’s prescription. Therefore, before buying acyclovir, be sure to consult your doctor and get recommendations on the use of this medication.

  Related videos:

  Q&A:

  How to use aciclovir correctly?

  For the treatment of herpes simplex, aciclovir 200 mg 5 times a day for 5 days is usually given. For the treatment of herpes zoster, 800 mg of acyclovir is taken 5 times a day for 7-10 days. In any case, you must follow the doctor’s instructions and do not exceed the recommended dosage.

  Can aciclovir be used to prevent herpes?

  Yes, aciclovir can be taken as a prophylaxis for herpes. To do this, take 200-400 mg of acyclovir one to five times a day (depending on the frequency of relapses) for a saxonated period of time.

  What side effects can be associated with the use of acyclovir aciclovir?

  Some adverse effects may occur with the use of aciclovir, such as nausea, vomiting, headache, dizziness, diarrhea, constipation, and in some cases, skin rashes. If you notice these symptoms, you should consult your doctor.

  How does aciclovir work?

  Acyclovir aciclovir is an antiviral drug that reduces the multiplication of the herpes virus. It blocks the enzymes necessary for the virus to multiply and causes the virus to stop its activity.

  What dosage of acyclovir aciclovir is prescribed for herpes in pregnant women?

  The dosage may vary depending on the general condition of the patient and the stage of pregnancy. The usual dose is 400 mg of acyclovir three times a day for 7-10 days. But aciclovir should only be taken as prescribed by a doctor and after carefully weighing the risks and benefits.

  How long is aciclovir effective after the end of the dose?

  The effectiveness of acyclovir aciclovir is evaluated individually and depends on many factors, including the severity of the disease, the degree of infection, and individual sensitivity to the drug. Usually, however, the effect persists for several days after the end of the intake, but until the state of health is fully restored.

  Ulcaril 800 mg No. 25 tab

  Instructions for medical use of the medicinal product

  Trade name
  ULCARIL® 200
  ULCARIL® 400
  ULCARIL® 800

  International nonproprietary name
  Aciclovir

  Dosage form
  Tablets, 200 mg , 400 mg and 800 mg

  Composition
  One tablet contains
  active substance – acyclovir 208.00 mg (equivalent to acyclovir 200 mg), or 416. 00 mg (equivalent to acyclovir 400 mg), or 832.00 mg (equivalent to acyclovir 800 mg)
  excipients: lactose monohydrate, sodium starch glycolate type A (Explotab), corn starch, magnesium stearate

  Description
  White round tablets with a biconvex surface (for a dosage of 200 mg).
  White, round, biconvex tablets, scored on one side and marked “NOBEL” on the other (for a dosage of 400 mg).
  White, oblong, biconvex tablet, scored on one side (for 800 mg dosage).

  Pharmacotherapeutic group
  Antivirals for systemic use. Nucleosides and nucleotides. Acyclovir.
  ATC code J05AB01

  Pharmacological properties
  Pharmacokinetics
  When taken orally, regardless of food intake, acyclovir is partially absorbed from the gastrointestinal tract (20%). The maximum concentration in blood plasma is determined after 1.5 – 2 hours. Mean peak plasma concentrations after repeated oral administration of 200 mg, 400 mg, 800 mg of acyclovir 5 times a day every 4 hours is 3. 02 ± 0.5 µmol/l (200 mg), 5.21 ± 1.32 µmol/l ( 400mg). These values ​​are reached after approximately 1.5 ± 0.6 hours. The concentration of acyclovir in plasma 4 hours after a single oral dose of acyclovir is 1.61 ± 0.3 µmol/l (200 mg), 2.59± 0.53 µmol/L (400 mg). 24 hours after stopping taking acyclovir, the drug is completely eliminated from the body.
  In immunosuppressed children aged 3 to 11 years after oral acyclovir 400 mg, ie. 300 – 650 mg acyclovir / m2.
  Body surfaces, 5 times a day, mean peak plasma concentrations are 5.7 – 15.1 µmol/L. In infants aged 1 to 6 weeks, after oral administration of 600 mg acyclovir/m2 body surface area every 6 hours, peak plasma concentrations were 17.3 or 8.6 µmol/L. Acyclovir in high concentrations penetrates the tissues and is slowly excreted from them. Acyclovir crosses the blood-brain and placental barriers and is excreted in breast milk.
  The volume of distribution is 50 ± 8.7 l / 1.73 m2 in adults and 28.8 ± 9.3 l / 1.73 m2 in newborns and infants up to 3 months. Plasma protein binding ranged between 9 and 33%.
  Distribution
  The highest concentrations of acyclovir are achieved in the intestines, kidneys, liver and lungs, and the lowest – in the muscles, heart, brain, ovaries and testes of animals.
  Aciclovir accumulates in saliva, vaginal secretions, vesicular fluid of herpetic vesicles, and also in some organs. The concentration of the drug in the cerebrospinal fluid is 50% of the serum concentration.
  Metabolism and elimination
  In patients with normal renal function, 62-91% of acyclovir is excreted through the kidneys unchanged, and 10-15% in the form of 9-carboxymethylguanine. Removal of acyclovir is carried out both by glomerular filtration and by tubular secretion.
  In patients with chronic renal failure, the mean half-life during hemodialysis is 5.7 hours. During hemodialysis, plasma levels of acyclovir fall by approximately 60%. With limited renal function and creatinine clearance of 10 ml / min / 1.73 m2, there is a risk of cumulation at a dosage of 200 mg 5 times a day. Therefore, with the above creatinine clearance, a dose reduction is indicated.
  Pharmacodynamics
  Acyclovir is a synthetic analogue of a purine nucleoside that has the ability to inhibit in vitro and in vivo replication of human herpes viruses, including herpes simplex virus (HSV) types 1 and 2, varicella zoster virus and herpes zoster (VZV), Epstein-Barr virus (EBV) and cytomegalovirus (CMV). In cell culture, it has the most pronounced antiviral activity against HSV-1, followed in descending order of activity by: HSV-2, VZV, EBV and CMV. The action of acyclovir on herpes viruses (HSV-1,: HSV-2, VZV, EBV, CMV) is highly selective.
  Aciclovir is not a substrate for the thymidine kinase enzyme of non-infected cells, therefore it is not very toxic. Thymidine kinase of cells infected with HSV, VZV, EBV and CMV viruses converts acyclovir to acyclovir monophosphate, a nucleoside analog, which is then sequentially converted to diphosphate and triphosphate by cellular enzymes. The incorporation of acyclovir triphosphate into the viral DNA chain and subsequent chain termination block further viral DNA replication.
  In severely immunocompromised patients, prolonged or repeated courses of acyclovir therapy may lead to the formation of resistant strains, and therefore further treatment with acyclovir may not be effective. Most of the isolated strains with reduced sensitivity to acyclovir had a relatively low content of viral thymidine kinase, a violation of the structure of viral thymidine kinase or DNA polymerase. The impact of acyclovir on HSV strains in vitro can also lead to the formation of strains less sensitive to it. No correlation has been established between the sensitivity of HSV strains to ULCARIL® in vitro and the clinical efficacy of the drug.

  Indications for use
  – infections of the skin and mucous membranes caused by the herpes simplex virus
  , including primary and recurrent genital herpes
  – prevention of recurrence of infections caused by the herpes simplex virus
  in patients with a normal immune status and immunodeficiency
  – chickenpox smallpox, herpes zoster
  – Varicella zoster zoster
  Dosage and administration
  UCARIL® tablets can be taken with food, as eating does not significantly interfere with its absorption. The tablets should be taken with a full glass of water.
  Adults
  Treatment of infections caused by the herpes simplex virus
  For the treatment of infections caused by the herpes simplex virus, the recommended dose of the drug is 200 mg (1 tablet) 5 times a day every 4 hours, you can use a dose of 400 mg (1 tablet) 2 times a day day every 12 hours or 800 mg (1 tablet) 1 time per day, with the exception of the period of night sleep. The usual course of treatment is 5 days, but may be extended for severe primary infections.
  In case of severe immunodeficiency (for example, after bone marrow transplantation) or in violation of absorption from the intestine, the dose of the drug may be increased to 400 mg (1 tablet) 5 times a day. Treatment should begin as soon as possible after infection occurs. In case of relapses, it is recommended to prescribe the drug already in the prodromal period or when the first elements of the rash appear.
  Prevention of recurrence of infections caused by the herpes simplex virus with normal immune status
  For the prevention of recurrence of infections caused by the herpes simplex virus in patients with normal immunity, the recommended dose of the drug is 200 mg 4 times a day every 6 hours, or according to another treatment regimen – 400 mg 2 times a day every 12 hours or 800 mg 1 time per day. In some cases, lower doses of ULCARIL® 200 mg 3 times a day every 8 hours or 2 times a day every 12 hours are effective, or a single total daily dose of 800 mg (1 tablet) 1 time per day is possible.
  Treatment with the drug should be periodically interrupted for 6-12 months to identify possible changes in the course of the disease.
  Prevention of infections caused by herpes simplex virus in immunocompromised patients
  For the prevention of infections caused by herpes simplex virus in immunocompromised patients, the recommended dose of ULCARIL® is 200 mg 4 times a day every 6 hours or 400 mg 2 times a day every 12 hours. In case of severe immunodeficiency (for example, after bone marrow transplantation) or in case of impaired absorption from the intestine, the dose of ULCARIL® may be increased to 400 mg 5 times a day. The duration of the prophylactic course of therapy depends on the duration of the period of possible risk of infection.
  Treatment of chickenpox and herpes zoster
  For the treatment of chickenpox and herpes zoster, the recommended dose of ULCARIL® is 800 mg 5 times a day; the drug is taken every 4 hours, with the exception of the period of night sleep. The course of treatment is 7 days. Treatment with the drug should begin as soon as possible after the onset of infection, because. the effectiveness of the treatment depends on this.
  Children
  Tablets are not recommended for children under 6 years of age.
  Treatment of herpes simplex infections
  – children over 6 years old: 200 mg (1 tablet) 5 times a day every 4 hours, except during the night’s sleep. The course of treatment is 5 days.
  In case of severe immunodeficiency (eg, after bone marrow transplantation) or in violation of intestinal absorption, the dose may be increased to 400 mg 5 times a day.
  Prevention of infections caused by the herpes simplex virus in children with immunodeficiency
  – children over 6 years: 200 mg (1 tablet) 4 times a day every 6 hours.
  In case of severe immunodeficiency – 200 mg 5 times a day.
  Treatment of chickenpox
  – children over 6 years: 800 mg taken 4 times a day.
  A more accurate dose can be determined at the rate of 20 mg / kg body weight (but not more than 800 mg) 4 times a day. The course of treatment is 5 days.
  Prevention of recurrence of infections caused by the herpes simplex virus and treatment of herpes zoster in children with normal immunity
  Elderly patients
  In old age, acyclovir clearance in the body decreases in parallel with a decrease in creatinine clearance. Elderly patients should receive a sufficient amount of fluid while taking high doses of ULCARIL® orally, in case of renal insufficiency, they need to decide whether to reduce the dose of ULCARIL® to 200 mg (1 tablet) 2 times a day every 12 hours.
  Patients with renal insufficiency
  In patients with renal insufficiency, oral administration of ULCARIL® at the recommended doses for the treatment and prevention of infections caused by the herpes simplex virus does not lead to accumulation of the drug to concentrations exceeding the established safe levels. However, in patients with severe renal insufficiency (creatinine clearance less than 10 ml / min), the dose of ULCARIL® is recommended to be reduced to 200 mg (1 tablet) 2 times a day every 12 hours.
  In the treatment of chickenpox, herpes zoster, as well as in the treatment of patients with severe immunodeficiency, the recommended doses of ULCARIL® are:
  – severe renal failure (creatinine clearance <10 ml / min): 800 mg (4 tablets of 200 mg, or 2 tablets of 400 mg, or 1 tablet of 800 mg) 2 times a day every 12 hours;
  – moderate renal failure (creatinine clearance 10-25 ml / min): 800 mg (4 tablets of 200 mg, or 2 tablets of 400 mg, or 1 tablet of 800 mg) 3 times a day every 8 hours.

  Side effects 1,000), very rare (˂1/10,000). These side effects are expressed mainly in patients with renal insufficiency.
  Common
  Headache, dizziness
  Nausea, vomiting, diarrhea, abdominal pain
  Pruritus, rash, photosensitivity
  Fatigue, fever
  Uncommon
  Urticaria, rapid diffuse hair loss (associated with ULCARIL® not proven, more often associated with multiple variations in the course of the disease and a large number of drugs used)
  Rare
  – shortness of breath
  – angioedema
  – reversible increase in bilirubin and liver enzyme activity
  – increased concentration of urea and creatinine in the blood
  – anaphylaxis
  Very rarely
  – anemia, leukopenia and thrombocytopenia
  – hepatitis, jaundice
  – acute renal failure, renal pain
  – anxiety, confusion, tremor, ataxia, dysarthria, hallucinations, psychotic symptoms, convulsions, drowsiness, encephalopathy, coma (these symptoms are reversible and usually occur in patients with renal insufficiency or other predisposing factors).

  Contraindications
  – hypersensitivity to aciclovir or valaciclovir or other components of the drug
  – hereditary lactose intolerance or hereditary lactase deficiency, glucose / galactose malabsorption
  – children under 6 years of age
  UCARIL® should be used with caution in dehydration and renal failure.

  Drug Interactions
  No clinically significant drug interactions have been reported with UCARIL®.
  UCARIL® is excreted unchanged in the urine by active tubular secretion. All drugs with a similar route of elimination can increase the plasma concentration of acyclovir. Acyclovir enhances the effect of nephrotoxic drugs (especially in patients with impaired renal function).
  Cimetidine, being an inhibitor of microsomal oxidation, increases the AUC (area under the plasma concentration-time curve) of acyclovir, reduces its renal clearance and increases plasma concentration. There was an increase in plasma AUC for aciclovir and the inactive metabolite of mycophenolate mofetil, an immunosuppressant used in transplantation, with the simultaneous use of both drugs. However, dose adjustment is not required due to the wide range of therapeutic doses of UCARIL®.
  When prescribing UCARIL® 1 hour after taking 1 g of probenecid, the half-life of acyclovir and the area under the plasma concentration-time curve increased by 18 and 40%, respectively. Probenecid blocks the tubular secretion of acyclovir and thereby increases the concentration of acyclovir in blood plasma, cerebrospinal fluid and its half-life.
  Co-administration of acyclovir and zidovudine in HIV-infected patients does not affect the kinetics of these drugs.
  Acyclovir enhances the effect of aminobenzoic acid.
  Co-administration of acyclovir and ganciclovir increases (mutually) the risk of toxicity.
  Concomitant use of tacrolimus with acyclovir may increase the organotoxicity of the latter.
  Tacrolimus is unstable in an alkaline environment, so co-administration of tacrolimus reconstituted infusion concentrate (5 mg/mL) with acyclovir, which substantially alkalinizes the solution, should be avoided.
  Co-administration with cyclosporine may increase blood levels, increase (mutually) the risk of impaired renal function.

  Special instructions
  Patients taking high doses of UCARIL® by mouth should receive sufficient fluids.
  Long-term and repeated treatment with UCARIL in immunocompromised patients may lead to the development of resistance.
  When used simultaneously with nephrotoxic drugs in patients with impaired renal function and insufficient water load, the possibility of developing acute renal failure due to the formation of a precipitate from acyclovir crystals should be considered.
  When using ULCARIL®, it is necessary to monitor kidney function. Treatment of elderly patients should be carried out with a sufficient increase in water load and under medical supervision, because. in this category of patients, the half-life of acyclovir increases.
  Contraindicated in individuals with hereditary fructose intolerance, Lapp-lactase deficiency, glucose-galactose malabsorption.
  If women with genital herpes do not improve within 1 week
  , a gynecological examination should be performed. Patients with genital herpes have an increased risk of developing cervical cancer, so a Papanicolaou test should be performed once a year to determine the initial changes in the cervix. UCARIL® does not prevent sexual transmission of herpes, therefore, during the treatment period, it is necessary to refrain from sexual intercourse, even in the absence of clinical manifestations.
  Pregnancy and lactation
  An analysis of UCARIL® treatment of women during pregnancy did not reveal an increase in the number of birth defects in their children compared with the general population. However, caution should be exercised when prescribing ULCARIL® to women during pregnancy and assess the intended benefit to the mother and the possible risk to the fetus.
  Acyclovir passes into breast milk. After taking UCARIL® orally at a dose of 200 mg (1 tablet) 5 times a day, acyclovir was determined in breast milk at concentrations of 0. 6-4.1 of plasma concentrations. At these concentrations, breastfeeding children can receive acyclovir at a dose of up to 0.3 mg / kg / day. Given this fact, you should stop breastfeeding.
  Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
  Considering the side effects of the drug, care must be taken when driving vehicles or potentially dangerous mechanisms.

  Overdose
  Symptoms: after taking a single dose not exceeding 20 g of acyclovir, no toxic effects were observed. Multiple overdose of acyclovir over several days has resulted in gastrointestinal symptoms such as nausea and vomiting, as well as neurological symptoms such as headache and confusion.
  Treatment: symptomatic. If an overdose is suspected, the patient should be monitored for toxic symptoms. Dialysis is recommended, especially in patients with acute renal failure. It is necessary to increase the flow of fluid into the body to prevent the formation of crystals in the renal tubules.