What are the common side effects of Cefdinir 300mg. How does Cefdinir interact with other medications. What precautions should be taken when using Cefdinir 300mg. How effective is Cefdinir for treating bacterial infections.

Overview of Cefdinir: Uses and Mechanism of Action

Cefdinir is a third-generation cephalosporin antibiotic used to treat various bacterial infections. It belongs to the class of medications known as cephalosporins, which work by interfering with the cell wall synthesis of bacteria, ultimately leading to their death.

Cefdinir is commonly prescribed for infections such as:

• Bronchitis
• Sinusitis
• Pharyngitis (sore throat)
• Otitis media (middle ear infection)
• Urinary tract infections (UTIs)
• Skin infections

The typical dosage for adults is 300mg taken twice daily or 600mg taken once daily, depending on the severity and type of infection. For children, the dosage is based on weight and is usually administered as an oral suspension.

Common Side Effects of Cefdinir 300mg

While Cefdinir is generally well-tolerated, it can cause some side effects. Understanding these potential reactions can help patients better manage their treatment.

Gastrointestinal Side Effects

The most common side effects of Cefdinir involve the digestive system. These include:

• Diarrhea
• Nausea
• Vomiting
• Abdominal pain

Are these side effects severe? In most cases, these gastrointestinal side effects are mild and resolve on their own. However, if diarrhea becomes severe or persists for an extended period, it’s important to contact your healthcare provider.

Other Common Side Effects

Patients taking Cefdinir 300mg may also experience:

• Headache
• Dizziness
• Fatigue
• Vaginal yeast infections (in females)

Can these side effects be managed? Most of these side effects are mild and can be managed with over-the-counter remedies or by adjusting the timing of medication intake. For instance, taking Cefdinir with food may help reduce nausea.

Serious Side Effects and Allergic Reactions

While rare, some patients may experience more severe side effects when taking Cefdinir 300mg. It’s crucial to be aware of these potential reactions and seek immediate medical attention if they occur.

Allergic Reactions

Severe allergic reactions to Cefdinir, although uncommon, can be life-threatening. Symptoms of an allergic reaction may include:

• Rash or hives
• Itching
• Swelling of the face, lips, tongue, or throat
• Difficulty breathing or swallowing
• Severe dizziness

How quickly can an allergic reaction occur? Allergic reactions can develop rapidly, sometimes within minutes of taking the medication. If you experience any signs of an allergic reaction, seek emergency medical care immediately.

Stevens-Johnson Syndrome

In rare cases, Cefdinir may cause Stevens-Johnson Syndrome (SJS), a severe skin reaction. Symptoms of SJS include:

• Widespread skin rash
• Blistering and peeling of the skin
• Fever
• Flu-like symptoms

Is Stevens-Johnson Syndrome a medical emergency? Yes, SJS is a serious condition that requires immediate medical attention. If you notice any symptoms resembling SJS, stop taking Cefdinir and contact your healthcare provider or seek emergency care right away.

Cefdinir and Clostridium difficile (C. diff) Infections

One of the more serious potential side effects of Cefdinir and other antibiotics is the development of Clostridium difficile (C. diff) infections. C. diff is a type of bacteria that can cause severe diarrhea and other intestinal problems.

Symptoms of C. diff Infection

The symptoms of a C. diff infection may include:

• Watery diarrhea (at least three times a day for two or more days)
• Fever
• Loss of appetite
• Nausea
• Abdominal pain and tenderness

How long after taking Cefdinir can C. diff infection occur? C. diff infections can occur during antibiotic treatment or even weeks to months after stopping the antibiotic. If you develop persistent diarrhea, especially if it’s accompanied by fever or severe abdominal pain, contact your healthcare provider promptly.

Drug Interactions with Cefdinir

Cefdinir can interact with various medications, potentially altering its effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all medications you’re taking, including over-the-counter drugs and supplements.

Major Drug Interactions

According to the drug interaction checker, there are 3 major drug interactions with Cefdinir. These include:

1. Probenecid: This medication can increase the blood levels of Cefdinir, potentially increasing the risk of side effects.
2. Live bacterial vaccines: Cefdinir may decrease the effectiveness of live bacterial vaccines.
3. Warfarin: Cefdinir may increase the anticoagulant effect of warfarin, potentially increasing the risk of bleeding.

Should you stop taking these medications if prescribed Cefdinir? Never stop taking any prescribed medication without consulting your healthcare provider first. They may need to adjust dosages or monitor you more closely if these combinations are necessary.

Moderate Drug Interactions

There are 42 moderate drug interactions with Cefdinir. Some common medications that may interact with Cefdinir include:

• Oral contraceptives
• Antacids containing aluminum or magnesium
• Iron supplements
• Certain diabetes medications

How can these interactions be managed? Your healthcare provider may recommend taking Cefdinir at a different time than these medications or may need to adjust dosages. Always follow your healthcare provider’s instructions regarding medication timing and dosage.

Special Precautions and Warnings for Cefdinir Use

While Cefdinir is generally safe for most patients, there are certain groups who should use this medication with caution or may need special monitoring.

Kidney Disease

Patients with kidney disease may need dosage adjustments when taking Cefdinir. The medication is primarily eliminated through the kidneys, and impaired kidney function can lead to higher blood levels of the drug.

How is Cefdinir dosage adjusted for kidney disease? Your healthcare provider will likely calculate your kidney function using a blood test and adjust the Cefdinir dosage accordingly. This may involve reducing the dose or increasing the time between doses.

Phenylketonuria (PKU)

The oral suspension form of Cefdinir contains phenylalanine, which can be problematic for individuals with phenylketonuria (PKU).

Are there alternative formulations for patients with PKU? If you have PKU, inform your healthcare provider. They may prescribe the capsule form of Cefdinir or an alternative antibiotic that doesn’t contain phenylalanine.

Pregnancy and Breastfeeding

Cefdinir is generally considered safe during pregnancy and breastfeeding, but it should be used only when clearly needed.

Does Cefdinir pass into breast milk? Small amounts of Cefdinir can pass into breast milk. While this is not expected to harm most infants, it’s important to monitor breastfed infants for potential side effects such as diarrhea or yeast infections.

Managing and Minimizing Cefdinir Side Effects

While side effects from Cefdinir can be uncomfortable, there are several strategies to manage and minimize them.

Gastrointestinal Side Effects

To manage diarrhea, nausea, and other gastrointestinal side effects:

• Take Cefdinir with food to reduce stomach upset
• Stay well-hydrated to replace fluids lost due to diarrhea
• Consider probiotic supplements to help maintain a healthy gut flora
• Avoid dairy products within 2 hours of taking Cefdinir, as they can interfere with absorption

How long do gastrointestinal side effects typically last? In most cases, these side effects subside within a few days as your body adjusts to the medication. If they persist or worsen, consult your healthcare provider.

Yeast Infections

To prevent or manage yeast infections:

• Wear breathable, cotton underwear
• Avoid tight-fitting clothing
• Consider taking a probiotic supplement
• If symptoms of a yeast infection develop, consult your healthcare provider for appropriate treatment

Can over-the-counter treatments be used for yeast infections while taking Cefdinir? While over-the-counter antifungal treatments are available, it’s best to consult your healthcare provider before using them, as they may interact with Cefdinir or mask other symptoms.

Effectiveness of Cefdinir in Treating Bacterial Infections

Cefdinir has proven to be effective against a wide range of bacterial infections. Its broad-spectrum activity makes it a valuable tool in the treatment of respiratory, skin, and urinary tract infections.

Respiratory Infections

Cefdinir is particularly effective in treating respiratory infections such as:

• Acute exacerbations of chronic bronchitis
• Community-acquired pneumonia
• Acute bacterial sinusitis
• Pharyngitis/tonsillitis

How quickly does Cefdinir work for respiratory infections? While you may start feeling better within a few days, it’s crucial to complete the entire course of antibiotics as prescribed, typically 10-14 days for most respiratory infections.

Skin Infections

Cefdinir is also effective against various skin and soft tissue infections, including:

• Cellulitis
• Impetigo
• Wound infections

What is the typical duration of treatment for skin infections? The duration of treatment can vary depending on the severity and type of infection, but it typically ranges from 7 to 14 days.

Urinary Tract Infections (UTIs)

Cefdinir is effective in treating uncomplicated urinary tract infections caused by susceptible bacteria.

How long does it take for Cefdinir to clear a UTI? While symptoms may improve within a few days, it’s important to complete the entire course of antibiotics, which is typically 7-14 days for UTIs.

In conclusion, Cefdinir 300mg is a potent antibiotic with a broad spectrum of activity against various bacterial infections. While it can cause side effects, most are mild and manageable. By understanding potential side effects, drug interactions, and proper usage guidelines, patients can maximize the benefits of this medication while minimizing risks. Always consult with your healthcare provider for personalized advice and report any unusual or severe side effects promptly.

Cefdinir Interactions Checker – Drugs.com

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There are 45 drugs known to interact with
cefdinir, along with
7 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
3 are major, and 42 are moderate.

Does cefdinir interact with my other drugs?

Enter other medications to view a detailed report.

• View all 45 medications that may interact with cefdinir
• View cefdinir alcohol/food interactions (1)
• View cefdinir disease interactions (7)

Most frequently checked interactions

View interaction reports for cefdinir and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• Aspirin Low Strength (aspirin)
• Augmentin (amoxicillin / clavulanate)
• Benadryl (diphenhydramine)
• Claritin (loratadine)
• CoQ10 (ubiquinone)
• Cymbalta (duloxetine)
• Eliquis (apixaban)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Flexeril (cyclobenzaprine)
• Flonase (fluticasone nasal)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• Metoprolol Tartrate (metoprolol)
• MiraLAX (polyethylene glycol 3350)
• Mucinex (guaifenesin)
• Norco (acetaminophen / hydrocodone)
• ProAir HFA (albuterol)
• Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
• Protonix (pantoprazole)
• Singulair (montelukast)
• Symbicort (budesonide / formoterol)
• Synthroid (levothyroxine)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D2 (ergocalciferol)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zofran (ondansetron)
• Zyrtec (cetirizine)

Cefdinir alcohol/food interactions

There is 1 alcohol/food interaction with cefdinir.

Cefdinir disease interactions

There are 7 disease interactions with cefdinir which include:

• colitis
• renal dysfunction
• diabetes
• nitroprusside tests
• dialysis
• liver disease
• seizure disorders

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• Compare alternatives
• Pricing & coupons
• Reviews (382)
• Drug images
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Support group
• Drug class: third generation cephalosporins
• Breastfeeding
• En español

Related treatment guides

• Bacterial Infection
• Otitis Media
• Pneumonia
• Bronchitis

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Cefdinir side effects and how to avoid them

Diarrhea, yeast infection, and headache are common cefdinir side effects, but this antibiotic can also cause a rash and C.Diff

Common cefdinir side effects | Diarrhea | Yeast infection | Serious side effects | Rash | C.Diff | Side effects in seniors | How long do side effects last? | Warnings | Interactions | How to avoid side effects

Cefdinir (brand name: Omnicef) is a third-generation cephalosporin antibiotic used to treat certain bacterial infections such as bronchitis, sinusitis, pharyngitis (sore throat), and urinary tract infections (UTIs). It works by killing harmful bacteria throughout the body. It comes in both capsule and oral suspension form and is usually taken for up to 10 days, depending on the type of infection being treated.

Common side effects include diarrhea, vomiting, and headache. Serious adverse reactions are less common and include severe allergic reactions, Steven-Johnson’s syndrome, and Clostridium difficile (C. difficile) infections. Drug interactions are also possible when taking cefdinir. Be sure to tell your healthcare provider if you have any medical conditions or are taking any medications before taking cefdinir.

RELATED: Learn more about cefdinir |Get cefdinir discounts

Common side effects of cefdinir

The most common side effects of cefdinir include:

• Diarrhea 
• Yeast infection (candidiasis) 
• Nausea and/or vomiting
• Headache
• Abdominal pain
• Inflammation of the vagina (vaginitis)
• Rash 
• Indigestion/Flatulence

Some clinically significant laboratory changes that might be seen include:

• Increased white blood cells in urine 
• Increased levels of protein in the urine (proteinuria)
• Microscopic amounts of blood in the urine (microhematuria) 
• Increased blood sugar (glucose)
• High levels of eosinophils (eosinophilia), which are a special type of white blood cells
• Elevated liver enzymes i. e. alanine aminotransferase (ALT) or aspartate aminotransferase (AST)

Diarrhea

In the same adult clinical trial mentioned above, 15% of adults and adolescents experienced diarrhea. 

The pediatric clinical trial showed 8% of children being treated with cefdinir experienced diarrhea and 0.8% experienced abdominal pain. The rates of diarrhea were highest in patients younger than 2 years old (17%).

If diarrhea is severe during treatment with cefdinir, consult your healthcare provider to rule out a C. difficile infection.

Yeast infection

Cefdinir destroys harmful bacteria in the body, but can also destroy the good bacteria. This may result in oral thrush and vaginal yeast infections during treatment with cefdinir. 

A clinical trial of 5,093 adults and adolescents taking 600 mg of cefdinir per day found that 4% of women experienced a vaginal yeast infection during treatment. In the same group, there was a 0.2% occurrence of yeast infections unrelated to the vagina.

Another trial of 2,289 pediatric patients showed vaginal yeast infections in 0.3% of girls being treated with cefdinir and fungal skin infections in 0.9% of all children.

RELATED: How to prevent yeast infections from antibiotics

Serious side effects of cefdinir

Serious side effects while taking cefdinir are rare but possible. These side effects include:

• Severe allergic reaction (anaphylaxis)
• Stevens-Johnson syndrome: flu-like symptoms accompanied by painful rash and blisters
• Toxic epidermal necrolysis: a rare condition causing skin peeling and blistering
• Exfoliative dermatitis: redness and peeling of large areas of skin
• C. difficile infection causing severe diarrhea and colitis
• Low neutrophils (neutropenia)
• Low platelet count (thrombocytopenia)
• Hemolytic anemia
• Aplastic anemia
• A severe immune reaction (serum sickness)
• Renal toxicity
• Liver toxicity

Cefdinir rash

Several side effects of cefdinir may be accompanied by a rash, including an allergic reaction, Stevens-Johnson syndrome, toxic epidermal necrolysis, and exfoliative dermatitis.

Clinical trials reported rash at an incidence of 0.9% in adults and adolescents being treated with cefdinir. Rash occurred in 3% of children taking this medication, although the majority of these occurrences were in children younger than 2 years old.

Seek emergency medical attention right away if rash-like symptoms are accompanied by wheezing, tightness in the chest or throat, or trouble breathing. This could be a sign of a potentially dangerous allergic reaction.

Clostridium difficile-associated diarrhea

Treatment with Cefdinir can destroy some of the bacteria in the gut. This allows other organisms such as C. difficile to grow out of control. C. difficile produces toxins that may cause swelling/inflammation in the lining of the large intestine. This inflammation is called pseudomembranous colitis. This can cause diarrhea ranging in severity from mild diarrhea to fatal colitis. Symptoms include:

• Frequent watery diarrhea that is sometimes bloody
• Pain and tenderness in the stomach
• Cramping
• Nausea
• Fever
• Loss of appetite

RELATED: Antibiotics that cause C. Difficile

Cefdinir side effects in elderly

People with multiple comorbidities may have an increased risk of side effects when treated with antibiotics, and older adults have more underlying health conditions than younger patients. However, clinical trials found cefdinir to be a safe drug for older patients, with a lower adverse reaction rate compared to young adults.

How long do cefdinir side effects last?

Most cefdinir side effects will subside during or shortly after treatment, although some may require medical attention. Yeast infections, oral thrush, and C. difficile are some examples of side effects that may need to be treated with other medications.

Severe allergic reactions require immediate medical attention. Signs of a severe allergic reaction include:

• Rash or hives
• Swollen or blistered areas of skin
• Red, peeling skin
• Wheezing
• Chest tightness
• Swelling of the mouth, face, lips, throat, or tongue
• Difficulty breathing

Cefdinir contraindications and warnings

Cefdinir may not be appropriate for everyone. Discuss any medical conditions with your healthcare provider before starting treatment, especially if you have ever had:

• Kidney disease or a history of dialysis
• Allergies to other antibiotics, especially cephalosporins and penicillins
• Colitis
• Diabetes (oral suspension contains sucralose)
• Seizure disorders

Kidney disease

Use caution in patients with a creatinine clearance of <30mL/min. Dosage should be reduced in these patients with kidney problems. There is evidence that cephalosporin antibiotics may cause seizures in patients with renal impairment whose dosage was not reduced.

Colitis

Use caution in patients with a history of colitis. Clostridium difficile-associated diarrhea may be more severe in these patients if it occurs. 

Diabetes

Cefdinir can increase blood sugar on its own. The liquid form of cefdinir also contains sugar, which may alter blood glucose levels. Diabetic patients should avoid using cefdinir suspension to ensure that blood sugar levels aren’t altered during treatment. Careful glucose monitoring is required when Cefdinir must be used.

Withdrawal

Cefdinir does not cause dependency or withdrawal symptoms. However, like all antibiotics, if a patient does not finish the full course of antibiotics, an infection may persist or recur.

Overdose

Overdose on any medication is possible, including cefdinir. Signs of overdose include:

• Nausea
• Vomiting
• Stomach pain
• Diarrhea
• Seizures

If an overdose is suspected, seek emergency medical attention or call the Poison Control Center immediately. 

Children

Cefdinir is FDA-approved to treat certain bacterial infections in children as young as 2 months. It may treat bacterial ear infections (otitis media), sinusitis, pharyngitis, tonsillitis, pneumonia, and bacterial skin infections.

Pregnancy

According to the FDA, cefdinir is a pregnancy category B medication. There is no human data available to measure risk, but animal data shows no known risks or complications of taking cefdinir while pregnant. If you’re pregnant, be sure to talk to your healthcare provider about the risks before taking this medication.

Breastfeeding

Cefdinir may be taken while breastfeeding. There is no human data available to determine the risk to the infant, however, no risk is expected based on data from other cephalosporin antibiotics. It is not yet known if cefdinir affects breast milk production.

Cefdinir interactions

There are several drugs and supplements that may interact with cefdinir, according to the FDA. Be sure to tell your healthcare provider what medications, vitamins, and supplements you’re taking before beginning treatment.

• Antacids, magnesium, and iron supplements: Some antacids or supplements containing iron or magnesium may interfere with cefdinir absorption. Take 2 hours before or after Cefdinir. Patients taking iron may also experience a reddish stool discoloration (not related to bleeding). The reddish color is due to the formation of a complex between cefdinir and iron in the gut.
• Probenecid: Taking probenecid, a uric acid reducer that treats gout, may increase levels of cefdinir in the body.
• Hormonal contraceptives: Cefdinir may decrease the efficacy of hormonal birth control; use another form of birth control while taking cefdinir.
• Tetracyclines: Taking tetracyclines with cefdinir may alter the way cefdinir works inside the body.

How to avoid cefdinir side effects

Cefdinir may cause side effects, but there are ways to reduce the risk for these undesired effects. Some ways to avoid side effects while taking cefdinir include:

• Take cefdinir as directed. Follow the medical advice of your healthcare provider and instructions given by your pharmacist. Be sure to shake your liquid cefdinir before use and measure using an appropriate dosing syringe.
• Take cefdinir with or without food. You don’t have to take cefdinir with food, however, taking it with food may decrease stomach discomfort.
• Don’t skip doses. If you forget a dose of cefdinir, take the missed dose as soon as possible. If it’s almost time for your next dose, skip the missed dose. Never double up on doses, as this may cause unwanted side effects.
• Avoid antacids, magnesium, and iron supplements for at least two hours before and after taking cefdinir. Some antacids and supplements interfere with the absorption of cefdinir. Avoid taking antacids or supplements containing magnesium or iron within two hours of taking cefdinir to prevent these interactions.
• Tell your provider about all medical conditions. Cefdinir may not be the best medication for patients with certain medical conditions. Avoid taking cefdinir if you’ve had an allergic reaction to cephalosporin antibiotics in the past.
• Tell your provider what other medications you are taking. Drug interactions while taking cefdinir are possible. Tell your healthcare provider of any prescription drugs, over-the-counter medications, supplements, and herbal products before beginning treatment.
• Don’t stop taking cefdinir before you’ve finished treatment unless directed to do so by a healthcare professional. It’s important to finish your entire treatment, even if your symptoms improve. Discontinuing the medication early may cause repeat infection or antibiotic resistance.
• Store cefdinir properly. Keep this medication at room temperature away from moisture and heat and out of reach of children. Discard your unused cefdinir after treatment.

Resources

• Omnicef drug information, Federal Drug Administration (FDA)
• Cefdinir adverse reactions, Epocrates
• Cefdinir contraindications, Epocrates
• Cefdinir drug label info, DailyMed

Rinicef ​​300mg/ Rinicef ​​300mg

Trade name: Rinicef

International Nonproprietary Name: Cefdinir/Cefdinir

Presentation: capsules 300 mg.

Description: hard gelatin capsules, black opaque cap and gray opaque base.

Composition:

1 capsule contains:

active substance : cefdinir – 300.00 mg;

Pharmacotherapeutic group

Antibacterial agents for systemic use. Third generation cephalosporins. ATX code: J01DD15

Pharmacological properties.

Pharmacodynamics

The active substance cefdinir is a semi-synthetic broad-spectrum cephalosporin antibiotic of the third generation for oral administration. Like other antibiotics of the cephalosporin group, cefdinir has a bactericidal effect against susceptible microorganisms due to the inhibition of the synthesis of peptidoglycan of the bacterial cell wall by disrupting the final stage of transamination necessary for the formation of cross-links. Cefdinir is resistant to many, but not all, beta-lactamases produced by Gram-positive and Gram-negative bacteria. Due to this, many microorganisms resistant to penicillins and some cephalosporins are sensitive to cefdinir. The spectrum of action of cefdinir includes:

Aerobic Gram-positive microorganisms

Staphylococcus aureus (including beta-lactamase producing strains)

Staphylococcus pneumoniae
(only strains sensitive to penicillin)

Staphylococcus pyogenes

Aerobic gram-negative microorganisms

Haemophilus influenzae (including beta-lactamase producing strains)

Haemophilus parainfluenzae
(including beta-lactamase producing strains)

Moraxella catarrhalis (including beta-lactamase producing strains)

The following data was obtained in vitro , but their clinical significance is unknown.

Minimum inhibitory concentration (MIC) of cefdinir in in vitro
is 1 μg / ml or less in relation to (≥ 90%) strains of the following microorganisms; however, the safety and efficacy of cefdinir in the treatment of infections caused by the following microorganisms has not been demonstrated in clinical studies.

Aerobic gram-positive microorganisms

Staphylococcus epidermidis

Streptococcus agalactiae

Streptococcus viridans group

Aerobic gram-negative microorganisms

Citrobacter diversus

Escherichia coli

Klebsiela pneumoniae

Proteus mirabilis

Cefdinir is inactive against strains Pseudomonas, Enterobacter, Enterococcus and methicillin-resistant strains of staphylococci.

Method of administration and dosage

Recommended dosages and duration of treatment for infections in adults and adolescents are described in the table below. The total daily dose for the treatment of all infections is 600 mg. Dosing the drug once a day for 10 days is as effective as taking it twice a day. Once-daily dosing has not been studied for the treatment of pneumonia and skin infections, so Rinicef ​​should be taken twice daily in these cases. The capsules can be taken with or without food.

For the treatment of children (6 months – 12 years), cefdinir is used in the form of a suspension.

Adults and adolescents (ages 13 and over)

Elderly patients: does not require a change in dosing regimen, unless there is a significant impairment of renal function (CC < 30 ml / min). If CC < 30 ml / min, the drug should be taken at a dose of 300 mg once a day.

Patients with renal insufficiency

For patients with CC < 30 ml/min, cefdinir should be given at a dose of 300 mg once daily.

Hemodialysis patients

Hemodialysis promotes the elimination of cefdinir from the body. For patients on permanent hemodialysis, the recommended starting dose is 300 mg or 7 mg/kg every other day. At the end of each hemodialysis session, 300 mg (or 7 mg/kg) of cefdinir is given. Subsequent doses (300 mg or 7 mg/kg) are then given every other day.

If you miss the next dose of the drug, you should take it as soon as you remember. If this missed dose occurs at the time of the next dose, skip the missed dose and follow the previous dosing regimen, do not double the dose.

Side effect

Cefdinir is well tolerated, the identified adverse reactions were mild in nature and resolved spontaneously after discontinuation. Most withdrawals were associated with gastrointestinal disturbances, mainly manifested by diarrhea or nausea. In rare cases, the withdrawal of the drug was due to the development of a rash while taking cefdinir.

Adverse reactions are classified according to the frequency of occurrence: very often (? 1/10), often (from ? 1/100 to < 1/10), infrequently (from ? 1/1,000 to < 1/100), rarely (? 1/10,000, <1/1000), very rarely (< 1/10,000), and the frequency is unknown (the frequency cannot be established according to the available data).

Very common: diarrhea, rash, nausea.

Often: skin candidiasis, abdominal pain, leukopenia, candidal vaginitis, vaginitis, stool changes, dyspepsia, hyperkinesis, macolopapular rash, nausea, increased AST.

Adverse reactions specific to cephalosporins

Allergic reactions, anaphylaxis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, renal dysfunction, toxic nephropathy, liver dysfunction including cholestasis, aplastic anemia, hemolytic anemia, hemorrhagic disorders, false positive urine glucose test, neutropenia, pancytopenia and agranulocytosis. Pseudomembranous colitis can develop both during and after the end of the antibiotic prescription.

The use of some cephalosporins was accompanied by the development of seizures, especially in patients with impaired renal function, who were not dose recalculated. If convulsions develop during therapy, the antibiotic should be discontinued. If clinically necessary, anticonvulsant therapy may be prescribed.

According to the results of post-registration experience of use, the following adverse reactions were identified: shock, anaphylaxis (in rare cases with a fatal outcome), edema of the subglottic space and face, feeling of suffocation, serum-like syndrome, conjunctivitis, stomatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, erythema nodosum, acute hepatitis, cholestatic syndrome, lightning nasal hepatitis, liver failure, jaundice, amylase elevation, acute enterocolitis, hemorrhagic diarrhea, hemorrhagic colitis, melena, pseudomembranous colitis, pancytopenia, granulocytopenia, leukopenia, thrombocytopenia, idiopathic thrombocytopenic purpura, hemolytic anemia, acute respiratory failure, asthma attack, drug-induced pneumonia, eosinophilic pneumonia, idiopathic interstitial pneumonia, fever, acute renal failure, nephropathy, bleeding tendency, bleeding disorder, generalized thrombohemorrhagic syndrome, upper gastrointestinal bleeding, peptic ulcer, intestinal obstruction, unconsciousness, allergic vasculitis, possible cefdinir-diclofenac interaction, heart failure, chest pain, myocardial infarction, rhabdomyolysis, involuntary movements, hypertension.

In the event of the listed adverse reactions, as well as a reaction not indicated in the instructions for use, you should consult a doctor.

Contraindications

Rinicef ​​is contraindicated in patients with a history of allergy to the cephalosporin class of antibiotics and hypersensitivity to excipients in the composition of the drug.

Overdose

Data on cefdinir overdose in humans are not available.

In acute toxicity studies in rodents, a single oral dose of cefdinir at a dose of 5600 mg/kg did not lead to the development of adverse reactions. The following signs and symptoms of overdose have been observed with other beta-lactam antibiotics: nausea, vomiting, stomach discomfort, diarrhea, and convulsions.

During hemodialysis, cefdinir is removed from the body, which can be useful in case of serious toxic reactions caused by overdose, especially if the patient has impaired renal function.

Precautions

Before starting therapy with Rinicef, it is necessary to exclude the presence of a history of hypersensitivity reactions to penicillins, cephalosporins or other drugs.

In case of suspicion or confirmation of the development of Clostridium difficile -associated diarrhea, antibiotic therapy should be discontinued if it does not work on Clostridium difficile . Based on the clinical condition, the patient may be indicated for fluid replacement, administration of electrolyte and amino acid solutions, antibiotic therapy. Clostridium difficile

Rinicef, like other broad-spectrum antimicrobials (antibiotics), should be used with caution in patients with a history of colitis.

In patients with transient or persistent renal insufficiency (CC <30 ml/min), the daily dose of Rinicef ​​should be reduced, since administration at the recommended doses can lead to a significant increase in plasma concentrations and the half-life of cefdinir.

The administration of cephalosporins can sometimes lead to a positive Coombs test result.

Use during pregnancy and lactation.

Pregnancy and childbirth

Experimental reproduction studies have shown the absence of any teratogenic effect.

Data on the results of the use of cefdinir in pregnant women are not available. Cefdinir should only be used during pregnancy if there is a justified clinical need.

Data on the effect of the appointment of cefdinir on childbirth are not available.

Lactation

When prescribing cefdinir at a dose of 600 mg, it is not detected in breast milk in nursing mothers. Cefdinir is prescribed during lactation only after a careful assessment of the benefit / risk ratio for mother and child.

Influence on the ability to drive vehicles and work with mechanisms.

Rincef does not affect the ability to drive vehicles and work with mechanisms.

Interaction with other drugs

Co-administration of cefdinir and an antacid results in a decrease in the rate (C _max ) and extent (AUC) of cefdinir absorption by approximately 40%. If antacids are required during treatment with Rinicef, Rinicef ​​should be taken at least 2 hours before or 2 hours after taking the antacid.

As with other beta-lactam antibiotics, probenicide interferes with renal excretion of cefdinir when administered concomitantly, resulting in an approximately two-fold increase in AUC, a 54% increase in maximum cefdinir plasma concentration, and a prolongation of the half-life t _1/2 by 50%.

The simultaneous administration of cefdinir with iron-containing drugs containing 60 mg of elemental iron (as FeSO ₄ ), or vitamin drugs containing 10 mg of iron, reduces the absorption of cefdinir by 80% and 31%, respectively. If a patient requires iron medications during cefdinir therapy, Rinicef ​​should be taken at least 2 hours before or after taking iron medications.

There have been reports of reddish-colored stools in patients taking cefdinir. In many cases, iron-fortified foods were taken concomitantly by these patients. The reddish coloration may be due to the formation in the gastrointestinal tract of a non-absorbable complex of cefdinir or its degradation products and iron.

During treatment with cefdinir, false-positive results for urinary ketones may occur with nitroprusside, but not with nitroferricyanide. False-positive results may also be noted when determining glucose in the urine using Benedict’s solution or Fehling’s reagent (it is recommended to determine glycosuria only by the enzyme method). The use of cephalosporins can sometimes lead to a positive Coombs test result.

Storage conditions and shelf life

At a temperature not higher than 25°C.

Keep out of the reach of children!

Shelf life 3 years. Do not use after the expiry date stated on the packaging.

Holiday conditions

By prescription.

Packaging

10 capsules in a blister pack made of PVC film and flexible packaging based on aluminum foil.

1 or 2 blister packs, together with the leaflet, are placed in a cardboard pack.

Manufacturer information

Foreign production and trade unitary enterprise “Reb-Pharma”, 223216, Republic of Belarus, Minsk region, Chervensky district, settlement. Smilovichi, st. Sadovaya, 1, tel./fax: (+375) 17 240 26 35, e-mail: [email protected], http://www.rebpharma.by.

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