When should you take Latuda for maximum effectiveness. How does Latuda dosage vary for adults and children. What factors affect the optimal time to take Latuda. How can you ensure proper absorption of Latuda.

Understanding Latuda: An Atypical Antipsychotic Medication

Latuda (lurasidone) is a prescription medication approved by the Food and Drug Administration (FDA) for treating major depressive episodes associated with bipolar I disorder and schizophrenia. This atypical antipsychotic is available as an oral tablet and comes in various strengths to accommodate different patient needs.

Is Latuda suitable for children? Yes, Latuda is approved for use in children as young as 10 years old for bipolar depression and 13 years old for schizophrenia. This makes it a versatile option for both adult and pediatric patients struggling with these mental health conditions.

Latuda Dosage Forms and Strengths: Tailoring Treatment to Individual Needs

Latuda is exclusively available as an oral tablet, making it convenient for daily administration. The medication comes in five different strengths:

• 20 milligrams (mg)
• 40 mg
• 60 mg
• 80 mg
• 120 mg

This range of strengths allows healthcare providers to fine-tune dosages for optimal therapeutic effect while minimizing side effects. How does a doctor determine the right dosage? Typically, they start with the lowest effective dose and adjust gradually based on the patient’s response and tolerance.

Optimal Timing: When Is the Best Time to Take Latuda?

Timing is crucial when it comes to taking Latuda. For maximum effectiveness, it should be taken once daily, preferably at the same time each day. This consistency helps maintain steady levels of the medication in your system, ensuring continuous therapeutic effects.

Should Latuda be taken with food? Absolutely. It’s essential to take Latuda with a meal or substantial snack of at least 350 calories. This requirement isn’t just a suggestion—it’s critical for proper absorption of the medication. Taking Latuda with food helps it stay in your system long enough for your body to absorb the full dose effectively.

Tips for Incorporating Latuda into Your Daily Routine

1. Set a daily alarm as a reminder
2. Take Latuda with your largest meal of the day
3. Keep a food diary to ensure you’re consuming enough calories with your dose
4. Use a pill organizer to track your medication

Dosage Guidelines for Adults: Treating Bipolar Depression and Schizophrenia

The dosage of Latuda can vary depending on the condition being treated and individual patient factors. For bipolar depression in adults, the typical starting dose is 20 mg once daily, with a maximum daily dose of 120 mg. In cases of schizophrenia, adults usually start with 40 mg once daily, with a maximum dose of 160 mg per day.

Can Latuda be combined with other medications for bipolar depression? In some cases, yes. For adults with bipolar depression, Latuda may be used in conjunction with lithium or valproate, but this should only be done under close medical supervision.

Pediatric Dosing: Latuda for Children and Adolescents

Latuda’s approval for use in younger patients has been a significant development in pediatric psychiatry. For children aged 10 years and older with bipolar depression, the starting dose is typically 20 mg once daily, with a maximum daily dose of 80 mg. Adolescents aged 13 and older being treated for schizophrenia usually start with 40 mg once daily, also with a maximum of 80 mg per day.

Are there special considerations for administering Latuda to children? Indeed, careful monitoring is essential when prescribing Latuda to younger patients. Parents and caregivers should work closely with healthcare providers to ensure proper dosing and watch for any potential side effects.

Factors Influencing Latuda Dosage: Personalized Treatment Approaches

Several factors can affect the appropriate dosage of Latuda for an individual patient. These may include:

• Age
• Liver and kidney function
• Severity of symptoms
• Response to treatment
• Other medications being taken

Does liver or kidney function impact Latuda dosing? Yes, patients with impaired liver or kidney function may require dosage adjustments. In these cases, doctors may start with a lower dose and increase it more cautiously.

Long-Term Use of Latuda: Managing Chronic Mental Health Conditions

Latuda is designed for long-term use in managing bipolar depression and schizophrenia. Many patients find that continuous treatment helps maintain symptom control and prevents relapse. However, the decision to continue Latuda long-term should be made in consultation with a healthcare provider, taking into account the individual’s response to the medication and any potential side effects.

How often should patients on long-term Latuda therapy be evaluated? Regular follow-ups are crucial. Most healthcare providers recommend check-ins every few months to assess the medication’s ongoing effectiveness and to monitor for any developing side effects or necessary dosage adjustments.

Drug Interactions and Latuda: Ensuring Safe and Effective Treatment

Certain medications can interact with Latuda, potentially affecting its efficacy or increasing the risk of side effects. Of particular concern are drugs that affect the CYP3A4 enzyme in the body, which plays a role in metabolizing Latuda.

What types of medications might interact with Latuda? Common interacting drugs include certain antifungals, antibiotics, and other psychiatric medications. It’s crucial for patients to provide their healthcare providers with a complete list of all medications, supplements, and herbal products they’re taking to avoid potential interactions.

Steps to Minimize Drug Interaction Risks

1. Inform all healthcare providers about Latuda use
2. Avoid starting new medications without consulting your doctor
3. Be cautious with over-the-counter medications and supplements
4. Follow dosing instructions carefully
5. Report any unusual symptoms or side effects promptly

By being proactive and communicative about potential drug interactions, patients can help ensure the safe and effective use of Latuda in their treatment regimen.

Monitoring and Adjusting Latuda Treatment: A Dynamic Process

The journey with Latuda is not static; it often requires ongoing assessment and adjustment. Healthcare providers typically monitor patients closely, especially during the initial weeks of treatment, to evaluate the medication’s effectiveness and any potential side effects.

How can patients actively participate in their Latuda treatment? Keeping a symptom diary can be incredibly helpful. This allows patients to track their mood, energy levels, sleep patterns, and any side effects, providing valuable information for their healthcare team to make informed decisions about treatment.

Key Aspects of Latuda Treatment Monitoring

• Regular psychiatric evaluations
• Blood tests to check metabolic parameters
• Assessment of weight and body mass index
• Monitoring for movement disorders
• Evaluation of cardiovascular health

By maintaining open communication with healthcare providers and actively participating in treatment monitoring, patients can help ensure that their Latuda regimen remains optimized for their individual needs.

In conclusion, while Latuda can be an effective treatment for bipolar depression and schizophrenia, its success largely depends on proper administration and monitoring. Understanding the best time to take Latuda, adhering to dosage guidelines, and being aware of potential interactions are all crucial aspects of maximizing the medication’s benefits while minimizing risks. As with any psychiatric medication, Latuda should be used under the close supervision of a qualified healthcare provider, with ongoing evaluation to ensure it continues to meet the patient’s evolving needs.

Strengths, form, when to take, and more

Latuda (lurasidone) is a prescription brand-name medication. The Food and Drug Administration (FDA) has approved it to treat:

• Major depressive episodes linked to bipolar I disorder. The drug is for use in adults as well as children ages 10 years and older.
• Schizophrenia. The drug is for use in adults as well as children ages 13 years and older.

Latuda comes as an oral tablet. It contains the active drug lurasidone and belongs to a class of drugs called atypical antipsychotics. (A class of drugs is a group of medications that work in a similar way.) Latuda is currently available only as a brand-name medication. It doesn’t come in generic form.

For information on the dosage of Latuda, including its form, strengths, and how to take the drug, keep reading. For a comprehensive look at Latuda, see this article.

This article describes typical dosages for Latuda provided by the drug’s manufacturer. When taking Latuda, always follow the dosage prescribed by your doctor.

Latuda is approved to treat major depressive episodes linked to bipolar I disorder in adults and certain children. The drug also treats schizophrenia in adults and certain children.

Latuda form

Latuda comes as an oral tablet.

Latuda strengths

Latuda tablets are available in five strengths: 20 milligrams (mg), 40 mg, 60 mg, 80 mg, and 120 mg.

Typical dosage guide

The typical dose range for Latuda is 20 mg to 120 mg. There is no “average dose” of the drug. Typically, your doctor will start you on the lowest dose of Latuda for your condition. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

Your doctor will monitor how well Latuda is helping ease symptoms. You may have a dose increase if they think it will help with the condition Latuda is treating.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for bipolar depression

Latuda treats major depressive episodes linked to bipolar I disorder in adults. This stage in bipolar I disorder may also be called bipolar depression. Latuda may also be used in adults with the drugs lithium or valproate for this condition.

For these purposes, the typical starting dosage of Latuda for adults is 20 mg, once per day. The maximum Latuda daily dose is 120 mg.

Dosage for schizophrenia

In adults, the typical starting dosage for Latuda for schizophrenia is 40 mg, once per day. The maximum Latuda daily dose is 160 mg.

Latuda dosages vary depending on several factors. (See the “Factors that can affect your dosage” section below.) Your doctor will determine the dosage that’s best for you.

When to take Latuda

You’ll likely take Latuda once daily. Try to take the drug at about the same time each day. By doing this, the level of the drug in your body can stay constant and work effectively.

You should take Latuda with a meal or large snack of at least 350 calories. This helps Latuda stay in your system long enough for your body to absorb the full dose.

Long-term use

Latuda is meant to be used as a long-term treatment. If you and your doctor determine that Latuda is safe and effective for you, you’ll likely take it long term.

Children’s dosage

Here’s some information about Latuda dosages in children.

Children’s dosage for bipolar depression

Latuda treats major depressive episodes linked to bipolar I disorder. This stage in bipolar I disorder may also be called bipolar depression. The drug is approved for use in children ages 10 years and older.

For this purpose, the typical starting dosage is 20 mg, once per day. The maximum Latuda daily dose for this age group is 80 mg.

Latuda dosages vary depending on several factors. (See the “Factors that can affect your dosage” section below.) Your child’s doctor will determine the dosage that’s best for your child.

Children’s dosage for schizophrenia

Latuda is approved to treat schizophrenia in children ages 13 years and older. For this purpose, the typical starting dosage is 40 mg, once per day. The maximum daily Latuda dose for this age group is 80 mg.

Latuda dosages vary, depending on several factors. (See the “Factors that can affect your dosage” section below.) Your child’s doctor will determine the dosage that’s best for your child.

Dosage adjustments

Certain conditions may affect how your body responds to Latuda. Your doctor may reduce your dosage if you have problems with your liver or kidneys.

Also, some drugs may cause you to have too much or too little Latuda in your body. Certain medications that affect an enzyme in the body called CYP3A4 can interact with Latuda. To learn more about the drugs that can interact with Latuda, see this article.

It’s important to talk with your doctor about all medications that you take so they can increase or decrease your dosage as needed.

The Latuda dosage your doctor prescribes will depend on several factors. These include:

• the type and severity of the condition you’re using Latuda to treat
• your age

Other medical conditions you have can also affect your Latuda dosage. For more information, see “Dosage adjustments” in the “Dosage” section above.

If you miss a dose of Latuda, take it as soon as you remember. If it’s almost time for your next dose, don’t “double up” on your dose. Just take the next dose as you normally would. If you have questions about when to take a missed dose, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or timer on your phone or downloading a reminder app. A kitchen timer can work, too.

Here are some frequently asked questions about Latuda and their answers.

What’s the Latuda dosage for bipolar 2 disorder?

Latuda isn’t approved to treat bipolar 2 disorder (also called bipolar II disorder). But some doctors may prescribe Latuda off-label for bipolar 2 disorder. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.

If you are interested in taking Latuda for bipolar 2 disorder, talk with your doctor.

Can I chew, split, or crush Latuda?

No. You shouldn’t chew, split, or crush Latuda tablets. Be sure to swallow them whole.

If you have trouble swallowing pills, talk with your doctor or pharmacist. They may be able to suggest ways to make medication easier to take.

Latuda comes as an oral tablet that you swallow. You should take the drug with a meal or large snack of at least 350 calories. This helps Latuda stay in your system long enough for your body to absorb the full dose.

You’ll likely take Latuda once daily. Try to take the medication at about the same time each day. By doing this, the level of the drug in your body can stay constant and work effectively.

In clinical studies, people taking Latuda did not misuse the drug. But because of the way the medication acts on the brain, it could lead people to misuse Latuda.

If you have misused drugs before, talk with your doctor. They can advise you on how to use Latuda safely.

It’s important that you don’t use more Latuda than your doctor prescribes. For some medications, taking more than the recommended amount may lead to side effects or overdose.

If you take more than the recommended amount of Latuda

Call your doctor right away if you believe you’ve taken too much of Latuda. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

The dosages in this article are typical dosages provided by the drug manufacturer. If your doctor recommends Latuda for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes for you.

As with any drug, never change your dosage of Latuda without your doctor’s approval. If you have questions about the dosage of Latuda that’s right for you, talk with your doctor.

Besides learning about dosage, you may want other information about Latuda. These additional articles might be helpful to you:

• More about Latuda. For information about other aspects of Latuda, refer to this article.
• Details on bipolar disorder and schizophrenia. For details on bipolar disorder, see our list of bipolar disorder articles. To learn more about schizophrenia, see our list of schizophrenia articles.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Form, Strengths, How to Use, and More

If you’re looking at treatment options for schizophrenia or for depressive episodes related to bipolar I disorder, your doctor might suggest Latuda (lurasidone).

Latuda is a prescription medication that comes as a tablet. Latuda can be taken on its own or with other medications, depending on the condition it’s treating.

Latuda is approved to treat the following conditions:

• schizophrenia in adults and children ages 13 years and older
• depressive episodes related to bipolar I disorder in adults and children ages 10 years and older, taken on its own
• depressive episodes related to bipolar I disorder in adults as an adjunct (add-on) medication with lithium or valproate

This article describes the dosages of Latuda, including its form, strengths, and how to take the drug. To learn more about Latuda, see this in-depth article.

Note: This article covers Latuda’s typical dosages, which are provided by the drug’s manufacturer. But when using Latuda, always take the dosage that your doctor prescribes.

The recommended dose of Latuda your doctor will prescribe may depend on a few factors:

• the type and severity of the condition you’re using Latuda to treat
• your age
• other medical conditions you may have
• other medications you may be taking

What is Latuda’s form?

Latuda comes as a tablet that you take by mouth, usually with food.

What strengths does Latuda come in?

Latuda comes in five strengths:

• 20 milligrams (mg)
• 40 mg
• 60 mg
• 80 mg
• 120 mg

What are the typical dosages of Latuda?

Typically, your doctor will start you on a low dosage. Then they’ll adjust your dosage over time to reach the right amount for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Below is a dosage guide for starting dosages and recommended dosage ranges for all of the conditions Latuda treats. Doses are given in mg.

Condition	Starting dosage	Recommended dosage
schizophrenia in adults	40 mg once daily	40–160 mg once daily
schizophrenia in children (ages 13 years and older)	40 mg once daily	40–80 mg once daily
bipolar depression in adults*	20 mg once daily	20–120 mg once daily
bipolar depression in children (ages 10 years and older)	20 mg once daily	20–80 mg once daily

* The dosage range is the same when Latuda is taken on its own or with lithium or valproate.

Dosage for schizophrenia

Latuda is approved to treat schizophrenia in adults and children ages 13 years and older.

The recommended starting dosage for schizophrenia is 40 mg once daily. The recommended dose range is between 40 mg to 160 mg for adults. (For children’s dosage, see “What’s the dosage of Latuda for children?” below.)

Your doctor may increase your dose if the starting dose isn’t helping with your condition. Note that there is no average dose for schizophrenia, as the drug affects individuals differently. You should take the dose that’s recommended by your doctor.

Dosage for depressive episodes related to bipolar I disorder

Latuda is approved to treat major depressive episodes related to bipolar I disorder in adults and children ages 10 years and older. It’s not approved for use in people with bipolar II disorder.

For bipolar depression in adults, Latuda can be taken on its own or as an adjunct (add-on) medication with valproate or lithium.

The recommended starting dosage for bipolar depression is 20 mg once daily. The recommended dose range is 20 mg to 120 mg for adults. (For children’s dosage, see “What’s the dosage of Latuda for children?” below.)

Your doctor may increase your dose if the starting dose isn’t helping with your condition. Note that there is no average dose for bipolar depression, as the drug affects individuals differently. You should take the dose that’s recommended by your doctor.

When should I take Latuda?

You should take Latuda once each day. You can take the medication any time throughout the day. But it’s usually best to take it around the same time each day.

You should take Latuda with food that’s at least 350 calories. So you may want to take Latuda after a meal. This helps your body absorb the drug better.

To make sure you don’t miss a dose, you may want to use a medication reminder.

Is Latuda used long term?

Yes, Latuda is typically used as a long-term treatment. If you and your doctor determine that Latuda is safe and effective for you, it’s likely that you’ll use it long term.

What’s the dosage of Latuda for children?

Latuda is approved to treat schizophrenia in children ages 13 years and older. The starting dose for schizophrenia is 40 mg. In children, the dose range for schizophrenia is between 40 mg and 80 mg. Your child’s doctor may recommend a Latuda dose increase if the starting dose isn’t effective for your child.

To treat depressive episodes related to bipolar I disorder, Latuda is approved for children ages 10 years and older. The starting dose for bipolar depression is 20 mg. In children, the dose range for bipolar depression is between 20 mg and 80 mg. Your child’s doctor may recommend a Latuda dose increase if the starting dose isn’t effective for your child.

Dosage adjustments

If you have certain medical conditions or are taking certain drugs, your doctor may suggest you take a dose of Latuda that’s different from what’s typically recommended. This is to help make sure the drug is working effectively and to lower the risk of side effects.

Adjustments for medical conditions

If you have liver or kidney problems, the recommended starting dose for any condition Latuda treats is 20 mg once daily. And the maximum recommended dose is 80 mg. If you have severe liver problems, the maximum recommended dose is 40 mg.

Adjustments for medications

If you take certain medications that interact with Latuda, you’ll need an adjustment to your dose of Latuda.

Some medications affect an enzyme called CYP3A4, which is responsible for breaking down Latuda. Drugs that block CYP3A4 (CYP3A4 inhibitors) increase the level of Latuda in your body. Some drugs can increase CYP3A4 in your body (CYP3A4 inducers), which decreases the level of Latuda.

Tell your doctor about any medications you’re taking. This will help them to determine the right dose of Latuda for you.

To learn more about the drugs that could interact with Latuda, see this in-depth article on the drug.

If you miss a dose of Latuda, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take your next dose at the normal time. Don’t take two doses to make up for the missed dose. This increases your risk for side effects.

If you need help remembering to take your dose of Latuda on time, try using a medication reminder. This can include setting an alarm, downloading a reminder app, or setting a timer on your phone. A kitchen timer can work, too.

The dosage of Latuda you’re prescribed may depend on several factors. These include:

• the type and severity of the condition you’re using Latuda to treat
• your age
• other conditions you may have and other medications you may be taking (see “Dosage adjustments” under “What is Latuda’s dosage?”)

You should take Latuda with food. Specifically, the food you take with the drug should contain at least 350 calories. This helps your body absorb the drug better.

Swallow Latuda tablets whole. Don’t crush, break, or chew them

Avoid grapefruit and grapefruit juice, as they may interact with Latuda and raise the level of the drug in your body.

Latuda hasn’t been studied for misuse, and it isn’t a controlled substance. (The United States government regulates use of controlled substances.)

In studies of Latuda, there were no reports of behaviors that indicate dependence on this drug. But if you have a history of drug misuse, talk with your doctor before starting treatment with Latuda.

Don’t use more Latuda than your doctor prescribes. Using more than this can lead to serious side effects.

What to do in case you take too much Latuda

Call your doctor right away if you think you’ve taken too much Latuda. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use its online resource. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

The sections above describe the typical dosages provided by the drug manufacturer. If your doctor recommends Latuda for you, they will prescribe the dosage that’s right for you.

Remember, you shouldn’t change your dosage of Latuda without your doctor’s approval. Only take Latuda exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

• How will my Latuda dose change if I’m taking other medications?
• Are there any foods or supplements I should avoid while taking Latuda?
• Does my dosage of Latuda need to change if I have certain health conditions?

Q:

How will I know if I need a change in my dose of Latuda?

Anonymous patient

A:

Your dose of Latuda may change over the course of your treatment.

Typically, your doctor will start you on a low dosage of Latuda. If your symptoms increase or don’t lessen for the condition you’re being treated for, your doctor will likely increase the dosage of Latuda.

If you experience any side effects while taking Latuda, your doctor will likely decrease your dosage.

It’s important that you tell your doctor if you experience worsening of symptoms for the condition that is being treated or if you develop side effects while taking Latuda.

Melissa Badowski, PharmD, MPH, FCCPAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Latuda vs Abilify: Differences, Similarities & What’s Best for You – Drug Vs. Friend

Home >> Drug Vs. Friend >> Latuda vs Abilify: Differences, Similarities & What’s Best for You

Drug Vs. Friend

Drug Overview and Key Differences | Conditions of treatment | Efficiency | Insurance coverage and cost comparison | Side effects | Drug Interactions | Warnings | Frequently Asked Questions

Latuda (lurasidone) and Abilify (aripiprazole) are brand-name prescription drugs used to treat schizophrenia. Schizophrenia is a mental disorder characterized by symptoms such as delusions, hallucinations, and disorganized speech or behavior. In addition to schizophrenia, Latuda and Abilify can also treat other mental disorders.

Both Latuda and Abilify are classified as atypical antipsychotics or second-generation antipsychotics. They work in a similar way to reduce the symptoms of schizophrenia. Although their exact mode of action is unknown, these antipsychotic drugs interact with dopamine and serotonin receptors in the brain.

What are the main differences between Latuda and Abilify?

The main difference between Latuda and Abilify is that they contain different active ingredients. Latuda contains lurasidone and Abilify contains aripiprazole.

Latuda was approved by the FDA in 2010 for the treatment of schizophrenia and bipolar depression. It is available as oral tablets in dosages of 20 mg, 40 mg, 60 mg, 80 mg, and 120 mg. Latuda reaches maximum levels in the body within one to three hours. Latudu is usually started at 20 or 40 mg per day, depending on the condition being treated and should be taken. with food for better absorption.

Abilify was approved by the FDA in 2002 for the treatment of schizophrenia and other mental illnesses such as bipolar disorder, autism and Tourette’s disorder. Abilify is available in 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, and 30 mg oral tablets. It is also available as an orally disintegrating tablet, oral solution, and injection. Abilify oral tablets peak in the body within three to five hours of ingestion and can be taken with or without food. 9Abilify 2

Drug class Antipsychotics Antipsychotics Brand / generic status Brand and generic versions available Brand and generic versions available What is the common name? Lurasidone Aripiprazole What form(s) does the drug come in? Oral tablet Oral tablet
Oral disintegrating tablet
Oral solution
Powder for suspension for intramuscular administration ration? Adult schizophrenia:
40 to 160 mg daily Adolescent schizophrenia (13 to 17 years):
40 to 80 mg daily Adult schizophrenia:
10 to 15 mg daily Adolescent schizophrenia (13 to 17 years of age) ):
2 to 10 mg per day How long does a typical treatment last? Varies: patients should be reevaluated periodically. Varies: patients should be reevaluated periodically. Who usually takes this medicine? Adults, adolescents and children 10 years of age and older (depending on the condition being treated) Adults, adolescents and children 6 years of age and older (depending on the condition being treated)

treated with Latuda and Abilify

Latuda is used to treat schizophrenia in adults and children 13 years of age and older. It is also approved for the treatment of depressive episodes associated with bipolar I disorder in adults and children 10 years of age and older.

Abilify is also used to treat schizophrenia in adults and children 13 years of age and older. However, unlike Latuda, it is approved for the treatment of mixed or manic episodes associated with bipolar I disorder in adults and children 10 years of age and older. Abilify can also treat Tourette’s disease or Tourette’s syndrome and irritability associated with autistic disorder. When given with additional antidepressant therapy, Abilify may treat major depressive disorder (MDD). Abilify injections are FDA approved for the treatment of arousal symptoms from schizophrenia and bipolar mania.

Condition	Latuda	Abilify
Schizophrenia	yes	yes
Bipolar disorder depressive disorder	No	yes
Autistic disorder	No	yes
Tourette’s disorder	No	yes

Latuda or Abilify more effective?

Latuda and Abilify are effective drugs for the treatment of schizophrenia, a serious mental illness. The best treatment will depend on factors such as the condition being treated, possible side effects, and cost.

One meta-analysis compared antipsychotics such as lurasidone, olanzapine, quetiapine, risperidone and paliperidone. The researchers found that lurasidone was comparable to other antipsychotics for the treatment of schizophrenia. However, lurasidone has been found to have less weight gain and a lower risk of other side effects compared to other atypical antipsychotics.

Another meta-analysis from the World Journal of Biological Psychiatry compared lurasidone with other antipsychotics for the treatment of bipolar depression. The analysis evaluated more than 10 different clinical trials involving more than 6,000 patients. Antipsychotics such as lurasidone, quetiapine, aripiprazole, olanzapine, and ziprasidone have been compared in terms of safety and efficacy. The study concluded that lurasidone may be more effective than aripiprazole and ziprasidone and may cause less weight gain and drowsiness than other antipsychotics.

Talk to your doctor about the best treatment for you.

Coverage and cost comparison of Latuda and Abilify

The FDA approved the generic version of Latuda. However, a generic version may or may not be available on the market. As a branded drug, Latuda can be expensive even with insurance. Medicare and insurance plans usually cover Latuda, although co-payments may vary by plan. When paying in cash, the Latuda is priced at $1,783.52. A SingleCare coupon can bring the cost down to about $1,200.

Abilify is available as generic and brand name products. Most Medicare programs and insurance plans are covered by Abilify. Compared to Latuda, Abilify may be a cheaper treatment option. However, when paying in cash, the price can still be high at around $1,059.99. Abilify’s SingleCare Discount Card can bring the cost down to $100.

	Latuda	Abilify
Usually covered?	yes	yes
Usually covered by Medicare Part D?	yes	yes
Quantity	30 tablets (40 mg)	30 tablets (5 mg)
Typical Medicare copay	$7-46	$3-$204
SingleCare Cost	$1236 + $	$65+

General Side effects of Latuda vs.

Abilify

The most common side effects of Latuda include drowsiness, restlessness or a desire to move (akathisia), nausea, and vomiting. Other side effects of Latuda may include muscle stiffness, tremors, and weight gain.

The most common side effects of Abilify include nausea, vomiting, sedation or drowsiness, dizziness, constipation, headache, blurred vision, akathisia and insomnia. Other side effects of Abilify include muscle stiffness and weight gain.

Both Latuda and Abilify may cause high blood sugar and cholesterol levels. Serious side effects of Latuda and Abilify may include low white blood cell counts, seizures, low blood pressure (orthostatic hypotension), and uncontrolled body movements (tardive dyskinesia).

See below for other side effects of Latuda and Abilify.

	Latuda	Abilify
Side effect	Applicable?	Frequency	Applicable?	Frequency
Drowsiness	yes	17%	yes	5% 9003 9
Akathisia	yes	13%	yes	13%
Nausea	yes	10%	yes	fifteen%
6 yes	eleven%
Indigestion	yes	6%	yes
Insomnia	yes	5%	yes	18%
Anxiety	yes	5%	yes	17%
Dizziness	yes	5%	yes	3%
Weight gain 9 0039	yes	3%	yes	3%
Back pain	yes	3%	no	–
blurred vision	3%
Dry mouth	yes	*	yes	5%
Constipation	no 39	eleven%
Headache	No	–	yes	10%
Muscle pain	No	–	yes	two%

*not reported
9 0003 Frequency not based on face-to-face trial data. This may not be a complete list of side effects that you may experience. Please contact your doctor or health care provider for more information.
Source: DailyMed ( Latuda ), DailyMed ( Abilify )

Latuda vs. Abilify drug interactions

Latuda and Abilify are primarily metabolized in the liver by CYP3A4. Their use may need to be avoided, adjusted or monitored in combination with drugs that act as CYP3A4 inhibitors or CYP3A4 inducers. Medicines that act as CYP3A4 inhibitors, such as ketoconazole and ritonavir, may cause an increase in latuda or abilifi levels and increase the risk of side effects. Drugs that act as CYP3A4 inducers, such as rifampicin and carbamazepine, may cause a decrease in Latuda or Abilify levels and reduce the effectiveness of antipsychotics. The combination of Abilify and CYP2D6 inhibitors, such as quinidine and fluoxetine, may result in increased levels of Abilify and side effects.

The use of Latuda and Abilify may need to be monitored or avoided when using antihypertensive drugs or benzodiazepines. Taking these antipsychotics with antihypertensives may increase the risk of low blood pressure. Benzodiazepines may exacerbate the sedative side effects of Latuda or Abilify.

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Drug	Drug class	Latuda	Abilify
Ketoconazole Fluconazole Clarithromycin Erythromycin Ritonavir Diltiazem Verapamil 9003 9	CYP3A4 inhibitors	yes	yes
Rifampicin Phenytoin Carbamazepine Efavirenz Etravirine St. John’s wort o	Inductors CYP3A4	yes	yes
Quinidine Fluoxetine Paroxetine	CYP2D6 inhibitors	No	yes
Amlodipine Lisinopril Losartan	Antihypertensives	yes
Alprazolam Diazepam Lorazepam	Benzodiazepines	yes	yes

Talk to your doctor about other possible drug interactions.

Latuda and Abilify warnings

Both Latuda and Abilify have black box warnings. Elderly people who take antipsychotic drugs have an increased risk of death and psychosis associated with dementia. Suicidal thoughts and behavior have also been reported in children and young adults using Latuda and Abilify. Younger patients may need to be monitored for worsening symptoms or changes in behavior while taking Latuda or Abilify.

Elderly patients with psychosis associated with dementia are at increased risk of cerebrovascular adverse events such as stroke and transient ischemic attacks. Taking Latuda or Abilify also carries a risk of neuroleptic malignant syndrome (NMS), which can cause symptoms such as high fever, muscle stiffness, confusion, and changes in heart rate. NMS is a serious condition that requires immediate medical attention.

Latuda and Abilify may cause metabolic changes such as high blood sugar, high cholesterol and weight gain. These medicines can also cause low white blood cell counts, seizures, and low blood pressure.

Consult your physician for other possible warnings and precautions before using Latuda or Abilify.

Frequently Asked Questions about Latuda vs. Abilify

What is Latuda?

Latuda is an atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. It is available as a tablet to take by mouth. Latuda is usually taken once a day with meals.

What is Abilify?

Abilify is an atypical antipsychotic drug used to treat schizophrenia and mixed or manic episodes associated with bipolar I disorder. Abilify is also approved for the treatment of major depressive disorder, autistic disorder, and Tourette’s disorder. It is available as an oral tablet, orally disintegrating tablet, oral solution, and injection. Abilify is usually taken once daily with or without food.

Are Latuda and Abilifi the same thing?

Both Latuda and Abilify are atypical antipsychotics or second-generation antipsychotics approved for the treatment of schizophrenia. However, they are available in different dosage forms and have indications other than schizophrenia. Latuda treats bipolar I depressive episodes and Abilify treats bipolar I manic episodes. Latuda also needs to be administered with food while Abilify can be administered with or without food.

Which is better: Latuda or Abilify?

Latuda and Abilify are effective drugs for schizophrenia and other mental illnesses. Latuda may be as effective as Abilify and other antipsychotics and may cause fewer side effects such as weight gain. There are other factors to consider when choosing Latuda or Abilify, such as cost. Talk to your doctor about the most suitable treatment option for you.

Can I use Latuda or Abilify while pregnant?

Studies on the use of Latuda and Abilify during pregnancy are limited. These antipsychotics can cause extrapyramidal symptoms or withdrawal symptoms in newborns in the third trimester. They should only be taken if the benefits outweigh the risks. Check with your doctor to see if you should use Latuda or Abilify during pregnancy.

Can I use Latuda or Abilify with alcohol?

Both alcohol and neuroleptics have a depressant effect on the central nervous system (CNS). Taking neuroleptics with alcohol may increase the risk of some side effects, such as drowsiness and dizziness. Limit alcohol consumption while taking Latuda or Abilify.

Latuda – mood stabilizer or antipsychotic?

Latuda is not a mood stabilizer. Instead, Latuda is an antipsychotic drug that may be prescribed along with a mood stabilizer such as Lithobid (lithium) or Depakene (valproic acid) to treat bipolar depression. Other examples of antipsychotics include Invega (paliperidone), Seroquel (quetiapine), Zyprexa (olanzapine), Geodon (ziprasidone), Rexulti (brexpiprazole), and vraylar (cariprazine).

Is there a generic for Latuda?

Latuda generic version has been approved by the FDA. However, the universal version of Latuda may not yet be available on the market. Generic manufacturers of Latuda include Accord Healthcare, Piramal Healthcare UK Limited and Sun Pharmaceutical Industries Ltd.

What happens if you don’t take Latuda with food?

Latuda may not work as well if taken without food. For optimal absorption, it is recommended that you take latuda with a meal containing at least 350 calories. The absorption of Latuda is doubled when taken with food.

How fast does Latuda work? – Medical Answers

Physical examination by Lee Ann Anderson, PharmD. Last updated: July 20, 2020

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Latuda (generic name: lurasidone) works in most patients within 6 weeks or less at the appropriate dose, although results may vary from patient to patient. Latuda is an atypical antipsychotic approved for the treatment of patients with schizophrenia or bipolar depression. Some patients may respond as early as 1 to 3 weeks; however, some patients may not respond at all or have side effects that interrupt treatment.

It is important that you take Latuda with food that contains at least 350 calories. Taking Latuda with food significantly increases the absorption of the drug into the body. Better suction can increase Latuda’s effectiveness.

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In randomized, placebo-controlled clinical trials conducted by the manufacturer in patients with schizophrenia or bipolar depression, significant primary endpoint results were observed after 6 weeks in various age groups.

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Latuda approved in the US for:

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• Schizophrenia in adults and adolescents (13 to 17 years of age)
• Bipolar depression (depressive episode associated with bipolar I disorder) in adults and children (from 10 up to 17 years) as monotherapy (used alone)
• Bipolar depression in adults when used in combination with lithium or valproate.

The efficacy of Latuda beyond 6 weeks has not been evaluated in controlled clinical trials. However, your doctor will periodically review your response to long-term use of Latuda if you continue treatment for more than 6 weeks.

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Schizophrenia

Latuda is an oral prescription drug given once a day. It may help control the symptoms of schizophrenia in people aged 13 and over.

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Latuda has been evaluated in many studies of adults living with schizophrenia and one study of adolescents aged 13–17 years. These studies looked at how well Latuda works, how safe it is, and how well people tolerate it.

• Latuda has been shown to be safe and effective in adult patients with schizophrenia. In studies, patients who received Latuda had fewer symptoms of schizophrenia than those who took the inactive pill (placebo) at the end of the 6-week study. Some patients have seen significant results in the first week.
• In adolescents with schizophrenia, one study found that Latuda was associated with improvement in schizophrenia symptoms compared to placebo (inactive) treatment at the end of 6 weeks. However, some patients experienced a significant reduction in symptoms as early as the first week.

Bipolar depression (depressive episode associated with bipolar I disorder)

Latuda has been studied in 6-week studies in adult patients with bipolar depression, using it as monotherapy (used alone) or in combination with other agents such as lithium or valproate.

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• A significant reduction in symptoms in adults was observed after 6 weeks. In some patients, the effect was observed as early as the second week in the study of monotherapy (Latuda was used alone). A 44% greater reduction in bipolar depression symptoms was observed at week 6 of Latuda compared to no active treatment.
• In combination studies with lithium or valproate, a significant reduction in symptoms was observed in some patients as early as 3 weeks. A 27% greater reduction in depressive symptoms was observed with Latuda at week 6 compared with lithium or valproate treatment in combination with inactive treatment.

In children and adolescents aged 10 to 17 years with bipolar depression, Latuda was associated with statistically significant and clinically significant improvements in bipolar depression symptoms compared with placebo in 6-week studies.

• Some patients showed a significant reduction in symptoms at week 2 of the study.
• At week 6, Latuda showed a 37% greater reduction in depressive symptoms compared to no active treatment.

To learn more about dosing Latuda in adults and children, visit: Latuda Dosing

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Bottom Line

• Latuda is an atypical antipsychotic approved in the US for the treatment of patients with schizophrenia or bipolar depression. Many clinical studies have found improvement in symptoms after 6 weeks of treatment, but in some patients, results were seen earlier.
• Patients with schizophrenia treated with Latuda may experience improvement in symptoms as early as the first week of treatment; however, studies assessed the full effect after 6 weeks.
• In patients with bipolar depression, significant results from treatment with Latuda may begin as early as the second or third week of treatment in some patients. These studies also assessed overall outcomes at 6 weeks.
• Some patients may not respond adequately to treatment with Latuda, or treatment may need to be discontinued due to side effects.

This is not all the information you need to know about Latuda in order to use it safely and effectively. Review the full prescribing information for Latuda here and discuss this information with your doctor or other health care provider.

Recommendations

• Latuda (lurasidone) [prescribing information]. Sunovion Pharmaceuticals Inc. December 2019 Accessed 20 July 2020 at https://www.latuda.com/LatudaPrescribingInformation.pdf
• Lebel A, Cucchiaro J, Silva S, et al. Lurasidone monotherapy in the treatment of bipolar depression I: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 2013;171(2):160-168.
• DelBello MP, Goldman R, Phillips D, et al. Efficacy and safety of lurasidone in children and adolescents with bipolar depression I: a double-blind, placebo-controlled study. J Am Acad Child and Adolescent Psychiatry. 2017;56(12):1015-1025.
• Lebel A, Cucchiaro J, Silva S, et al. Lurasidone as add-on therapy with lithium or valproate for the treatment of bipolar depression I: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 2013;171(2):169-177.
• Meltzer HY, Cucchiaro J, Silva R, et al. Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled trial. Am J Psychiatry.