What is ceftriaxone and how does it work. What are the common uses for ceftriaxone. What side effects can ceftriaxone cause. How is ceftriaxone administered and dosed. What drug interactions should be avoided with ceftriaxone. Who should not take ceftriaxone. How should ceftriaxone be stored and handled.

What is Ceftriaxone and How Does it Work?

Ceftriaxone is a powerful antibiotic medication that belongs to the cephalosporin class of drugs. It works by interfering with bacteria’s ability to form cell walls, ultimately killing the bacteria and stopping infections. Ceftriaxone is administered via injection into a muscle or vein and is used to treat or prevent a variety of bacterial infections.

How exactly does ceftriaxone combat bacterial infections? Ceftriaxone binds to specific proteins called penicillin-binding proteins (PBPs) that are involved in bacterial cell wall synthesis. By inhibiting these PBPs, ceftriaxone prevents bacteria from properly forming their cell walls, leading to cell death. This mechanism allows ceftriaxone to be effective against many types of bacteria that cause common infections.

Common Uses and Indications for Ceftriaxone

Ceftriaxone is prescribed to treat a wide range of bacterial infections throughout the body. Some of the most common uses include:

• Respiratory tract infections like pneumonia and bronchitis
• Urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Meningitis (infection of the brain and spinal cord lining)
• Intra-abdominal infections
• Gonorrhea and other sexually transmitted infections
• Surgical infection prevention

Is ceftriaxone effective against all types of infections? While ceftriaxone has a broad spectrum of activity, it is most effective against gram-negative bacteria. It may be less effective against certain gram-positive bacteria and is not typically used for viral or fungal infections. Your doctor will determine if ceftriaxone is appropriate based on the suspected or confirmed cause of your infection.

Ceftriaxone Dosage and Administration

Ceftriaxone is only available as an injectable medication and must be administered by a healthcare professional. The dosage and frequency depend on several factors:

• Type and severity of infection
• Patient age and weight
• Kidney and liver function
• Other medications being taken

For most adult infections, typical dosages range from 1-2 grams given once daily or divided into two doses. Treatment duration is usually 4-14 days for most infections, though some may require longer courses. Single-dose treatment may be used for certain conditions like uncomplicated gonorrhea.

How is ceftriaxone administered? Ceftriaxone can be given as an intramuscular (IM) injection or as an intravenous (IV) infusion. The IV route is more common for hospitalized patients or those with severe infections. IM injections are often used in outpatient settings or for single-dose treatments. Your healthcare provider will determine the most appropriate administration method based on your specific situation.

Potential Side Effects of Ceftriaxone

Like all medications, ceftriaxone can cause side effects in some patients. Common side effects include:

• Injection site pain or inflammation
• Diarrhea
• Nausea or vomiting
• Headache
• Rash or itching

More serious but less common side effects may include:

• Severe allergic reactions (anaphylaxis)
• Clostridioides difficile infection (severe diarrhea)
• Blood disorders
• Kidney problems
• Gallbladder issues (especially with prolonged use)

Can ceftriaxone cause antibiotic resistance? While ceftriaxone is a powerful antibiotic, overuse or misuse can contribute to the development of antibiotic-resistant bacteria. To minimize this risk, it’s crucial to only use ceftriaxone when prescribed by a healthcare professional and to complete the full course of treatment as directed.

Drug Interactions and Precautions

Ceftriaxone can interact with other medications, potentially altering their effectiveness or increasing the risk of side effects. Some important interactions to be aware of include:

• Calcium-containing products: Can form precipitates when given concurrently with ceftriaxone, especially in infants
• Oral contraceptives: May reduce effectiveness, requiring additional birth control methods
• Warfarin and other blood thinners: May increase bleeding risk
• Probenecid: Can increase ceftriaxone levels in the body

Are there any dietary restrictions while taking ceftriaxone? Unlike some antibiotics, ceftriaxone does not have significant interactions with food. However, maintaining a balanced diet and staying well-hydrated can help support your body’s immune system and recovery process during treatment.

Special Precautions

Certain groups of patients may require special precautions or monitoring while taking ceftriaxone:

• Patients with a history of allergies to penicillins or other cephalosporins
• Individuals with kidney or liver disease
• Patients with a history of gastrointestinal disease, especially colitis
• Pregnant or breastfeeding women
• Newborns and premature infants

Contraindications: Who Should Not Take Ceftriaxone?

While ceftriaxone is generally safe for most patients, there are some situations where it should not be used:

• Known allergy to ceftriaxone or other cephalosporin antibiotics
• Severe, immediate allergic reaction to penicillin antibiotics
• Newborns with high bilirubin levels (hyperbilirubinemia)
• Premature infants receiving calcium-containing IV solutions

Why is ceftriaxone contraindicated in certain newborns? In newborns, especially those born prematurely or with high bilirubin levels, ceftriaxone can displace bilirubin from albumin binding sites. This can increase the risk of kernicterus, a serious neurological condition. Additionally, ceftriaxone can form precipitates with calcium-containing solutions, which is particularly dangerous in the small blood vessels of infants.

Storage and Handling of Ceftriaxone

Proper storage and handling of ceftriaxone are essential to maintain its effectiveness and safety:

• Store unmixed vials at room temperature (20-25°C or 68-77°F)
• Protect from light
• Keep out of reach of children
• Once reconstituted, use within specified time frame (varies by preparation method)
• Do not use if the solution is cloudy or contains particles

How should unused or expired ceftriaxone be disposed of? Do not dispose of ceftriaxone in household trash or flush it down the toilet. Instead, ask your pharmacist about proper disposal methods for medications. Many communities have drug take-back programs that safely dispose of unused medications.

Monitoring and Follow-up During Ceftriaxone Treatment

While taking ceftriaxone, your healthcare provider may recommend certain monitoring steps to ensure the medication is working effectively and to catch any potential side effects early:

• Regular blood tests to check kidney and liver function
• Monitoring of symptoms to assess infection improvement
• Probiotic supplementation to support gut health
• Follow-up appointments to determine if treatment duration is appropriate

What signs should prompt immediate medical attention during ceftriaxone treatment? Seek immediate medical care if you experience signs of a severe allergic reaction (such as difficulty breathing, swelling of the face or throat, or severe rash), persistent severe diarrhea, unusual bleeding or bruising, or yellowing of the skin or eyes.

Long-term Considerations

While ceftriaxone is typically used for short-term treatment of acute infections, there are some long-term considerations to keep in mind:

• Impact on gut microbiome: Like all antibiotics, ceftriaxone can disrupt the balance of beneficial bacteria in the gut. This may lead to temporary digestive issues or increase the risk of opportunistic infections.
• Antibiotic resistance: Repeated or prolonged use of ceftriaxone may contribute to the development of antibiotic-resistant bacteria.
• Future antibiotic efficacy: Your history of ceftriaxone use may influence future antibiotic choices if you develop another infection.

How can patients help prevent antibiotic resistance? To combat antibiotic resistance, it’s crucial to only use antibiotics like ceftriaxone when truly necessary, complete the full prescribed course, and never share antibiotics with others or use leftover antibiotics from previous treatments.

Alternatives to Ceftriaxone

While ceftriaxone is a versatile and effective antibiotic, there may be situations where alternative treatments are preferred. Some potential alternatives include:

• Other cephalosporin antibiotics (e.g., cefotaxime, cefepime)
• Fluoroquinolones (e.g., ciprofloxacin, levofloxacin)
• Carbapenems (e.g., meropenem, imipenem)
• Combination therapies with other antibiotic classes

The choice of alternative depends on factors such as the specific infection, bacterial susceptibility, patient allergies, and local antibiotic resistance patterns.

Are there any non-antibiotic alternatives for treating bacterial infections? While antibiotics are the primary treatment for most bacterial infections, some minor infections may be managed with supportive care, such as rest, hydration, and over-the-counter pain relievers. Additionally, preventive measures like vaccines and good hygiene practices can help reduce the need for antibiotic treatment in some cases.

Future Developments in Antibiotic Therapy

As antibiotic resistance continues to be a global health concern, researchers are exploring new approaches to combat bacterial infections:

• Development of new antibiotic classes
• Combination therapies to enhance efficacy and reduce resistance
• Targeted delivery systems to improve antibiotic penetration
• Bacteriophage therapy as an alternative to traditional antibiotics
• Immunomodulatory approaches to enhance the body’s natural defenses

These ongoing research efforts aim to provide more treatment options and preserve the effectiveness of existing antibiotics like ceftriaxone for future generations.

Rocephin – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

Ceftriaxone belongs to the family of antibiotics known as cephalosporins. It is used to prevent or treat certain infections caused by bacteria. It is given by injection only into a muscle or vein.

Ceftriaxone is often used to treat infections of the lung, urinary tract, skin, abdomen, bone, joint, and lining of the brain (meningitis), depending on the bacteria causing them. It can also be used to treat gonorrhea (a sexually transmitted infection).

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Rocephin is no longer being manufactured for sale in Canada. For brands that may still be available, search under ceftriaxone. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

How should I use this medication?

To treat bacterial infections, the recommended dose and dosing schedule of ceftriaxone varies according to the specific infection being treated, the response to therapy, and other medications or treatments being used. The dose administered is also based on age, body size, and kidney and liver function. For moderate to severe infections in adults, the dose ranges from 1 g to 2 g daily given once every 24 hours or divided into 2 equal doses and given every 12 hours.

For uncomplicated gonorrhea in adults, one dose of 250 mg is injected into a muscle.

For children 12 years of age and under, the dose is based on body weight and is given every 12 hours. The maximum daily dose for adults and children is 4 g. The duration of treatment depends on the type of infection and usually ranges from 4 to 14 days. Some infections require only one dose while others require treatment for several weeks.

Ceftriaxone is injected into a vein or into a muscle by a health care professional under the supervision of your doctor.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor.

Store this medication (as unmixed vials) at room temperature, protect it from light, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not use this medication if you:

• are allergic to ceftriaxone or any ingredients of this medication
• are allergic to other cephalosporins (e.g., cephalexin) or penicillins (e.g., penicillin, amoxicillin)
  • the risk of developing a reaction to ceftriaxone given a history of cephalosporin or penicillin allergy is relatively low, but check with your health care provider before starting treatment

Do not give this medication to a newborn or premature infant who has high amounts of bilirubin in their blood.

Do not give this medication to a newborn who is receiving (or expected to receive) calcium-containing intravenous solutions (calcium-containing solutions should not be given within 5 days of ceftriaxone in infants up to 10 weeks of age).

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• dizziness
• headache
• mild diarrhea

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• chills
• fever
• pain, redness, and swelling at site of injection
• rash

Stop taking the medication and seek immediate medical attention if any of the following occur:

• severe, persistent diarrhea
• symptoms of a severe allergic reaction, e.g.:
  • difficulty breathing
  • hives
  • swelling of the mouth, throat, or tongue

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergic reactions: Ceftriaxone can cause severe allergic reactions. If you develop symptoms of a severe allergic reaction (hives; difficulty breathing; swelling of the mouth, tongue, or throat), get immediate medical attention.

Anemia: Although rare, certain drugs can cause a blood condition called hemolytic anemia, where people have low red blood cells due to premature destruction of this type of blood cell. If you have a history of cephalosporin-related hemolytic anemia, you should talk to your doctor before starting treatment.

Blood tests: Depending on various factors, including how long you will be receiving treatment, your doctor may order blood tests while you are taking ceftriaxone.

Calcium-containing solutions: The interaction with calcium-containing solutions has only been reported for newborns. For all other people, ceftriaxone can be administered before or after calcium-containing solutions provided that the infusion lines are flushed well in between the solutions. In newborns, calcium-containing solutions should not be given within 5 days for infants up to 10 weeks of age.

Gallbladder disease: If you have gallbladder disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney problems: Ceftriaxone may cause kidney stones. If you have high calcium levels in your urine or a history of kidney stones, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Low vitamin K: People with impaired vitamin K synthesis or low vitamin K stores (e.g., chronic liver disease and malnutrition) may require monitoring of blood clotting during treatment, as ceftriaxone may decrease clotting ability.

Overgrowth of organisms: Treatment with this antibiotic may allow normal fungus or types of bacteria not killed by the antibiotic to overgrow, causing unwanted infections.

Stomach and bowel disorders: If you have stomach and bowel problems (especially colitis), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: Ceftriaxone passes into breast milk in small amounts. If you are a breast-feeding mother and are taking ceftriaxone, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Newborn and premature infants (up to the age of 10 weeks) should not receive calcium-containing solutions within 5 days of receiving ceftriaxone.

What other drugs could interact with this medication?

There may be an interaction between ceftriaxone and any of the following:

• anticoagulant medications (e. g., warfarin)
• solutions injected into a vein that contain calcium
• typhoid vaccine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Rocephin

Ceftriaxone: Uses, Interactions, Mechanism of Action

Injection, powder, for solution	Intramuscular; Parenteral	1 G/3.5ML
Injection, powder, for solution	Intramuscular; Parenteral	500 MG/2ML
Injection, powder, for solution	Intravenous; Parenteral	1 G/10ML
Powder, for solution		2 G
Injection, powder, for solution	Parenteral	0.5 g
Injection, powder, for solution	Intravenous; Parenteral	1000 MG/10ML
Injection, powder, for solution		1000 mg
Injection, powder, for solution	Intramuscular	1 G/3. 5ML
Injection, powder, for solution	Intramuscular; Intravenous	500 mg/5ml
Injection, powder, for solution	Intramuscular
Injection, powder, for solution	Intramuscular	1 gr
Injection, powder, for solution	Intravenous	1 gr
Injection, powder, for solution	Intramuscular	250 mg
Injection, powder, for solution	Intravenous	250 mg
Injection, powder, for solution	Intravenous	500 mg
Injection, solution	Intramuscular; Intravenous
Injection, powder, for solution	Intramuscular	0.5 g
Injection, solution	Intramuscular; Intravenous	1 g
Injection, powder, for solution	Intravenous	0.5 g
Injection, powder, for solution	Parenteral	1 g
Injection, powder, for solution		250 MG
Injection, powder, for solution	Intramuscular; Intravenous	250 mg
Injection, powder, for solution	Intramuscular; Intravenous	500 mg
Injection, powder, for solution	Parenteral	2 g
Injection, powder, for solution	Intravenous	2 gr
Injection, powder, for solution	Parenteral
Injection, powder, for solution	Parenteral	250 mg
Injection, powder, for solution	Intravenous	1. 184 g
Injection, powder, for solution	Intramuscular; Intravenous
Injection, powder, for suspension	Parenteral	1 g
Injection, powder, lyophilized, for solution	Intramuscular; Intravenous	1 g
Injection, powder, for solution	Intravenous	1 g
Injection, powder, for solution	Intramuscular	1 g/1
Injection, powder, for solution	Intramuscular	250 mg/1
Injection, powder, for solution	Intramuscular; Intravenous	1 g/10mL
Injection, powder, for solution	Intramuscular; Intravenous	2 g/1
Injection, powder, for solution	Intramuscular; Intravenous	250 mg/1
Injection, powder, for solution	Intravenous	1 g/1
Injection, powder, for solution	Intravenous	10 g/1
Injection, powder, for solution	Intravenous	10 g/100mL
Injection, powder, for solution	Intravenous	100 mg/1mL
Injection, powder, for solution	Intravenous	100 g/1
Injection, powder, for solution	Intravenous	2 g/1
Injection, powder, lyophilized, for solution	Intravenous	100 mg/1mL
Powder, for solution	Intramuscular; Intravenous	1 g/1
Powder, for solution	Intramuscular; Intravenous	2 g/1
Powder, for solution	Intramuscular; Intravenous	250 mg/1
Powder, for solution	Intramuscular; Intravenous	500 mg/1
Injection, powder, for solution	Intramuscular; Parenteral	250 MG/2ML
Injection, powder, for solution	Intramuscular; Intravenous	1. 0 g
Injection, powder, for solution	Intramuscular; Intravenous	2.0 g
Injection, powder, for solution	Intravenous; Parenteral	500 MG/5ML
Injection, powder, for solution	Parenteral	1 G/10ML
Powder, for solution	Parenteral	2 G
Injection, powder, for solution	Intramuscular
Injection, powder, for solution	Intramuscular; Parenteral	250 MG
Injection, powder, for solution	Intramuscular; Parenteral	500 MG
Powder, for solution	Intravenous	100 g / bag
Injection, powder, for solution	Intramuscular	250 MG/2ML
Injection, powder, for solution	Intramuscular	500 MG/2ML
Injection, powder, for solution	Intravenous	1 G/10ML
Solution	Intravenous	1000 mg / 50 mL
Solution	Intravenous	2000 mg / 50 mL
Injection, powder, for solution	Intravenous	2000 mg/bottle
Injection, powder, for solution	Intramuscular; Intravenous	500 mg/vial
Injection, powder, for solution	Intramuscular; Intravenous	1000 mg/vial
Injection, powder, for solution	Intramuscular; Intravenous	1 g/1
Injection, powder, for solution	Intramuscular; Intravenous	500 mg/1
Injection, powder, for solution	Intravenous	500 mg/1
Powder, for solution	Intramuscular; Intravenous	0. 25 g / vial
Powder, for solution	Intramuscular; Intravenous	10 g / vial
Powder, for solution	Intramuscular; Intravenous	1 g / vial
Powder, for solution	Intramuscular; Intravenous	2 g / vial
Powder, for solution	Intramuscular; Intravenous	250 mg / vial
Powder, for solution	Intramuscular; Intravenous	500 mg / vial
Powder, for solution	Intravenous	10 g / vial
Injection, powder, for solution	Intravenous	2 g
Injection
Injection, powder, for solution	Intramuscular; Intravenous	1 g
Injection, powder, for solution
Injection, powder, for solution	Intravenous
Powder, for solution
Injection, solution	Intramuscular	0. 5 g
Injection	Intravenous	0.5 g
Injection, solution	Intramuscular	1 g
Solution	Intravenous
Injection, powder, for solution	Intramuscular	1 g
Injection, powder, for solution	Intramuscular	500 mg
Kit	Intramuscular; Intravenous; Topical
Injection, solution	Intravenous	0.5 g
Injection, solution	Intravenous	1 g
Injection	Intramuscular; Intravenous
Injection, powder, for solution	Intramuscular	0.5 gr
Injection, powder, for solution	Intravenous	0.5 gr
Injection; injection, powder, for solution		1 g
Injection, powder, for solution		1 g
Injection, powder, for solution	Intramuscular; Intravenous	1000. 0 mg
Injection, powder, for solution	Intramuscular; Intravenous	2000.0 mg
Injection, powder, for solution	Intramuscular; Intravenous	1000 mg
Injection, powder, for solution	Intramuscular; Intravenous	2000 mg
Injection	Intramuscular	1000 mg
Injection	Intravenous	1000 mg
Injection	Intramuscular	250 mg
Injection	Intramuscular	500 mg
Injection	Intramuscular	0.5 g/2ml
Injection	Intravenous	0.5 g/5ml
Injection	Intravenous	1 g/10ml
Injection	Intramuscular	1 g/3.5ml
Injection	Intravenous	2 g
Powder		2 G
Injection		1 g
Injection, powder, for solution	Intramuscular; Parenteral	1 MG/3. 5ML
Injection, powder, for solution	Intravenous
Injection, powder, for solution	Intramuscular; Parenteral	1 G
Injection, powder, for solution	Intravenous; Parenteral	250 MG/5ML
Injection, powder, for solution	Parenteral	500 mg
Injection, solution	Intravenous	1 g/50mL
Injection, solution	Intravenous	2 g/50mL
Injection, powder, for solution	Intramuscular	1 g/vial
Injection, powder, for solution	Intravenous	1 g/vial
Powder, for solution	Intravenous	1 g / vial
Injection, solution	Intramuscular
Injection	Intravenous	1 g
Injection	Intravenous	250 mg
Injection	Intravenous
Injection	Intramuscular
Injection, powder, for solution	Intramuscular; Intravenous
Injection, solution	Intravenous	2 g
Injection, powder, for solution	Intravenous; Parenteral	1 G
Powder
Injection, solution	Intramuscular
Injection, solution	Intravenous
Injection, powder, for solution	Intramuscular; Intravenous	0. 25 g
Injection, powder, for solution	Intramuscular; Intravenous	0.5 g
Injection, powder, for solution	Intramuscular; Intravenous	2 g
Injection	Intramuscular; Intravenous	1 g
Injection	Intramuscular; Intravenous	250 MG
Injection	Intramuscular; Intravenous	1 gr
Injection	Intramuscular; Intravenous	0.5 gr
Injection		1000 MG
Injection		500 MG
Injection, powder, for solution		2 G
Injection, powder, for solution		500 MG
Injection, powder, for solution		250 mg/1vial
Injection, powder, for solution		500 mg/1vial
Powder		500 mg/1vial
Powder		250 mg/1vial
Powder

Cheap analogs of expensive antibiotics: analogs of expensive drugs

Antibiotics are one of the most expensive groups of drugs. And if the cost of “old” antibiotics is more or less acceptable, then new broad-spectrum antibiotics are incredibly expensive, which is not surprising, because the development of one new antibiotic costs approximately 1 billion US dollars.

If you think about this topic, you can understand that there are not so many new antibiotics, because not only do development and clinical studies take decades, but also the cost of the project is equal to the cost of space flight. In this regard, very few pharmaceutical companies in the US and Europe can conduct such expensive research.

For example, Linezolid (trade name Zyvox) is the latest antibiotic to enter the market and is patented by Pfizer. At the same time, it was synthesized back in 1990, and only in 2000 was it first put into practice.

And what about other pharmaceutical companies, including domestic ones, who cannot afford such expenses? The answer is simple – they produce generics, that is, analogues of long-known antibiotics, with the same active ingredient as the original drug, but under a different trade name. The cost of such drugs is often lower than the cost of the original drug, but there are also opposite cases.

When prescribing antibiotic therapy, doctors can prescribe both the original drug – an expensive antibiotic (occurs less often), and its analogue – a cheap antibiotic (in most cases). The reason for this is the work of medical representatives of pharmaceutical companies and distributors. So if the doctor prescribed you an expensive antibiotic, do not rush to buy it at the expense of the budget. Most likely, he has a cheaper analogue, which a pharmacist in a pharmacy can also advise you if you ask him about it. However, it is worth remembering that from January 1, 2023 in Ukraine, you can buy an antibiotic only with an electronic prescription, which is pre-written to you by a doctor. The Doc.ua service also provides an opportunity to get an electronic prescription for antibiotics in just a few clicks. You can also buy all the necessary prescription drugs at the Doc.ua Pharmacy.

In this article we have provided a list of analogues of the most famous and widely used antibiotics.

Antibiotics for colds list Ukraine

Antibiotics of the penicillin group

Flemoxin Solutab cases of bronchitis, sinusitis, pneumonia, peptic ulcer, cystitis and other

The average cost of Flemoxin Solutab and Ospamox is 80-150 UAH. Its analogue is Amoxil (amoxicillin analogues, amoxiclav analogues). The average cost is 50-70 UAH (inexpensive antibiotics for colds).

Antibiotics of the group of inhibitor-protected aminopenicillins

Flemoclav Solutab , Augmentin (amoxicillin and clavulanic acid).

This antibiotic is used to treat mild and uncomplicated cases of bronchitis, sinusitis, pneumonia, peptic ulcer, cystitis, etc. caused by b-lactamase producing bacteria.

The average cost of Flemoclav Solutab is 100-150 UAH, Augmentin is 130-190 UAH.

Flemoclav Solutab analogues, Augmentin analogues ( cheap broad-spectrum antibiotics):

Bactoclav is the cheapest antibiotic, the average price is 60 – 70 UAH.

Amoxil K, Medoklav, Abiklav, Amoksiklav 2x, Betaklav, are also inexpensive antibiotics for colds.

Antibiotics of the cephalosporin group

Emsef , Diacef , Denicef ​​ (ceftriaxone analogues in tablets) – Lorakson, Medakson (ceftriaxone analogue in tablets), Ceftriaxone-Darnitsa, Ceftriaxone-KMP, Ceftriaxone-Lekhim.

Antibiotics treat diseases such as sepsis, meningitis, disseminated Lyme borreliosis (early and late stages of the disease), infections of the abdominal cavity, etc. 27 (cefuroxime) – Aksetin, Aksef , Auroxetil.

Antibiotics treat urinary tract infections – cystitis, pyelonephritis, urethritis; skin and soft tissues – furunculosis, pyoderma, impetigo, etc.

Quadrocef , Roxipim , Abipim , Denipim 900 26, Exipim , Septipim (cefepime) – Cefepim-Lekhim, Cefepim Abryl, Cefepim Aurobindo.

Antibiotics treat respiratory diseases (pneumonia and bronchitis), urinary tract infections, and skin and soft tissue infections.

Eurosidim , Ceftazidime-Vista (ceftazidime) – Ceftazidime Yuria-pharm, Ceftum, Zacef, Ceftazidime-BHFZ.

These antibiotics are used to treat meningitis, sepsis and other illnesses.

Sorcef , Cefinac , Suprax Solutab (cefixime) – Lopraks, Opticef, Cefix.

Antibiotics treat diseases such as pharyngitis, tonsillitis, sinusitis, acute and chronic bronchitis, otitis media, and urinary tract infections.

Macrolide antibiotics

Sumamed , Azax , Azitrox , Aztec , Hemomycin , 9002 6 Zybax (azithromycin analogues are expensive, sumamed analogues) – Azibiot, Azipol, Zitrox, Ormax, Azimed (the best analogue sumamed) Azicin, Zoxy, Azithromycin-Astrapharm, Azithromycin-Health, Azithromycin-BHFZ, Azithromycin-Red Star, Ziomycin (azithromycin analogues of the drug).

These name antibiotics are used to treat pharyngitis, tonsillitis, sinusitis, otitis media, as well as acute bronchitis, pneumonia. 9Ora dro (clarithromycin analogs) – Aziklar, Clarithromycin-Health, Clarithromycin-Astrafarm, Clarithromycin-Darnitsa, Clarithromycin-Arterium, Clubax.

Antibiotics treat diseases such as infections of the upper respiratory tract and ENT organs: tonsillopharyngitis, otitis media, acute sinusitis, as well as infections of the lower respiratory tract: acute bronchitis, exacerbation of chronic bronchitis and others.

Antibiotics of the tetracycline group

Unidox Solutab (doxycycline) – its inexpensive antibiotics – analogues: Doxycycline-Teva, Doxycycline-Darnitsa, Doxycycline-BHFZ (inexpensive antibiotic).

Antibiotics are used to treat pharyngitis, bronchitis, tracheitis, bronchopneumonia, as well as otitis media, tonsillitis, sinusitis and others.

Antibacterial drugs of the fluoroquinolone group

Ofloxin (ofloxacin) – Ofloxacin-Darnitsa, Ofloxacin-Lekhim (inexpensive antibiotic).

Antibiotics treat infectious and inflammatory diseases of bones and joints, abdominal cavity, diseases of the kidneys (pyelonephritis) and urinary tract (cystitis, urethritis.

Abiflox , Levaksela, Lebel , Levoksimed, Levomak , Tigeron (levofloxacin) – Levokilz, Levofloxacin-Lekhim, Levofloxacin-Health, Floxium, Leflok.

Antibiotics are used to treat acute sinusitis, exacerbations of chronic bronchitis, community-acquired pneumonia, complicated urinary tract infections.

Avelox , Moxicum, Timoksi, Moxifloxacin-Sandoz (moxifloxacin) – Moxifloxacin-Lekhim, Moflaxa, Moxifloxacin-Pharmex, Atovax.

Antibiotics are used to treat acute sinusitis, exacerbation of chronic bronchitis, community-acquired pneumonia.

Cifran , Tsiprinol , Tsiprolet analogues , Flaprox, 900 26 Ciprobel (ciprofloxacin analogues are expensive) – Ciprofloxacin-Euro, Ciprofloxacin-Lekhim, Ciprofloxacin-Astrapharm, Citeral.

An antibiotic is used to treat sepsis and peritonitis and to prevent and treat infections in immunosuppressed patients.

Nitroimidazole antibacterials

Strong antibiotics in tablets

Trichopolum , Efloran (metronidazole) – Metrogyl, Metressa, Metronidazole-Health, Metronidazole-Darnitsa, Metronidazole-Infusion, Metronid Zol-Yuria Pharm, Metronidazole Lubnypharm.

Antibiotics treat protozoal infections: extraintestinal amoebiasis, including amoebic liver abscess, intestinal amoebiasis (amebic dysentery), trichomoniasis, giardiasis, balantidiasis, cutaneous leishmaniasis, trichomonas vaginitis, trichomonas urethritis, and others.

Ornigil , Ornizol, Ornimac (ornidazole) – Ornidazol-Darnitsa, Ornidazol-Novofarm, Ornidazol-Infusion.

Antibiotics are used to treat trichomoniasis, amoebiasis, giardiasis, and a mild antibiotic is used to prevent postoperative complications.

Antibiotic analogues table

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The most effective antibiotics for pneumonia, treatment regimen for children and adults

Publication date: 02/04/2021

CONTRAINDICATIONS ARE AVAILABLE. SPECIALIST CONSULTATION IS NECESSARYAntibiotics in capsulesAntibiotics in tabletsWet coughFor immunityAntibiotic ointmentsAnti-inflammatory dropsAntibiotic solutions for external useDry coughPillsPillsPillsPills against inflammationPills against temperatureImmunity strengthening

The author of the article

Grishina Alexandra Nikolaevna,

Therapist

All authors

Contents of the article

• What is pneumonia
• Antibiotics for pneumonia in adults, general principles
• Types of antibiotics for the treatment of pneumonia
• Regimen for the treatment of pneumonia in adults with antibiotics
• The most effective antibiotics in the treatment of viral pneumonia
• Why antibiotics are ineffective

A hundred years ago, pneumonia was rightfully considered an extremely dangerous disease, as it often led to the death of the patient. The disease still poses a threat today. But thanks to the advent of antibacterial drugs, its danger has significantly decreased. When used properly as prescribed by a doctor, antibiotics provide recovery and prevent the complications of pneumonia. Conversely, the uncontrolled use of these drugs can cause irreparable harm to the health of the patient.

What is pneumonia

This is a lung disease, mainly of an infectious nature, affecting the alveoli (terminal sections of the lungs) and disrupting gas exchange at their level.

The disease is manifested by:

• Chest pain
• Cough with phlegm
• Fatigue
• Shortness of breath, shortness of breath
• High fever

Symptoms range from mild to severe. It depends on the type of microorganism that caused the disease, the age of the patient and the general state of health. In adults who do not have serious pathologies, the disease is milder. It poses the greatest danger to young children, the elderly, people with weakened immune systems.

If pneumonia is suspected, laboratory tests of blood and sputum, chest X-ray are performed. For a more detailed examination, CT (computed tomography) of the lungs is used. If the diagnosis is confirmed, the doctor prescribes antibiotics. Their use is necessary to prevent further development of infection and prevent complications.

Antibiotics for pneumonia in adults, general principles

Treatment begins immediately after radiological confirmation of the diagnosis. For therapy, doctors use broad-spectrum antibiotics. After an accurate determination of the microbial pathogen in the sputum, the treatment plan can be adjusted: a drug is prescribed to which the identified microorganism is most sensitive.

Also, the replacement of one antibacterial agent with another is carried out if:

• After taking the drug, improvement does not occur within 3 days.
• Significant side effects have occurred from the use of a particular agent.
• The antibiotic is too toxic for a certain group of patients (children, pregnant women).

A decrease in temperature, a decrease in shortness of breath, signs of intoxication, and the amount of sputum 72 hours after the start of treatment indicates the correct prescription of the drug.

Types of antibiotics for the treatment of pneumonia

When prescribing drugs of this group, the following is taken into account:

• Type of pneumonia (lobar, aspiration, focal, hilar)
• Patient’s age
• Severity of the condition

Antibiotics of the new generation are considered to be the most effective. Their advantage lies in the rapid impact on pathogenic microorganisms, fewer side effects, and better tolerance by patients. Modern drugs have a long duration of action, so they are taken only 1-2 times a day. While antibacterial agents of the 1st and 2nd generations – up to four.

Each group of antibacterial agents is effective against a specific type of pathogen. So, to combat pneumococci, the penicillin series is used. With pneumonia caused by chlamydia and mycoplasmas, macrolides, fluoroquinols are prescribed. And E. coli destroy cephalosporins.

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Treatment regimen for pneumonia in adults with antibiotics

Mild to moderate illness can be treated at home. Therapy is carried out with antibiotics in tablets, capsules, in the form of a suspension or syrup. In severe and complicated forms, injections are prescribed. If the disease is very difficult, in the first days the drugs are administered intravenously, and later – intramuscularly. And only after the condition improves, the patient is transferred to a tablet intake. This transition from one form of drug administration to another is called a “stepped” course of treatment.

Prescribe antibacterial agents for at least 7 days. Depending on the result of the control X-ray examination, then they are either canceled or a treatment course is prescribed with new antibiotics.

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The most effective antibiotics in the treatment of viral pneumonia

For the treatment of viral pneumonia, completely different drugs are used than with therapy for other forms of this disease. This is due to the fact that its pathogens are viruses that are not sensitive to antibacterial drugs. Therefore, their use is not only useless, but also dangerous. The use of antibiotics for other purposes causes the development of resistance in pathogenic bacteria. And when the drugs are really needed, they may not have the desired effect. Antibiotics are used only with a mixed nature of pneumonia or the development of purulent complications.