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Can 8 year old take 500mg tylenol. Tylenol Dosing Guidelines: Proper Usage for Ages 8 and Up

How much Tylenol can an 8-year-old safely take. What are the recommended dosages for different Tylenol formulations. How to properly administer Tylenol to children and adults. What precautions should be taken when giving Tylenol to children.

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Understanding Tylenol Dosage for Children and Adults

Tylenol, also known by its generic name acetaminophen, is a common over-the-counter pain reliever and fever reducer. Proper dosing is crucial for safety and efficacy, especially when administering to children. This comprehensive guide will help you understand the correct Tylenol dosages for various age groups and formulations.

Can an 8-year-old take 500mg of Tylenol?

No, an 8-year-old should not take 500mg of Tylenol. This dosage is too high for a child of this age. The appropriate dose for an 8-year-old depends on their weight and the specific Tylenol formulation being used. Always consult the product packaging or a healthcare professional for precise dosing instructions.

Tylenol Dosing Guidelines for Children

When it comes to administering Tylenol to children, weight-based dosing is preferred over age-based dosing whenever possible. Here’s a general guide for Tylenol oral suspension:

  • 48-59 lbs (6-8 years): 10 mL of 160 mg/5 mL suspension
  • 60-71 lbs (9-10 years): 12.5 mL of 160 mg/5 mL suspension
  • 72-95 lbs (11 years): 15 mL of 160 mg/5 mL suspension

These doses can be given every 4 hours while symptoms last, not exceeding 5 doses in 24 hours unless directed by a doctor.

Adult Tylenol Dosage Recommendations

For adults and children 12 years and older, Tylenol offers various formulations with different dosing guidelines:

Regular Strength Tylenol (325 mg)

The recommended dosage for Regular Strength Tylenol is:

  • 2 tablets or capsules every 4-6 hours while symptoms last
  • Do not exceed 10 tablets or capsules in 24 hours
  • Total labeled daily dose: 3250 mg/day

Extra Strength Tylenol (500 mg)

For Extra Strength Tylenol formulations, including caplets, coated tablets, and dissolve packs, the guidelines are:

  • 2 units (caplets, tablets, or powders) every 6 hours while symptoms last
  • Do not exceed 6 units in 24 hours
  • Total labeled daily dose: 3000 mg/day

Professional Discretionary Dosing

In 2011, the makers of Tylenol lowered the labeled maximum daily dose for single-ingredient Extra Strength Tylenol products sold in the US. However, healthcare professionals may exercise their discretion in certain situations:

  • Previous maximum: 8 pills/day (4000 mg)
  • Current labeled maximum: 6 pills/day (3000 mg)
  • Healthcare professionals may recommend up to 4000 mg/day if pain or fever persists at the labeled daily dose

It’s important to note that the efficacy and safety of Tylenol at 4000 mg/day are well established.

Special Formulations and Their Dosing Guidelines

Tylenol offers several specialized formulations for specific needs. Here’s a brief overview of their dosing guidelines:

Tylenol 8HR Arthritis Pain Tablets

These extended-release tablets are designed to provide long-lasting relief for arthritis pain. The dosing instructions are:

  • 2 tablets every 8 hours
  • Do not exceed 6 tablets in 24 hours
  • Swallow tablets whole; do not crush, chew, or dissolve

Tylenol 8HR Muscle Aches & Pain Tablets

Similar to the arthritis pain formulation, these tablets offer extended relief for muscle aches and pain:

  • 2 tablets every 8 hours
  • Do not exceed 6 tablets in 24 hours
  • Swallow tablets whole; do not crush, chew, or dissolve

Tylenol PM Extra Strength Caplets

This nighttime formulation combines acetaminophen with a sleep aid. The dosing guidelines are:

  • 2 caplets at bedtime
  • Do not exceed 2 caplets in 24 hours
  • Use only at bedtime

Important Safety Considerations

When using Tylenol or any acetaminophen-containing product, keep these safety considerations in mind:

  1. Use only one medicine containing acetaminophen at a time to avoid accidental overdose.
  2. Always read and follow the label instructions carefully.
  3. For children, use weight-based dosing when possible.
  4. Never exceed the recommended daily dose unless directed by a healthcare professional.
  5. Be aware of other medications that may contain acetaminophen, such as cold and flu remedies.
  6. If symptoms persist or worsen, consult a healthcare provider.

When to Consult a Healthcare Professional

While Tylenol is generally safe when used as directed, there are situations where you should seek medical advice:

  • If you’re unsure about the correct dosage for a child
  • If pain or fever persists for more than 3 days
  • If you have liver disease or a history of alcohol abuse
  • If you’re taking other medications that may interact with acetaminophen
  • If you experience any unusual symptoms after taking Tylenol

Understanding Acetaminophen Concentrations

Tylenol products come in various concentrations, which can affect dosing. Here’s a quick guide to common concentrations:

  • Children’s Tylenol Oral Suspension: 160 mg/5 mL
  • Regular Strength Tylenol: 325 mg per tablet or capsule
  • Extra Strength Tylenol: 500 mg per tablet, caplet, or powder packet

Understanding these concentrations is crucial for accurate dosing, especially when switching between different formulations.

Why is concentration important?

Concentration affects how much active ingredient (acetaminophen) is in each dose. Using the correct concentration ensures that you or your child receives the intended amount of medication, avoiding underdosing or overdosing.

Tylenol Dosing for Special Populations

Certain groups may require special consideration when it comes to Tylenol dosing:

Elderly Patients

Older adults may be more susceptible to acetaminophen’s effects and may require lower doses. Healthcare providers may recommend starting with the lowest effective dose and adjusting as needed.

Patients with Liver Issues

Individuals with liver problems should use acetaminophen with caution and under the guidance of a healthcare professional. In some cases, lower doses or alternative pain relievers may be recommended.

Pregnant and Breastfeeding Women

While Tylenol is generally considered safe during pregnancy and breastfeeding, it’s always best to consult with a healthcare provider before use.

Avoiding Acetaminophen Overdose

Acetaminophen overdose can lead to serious liver damage. To prevent this, follow these guidelines:

  • Always check the active ingredients in all medications you’re taking
  • Keep a log of all acetaminophen doses taken throughout the day
  • Use the dosing device provided with liquid medications for accurate measurement
  • Never take more than one acetaminophen-containing product at a time
  • Avoid alcohol consumption when taking acetaminophen

Signs of potential acetaminophen overdose

Be aware of these symptoms, which may indicate an acetaminophen overdose:

  • Nausea and vomiting
  • Loss of appetite
  • Abdominal pain
  • Confusion
  • Yellowing of the skin or eyes (jaundice)

If you suspect an overdose, seek medical attention immediately.

Alternative Pain Relief Options

While Tylenol is effective for many types of pain and fever, there are other options available:

  • Ibuprofen (Advil, Motrin): Provides pain relief and reduces inflammation
  • Naproxen (Aleve): Offers long-lasting pain relief, especially for conditions like arthritis
  • Aspirin: Effective for pain and fever, but not recommended for children due to the risk of Reye’s syndrome
  • Topical pain relievers: Creams, gels, or patches that can be applied directly to the skin

Always consult with a healthcare provider to determine the most appropriate pain relief option for your specific situation.

Storing Tylenol Safely

Proper storage of Tylenol and other medications is crucial for maintaining their effectiveness and preventing accidental ingestion. Follow these guidelines:

  • Store at room temperature, away from heat and moisture
  • Keep out of reach of children and pets
  • Use a lockable medicine cabinet if possible
  • Don’t store in the bathroom, as humidity can affect the medication
  • Check expiration dates regularly and dispose of expired medications properly

How to dispose of unused or expired Tylenol

To safely dispose of unused or expired Tylenol:

  1. Check for local drug take-back programs in your area
  2. If unavailable, mix the medication with an undesirable substance like used coffee grounds or cat litter
  3. Place the mixture in a sealed plastic bag or container
  4. Throw the container in your household trash
  5. Remove or scratch out all personal information on the empty medication bottle before disposing of it

Understanding Pain Management

While Tylenol can be an effective tool for managing pain and fever, it’s important to understand the broader context of pain management:

Types of pain

  • Acute pain: Short-term pain that typically has a clear cause
  • Chronic pain: Long-lasting pain that persists for months or years
  • Nociceptive pain: Pain caused by damage to body tissues
  • Neuropathic pain: Pain caused by damage or dysfunction in the nervous system

Multimodal approach to pain management

Effective pain management often involves a combination of approaches:

  • Medications: Including over-the-counter and prescription options
  • Physical therapy: To improve mobility and reduce pain
  • Cognitive-behavioral therapy: To address the psychological aspects of pain
  • Lifestyle modifications: Such as exercise, diet changes, and stress reduction
  • Alternative therapies: Like acupuncture or massage

Remember that Tylenol is just one tool in the pain management toolbox. For chronic or severe pain, always work with a healthcare provider to develop a comprehensive treatment plan.

Educating Patients on Proper Tylenol Use

Healthcare providers play a crucial role in educating patients about the safe and effective use of Tylenol. Here are some key points to emphasize:

  • The importance of reading and following label instructions
  • How to properly measure liquid medications
  • The risks of exceeding recommended doses
  • The presence of acetaminophen in many combination medications
  • The need to consult a healthcare provider for persistent symptoms
  • The importance of keeping a medication log, especially when caring for children or elderly patients

Tools for patient education

Consider using these tools to enhance patient understanding:

  • Printed dosing charts
  • Visual aids showing proper measurement techniques
  • Medication tracking apps or paper logs
  • Informational brochures about acetaminophen safety

By providing clear, accessible information, healthcare providers can help ensure that patients use Tylenol safely and effectively.

TYLENOL® Dosing Guidelines | TYLENOL® Professional

Use these charts to guide proper dosage for your patients 12 and older

Jump to product:
  • TYLENOL® Regular Strength Liquid Gels
  • TYLENOL® Regular Strength Tablets
  • TYLENOL® Family, Children & Adults Oral Suspension
  • TYLENOL® Extra Strength Caplets
  • TYLENOL® Extra Strength Coated Tablets
  • TYLENOL® Extra Strength Dissolve Packs
  • TYLENOL® Rapid Release Gels
  • TYLENOL® 8HR Arthritis Pain Tablets
  • TYLENOL® 8HR Muscle Aches & Pain Tablets
  • TYLENOL® PM Extra Strength Caplets

Patients may have questions about over-the-counter analgesics. Use the information below to help them find the TYLENOL® product that’s right for them. Remember, many medicines contain the same active ingredient, so remind patients to use ONLY 1 medicine containing the same active ingredient at a time.

PROFESSIONAL DISCRETIONARY DOSING: To help encourage the safe use of acetaminophen, in 2011, the makers of TYLENOL® lowered the labeled maximum daily dose for single-ingredient TYLENOL® Extra Strength (acetaminophen) products sold in the US from 8 pills/day (4000 mg) to 6 pills/day (3000 mg). The dosage interval also changed from 2 pills every 4 to 6 hours to 2 pills every 6 hours. If pain or fever persists at the total labeled daily dose, healthcare professionals may exercise their discretion and recommend up to 4000 mg/day.*

*The efficacy and safety of TYLENOL® at 4000 mg/day are well established.

Regular Strength TYLENOL® Regular Strength Liquid Gels
ACTIVE INGREDIENT ACTIVE INGREDIENT, DOSAGE* & DIRECTIONSDOSAGE FREQUENCY*DIRECTIONS

Acetaminophen

325 mg (in each capsule)

2 capsules every 4-6 hours while symptoms last

Not to exceed 10 capsules in 24 hours, unless directed by a doctor

Total labeled daily dose:
3250 mg/day

*Consult TYLENOL® Regular Strength liquid gels packaging for dosing children under 12 years.

†The efficacy and safety of TYLENOL® at 4000 mg/day are well established.

 

Regular Strength TYLENOL® Regular Strength Tablets
ACTIVE INGREDIENT ACTIVE INGREDIENT, DOSAGE* & DIRECTIONSDOSAGE FREQUENCY*DIRECTIONS

Acetaminophen

325 mg (in each tablet)

2 tablets every 4-6 hours while symptoms last

Not to exceed 10 tablets in 24 hours, unless directed by a doctor

Total labeled daily dose:
3250 mg/day

*Consult TYLENOL® Regular Strength tablet packaging for dosing children under 12 years.

†The efficacy and safety of TYLENOL® at 4000 mg/day are well established.

 

TYLENOL® Family, Children & Adults Oral Suspension
ACTIVE INGREDIENTDOSAGE FREQUENCYDIRECTIONS

Acetaminophen

160 mg (in each 5 mL)

Take every 4 hours while symptoms lastNot to exceed 5 doses in 24 hours, unless directed by a doctor
IF POSSIBLE, USE WEIGHT TO DOSE; OTHERWISE, USE AGE.
WEIGHTAGEDOSE*
Under 24 lbsUnder 2 yearsAsk a doctor
24-35 lbs2-3 years

5 mL

36-47 lbs4-5 years

7.5 mL

48-59 lbs6-8 years

10 mL

60-71 lbs9-10 years

12.5 mL

72-95 lbs11 years

15 mL

96 lbs and overAdults and children 12 years and over

20 mL

mL = milliliter
*Or as directed by a doctor.

†The efficacy and safety of TYLENOL® at 4000 mg/day are well established.

 

Extra Strength TYLENOL® Extra Strength Caplets
ACTIVE INGREDIENT ACTIVE INGREDIENT, DOSAGE* & DIRECTIONSDOSAGE FREQUENCY*DIRECTIONS

Acetaminophen

500 mg (in each caplet)

2 caplets every 6 hours while symptoms last

Not to exceed 6 caplets in 24 hours, unless directed by a doctor

Total labeled daily dose:
3000 mg/day

*For children under 12 years, at healthcare professional’s discretion.

†The efficacy and safety of TYLENOL® at 4000 mg/day are well established.

 

Extra Strength TYLENOL® Extra Strength Coated Tablets
ACTIVE INGREDIENT ACTIVE INGREDIENT, DOSAGE* & DIRECTIONSDOSAGE FREQUENCY*DIRECTIONS

Acetaminophen

500 mg (in each tablet)

2 tablets every 6 hours while symptoms last

Not to exceed 6 tablets in 24 hours, unless directed by a doctor

Total labeled daily dose:
3000 mg/day

*For children under 12 years, at healthcare professional’s discretion.

†The efficacy and safety of TYLENOL® at 4000 mg/day are well established.

 

Extra Strength TYLENOL® Extra Strength Dissolve Packs
ACTIVE INGREDIENT ACTIVE INGREDIENT, DOSAGE* & DIRECTIONSDOSAGE FREQUENCY*DIRECTIONS

Acetaminophen

500 mg (in each powder)

2 powders every 6 hours while symptoms last

Not to exceed 6 powders in 24 hours, unless directed by a doctor

Total labeled daily dose:
3000 mg/day

*For children under 12 years, at healthcare professional’s discretion.

†The efficacy and safety of TYLENOL® at 4000 mg/day are well established.

 

Extra Strength TYLENOL® Rapid Release Gels
ACTIVE INGREDIENT ACTIVE INGREDIENT, DOSAGE* & DIRECTIONSDOSAGE FREQUENCY*DIRECTIONS

Acetaminophen

500 mg (in each gelcap)

2 gelcaps every 6 hours while symptoms last

Not to exceed 6 gelcaps in 24 hours, unless directed by a doctor

Total labeled daily dose:
3000 mg/day

*For children under 12 years, at healthcare professional’s discretion.

†The efficacy and safety of TYLENOL® at 4000 mg/day are well established.

 

Extended Release TYLENOL® 8HR Arthritis Pain Tablets
ACTIVE INGREDIENT ACTIVE INGREDIENT, DOSAGE* & DIRECTIONSDOSAGE FREQUENCY*DIRECTIONS

Acetaminophen

650 mg (in each bi-layer tablet)

2 bi-layer tablets every 8 hours with water

Not to exceed 6 bi-layer tablets in 24 hours

Total labeled daily dose:
3900 mg/day

*For children under 18 years of age, at healthcare professional’s discretion.

 

Extended Release TYLENOL® 8HR Muscle Aches & Pain Tablets
ACTIVE INGREDIENT ACTIVE INGREDIENT, DOSAGE* & DIRECTIONSDOSAGE FREQUENCY*DIRECTIONS

Acetaminophen

650 mg (in each bi-layer tablet)

2 bi-layer tablets every 8 hours with water

Not to exceed 6 bi-layer tablets in 24 hours

Total labeled daily dose:
3900 mg/day

*Do not use in children under 12 years of age.

 

PM Extra Strength TYLENOL® PM Extra Strength Caplets
ACTIVE INGREDIENTS ACTIVE INGREDIENTS, DOSAGE* & DIRECTIONSDOSAGE FREQUENCY*DIRECTIONS

Acetaminophen 500 mg
Diphenhydramine HCl 25 mg

(in each caplet)

2 caplets at bedtime

Not to exceed 2 caplets in 24 hours

Total labeled daily dose:
Acetaminophen 1000 mg/day
Diphenhydramine HCl 50 mg/day

*Do not use in children under 12 years of age.

This is not a complete list.

 

Dosage Chart: Acetaminophen (Tylenol)

Dosage Chart: Acetaminophen (Tylenol)

  • New to the Area?
  • Well Care / Annual Check-Ups
  • “Get Acquainted” Visits
  • Lab Work
  • Recommended Health Maintenance Schedule
  • Dosage Chart: Acetaminophen (Tylenol)
  • Dosage Chart: Ibuprofen (Motrin/Advil)
  • Vaccination Policy

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Acetaminophen may be less upsetting to the stomach than ibuprofen. Therefore, in general, use of acetaminophen is preferable to ibuprofen if the patient has stomach upset or is not drinking well.

In case of doubt: First, read the package label. If uncertainty still exists, call the office.


 Age0-3 mos4-11 mos12-23 mos2-3 yrs4-5 yrs6-8 yrs9-10 yrs11-12 yrs12+ yrs
 Weight in pounds6-1112-1718-2324-3536-4748-5960-7172-9596+
Concentration          
5 ml =
160 mg
Children’s Tylenol Suspension
mL
1. 252.53.7557.51012.51520
1 tab =
80 mg
Children’s Tylenol Melt-aways
# of tabs
1 ½234568
1 tab =
160 mg
Junior Tylenol Melt-aways
# of tabs
11 ½22 ½34
1 tab =
325 mg
Tylenol (regular adult)
# tabs
½111 ½2
1 tab =
500 mg
Tylenol (extra strength adult)
# tabs
½½111 ½
1 tab =
650 mg
Tylenol (extended release adult) # tabs1

  • Check dosage form and concentration carefully!
  • When choosing dose, weight is more important than age.
  • Acetaminophen doses may be repeated every four hours. 5 doses in 24 hours is a reasonable maximum.
  • 1 tsp (teaspoon) = 5.0 ml

Tylenol™ – instructions for use, doses, side effects, reviews of the drug:

0.056 ‰

Analogs

All forms of release, dosages, registration certificates, drug manufacturers, drug characteristics

Product Description Tylenol™ Caplets (caplets), 500 mg) based on the label, approved by the manufacturer in 2000

Approval date: 07/31/2000

Content

  • Active substance
  • ATX
  • Pharmacological group
  • Nosological classification (ICD-10)
  • Composition and form of release
  • pharmachologic effect
  • pharmachologic effect
  • Indications
  • Contraindications
  • Use during pregnancy and lactation
  • Dosage and administration
  • Side effects
  • Precautionary measures
  • Storage conditions
  • Best before date
  • Reviews

Active ingredient

Paracetamol* (Paracetamol*)

ATX

N02BE01 Paracetamol

Pharmacological group

Anilides

Nosological classification (ICD-10)

ICD-10 code list

Composition and formulation

1 caplet contains paracetamol 500 mg; in a blister 10 pcs. , in a box 1 blister or in strips of 2 pcs., in a box 50 strips.

Pharmacological action

Pharmacological action

analgesic , antipyretic .

Inhibits cyclooxygenase, inhibits the synthesis of PG in the central nervous system and their stimulating effect on the thermoregulatory center of the hypothalamus; increases heat transfer.

Inhibits cyclooxygenase, inhibits the synthesis of PG in the central nervous system and their stimulating effect on the thermoregulatory center of the hypothalamus; increases heat transfer.

Indications

Pain of mild to moderate intensity (including headache, toothache, sore throat and general malaise), fever.

Contraindications

Hypersensitivity, severe impairment of liver and kidney function, deficiency of glucose−6-phosphate dehydrogenase, children’s age (up to 12 years).

Use during pregnancy and lactation

Acceptable, but only on medical prescription.

Dosage and Administration

Information for healthcare professionals only.
Are you a healthcare professional?

Inside, 2 caplets 3-4 times a day, but not more than 8 caplets per day.

Side effects

In rare cases, nausea, abdominal pain, allergic reactions (skin rash, itching, urticaria).

Precautions

Do not use more than 10 days for pain and 3 days as an antipyretic. It should not be taken together with other drugs containing paracetamol.

Storage conditions

At a temperature of 15–30 °C.

Keep out of reach of children.

Expiry date

4 years.

Do not use after the expiry date which is stated on the pack.

Update date: 11/21/2018

Reviews



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Information for healthcare professionals only.
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TYLENOL: instructions, reviews, analogues, price in pharmacies

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  • Indications for use
  • Side effects
  • Contraindications
  • Pregnancy
  • 9 0023 Overdose

  • Storage conditions
  • Release form
  • Ingredients

Tylenol used for colds. Tylenol belongs to the group of non-narcotic analgesics. The drug affects the centers of thermoregulation, pain, its active ingredient is paracetamol. Tylenol does not adversely affect the mucous membranes of the gastrointestinal tract, water-salt metabolism. It affects the centers of thermoregulation and pain, thereby reducing body temperature and removing pain. This medicine does not cause retention of sodium and water ions in the body. In addition, it is completely harmless to the digestive tract, the walls of which are usually affected by other similar drugs.

Indications for use

The drug Tylenol is effective in fever associated with infections, helps with toothache, headache, as well as pain caused by arthralgia, migraine, myalgia that occurs with algomenorrhea.

Directions for use
By mouth Tylenol is taken one to two hours after a meal. Children from 12 years old, weighing more than 40 kg and adults are prescribed Tylenol in a single dosage of 500 mg. Take Tylenol about 4 times a day. Therapy lasts 5-7 days. If the patient suffers from a violation of the liver, kidneys or Gilbert’s syndrome, he needs to adjust the dose down. The same applies to older patients. In addition to reducing the dose of Tylenol for such patients, it is practiced to increase the intervals between doses. Children up to six months, weighing up to 7 kg are prescribed 350 mg of Tylenol; children under 1 year old, weighing up to 10 kg are given 500 mg of Tylenol; children under three years old, weighing up to 15 kg give 750 mg; up to 6 liters, weighing up to 22 kg – 1 g; children 9l. , weighing up to 30 kg give 1.5 g of Tylenol; children up to 12 liters – 2 g. Suspension for children 6-12 liters. give 10-20 ml; children 1-6 years old. – 5-10 ml; children from three months to one year are given 2.5-5 ml. For children under 3 months, the dosage of Tylenol is determined individually. Give children a suspension 4 times a day. Without medical supervision, the drug can be given only for 3 days to relieve fever and no more than 5 days for pain relief. Tylenol rectal suppositories are prescribed for adults at a dosage of 500 mg, they are used no more than four times a day. Children 12-15 years old. prescribe 250-300 mg of Tylenol about four times a day; 8-12 years – 250-300 mg no more than three times a day; 6-8 years old – 750-900 mg in three doses; 4-6 years – 150 mg about 3-4 times a day; child 2-4 years old – 300-450 mg in two or three doses; 1-2 years – 80 mg of Tylenol no more than four times a day; from six months to a year – 80 mg no more than three times a day; 3-6 months

– 160 mg per day, in two divided doses.

Side effects

Tylenol side effects may cause skin rash, erythema, angioedema, dizziness, nausea, epigastric pain, agitation, hepatonecrosis, anemia, dyspnea, cyanosis, heart pain, agranulocytosis, thrombocytopenia denia, leukopenia , neutropenia. In large quantities, Tylenol can be nephrotoxic, resulting in renal colic, papillary necrosis, or interstitial nephritis.

Contraindications

:
Tylenol is contraindicated in case of allergy to it, children under one month old. Caution is observed when prescribing Tylenol to patients with renal, hepatic insufficiency, benign hyperbilirubinemia, viral hepatitis, suffering from alcoholism, diabetes, lack of glucose-6-phosphate dehydrogenase, as well as elderly patients, lactating, pregnant women, children under 3 months.

Pregnancy

:
Tylenol should not be taken during pregnancy unless the physician believes that the benefit to the mother at that time is more important than the potential harm to the fetus.

Interaction with other drugs:
Tylenol reduces the effectiveness of uricosuric drugs. The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs (decrease in the synthesis of procoagulant factors in the liver). Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a small overdose. Prolonged use of barbiturates reduces the effectiveness of paracetamol. Ethanol contributes to the development of acute pancreatitis. Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxicity. Long-term combined use of paracetamol and other NSAIDs increases the risk of developing “analgesic” nephropathy and renal papillary necrosis, the onset of end-stage renal failure. Simultaneous long-term administration of paracetamol in high doses and salicylates increases the risk of developing kidney or bladder cancer. Diflunisal increases the plasma concentration of paracetamol by 50% – the risk of developing hepatotoxicity. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Overdose

:
Overdose symptoms of Tylenol : in the first 24 hours – pallor, nausea, vomiting and abdominal pain; after 12-48 hours – damage to the kidneys and liver with the development of liver failure (encephalopathy, coma, death), cardiac arrhythmias and pancreatitis. Liver damage is possible when taking 10 g or more (in adults).
Treatment: administration of methionine orally or intravenously with N-acetylcysteine.

Storage conditions

Tylenol Store at 15-30°C.

Formulation

Capsules, effervescent powder for oral solution [children], solution for infusion, oral solution [children], syrup, rectal suppositories, rectal suppositories [children], oral suspension , suspension.