Amoxicillin 500 milligram. Amoxicillin 500mg: Comprehensive Guide to Conditions Treated and Usage
What conditions does Amoxicillin 500mg treat. How effective is Amoxicillin for various bacterial infections. What are the potential side effects of Amoxicillin 500mg. How should Amoxicillin be taken for optimal results.
Understanding Amoxicillin: A Versatile Antibiotic
Amoxicillin, a widely prescribed antibiotic, belongs to the penicillin family and is known for its broad-spectrum activity against various bacterial infections. The 500mg dosage is commonly used to treat a range of conditions, from respiratory infections to skin problems. But how exactly does this medication work, and what makes it so effective?
Amoxicillin functions by inhibiting the growth of bacteria by interfering with their cell wall synthesis. This mechanism allows it to combat a wide array of bacterial strains, making it a go-to choice for many healthcare providers. However, it’s crucial to understand that Amoxicillin is not effective against viral infections, such as the common cold or flu.
Key Features of Amoxicillin 500mg
- Broad-spectrum antibiotic
- Belongs to the penicillin class
- Available in various forms (capsules, tablets, liquid)
- Typically prescribed for 7-10 days
- Can be taken with or without food
Respiratory Tract Infections: Amoxicillin’s Primary Battlefield
Respiratory tract infections are among the most common reasons for prescribing Amoxicillin 500mg. These infections can affect various parts of the respiratory system, from the sinuses to the lungs. How effective is Amoxicillin in treating these conditions?
For acute bacterial sinusitis, Amoxicillin is often the first-line treatment. It’s particularly effective against Streptococcus pneumoniae and Haemophilus influenzae, two common culprits behind sinus infections. In cases of strep throat and tonsillitis, Amoxicillin has shown high efficacy rates, often resolving symptoms within a few days of starting treatment.
Respiratory Conditions Treated by Amoxicillin 500mg
- Acute bacterial sinusitis
- Strep throat and tonsillitis
- Bacterial pneumonia
- Chronic bronchitis (acute exacerbations)
- Lower respiratory tract infections
Is Amoxicillin effective for all types of pneumonia? While it’s highly effective against many strains of bacteria causing pneumonia, including Streptococcus pneumoniae and Haemophilus influenzae, some cases may require different antibiotics or combination therapy, especially if atypical pathogens are suspected.
Skin and Soft Tissue Infections: Amoxicillin’s External Battles
Skin and soft tissue infections represent another significant area where Amoxicillin 500mg proves its worth. These infections can range from superficial skin issues to more severe conditions affecting deeper tissues. How does Amoxicillin fare against these external invaders?
Amoxicillin is particularly effective against skin infections caused by Streptococcus bacteria, which are responsible for conditions like cellulitis and erysipelas. It’s also used to treat skin infections caused by certain strains of E. coli. In cases of more complex skin and soft tissue infections, Amoxicillin may be combined with other antibiotics for broader coverage.
Types of Skin Infections Treated by Amoxicillin
- Cellulitis
- Erysipelas
- Impetigo
- Skin abscesses (in combination with drainage)
- Wound infections
Can Amoxicillin treat all types of skin infections? While it’s effective against many common skin pathogens, some skin infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA), may not respond to Amoxicillin alone and may require alternative antibiotics.
Gastrointestinal and Genitourinary Infections: Internal Battles
Amoxicillin 500mg plays a crucial role in treating various internal infections, particularly those affecting the gastrointestinal and genitourinary systems. These infections can cause significant discomfort and, if left untreated, may lead to more severe complications. How effective is Amoxicillin in addressing these internal bacterial invasions?
In the gastrointestinal tract, Amoxicillin is notably effective against Helicobacter pylori, a bacterium responsible for many cases of gastritis and peptic ulcers. When used as part of a combination therapy, it significantly increases the chances of eradicating this persistent pathogen. For genitourinary infections, Amoxicillin shows efficacy against various strains of E. coli and Proteus, common culprits in urinary tract infections (UTIs).
Gastrointestinal and Genitourinary Conditions Treated
- H. pylori-associated gastritis and peptic ulcers
- Typhoid fever
- Urinary tract infections (uncomplicated)
- Bacterial prostatitis
- Gonorrhea (in combination with other antibiotics)
Does Amoxicillin work for all types of UTIs? While effective for many uncomplicated UTIs, some strains of bacteria have developed resistance to Amoxicillin. In such cases, alternative antibiotics may be necessary, highlighting the importance of proper diagnosis and antibiotic susceptibility testing.
Lyme Disease and Prophylaxis: Amoxicillin’s Preventive Role
Beyond treating active infections, Amoxicillin 500mg also plays a crucial role in preventing certain bacterial diseases and managing chronic conditions like Lyme disease. How effective is Amoxicillin in these preventive and long-term treatment scenarios?
For Lyme disease, Amoxicillin is one of the preferred treatments, especially for early-stage infections. Its ability to penetrate various tissues makes it effective against the Borrelia burgdorferi bacteria responsible for Lyme disease. In terms of prophylaxis, Amoxicillin is sometimes used to prevent bacterial endocarditis in high-risk patients undergoing certain dental or medical procedures.
Preventive and Long-term Uses of Amoxicillin
- Treatment of early-stage Lyme disease
- Prophylaxis for bacterial endocarditis
- Post-exposure prophylaxis for anthrax
- Prevention of recurrent UTIs in some cases
- Management of chronic bronchitis exacerbations
Is Amoxicillin always the best choice for Lyme disease? While effective for many cases, particularly in the early stages, some patients may require different antibiotics or combination therapies, especially in more advanced stages of the disease or in cases of persistent symptoms.
Dosage and Administration: Maximizing Amoxicillin’s Effectiveness
The proper dosage and administration of Amoxicillin 500mg are crucial for its effectiveness and to minimize the risk of side effects or antibiotic resistance. How should patients take Amoxicillin to ensure optimal results?
Typically, Amoxicillin 500mg is taken orally every 8 to 12 hours, or as prescribed by a healthcare provider. The duration of treatment usually ranges from 7 to 10 days, but this can vary depending on the severity and type of infection. It’s important to complete the entire course of antibiotics, even if symptoms improve before the medication is finished.
Key Points for Proper Amoxicillin Use
- Take at evenly spaced intervals to maintain consistent blood levels
- Can be taken with or without food
- Liquid forms should be shaken well before use
- Never skip doses or stop treatment early
- Store at room temperature, away from moisture and heat
Should Amoxicillin be taken with food? While it can be taken with or without food, some patients find that taking it with food helps reduce stomach upset. However, the absorption of Amoxicillin is not significantly affected by food intake.
Side Effects and Precautions: Navigating Potential Risks
While Amoxicillin 500mg is generally well-tolerated, it’s important to be aware of potential side effects and take necessary precautions. What are the most common side effects, and how can patients minimize their risk?
The most frequently reported side effects include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Allergic reactions, ranging from mild skin rashes to severe anaphylaxis, can occur, especially in individuals with a history of penicillin allergy. It’s crucial to inform healthcare providers of any allergies or medical conditions before starting Amoxicillin treatment.
Common Side Effects and Precautions
- Gastrointestinal disturbances (nausea, diarrhea)
- Skin rashes
- Yeast infections (oral or vaginal)
- Potential for antibiotic-associated diarrhea
- Risk of allergic reactions
Can Amoxicillin interact with other medications? Yes, Amoxicillin can interact with certain drugs, including birth control pills, blood thinners, and other antibiotics. It’s essential to disclose all medications, including over-the-counter drugs and supplements, to your healthcare provider before starting Amoxicillin treatment.
Antibiotic Resistance: A Growing Concern
The effectiveness of Amoxicillin 500mg, like all antibiotics, is increasingly challenged by the growing issue of antibiotic resistance. How does this impact the use of Amoxicillin, and what can be done to preserve its efficacy?
Antibiotic resistance occurs when bacteria evolve to survive the effects of antibiotics, making infections harder to treat. The overuse and misuse of antibiotics, including Amoxicillin, contribute to this problem. To combat resistance, healthcare providers are becoming more judicious in prescribing antibiotics, often reserving them for confirmed bacterial infections and using targeted therapies when possible.
Strategies to Combat Antibiotic Resistance
- Prescribing antibiotics only when necessary
- Using the correct antibiotic for the specific infection
- Completing the full course of antibiotics as prescribed
- Avoiding antibiotic use for viral infections
- Promoting proper hygiene to prevent infection spread
How can patients help prevent antibiotic resistance? Patients play a crucial role by taking antibiotics exactly as prescribed, not sharing antibiotics with others, and not using leftover antibiotics from previous treatments. Additionally, practicing good hygiene and getting vaccinated can help prevent infections and reduce the need for antibiotics.
Future of Amoxicillin: Innovations and Alternatives
As medical research advances, the future of Amoxicillin and antibiotic treatment continues to evolve. What innovations are on the horizon, and what alternatives are being developed to complement or replace traditional antibiotics like Amoxicillin?
Researchers are exploring various avenues to enhance the effectiveness of existing antibiotics and develop new treatment strategies. This includes combination therapies, novel drug delivery methods, and the development of new classes of antibiotics. Additionally, there’s growing interest in alternative approaches such as bacteriophage therapy and immunomodulatory treatments.
Emerging Trends in Antibiotic Treatment
- Development of new antibiotic classes
- Personalized antibiotic therapy based on genetic profiling
- Nanotechnology-based drug delivery systems
- Exploration of natural antimicrobial compounds
- Advancements in rapid diagnostic techniques
Will Amoxicillin remain a viable treatment option in the future? While antibiotic resistance poses challenges, ongoing research and responsible use practices aim to preserve the effectiveness of Amoxicillin and other antibiotics. The future likely holds a combination of improved traditional antibiotics and innovative treatment approaches.
Patient Experiences: Real-World Insights
Understanding patient experiences with Amoxicillin 500mg provides valuable insights into its real-world effectiveness and potential side effects. What do patients typically report about their experiences with this antibiotic?
Patient experiences with Amoxicillin vary widely. Many report rapid improvement of symptoms, particularly for respiratory and skin infections. However, some patients experience gastrointestinal side effects or allergic reactions. It’s important to note that individual responses can differ, and what works well for one person may not be as effective or well-tolerated by another.
Common Patient Observations
- Quick relief of symptoms for many infections
- Gastrointestinal discomfort in some cases
- Varied experiences with taste (especially liquid forms)
- Concerns about antibiotic resistance
- Importance of completing the full course
How can patients best manage potential side effects? Staying hydrated, taking probiotics, and communicating with healthcare providers about any adverse effects can help manage and mitigate potential side effects of Amoxicillin treatment.
Conditions that Amoxicillin Treats
- typhoid fever
- pediatric fever without a source
- inflammation of the stomach lining caused by H. pylori
- skin infection due to Streptococcus bacteria
- skin infection due to E. coli bacteria
- an infection of the skin and the tissue below the skin
- infection of genitals or urinary tract due to Enterococcus
- strep throat
- strep throat and tonsillitis
- a bacterial infection
- Lyme disease
- treatment to prevent anthrax after exposure to disease
- skin infection caused by anthrax
- a bacterial infection of the middle ear
- treatment to prevent bacterial infection of a heart valve
- acute bacterial infection of the sinuses
- acute sinusitis caused by Streptococcus pneumoniae
- acute sinusitis caused by Haemophilus influenzae
- throat irritation
- throat infection caused by Haemophilus influenzae
- infection of the throat caused by Staphylococcus bacteria
- infection of tonsils caused by Staphylococcus bacteria
- infection of the tonsils caused by Haemophilus influenzae
- bacterial pneumonia caused by Streptococcus pneumoniae
- bacterial pneumonia caused by Haemophilus influenzae
- bacterial pneumonia caused by Streptococcus
- bacterial infection with chronic bronchitis
- chronic bronchitis caused by Streptococcus pneumoniae
- chronic bronchitis caused by Haemophilus influenzae
- a lower respiratory infection
- ulcer of duodenum caused by bacteria Helicobacter pylori
- peptic ulcer due to bacteria Helicobacter pylori
- an infection of the genitals or urinary tract
- infection of genital and urinary tract due to E. coli
- infection of genitals or urinary tract due to Proteus
- a common cold
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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Most voted positive review
33 People found this comment helpful
Severe diarrhoea on completion of course. Never had diarrhoea like this before. Tongue now bright red and swollen. Salts and potassium levels very low in spite of fluids+. lips and mouth very dry. Loss of appetite. Dizziness and muscle weakness. Oh to feel better!
Most voted negative review
20 People found this comment helpful
I was prescribed this (generic version) for sinus infection. Completed 10 days of Novamoxin-Amoxicillin(3 tablets x 500 mg/day). 2 days later completing it, had a severe allergic reaction (bad hives, itching, rash). Went to emerg, it was that bad. Now day 9 after break-out: still itchy, but less (it’s migrating), rash is diminishing, but am advised it could take up to 6 weeks for these to go …
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Overall rating 1.0
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Took amoxycillin on two occasions to prevent infection following periodontal (gum) surgery. First time, no problem. Second time, had a rare reaction. Amoxycillin triggered aseptic meningitis that required 5 days in hospital followed by 2 weeks of rehab in a skilled nursing facility. Meningitis presented as a pulsating headache on first day of taking amoxycillin; on the third day the meningitis caused memory loss and inability to speak in sentences (a form of aphasia). After stopping the medication, some memory and speech capabilities returned each day, and recovery was complete after about a month. (No treatment is available for aseptic meningitis; patients recover on their own. My age–over 75–may have been a factor.)Read More Read Less
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Fill 3Created with Sketch. Condition: Acute Infection of the Nose, Throat or Sinus
Overall rating 2.0
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My infection has grown worse since starting the prescription 3-days ago.
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Fill 3Created with Sketch. Condition: infection caused by bacteria
Overall rating 1.0
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I was prescribed this for UTI for 7 days. I had no side effects whatsoever while taking it. A week or so after finishing it, my vagina started to itch and I had brown discharge. A few days later, the frequent urination started (I still have it, 3 months on!) together with very dark stools, which took 2 weeks to go back to normal. Amoxicillin must have depleted me of all the good bacteria. It dried me out! The UTI? I still have it now, after trying other antibiotics.
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Fill 3Created with Sketch. Condition: Throat Infection caused by Haemophilus Influenzae
Overall rating 2.0
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Chest infection,asthma,breathless,5 day amoxcillin,but after 3 more infection back
1
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Overall rating 5.0
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I have used this medication many times in my life, usually for strep throat or upper respiratory infections. When it works, it works fast and well. My most recent experience was with bronchitis that developed into a general UR infection that kept hanging on for a month, with a continuing cough, fever, and accompanying body aches that were unresponsive to anything but maximum doses of aspirin and codeine. Tests for influenza and covid-19 were repeatedly negative. Finally my PCP decided to try amoxicillin experimentally for a so-far unidentified bacterial infection. About a half hour after my first dose, my body aches vanished, my face was slightly flushed, and I felt so normal it was almost euphoric. This is the fastest response I can remember, though at least two other times when I had severe bacterial infections something similar happened after about an hour. I’ve never had any serious side effects. This drug works for me against bacteria, and when it turns out the infection was viral and the drug has no effect, I usually know that within a few hours of my first dose.Read More Read Less
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Fill 3Created with Sketch. Condition: infection caused by bacteria
Overall rating 1.0
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I used it for strapt throat and it gave me white spots in my mouth cut up my mouth and tongue, gave me a serve yeast infection. I will never use it again. Took it for 4 days 3 times a day. Lip n tongue was swollen. Still trying to feel better
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Fill 3Created with Sketch. Condition: Middle Ear Infection
Overall rating 3.7
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Has helped with ear pain/fullness- but not totally gone. It did make me have more frequent bowel movements, but nothing too crazy. Day four and there’s still some funk coming out of my ears and some muffled hearing. Hopefully by day 10 that will all be gone.
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Fill 3Created with Sketch. Condition: Acute Infection of the Nose, Throat or Sinus
Overall rating 2.3
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I have symptoms like swallowing difficulty, allergy and probably sinusitis which isn’t diagnosed as doctors say all normal.
ENT specialist prescribed this medicine along with pantoprazole. 1st day I took the Amoxicillin morning and night. Next day I helped with some household chores after taking the medicine in the morning but later in the afternoon my neck and shoulder area got so stiff along with numbness kind in arms and head felt like it is pulling itself upwards… Later on after an hour or so I was fine. After such an episode I stopped taking this medicine though the symptoms are still there.Read More Read Less
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Fill 3Created with Sketch. Condition: Strep Throat
Overall rating 5.0
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I didn’t really experience any of the side effects, but only within a day of using amoxicillin did my throat infection heal considerably. After the first day, it still hurt a little but, but on the second day after, it didn’t hurt at all. I barely noticed I was sick at all, only that I’m taking the rest of the pills as instructed by my doctor.
1
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Fill 3Created with Sketch. Condition: Other
Overall rating 2.3
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I have a SULFA allergy, and this contains sulfates. I had a major reaction in which the paramedics were called. I also had an EPI-PEN which stopped the reaction in less than 2 minutes. Know your allergies first, because the pharmacy missed mine.
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Fill 3Created with Sketch. Condition: Throat Irritation
Overall rating 2.3
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I’ve only been taking amoxicillin for one day and my heart rate has increased rapidly to the point where I thought I might have a heart attack.. definitely not sure how the next couple days are going to be or if I should keep taking it. My mom has taken it before and had no reaction and states that I’ve taken it a couple times in my childhood. Not sure if my heart rate issues are due to some underlying heart problems or not but I’m definitely skeptical about the side effects.. aside from that it almost instantly took the swelling away in my throat. I’ve been drinking plenty of water and staying hydrated. I’ve also got some unknown stomach issues that I’m hoping it will help with. I’m going to call my care provider for more advice but beware that if you have any underlying or unknown heart issues it might make it worse… my heart rate has been heavily elevated for about 5 hours now with no decrease at all. Read More Read Less
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Fill 3Created with Sketch. Condition: Throat Irritation
Overall rating 5.0
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Over all with my condition of throat with extreme soreness and to the point I could’ve lost my voice completely. I took the medicine but would miss doses and of course it got worse my doctor said if I didn’t take the medicine I my voice box that starts with a L but I can’t remember how to spell it. So I did what he said to do. I didn’t like the side effects mostly sweating but after 10 days of treatment my zthroat was healed. Had to drink lots of fluids and I believe it was the water that help mostly.. Back then my father had throat problems he was put on it and even now if I get a severe throat infection as my doctor for that medicine because it works the other side effect stay out of the sun. Maybe it works better for Throat infections. And I’m thankful for it very thankful for it. AnneRead More Read Less
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Fill 3Created with Sketch. Condition: Chronic Bronchitis caused by Streptococcus Pneumoniae
Overall rating 1.7
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As a teen I would be given penicillin for strep or sinus infections. When the trend grew away from penicillin, I was given Amoxicillin for a bronchial infection. After a few days I broke out with terrible hives. Gave me Erythromycin for the infection & antihistamine to relieve the itching. Today when asked what I’m allergic to & I state Amoxicillin – staff always tells me it’s the same as penicillin. I’ve read many sources explaining the differences that can cause the allergic reaction. Amoxicillin is laboratory (man made) and penicillin is natural. Read More Read Less
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Fill 3Created with Sketch. Condition: Infection of the Middle Ear caused by Streptococcus
Overall rating 2.3
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was given this for a severe ear infection to take 1 875mg pill 2x daily for 7 days then on day 4 I had a severe allergic reaction(red,itchy rash of the face, neck and chest)
1
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Fill 3Created with Sketch. Condition: Acute Bacterial Infection of the Sinuses
Overall rating 1.0
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I was given this as a result of a long term sinus infection. It is very hard to say whether the antibiotic worked or the sinus infection left on itâ??s own as the side effects were so horrendous. Severe nausea, retching and vomiting, itchiness, dizziness and vertigo, anxiety, disturbed sleep and severe tinnitus. Would never take again even if I was paid to.
2
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Fill 3Created with Sketch. Condition: infection caused by bacteria
Overall rating 2.3
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I was given 500mg tablets of this drug by my current dentist to help kill off bacteria under the gums that was causing an abscess. This drug while effective on killing the bacterial infection hasn’t been such a good trip in terms of side effects, as usual for me with any penicillin based drugs I end up getting dizzy to the point where I have to lay down, even if it means not being able to sleep… but I ended up getting new side effects from this, loose skin at the back of throat, which lead to breathing problems, biofilm on my tongue, a really huge sense of dread/anxiety, my tinnitus has increased ringing and most recently since three days ago, moderately strong heart palpations while laying down and attempting to fall asleep.Read More Read Less
1
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Fill 3Created with Sketch. Condition: Other
Overall rating 3.7
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Severe diarrhoea on completion of course. Never had diarrhoea like this before. Tongue now bright red and swollen. Salts and potassium levels very low in spite of fluids+. lips and mouth very dry. Loss of appetite. Dizziness and muscle weakness. Oh to feel better!
33
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Overall rating 5.0
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I was given Amoxicillin 500mg because I have a total knee replacement(2011)in my right knee, and I’m preparing to have the left total knee replacement in three weeks. And prior to the replacement I needed to have some dental work done and my Orthopaedic Surgeon requires a treatment of Amoxicillin prior to dental work and surgery. I have not experienced any of the listed side effects nor any other adverse effect. I was prescribed a 7 day dosage of 3 pills per day.
19
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Fill 3Created with Sketch. Condition: Infection of Genitals or Urinary Tract
Overall rating 4.7
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Starting taking this on a Monday and by Thurs was feeling much better. Dr said it would take awhile to work. Best thing was I didnt feel extremely nauseous or have diarrhea while on this. It did make me tired and was hard to swallow but would take this again.
2
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Fill 3Created with Sketch. Condition: Infection of the Throat caused by Staphylococcus Bacteria
Overall rating 2.7
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Was prescribed amoxicillin 550 for pharynitis for 10 days after taking it for 5 days noticed my lymph nodes swollen on my left side under my chin. Have some concern if this is normal.it. cleared my infection. But my neck and throat hurts like the sickens.
2
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Amoxicillin 150, 50 ml. ANTIBACTERIAL. veterinary preparations. Veterinary pharmacy “ZooPharm”
COMPOSITION AND FORM OF RELEASE
Long-acting antibacterial drug containing 150 mg of amoxicillin in the form of trihydrate and oily filler in 1 ml as an active ingredient. Produced in the form of a sterile white suspension for injection in dark glass bottles of 50 ml.
PHARMACOLOGICAL PROPERTIES
Amoxicillin is a semi-synthetic antibiotic from the penicillin group. Has a wide spectrum of bactericidal action against gram-positive (Actinomyces spp., Bacillus anthracis, Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Staphylococcus spp., Streptococcus spp.) and gram-negative microorganisms (Actinobacillus spp., Bordetella bronchiseptica, E coli, Salmonella spp., Fusobacterium spp., Haemophilus spp., Moraxella spp., Pasteurella spp., Proteus mirabilis). The drug does not act on penicillinase-forming strains of microorganisms from the genera Klebsiella and Enterobacter, as well as Pseudomonas. Amoxicillin interferes with the synthesis of the bacterial cell wall by inhibiting the enzymes transpeptidase and carboxypeptidase and causing osmotic imbalance, which leads to the death of the bacterium during the growth stage. The oily filler, which is part of the drug, gradually releases micronized amoxicillin into the blood, thereby providing a long-term effect of the antibiotic. When administered parenterally, amoxicillin is well absorbed into the blood from the injection site and rapidly distributed in the body, reaching the highest concentration in muscle tissue, liver, kidneys, gastrointestinal tract due to a slight connection with plasma proteins (17-20%). Amoxicillin penetrates the brain and bone fluid to a small extent, except when the meninges are inflamed. The maximum plasma concentration is reached within 1-2 hours after the administration of the drug and remains at a therapeutic level for 48 hours. Amoxicillin is practically not metabolized. Excreted from the body mainly with urine, to a lesser extent with milk and bile.
INDICATIONS
Indicated in cattle, sheep, goats, pigs, dogs and cats for the treatment of bacterial infections of the gastrointestinal tract (including enteritis, gastroenteritis, gastroenterocolitis), respiratory diseases (including bronchitis, bronchopneumonia, rhinitis), surgical diseases (including wounds, abscesses, inflammation of the joints), diseases of the genitourinary system (metritis, endometritis, cystitis, urethritis, pyelonephritis), diseases of the skin and soft tissues (including umbilical infections), as well as complications caused by microorganisms sensitive to amoxicillin. For the treatment of leptospirosis, mastitis, agalactia in pigs, actinomycosis, swine erysipelas, parainfluenza and paratyphoid.
DOSES AND METHOD OF APPLICATION
Amoxicillin is administered to animals intramuscularly or subcutaneously at a dose of 1 ml per 10 kg of animal weight (15 mg of active ingredient per 1 kg of body weight). For animals with renal insufficiency, it is recommended to accurately adjust the dose of the drug. Before use, the contents of the vial are thoroughly shaken until a homogeneous suspension is obtained. If necessary, it is possible to re-administer the drug after 48 hours. For the introduction of amoxicillin suspension, only dry sterile syringes and needles are used. If the administered dose of the drug exceeds 20 ml, it is recommended to administer it with several injections at different points. The injection site after the introduction of amoxicillin is recommended to be lightly massaged.
SIDE EFFECTS
Allergic reactions to amoxicillin are possible in animals, which quickly disappear after discontinuation of the drug. Intoxication due to an overdose is almost impossible. If allergic reactions occur, it is advisable to administer corticosteroids and adrenaline to animals.
CONTRAINDICATIONS
Hypersensitivity to amoxicillin and other penicillins. Do not administer intravenously. Not allowed for rabbits, hamsters, guinea pigs and gerbils. Amoxicillin should not be mixed with other drugs in the same syringe, and should not be used simultaneously with bacteriostatic chemotherapeutic agents. The drug should not be prescribed for infections caused by bacteria that form penicillinase.
SPECIAL INSTRUCTIONS
Animals may be slaughtered for meat 14 days after drug administration has been stopped. The meat of animals forcedly slaughtered before the expiration of the specified period can be used for feeding fur-bearing animals or for the production of meat and bone meal. Milk from animals injected with amoxicillin suspension is allowed to be used for food purposes after 48 hours after the end of treatment. Milk obtained from animals during the period of application of amoxicillin and before the expiration of 48 hours after the last administration of the drug is used for feeding animals.
STORAGE CONDITIONS
With precautions (list B). In a dry, dark place and out of the reach of children at a temperature of 5 to 25 ° C. Shelf life – 3 years.
Antibiotic use for severe toothache (irreversible pulpitis)
This translation is out of date. Please click here for the latest English version of this review.
Survey question
Are oral antibiotics effective and safe for treating the pain of irreversible pulpitis (inflammation of a nerve inside a tooth/nerve damage)?
Relevance
Irreversible pulpitis occurs where the dental pulp (the tissue inside the tooth that contains the nerve) has been damaged beyond repair. It is characterized by severe pain (toothache), enough to wake you up at night, and is considered one of the most common reasons patients seek emergency dental care. Any tooth can be affected, in individuals of any age, and usually irreversible pulpitis is a direct result of dental caries, a cracked tooth, or trauma, and therefore tends to occur more frequently in older patients.
The “standard of care” for irreversible pulpitis is to promptly remove the pulp from the affected tooth. This standard is now widely accepted, but in some parts of the world it is still customary to prescribe antibiotics.
Study characteristics
The evidence on which this review is based is current to 27 January 2016. One study of 40 people with irreversible pulpitis (nerve damage) was included. There were two groups of 20 people, one group was treated with penicillin 500 mg, the other with placebo (no active ingredient) every six hours for seven days. In addition, all participants received pain relievers (ibuprofen and paracetamol (acetaminophen) in combination with codeine).
Main results
Antibiotics do not significantly reduce toothache caused by irreversible pulpitis.