What are the potential side effects of taking cefdinir 300 mg? Learn about the common, serious, and long-term side effects, as well as how to avoid them.

Cefdinir 300 mg Side Effects: A Comprehensive Overview

Cefdinir, sold under the brand name Omnicef, is a third-generation cephalosporin antibiotic used to treat various bacterial infections such as bronchitis, sinusitis, pharyngitis (sore throat), and urinary tract infections (UTIs). While cefdinir is generally well-tolerated, it can cause a range of side effects, from mild to serious. In this comprehensive article, we will explore the common, serious, and long-term side effects associated with cefdinir 300 mg, as well as provide strategies to help you avoid them.

Common Cefdinir 300 mg Side Effects

The most commonly reported side effects of cefdinir 300 mg include:

• Diarrhea: Cefdinir can disrupt the balance of good and bad bacteria in the gut, leading to diarrhea. This is a relatively common side effect, occurring in up to 10% of patients taking cefdinir.
• Yeast infection: The antibiotic properties of cefdinir can also disrupt the natural balance of yeast in the body, leading to vaginal yeast infections in women.
• Headache: Cefdinir can sometimes cause headaches, reported in up to 5% of patients.
• Nausea and vomiting: Some patients may experience mild gastrointestinal side effects, such as nausea and vomiting, while taking cefdinir.

Serious Cefdinir 300 mg Side Effects

While less common, cefdinir 300 mg can also cause more serious adverse reactions, including:

• Severe allergic reaction (anaphylaxis): Cefdinir, like other antibiotics, can trigger a severe, life-threatening allergic reaction in some individuals. Seek immediate medical attention if you experience symptoms such as difficulty breathing, swelling of the face or throat, or severe rash.
• Stevens-Johnson syndrome: This rare, serious skin condition can be triggered by certain medications, including cefdinir. Symptoms include a painful rash, blisters, and peeling skin.
• Clostridium difficile (C. diff) infection: Cefdinir can disrupt the natural balance of gut bacteria, leading to the overgrowth of C. diff, a potentially severe and recurrent bacterial infection. Seek medical attention if you develop severe or persistent diarrhea while taking cefdinir.

Long-Term Cefdinir 300 mg Side Effects

Most side effects associated with cefdinir 300 mg are short-term and resolve once the medication is stopped. However, there are a few potential long-term effects to be aware of:

• Antibiotic resistance: Repeated or prolonged use of cefdinir can contribute to the development of antibiotic-resistant bacteria, making future infections more difficult to treat.
• Kidney damage: In rare cases, cefdinir can cause kidney damage, particularly in elderly patients or those with pre-existing kidney problems.
• Intestinal dysbiosis: The disruption of gut bacteria caused by cefdinir can lead to long-term imbalances in the gut microbiome, potentially contributing to digestive issues or other health problems.

Avoiding Cefdinir 300 mg Side Effects

To minimize the risk of side effects when taking cefdinir 300 mg, consider the following strategies:

1. Inform your healthcare provider: Be sure to tell your doctor about any medical conditions you have, as well as any other medications or supplements you are taking, as these can increase the risk of interactions and side effects.
2. Take as directed: Follow your healthcare provider’s instructions carefully regarding the dosage, frequency, and duration of cefdinir treatment. Do not stop taking the medication without consulting your doctor.
3. Maintain good hygiene: Wash your hands frequently, especially before and after using the restroom, to help prevent the spread of infection and reduce the risk of C. diff.
4. Consider probiotics: Taking a probiotic supplement may help restore the balance of gut bacteria and reduce the risk of antibiotic-associated diarrhea or yeast infections.
5. Monitor for side effects: Be vigilant for any adverse reactions and report them to your healthcare provider immediately, especially if they are severe or persistent.

Cefdinir 300 mg Side Effects in Seniors

Elderly patients may be at a higher risk of certain side effects when taking cefdinir 300 mg, particularly kidney damage and C. diff infections. Healthcare providers may adjust the dosage or closely monitor kidney function in older adults to minimize these risks.

How Long Do Cefdinir 300 mg Side Effects Last?

The duration of cefdinir 300 mg side effects can vary depending on the specific reaction and the individual’s response to the medication. In general:

• Mild side effects: These, such as diarrhea, nausea, and headache, usually resolve within a few days to a week after completing the cefdinir treatment.
• Severe side effects: Serious reactions, like allergic responses or C. diff infections, may take longer to resolve and may require medical intervention.
• Long-term effects: The disruption of gut bacteria and potential for antibiotic resistance can have lasting impacts, even after cefdinir treatment has ended.

Cefdinir 300 mg Warnings and Precautions

Before taking cefdinir 300 mg, be sure to inform your healthcare provider if you have any of the following conditions:

• Allergies to cefdinir or other cephalosporin antibiotics
• Kidney disease or impairment
• Gastrointestinal conditions, such as colitis or inflammatory bowel disease
• Seizure disorders or a history of seizures

Additionally, avoid consuming alcohol while taking cefdinir, as this can increase the risk of side effects.

Cefdinir 300 mg Drug Interactions

Cefdinir can interact with a variety of medications, including:

• Proton pump inhibitors (PPIs): These medications, such as omeprazole (Prilosec) and pantoprazole (Protonix), can reduce the absorption of cefdinir, potentially decreasing its effectiveness.
• Antacids: Antacids containing aluminum, calcium, or magnesium can also interfere with cefdinir absorption.
• Blood thinners: Cefdinir may interact with certain blood-thinning medications, such as warfarin, increasing the risk of bleeding.

Be sure to inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking to avoid potential interactions.

How to Avoid Cefdinir 300 mg Side Effects

To help minimize the risk of side effects when taking cefdinir 300 mg, consider the following tips:

1. Take cefdinir with food: This can help reduce gastrointestinal side effects, such as nausea and diarrhea.
2. Stay hydrated: Drink plenty of water and other fluids to help prevent dehydration from diarrhea.
3. Avoid antacids and PPIs: If possible, take cefdinir at least 2 hours before or after using these types of medications.
4. Consider probiotics: Taking a probiotic supplement may help restore the balance of gut bacteria and reduce the risk of antibiotic-associated diarrhea or yeast infections.
5. Monitor for side effects: Be vigilant for any adverse reactions, especially during the first few days of treatment, and report them to your healthcare provider immediately.

By understanding the potential side effects of cefdinir 300 mg and taking proactive steps to avoid them, you can help ensure a safe and effective treatment experience.

Cefdinir Interactions Checker – Drugs.com

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There are 45 drugs known to interact with
cefdinir, along with
7 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
3 are major, and 42 are moderate.

Does cefdinir interact with my other drugs?

Enter other medications to view a detailed report.

• View all 45 medications that may interact with cefdinir
• View cefdinir alcohol/food interactions (1)
• View cefdinir disease interactions (7)

Most frequently checked interactions

View interaction reports for cefdinir and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• Aspirin Low Strength (aspirin)
• Augmentin (amoxicillin / clavulanate)
• Benadryl (diphenhydramine)
• Claritin (loratadine)
• CoQ10 (ubiquinone)
• Cymbalta (duloxetine)
• Eliquis (apixaban)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Flexeril (cyclobenzaprine)
• Flonase (fluticasone nasal)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• Metoprolol Tartrate (metoprolol)
• MiraLAX (polyethylene glycol 3350)
• Mucinex (guaifenesin)
• Norco (acetaminophen / hydrocodone)
• ProAir HFA (albuterol)
• Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
• Protonix (pantoprazole)
• Singulair (montelukast)
• Symbicort (budesonide / formoterol)
• Synthroid (levothyroxine)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D2 (ergocalciferol)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zofran (ondansetron)
• Zyrtec (cetirizine)

Cefdinir alcohol/food interactions

There is 1 alcohol/food interaction with cefdinir.

Cefdinir disease interactions

There are 7 disease interactions with cefdinir which include:

• colitis
• renal dysfunction
• diabetes
• nitroprusside tests
• dialysis
• liver disease
• seizure disorders

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• Breastfeeding
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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Cefdinir side effects and how to avoid them

Diarrhea, yeast infection, and headache are common cefdinir side effects, but this antibiotic can also cause a rash and C.Diff

Common cefdinir side effects | Diarrhea | Yeast infection | Serious side effects | Rash | C.Diff | Side effects in seniors | How long do side effects last? | Warnings | Interactions | How to avoid side effects

Cefdinir (brand name: Omnicef) is a third-generation cephalosporin antibiotic used to treat certain bacterial infections such as bronchitis, sinusitis, pharyngitis (sore throat), and urinary tract infections (UTIs). It works by killing harmful bacteria throughout the body. It comes in both capsule and oral suspension form and is usually taken for up to 10 days, depending on the type of infection being treated.

Common side effects include diarrhea, vomiting, and headache. Serious adverse reactions are less common and include severe allergic reactions, Steven-Johnson’s syndrome, and Clostridium difficile (C. difficile) infections. Drug interactions are also possible when taking cefdinir. Be sure to tell your healthcare provider if you have any medical conditions or are taking any medications before taking cefdinir.

RELATED: Learn more about cefdinir |Get cefdinir discounts

Common side effects of cefdinir

The most common side effects of cefdinir include:

• Diarrhea 
• Yeast infection (candidiasis) 
• Nausea and/or vomiting
• Headache
• Abdominal pain
• Inflammation of the vagina (vaginitis)
• Rash 
• Indigestion/Flatulence

Some clinically significant laboratory changes that might be seen include:

• Increased white blood cells in urine 
• Increased levels of protein in the urine (proteinuria)
• Microscopic amounts of blood in the urine (microhematuria) 
• Increased blood sugar (glucose)
• High levels of eosinophils (eosinophilia), which are a special type of white blood cells
• Elevated liver enzymes i. e. alanine aminotransferase (ALT) or aspartate aminotransferase (AST)

Diarrhea

In the same adult clinical trial mentioned above, 15% of adults and adolescents experienced diarrhea. 

The pediatric clinical trial showed 8% of children being treated with cefdinir experienced diarrhea and 0.8% experienced abdominal pain. The rates of diarrhea were highest in patients younger than 2 years old (17%).

If diarrhea is severe during treatment with cefdinir, consult your healthcare provider to rule out a C. difficile infection.

Yeast infection

Cefdinir destroys harmful bacteria in the body, but can also destroy the good bacteria. This may result in oral thrush and vaginal yeast infections during treatment with cefdinir. 

A clinical trial of 5,093 adults and adolescents taking 600 mg of cefdinir per day found that 4% of women experienced a vaginal yeast infection during treatment. In the same group, there was a 0.2% occurrence of yeast infections unrelated to the vagina.

Another trial of 2,289 pediatric patients showed vaginal yeast infections in 0.3% of girls being treated with cefdinir and fungal skin infections in 0.9% of all children.

RELATED: How to prevent yeast infections from antibiotics

Serious side effects of cefdinir

Serious side effects while taking cefdinir are rare but possible. These side effects include:

• Severe allergic reaction (anaphylaxis)
• Stevens-Johnson syndrome: flu-like symptoms accompanied by painful rash and blisters
• Toxic epidermal necrolysis: a rare condition causing skin peeling and blistering
• Exfoliative dermatitis: redness and peeling of large areas of skin
• C. difficile infection causing severe diarrhea and colitis
• Low neutrophils (neutropenia)
• Low platelet count (thrombocytopenia)
• Hemolytic anemia
• Aplastic anemia
• A severe immune reaction (serum sickness)
• Renal toxicity
• Liver toxicity

Cefdinir rash

Several side effects of cefdinir may be accompanied by a rash, including an allergic reaction, Stevens-Johnson syndrome, toxic epidermal necrolysis, and exfoliative dermatitis.

Clinical trials reported rash at an incidence of 0.9% in adults and adolescents being treated with cefdinir. Rash occurred in 3% of children taking this medication, although the majority of these occurrences were in children younger than 2 years old.

Seek emergency medical attention right away if rash-like symptoms are accompanied by wheezing, tightness in the chest or throat, or trouble breathing. This could be a sign of a potentially dangerous allergic reaction.

Clostridium difficile-associated diarrhea

Treatment with Cefdinir can destroy some of the bacteria in the gut. This allows other organisms such as C. difficile to grow out of control. C. difficile produces toxins that may cause swelling/inflammation in the lining of the large intestine. This inflammation is called pseudomembranous colitis. This can cause diarrhea ranging in severity from mild diarrhea to fatal colitis. Symptoms include:

• Frequent watery diarrhea that is sometimes bloody
• Pain and tenderness in the stomach
• Cramping
• Nausea
• Fever
• Loss of appetite

RELATED: Antibiotics that cause C. Difficile

Cefdinir side effects in elderly

People with multiple comorbidities may have an increased risk of side effects when treated with antibiotics, and older adults have more underlying health conditions than younger patients. However, clinical trials found cefdinir to be a safe drug for older patients, with a lower adverse reaction rate compared to young adults.

How long do cefdinir side effects last?

Most cefdinir side effects will subside during or shortly after treatment, although some may require medical attention. Yeast infections, oral thrush, and C. difficile are some examples of side effects that may need to be treated with other medications.

Severe allergic reactions require immediate medical attention. Signs of a severe allergic reaction include:

• Rash or hives
• Swollen or blistered areas of skin
• Red, peeling skin
• Wheezing
• Chest tightness
• Swelling of the mouth, face, lips, throat, or tongue
• Difficulty breathing

Cefdinir contraindications and warnings

Cefdinir may not be appropriate for everyone. Discuss any medical conditions with your healthcare provider before starting treatment, especially if you have ever had:

• Kidney disease or a history of dialysis
• Allergies to other antibiotics, especially cephalosporins and penicillins
• Colitis
• Diabetes (oral suspension contains sucralose)
• Seizure disorders

Kidney disease

Use caution in patients with a creatinine clearance of <30mL/min. Dosage should be reduced in these patients with kidney problems. There is evidence that cephalosporin antibiotics may cause seizures in patients with renal impairment whose dosage was not reduced.

Colitis

Use caution in patients with a history of colitis. Clostridium difficile-associated diarrhea may be more severe in these patients if it occurs. 

Diabetes

Cefdinir can increase blood sugar on its own. The liquid form of cefdinir also contains sugar, which may alter blood glucose levels. Diabetic patients should avoid using cefdinir suspension to ensure that blood sugar levels aren’t altered during treatment. Careful glucose monitoring is required when Cefdinir must be used.

Withdrawal

Cefdinir does not cause dependency or withdrawal symptoms. However, like all antibiotics, if a patient does not finish the full course of antibiotics, an infection may persist or recur.

Overdose

Overdose on any medication is possible, including cefdinir. Signs of overdose include:

• Nausea
• Vomiting
• Stomach pain
• Diarrhea
• Seizures

If an overdose is suspected, seek emergency medical attention or call the Poison Control Center immediately. 

Children

Cefdinir is FDA-approved to treat certain bacterial infections in children as young as 2 months. It may treat bacterial ear infections (otitis media), sinusitis, pharyngitis, tonsillitis, pneumonia, and bacterial skin infections.

Pregnancy

According to the FDA, cefdinir is a pregnancy category B medication. There is no human data available to measure risk, but animal data shows no known risks or complications of taking cefdinir while pregnant. If you’re pregnant, be sure to talk to your healthcare provider about the risks before taking this medication.

Breastfeeding

Cefdinir may be taken while breastfeeding. There is no human data available to determine the risk to the infant, however, no risk is expected based on data from other cephalosporin antibiotics. It is not yet known if cefdinir affects breast milk production.

Cefdinir interactions

There are several drugs and supplements that may interact with cefdinir, according to the FDA. Be sure to tell your healthcare provider what medications, vitamins, and supplements you’re taking before beginning treatment.

• Antacids, magnesium, and iron supplements: Some antacids or supplements containing iron or magnesium may interfere with cefdinir absorption. Take 2 hours before or after Cefdinir. Patients taking iron may also experience a reddish stool discoloration (not related to bleeding). The reddish color is due to the formation of a complex between cefdinir and iron in the gut.
• Probenecid: Taking probenecid, a uric acid reducer that treats gout, may increase levels of cefdinir in the body.
• Hormonal contraceptives: Cefdinir may decrease the efficacy of hormonal birth control; use another form of birth control while taking cefdinir.
• Tetracyclines: Taking tetracyclines with cefdinir may alter the way cefdinir works inside the body.

How to avoid cefdinir side effects

Cefdinir may cause side effects, but there are ways to reduce the risk for these undesired effects. Some ways to avoid side effects while taking cefdinir include:

• Take cefdinir as directed. Follow the medical advice of your healthcare provider and instructions given by your pharmacist. Be sure to shake your liquid cefdinir before use and measure using an appropriate dosing syringe.
• Take cefdinir with or without food. You don’t have to take cefdinir with food, however, taking it with food may decrease stomach discomfort.
• Don’t skip doses. If you forget a dose of cefdinir, take the missed dose as soon as possible. If it’s almost time for your next dose, skip the missed dose. Never double up on doses, as this may cause unwanted side effects.
• Avoid antacids, magnesium, and iron supplements for at least two hours before and after taking cefdinir. Some antacids and supplements interfere with the absorption of cefdinir. Avoid taking antacids or supplements containing magnesium or iron within two hours of taking cefdinir to prevent these interactions.
• Tell your provider about all medical conditions. Cefdinir may not be the best medication for patients with certain medical conditions. Avoid taking cefdinir if you’ve had an allergic reaction to cephalosporin antibiotics in the past.
• Tell your provider what other medications you are taking. Drug interactions while taking cefdinir are possible. Tell your healthcare provider of any prescription drugs, over-the-counter medications, supplements, and herbal products before beginning treatment.
• Don’t stop taking cefdinir before you’ve finished treatment unless directed to do so by a healthcare professional. It’s important to finish your entire treatment, even if your symptoms improve. Discontinuing the medication early may cause repeat infection or antibiotic resistance.
• Store cefdinir properly. Keep this medication at room temperature away from moisture and heat and out of reach of children. Discard your unused cefdinir after treatment.

Resources

• Omnicef drug information, Federal Drug Administration (FDA)
• Cefdinir adverse reactions, Epocrates
• Cefdinir contraindications, Epocrates
• Cefdinir drug label info, DailyMed

Rinicef ​​300mg/ Rinicef ​​300mg

Trade name: Rinicef

International Nonproprietary Name: Cefdinir/Cefdinir

Presentation: capsules 300 mg.

Description: hard gelatin capsules, black opaque cap and gray opaque base.

Composition:

1 capsule contains:

active substance : cefdinir – 300.00 mg;

Pharmacotherapeutic group

Antibacterial agents for systemic use. Third generation cephalosporins. ATX code: J01DD15

Pharmacological properties.

Pharmacodynamics

The active substance cefdinir is a semi-synthetic broad-spectrum cephalosporin antibiotic of the third generation for oral administration. Like other antibiotics of the cephalosporin group, cefdinir has a bactericidal effect against susceptible microorganisms due to the inhibition of the synthesis of peptidoglycan of the bacterial cell wall by disrupting the final stage of transamination necessary for the formation of cross-links. Cefdinir is resistant to many, but not all, beta-lactamases produced by Gram-positive and Gram-negative bacteria. Due to this, many microorganisms resistant to penicillins and some cephalosporins are sensitive to cefdinir. The spectrum of action of cefdinir includes:

Aerobic Gram-positive microorganisms

Staphylococcus aureus (including beta-lactamase producing strains)

Staphylococcus pneumoniae
(only strains sensitive to penicillin)

Staphylococcus pyogenes

Aerobic gram-negative microorganisms

Haemophilus influenzae (including beta-lactamase producing strains)

Haemophilus parainfluenzae
(including beta-lactamase producing strains)

Moraxella catarrhalis (including beta-lactamase producing strains)

The following data was obtained in vitro , but their clinical significance is unknown.

Minimum inhibitory concentration (MIC) of cefdinir in in vitro
is 1 μg / ml or less in relation to (≥ 90%) strains of the following microorganisms; however, the safety and efficacy of cefdinir in the treatment of infections caused by the following microorganisms has not been demonstrated in clinical studies.

Aerobic gram-positive microorganisms

Staphylococcus epidermidis

Streptococcus agalactiae

Streptococcus viridans group

Aerobic gram-negative microorganisms

Citrobacter diversus

Escherichia coli

Klebsiela pneumoniae

Proteus mirabilis

Cefdinir is inactive against strains Pseudomonas, Enterobacter, Enterococcus and methicillin-resistant strains of staphylococci.

Method of administration and dosage

Recommended dosages and duration of treatment for infections in adults and adolescents are described in the table below. The total daily dose for the treatment of all infections is 600 mg. Dosing the drug once a day for 10 days is as effective as taking it twice a day. Once-daily dosing has not been studied for the treatment of pneumonia and skin infections, so Rinicef ​​should be taken twice daily in these cases. The capsules can be taken with or without food.

For the treatment of children (6 months – 12 years), cefdinir is used in the form of a suspension.

Adults and adolescents (ages 13 and over)

Elderly patients: does not require a change in dosing regimen, unless there is a significant impairment of renal function (CC < 30 ml / min). If CC < 30 ml / min, the drug should be taken at a dose of 300 mg once a day.

Patients with renal insufficiency

For patients with CC < 30 ml/min, cefdinir should be given at a dose of 300 mg once daily.

Hemodialysis patients

Hemodialysis promotes the elimination of cefdinir from the body. For patients on permanent hemodialysis, the recommended starting dose is 300 mg or 7 mg/kg every other day. At the end of each hemodialysis session, 300 mg (or 7 mg/kg) of cefdinir is given. Subsequent doses (300 mg or 7 mg/kg) are then given every other day.

If you miss the next dose of the drug, you should take it as soon as you remember. If this missed dose occurs at the time of the next dose, skip the missed dose and follow the previous dosing regimen, do not double the dose.

Side effect

Cefdinir is well tolerated, the identified adverse reactions were mild in nature and resolved spontaneously after discontinuation. Most withdrawals were associated with gastrointestinal disturbances, mainly manifested by diarrhea or nausea. In rare cases, the withdrawal of the drug was due to the development of a rash while taking cefdinir.

Adverse reactions are classified according to the frequency of occurrence: very often (? 1/10), often (from ? 1/100 to < 1/10), infrequently (from ? 1/1,000 to < 1/100), rarely (? 1/10,000, <1/1000), very rarely (< 1/10,000), and the frequency is unknown (the frequency cannot be established according to the available data).

Very common: diarrhea, rash, nausea.

Often: skin candidiasis, abdominal pain, leukopenia, candidal vaginitis, vaginitis, stool changes, dyspepsia, hyperkinesis, macolopapular rash, nausea, increased AST.

Adverse reactions specific to cephalosporins

Allergic reactions, anaphylaxis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, renal dysfunction, toxic nephropathy, liver dysfunction including cholestasis, aplastic anemia, hemolytic anemia, hemorrhagic disorders, false positive urine glucose test, neutropenia, pancytopenia and agranulocytosis. Pseudomembranous colitis can develop both during and after the end of the antibiotic prescription.

The use of some cephalosporins was accompanied by the development of seizures, especially in patients with impaired renal function, who were not dose recalculated. If convulsions develop during therapy, the antibiotic should be discontinued. If clinically necessary, anticonvulsant therapy may be prescribed.

According to the results of post-registration experience of use, the following adverse reactions were identified: shock, anaphylaxis (in rare cases with a fatal outcome), edema of the subglottic space and face, feeling of suffocation, serum-like syndrome, conjunctivitis, stomatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, erythema nodosum, acute hepatitis, cholestatic syndrome, lightning nasal hepatitis, liver failure, jaundice, amylase elevation, acute enterocolitis, hemorrhagic diarrhea, hemorrhagic colitis, melena, pseudomembranous colitis, pancytopenia, granulocytopenia, leukopenia, thrombocytopenia, idiopathic thrombocytopenic purpura, hemolytic anemia, acute respiratory failure, asthma attack, drug-induced pneumonia, eosinophilic pneumonia, idiopathic interstitial pneumonia, fever, acute renal failure, nephropathy, bleeding tendency, bleeding disorder, generalized thrombohemorrhagic syndrome, upper gastrointestinal bleeding, peptic ulcer, intestinal obstruction, unconsciousness, allergic vasculitis, possible cefdinir-diclofenac interaction, heart failure, chest pain, myocardial infarction, rhabdomyolysis, involuntary movements, hypertension.

In the event of the listed adverse reactions, as well as a reaction not indicated in the instructions for use, you should consult a doctor.

Contraindications

Rinicef ​​is contraindicated in patients with a history of allergy to the cephalosporin class of antibiotics and hypersensitivity to excipients in the composition of the drug.

Overdose

Data on cefdinir overdose in humans are not available.

In acute toxicity studies in rodents, a single oral dose of cefdinir at a dose of 5600 mg/kg did not lead to the development of adverse reactions. The following signs and symptoms of overdose have been observed with other beta-lactam antibiotics: nausea, vomiting, stomach discomfort, diarrhea, and convulsions.

During hemodialysis, cefdinir is removed from the body, which can be useful in case of serious toxic reactions caused by overdose, especially if the patient has impaired renal function.

Precautions

Before starting therapy with Rinicef, it is necessary to exclude the presence of a history of hypersensitivity reactions to penicillins, cephalosporins or other drugs.

In case of suspicion or confirmation of the development of Clostridium difficile -associated diarrhea, antibiotic therapy should be discontinued if it does not work on Clostridium difficile . Based on the clinical condition, the patient may be indicated for fluid replacement, administration of electrolyte and amino acid solutions, antibiotic therapy. Clostridium difficile

Rinicef, like other broad-spectrum antimicrobials (antibiotics), should be used with caution in patients with a history of colitis.

In patients with transient or persistent renal insufficiency (CC <30 ml/min), the daily dose of Rinicef ​​should be reduced, since administration at the recommended doses can lead to a significant increase in plasma concentrations and the half-life of cefdinir.

The administration of cephalosporins can sometimes lead to a positive Coombs test result.

Use during pregnancy and lactation.

Pregnancy and childbirth

Experimental reproduction studies have shown the absence of any teratogenic effect.

Data on the results of the use of cefdinir in pregnant women are not available. Cefdinir should only be used during pregnancy if there is a justified clinical need.

Data on the effect of the appointment of cefdinir on childbirth are not available.

Lactation

When prescribing cefdinir at a dose of 600 mg, it is not detected in breast milk in nursing mothers. Cefdinir is prescribed during lactation only after a careful assessment of the benefit / risk ratio for mother and child.

Influence on the ability to drive vehicles and work with mechanisms.

Rincef does not affect the ability to drive vehicles and work with mechanisms.

Interaction with other drugs

Co-administration of cefdinir and an antacid results in a decrease in the rate (C _max ) and extent (AUC) of cefdinir absorption by approximately 40%. If antacids are required during treatment with Rinicef, Rinicef ​​should be taken at least 2 hours before or 2 hours after taking the antacid.

As with other beta-lactam antibiotics, probenicide interferes with renal excretion of cefdinir when administered concomitantly, resulting in an approximately two-fold increase in AUC, a 54% increase in maximum cefdinir plasma concentration, and a prolongation of the half-life t _1/2 by 50%.

The simultaneous administration of cefdinir with iron-containing drugs containing 60 mg of elemental iron (as FeSO ₄ ), or vitamin drugs containing 10 mg of iron, reduces the absorption of cefdinir by 80% and 31%, respectively. If a patient requires iron medications during cefdinir therapy, Rinicef ​​should be taken at least 2 hours before or after taking iron medications.

There have been reports of reddish-colored stools in patients taking cefdinir. In many cases, iron-fortified foods were taken concomitantly by these patients. The reddish coloration may be due to the formation in the gastrointestinal tract of a non-absorbable complex of cefdinir or its degradation products and iron.

During treatment with cefdinir, false-positive results for urinary ketones may occur with nitroprusside, but not with nitroferricyanide. False-positive results may also be noted when determining glucose in the urine using Benedict’s solution or Fehling’s reagent (it is recommended to determine glycosuria only by the enzyme method). The use of cephalosporins can sometimes lead to a positive Coombs test result.

Storage conditions and shelf life

At a temperature not higher than 25°C.

Keep out of the reach of children!

Shelf life 3 years. Do not use after the expiry date stated on the packaging.

Holiday conditions

By prescription.

Packaging

10 capsules in a blister pack made of PVC film and flexible packaging based on aluminum foil.

1 or 2 blister packs, together with the leaflet, are placed in a cardboard pack.

Manufacturer information

Foreign production and trade unitary enterprise “Reb-Pharma”, 223216, Republic of Belarus, Minsk region, Chervensky district, settlement. Smilovichi, st. Sadovaya, 1, tel./fax: (+375) 17 240 26 35, e-mail: [email protected], http://www.rebpharma.by.

Pharmacy chain “Planet of Health” – Home delivery of pharmacy cosmetics, medical equipment and medical devices. Booking medicines and dietary supplements for pickup at a pharmacy convenient for you

Rilastil Allergy Sunscreen fluid for sensitive and reactive skin SPF 50+ 50 ml (for Istituto Ganassini S.p.A. di Ricerche Biochimiche, Italy), Spain

Code:
155869

Available

PIC solution Automatic blood pressure monitor CARDIOsimple

PIKDARE S. p.A, Italy (manufactured by Andon Health Co., Ltd. in China), China

Code:
132045

In stock

Novexpert Vitamin C Lifting cream for the skin around the eyes with a radiant effect, 15 ml

Laboratoires Novexpert (factory: Laboratoires Blc Thalgo Cosmetic), France

Code:
153927

In Stock

AVENE CLEANANCE Sunscreen Fluid for Oily Skin SPF 50+ 50 ml

PIERRE FABRE DERMO-COSMETIC, France

Code:
140576

In stock

Plaster Classic universal. with antibacterial cushion, set, mm: 25×72; 19×72; 9.5×38; 16×57; diam 22.5; No. 40

PIKDARE S.p.A., Italy

Code:
153861

In stock

NOREVA AKTIPURE EXPERT SENSI+ Soothing cream-gel for problem skin, 30 ml

Laboratoires NOREVA-LED, France, France

Code:
157836

In stock

AVENE Intense Protect Ultra-Waterproof Sun Fluid SPF50+, 150ml

PIERRE FABR DERMO-COSMETIC, France

Code:
148644

In stock

DermoFuture Serum for couperose skin with vitamin K, 20 ml

Laboratorium Kosmetyczne CANEXPOL Sp. z.o.o. (for Tenex Sp.z.o.o., Poland), Poland

Code:
122981

In stock

AVENE Sunscreen for sensitive skin SPF 50+ 50 ml

PIERRE FABRE DERMO-COSMETIC, France

Code:
140604

In stock

NOREVA AQUAREVA Moisturizing serum 24 hours, 30 ml

Laboratoires NOREVA-LED, France, France

Code:
151624

In stock

Delicate patch with antibacterial pad for sensitive skin, BOY for children mm: 19×72, no. 24

PIKDARE S.p.A., Italy

Code:
148868

In stock

AVENE B-PROTECT Sunscreen SPF 50+ 30 ml

PIERRE FABRE DERMO-COSMETIC, France

Code:
140609

In stock

DUCRAY MELASCREEN UV Sunscreen SPF 50+ 40 ml

PIERRE FABRE DERMO-COSMETIC, France

Code:
147659

In stock

A-DERMA EPITHELIALE A.H ULTRA Protective Repair Cream SPF 50+ 40 ml

PIERRE FABR DERMO-COSMETIC, France

Code:
154858

In stock

BIOCLIN DEO active Unscented deodorant spray for sensitive skin, 100 ml

FARMAGAN S. p.A. (for Istituto Ganassini S.p.A. di Ricerche Biochimiche, Italy), San Marino

Code:
123270

In stock

New

BAA Swiss Energy Immunovit Kids with vitamins and minerals chewable lozenges №60

FreiCare Swiss AG, Switzerland

Code:
144745

Available

New

BAA Swiss Energy Neuroforce Forte capsules №30

Jelpel AG, Switzerland
155040

Available

New

Zest Vision Complex dietary supplement capsules № 30

HC Clover PS S.L./XC Clover PS S.L., Spain

Code:
156545

In stock

New

Nozacar Gel Mint nasal spray 0.5 mg/g 15g №1

Lamira-Pharmakar LLC, Belarus

Code:
155582

In stock

New

AVENE HYDRANCE BOOST Concentrated Moisture Booster Serum 30ml

PIERRE FABR DERMO-COSMETIC, France

Code:
156383

In stock

New

AVENE Makeup Remover Cleansing Foam 150 ml

PIERRE FABR DERMO-COSMETIC, France

Code:
156378

In stock

New

BUBCHEN Baby Puder, 100 g

The Power Company, Switzerland

Code:
158816

In stock

New

DERMA Red OFF Anti-Wrinkle Night Cream-Mask 50 ml

Pollena Ewa S. A., Poland

Code:
151043

In stock

New

EVA DERMA Red OFF Anti-Wrinkle Day Cream 50 ml

Pollena Ewa S.A., Poland

Code:
151044

In stock

New

EVA DERMA Red OFF Cleansing foam 150 ml

Pollena Ewa S.A., Poland

Code:
151046

Available

New

EVA DERMA Red OFF Soothing tonic 200 ml

Pollena Ewa S.A., Poland

Code:
151045

In stock

New

Lactacyd Classic Lotion Lactacyd classic 2020 for daily intimate hygiene 125 ml

Setes Cosmetics LLC, Russian Federation

Code:
158683

In stock

New

LV Micellar water for skin cleansing and make-up removal 250ml

Berner Oy, Finland

Code:
159138

In stock

New

MASSTIGE Moisturizing toner “Volcanic Mineral Water” 200 ml

MASTIZH GROUP LLC, Belarus

Code:
158236

In stock

New

MAXLER Food supplement “Beauty Collagen” flavor: flavor: citrus, liquid, 450 ml

GTI USA LLC, USA (Vitaquest International LLC), USA

Code:
158225

Available

New

Novexpert Poly Spot corrector against age spots 2 ml

Laboratoires Novexpert (manufacturer: Laboratoires Blc Thalgo Cosmetic), France

Code:
157870

In stock

New

One Touch Classic Condoms, 3 pcs

FORANS Medical GmbH (Thai Nippon Rubber Industry Public Company
Ltd. ) Thailand, Thailand

Code:
158819

In stock

New

One Touch Lights Condoms, 12 pcs

FORANS Medical GmbH (Thai Nippon Rubber Industry Public Company
Ltd.) Thailand, Thailand

Code:
158821

In stock

New

Rilastil Sun System Water Touch Mattifying Sun Cream SPF 50+ 50 ml

BIOCLIN S.r.l. (for Istituto Ganassini S.p.A. di Ricerche Biochimiche, Italy), Italy

Code:
155873

In Stock

New

Rilastil Sun System Water Touch Moisturizing Tinted Fluid SPF 50+ 50 ml

DERMOFARM S.A.U. (for Istituto Ganassini S.p.A. di Ricerche Biochimiche, Italy), Spain

Code:
155871

In stock

New

TOPICREM AC HYDRA AK Compensating moisturizing cream, 40 ml

Laboratoires NIGY, France

Code:
158082

In stock

New

TOPICREM HYDRA+ Ultra Moisturizing Serum, 30 ml

Laboratoires NIGY, France

Code:
158083

In stock

New

“DRYDRY Woman” perfumed antiperspirant / remedy for normal and profuse sweating for women, 50ml

LEXIMA AB, Sweden

Code:
158574

In stock

New

Geviran tablets 800mg No. 10×3

Pharm.zad Polpharma JSC, Poland

Code:
No. 100002 Rubikon LLC, Belarus

Code:
106891

In stock

New

Desloratadine KRKA tablets 5mg №10×1

KRKA dd, Slovenia

Code:
158601

In stock

New

Desloratadine KRKA tablets 5mg No. 10×3

KRKA dd, Slovenia

Code:
158605

In stock

New

Regenerating protein cocktail for cancer patients (with strawberry flavor), 400 g

Leovit Nutrio LLC, Russia

Code:
158590

In stock

New

Protein detox cocktail for cancer patients (with neutral taste), 400 g

Leovit Nutrio OOO, Russia

Code:
158589

In stock

New

MAXLER dietary supplement “D3K2 Gammiz” flavor: orange, chewing candy 2g №90

GTI USA LLC, USA (Vitaquest International LLC), USA

900 02 Code:
158227

In stock

New

MAXLER BAD “Slip Gummies with melatonin” taste: passion fruit, gelatin 3 g each No. 60

GTI USA LLC, USA (Vitaquest International LLC), USA

9000 2 Code:
158226

In stock

New

MAXLER Biologically active food supplement “D3K2 Gummies” flavor: strawberry, chewing candy 2 g №90

GTI USA LLC, USA (Vitaquest International LLC ), USA 9 0007

Code:
158228

In stock

New

MAXLER Dietary supplement “Vitamin C Gummies 500mg” flavor: orange, chewing candy 3 g №60

GTI USA LLC, USA (Vitaquest International LLC), USA

90 002 Code:
158229

In stock

New

MAXLER Biologically active food supplement “Calcium Magnesium Zinc + D3” tablets 1.61 g № 90

GTI USA LLC, USA (Vitaquest International LLC), USA 90 007

Code:
158230

In stock

New

MAXLER Biologically active food supplement Hair Nails Skin, 1 g tablets №60

GTI USA LLC, USA (Vitaquest International LLC), USA

Code:
158250

In stock

New

EQUILIBRA Tricologica Hair restoration and strengthening set

EQUILIBRA s. r.l., Italy

Code:
158896

In stock

New

Detoxification drink for cancer patients (with neutral taste), 400 g

Leovit Nutrio LLC, Russia

Code:
158593

In stock

New

AVENE Scrub gel soft cleansing for face 75 ml

PIERRE FABRE DERMO-COSMETIQUE Laboratoires Dermatologiques Avene, France

Code:
158119

In stock

New

Bella Baby Happy Junior Universal hygienic panties for children, 10 pcs

Bella LLC, Russia

Code:
157752

In stock

Beauty and care

Total: 2900 products

Dermacosmetics

Total: 1293 products

Medicines and prophylactic products

Total: 3354 products

Products for children and parents

Total: 1043 products

Medical products and devices

Total: 704 products

Vitamins and dietary supplements

Total: 936 products 900 07

Optics

Total: 2372 items

Hygiene

Total: 325 items

Plants and health

Allergy and us

Cosmetics

Summer care for skin with hyperpigmentation

Cosmetics

Noreva is the brand that all dermatologists know!

Health

How to choose the right micellar water

Sun

Updating sun protection products in urban environments

Plants and health

Allergy and us

Cosmetics

Summer skin care with hyperpigmentation

Cosmetics

Noreva is the brand that all dermatologists know!

Health

How to choose the right micellar water

Planet Zdorovya is one of the largest pharmacy chains in the Belarusian market.