What are the key aspects of belladonna allergy. How does belladonna affect the body. What are the common side effects and interactions of belladonna. How is belladonna allergy diagnosed and treated. What precautions should be taken when using belladonna.

Understanding Belladonna and Its Alkaloids

Belladonna, also known as deadly nightshade, is a plant that has been used for centuries in medicine and as a poison. Its name, which means “beautiful lady” in Italian, comes from its historical use as a cosmetic to dilate pupils and create a luminous appearance. However, belladonna’s beauty is deceptive, as it contains potent alkaloids that can have significant effects on the human body.

The primary alkaloids found in belladonna are:

• Atropine
• Hyoscyamine
• Scopolamine

These compounds are known as anticholinergics, which means they block the action of acetylcholine, a neurotransmitter responsible for various functions in the body. This blocking action is what gives belladonna its medicinal properties, but it’s also the source of its potential for toxicity and allergic reactions.

Belladonna Allergy: Symptoms and Manifestations

An allergy to belladonna or its alkaloids can manifest in various ways. The symptoms can range from mild to severe and may include:

• Skin rashes or hives
• Itching
• Swelling, particularly of the face, tongue, or throat
• Difficulty breathing or wheezing
• Nausea and vomiting
• Dizziness or confusion
• Rapid heartbeat

In severe cases, a belladonna allergy can lead to anaphylaxis, a potentially life-threatening allergic reaction that requires immediate medical attention.

Can belladonna allergy be confused with its side effects?

Yes, distinguishing between an allergic reaction and the side effects of belladonna can be challenging. Many of the symptoms overlap, as both are related to the body’s response to the alkaloids. However, allergic reactions typically occur rapidly after exposure and may involve the immune system, while side effects are usually dose-dependent and related to the drug’s pharmacological action.

Side Effects and Interactions of Belladonna

Even when not experiencing an allergic reaction, belladonna and its alkaloids can cause numerous side effects due to their anticholinergic properties. Common side effects include:

• Dry mouth and throat
• Blurred vision
• Increased heart rate
• Constipation
• Urinary retention
• Decreased sweating
• Hyperthermia

Belladonna can interact with various medications, particularly those that also have anticholinergic effects. These interactions can lead to increased side effects or reduced efficacy of one or both drugs.

What medications commonly interact with belladonna?

Medications that may interact with belladonna include:

• Other anticholinergic drugs (e.g., some antihistamines, antidepressants, and antipsychotics)
• Certain antispasmodics
• Some Parkinson’s disease medications
• Certain antiemetics
• Some medications for overactive bladder

It’s crucial to inform healthcare providers about all medications, including over-the-counter drugs and herbal supplements, to avoid potential interactions with belladonna or its alkaloids.

Medicinal Uses of Belladonna

Despite its potential for toxicity and allergic reactions, belladonna and its alkaloids have several medicinal uses. These include:

1. Treatment of gastrointestinal disorders such as irritable bowel syndrome and ulcerative colitis
2. Management of motion sickness
3. Dilation of pupils for eye examinations
4. Control of excessive salivation and drooling
5. Treatment of certain types of bradycardia (slow heart rate)
6. Management of symptoms in Parkinson’s disease
7. Alleviation of symptoms in chronic obstructive pulmonary disease (COPD)

The use of belladonna in medicine is carefully controlled due to its potent effects and potential for toxicity. It’s typically administered in small doses and under close medical supervision.

Diagnosis of Belladonna Allergy

Diagnosing a belladonna allergy can be challenging due to the overlap between allergic symptoms and side effects. Healthcare providers typically use a combination of methods to make a diagnosis:

• Medical history: Detailed information about symptoms, timing of onset, and any previous reactions to medications or plants.
• Physical examination: To assess visible symptoms and overall health status.
• Skin tests: Patch tests or intradermal tests may be used to check for allergic reactions to belladonna or its components.
• Blood tests: These can detect specific antibodies related to belladonna allergy.
• Provocation tests: In some cases, controlled exposure to small amounts of the substance may be used to confirm an allergy, but this is done with extreme caution and only in specialized settings.

How accurate are allergy tests for belladonna?

While allergy tests can be helpful, they are not always definitive for belladonna allergy. False positives and false negatives can occur. The interpretation of test results should always be done in conjunction with the patient’s clinical history and symptoms. In some cases, a diagnosis may be made based on a clear history of reactions and the exclusion of other potential causes.

Treatment and Management of Belladonna Allergy

The primary approach to managing a belladonna allergy is avoidance of the allergen. However, in cases of accidental exposure or when symptoms occur, treatment may include:

1. Antihistamines: To reduce allergic symptoms such as itching and hives.
2. Corticosteroids: For more severe allergic reactions, oral or intravenous corticosteroids may be used to reduce inflammation and alleviate symptoms.
3. Epinephrine: In cases of anaphylaxis, immediate administration of epinephrine is crucial.
4. Supportive care: This may include intravenous fluids, oxygen therapy, and monitoring of vital signs.

For individuals with known belladonna allergy, carrying an epinephrine auto-injector (such as an EpiPen) may be recommended for emergency use in case of accidental exposure.

Can desensitization therapy be used for belladonna allergy?

Desensitization therapy, which involves gradually exposing an individual to increasing amounts of an allergen to reduce sensitivity, is not typically used for belladonna allergy. The risks associated with belladonna’s potent effects make this approach too dangerous. Instead, strict avoidance is the primary strategy for managing this allergy.

Precautions and Warnings for Belladonna Use

Given the potent nature of belladonna and its alkaloids, several precautions should be observed:

• Prescription only: Belladonna should only be used under the direct supervision of a healthcare provider.
• Accurate dosing: Precise dosing is crucial, as the therapeutic window is narrow.
• Monitoring: Regular monitoring for side effects and signs of toxicity is essential.
• Special populations: Extra caution is needed in children, elderly patients, and those with certain medical conditions such as glaucoma, urinary retention, or cardiovascular disease.
• Pregnancy and breastfeeding: Belladonna should be avoided during pregnancy and breastfeeding unless the potential benefits clearly outweigh the risks.
• Drug interactions: Healthcare providers should be informed of all medications and supplements to avoid potential interactions.

Are there any natural alternatives to belladonna?

While there are some herbal remedies that may have similar effects to belladonna, it’s important to note that “natural” doesn’t always mean safe. Some alternatives that have been used for similar purposes include:

• Peppermint for gastrointestinal issues
• Ginger for motion sickness
• Chamomile for relaxation and digestive health

However, these alternatives should also be used with caution and under the guidance of a healthcare provider, as they can have their own side effects and interactions.

Recent Research and Developments in Belladonna Use

While belladonna has a long history of medicinal use, research continues to explore its potential applications and risks. Recent studies have focused on:

1. Improved formulations: Developing new delivery methods to minimize side effects and improve efficacy.
2. Combination therapies: Investigating the use of belladonna alkaloids in combination with other drugs for conditions such as asthma and COPD.
3. Genetic factors: Exploring genetic variations that may influence individual responses to belladonna and its alkaloids.
4. Novel applications: Investigating potential new uses for belladonna alkaloids in areas such as neurodegenerative diseases and pain management.

These ongoing research efforts aim to enhance our understanding of belladonna’s therapeutic potential while minimizing its risks.

What are the latest findings on belladonna’s role in asthma treatment?

Recent studies have explored the use of belladonna alkaloids, particularly ipratropium (a derivative of atropine), in combination with other drugs for asthma treatment. A meta-analysis published in PLoS One in 2021 found that the combination of ipratropium bromide and salbutamol was more effective than salbutamol alone in treating children and adolescents with asthma. This combination therapy showed improvements in lung function and reduced the need for additional medications.

Another study published in JAMA in 2020 investigated the addition of nebulized magnesium to albuterol for children with refractory acute asthma in emergency departments. While this study didn’t directly involve belladonna alkaloids, it highlights the ongoing research into combination therapies for asthma, which may inform future uses of belladonna-derived medications.

Legal and Regulatory Status of Belladonna

The legal and regulatory status of belladonna and its alkaloids varies by country and specific formulation. In general:

• Pharmaceutical preparations: Medications containing belladonna alkaloids are typically regulated as prescription drugs.
• Raw plant material: The cultivation and possession of belladonna plants may be restricted or prohibited in some jurisdictions due to their potential for abuse.
• Homeopathic preparations: In some countries, highly diluted belladonna preparations are available over-the-counter as homeopathic remedies, though their efficacy is debated.
• Research use: Use of belladonna and its alkaloids in research is typically subject to strict controls and oversight.

Regulations may change over time as new research emerges and public health priorities shift. It’s important for healthcare providers and patients to stay informed about current regulations in their jurisdiction.

How do regulatory bodies ensure the safe use of belladonna-containing products?

Regulatory agencies such as the FDA in the United States and the EMA in Europe employ several strategies to ensure the safe use of belladonna-containing products:

• Strict manufacturing standards to ensure consistent potency and purity
• Required safety and efficacy studies before approval
• Mandated labeling with clear warnings and usage instructions
• Post-market surveillance to monitor for adverse events
• Ability to issue recalls or revoke approvals if safety concerns arise

These measures aim to balance the therapeutic benefits of belladonna-derived medications with the need to protect public health.

Allergy to belladonna alkaloid (Concept Id: C0570984) – MedGen

PubMed

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Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial.

Schuh S,
Sweeney J,
Rumantir M,
Coates AL,
Willan AR,
Stephens D,
Atenafu EG,
Finkelstein Y,
Thompson G,
Zemek R,
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PMID: 33231663Free PMC Article

Salbutamol and ipratropium by inhaler is superior to nebulizer in children with severe acute asthma exacerbation: Randomized clinical trial.

Iramain R,
Castro-Rodriguez JA,
Jara A,
Cardozo L,
Bogado N,
Morinigo R,
De Jesús R
Pediatr Pulmonol
2019 Apr;54(4):372-377.
Epub 2019 Jan 22
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PMID: 30672140

Inhaled magnesium sulfate in the treatment of acute asthma.

Knightly R,
Milan SJ,
Hughes R,
Knopp-Sihota JA,
Rowe BH,
Normansell R,
Powell C
Cochrane Database Syst Rev
2017 Nov 28;11(11):CD003898.
doi: 10.1002/14651858.CD003898.pub6.
PMID: 29182799Free PMC Article

Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma.

Kirkland SW,
Vandenberghe C,
Voaklander B,
Nikel T,
Campbell S,
Rowe BH
Cochrane Database Syst Rev
2017 Jan 11;1(1):CD001284.
doi: 10.1002/14651858.CD001284.pub2.
PMID: 28076656Free PMC Article

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Therapy

Combination of ipratropium bromide and salbutamol in children and adolescents with asthma: A meta-analysis.

Xu H,
Tong L,
Gao P,
Hu Y,
Wang H,
Chen Z,
Fang L
PLoS One
2021;16(2):e0237620.
Epub 2021 Feb 23
doi: 10.1371/journal.pone.0237620.
PMID: 33621253Free PMC Article

Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial.

Schuh S,
Sweeney J,
Rumantir M,
Coates AL,
Willan AR,
Stephens D,
Atenafu EG,
Finkelstein Y,
Thompson G,
Zemek R,
Plint AC,
Gravel J,
Ducharme FM,
Johnson DW,
Black K,
Curtis S,
Beer D,
Klassen TP,
Nicksy D,
Freedman SB;
Pediatric Emergency Research Canada (PERC) Network
JAMA
2020 Nov 24;324(20):2038-2047.
doi: 10.1001/jama.2020.19839.
PMID: 33231663Free PMC Article

Acute severe asthma (status asthmaticus).

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Saltoun C
Allergy Asthma Proc
2019 Nov 1;40(6):406-409.
doi: 10.2500/aap.2019.40.4258.
PMID: 31690381

Salbutamol and ipratropium by inhaler is superior to nebulizer in children with severe acute asthma exacerbation: Randomized clinical trial.

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Castro-Rodriguez JA,
Jara A,
Cardozo L,
Bogado N,
Morinigo R,
De Jesús R
Pediatr Pulmonol
2019 Apr;54(4):372-377.
Epub 2019 Jan 22
doi: 10.1002/ppul.24244.
PMID: 30672140

Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma.

Kirkland SW,
Vandenberghe C,
Voaklander B,
Nikel T,
Campbell S,
Rowe BH
Cochrane Database Syst Rev
2017 Jan 11;1(1):CD001284.
doi: 10.1002/14651858.CD001284.pub2.
PMID: 28076656Free PMC Article

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Prognosis

Acute severe asthma (status asthmaticus).

Agnihotri NT,
Saltoun C
Allergy Asthma Proc
2019 Nov 1;40(6):406-409.
doi: 10.2500/aap.2019.40.4258.
PMID: 31690381

Inhaled magnesium sulfate in the treatment of acute asthma.

Knightly R,
Milan SJ,
Hughes R,
Knopp-Sihota JA,
Rowe BH,
Normansell R,
Powell C
Cochrane Database Syst Rev
2017 Nov 28;11(11):CD003898.
doi: 10.1002/14651858.CD003898.pub6.
PMID: 29182799Free PMC Article

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Godfrey S
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1975 Jan;69(1):1-39.
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Clinical prediction guides

Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial.

Schuh S,
Sweeney J,
Rumantir M,
Coates AL,
Willan AR,
Stephens D,
Atenafu EG,
Finkelstein Y,
Thompson G,
Zemek R,
Plint AC,
Gravel J,
Ducharme FM,
Johnson DW,
Black K,
Curtis S,
Beer D,
Klassen TP,
Nicksy D,
Freedman SB;
Pediatric Emergency Research Canada (PERC) Network
JAMA
2020 Nov 24;324(20):2038-2047.
doi: 10.1001/jama.2020.19839.
PMID: 33231663Free PMC Article

Acute severe asthma (status asthmaticus).

Agnihotri NT,
Saltoun C
Allergy Asthma Proc
2019 Nov 1;40(6):406-409.
doi: 10.2500/aap.2019.40.4258.
PMID: 31690381

Salbutamol and ipratropium by inhaler is superior to nebulizer in children with severe acute asthma exacerbation: Randomized clinical trial.

Iramain R,
Castro-Rodriguez JA,
Jara A,
Cardozo L,
Bogado N,
Morinigo R,
De Jesús R
Pediatr Pulmonol
2019 Apr;54(4):372-377.
Epub 2019 Jan 22
doi: 10.1002/ppul.24244.
PMID: 30672140

Inhaled magnesium sulfate in the treatment of acute asthma.

Knightly R,
Milan SJ,
Hughes R,
Knopp-Sihota JA,
Rowe BH,
Normansell R,
Powell C
Cochrane Database Syst Rev
2017 Nov 28;11(11):CD003898.
doi: 10.1002/14651858.CD003898.pub6.
PMID: 29182799Free PMC Article

Response to nebulized salbutamol versus combination with ipratropium bromide in children with acute severe asthma.

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Knightly R,
Milan SJ,
Hughes R,
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Rowe BH,
Normansell R,
Powell C
Cochrane Database Syst Rev
2017 Nov 28;11(11):CD003898.
doi: 10.1002/14651858.CD003898.pub6.
PMID: 29182799Free PMC Article

Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma.

Kirkland SW,
Vandenberghe C,
Voaklander B,
Nikel T,
Campbell S,
Rowe BH
Cochrane Database Syst Rev
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BMJ Clin Evid
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Belladonna: Uses and risks

Despite being a very poisonous plant, people have used belladonna in many different ways throughout history.

While it has been used as a poison in the past, scientists today extract chemicals from belladonna for use in medicine. These chemicals, when used under a doctor’s supervision, can treat a range of afflictions, from excessive urination at night to irritable bowel syndrome (IBS).

Share on PinterestThe belladonna plant may also be called deadly nightshade.

Belladonna (Atropa belladonna) is a poisonous plant, native to parts of Asia and Europe. It is sometimes known as deadly nightshade.

Belladonna produces small, black berries that must not be eaten. Eating the berries or leaves can be deadly. Similar to poison ivy, a person whose skin comes into direct contact with the leaves may develop a rash.

In ancient times, people used belladonna for its toxic properties, as an oral poison or on the tips of arrows.

Some scholars believe that Shakespeare referenced belladonna in his play, “Romeo and Juliet.” It is possible that belladonna was the poison that Juliet drank to fake her death.

As time progressed, people used belladonna for cosmetic and medicinal purposes. For example, doctors used it as an antiseptic before surgery in medieval Europe.

During the Italian Renaissance, which lasted from the 14th to 16th century, fashionable women drank the juice of belladonna berries to dilate their pupils. Belladonna owes its name to this practice, as it means “beautiful woman” in Italian.

In modern times, optometrists often use belladonna to help dilate pupils when examining a person’s eyes.

Other recent uses of belladonna include over-the-counter creams and other herbal supplements. Despite its commercial availability, people are strongly advised to use belladonna with caution and under a doctor’s care.

When used correctly in appropriate doses, belladonna is safe to use as part of regular medicinal practices.

It is important to note that ingesting even small amounts of the leaves or berries can be deadly. Small children and infants are particularly at risk. Be sure to use caution when storing medicines that contain belladonna.

Scopolamine and atropine

Share on PinterestBelladonna contains chemicals used to treat conditions such as irritable bowel syndrome.

Belladonna contains two chemicals used for medicinal purposes.

The first chemical is scopolamine, which is used primarily for reducing body discharges. It is also helpful in reducing stomach acid, which can help with both nausea and acid reflux.

Scopolamine is also used for controlling the heart rate and relaxing muscles.

The second compound extracted from belladonna is atropine. Similar to scopolamine, atropine can be used to help reduce bodily discharge, but it is not as effective as scopolamine when used as a muscle relaxant and in heart rate control.

Also, atropine can be used to dilate the eyes. In some cases, atropine works as an antidote to insect poison and chemical warfare agents.

Once extracted, one or both chemicals are combined with other medications to help treat some diseases and conditions.

Some of the treatments target:

• motion sickness
• irritable bowel syndrome
• stomach ulcers
• excessive nighttime urination
• diverticulitis
• Parkinson’s disease
• pink eye

When taken as part of a prescribed medication, belladonna is considered mostly safe. Like all medicines, it can have side effects, and people should consider its use very carefully.

As with any potentially harmful medication, it is best to speak to a doctor before using a product containing belladonna.

Like many well-known plants and extracts, belladonna is available in some over-the-counter alternative medications and supplements.

Unlike traditional medicines, the U.S. Food and Drug Administration (FDA) do not regulate supplements, which means they are often not tested for safety or the effectiveness of their claimed outcomes.

Companies that have made products containing belladonna state that it can improve various conditions. These include:

• the common cold
• fever
• whooping cough
• hay fever
• earache
• asthma
• motion sickness
• flu
• a cough and sore throat
• joint and back pain
• arthritis pain
• spasms, or colic-like pain in the stomach or bile ducts
• nerve problems
• gout
• inflammation
• Parkinson’s disease
• hemorrhoids

Belladonna is an ingredient in creams, some liquids, ointments, and, in some cases, suppositories.

There is little research into belladonna’s effectiveness at treating any of the above conditions. It is important to consider the potential side effects before taking belladonna as a supplement.

Share on PinterestBlurred vision and hallucinations are potential side effects of belladonna.

Belladonna is considered a toxic plant with historical uses as a poison. Despite being sold as an over-the-counter supplement, it is likely not safe to consume. It is also important to be aware that the FDA do not monitor the quality and purity of belladonna supplements.

There are some side effects to consider before using belladonna. These side effects include:

• dry mouth
• red, dry skin
• inability to sweat
• muscle spasms
• blurred vision
• enlarged pupils
• hallucinations
• inability to urinate
• convulsions
• seizures
• coma

Women who are pregnant or breastfeeding may be at additional risk, as some of belladonna’s side effects may appear in the unborn child, and it might dry up milk production.

In addition to the side effects, belladonna may make some conditions worse. These include disorders that some manufacturers claim belladonna helps.

Conditions that belladonna can make worse include:

• acid reflux
• fever
• rapid heartbeat
• gastrointestinal (GI) tract infections
• high blood pressure
• constipation
• urination problems

Belladonna has negative interactions with certain medications as well, such as those for allergies and depression. Side effects of the interaction include a rapid heartbeat and rashes.

Belladonna can be a safe herbal supplement or part of medication but only when used properly under a doctor’s care and supervision. There are a number of side effects that should be considered before using belladonna as a supplement.

Additional research needs to be conducted to test the effectiveness of belladonna alongside the risks. Individuals should carefully consider their options before trying belladonna as a replacement or supplemental treatment.

Belladonna and Opium: Pediatric Medication

Pediatric Medicine

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Provided by Lexicomp ^® , this document contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Warning

• This drug is a strong pain reliever that may put your child at risk for addiction, abuse, or misuse of this drug. Misuse or abuse of this drug can lead to overdose and death. Check with your child’s doctor.
• Your child will be closely monitored to avoid misuse, abuse, or dependence on this drug.
• This drug can cause very serious and sometimes deadly breathing problems. If your child has slow, shallow, or difficult breathing, contact your doctor immediately.
• The risk of very serious and sometimes deadly breathing problems may be increased when your child starts this drug or if the dose is increased. Check with your child’s doctor.
• Even one dose of this drug, taken by another person or by mistake, can be deadly, especially in children. If this drug has been taken by another person or by mistake, get medical help right away.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• This drug contains an opioid. Serious side effects have occurred when using opioids with benzodiazepines, alcohol, marijuana, or other forms of cannabis, as well as prescription or over-the-counter drugs that can cause drowsiness or slow action. These effects include slow or labored breathing and death. Benzodiazepines include drugs such as alprazolam, diazepam, and lorazepam. Benzodiazepines can be used to treat many health conditions such as anxiety, sleep disorders, or seizures. If you have any questions, please consult your doctor.
• Many drugs interact with this drug and may increase the risk of side effects such as life-threatening breathing problems. Check with your doctor and pharmacist to make sure it is safe to use this drug with all your other drugs.
• Make sure your child does not consume alcohol or products containing alcohol. Dangerous, sometimes deadly, effects may develop.
• Seek immediate medical attention if your child does not respond, does not respond, or does not react in the usual way, feels very drowsy or dizzy, passes out, or if he sleeps and does not wake up.

If your daughter is pregnant:

• Long-term use of this drug during pregnancy may cause withdrawal symptoms in the newborn. This can be life threatening. Consult your doctor.

What is this drug used for?

• It is used to relieve pain that occurs with certain muscle spasms in the urinary tract.

What should I tell the doctor BEFORE my child takes this drug?

• If your child has an allergy to this drug, any of its ingredients, other drugs, foods, or substances. Tell the doctor about the allergy and how it manifested itself in the child.
• If your child has any of the following health conditions: severe reactions to opioid drugs, preterm labor, glaucoma, kidney or liver disease, seizures.
• If your child has any of these health conditions: Lung or breathing problems such as asthma, shortness of breath, or sleep apnea; high levels of carbon dioxide in the blood, gastrointestinal obstruction or narrowing.
• If your child currently has alcohol withdrawal.
• If your child has recently consumed large amounts of alcohol.
• If your child has taken medications for depression or certain other illnesses in the last 14 days. These include isocarboxazid, phenelzine, and tranylcypromine. An episode of very high blood pressure may occur.
• If your child is taking any of the following drugs: buprenorphine, butorphanol, linezolid, methylene blue, nalbuphine, or pentazocine.
• If the patient is a child under 12 years of age. Do not give this drug to children under 12 years of age.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Talk to your doctor or pharmacist about all medicines your child is taking (prescription and over-the-counter, natural, and vitamins) and any health problems. You need to make sure that this drug is safe to use for your child’s illnesses and in combination with other drugs he or she is already taking. Do not start, stop taking, or change the dosage of any drug your child is taking without the doctor’s approval.

What do I need to know or do while my child is taking this drug?

• Tell all health care providers who care for your child that your child is taking this drug. These are your child’s doctors, nurses, pharmacists and dentists.
• Have your child avoid tasks or activities that require attention until you see how this drug works for your child. This includes cycling, playing sports, or using items such as scissors, lawn mowers, electric scooters, toy cars, or motorized vehicles.
• To reduce the risk of dizziness or fainting, have your child get up slowly from a sitting or lying position. Make sure your child goes up and down the stairs carefully.
• Do not exceed the dose prescribed by your doctor. Do not use the drug more often or for longer than recommended. Violation of the instructions for taking the drug may increase the risk of serious side effects.
• If your child uses this drug for a long time or at high doses, it may not work as well and a higher dose may be needed to get the desired effect. The patient develops a so-called tolerance to the drug. Call your doctor if this drug stops working as you want. Do not give your child higher doses of this drug than the doctor has prescribed.
• Long-term or regular use of opioid medications like this can lead to addiction. Reducing the dose or stopping this drug suddenly can cause a serious risk of withdrawal reactions or other serious problems. Check with your child’s doctor before reducing the dose or stopping this drug. You must follow the doctor’s instructions. Tell your child’s doctor if your child has severe pain, mood changes, suicidal thoughts, or any other side effects.
• This drug may increase the risk of seizures in some people, including people who have had seizures in the past. Check with your doctor to find out if your child is at increased risk of seizures while taking this drug.
• Bright light can irritate the child. Make sure your child wears sunglasses.
• Do not give this drug with other strong pain medicines or if you are using a pain patch without talking to your child’s doctor first.

If your daughter is pregnant or breastfeeding:

• If your daughter takes this medicine during pregnancy, it could harm the fetus. If your daughter is pregnant or becomes pregnant while taking this drug, call your doctor right away.
• If your daughter is breastfeeding, tell your daughter’s doctor. This drug passes into breast milk and may harm your daughter’s baby.

What side effects should I report to my child’s doctor right away?

WARNING/CAUTION: Although rare, some people may have very serious and sometimes deadly side effects of this drug. Call your child’s doctor right away or get medical help if your child has any of the following signs or symptoms that could be associated with a very bad side effect:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Labored, slow or shallow breathing.
• Breathing disorders during sleep (sleep apnea syndrome).
• Noisy breathing.
• Severe dizziness or fainting.
• Severe constipation or abdominal pain. These may be signs of a severe bowel disorder.
• Seizures.
• Pain or pressure in the chest or a fast heartbeat.
• Confusion of consciousness.
• Obstruction of the urinary tract.
• Blurred vision.
• If bright light irritates your child’s eyes.
• Difficulties with walking.
• If your child takes this drug with other drugs, a bad and sometimes deadly condition called serotonin syndrome can develop. Call your child’s healthcare provider right away if your child has agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythm, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting, severe headache.
• Taking opioid pain medications like this can cause a rare but severe adrenal disorder. If your child feels very tired or weak, passes out, or has severe dizziness, severe nausea, vomiting, or loss of appetite, call their healthcare provider right away.
• Long-term use of an opioid medicine can lead to a decrease in the level of sex hormones. If your child has a decreased interest in sex, fertility problems, no menstruation, or problems with ejaculation, see your doctor.

What are some other side effects of this drug?

Any drug can cause side effects. However, for many people, side effects are either minor or non-existent. Contact your child’s doctor or seek medical attention if any of these or other side effects bother your child or if they persist:

• Feeling dizzy, drowsy, tired or weak.
• Dry mouth.
• Nausea or vomiting.
• Constipation.
• Headache.
• Pain in the intestines.

This list of possible side effects is not exhaustive. If you have any questions about side effects, ask your child’s doctor. Talk to your child’s doctor about side effects.

You can report side effects to the National Health Board.

What is the best way to give this drug?

Give this drug to your child as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

• Apply the suppository to the rectum.
• Before use, remove the foil wrapper and moisten the candle with cold water. Ask the child to lie on their side. Using your finger, insert the suppository into the rectum at the optimal distance.

What if my child misses a dose of medication?

• If your child takes the drug regularly, give the missed dose as soon as you remember it.
• If it is time for your child to take the next dose, do not take the missed dose and then go back to your child’s normal schedule.
• Do not give a double dose at the same time or additional doses.
• In most cases, this drug is used as needed. Do not give your child the drug more often than prescribed by the doctor.

How do I store and/or discard this drug?

• Store at room temperature. Do not place in refrigerator or freezer.
• Store in a dry place. Do not store in the bathroom.
• Keep this medicine in a protected place out of sight and reach of children and out of the reach of other people. A box or room that is locked with a key can act as a secure storage place for the drug. Keep all medicines out of the reach of pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General information about medicines

• If your child’s symptoms or health problems do not improve, or worsen, contact your child’s doctor.
• Do not share your child’s medicine with others and do not give anyone else’s medicine to your child.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your child’s doctor, nurse, pharmacist, or other health care professional.
• An overdose of this drug can be treated with the drug naloxone. Your child’s doctor may prescribe naloxone to keep with you while your child takes this drug. Talk to your doctor or pharmacist if you have any questions about the use of this drug in your child. If you think you have overdosed, call a poison control center or get medical help right away, even after using naloxone. Be prepared to tell or show what drug was taken, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2022-07-08

Copyright

© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

Allergosan granules 20 g

Producer

Homeopharm

Product form

granules 20 g

Composition

Apis C 3, Belladonna C3, Fragaria C 3, Urtica C3.

Indications

skin itching of various etiologies, angioedema, cold allergy, food allergy, dermatitis, eczema, urticaria, bronchial asthma (as part of complex therapy), vasomotor rhinitis, allergic rhinitis, hay fever, allergic manifestations of flowering, allergic dermatitis

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How to use

The combination of components allows the use of Allergosan as a basic or main drug in acute conditions accompanied by an allergic component. Successfully implements humoral and tissue components of acute allergic reactions in: hay fevers, allergic rhinitis (hay fever) – spring and summer allergies to flowering. At the same time, treatment begins at least 3 months before flowering (course treatment) 1 granule per day, going into an exacerbation period up to 3-5 granules 2-3 times a day, with breaks of 1-2 days a week.

If there are acute reactions (swelling, mucosal hyperemia, rash) to a sudden irritant (dust, pungent odors and other allergens), you can take 3-4 times 1-3 granules until the allergic reaction stops (single doses) every 10-15 minutes until symptoms change, then less often – after 1-2 hours or after 3-4 hours until improvement.

In chronic processes – for a long time 3 granules 20-30 minutes before meals.

For rashes on the skin or mucous membranes, it is recommended to combine with local application of Allergin ointment.

Cannot be combined on the same day with Faringosan and Artrosan.

For allergic rashes or asthmatic conditions, an additional monocomponent homeopathic treatment may be required.

May be combined with other medical treatment (allopathic) during an exacerbation.

Locally, Allergin or Graphite ointments can be applied.

The drug is even more effective when combined with monocomponent drugs Astacus C3, Medusa C3, Hotarus C3.

Since a frequent cause of the development of allergic conditions are disorders in the work of the gastrointestinal tract, Laxatin, Dysbacteriosin, Fungisan, Helmintosan, Ulkusan in combination with Pancreasan, Hepatocholin – according to indications can be prescribed. (See also Dermadipin).

Description

ALLERGOSAN is a complex homeopathic preparation.

Therapeutic action: antiallergic, desensitizing, antiedematous, antispasmodic.

Indications for the use of the components of the complex:

1. APIS MELLIFICA – Apis C3, (Honey bee in breeding 10 – 6).

– Anti-inflammatory, decongestant, desensitizing, antiallergic.

– Action on the skin and mucous membranes, lymph.

– All diseases accompanied by edema: edema with stabbing pains, burning, sensitive to touch in the absence of thirst, tonsillitis, tonsillitis, urticaria; diseases accompanied by accumulation of fluid in tissues or cavities: ovarian cysts, dropsy tumors of renal origin, serous discharge during pleurisy, conjunctivitis, panaritium; symptoms of irritation, inflammation of the brain and meninges; kidney disease, nephritis after hemorrhagic fever and scarlet fever, erysipelas (especially on the face).

2. ANTIMONIUM CRUDUM – Antimon. crud. C12 (Black sulphurous antimony in intelligence 10-24)

– Cold and food allergy;

– Food allergy with indigestion and gastritis with feeling of fullness, heaviness in the stomach; with aversion to food, white coating of the tongue, burning in the rectum.

– Skin lesions: weeping eczema, fissures, keratinization, calluses, brittle nails.

– Roughness of the skin from cold, with cracks.

3. BELLADONNA – Belladonna C3, (Beauty. Belladonna at a dilution of 10 -6)

– Anti-inflammatory, anti-spastic, anti-allergic agent that regulates vasomotor disorders.

– Action on the nervous lymphatic system, mucous membranes, skin, tissue.

4. FRAGARIA – Fragaria C3, (Wild strawberry in breeding 10 – 6).

– Food, cold allergy, urticaria.

– Promotes the elimination of homotoxins in chronic diseases accompanied by auto-immune processes (gout, diseases of the liver, spleen, kidneys, atherosclerosis).