What are the key facts about amoxicillin 250 mg capsules. How should amoxicillin be taken for optimal effectiveness. What are the common and serious side effects of amoxicillin. Who can safely take amoxicillin and who should avoid it.

Understanding Amoxicillin: A Powerful Antibiotic for Bacterial Infections

Amoxicillin is a versatile penicillin antibiotic widely prescribed for various bacterial infections. This medication plays a crucial role in modern healthcare, offering effective treatment for conditions ranging from common respiratory infections to more severe bacterial invasions.

What is Amoxicillin Used For?

Amoxicillin is primarily used to combat bacterial infections in different parts of the body. Its applications include:

• Treating chest infections, including pneumonia
• Addressing dental abscesses
• Combating ear infections in children
• Tackling stomach ulcers (in combination with other medications)

Is amoxicillin effective against all types of infections? No, it’s important to note that amoxicillin is specifically designed to target bacterial infections. It is not effective against viral infections such as the common cold or flu.

Amoxicillin 250 mg Capsule: Dosage and Administration

The typical dosage for amoxicillin capsules ranges from 250mg to 500mg, taken three times a day. However, the exact dosage may vary depending on the severity of the infection and the patient’s age and health status.

How Should Amoxicillin Be Taken?

To ensure maximum efficacy, follow these guidelines when taking amoxicillin:

1. Space doses evenly throughout the day
2. Take the medication before or after food
3. Swallow capsules whole with water
4. Complete the entire prescribed course, even if symptoms improve

Can amoxicillin be taken with food? Yes, amoxicillin can be taken either before or after meals. This flexibility makes it easier for patients to incorporate the medication into their daily routines.

Side Effects of Amoxicillin: What to Watch For

While amoxicillin is generally well-tolerated, it can cause side effects in some individuals. Understanding these potential reactions is crucial for patients and caregivers.

Common Side Effects

The most frequently reported side effects of amoxicillin include:

• Nausea
• Diarrhea

These side effects typically affect around 1 in 10 people. While they may be uncomfortable, they often do not require discontinuation of the medication. However, if these symptoms persist or worsen, consulting a healthcare provider is advisable.

Serious Side Effects

Although rare, serious side effects can occur in less than 1 in 1,000 people taking amoxicillin. These may include:

• Severe diarrhea containing blood or mucus
• Signs of liver or gallbladder problems
• Unexplained bruising or skin color changes
• Joint or muscle pain developing after 2 days of treatment
• Skin rash with circular red patches

Do serious side effects always appear immediately? No, it’s important to be aware that some serious side effects can manifest up to 2 months after completing the amoxicillin treatment course.

Allergic Reactions to Amoxicillin: Recognizing the Signs

Allergic reactions to amoxicillin occur in approximately 1 in 15 people. While most allergic responses are mild, manifesting as skin rashes treatable with antihistamines, severe allergic reactions can occur in rare cases.

Symptoms of a Serious Allergic Reaction

Patients should seek immediate medical attention if they experience:

• Wheezing or difficulty breathing
• Swelling of the face, lips, tongue, or throat
• Severe dizziness or fainting
• Rapid heartbeat

How quickly can an allergic reaction to amoxicillin develop? Allergic reactions can occur within minutes of taking the medication or may develop over several days. It’s crucial to remain vigilant throughout the course of treatment.

Who Can Safely Take Amoxicillin?

While amoxicillin is suitable for most adults and children, certain individuals should exercise caution or avoid the medication altogether.

Contraindications and Precautions

Before starting amoxicillin treatment, inform your healthcare provider if you:

• Have a history of allergic reactions to amoxicillin, penicillin, or other medications
• Suffer from liver or kidney problems
• Have recently received or are scheduled for any vaccinations
• Are pregnant or breastfeeding

Can individuals with a penicillin allergy take amoxicillin? Generally, people with known penicillin allergies should avoid amoxicillin due to the risk of cross-reactivity. However, in some cases, healthcare providers may perform allergy testing to determine if amoxicillin can be safely administered.

Amoxicillin and Lifestyle Considerations

Understanding how amoxicillin interacts with daily life can help patients manage their treatment more effectively.

Alcohol Consumption

Unlike some antibiotics, amoxicillin does not interact adversely with alcohol. However, it’s generally advisable to limit alcohol intake while fighting an infection to support the body’s healing process.

Dental Hygiene

Liquid forms of amoxicillin can temporarily stain teeth. This discoloration is not permanent and can be removed through regular brushing. Maintaining good oral hygiene during treatment is important to prevent this cosmetic issue.

Thrush Risk

Amoxicillin can sometimes lead to the development of thrush, a fungal infection. To minimize this risk, consider the following preventive measures:

• Practice good oral hygiene
• Rinse your mouth after using inhaled corticosteroids
• Consume probiotic-rich foods or supplements

Does thrush always occur with amoxicillin use? No, thrush is not an inevitable consequence of amoxicillin treatment. However, being aware of the possibility and taking preventive steps can help reduce the risk.

Amoxicillin in Pediatric Care: Special Considerations

Amoxicillin is frequently prescribed for children, particularly for ear infections and chest infections. However, dosing and administration for pediatric patients require special attention.

Dosage for Children

Pediatric dosages of amoxicillin are typically lower than adult doses and are calculated based on the child’s weight. Liquid formulations are available in 125mg and 250mg concentrations to facilitate accurate dosing for children.

Administration Tips for Parents

When giving amoxicillin to children, consider the following guidelines:

• Use the provided measuring device (syringe or spoon) for accurate dosing
• Shake liquid formulations well before each use
• If your child has difficulty swallowing capsules, consult your healthcare provider about liquid alternatives
• Ensure your child completes the entire prescribed course, even if symptoms improve

Can amoxicillin be mixed with food or drinks to improve palatability for children? While mixing amoxicillin with a small amount of food or drink is generally acceptable, it’s crucial to ensure the entire dose is consumed. Always consult with your healthcare provider or pharmacist before altering the medication’s administration method.

Maximizing the Effectiveness of Amoxicillin Treatment

To ensure the best possible outcomes when using amoxicillin, patients should adhere to certain best practices throughout their treatment course.

Completing the Full Course

One of the most critical aspects of antibiotic treatment is completing the entire prescribed course, even if symptoms improve before the medication is finished. This practice helps prevent the development of antibiotic-resistant bacteria.

Managing Missed Doses

If a dose is missed, take it as soon as you remember. However, if it’s almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Never double up on doses to make up for a missed one.

Monitoring for Improvement

While taking amoxicillin, patients should monitor their symptoms and overall health. If there’s no improvement after a few days of treatment, or if symptoms worsen, it’s essential to contact a healthcare provider for further evaluation.

How long does it typically take for amoxicillin to start working? Most patients begin to feel better within a few days of starting amoxicillin treatment. However, the exact timeline can vary depending on the type and severity of the infection being treated.

Amoxicillin and Antibiotic Resistance: A Growing Concern

The rise of antibiotic-resistant bacteria is a significant global health concern, and the responsible use of antibiotics like amoxicillin plays a crucial role in addressing this issue.

Contributing Factors to Antibiotic Resistance

Several factors contribute to the development of antibiotic resistance:

• Overuse of antibiotics for viral infections
• Incomplete antibiotic courses
• Use of antibiotics in livestock
• Poor infection control practices in healthcare settings

Preventing Antibiotic Resistance

Patients can help combat antibiotic resistance by:

1. Only taking antibiotics when prescribed by a healthcare professional
2. Completing the full course of antibiotics as directed
3. Not sharing antibiotics with others or using leftover antibiotics
4. Practicing good hygiene to prevent the spread of infections

Can individual actions really make a difference in the fight against antibiotic resistance? Yes, while antibiotic resistance is a complex global issue, individual actions collectively contribute to slowing its progression. Every responsible use of antibiotics helps preserve their effectiveness for future generations.

Drug Interactions with Amoxicillin: What Patients Should Know

Understanding potential drug interactions is crucial for patients taking amoxicillin to ensure safe and effective treatment.

Common Interactions

Amoxicillin may interact with several medications and substances, including:

• Methotrexate: Amoxicillin can increase methotrexate levels in the blood
• Probenecid: This medication can increase amoxicillin levels in the body
• Oral contraceptives: Amoxicillin may reduce the effectiveness of birth control pills
• Warfarin: Amoxicillin can potentially increase the anticoagulant effect of warfarin

Herbal Supplements and Amoxicillin

Some herbal supplements may also interact with amoxicillin. It’s important to inform your healthcare provider about all medications, vitamins, and supplements you’re taking before starting amoxicillin treatment.

Should patients stop taking their regular medications when prescribed amoxicillin? No, patients should not discontinue any regular medications without consulting their healthcare provider. Instead, inform your doctor about all current medications to allow for appropriate adjustments or monitoring.

Amoxicillin Storage and Disposal: Ensuring Safety and Efficacy

Proper storage and disposal of amoxicillin are essential for maintaining its effectiveness and preventing accidental ingestion or environmental contamination.

Storage Guidelines

To preserve the potency of amoxicillin:

• Store capsules at room temperature, away from heat and moisture
• Keep liquid formulations refrigerated and use within 14 days
• Protect the medication from direct sunlight
• Keep out of reach of children and pets

Safe Disposal Methods

When disposing of unused or expired amoxicillin:

1. Check for local medication take-back programs
2. Mix the medication with an undesirable substance (e.g., used coffee grounds) and place in a sealed container before disposing in household trash
3. Remove or obscure personal information on the prescription label

Can expired amoxicillin be safely used? No, using expired amoxicillin is not recommended. The medication may lose its potency over time, potentially leading to ineffective treatment or unexpected side effects. Always check the expiration date before use and properly dispose of expired medications.

Future Developments in Antibiotic Treatment: Beyond Amoxicillin

While amoxicillin remains a cornerstone of antibiotic therapy, ongoing research is paving the way for new treatment options and approaches to combat bacterial infections.

Emerging Antibiotics

Scientists are continually working to develop new classes of antibiotics to address the growing threat of antibiotic resistance. Some promising areas of research include:

• Teixobactin: A novel antibiotic that targets cell wall synthesis in bacteria
• Bacteriophage therapy: Using viruses that infect bacteria as a treatment option
• CRISPR-Cas9 technology: Exploring gene-editing techniques to combat antibiotic-resistant bacteria

Personalized Antibiotic Therapy

Advancements in diagnostic technologies are enabling more targeted antibiotic treatments. Rapid bacterial identification and antibiotic susceptibility testing allow healthcare providers to prescribe the most effective antibiotic for each patient’s specific infection.

Will new antibiotics completely replace amoxicillin in the future? While new antibiotics will likely play an increasingly important role in treating bacterial infections, established antibiotics like amoxicillin are expected to remain valuable treatment options. The goal is to expand the arsenal of effective antibiotics while preserving the usefulness of existing medications through responsible use.

Amoxicillin: antibiotic to treat bacterial infections

1. About amoxicillin

Amoxicillin is a penicillin antibiotic. It is used to treat bacterial infections, such as chest infections (including pneumonia) and dental abscesses. It can also be used together with other antibiotics and medicines to treat stomach ulcers.

It’s often prescribed for children, to treat ear infections and chest infections.

Amoxicillin is only available on prescription. It comes as capsules or as a liquid that you swallow. It’s also given by injection, but this is usually only done in hospital.

2. Key facts

• For most infections, you’ll start to feel better in a few days.
• The most common side effects of amoxicillin are feeling sick (nausea) and diarrhoea.
• Liquid amoxicillin can stain your teeth. This does not last and is removed by brushing.
• You can drink alcohol while taking amoxicillin.
• Sometimes, taking amoxicillin can cause thrush.

3. Who can and cannot take amoxicillin

Amoxicillin can be taken by most adults and children.

Find out more about giving amoxicillin to children on the Medicines for Children website.

Amoxicillin is not suitable for everyone. To make sure amoxicillin is safe for you, tell your doctor if you:

• have ever had an allergic reaction to amoxicillin or penicillin or any other medicine
• have liver or kidney problems
• have recently had, or are due to have, any vaccinations

4. How and when to take amoxicillin

Dosage

The usual dose of amoxicillin capsules is 250mg to 500mg, taken 3 times a day. The dose may be lower for children.

Amoxicillin liquid is available in 125mg and 250mg doses.

Important

Carry on taking this medicine until you’ve completed the course, even if you feel better. If you stop your treatment early, the infection could come back.

How to take it

Try to space the doses evenly throughout the day. If you take it 3 times a day, this could be first thing in the morning, mid-afternoon and at bedtime.

You can take amoxicillin before or after food.

Swallow amoxicillin capsules whole with a drink of water. Do not chew or break them.

Amoxicillin is available as a liquid for children and people who find it difficult to swallow capsules.

If you or your child are taking liquid amoxicillin, it will usually be made up for you by your pharmacist. The medicine will come with a plastic syringe or spoon to help you measure out the right dose. If you do not have one, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not measure the right amount.

If you forget to take it

If you forget to take a dose, take it as soon as you remember, unless it’s nearly time for your next dose. In this case, just leave out the missed dose and take your next dose at the usual time.

Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to remember your medicines.

If you take too much

Taking an extra dose of amoxicillin is unlikely to harm you or your child, but speak to your pharmacist or doctor if you’re worried.

Urgent advice: Contact 111 for advice now if:

You have taken more than your prescribed dose of amoxicillin and have symptoms including:

• stomach pain or you’re being sick
• blood in your pee
• difficulty peeing or producing less pee than usual

Go to 111.nhs.uk or call 111

5. Side effects

Like all medicines, amoxicillin can cause side effects, although not everyone gets them.

Common side effects

These common side effects happen in around 1 in 10 people. Keep taking the medicine, but talk to your doctor or pharmacist if these side effects bother you or do not go away:

• feeling sick (nausea)
• diarrhoea

Serious side effects

Serious side effects are rare and happen in less than 1 in 1,000 people.

Call a doctor or call 111 now if you get:

• diarrhoea (possibly with stomach cramps) that contains blood or mucus or severe diarrhoea that lasts for more than 4 days
• pale poo and dark pee, and the whites of your eyes or your skin turn yellow (although this may be less obvious on brown or black skin) – these can be signs of liver or gallbladder problems
• bruising or changes in your skin colour
• joint or muscle pain that comes on after 2 days of taking the medicine
• a skin rash with circular red patches (this may be less obvious on brown or black skin)

Some of these serious side effects can happen up to 2 months after finishing the amoxicillin.

Serious allergic reaction

Around 1 in 15 people have an allergic reaction to amoxicillin.

In most cases, the allergic reaction is mild and can take the form of a skin rash.

Mild skin rashes can usually be treated by taking antihistamines.

In rare cases, amoxicillin can cause a serious allergic reaction (anaphylaxis).

Immediate action required: Call 999 now if:

• your lips, mouth, throat or tongue suddenly become swollen
• you’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
• your throat feels tight or you’re struggling to swallow
• your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
• you suddenly become very confused, drowsy or dizzy
• someone faints and cannot be woken up
• a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who’s unwell may also have a rash that’s swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of amoxicillin. For a full list, see the leaflet inside your medicines packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

6. How to cope with side effects of amoxicillin

What to do about:

• feeling sick – stick to simple meals and do not eat rich or spicy food. It might help to take your amoxicillin after a meal or snack.
• diarrhoea – drink plenty of fluids, such as water or squash, to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor. If you take contraception and you have severe diarrhoea for more than 24 hours, your contraceptive pills may not protect you from pregnancy. Check the pill packet to find out what to do.

7. Pregnancy and breastfeeding

Amoxicillin and pregnancy

It is safe to take amoxicillin during pregnancy.

Amoxicillin and breastfeeding

It is OK to take amoxicillin while breastfeeding. Information shows that only tiny amounts of amoxicillin get into breast milk. Such levels would not be expected to cause side effects in your baby.

Talk to your doctor, pharmacist, health visitor or midwife if:

• your baby is not feeding as well as usual
• they have sickness or diarrhoea
• your baby has oral thrush, or a skin rash
• you have any other concerns about your baby

For more information about how amoxicillin can affect you and your baby during pregnancy, visit the Best Use of Medicines in Pregnancy (BUMPS) website.

8. Cautions with other medicines

There are some medicines that do not mix well with amoxicillin.

Tell your doctor if you’re taking any of these medicines before you start taking amoxicillin:

• methotrexate, used to treat arthritis and psoriasis
• warfarin, a medicine to prevent blood clots
• gout medicines called probenecid or allopurinol
• other antibiotics

Tell your doctor if you’ve recently had, or are due to have, an oral typhoid vaccine. Amoxicillin can make it less effective.

Mixing amoxicillin with herbal remedies and supplements

There is little information about taking herbal remedies and supplements alongside amoxicillin.

Important:
Medicine safety

Tell your doctor or pharmacist if you’re taking any other medicines, including herbal medicines, vitamins or supplements.

9. Common questions about amoxicillin

How does amoxicillin work?

Amoxicillin is a penicillin antibiotic. It works by killing the bacteria that cause the infection.

When will I feel better?

For most infections, you should feel better within a few days.

It’s very important that you keep taking amoxicillin until your course is finished. Do this even if you feel better. It will help stop the infection coming back.

What if I do not get better?

Tell your doctor if you do not start feeling better after taking amoxicillin for 3 days. Also tell them if, at any time, you start to feel worse.

Will it give me thrush?

Some people get a fungal infection called thrush after taking a course of antibiotics like amoxicillin. If you think you have thrush, speak to your pharmacist or ask your doctor for advice.

How does amoxicillin compare with other antibiotics?

Amoxicillin and other penicillins, like phenoxymethylpenicillin, are antibiotics that are widely used to treat a variety of infections, including skin, dental, throat and chest infections.

Not all antibiotics are suitable for every infection. Your doctor will choose an antibiotic that’s suitable for the type of infection you have. Speak to your pharmacist or doctor if you have any questions.

Will it affect my contraception?

Amoxicillin does not stop contraceptive pills working, including the combined pill or emergency contraception.

However, if amoxicillin makes you sick (vomit) or have severe diarrhoea for more than 24 hours, your contraceptive pills may not protect you from pregnancy. Check the pill packet to find out what to do.

Find about more about what to do if you’re on the pill and you’re being sick or have diarrhoea.

Will it affect my fertility?

There’s no evidence to suggest that taking amoxicillin reduces fertility in either men or women.

Does it stain teeth?

If you or your child take amoxicillin as a liquid medicine, it can stain your teeth. This does not last and should go after brushing your teeth well.

Amoxicillin capsules do not stain teeth.

Can I drive or ride a bike?

Yes. Amoxicillin should not affect you being able to drive or cycle.

Is there any food or drink I need to avoid?

You can eat and drink normally while taking amoxicillin.

Can I drink alcohol with it?

Yes, you can drink alcohol with amoxicillin.

AMOXYCILLIN 250MG CAPSULES BP | Drugs.com

Active substance(s): AMOXYCILLIN TRIHYDRATE

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24 mm

AMOXICILLIN 250mg CAPSULES
AMOXICILLIN 500mg CAPSULES
Read all of this leaflet carefully before you start taking this medicine.
Even if you have used this medicine or a similar product before, you
should read this text carefully as the information may have changed.
• Keep this leaflet. You may need to read it again.
• If you have any further queries, ask your doctor or pharmacist.
• This medicine has been prescribed for you only. Do not pass it on to
others. It may harm them, even if their symptoms are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 4.
In this leaflet:
1. What this medicine is and what it is used for
2. What you need to know before you take this medicine
3. How to take this medicine
4. Possible Side Effects
5. How to store this medicine.
6. Contents of the pack and other information

1. What this medicine is and what it is used for
What Amoxicillin is
Amoxicillin is an antibiotic. The active ingredient is amoxicillin. This belongs
to a group of medicines called ‘penicillins’.
What Amoxicillin is used for
Amoxicillin is used to treat infections caused by bacteria in different parts of
the body. Amoxicillin may also be used in combination with other medicines
to treat stomach ulcers.

2. What you need to know before you take this medicine
Do not take this medicine if you:
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– if you are allergic to amoxicillin, penicillin or any of the other ingredients of
this medicine (listed in section 6).
– if you have ever had an allergic reaction to any antibiotic. This can include
a skin rash or swelling of the face or throat.
Warnings and Precautions
Talk to your doctor or pharmacist before taking this medicine if you:
• have glandular fever (fever, sore throat, swollen glands and extreme
tiredness)
• have kidney problems
• are not urinating regularly.
If you are not sure if any of the above apply to you, talk to your doctor or
pharmacist before taking Amoxicillin.
Blood and urine tests
If you are having:
• Urine tests (glucose) or blood tests for liver function
• Oestriol tests (used during pregnancy to check the baby is developing
normally)
Tell your doctor or pharmacist that you are taking Amoxicillin This is because
Amoxicillin can affect the results of these tests.
Other medicines and Amoxicillin
Tell your doctor or pharmacist if you are taking, have recently taken or might
take any other medicines.
• If you are taking allopurinol (used for gout) with Amoxicillin, it may be
more likely that you will have an allergic skin reaction.
• If you are taking probenecid (used for gout), your doctor may decide to
adjust your dose of Amoxicillin.
• If you are taking medicines to help stop blood clots (such as warfarin), you
may need extra blood tests.
• If you are taking other antibiotics (such as tetracycline) Amoxicillin may
be less effective.
• If you are taking methotrexate (used for the treatment of cancer and severe
psoriasis) Amoxicillin may cause an increase in side effects.

Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are
planning to have a baby, ask your doctor or pharmacist for advice before
taking this medicine.
Driving and using machines
Amoxicillin can have side effects and the symptoms (such as allergic
reactions, dizziness and convulsions) may make you unfit to drive.
Do not drive or operate machinery unless you are feeling well.
Important information about some of the ingredients of these
capsules
• The colours sunset yellow (E 110) and carmoisine (E 122) in the
capsule shell can cause allergic type reactions.
• This medicine also contains Methylparaben(E218) and Propylparaben
(E216) which may cause allergic reactions.

3.How to take this medicine
Always take this medicine exactly as your doctor or pharmacist has told
you. Check with your doctor or pharmacist if you are not sure.
• Swallow with water without opening capsule.
• Space the doses evenly during the day, at least 4 hours apart.
The usual dose is:
Children weighing less than 40 kg
All doses are worked out depending on the child’s body weight in kilograms.
• Your doctor will advise you how much Amoxicillin you should give to
your baby or child.
• The usual dose is 40 mg to 90 mg for each kilogram of body weight a day,
given in two or three divided doses.
• The maximum recommended dose is 100 mg for each kilogram of body
weight a day.
Adults, elderly patients and children weighing 40 kg or more
The usual dose of Amoxicillin is 250 mg to 500 mg three times a day or 750
mg to 1 g every 12 hours, depending on the severity and type of infection.

• Severe infections: 750 mg to 1 g three times a day.
• Urinary tract infection: 3 g twice daily for one day.
• Lyme disease (an infection spread by parasites called ticks): Isolated
erythema migrans (early stage – red or pink circular rash): 4 g a day,
Systemic manifestations (late stage – for more serious symptoms or
when the disease spreads around your body): up to 6 g a day.
• Stomach ulcers: one 750 mg or one 1 g dose twice a day for 7 days with
other antibiotics and medicines to treat stomach ulcers.
• To prevent heart infection during surgery: the dose will vary according
to the type of surgery. Other medicines may also be given at the same
time. Your doctor, pharmacist or nurse can give you more details.
• The maximum recommended dose is 6 g per day.
Kidney problems
If you have kidney problems the dose might be lower than the usual dose.
If you take more Amoxicillin than you should
If you have taken too much Amoxicillin, signs might be an upset stomach
(feeling sick, being sick or diarrhoea) or crystals in the urine, which may be
seen as cloudy urine, or problems urinating. Talk to your doctor as soon as
possible. Take the medicine to show the doctor.
If you forget to take Amoxicillin
• If you forget to take a dose, take it as soon as you remember.
• Do not take the next dose too soon, wait about 4 hours before taking the
next dose.
• Do not take a double dose to make up for a forgotten dose.
How long should you take Amoxicillin for?
• Keep taking Amoxicillin for as long as your doctor has told you to, even
if you feel better. You need every dose to help fight the infection. If some
bacteria survive they can cause the infection to come back.
• Once you finish treatment, if you still feel unwell you should go back to
see the doctor.
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•
•
•
•
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kidney problems
fits (convulsions), seen in patients on high doses or with kidney problems
dizziness
hyperactivity
crystals in the urine, which may be seen as cloudy urine, or difficulty or
discomfort in passing urine. Make sure you drink plenty of fluids to reduce
the chance of these symptoms
• the tongue may change to yellow, brown or black and it may have a hairy
appearance
• an excessive breakdown of red blood cells causing a type of anaemia.
Signs include: tiredness, headaches, shortness of breath, dizziness,
looking pale and yellowing of the skin and the whites of the eyes
• low number of white blood cells
• low number of cells involved with blood clotting
• the blood may take longer to clot than it normally would. You may notice
this if you have a nosebleed or cut yourself.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also report
side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/
yellowcard. By reporting side effects you can help provide more information
on the safety of this medicine.

5. How to store this medicine
• Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated on the
carton. The expiry date refers to the last day of that month.
• Do not store above 25oC.
• Do not use this medicine if there are visible signs of deterioration.
• Do not throw away any medicines via wastewater or household waste.
Ask your pharmacist how to throw away medicines you no longer use.
These measures will help protect the environment.

6. Contents of the pack and other information
What Amoxicillin Capsules contain:
• The active substance is Amoxicillin Trihydrate. The active substance in
each capsule is 250 mg or 500 mg amoxicillin.
• The other ingredient of the powder is magnesium stearate
• The capsule shell for both strengths contains gelatin, sunset yellow
(E 110), carmoisine (E 122), brilliant blue (E 133),quinoline yellow (E 104),
titanium dioxide (E171), Methyl hydroxybenzoate (E218) and Propyl
hydroxybenzoate (E216).
What Amoxicillin Capsules look like and contents of the pack:
• Amoxicillin 250mg Capsules -Red/buff coloured, hard gelatin capsule
containing a white to off white powder. Printed with ‘’AMOXY 250’’.
• Amoxicillin 500mg Capsules -Red/buff coloured, hard gelatin capsule
containing a white to off white powder. Printed with ‘’AMOXY 500’’
• Amoxicillin Capsules are supplied to your pharmacist in packs containing
21, 100, 250, 500 and 1000 capsules.
• Not all pack sizes may be marketed.
Marketing Authorisation Holder and Manufacturer
Name and address:
Bristol Laboratories Ltd,
Unit 3, Canalside, Northbridge Road, Berkhamsted,
Hertfordshire, United Kingdom, HP4 1EG
Telephone: 0044 (0) 1442 200922
Fax:
0044 (0) 1442 873717
Email:
[email protected]
Amoxicillin 250mg Capsules; PL 17907/0006
Amoxicillin 500mg Capsules; PL 17907/0007
This leaflet was last revised in March 2016
To request a copy of this leaflet in Braille, large print or audio format, please
contact the licence holder at the address (or telephone, fax, email) above.
V8 05-03-2016 D0

120 mm

4. Possible Side Effects
Like all medicines, this medicine may sometimes cause side effects, although
not everybody gets them.
Stop taking Amoxicillin and see a doctor straight away, if you notice
any of the following serious side effects – you may need urgent
medical treatment:
The following are very rare (affects less than 1 in 10,000 people)
• allergic reaction, the signs include: skin rash or itching, swelling of the
face, lips, tongue, body or breathing difficulties.These can be serious and
occasionally deaths have occured
• rash or pinpoint flat red round spots under the skin surface or bruising of the
skin. This is due to inflammation of blood vessel walls due to an allergic
reaction. It can be associated with joint pain (arthritis) and kidney problems
• a delayed allergic reaction can occur usually 7 to 12 days after having
Amoxicillin, some signs include: rashes, fever, joint pains and enlargement
of the lymph nodes especially under the arms
• a skin reaction known as ‘erythema multiforme’ where you may develop:
itchy reddish purple patches on the skin especially on the palms of the
hands or soles of the feet, ‘hive-like’ raised swollen areas on the skin,
tender areas on the surfaces of the mouth, eyes and genitals. You may
have a fever and be very tired
• other severe skin reactions can include: changes in skin colour, bumps
under the skin, blistering, pustules, peeling, redness, pain, itching, scaling.
These may be associated with fever, headaches and body aches
• fever, chills, a sore throat or other signs of an infection, or if you bruise
easily. These may be signs of a problem with your blood cells

• the Jarisch-Herxheimer reaction which occurs during treatment with
Amoxicillin for Lyme disease and causes fever, chills, headache, muscle
pain and skin rash.
• inflammation of the large bowel (colon) with diarrhoea (sometimes containing
blood), pain and fever
• serious liver side effects may occur. They are mainly associated with
people having treatment over a long period, males and the elderly. You
must tell your doctor urgently if you get: o severe diarrhoea with bleeding
• blisters, redness or bruising of the skin
• darker urine or paler stools
• yellowing of the skin or the whites of the eyes (jaundice). See also
anaemia below which might result in jaundice.
These can happen when having the medicine or for up to several weeks
after.
If any of the above happen stop taking the medicine and see your
doctor straight away. Sometimes you may get less severe skin
reactions such as:
• a mildly itchy rash (round, pink-red patches), ‘hive-like’ swollen areas on
forearms, legs, palms, hands or feet. This is uncommon (may affect up to
1 in 100 people).
If you have any of these talk to your doctor as Amoxicillin will need
to be stopped.
The other possible side effects are:
Common (may affect up to 1 in 10 people)
• skin rash
• feeling sick (nausea)
• diarrhoea.
Uncommon (may affect up to 1 in 100 people)
• being sick (vomiting).
Very rare (may affects up to 1 in 10,000 people)
• thrush (a yeast infection of the vagina, mouth or skin folds), you can get
treatment for thrush from your doctor or pharmacist

xxxxxxx

Thrush (a yeast infection of moist areas of the body which can cause
soreness, itching and white discharge) may develop if Amoxicillin is used
for a long time. If this occurs tell your doctor.
If you take Amoxicillin for a long time, your doctor may perform additional
tests to check your kidneys, liver and blood are working normally.
If you have any further questions on the use of this medicine, ask your doctor
or pharmacist.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Amoxicillin capsules 250mg No. 16 (9 pieces) at a low price in Omsk, instructions for use, composition, analogues 010

Active ingredient :

Amoxicillin 250 mg (as trihydrate).

Excipients:

Magnesium stearate

Microcrystalline cellulose pH 102

250 mg capsule composition:

Titanium Dioxide E171

Quinoline Yellow E 104

Azorubine E 122

Patent Blue V E 131

Brilliant Black E 151

900 04 Gelatin

Pharmacological action

Amoxicillin – antibacterial acid-resistant bactericidal spectrum of action from the group of semi-synthetic penicillins.

Inhibits transpeptidase, disrupts the synthesis of peptidoglycan (supporting cell wall protein) during division and growth, causes bacterial lysis.

Due to the broad spectrum of action, the drug is active against both gram-positive and gram-negative microorganisms.

Clinically significant amoxicillin-susceptible Gram-negative organisms include Escherichia coli, Proteus mirabilis, Salmonella, Shigella, Campylobacter, Haemophilus influenzae, Bordetella pertussis, Leptospira, Chlamydia.

In addition, amoxicillin is active against all microorganisms sensitive to penicillin G, for example, streptococci of groups A, B, C, G, H, I, M, Streptococcus pneumoniae, staphylococci and Neisseria spp., not

penicillinase-producing, Erysipelothrix rhysiopathiae, Corynebacterium, Bacillus anthracis, Actinomycetes, Streptobacilli, Spirillium minus, Pastereulla multocida, Listeria, Spirochaeta (Leptospira, Treponema, Borrelia) and others,

as well as various anaerobic microorganisms (including peptococci, peptostreptococci , clostridia and fusobacteria).

Pharmacokinetics

Absorption – fast, high (93%), food intake does not affect absorption, is not destroyed in the acidic environment of the stomach.

When taken orally at a dose of 125 and 250 mg, the maximum concentration is 1.5-3 mcg / ml and 3.5-5 mcg / ml, respectively.

The action develops 15-30 minutes after application and lasts 8 hours. The time to reach the maximum concentration after oral administration is 1-2 hours.

It has a large volume of distribution – high concentrations are found in plasma, sputum, secret distribution is weak), pleural and peritoneal fluid, urine,

contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bone, adipose tissue, gallbladder (with normal liver function), fetal tissues.

Doubling the dose also doubles the concentration. The concentration in bile exceeds the concentration in plasma by 2-4 times.

In the amniotic fluid and umbilical cord vessels, the concentration of amoxicillin is 25-30% of the level in the plasma of a pregnant woman.

Poorly penetrates the blood-brain barrier, with inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%. Communication with plasma proteins – 17%.

Partially metabolized to inactive metabolites. The half-life is 1-1.5 hours.

Small amounts are excreted in breast milk. In case of impaired renal function (creatinine clearance less than or equal to 15 ml / min), the half-life increases to 8.5 hours.

Amoxicillin is removed by hemodialysis.

Active ingredients

Amoxicillin

Indications

Bacterial infections caused by susceptible microflora:

• respiratory and ENT infections (sinusitis, pharyngitis, tonsillitis, acute otitis media, bronchitis, pneumonia),
• genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis),
• gastrointestinal tract (peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis),
• skin and soft tissue infections (erysipelas, impetigo, secondarily infected dermatoses),
• leptospirosis,
• listeriosis,
• Lyme disease (borreliosis),
• dysentery, almonellosis,
• salmonellosis,
• meningitis,
• endocarditis (prophylaxis),
• sepsis.

Use in pregnancy and lactation

Amoxicillin may be used during pregnancy when the benefit to the mother outweighs the potential risk to the fetus.

Amoxicillin is excreted in breast milk in low concentrations.

If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Contraindications

• Hypersensitivity to the components of the drug (including other penicillins, cephalosporins, carbapenems),
• allergic diseases (including history),
• bronchial asthma, 900 94
• pollinosis,
• infectious mononucleosis,
• lymphocytic leukemia,
• liver failure,
• colitis associated with the use of antibiotics, including history,
• body less than 40 kg.

Precautions

Precautions – pregnancy, allergic reactions (including history), diseases of the gastrointestinal tract in history, renal failure, as well as indications of a history of bleeding.

Side effects

Allergic reactions:

skin rash, flushing, itching, urticaria, erythema, angioedema, rhinitis, conjunctivitis. fever, joint pain, eosinophilia, exfoliative dermatitis, exudative polyform

erythema, Stevens-Johnson syndrome. reactions similar to serum sickness, toxic epidermal necrolysis, generalized exanthematous pustulosis, allergic vasculitis, anaphylactic shock.

From the digestive system:

dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, abnormal liver function, moderate increase in liver transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, pseudomembranous colitis.

From the nervous system:

agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, convulsions.

Laboratory indicators:

leukopenia, neutropenia, thrombocytopenic purpura, anemia.

Other:

shortness of breath, tachycardia, interstitial nephritis, crystalluria, eosinophilia, agranulocytosis, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Interactions

Pharmaceutically incompatible with aminoglycosides (cannot be mixed to avoid mutual inactivation).

Antacids, glucosamine, laxatives, food, aminoglycosides – delay and reduce absorption. ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) – synergistic action. bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index). reduces the effectiveness of estrogen-containing oral contraceptives,

drugs, during the metabolism of which paraaminobenzoic acid is formed, ethinyl estradiol – the risk of breakthrough bleeding.

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs. drugs that block tubular secretion – reducing tubular secretion, increase the concentration.

Allopurinol increases the risk of skin rash.

Reduces clearance and increases methotrexate toxicity.

Increases the absorption of digoxin.

How to take, course of administration and dosage

Inside, before or after meals.

Adults and children over 10 years of age (weighing over 40 kg) are prescribed 500 mg 3 times a day. in severe infections – 750 mg – 1 g 3 times a day.

In acute uncomplicated gonorrhea, 3 g is given as a single dose. in the treatment of women, repeated administration of the indicated dose is recommended.

In acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, in gynecological infectious diseases for adults – 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

Adults with leptospirosis – 0.5-0.75 g 4 times a day for 6-12 days.

In case of salmonella carriage in adults – 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis in minor surgical interventions in adults – 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours.
In children, the dose is reduced by 2 times.

In patients with impaired renal function with creatinine clearance of 15-40 ml / min, the interval between doses is increased to 12 hours with creatinine clearance below 10 ml / min, the dose is reduced by 15-50%. with anuria – the maximum dose is 2 g / day.

Overdose

Symptoms: nausea, vomiting, diarrhea, water and electrolyte imbalance (as a result of vomiting and diarrhea).

Treatment: gastric lavage, activated charcoal, saline laxatives, drugs to maintain fluid and electrolyte balance. hemodialysis.

Indication

Antibiotic-penicillin

Special instructions

Special instructions

During course treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys. Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.

When administered to patients with bacteremia, a bacteriolysis reaction (Jarish-Herxheimer reaction) may develop.

In patients who are hypersensitive to penicillins, allergic cross-reactions with cephalosporin antibiotics are possible.

Antidiarrheal drugs that reduce intestinal motility should be avoided in the treatment of mild diarrhea during the course of treatment. kaolin- or attapulgite-containing antidiarrheals may be used. For severe diarrhea, see a doctor.

Treatment necessarily continues for another 48-72 hours after the disappearance of clinical signs of the disease.

When using estrogen-containing oral contraceptives and amoxicillin at the same time, other or additional methods of contraception should be used whenever possible.

Product form

Capsules

Storage conditions

In a dry, dark place at a temperature of 15 to 25 °C.

Keep out of reach of children.

Shelf life

3 years.