What are the key ingredients in Alka-Seltzer Plus Cold Formula. How does this medication work to relieve cold symptoms. What are the potential side effects and precautions associated with Alka-Seltzer Plus Cold Formula. When should you seek medical attention while using this medication.

Understanding Alka-Seltzer Plus Cold Formula: Composition and Purpose

Alka-Seltzer Plus Cold Formula is a combination medication designed to provide relief from various symptoms associated with the common cold, flu, allergies, and other respiratory illnesses. This over-the-counter remedy contains three primary active ingredients: aspirin, chlorpheniramine, and phenylephrine. Each component plays a specific role in addressing different aspects of cold and flu symptoms.

• Aspirin: Acts as a pain reliever and fever reducer
• Chlorpheniramine: An antihistamine that helps alleviate allergy-related symptoms
• Phenylephrine: A decongestant that aids in relieving nasal congestion

The combination of these ingredients aims to provide comprehensive relief from multiple cold and flu symptoms simultaneously. However, it’s crucial to understand both the benefits and potential risks associated with this medication.

How Does Alka-Seltzer Plus Cold Formula Work?

The efficacy of Alka-Seltzer Plus Cold Formula lies in the synergistic action of its components. Each ingredient targets specific symptoms commonly associated with colds and flu:

1. Aspirin reduces fever and alleviates pain, including headaches and body aches.
2. Chlorpheniramine blocks histamine receptors, helping to reduce sneezing, runny nose, and watery eyes.
3. Phenylephrine constricts blood vessels in the nasal passages, decreasing congestion and improving breathing.

This multi-faceted approach allows users to experience relief from various symptoms with a single medication. However, it’s important to note that while these ingredients can provide symptom relief, they do not cure the underlying cold or flu virus.

Common Side Effects and Precautions

While Alka-Seltzer Plus Cold Formula can be effective in managing cold and flu symptoms, it’s essential to be aware of potential side effects and take necessary precautions. Some common side effects may include:

• Drowsiness or dizziness
• Dry mouth, nose, or throat
• Stomach upset or nausea
• Nervousness or restlessness
• Increased heart rate

Can Alka-Seltzer Plus Cold Formula cause serious side effects? In some cases, yes. More severe side effects, although rare, may occur and require immediate medical attention. These can include:

• Allergic reactions (rash, itching, swelling)
• Difficulty breathing or swallowing
• Unusual bleeding or bruising
• Persistent headache or fever
• Signs of liver problems (yellowing of eyes/skin, dark urine)

It’s crucial to follow the recommended dosage and consult a healthcare professional if symptoms persist or worsen.

Dosage Guidelines and Administration

Proper administration of Alka-Seltzer Plus Cold Formula is essential for both effectiveness and safety. The typical dosage for adults and children 12 years and older is:

• 2 tablets dissolved in 4 ounces of water
• Taken every 4 hours as needed
• Do not exceed 8 tablets in 24 hours

How should Alka-Seltzer Plus Cold Formula be taken? Always dissolve the tablets completely in water before consuming. This effervescent formulation allows for quick absorption and onset of action. It’s advisable to take the medication with food or milk if stomach upset occurs.

Is it safe to use Alka-Seltzer Plus Cold Formula for extended periods? Generally, this medication is intended for short-term use. If symptoms persist for more than 7 days or are accompanied by a high fever, consult a healthcare provider.

Drug Interactions and Contraindications

Alka-Seltzer Plus Cold Formula can interact with various medications and medical conditions. It’s crucial to be aware of potential interactions to avoid adverse effects. Some key considerations include:

• Avoid using with other medications containing aspirin or NSAIDs
• Use caution if taking blood thinners or have a bleeding disorder
• Consult a doctor before use if you have high blood pressure, heart disease, diabetes, or liver problems
• Avoid alcohol consumption while taking this medication

Does Alka-Seltzer Plus Cold Formula interact with common prescription medications? Yes, it can interact with several types of medications, including:

• Antidepressants (especially MAOIs)
• Blood pressure medications
• Anticoagulants
• Diabetes medications

Always inform your healthcare provider about all medications you’re taking, including over-the-counter products and supplements.

Special Considerations for At-Risk Groups

Certain populations need to exercise extra caution when considering the use of Alka-Seltzer Plus Cold Formula. These groups include:

Pregnant and Breastfeeding Women

Is Alka-Seltzer Plus Cold Formula safe during pregnancy and breastfeeding? The safety of this medication during pregnancy and lactation has not been firmly established. Pregnant women should consult their healthcare provider before use, as aspirin may pose risks to the developing fetus, particularly in the third trimester. Breastfeeding mothers should also seek medical advice, as components of the medication may pass into breast milk.

Elderly Individuals

Older adults may be more sensitive to the effects of Alka-Seltzer Plus Cold Formula, particularly the drowsiness caused by chlorpheniramine. They may also be at increased risk for side effects related to aspirin and phenylephrine. Dosage adjustments may be necessary, and close monitoring is advised.

Children

This medication is not recommended for children under 12 years of age without specific direction from a healthcare provider. The safety and efficacy in this age group have not been well-established, and there may be risks associated with certain ingredients, particularly aspirin.

Alternatives and Complementary Approaches

While Alka-Seltzer Plus Cold Formula can be effective, some individuals may prefer alternative approaches to managing cold and flu symptoms. Some options include:

• Natural remedies (e.g., honey, ginger, elderberry)
• Nasal irrigation with saline solution
• Humidifiers to moisturize the air
• Rest and increased fluid intake
• Individual symptom-specific medications (e.g., separate pain relievers, decongestants)

Are there non-medicinal approaches to managing cold symptoms? Yes, several lifestyle modifications and home remedies can help alleviate symptoms:

• Adequate rest and sleep
• Staying hydrated with water, herbal teas, and clear broths
• Using steam inhalation to relieve congestion
• Gargling with salt water for sore throat relief
• Maintaining good hand hygiene to prevent spread of infection

These approaches can be used alone or in conjunction with over-the-counter medications, depending on individual needs and preferences.

When to Seek Medical Attention

While Alka-Seltzer Plus Cold Formula can effectively manage many cold and flu symptoms, certain situations warrant professional medical attention. Be alert for the following signs:

• Fever above 103°F (39.4°C) or lasting more than three days
• Severe headache or neck stiffness
• Persistent vomiting
• Difficulty breathing or chest pain
• Symptoms lasting more than 10 days or worsening over time

How can you differentiate between a common cold and a more serious condition? While colds typically resolve on their own within a week to 10 days, certain symptoms may indicate a more severe illness:

• Severe sinus pain or headache
• Earache or drainage from the ear
• Shortness of breath or wheezing
• Cough producing thick, colored mucus
• Extreme fatigue or weakness

If you experience any of these symptoms or are unsure about the severity of your condition, it’s best to consult a healthcare professional for proper evaluation and treatment.

Understanding the proper use, potential side effects, and limitations of Alka-Seltzer Plus Cold Formula is crucial for safe and effective symptom management. While this medication can provide relief for many individuals suffering from colds and flu, it’s important to use it responsibly and be aware of when additional medical care may be necessary. Always follow the recommended dosage, be mindful of potential drug interactions, and don’t hesitate to seek professional advice if symptoms persist or worsen. By taking a balanced approach to cold and flu management, combining over-the-counter remedies with lifestyle modifications and proper self-care, you can effectively navigate the discomfort of these common ailments and support your body’s natural healing processes.

Alka-Seltzer Plus Cold/Cough (PSE) Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

One ingredient in this product is acetaminophen. Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.

Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.

Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine.

Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.

Warnings:

One ingredient in this product is acetaminophen. Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.

Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.

Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine.

Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.

… Show More

Uses

This combination medication is used to temporarily treat symptoms caused by the common cold, flu, allergies, or other breathing illnesses (such as sinusitis, bronchitis). Dextromethorphan is a cough suppressant that affects a certain part of the brain, reducing the urge to cough. Decongestants help relieve stuffy nose and ear congestion symptoms. Acetaminophen (APAP) is a non-aspirin pain reliever and fever reducer. Antihistamines help relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.This medication is not usually used for ongoing coughs from smoking, asthma, or other long-term breathing problems (such as emphysema), or for coughs with a lot of mucus, unless directed by your doctor.Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

How to use Alka-Seltzer Plus C/C (PSE) Capsule

See also Warning section.

If you are taking the over-the-counter product, read and follow all directions on the package label. If your doctor has prescribed this medication for you, take as directed by your doctor. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food or as directed by your doctor. If stomach upset occurs, it may help to take this medication with food or milk. Drink plenty of fluids when you use this medication unless otherwise directed by your doctor. The fluid will help loosen the mucus in your lungs.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.

If you are taking extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are taking the chewable form of this medication, chew it thoroughly before swallowing.

The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose, take it more often, or use it for a longer time than directed. Improper use of this medication (abuse) may result in serious harm (including brain damage, seizure, death).

Tell your doctor if your condition lasts for more than 1 week, if it gets worse, or if it occurs with a headache that doesn’t go away, rash, or fever lasting more than 3 days. These may be symptoms of a serious medical problem and should be checked by a doctor.

Side Effects

See also Warning section.

Drowsiness, dizziness, blurred vision, upset stomach, nausea, nervousness, constipation, or dry mouth/nose/throat may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as confusion, hallucinations), shaking, trouble urinating, fast/slow/irregular heartbeat, seizure.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Warning section.

Before taking this product, tell your doctor or pharmacist if you are allergic to any of its ingredients; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have any of the following health problems, consult your doctor or pharmacist before using this medication: breathing problems (such as asthma, emphysema), diabetes, glaucoma, heart problems, high blood pressure, kidney problems, liver disease, seizures, stomach/intestinal problems (such as blockage, constipation, ulcers), overactive thyroid (hyperthyroidism), urination problems (such as trouble urinating due to enlarged prostate, urinary retention).

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Some brands of this product may contain sugar, alcohol, or aspartame. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the effects of this drug, especially dizziness, drowsiness, mental/mood changes, constipation, trouble urinating, fast heartbeat, and blood pressure changes. Dizziness, drowsiness and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication may pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also Warning section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Taking certain MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

Some products that may interact with this drug are: antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), ketoconazole, levoketoconazole, rolapitant.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine).

The ingredients in this product are available in many prescription and nonprescription products. Check the labels on all your medicines (such as pain/fever drugs, diet aids, or cough-and-cold/allergy products) because they may contain the same or similar ingredients. Using these drugs along with this product could increase side effects (such as fast heartbeat, increased blood pressure, or drowsiness). Ask your pharmacist about using those products safely.

This medication may interfere with certain lab tests (such as urine drug screening tests, urine 5-HIAA), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Alka-Seltzer Plus C/C (PSE) Capsule interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, agitation, confusion, flushing, hallucinations, yellowing eyes/skin, dark urine, seizures. In children, excitement may occur first, and may be followed by: loss of coordination, drowsiness, loss of consciousness, seizures.

Keep all medical and lab appointments.

Do not take this product for several days before allergy testing because test results can be affected.

If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze liquid forms of this medication. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Drug Survey

Have you ever purchased Alka-Seltzer Plus C/C (PSE) Capsule?

Yes, In the past 3 months

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This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Alka-seltzer original

What is Alka-Seltzer original used for?

• Relieving mild to moderate pain including rheumatic and muscular pain, sprains and strains, backache, nerve pain (neuralgia), migraine, headache, toothache, sore throat, period pain.
• Lowering a high temperature (fever).
• Relieving symptoms of colds and flu.

How does Alka-Seltzer original work?

Alka-Seltzer original effervescent tablets contain three active ingredients, aspirin, sodium hydrogen carbonate and citric acid.

Aspirin belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of an enzyme in the body called cyclo-oxygenase (COX).

COX is involved in making substances in the body known as prostaglandins, in response to injury and in certain conditions. The prostaglandins cause pain, swelling and inflammation. Aspirin reduces inflammation and pain by reducing the production of these prostaglandins.

Aspirin brings down a fever by reducing the production of prostaglandins in the brain. Fever is associated with an increase in prostaglandins in the brain, which cause the body temperature to increase.

The sodium hydrogen carbonate and citric acid react with water to make a fizzy solution that is quickly absorbed into the bloodstream.

How do I take Alka-Seltzer original?

• Alka-Seltzer tablets should be dissolved in a glass of water before taking.
• Adults aged 16 years and over should take two tablets every four to six hours as needed. Do not take more than eight tablets in 24 hours.
• If symptoms persist despite treatment, get medical advice from your doctor or pharmacist.
• Do not use Alka-Seltzer for more than three days except on medical advice.

Who shouldn’t take Alka-Seltzer original?

• Children and adolescents under 16 years of age, unless on the advice of a doctor.
• People allergic to any ingredient of the medicine (always check the packet for the inactive ingredients of the medicine if you know you have specific allergies).
• People who have ever had an allergic reaction after taking ibuprofen or other NSAIDs such as diclofenac (for example an asthma attack, itchy rash, nasal inflammation (rhinitis) or swelling of the lips, tongue and throat).
• People with an active peptic ulcer, perforation (hole) or bleeding in the gut, or a history of these problems.
• People with blood clotting disorders such as haemophilia.
• Women who are breastfeeding.
• Women in the third trimester of pregnancy.
• People taking 15mg or more of methotrexate weekly.

Who should get medical advice before taking Alka-Seltzer original?

• People who suffer from asthma.
• People with a history of disorders affecting the stomach or intestines.
• People with kidney or liver problems.
• People with heart disease or high blood pressure.
• People taking anticoagulant or ‘blood thinning’ medicines.
• People who are just about to have or have recently had surgery.
• People who suffer from gout.
• People on a sodium-restricted diet.
• People with an enzyme deficiency called G6PD deficiency.

Can I take Alka-Seltzer original while pregnant or breastfeeding?

• Alka-Seltzer original should not be taken by women in the third trimester of pregnancy. If aspirin is used in the third trimester it may delay labour, increase the length of labour, increase the risk of bleeding in the mother and baby and cause complications in the newborn baby. Get medical advice from your doctor before taking Alka-Seltzer during any other stage of pregnancy.
• Alka-Seltzer original should not be taken by breastfeeding mothers because aspirin passes into breast milk and may be harmful to the nursing infant. Ask your pharmacist for advice on what medicines you can take if you’re breastfeeding.

What are the possible side effects of Alka-Seltzer original?

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with Alka-Seltzer. Just because a side effect is stated here doesn’t mean that all people using this medicine will experience that or any side effect.

• Disturbances of the gut such as nausea, vomiting, diarrhoea or abdominal pain. This can be helped by taking Alka-Seltzer with or after food.
• Ulceration or bleeding in the stomach or intestine. Stop taking Alka-Seltzer and consult your doctor immediately if you get any sign of bleeding from your stomach or bowels while taking it, for example vomiting blood and/or passing black/tarry/bloodstained stools.
• Changes in liver function.
• Increased time taken to stop bleeding.
• Allergic reactions such as skin rashes, swelling of the lips, tongue and throat (angioedema) or narrowing of the airways (bronchospasm). Get immediate medical advice if you think you’ve had an allergic reaction to Alka-Seltzer.

Read the leaflet provided with Alka-Seltzer or consult your doctor or pharmacist if you want any more information about possible side effects. If you think you have experienced a side effect, did you know you can report this using the yellow card website?

Can I take Alka-Seltzer original with other medicines?

If you’re already taking any medicines it’s best to check with your pharmacist before taking Alka-Seltzer as well, to make sure that the combination is safe.

Don’t take Alka-Seltzer with anti-inflammatory painkillers (NSAIDs) such as ibuprofen, diclofenac or naproxen, because this increases the chance of getting side effects on the gut. People taking selective inhibitors of COX-2 such as celecoxib or etoricoxib should avoid taking Alka-Seltzer for the same reason.

It’s fine to take Alka-Seltzer with paracetamol. You can also take it alongside opioid-type painkillers such as codeine, co-codamol, tramadol or morphine.

You’re more at risk of ulceration or bleeding in your gut if you take Alka-Seltzer with corticosteroids such as prednisolone. There may also be an increased risk of bleeding in the gut if you take Alka-Seltzer with other medicines that can increase the risk of bleeding, such as those below. If you’re taking one of these you shouldn’t take Alka-Seltzer unless you’ve checked with your pharmacist first:

• anti-blood-clotting (anticoagulant) medicines such as warfarin, dabigatran, apixaban, edoxaban, rivaroxaban, heparin and low molecular weight heparins such as enoxaparin
• antiplatelet medicines to reduce the risk of blood clots or ‘thin the blood’, eg dipyridamole, clopidogrel, prasugrel, low-dose aspirin
• erlotinib
• ginko biloba (a herbal remedy)
• iloprost
• SSRI antidepressants, eg fluoxetine, paroxetine, citalopram
• venlafaxine.

Don’t take Alka-Seltzer if you’re taking the medicine methotrexate, because aspirin can reduce the removal of methotrexate from the body and increase its side effects. The two should not usually be used together, unless on the advice of a doctor.

There may be an increased risk of side effects if aspirin is taken with acetazolamide.

Last updated 07.12.2016

Alka-Seltzer: instructions, reviews, analogues, price in pharmacies

1. 3 How do you rate the effectiveness of Alka-Seltzer?

   ☆ ☆ ☆ ☆ ☆

   • Pharmacological properties
   • Indications for use
   • Method of application
   • Contraindications
   • Side effects
   • Special instructions
   • Interactions
   • Overdose
   • Storage conditions

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   Pharmacological properties

   Alka-Seltzer 9004 6 – a combined preparation, the action of which is due to its active components.

   Acetylsalicylic acid has an analgesic, antipyretic, anti-inflammatory effect, which is due to the inhibition of cyclooxygenase enzymes involved in the synthesis of prostaglandins.

   Acetylsalicylic acid inhibits platelet aggregation by blocking the synthesis of thromboxane A2. 2 Sodium bicarbonate neutralizes free hydrochloric acid in the stomach, which reduces the irritant effect of the drug.

   Citric acid promotes faster absorption of the drug.

   Pharmacokinetics

   After oral administration, ASA is rapidly and completely absorbed from the gastrointestinal tract. During absorption and immediately after it, ASA turns into the main active metabolite – salicylic acid.

   ASA reaches its maximum plasma concentration after 10-20 minutes, and salicylic acid – after 0.3-2 hours. About 80% of ASA and salicylic acid binds to plasma proteins and is rapidly distributed in tissues.

   Salicylic acid is metabolized in the liver with the formation of metabolites – salicylurate, salicylic phenolic glucuronide, salicylacyl glucuronide, gentisic and gentisuric acids. It is excreted in breast milk and crosses the placenta. The elimination of salicylic acid is dose-dependent.

   The half-life varies from 2-3 hours at low doses to approximately 15 hours at high doses.

   Salicylic acid and its metabolites are excreted primarily by the kidneys.

   Indications for use

   It is prescribed for moderate pain syndromes of various origins (headache, toothache, back pain, menstrual pain), fever, hangover.

   How to use

   Dosage and duration of treatment is determined by the doctor. Recommended dose: for adults 1-3 tablets every 4-8 hours (maximum dose – 12 tablets), for children over 7 years old – 1 tablet no more than 3 times a day. Duration of treatment – 3 days. Use with caution in children.

   Contraindications

   Individual sensitivity to the components of the drug, hemorrhagic diathesis, peptic ulcer of the stomach and / or duodenum, as well as erosive and ulcerative lesions of the gastrointestinal tract in history, decompensated disorders of the kidneys and / or liver, the last trimester of pregnancy.

   Side effects

   Anorexia, nausea, vomiting, diarrhea, epigastric pain. Sometimes with frequent and prolonged use of the drug, erosive and ulcerative lesions of the gastrointestinal tract are possible. Allergic reactions. In single reviews on the use of Alka-Seltser, a violation of the function of the liver, kidneys, as well as a decrease in blood sugar levels were noted. Cancellation of the drug leads to the disappearance of side effects.

   Special instructions

   When the drug is used together Alka-Seltser with acetylsalicylic acid, there is an increase in the effect of non-steroidal anti-inflammatory drugs, anticoagulants, oral antidiabetic agents, groups of sulfonylurea derivatives, methotrexate, sulfonamides and their combinations, as well as an increase in the concentration of digoxin, barbiturates and lithium in the blood plasma.

   Interactions

   With the combined use of acetylsalicylic acid, an increase in the pharmacological effects of drugs such as anticoagulants, nonsteroidal anti-inflammatory drugs, oral antidiabetic drugs, groups of sulfonylurea derivatives, methotrexate, sulfonamides and their combinations, as well as an increase in the concentration of digoxin, barbiturates and lithium in blood plasma . With the simultaneous use of alcohol or use with steroid hormones synthesized by the adrenal cortex, the risk of developing gastrointestinal bleeding increases. The combined use of drugs that reduce the acidity of gastric contents by neutralizing or adsorbing gastric hydrochloric acid can lead to a decrease in the level of salicylates in the blood plasma.

   Overdose

   Gastrointestinal reactions, in children and the elderly dizziness, tinnitus, decreased visual acuity and hearing.

   Storage conditions

   Store in a dark place at room temperature.

   Basic parameters

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   Alcohol poisoning Hangover syndrome Hangover Alcohol intoxication Analgesics Painkillers

   Alkoseltzer (Alka-Seltzer) for hangover. Compound. How to use?

   This site is made by experts: toxicologists, narcologists, hepatologists. Strictly scientific. It is checked up experimentally.

   The author of this article, expert: toxicologist, candidate of sciences Stanislav Radchenko

   In short: Alkoseltzer consists of aspirin, baking soda and citric acid. Aspirin helps to cope with the symptoms of a hangover, it is better to take it even before the feast. Baking soda helps balance the acid-base balance. Two tablets dissolved in water should be taken at bedtime – and two can be taken in the morning.

   • Alka-Seltzer composition
   • How the drug works
   • Instruction. How to take Alka-Seltzer
   • Contraindications
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   Composition of Alka-Seltzer

   Alka-Seltzer (popularly: Alko-Seltzer, in the original: Alka-Seltzer) – perhaps the most famous anti-hangover remedy in the world, has been produced by Bayer since the thirties of the last century. It consists of:

   • aspirin (acetylsalicylic acid),
   • sodium bicarbonate (baking soda)
   • and citric acid.

   Alka-Seltzer makes you feel better when you have a hangover, and it is even better to take it in advance.

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   Since June 2012, the drug has been produced in a new package (pictured). Its composition and action remained unchanged.

   How the drug works

   Aspirin has an analgesic effect on a hangover (the manufacturer honestly reports this in the instructions) by suppressing the synthesis of prostaglandins. But this is a fight against the symptoms, not the root causes of a hangover. Also, acetylsalicylic acid breaks down erythrocyte microclots that form when alcohol is taken, which cause headache and swelling. In this sense, taking aspirin is much more effective, but mainly when taken in advance, that is, as a hangover prevention.

   Baking soda helps balance the acid-base balance in the body. It also neutralizes free hydrochloric acid in the stomach, which reduces the harm from aspirin, which is part of Alkoseltzer. When the drug tablet is dissolved in water, soda in combination with citric acid gives a violent reaction, which leads to the formation of bubbles. Carbonation gives a tonic effect and increases the bioavailability of the components of the drug.

   Alka-Seltzer is positioned not only as a remedy for a hangover, but also for headaches and heartburn.

   Recently, Bayer has been promoting a special version of the drug in the West called “Wake-up Call” , designed to relieve hangover symptoms. It contains caffeine in addition to aspirin. This tool has not yet been officially supplied to the Russian market.

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   Manual. How to take Alka-Seltzer

   Bayer recommends taking two tablets dissolved in a glass of water before going to bed, then the sensations and condition in the morning promise to be much better. In the morning, if you still feel unwell, you should also take two tablets.

   Dissolve effervescent tablets in a glass of water (200 ml) before use. The duration of treatment with the drug should not exceed 3 days. The maximum daily dose is 9 tablets. Between doses of the drug you need to take a break of at least 4 hours.

   Contraindications

   When should Alka-Seltzer not be taken? Like any other drug, this drug has contraindications:

   1. Erosions and ulcers of the stomach, intestines. The fact is that Alka-Seltzer contains aspirin. With a hangover, it helps to cope with swelling and headaches. But aspirin increases the risk of a variety of bleeding. Therefore, Alka-Seltzer should not be taken by those who at least occasionally have any bleeding.
   2. Any tendency to bleed.
   3. Hypersensitivity to aspirin and other non-steroidal anti-inflammatory drugs.
   4. Aspirin-dependent asthma.
   5. Pregnancy and lactation.
   6. Children under 15 with ARVI.
   7. Mettrexate treatment (aspirin is not well compatible with this drug).

   In addition, the instructions say that Alka-Seltzer should be taken with caution:

   1. When taking drugs that thin the blood (anticoagulants). This is due, again, to the possibility of bleeding. Therefore, it is better not to take risks.
   2. For liver, kidney and heart failure.
   3. For gout.
   4. With deficiency of glucose-6-phosphate dehydrogenase. Read interesting and funny articles in our blog!
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      Our readers share their experience of using the drug. Reviews for alkoseltzer are very different, from enthusiastic to negative:

      It helps me a lot!!! two pills… it was like yesterday!!! user of the site hangover.rf

      Complete zero, drank before bed and in the morning, the head didn’t even go away, don’t take another user of the site hangover.rf

      heavy:

      Alkoselzer doesn’t seem to help me with a drunken hangover… it helps if you start drinking in the evening and add it before going to bed or in the morning. current then the effect is! with a severe hangover, current time or a dropper helps site visitor hangover.rf

      I tried it – complete nonsense, maybe for girls, or for those who drink a bottle of beer – considers it a booze – that helps. But with a serious hangover – what to drink it, what to listen to the radio – the result is the same. reader site hangover.rf

      In addition, there are suggestions to independently assemble an anti-hangover remedy based on the composition of Alka-Seltser:

      It helps a little, only if you drink a little. But a good breakfast will help here. Given that the ingredients are known, the question is: why buy it at all? Aspirin, soda, and vitamin C alone are much cheaper. user of the site hangover.rf

      What science says

      In 1983, the scientist S. Kaivola and co-authors, based on the assumption that part of the symptoms of a hangover is due to inflammation, using tolfenamic acid as an example, reported on the effectiveness of non-steroidal anti-inflammatory drugs in alleviating hangover symptoms with a double prophylactic intake (shortly before drinking and at night).