Bactrim DS Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This medication is a combination of two antibiotics: sulfamethoxazole and trimethoprim. It is used to treat a wide variety of bacterial infections (such as middle ear, urine, respiratory, and intestinal infections). It is also used to prevent and treat a certain type of pneumonia (pneumocystis-type).This medication should not be used by children less than 2 months of age due to the risk of serious side effects.This medication treats only certain types of infections. It will not work for viral infections (such as flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

How to use Bactrim DS

Take this medication by mouth, as directed by your doctor, with a full glass of water (8 ounces / 240 milliliters). If stomach upset occurs, take with food or milk. Drink plenty of fluids while taking this medication to lower the unlikely risk of kidney stones forming, unless your doctor advises you otherwise. Dosage is based on your medical condition and response to treatment.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping it too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Nausea, vomiting, diarrhea, and loss of appetite may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: muscle weakness, mental/mood changes, signs of kidney problems (such as change in the amount of urine, blood in the urine), extreme drowsiness, signs of low blood sugar (such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet).

Get medical help right away if you have any very serious side effects, including: headache that doesn’t go away, neck stiffness, seizures, slow/irregular heartbeat.

This medication may rarely cause serious (possibly fatal) allergic reactions and other side effects such as a severe peeling skin rash (such as Stevens-Johnson syndrome), blood disorders (such as agranulocytosis, aplastic anemia), liver damage, or lung injury. If you notice any of the following, get medical help right away: sore throat or fever that doesn’t go away, cough that doesn’t go away, nausea/vomiting that doesn’t stop, skin rash/blisters, itching/swelling (especially of the face/tongue/throat), new or worsening lymph node swelling, paleness, joint pain/aches, trouble breathing, easy bleeding/bruising, yellowing eyes or skin, unusual fatigue, dark urine.

This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn’t stop, abdominal or stomach pain/cramping, blood/mucus in your stool.

If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to sulfamethoxazole or trimethoprim; or to sulfa medications; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, certain blood disorders (such as porphyria, anemia due to folate vitamin deficiency), history of blood disorders caused by trimethoprim or sulfa medications, vitamin deficiency (folate or folic acid), severe allergies, asthma, decreased bone marrow function (bone marrow suppression), a certain metabolic disorder (G6PD deficiency), underactive thyroid, mineral imbalances (such as high level of potassium or low level of sodium in the blood).

This medication may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Tell your health care professional that you are using this medication before having any immunizations/vaccinations.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Get medical help right away if you get sunburned or have skin blisters/redness.

If you have diabetes, this product may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of low blood sugar (see Side Effects section). Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Older adults may be more sensitive to the side effects of this drug, especially skin reactions, blood disorders, easy bleeding/bruising, and a high potassium blood level.

Patients with AIDS may be more sensitive to the side effects of this drug, especially skin reactions, fever, and blood disorders.

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using sulfamethoxazole/trimethoprim. This medication may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

This drug passes into breast milk. While there have been no reports of harm to healthy infants, this drug may have undesirable effects on infants who are ill or premature or have certain disorders (jaundice, high blood levels of bilirubin, G6PD deficiency). Breast-feeding is not recommended for infants with these conditions. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: “blood thinners” (such as warfarin), dofetilide, methenamine, methotrexate.

This product may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this product.

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting/diarrhea, severe dizziness or drowsiness, mental/mood changes.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

If taking this medication for a long time, lab and/or medical tests (such as complete blood count, kidney function, potassium blood level, cultures) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Bactrim DS 800 mg-160 mg tablet

Color: whiteShape: ovalImprint: BACTRIM DS

This medicine is a white, oval, scored, tablet imprinted with “BACTRIM DS”.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Common and Rare Side Effects for Bactrim DS

COMMON side effects

If experienced, these tend to have a Severe expression i

If experienced, these tend to have a Less Severe expression i

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

If experienced, these tend to have a Less Severe expression i

RARE side effects

If experienced, these tend to have a Severe expression i

If experienced, these tend to have a Less Severe expression i

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Bactrim – instructions for use, doses, side effects, reviews of the drug Bactrim: – Encyclopedia of drugs RLS

Inside, after meals with sufficient liquid.

Bactrim ^®

Standard dosage for adults and children over 12 years of age is shown in Table 1.

Table 1-

Duration of treatment

For acute infections, Bactrim ^® should be given for at least 5 days or until the patient has been asymptomatic for 2 days. If after 7 days of therapy there is no clinical improvement, the patient’s condition should be re-evaluated for possible correction of treatment.

Dosing in special cases

Chanc. 4 measuring spoons of suspension 2 times a day. If after 7 days the healing of the skin element does not occur, you can extend the therapy for another 7 days. However, it should be borne in mind that the lack of effect may indicate the resistance of the pathogen.

Acute uncomplicated urinary tract infections. For women with acute uncomplicated urinary tract infections, a single dose of 8-12 scoops of the suspension is recommended. If possible, they should be taken in the evening after meals or before going to bed.

Patients on hemodialysis. After the usual loading dose, subsequent doses should be half or a third of the standard dose every 24-48 hours.

Pneumonia caused by Pneumocystis carinii. Up to 20 mg/kg/day of trimethoprim and up to 100 mg/kg/day of sulfamethoxazole in equal doses every 6 hours for 14 days.

The upper dose limit is determined according to the data indicated in Table 2.

Table 2

For the prevention of pneumonia caused by Pneumocystis carinii , adults and adolescents (over 12 years of age) are recommended to prescribe 4 measuring spoons of the suspension per day. For children, the recommended dose of trimethoprim is 150 mg/m ² / day and sulfamethoxazole 750 mg / m ² / day, divided into 2 equal doses, for 3 consecutive days every week. The total daily dose should not exceed 320 mg of trimethoprim and 1600 mg of sulfamethoxazole. In this case, you can use the following instructions presented in Table 3.

Table 3

Children

Children from 6 weeks to 5 months – 0.5 scoops of oral suspension 2 times a day (morning and evening), from 6 months to 5 years – 1 scoop 2 times a day, from 6 to 12 years old – 2 measuring spoons 2 times a day. This dosing regimen roughly corresponds to a daily dose of 6 mg/kg trimethoprim and 30 mg/kg sulfamethoxazole.

For severe infections, doses for children can be increased by 50%.

Nocardiosis

Adults – 12-16 scoops of suspension for at least 3 months. The dose should be adjusted depending on the age, body weight of the patient, kidney function and the severity of the disease. Sometimes treatment is continued up to 18 months.

Patients with impaired renal function. At Cl creatinine> 30 ml/min, the usual dose is prescribed, 15-30 ml/min – half the usual dose; <15 ml/min - apply Bactrim ^® is not recommended.

Patients of senile age. In normal renal function, the usual adult dose is prescribed.

Bactrim ^® forte

Standard dosage for adults and children over 12 years of age is shown in Table 4.

Table 4

Duration of treatment

In acute infections, Bactrim ^® forte should be given for at least 5 days or until the patient has been symptom-free for 2 days. If after 7 days of therapy there is no clinical improvement, the patient’s condition should be re-evaluated for possible correction of treatment.

Dosing in special cases

Chanc. 1 tab. 2 times a day. If after 7 days the healing of the skin element does not occur, you can extend the therapy for another 7 days. However, it should be borne in mind that the lack of effect may indicate the resistance of the pathogen.

Acute uncomplicated urinary tract infections. Women with acute uncomplicated urinary tract infections are recommended a single dose of 2-3 tablets. If possible, they should be taken in the evening after meals or before going to bed.

Hemodialysis patients. After the usual loading dose, subsequent doses should be half or a third of the standard dose every 24-48 hours.

Pneumocystis carinii pneumonia. Up to 20 mg/kg/day of trimethoprim and up to 100 mg/kg/day of sulfamethoxazole in equal doses every 6 hours for 14 days.

The upper dose limit is determined according to the data indicated in Table 5.

Table 5

For the prevention of pneumonia caused by Pneumocystis carinii , adults and adolescents (over 12 years old) are recommended to prescribe 1 tab./day. In children, for the prevention of pneumonia caused by Pneumocystis carinii, another dosage form of the drug Bactrim 9 should be used.0009 ® – oral suspension.

Nocardiosis

Adults – 3-4 tablets. for at least 3 months. The dose should be adjusted depending on the age, body weight of the patient, kidney function and the severity of the disease. Sometimes treatment is continued up to 18 months.

Patients with impaired renal function. At Cl creatinine >30 ml/min, the usual dose is prescribed, 15-30 ml/min – half the usual dose, <15 ml/min - Bactrim ^® forte is not recommended.

Patients of senile age. In normal renal function, the usual adult dose is prescribed.

instructions for use, description, reviews of patients and doctors, analogues

Some facts about the product:

Instructions for use

Presentation, composition and packaging

Bactrim is made as a liquid mixture for internal administration. The active ingredients are sulfamethoxazole and trimethoprim. Excipients:

• methylparaben;
• p-hydroxybenzoic acid propyl ester;
• flavoring agent;
• fragrances;
• distilled water.

According to the description, the solution is a homogeneous suspension of yellow-white or orange color with a fruity odor.
Packing – 50- and 100-mm glass containers in a set with a measuring spoon. The price of Bactrim is regulated by the legislation of the Russian Federation.

Pharmacological action

Bactrim is an antimicrobial agent with a complex spectrum of action. Sulfamethoxazole has a bacteriostatic effect when, as a result of blocking the reactions of PABA removal, the process of formation of dihydrofolic acid in bacterial cells is suppressed. Trimethoprim inhibits the fermentation and breakdown of folic acid, transforming dihydrofolate into tetrahydrofolate. Under the influence of the agent, two successive phases of the formation of imidazo-pyrimidines and biopolymers formed by nucleotide residues, which are responsible for the creation and development of pathogens, are inhibited. A feature of the drug is the formation of a high saturation of the material in various tissues and body fluids – bone fibers, prostate, kidneys, lungs, bile and cerebrospinal secretions, saliva, lacrimal fluid, in breast lactose.
After the introduction of 90% of the initial volume of the substance is absorbed into the tissues, reaching a maximum density after 1-4 hours. It is found in breast lactose. The level of connection with plasma proteins in sulfamethoxazole is 65%, in trimethoprim – 45%.
Cleavage reactions occur with the creation of acetylated metabolites that are not antimicrobially active. They are extracted by 80% through the urinary system within three days. A small part of the drug comes out through the digestive tract. The half-life in adult patients is within 9-12 hours, in newborns – 7-8 hours, from a year to 10 years – 5-6 hours. In patients with kidney pathologies and the older age group, the elimination time increases.

Readings

Bactrim is prescribed for infectious diseases of the urinary system, respiratory system, gastrointestinal tract, ENT organs, skin, bone tissue.

Contraindications

It is forbidden to use the medication for liver parenchyma disease, acute kidney pathologies, in case of severe forms of blood damage, high bilirubin levels. Caution is required for concomitant diseases of the thyroid organ, bronchial asthma. You can buy Bactrim at a pharmacy or in an online store.

Dosage and Administration

Bactrim is prescribed at a dose of 0.4 to 2 g 2 times a day. The portion for small children under 2 years old is set individually. The maximum daily dose cannot exceed 3.6 g. It is allowed to switch to Bactrim analogues only on the recommendation of a doctor.

Side effects

Most often, accidental phenomena against the background of the use of a combined antimicrobial chemical agent occur on the skin and in the digestive tract. There are complications from:

• blood formation and lymphatic system – decrease in the level of leukocytes, granulocytes, platelets, erythrocytes;
• immunity – nettle fever, angioedema, polyarteritis nodosa, infectious-allergic myocarditis, dermatitis, lupus erythematosus;
• metabolism – an increase in the amount of potassium in the blood serum, a decrease in the level of sodium, sugar;
• mentality – hallucinogenic and depressive states, lack of sleep, high fatigue, psychosis, clouding of consciousness, impaired attention, perception, thinking and emotions.

The appearance of complications after the use of Bactrim is possible from:

• central nervous organization – sensory disturbance, neuritis, meningitis-like conditions, convulsions, dizziness, cephalalgia, ringing in the ears;
• respiratory system – pneumonia;
• digestive department – nausea with or without vomiting, diarrhea, inflammation of the intestines, pancreas;
• hepatobiliary structure – activation of enzymes, increased levels of bilirubin, hepatitis, necrosis of hepatocytes, symptoms of the disappearance of the bile ducts;
• renal and urinary systems – kidney dysfunction, chronic tubulointerstitial nephritis, increased levels of urea, creatinine in the blood, the formation of salts in the urine, increased diuresis;
• skin – the appearance of a rash.

In HIV-infected patients during treatment with the introduction of high doses of Bactrim, according to doctors, pneumonia develops. In 20-25% of patients, the drug has to be discontinued due to severe side effects from:

• psychics – acute psychoses;
• nervous organization – hallucinations, aseptic meningitis, convulsive convulsions, trembling of the limbs like Parkinson’s syndrome, impaired motor skills, vestibular apparatus;
• digestive tract – lack of appetite, irritation of the pituitary surface of the oral cavity, neck, chin.

Many drugs containing sulfonamides cause collateral changes in the form of target-like rashes on the pituitary surface, photophobia. As a result of the use of Bactrim in the area of ​​the musculoskeletal structure, pain occurs in muscles, joints, up to destruction and necrosis of muscle tissue.

Overdose

With a strong overdose, nausea with vomiting, diarrhea, cephalgia, dizziness, impaired visual perception and cognitive abilities develop. Severe types of poisoning are characterized by the formation of salts in the urine, the appearance of blood and the impossibility of urination. Long-term use of chemical means suppresses the processes of blood formation, which causes a decrease in the level of platelets, leukocytes against the background of folic acid deficiency.
To prevent the absorption of the substance into the blood, forced diuresis is prescribed by alkalinizing the urine. Extrarenal blood purification is ineffective. The level of electrolytes and the state of the blood are monitored. In the event of the development of severe clinical changes in the blood or the onset of symptoms of jaundice, special therapy is prescribed. To reduce the effects of trimethoprim, calcium folinate is given in an amount of 3 to 6 mg per day. The duration of the course is one week. You can order Bactrim on a specialized pharmacy website.

Drug interactions

With the complex use of an antimicrobial syrup with anticoagulants of indirect influence, the effect of anticoagulants is significantly enhanced. Parallel administration with sulfonylurea metabolites causes an even sharper decrease in the sugar-lowering effect.
The combination of Bactrim with methotrexate enhances the toxic effect of the latter and leads to the development of pancytopenia due to a break in its connection with blood plasma proteins.
Under the influence of anti-inflammatory drugs in combination with Bactrim, the effect of both substances is summed up with the occurrence of side effects. With parallel administration with diuretic materials, the likelihood of a decrease in platelet levels increases. This effect is especially characteristic for older patients.
Simultaneous administration with chloridine increases the effect of the antimicrobial agent due to the inhibition of tetrahydroflic acid, which is involved in the formation of nucleic acids and proteins. At the same time, sulfonamides slow down the synthesis of dihydrofolic acid, which precedes the appearance of tetrahydrofolic acid compounds. This combination is used to eliminate parasitic diseases.
The absorption of the active components of Bactrim when combined with cholestyramine is reduced due to a decrease in the density in the blood substance and the synthesis of insoluble compounds.
The complex use of an antimicrobial chemical agent and antiepileptic substances increases the half-life of phenytoin with a simultaneous increase in its effect and toxicity.
The combination with antimalarial chemicals increases the risk of malignant anemia. Sulfamethoxazole and trimethoprim in combination with digoxin increase the concentration of cardiotonic. In aged patients, control over the level of antiarrhythmic substance in the blood serum should be strengthened. An antimicrobial agent reduces the effectiveness of antipsychotic therapy. When combined with cyclosporine after kidney transplantation, dysfunction of the organs of the urinary structure is observed, which is expressed by an increase in the amount of creatinine in the blood medium.
Parallel administration of Bactrim with angiotensin-converting enzyme blockers has been noted to increase the level of potassium in the blood. This is especially true for older patients.
Trimethoprim, blocking the patency of the urinary system, increases the total and maximum density of dofetilide by 103% and 93% respectively. As a result, there is an inconsistency in the processes of depolarization and repolarization of the ventricular myocardium, the occurrence of ventricular arrhythmia. Bactrim delivery in Moscow is carried out around the clock.

Special instructions

Patients in childhood are prescribed only preparations containing sulfamethoxazole with trimethoprim, which are intended for use in pediatric practice. Monitoring of the level of saturation of sulfamethoxazole in blood plasma is performed every 2-3 days before the next use. When the saturation of the active ingredient in the amount of 150 mcg / ml, therapy is stopped until the indicator drops below 120 mcg / ml.
With prolonged treatment for more than 30 days, blood tests are taken due to the risk of formation of changes in it. They are reversible with daily intake of folic acid at a dose of 3-6 mg. This does not cause violations of the antimicrobial efficacy of the drug. In the presence of an initial folate deficiency in elderly patients, the appointment of an antimicrobial agent should be performed with caution.
To prevent the formation of salts in the urine, it is necessary to maintain sufficient urination. The use of Bactrim increases the risk of allergenic or toxic side effects with reduced filtration activity of the kidneys.