What are the main side effects of belladonna. How does belladonna interact with other medications. What are the recommended dosages and warnings for using belladonna. How is belladonna used in medical treatments. What are the symptoms of belladonna allergy. How is belladonna allergy diagnosed and treated. What are the alternatives to belladonna for treating various conditions.

Understanding Belladonna and Its Uses in Medicine

Belladonna, also known as deadly nightshade, is a plant that has been used in medicine for centuries. Its name, which means “beautiful lady” in Italian, comes from its historical use as a cosmetic to dilate pupils and create a striking appearance. Today, belladonna and its alkaloids are used in various medical applications, despite their potential toxicity.

The primary active compounds in belladonna are atropine, hyoscyamine, and scopolamine. These alkaloids have anticholinergic properties, meaning they block the effects of acetylcholine, a neurotransmitter in the body. This action can lead to various therapeutic effects, but also potential side effects and risks.

Common Medical Uses of Belladonna

• Treatment of gastrointestinal disorders, such as irritable bowel syndrome and ulcerative colitis
• Management of motion sickness and vertigo
• Reduction of excessive salivation and sweating
• Dilation of pupils for eye examinations
• Treatment of certain types of poisoning, particularly organophosphate poisoning

Despite its medical applications, belladonna must be used with caution due to its potent effects and potential for toxicity. Healthcare providers carefully weigh the benefits against the risks when prescribing belladonna-containing medications.

Recognizing the Side Effects of Belladonna

While belladonna can be beneficial in certain medical situations, it’s crucial to be aware of its potential side effects. These can range from mild to severe and may occur even with proper use of the medication.

Common Side Effects

• Dry mouth and throat
• Blurred vision
• Dilated pupils
• Increased heart rate
• Constipation
• Urinary retention
• Decreased sweating
• Skin flushing

Severe Side Effects

In some cases, more serious side effects may occur, which require immediate medical attention:

• Severe allergic reactions (anaphylaxis)
• Confusion or delirium
• Hallucinations
• Seizures
• Difficulty breathing
• Irregular heartbeat

Is belladonna safe for everyone to use? No, certain groups of people should avoid belladonna or use it with extreme caution. These include pregnant or breastfeeding women, elderly individuals, and those with certain medical conditions such as glaucoma, heart problems, or urinary retention.

Belladonna Interactions: What You Need to Know

Belladonna can interact with various medications and substances, potentially leading to adverse effects or reduced efficacy of either belladonna or the interacting drug. Understanding these interactions is crucial for safe use of belladonna-containing products.

Common Drug Interactions

• Antihistamines: May increase anticholinergic effects
• Antidepressants: Particularly tricyclic antidepressants, can enhance side effects
• Antipsychotics: May increase risk of anticholinergic toxicity
• Antiparkinsonian drugs: Can potentiate anticholinergic effects
• Muscle relaxants: May increase risk of urinary retention and constipation
• Opioids: Can increase risk of severe constipation and urinary retention

How can patients minimize the risk of drug interactions? It’s essential to inform healthcare providers about all medications, supplements, and herbal products being used. This allows for proper assessment of potential interactions and adjustment of treatment plans if necessary.

Proper Dosage and Administration of Belladonna

The dosage of belladonna varies depending on the specific condition being treated, the form of the medication, and individual patient factors. It’s crucial to follow the prescribed dosage carefully to minimize risks and maximize benefits.

Common Dosage Forms

• Oral tablets or capsules
• Topical patches
• Eye drops
• Suppositories
• Injectable solutions (for medical emergencies)

What is the typical dosage range for belladonna? Dosages can vary widely, from as low as 0.1 mg to 0.6 mg of belladonna alkaloids for oral formulations. However, the exact dosage should always be determined by a healthcare provider based on the individual’s condition and response to treatment.

It’s important to note that belladonna has a narrow therapeutic index, meaning the difference between a therapeutic dose and a toxic dose is small. This underscores the importance of adhering strictly to prescribed dosages and never adjusting the dose without medical supervision.

Belladonna Allergy: Symptoms and Diagnosis

While true allergies to belladonna are rare, some individuals may experience hypersensitivity reactions to the plant or its alkaloids. Recognizing the symptoms of a potential allergic reaction is crucial for prompt treatment and prevention of serious complications.

Common Symptoms of Belladonna Allergy

• Skin rash or hives
• Itching
• Swelling, particularly of the face, tongue, or throat
• Difficulty breathing or wheezing
• Nausea and vomiting
• Dizziness or lightheadedness

How is belladonna allergy diagnosed? Diagnosis typically involves a careful review of the patient’s medical history, physical examination, and in some cases, allergy testing. Skin prick tests or blood tests may be used to detect specific antibodies related to belladonna allergy.

In severe cases or when the diagnosis is unclear, an oral challenge test may be performed under close medical supervision. This involves administering small, gradually increasing doses of the suspected allergen to observe for any allergic reactions.

Treatment Options for Belladonna Allergy

The management of belladonna allergy depends on the severity of the reaction and can range from simple avoidance to emergency medical interventions.

Mild Reactions

• Discontinuation of belladonna-containing products
• Antihistamines to relieve itching and hives
• Topical corticosteroids for skin reactions

Severe Reactions

In cases of severe allergic reactions or anaphylaxis, immediate medical attention is crucial. Treatment may include:

• Epinephrine (adrenaline) injection
• Intravenous fluids
• Oxygen therapy
• Systemic corticosteroids
• Close monitoring in a hospital setting

Can belladonna allergy be prevented? For individuals with known belladonna allergy, the best prevention is strict avoidance of belladonna and related plants. It’s important to carefully read medication labels and inform all healthcare providers about the allergy to prevent accidental exposure.

Alternatives to Belladonna in Medical Treatments

For individuals with belladonna allergy or those who cannot tolerate its side effects, several alternatives are available depending on the condition being treated.

Gastrointestinal Disorders

• Antispasmodics like dicyclomine or hyoscyamine
• Proton pump inhibitors for acid-related conditions
• Probiotics and dietary modifications

Motion Sickness

• Antihistamines such as dimenhydrinate or meclizine
• Ginger supplements
• Acupressure wristbands

Excessive Sweating

• Aluminum-based antiperspirants
• Botulinum toxin injections
• Iontophoresis treatments

What factors should be considered when choosing an alternative to belladonna? The choice of alternative treatment depends on the specific condition, the individual’s overall health, potential side effects, and personal preferences. It’s essential to work closely with a healthcare provider to determine the most appropriate alternative treatment plan.

Safety Precautions and Warnings for Belladonna Use

Given the potent nature of belladonna and its alkaloids, several safety precautions and warnings should be observed when using belladonna-containing products.

Key Warnings

• Avoid use in children unless specifically prescribed by a healthcare provider
• Do not use during pregnancy or breastfeeding without medical supervision
• Use caution in elderly patients due to increased sensitivity to side effects
• Avoid alcohol consumption while using belladonna, as it can enhance side effects
• Do not operate heavy machinery or drive until you know how belladonna affects you
• Keep belladonna products out of reach of children and pets

How should belladonna products be stored? Belladonna products should be stored in a cool, dry place, away from direct sunlight and heat. Always keep them in their original containers with labels intact to prevent accidental ingestion or misuse.

It’s crucial to dispose of unused or expired belladonna products properly. Many pharmacies offer medication take-back programs, or you can consult local waste management guidelines for safe disposal methods.

Monitoring and Follow-up

Regular monitoring is essential when using belladonna-containing medications. This may include:

• Periodic eye examinations to check for increased intraocular pressure
• Blood tests to monitor kidney and liver function
• Regular assessment of side effects and treatment efficacy
• Adjustment of dosage as needed based on response and tolerability

Patients should maintain open communication with their healthcare providers, reporting any new or worsening symptoms promptly. This allows for timely adjustments to the treatment plan and ensures the safe and effective use of belladonna-containing medications.

In conclusion, while belladonna can be a valuable therapeutic agent in certain medical conditions, its use requires careful consideration of potential risks, side effects, and interactions. By understanding these aspects and following proper precautions, patients and healthcare providers can maximize the benefits of belladonna while minimizing potential harm. As with any medication, individual response may vary, and personalized medical advice is crucial for optimal treatment outcomes.

Allergy to belladonna alkaloid (Concept Id: C0570984) – MedGen

PubMed

Inhaled magnesium sulfate in the treatment of acute asthma.

Knightly R,
Milan SJ,
Hughes R,
Knopp-Sihota JA,
Rowe BH,
Normansell R,
Powell C
Cochrane Database Syst Rev
2017 Nov 28;11(11):CD003898.
doi: 10.1002/14651858.CD003898.pub6.
PMID: 29182799Free PMC Article

Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma.

Kirkland SW,
Vandenberghe C,
Voaklander B,
Nikel T,
Campbell S,
Rowe BH
Cochrane Database Syst Rev
2017 Jan 11;1(1):CD001284.
doi: 10.1002/14651858.CD001284.pub2.
PMID: 28076656Free PMC Article

Adverse reaction to atropine and the treatment of organophosphate intoxication.

Robenshtok E,
Luria S,
Tashma Z,
Hourvitz A
Isr Med Assoc J
2002 Jul;4(7):535-9.
PMID: 12120467

See all (75)

Etiology

Combination of ipratropium bromide and salbutamol in children and adolescents with asthma: A meta-analysis.

Xu H,
Tong L,
Gao P,
Hu Y,
Wang H,
Chen Z,
Fang L
PLoS One
2021;16(2):e0237620.
Epub 2021 Feb 23
doi: 10.1371/journal.pone.0237620.
PMID: 33621253Free PMC Article

Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial.

Schuh S,
Sweeney J,
Rumantir M,
Coates AL,
Willan AR,
Stephens D,
Atenafu EG,
Finkelstein Y,
Thompson G,
Zemek R,
Plint AC,
Gravel J,
Ducharme FM,
Johnson DW,
Black K,
Curtis S,
Beer D,
Klassen TP,
Nicksy D,
Freedman SB;
Pediatric Emergency Research Canada (PERC) Network
JAMA
2020 Nov 24;324(20):2038-2047.
doi: 10.1001/jama.2020.19839.
PMID: 33231663Free PMC Article

Salbutamol and ipratropium by inhaler is superior to nebulizer in children with severe acute asthma exacerbation: Randomized clinical trial.

Iramain R,
Castro-Rodriguez JA,
Jara A,
Cardozo L,
Bogado N,
Morinigo R,
De Jesús R
Pediatr Pulmonol
2019 Apr;54(4):372-377.
Epub 2019 Jan 22
doi: 10.1002/ppul.24244.
PMID: 30672140

Inhaled magnesium sulfate in the treatment of acute asthma.

Knightly R,
Milan SJ,
Hughes R,
Knopp-Sihota JA,
Rowe BH,
Normansell R,
Powell C
Cochrane Database Syst Rev
2017 Nov 28;11(11):CD003898.
doi: 10.1002/14651858.CD003898.pub6.
PMID: 29182799Free PMC Article

Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma.

Kirkland SW,
Vandenberghe C,
Voaklander B,
Nikel T,
Campbell S,
Rowe BH
Cochrane Database Syst Rev
2017 Jan 11;1(1):CD001284.
doi: 10.1002/14651858.CD001284.pub2.
PMID: 28076656Free PMC Article

See all (272)

Diagnosis

Acute severe asthma (status asthmaticus).

Agnihotri NT,
Saltoun C
Allergy Asthma Proc
2019 Nov 1;40(6):406-409.
doi: 10.2500/aap.2019.40.4258.
PMID: 31690381

Anaphylactoid Syndrome of Pregnancy.

Barnhart ML,
Rosenbaum K
Nurs Womens Health
2019 Feb;23(1):38-48.
doi: 10.1016/j. nwh.2018.11.006.
PMID: 30738557

Asthma: 2015 and beyond.

Myers TR,
Tomasio L
Respir Care
2011 Sep;56(9):1389-407; discussion 1407-10.
doi: 10.4187/respcare.01334.
PMID: 21944687

The ‘crashing asthmatic.’.

Higgins JC
Am Fam Physician
2003 Mar 1;67(5):997-1004.
PMID: 12643359

Exercise-induced asthma.

Anderson SD,
Silverman M,
König P,
Godfrey S
Br J Dis Chest
1975 Jan;69(1):1-39.
doi: 10.1016/0007-0971(75)90053-4.
PMID: 237526

See all (159)

Therapy

Combination of ipratropium bromide and salbutamol in children and adolescents with asthma: A meta-analysis.

Xu H,
Tong L,
Gao P,
Hu Y,
Wang H,
Chen Z,
Fang L
PLoS One
2021;16(2):e0237620.
Epub 2021 Feb 23
doi: 10.1371/journal.pone.0237620.
PMID: 33621253Free PMC Article

Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial.

Schuh S,
Sweeney J,
Rumantir M,
Coates AL,
Willan AR,
Stephens D,
Atenafu EG,
Finkelstein Y,
Thompson G,
Zemek R,
Plint AC,
Gravel J,
Ducharme FM,
Johnson DW,
Black K,
Curtis S,
Beer D,
Klassen TP,
Nicksy D,
Freedman SB;
Pediatric Emergency Research Canada (PERC) Network
JAMA
2020 Nov 24;324(20):2038-2047.
doi: 10.1001/jama.2020.19839.
PMID: 33231663Free PMC Article

Acute severe asthma (status asthmaticus).

Agnihotri NT,
Saltoun C
Allergy Asthma Proc
2019 Nov 1;40(6):406-409.
doi: 10.2500/aap.2019.40.4258.
PMID: 31690381

Salbutamol and ipratropium by inhaler is superior to nebulizer in children with severe acute asthma exacerbation: Randomized clinical trial.

Iramain R,
Castro-Rodriguez JA,
Jara A,
Cardozo L,
Bogado N,
Morinigo R,
De Jesús R
Pediatr Pulmonol
2019 Apr;54(4):372-377.
Epub 2019 Jan 22
doi: 10.1002/ppul.24244.
PMID: 30672140

Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma.

Kirkland SW,
Vandenberghe C,
Voaklander B,
Nikel T,
Campbell S,
Rowe BH
Cochrane Database Syst Rev
2017 Jan 11;1(1):CD001284.
doi: 10.1002/14651858.CD001284.pub2.
PMID: 28076656Free PMC Article

See all (865)

Prognosis

Acute severe asthma (status asthmaticus).

Agnihotri NT,
Saltoun C
Allergy Asthma Proc
2019 Nov 1;40(6):406-409.
doi: 10.2500/aap.2019.40.4258.
PMID: 31690381

Inhaled magnesium sulfate in the treatment of acute asthma.

Knightly R,
Milan SJ,
Hughes R,
Knopp-Sihota JA,
Rowe BH,
Normansell R,
Powell C
Cochrane Database Syst Rev
2017 Nov 28;11(11):CD003898.
doi: 10.1002/14651858.CD003898.pub6.
PMID: 29182799Free PMC Article

Asthma in adults (acute).

Rodrigo G
BMJ Clin Evid
2011 Apr 4;2011
PMID: 21463536Free PMC Article

Effects of allergy and age on responses to salbutamol and ipratropium bromide in moderate asthma and chronic bronchitis.

van Schayck CP,
Folgering H,
Harbers H,
Maas KL,
van Weel C
Thorax
1991 May;46(5):355-9.
doi: 10.1136/thx.46.5.355.
PMID: 1829865Free PMC Article

Exercise-induced asthma.

Anderson SD,
Silverman M,
König P,
Godfrey S
Br J Dis Chest
1975 Jan;69(1):1-39.
doi: 10.1016/0007-0971(75)90053-4.
PMID: 237526

See all (118)

Clinical prediction guides

Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial.

Schuh S,
Sweeney J,
Rumantir M,
Coates AL,
Willan AR,
Stephens D,
Atenafu EG,
Finkelstein Y,
Thompson G,
Zemek R,
Plint AC,
Gravel J,
Ducharme FM,
Johnson DW,
Black K,
Curtis S,
Beer D,
Klassen TP,
Nicksy D,
Freedman SB;
Pediatric Emergency Research Canada (PERC) Network
JAMA
2020 Nov 24;324(20):2038-2047.
doi: 10.1001/jama.2020.19839.
PMID: 33231663Free PMC Article

Acute severe asthma (status asthmaticus).

Agnihotri NT,
Saltoun C
Allergy Asthma Proc
2019 Nov 1;40(6):406-409.
doi: 10.2500/aap.2019.40.4258.
PMID: 31690381

Salbutamol and ipratropium by inhaler is superior to nebulizer in children with severe acute asthma exacerbation: Randomized clinical trial.

Iramain R,
Castro-Rodriguez JA,
Jara A,
Cardozo L,
Bogado N,
Morinigo R,
De Jesús R
Pediatr Pulmonol
2019 Apr;54(4):372-377.
Epub 2019 Jan 22
doi: 10.1002/ppul.24244.
PMID: 30672140

Inhaled magnesium sulfate in the treatment of acute asthma.

Knightly R,
Milan SJ,
Hughes R,
Knopp-Sihota JA,
Rowe BH,
Normansell R,
Powell C
Cochrane Database Syst Rev
2017 Nov 28;11(11):CD003898.
doi: 10.1002/14651858.CD003898.pub6.
PMID: 29182799Free PMC Article

Response to nebulized salbutamol versus combination with ipratropium bromide in children with acute severe asthma.

Memon BN,
Parkash A,
Ahmed Khan KM,
Gowa MA,
Bai C
J Pak Med Assoc
2016 Mar;66(3):243-6.
PMID: 26968269

See all (223)

Inhaled magnesium sulfate in the treatment of acute asthma.

Knightly R,
Milan SJ,
Hughes R,
Knopp-Sihota JA,
Rowe BH,
Normansell R,
Powell C
Cochrane Database Syst Rev
2017 Nov 28;11(11):CD003898.
doi: 10.1002/14651858.CD003898.pub6.
PMID: 29182799Free PMC Article

Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma.

Kirkland SW,
Vandenberghe C,
Voaklander B,
Nikel T,
Campbell S,
Rowe BH
Cochrane Database Syst Rev
2017 Jan 11;1(1):CD001284.
doi: 10.1002/14651858.CD001284.pub2.
PMID: 28076656Free PMC Article

Asthma in adults (acute).

Rodrigo G
BMJ Clin Evid
2011 Apr 4;2011
PMID: 21463536Free PMC Article

Anticholinergic drugs for wheeze in children under the age of two years.

Everard ML,
Bara A,
Kurian M,
Elliott TM,
Ducharme F,
Mayowe V
Cochrane Database Syst Rev
2005 Jul 20;2005(3):CD001279.
doi: 10.1002/14651858.CD001279.pub2.
PMID: 16034861Free PMC Article

Anticholinergic drugs for wheeze in children under the age of two years.

Everard ML,
Bara A,
Kurian M,
Elliott TM,
Ducharme F
Cochrane Database Syst Rev
2002;(1):CD001279.
doi: 10.1002/14651858.CD001279.
PMID: 11869598

See all (11)

Belladonna: Uses and risks

Despite being a very poisonous plant, people have used belladonna in many different ways throughout history.

While it has been used as a poison in the past, scientists today extract chemicals from belladonna for use in medicine. These chemicals, when used under a doctor’s supervision, can treat a range of afflictions, from excessive urination at night to irritable bowel syndrome (IBS).

Share on PinterestThe belladonna plant may also be called deadly nightshade.

Belladonna (Atropa belladonna) is a poisonous plant, native to parts of Asia and Europe. It is sometimes known as deadly nightshade.

Belladonna produces small, black berries that must not be eaten. Eating the berries or leaves can be deadly. Similar to poison ivy, a person whose skin comes into direct contact with the leaves may develop a rash.

In ancient times, people used belladonna for its toxic properties, as an oral poison or on the tips of arrows.

Some scholars believe that Shakespeare referenced belladonna in his play, “Romeo and Juliet.” It is possible that belladonna was the poison that Juliet drank to fake her death.

As time progressed, people used belladonna for cosmetic and medicinal purposes. For example, doctors used it as an antiseptic before surgery in medieval Europe.

During the Italian Renaissance, which lasted from the 14th to 16th century, fashionable women drank the juice of belladonna berries to dilate their pupils. Belladonna owes its name to this practice, as it means “beautiful woman” in Italian.

In modern times, optometrists often use belladonna to help dilate pupils when examining a person’s eyes.

Other recent uses of belladonna include over-the-counter creams and other herbal supplements. Despite its commercial availability, people are strongly advised to use belladonna with caution and under a doctor’s care.

When used correctly in appropriate doses, belladonna is safe to use as part of regular medicinal practices.

It is important to note that ingesting even small amounts of the leaves or berries can be deadly. Small children and infants are particularly at risk. Be sure to use caution when storing medicines that contain belladonna.

Scopolamine and atropine

Share on PinterestBelladonna contains chemicals used to treat conditions such as irritable bowel syndrome.

Belladonna contains two chemicals used for medicinal purposes.

The first chemical is scopolamine, which is used primarily for reducing body discharges. It is also helpful in reducing stomach acid, which can help with both nausea and acid reflux.

Scopolamine is also used for controlling the heart rate and relaxing muscles.

The second compound extracted from belladonna is atropine. Similar to scopolamine, atropine can be used to help reduce bodily discharge, but it is not as effective as scopolamine when used as a muscle relaxant and in heart rate control.

Also, atropine can be used to dilate the eyes. In some cases, atropine works as an antidote to insect poison and chemical warfare agents.

Once extracted, one or both chemicals are combined with other medications to help treat some diseases and conditions.

Some of the treatments target:

• motion sickness
• irritable bowel syndrome
• stomach ulcers
• excessive nighttime urination
• diverticulitis
• Parkinson’s disease
• pink eye

When taken as part of a prescribed medication, belladonna is considered mostly safe. Like all medicines, it can have side effects, and people should consider its use very carefully.

As with any potentially harmful medication, it is best to speak to a doctor before using a product containing belladonna.

Like many well-known plants and extracts, belladonna is available in some over-the-counter alternative medications and supplements.

Unlike traditional medicines, the U.S. Food and Drug Administration (FDA) do not regulate supplements, which means they are often not tested for safety or the effectiveness of their claimed outcomes.

Companies that have made products containing belladonna state that it can improve various conditions. These include:

• the common cold
• fever
• whooping cough
• hay fever
• earache
• asthma
• motion sickness
• flu
• a cough and sore throat
• joint and back pain
• arthritis pain
• spasms, or colic-like pain in the stomach or bile ducts
• nerve problems
• gout
• inflammation
• Parkinson’s disease
• hemorrhoids

Belladonna is an ingredient in creams, some liquids, ointments, and, in some cases, suppositories.

There is little research into belladonna’s effectiveness at treating any of the above conditions. It is important to consider the potential side effects before taking belladonna as a supplement.

Share on PinterestBlurred vision and hallucinations are potential side effects of belladonna.

Belladonna is considered a toxic plant with historical uses as a poison. Despite being sold as an over-the-counter supplement, it is likely not safe to consume. It is also important to be aware that the FDA do not monitor the quality and purity of belladonna supplements.

There are some side effects to consider before using belladonna. These side effects include:

• dry mouth
• red, dry skin
• inability to sweat
• muscle spasms
• blurred vision
• enlarged pupils
• hallucinations
• inability to urinate
• convulsions
• seizures
• coma

Women who are pregnant or breastfeeding may be at additional risk, as some of belladonna’s side effects may appear in the unborn child, and it might dry up milk production.

In addition to the side effects, belladonna may make some conditions worse. These include disorders that some manufacturers claim belladonna helps.

Conditions that belladonna can make worse include:

• acid reflux
• fever
• rapid heartbeat
• gastrointestinal (GI) tract infections
• high blood pressure
• constipation
• urination problems

Belladonna has negative interactions with certain medications as well, such as those for allergies and depression. Side effects of the interaction include a rapid heartbeat and rashes.

Belladonna can be a safe herbal supplement or part of medication but only when used properly under a doctor’s care and supervision. There are a number of side effects that should be considered before using belladonna as a supplement.

Additional research needs to be conducted to test the effectiveness of belladonna alongside the risks. Individuals should carefully consider their options before trying belladonna as a replacement or supplemental treatment.

Belladonna and Opium: Pediatric Medication

Pediatric Medicine

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Provided by Lexicomp ^® , this document contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Warning

• This drug is a strong pain reliever that may put your child at risk for addiction, abuse, or misuse of this drug. Misuse or abuse of this drug can lead to overdose and death. Check with your child’s doctor.
• Your child will be closely monitored to avoid misuse, abuse, or dependence on this drug.
• This drug can cause very serious and sometimes deadly breathing problems. If your child has slow, shallow, or difficult breathing, contact your doctor immediately.
• The risk of very serious and sometimes deadly breathing problems may be increased when your child starts this drug or if the dose is increased. Check with your child’s doctor.
• Even one dose of this drug, taken by another person or by mistake, can be deadly, especially in children. If this drug has been taken by another person or by mistake, get medical help right away.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• This drug contains an opioid. Serious side effects have occurred when using opioids with benzodiazepines, alcohol, marijuana, or other forms of cannabis, as well as prescription or over-the-counter drugs that can cause drowsiness or slow action. These effects include slow or labored breathing and death. Benzodiazepines include drugs such as alprazolam, diazepam, and lorazepam. Benzodiazepines can be used to treat many health conditions such as anxiety, sleep disorders, or seizures. If you have any questions, please consult your doctor.
• Many drugs interact with this drug and may increase the risk of side effects such as life-threatening breathing problems. Check with your doctor and pharmacist to make sure it is safe to use this drug with all your other drugs.
• Make sure your child does not consume alcohol or products containing alcohol. Dangerous, sometimes deadly, effects may develop.
• Seek immediate medical attention if your child does not respond, does not respond, or does not react in the usual way, feels very drowsy or dizzy, passes out, or if he sleeps and does not wake up.

If your daughter is pregnant:

• Long-term use of this drug during pregnancy may cause withdrawal symptoms in the newborn. This can be life threatening. Consult your doctor.

What is this drug used for?

• It is used to relieve pain that occurs with certain muscle spasms in the urinary tract.

What should I tell the doctor BEFORE my child takes this drug?

• If your child has an allergy to this drug, any of its ingredients, other drugs, foods, or substances. Tell the doctor about the allergy and how it manifested itself in the child.
• If your child has any of the following health conditions: severe reactions to opioid drugs, preterm labor, glaucoma, kidney or liver disease, seizures.
• If your child has any of these health conditions: Lung or breathing problems such as asthma, shortness of breath, or sleep apnea; high levels of carbon dioxide in the blood, gastrointestinal obstruction or narrowing.
• If your child currently has alcohol withdrawal.
• If your child has recently consumed large amounts of alcohol.
• If your child has taken medications for depression or certain other illnesses in the last 14 days. These include isocarboxazid, phenelzine, and tranylcypromine. An episode of very high blood pressure may occur.
• If your child is taking any of the following drugs: buprenorphine, butorphanol, linezolid, methylene blue, nalbuphine, or pentazocine.
• If the patient is a child under 12 years of age. Do not give this drug to children under 12 years of age.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Talk to your doctor or pharmacist about all medicines your child is taking (prescription and over-the-counter, natural, and vitamins) and any health problems. You need to make sure that this drug is safe to use for your child’s illnesses and in combination with other drugs he or she is already taking. Do not start, stop taking, or change the dosage of any drug your child is taking without the doctor’s approval.

What do I need to know or do while my child is taking this drug?

• Tell all health care providers who care for your child that your child is taking this drug. These are your child’s doctors, nurses, pharmacists and dentists.
• Have your child avoid tasks or activities that require attention until you see how this drug works for your child. This includes cycling, playing sports, or using items such as scissors, lawn mowers, electric scooters, toy cars, or motorized vehicles.
• To reduce the risk of dizziness or fainting, have your child get up slowly from a sitting or lying position. Make sure your child goes up and down the stairs carefully.
• Do not exceed the dose prescribed by your doctor. Do not use the drug more often or for longer than recommended. Violation of the instructions for taking the drug may increase the risk of serious side effects.
• If your child uses this drug for a long time or at high doses, it may not work as well and a higher dose may be needed to get the desired effect. The patient develops a so-called tolerance to the drug. Call your doctor if this drug stops working as you want. Do not give your child higher doses of this drug than the doctor has prescribed.
• Long-term or regular use of opioid medications like this can lead to addiction. Reducing the dose or stopping this drug suddenly can cause a serious risk of withdrawal reactions or other serious problems. Check with your child’s doctor before reducing the dose or stopping this drug. You must follow the doctor’s instructions. Tell your child’s doctor if your child has severe pain, mood changes, suicidal thoughts, or any other side effects.
• This drug may increase the risk of seizures in some people, including people who have had seizures in the past. Check with your doctor to find out if your child is at increased risk of seizures while taking this drug.
• Bright light can irritate the child. Make sure your child wears sunglasses.
• Do not give this drug with other strong pain medicines or if you are using a pain patch without talking to your child’s doctor first.

If your daughter is pregnant or breastfeeding:

• If your daughter takes this medicine during pregnancy, it could harm the fetus. If your daughter is pregnant or becomes pregnant while taking this drug, call your doctor right away.
• If your daughter is breastfeeding, tell your daughter’s doctor. This drug passes into breast milk and may harm your daughter’s baby.

What side effects should I report to my child’s doctor right away?

WARNING/CAUTION: Although rare, some people may have very serious and sometimes deadly side effects of this drug. Call your child’s doctor right away or get medical help if your child has any of the following signs or symptoms that could be associated with a very bad side effect:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Labored, slow or shallow breathing.
• Breathing disorders during sleep (sleep apnea syndrome).
• Noisy breathing.
• Severe dizziness or fainting.
• Severe constipation or abdominal pain. These may be signs of a severe bowel disorder.
• Seizures.
• Pain or pressure in the chest or a fast heartbeat.
• Confusion of consciousness.
• Obstruction of the urinary tract.
• Blurred vision.
• If bright light irritates your child’s eyes.
• Difficulties with walking.
• If your child takes this drug with other drugs, a bad and sometimes deadly condition called serotonin syndrome can develop. Call your child’s healthcare provider right away if your child has agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythm, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting, severe headache.
• Taking opioid pain medications like this can cause a rare but severe adrenal disorder. If your child feels very tired or weak, passes out, or has severe dizziness, severe nausea, vomiting, or loss of appetite, call their healthcare provider right away.
• Long-term use of an opioid medicine can lead to a decrease in the level of sex hormones. If your child has a decreased interest in sex, fertility problems, no menstruation, or problems with ejaculation, see your doctor.

What are some other side effects of this drug?

Any drug can cause side effects. However, for many people, side effects are either minor or non-existent. Contact your child’s doctor or seek medical attention if any of these or other side effects bother your child or if they persist:

• Feeling dizzy, drowsy, tired or weak.
• Dry mouth.
• Nausea or vomiting.
• Constipation.
• Headache.
• Pain in the intestines.

This list of possible side effects is not exhaustive. If you have any questions about side effects, ask your child’s doctor. Talk to your child’s doctor about side effects.

You can report side effects to the National Health Board.

What is the best way to give this drug?

Give this drug to your child as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

• Apply the suppository to the rectum.
• Before use, remove the foil wrapper and moisten the candle with cold water. Ask the child to lie on their side. Using your finger, insert the suppository into the rectum at the optimal distance.

What if my child misses a dose of medication?

• If your child takes the drug regularly, give the missed dose as soon as you remember it.
• If it is time for your child to take the next dose, do not take the missed dose and then go back to your child’s normal schedule.
• Do not give a double dose at the same time or additional doses.
• In most cases, this drug is used as needed. Do not give your child the drug more often than prescribed by the doctor.

How do I store and/or discard this drug?

• Store at room temperature. Do not place in refrigerator or freezer.
• Store in a dry place. Do not store in the bathroom.
• Keep this medicine in a protected place out of sight and reach of children and out of the reach of other people. A box or room that is locked with a key can act as a secure storage place for the drug. Keep all medicines out of the reach of pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General information about medicines

• If your child’s symptoms or health problems do not improve, or worsen, contact your child’s doctor.
• Do not share your child’s medicine with others and do not give anyone else’s medicine to your child.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your child’s doctor, nurse, pharmacist, or other health care professional.
• An overdose of this drug can be treated with the drug naloxone. Your child’s doctor may prescribe naloxone to keep with you while your child takes this drug. Talk to your doctor or pharmacist if you have any questions about the use of this drug in your child. If you think you have overdosed, call a poison control center or get medical help right away, even after using naloxone. Be prepared to tell or show what drug was taken, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2022-07-08

Copyright

© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

Allergosan granules 20 g

Producer

Homeopharm

Product form

granules 20 g

Composition

Apis C 3, Belladonna C3, Fragaria C 3, Urtica C3.

Indications

skin itching of various etiologies, angioedema, cold allergy, food allergy, dermatitis, eczema, urticaria, bronchial asthma (as part of complex therapy), vasomotor rhinitis, allergic rhinitis, hay fever, allergic manifestations of flowering, allergic dermatitis

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How to use

The combination of components allows the use of Allergosan as a basic or main drug in acute conditions accompanied by an allergic component. Successfully implements humoral and tissue components of acute allergic reactions in: hay fevers, allergic rhinitis (hay fever) – spring and summer allergies to flowering. At the same time, treatment begins at least 3 months before flowering (course treatment) 1 granule per day, going into an exacerbation period up to 3-5 granules 2-3 times a day, with breaks of 1-2 days a week.

If there are acute reactions (swelling, mucosal hyperemia, rash) to a sudden irritant (dust, pungent odors and other allergens), you can take 3-4 times 1-3 granules until the allergic reaction stops (single doses) every 10-15 minutes until symptoms change, then less often – after 1-2 hours or after 3-4 hours until improvement.

In chronic processes – for a long time 3 granules 20-30 minutes before meals.

For rashes on the skin or mucous membranes, it is recommended to combine with local application of Allergin ointment.

Cannot be combined on the same day with Faringosan and Artrosan.

For allergic rashes or asthmatic conditions, an additional monocomponent homeopathic treatment may be required.

May be combined with other medical treatment (allopathic) during an exacerbation.

Locally, Allergin or Graphite ointments can be applied.

The drug is even more effective when combined with monocomponent drugs Astacus C3, Medusa C3, Hotarus C3.

Since a frequent cause of the development of allergic conditions are disorders in the work of the gastrointestinal tract, Laxatin, Dysbacteriosin, Fungisan, Helmintosan, Ulkusan in combination with Pancreasan, Hepatocholin – according to indications can be prescribed. (See also Dermadipin).

Description

ALLERGOSAN is a complex homeopathic preparation.

Therapeutic action: antiallergic, desensitizing, antiedematous, antispasmodic.

Indications for the use of the components of the complex:

1. APIS MELLIFICA – Apis C3, (Honey bee in breeding 10 – 6).

– Anti-inflammatory, decongestant, desensitizing, antiallergic.

– Action on the skin and mucous membranes, lymph.

– All diseases accompanied by edema: edema with stabbing pains, burning, sensitive to touch in the absence of thirst, tonsillitis, tonsillitis, urticaria; diseases accompanied by accumulation of fluid in tissues or cavities: ovarian cysts, dropsy tumors of renal origin, serous discharge during pleurisy, conjunctivitis, panaritium; symptoms of irritation, inflammation of the brain and meninges; kidney disease, nephritis after hemorrhagic fever and scarlet fever, erysipelas (especially on the face).

2. ANTIMONIUM CRUDUM – Antimon. crud. C12 (Black sulphurous antimony in intelligence 10-24)

– Cold and food allergy;

– Food allergy with indigestion and gastritis with feeling of fullness, heaviness in the stomach; with aversion to food, white coating of the tongue, burning in the rectum.

– Skin lesions: weeping eczema, fissures, keratinization, calluses, brittle nails.

– Roughness of the skin from cold, with cracks.

3. BELLADONNA – Belladonna C3, (Beauty. Belladonna at a dilution of 10 -6)

– Anti-inflammatory, anti-spastic, anti-allergic agent that regulates vasomotor disorders.

– Action on the nervous lymphatic system, mucous membranes, skin, tissue.

4. FRAGARIA – Fragaria C3, (Wild strawberry in breeding 10 – 6).

– Food, cold allergy, urticaria.

– Promotes the elimination of homotoxins in chronic diseases accompanied by auto-immune processes (gout, diseases of the liver, spleen, kidneys, atherosclerosis).