Can i take ibuprofen with etodolac: Etodolac and ibuprofen Interactions – Drugs.com

12.01.202127.07.2023 by alexxlab

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Etodolac and ibuprofen Interactions – Drugs.com

This report displays the potential drug interactions for the following 2 drugs:

etodolac
ibuprofen

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Consumer
Professional

Interactions between your drugs

Using ibuprofen together with etodolac is generally not recommended. Combining these medications may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation. Gastrointestinal perforation is a potentially fatal condition and medical emergency where a hole forms all the way through the stomach or intestine. You should take these medications with food to lessen the risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. Your doctor may also be able to recommend medications to help protect the stomach and intestine if you are at high risk for developing serious gastrointestinal complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition.
This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit.
It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy,
and can have potentially adverse consequences.

The recommended maximum number of medicines in the ‘nonsteroidal anti-inflammatories’ category to be taken concurrently is usually one.
Your list includes two medicines belonging to the ‘nonsteroidal anti-inflammatories’ category:

etodolac
ibuprofen

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks.
Always consult your healthcare provider before making changes to your medications or dosage.

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Differences, similarities, and which is better for you

No one wants to live with discomfort or pain for extended periods of time, or at all for that matter. Fortunately, prescription and over-the-counter pain relievers are accessible at your nearest drug store. While they’re not as strong as opioid pain relievers, which require a more in-depth medical evaluation and prescription, NSAIDs like etodolac or ibuprofen are effective for treating mild to moderate pain.

Otherwise known as nonsteroidal anti-inflammatory drugs, NSAIDs work by blocking the production of prostaglandins. Your body may respond to certain medical conditions by producing prostaglandins, which are the chemicals responsible for pain, inflammation, and fever. NSAIDs block prostaglandin-producing enzymes—COX-1 and COX-2—to control the body’s inflammatory response and reduce pain.

Etodolac and ibuprofen are classified as NSAIDs. However, they have some important differences.

What are the main differences between etodolac and ibuprofen?

Etodolac is sometimes known by its (now discontinued) brand name, Lodine. It is available as a generic drug and can only be obtained with a doctor’s prescription.

Etodolac has a half-life of around six to seven hours and reaches peak concentrations in the blood one to two hours after ingesting it. It is usually taken two to three times daily for pain from arthritis. There is also an etodolac extended-release tablet that has a longer half-life of around eight hours and can be taken once daily.

Ibuprofen is a more common NSAID that is available over-the-counter (OTC). Higher strengths of ibuprofen are also available with a doctor’s prescription. Popular brand names of ibuprofen include Advil, Motrin, and Midol.

Ibuprofen reaches peak blood levels within one to two hours after taking it. However, unlike etodolac, ibuprofen has a shorter half-life of around two hours. Prescription-strength ibuprofen comes in a tablet that’s usually taken three to four times daily. The OTC version comes in oral tablets, capsules, and liquid suspensions.

Conditions treated by etodolac and ibuprofen

Etodolac and ibuprofen are labeled to treat pain. They’re commonly taken to treat mild to moderate acute pain from dental procedures, migraines, or muscle aches (myalgia).

Etodolac and ibuprofen are especially useful and FDA approved for treating pain and inflammation from osteoarthritis and rheumatoid arthritis. Higher strengths are usually needed to address more severe joint pain or bone pain associated with arthritis. In some cases, children above the recommended age limit can also be treated with these NSAIDs for juvenile idiopathic arthritis.

Over-the-counter ibuprofen is labeled to treat fever and menstrual cramps (primary dysmenorrhea). An injectable form of ibuprofen called NeoProfen is used to treat patent ductus arteriosus (PDA), a type of heart defect, in premature infants.

Is etodolac or ibuprofen more effective?

Both etodolac and ibuprofen are effective NSAIDs for pain relief. They both block cyclooxygenase (COX) enzymes to control inflammation and reduce pain in those with arthritis. However, the effects of etodolac last slightly longer. Therefore, some people may prefer etodolac for its lower-frequency dosing.

In a double-blind study comparing etodolac and ibuprofen, 1,446 patients with rheumatoid arthritis were given either 150 mg of etodolac twice daily, 500 mg of etodolac twice daily, or 600 mg of ibuprofen four times daily. Both dosages of etodolac were found to be similar in effectiveness to the ibuprofen dosage. In terms of side effects, those taking etodolac experienced less indigestion, rash, and stomach bleeding than those taking ibuprofen. However, this may be related to the amounts of drug patients were given.

While no other clinical trials have directly compared etodolac and ibuprofen, different studies have compared other NSAIDs to etodolac or ibuprofen. One meta-analysis found that the maximum daily dose of diclofenac is more effective than the maximum daily doses of ibuprofen, naproxen, and celecoxib (but the lowest effective dose of NSAIDs is always recommended). Another meta-analysis found that certain NSAIDs like piroxicam and azapropazone have a high risk of toxicity while low-dose ibuprofen has a low risk of toxicity. Overall, it could be said that NSAIDs tend to differ more in safety rather than effectiveness.

Because of the wide array of options for pain, it’s important to consult a healthcare provider for the best treatment option. A doctor or healthcare provider can provide the appropriate medical advice for specific medical conditions.

Coverage and cost comparison of etodolac vs. ibuprofen

Generic etodolac tablets are usually covered by Medicare and insurance plans. If you have medical conditions like arthritis, insurance plans will likely cover etodolac for pain. The average retail cost of etodolac can vary depending on the dose, but you can pay around $50 for etodolac by using a SingleCare coupon at participating pharmacies.

Since ibuprofen is available over-the-counter, some forms may not be covered by insurance plans. However, most Medicare Part D and insurance plans should cover prescription-strength ibuprofen tablets depending on the treatment regimen. In general, ibuprofen is more affordable than etodolac. Use a SingleCare coupon for ibuprofen if you have a prescription from your healthcare provider.

Common side effects of etodolac vs. ibuprofen

The most common side effects of NSAIDs, including etodolac and ibuprofen, are nausea, indigestion (dyspepsia), constipation, diarrhea, and abdominal or stomach pain. Other than gastrointestinal side effects, NSAIDs can also cause dizziness, swelling in the hands or feet (edema), headache, rash, and ringing in the ears (tinnitus). Most side effects of etodolac and ibuprofen are mild and go away on their own.

Serious side effects of NSAIDs may include allergic reactions, such as severe rash or anaphylaxis, from active or inactive ingredients. Other serious side effects include gastrointestinal adverse effects such as stomach bleeding and peptic ulcers. Consult your healthcare provider if you experience blood in the stool, weight loss, or severe abdominal pain.

This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.

Source: DailyMed (Etodolac), DailyMed (Ibuprofen)

Drug interactions of etodolac vs. ibuprofen

Because they block the COX-1 enzyme, which plays a role in platelet production and blood clots, NSAIDs can interfere with the effects of blood thinners. NSAIDs may increase the risk of bleeding from antiplatelet agents like aspirin and anticoagulants like warfarin.

Etodolac and ibuprofen can cause the body to retain fluid and affect the function of the kidneys. As a result, these NSAIDs can increase blood pressure. If you’re also taking high blood pressure (antihypertensive) medication, such as lisinopril or losartan, your blood pressure may need to be monitored while taking an NSAID.

Etodolac and ibuprofen can affect how cyclosporine, digoxin, or methotrexate are cleared from the body. Taking an NSAID could lead to an increased risk of cyclosporine, digoxin, or methotrexate toxicity.

Find other possible drug interactions below.

Consult a healthcare professional for other possible drug interactions.

Warnings of etodolac and ibuprofen

Etodolac and ibuprofen, like other NSAIDs, can increase the risk of serious cardiovascular thrombotic events such as heart attack and stroke. NSAID use should be avoided or monitored in people with cardiovascular problems like heart failure, heart disease, and high blood pressure.

The use of etodolac or ibuprofen can lead to an increased risk of serious gastrointestinal (GI) adverse events, such as stomach bleeding and peptic ulcers. Without proper treatment, inflammation, and bleeding in the GI tract can be fatal. Older people may have a higher risk of serious GI adverse events.

NSAIDs should not be used right before or after a heart procedure called coronary artery bypass graft (CABG) surgery.

Those with kidney disease may be at an increased risk of further kidney problems while taking NSAIDs.

Consult your healthcare provider for other precautions before taking an NSAID.

Frequently asked questions about etodolac vs. ibuprofen

What is etodolac?

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It is FDA approved to treat osteoarthritis and rheumatoid arthritis in adults. Generic etodolac can only be obtained with a prescription.

What is ibuprofen?

Ibuprofen is commonly known by brand names such as Advil and Motrin. It is available over-the-counter to treat mild to moderate pain, fever, and menstrual cramps. Higher-strength ibuprofen can be obtained with a prescription to treat pain and inflammation from osteoarthritis and rheumatoid arthritis.

Are etodolac and ibuprofen the same?

Etodolac and ibuprofen are not the same. While they’re both NSAIDs, they have differences in dosing and how they’re used. Etodolac is a prescription drug primarily used for adults with arthritis. Ibuprofen is more accessible as an over-the-counter drug for mild pain and fever.

Is etodolac or ibuprofen better?

The better NSAID depends on the dose you take and what you’re taking it for. Compared to ibuprofen, etodolac lasts longer in the body, and thus, it can be taken fewer times throughout the day. However, it may be more expensive than ibuprofen. Based on your overall condition, your doctor may recommend one over the other.

Can I use etodolac or ibuprofen while pregnant?

Etodolac and ibuprofen are not generally recommended during pregnancy. The use of NSAIDs during pregnancy is associated with an increased risk of birth defects or miscarriage, especially during late pregnancy. Consult your healthcare provider if you are considering treatment options while pregnant.

Can I use etodolac or ibuprofen with alcohol?

Minimal alcohol consumption may be fine on occasion while taking an NSAID. However, drinking excessive amounts of alcohol can lead to an increased risk of gastrointestinal adverse effects with NSAIDs. Alcohol and NSAIDs can irritate the stomach and intestinal lining, which could lead to ulcers or bleeding.

Is etodolac a pain killer?

Etodolac is an effective pain killer. It is most effective for treating pain and inflammation caused by arthritis. It is also useful for treating acute pain after certain procedures such as dental surgery.

Is etodolac stronger than naproxen?

The effectiveness of NSAIDs depends on the dose taken, among other factors. All things being equal, etodolac and naproxen are comparable in terms of effectiveness. According to double-blind studies, etodolac and naproxen are equally effective for treating rheumatoid arthritis. Both drugs are also well tolerated in terms of side effects.

Etodolac vs Ibuprofen: Differences, Similarities & What’s Best for You – Drug Vs. Friend

Home >> Drug Vs. Friend >> Etodolac vs Ibuprofen: Differences, Similarities & What’s Best for You

Drug Vs. Friend

Nobody wants to live with discomfort or pain for an extended period of time, or in general for that matter. Luckily, prescription and over-the-counter painkillers are available at your local pharmacy. Although they are not as strong as opioid painkillers, which require more careful medical examination and prescription, NSAIDs such as etodolac or ibuprofen are effective for treating mild to moderate pain.

Also known as non-steroidal anti-inflammatory drugs, NSAIDs block the production of prostaglandins. Your body can respond to certain diseases by producing prostaglandins, which are chemicals that cause pain, inflammation, and fever. NSAIDs block the prostaglandin-producing enzymes COX-1 and COX-2 to control the body’s inflammatory response and reduce pain.

Etodolac and ibuprofen are NSAIDs. However, they have several important differences.

What are the main differences between etodolac and ibuprofen?

Etodolac is sometimes known by its (now discontinued) trade name Lodine. It is available as a generic drug and can only be obtained with a doctor’s prescription.

Etodolac has a half-life of six to seven hours and reaches peak blood concentrations one to two hours after ingestion. It is usually taken two to three times a day for arthritis pain. There is also an extended release tablet of etodolac that has a longer half-life of about eight hours and can be taken once a day.

Ibuprofen is the more common NSAID available over the counter (OTC). Higher doses of ibuprofen are also available by prescription. Popular brands of ibuprofen include Advil, Motrin, and Midol.

Ibuprofen peaks in the blood within one to two hours after ingestion. However, unlike etodolac, ibuprofen has a shorter half-life of approximately two hours. Prescription ibuprofen comes in tablets that are usually taken three to four times a day. The over-the-counter version is available as oral tablets, capsules, and liquid suspensions.

Main differences between etodolac and ibuprofen
	etodolac
Drug class	Non-steroidal anti-inflammatory drugs (NSAIDs)	Non-steroidal anti-inflammatory drugs (NSAIDs)
Brand/generic status	Generic available (brand discontinued)	Brands and generics available
What is a brand name?	Lodin	Advil, Motrin, Midol
What form(s) does the drug come in?	Oral capsules Oral tablet Oral tablet, extended release	Oral capsules Oral tablet Oral liquid Injection (NeoProfen)
What is the standard dosage?	For pain: 200 to 400 mg every 6 to 8 hours as needed. Do not exceed the maximum dose of 1200 mg per day. For osteoarthritis or rheumatoid arthritis: immediate release 300 mg two to three times daily or 400 to 500 mg twice daily. Extended release 400 to 1000 mg once daily. Do not exceed the maximum dose of 1200 mg per day.	For pain: 200 to 400 mg every 4 to 6 hours as needed. Do not exceed the maximum dose of 1200 mg per day unless directed by a physician. For osteoarthritis or rheumatoid arthritis: 400 to 800 mg three to four times daily. Do not exceed the maximum dose of 3200 mg per day.
How long does a typical treatment take?	The duration of treatment depends on the state of health, the severity of the pain and other factors. Treatment may be short term or long term.	The duration of treatment depends on the state of health, the severity of the pain and other factors. Treatment may be short term or long term.
Who usually takes this medicine?	Adults and children 6 years of age and older	Adults and children 6 months of age and older

Conditions treated with etodolac and ibuprofen pain relief.

They are usually taken to relieve mild to moderate acute pain during dental procedures, migraine or muscle pain (myalgia).

Etodolac and ibuprofen are particularly useful and FDA approved for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. Stronger drugs are usually needed to manage more severe joint or bone pain associated with arthritis. In some cases, children over the recommended age may also be treated with these NSAIDs for juvenile idiopathic arthritis.

OTC ibuprofen is used to treat fever and menstrual cramps (primary dysmenorrhea). An injectable form of ibuprofen called NeoProfen is used to treat patent ductus arteriosus (PDA) in premature babies.

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90 044 No

Condition	Etodolac	Ibuprofen
Pain	yes	yes
Osteoarthritis	yes	yes
Rheumatoid ny arthritis	yes	yes
Juvenile idiopathic arthritis	yes	yes
Fever	No	yes
Primary dysmenorrhea	No	yes
Patent ductus arteriosus	yes