Cipro Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Quinolone antibiotics (including ciprofloxacin) may cause serious and possibly permanent tendon damage (such as tendonitis, tendon rupture), nerve problems in the arms and legs (peripheral neuropathy), and nervous system problems. Get medical help right away if you have any of the following symptoms: pain/numbness/burning/tingling/weakness in your arms/hands/legs/feet, changes in how you sense touch/pain/temperature/vibration/body position, severe/lasting headache, vision changes, shaking (tremors), seizures, mental/mood changes (such as agitation, anxiety, confusion, hallucinations, depression, rare thoughts of suicide).

Tendon damage may occur during or after treatment with this medication. Stop exercising, rest, and get medical help right away if you develop joint/muscle/tendon pain or swelling. Your risk for tendon problems is greater if you are over 60 years of age, if you are taking corticosteroids (such as prednisone), or if you have a kidney, heart, or lung transplant.

This medication may make a certain muscle condition (myasthenia gravis) worse. Tell your doctor right away if you have new or worsening muscle weakness (such as drooping eyelids, unsteady walk) or trouble breathing.

Discuss the risks and benefits with your doctor before using this medication.

Warnings:

Quinolone antibiotics (including ciprofloxacin) may cause serious and possibly permanent tendon damage (such as tendonitis, tendon rupture), nerve problems in the arms and legs (peripheral neuropathy), and nervous system problems. Get medical help right away if you have any of the following symptoms: pain/numbness/burning/tingling/weakness in your arms/hands/legs/feet, changes in how you sense touch/pain/temperature/vibration/body position, severe/lasting headache, vision changes, shaking (tremors), seizures, mental/mood changes (such as agitation, anxiety, confusion, hallucinations, depression, rare thoughts of suicide).

Tendon damage may occur during or after treatment with this medication. Stop exercising, rest, and get medical help right away if you develop joint/muscle/tendon pain or swelling. Your risk for tendon problems is greater if you are over 60 years of age, if you are taking corticosteroids (such as prednisone), or if you have a kidney, heart, or lung transplant.

This medication may make a certain muscle condition (myasthenia gravis) worse. Tell your doctor right away if you have new or worsening muscle weakness (such as drooping eyelids, unsteady walk) or trouble breathing.

Discuss the risks and benefits with your doctor before using this medication.

… Show More

Uses

This medication is used to treat a variety of bacterial infections. Ciprofloxacin belongs to a class of drugs called quinolone antibiotics. It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for virus infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

How to use Cipro

Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking ciprofloxacin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually twice a day in the morning and evening.

The tablet may have a bitter taste if you chew or crush it before taking it. Do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. The manufacturer recommends swallowing the whole or split tablet without crushing or chewing.

The dosage and length of treatment is based on your medical condition and response to treatment. Drink plenty of fluids while taking this medication unless your doctor tells you otherwise.

Take this medication at least 2 hours before or 6 hours after taking other products that may bind to it, decreasing its effectiveness. Ask your pharmacist about the other products you take. Some examples include: quinapril, sevelamer, sucralfate, vitamins/minerals (including iron and zinc supplements), and products containing magnesium, aluminum, or calcium (such as antacids, didanosine solution, calcium supplements).

Calcium-rich foods, including dairy products (such as milk, yogurt) or calcium-enriched juice, can also decrease the effect of this medication. Take this medication at least 2 hours before or 6 hours after eating calcium-rich foods, unless you are eating these foods as part of a larger meal that contains other (non-calcium-rich) foods. These other foods decrease the calcium binding effect.

Ask your doctor or pharmacist about safely using nutritional supplements/replacements with this medication.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

Side Effects

See also Warning section.

Nausea, diarrhea, dizziness, lightheadedness, headache, and trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: unusual bruising/bleeding, signs of a new infection (such as sore throat that doesn’t go away, fever), signs of kidney problems (such as change in the amount of urine, red/pink urine), signs of liver problems (such as nausea/vomiting that doesn’t stop, unusual tiredness, stomach/abdominal pain, yellowing eyes/skin, dark urine).

Get medical help right away if you have any very serious side effects, including: severe dizziness, fainting, fast/irregular heartbeat, signs of a tear/break in the main blood vessel called the aorta (such as sudden/severe pain in the stomach/chest/back, shortness of breath).

This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn’t stop, abdominal or stomach pain/cramping, blood/mucus in your stool.

If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking ciprofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics such as norfloxacin, gemifloxacin, levofloxacin, moxifloxacin, or ofloxacin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, heart problems (such as recent heart attack), joint/tendon problems (such as tendonitis, bursitis), kidney disease, liver disease, mental/mood disorders (such as depression), myasthenia gravis, nerve problems (such as peripheral neuropathy), seizures, conditions that increase your risk of seizures (such as brain/head injury, brain tumors, cerebral atherosclerosis), blood vessel problems (such as aneurysm or blockage of the aorta or other blood vessels, hardening of the arteries), high blood pressure, certain genetic conditions (Marfan syndrome, Ehlers-Danlos syndrome).

Ciprofloxacin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using ciprofloxacin, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using ciprofloxacin safely.

This medication may rarely cause serious changes in blood sugar, especially if you have diabetes. Check your blood sugar regularly as directed and share the results with your doctor. Watch for symptoms of high blood sugar such as increased thirst/urination. Ciprofloxacin may increase the blood-sugar-lowering effects of the medication glyburide. Also watch for symptoms of low blood sugar such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don’t have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or by drinking fruit juice or non- diet soda. Tell your doctor right away about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Your doctor may need to switch you to another antibiotic or adjust your diabetes medications if any reaction occurs.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Ciprofloxacin may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Tell your health care professional that you are using ciprofloxacin before having any immunizations/vaccinations.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children may be more sensitive to the side effects of this drug, especially joint/tendon problems.

Older adults may be at greater risk for tendon problems (especially if they are also taking corticosteroids such as prednisone or hydrocortisone), QT prolongation, and a sudden tear/break in the main blood vessel (aorta).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also How to Use and Precautions sections.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: “blood thinners” (such as acenocoumarol, warfarin), strontium.

Many drugs besides ciprofloxacin may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, quinidine, procainamide, sotalol, among others.

This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include duloxetine, fezolinetant, pirfenidone, tasimelteon, tizanidine, among others.

Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas), eating large amounts of chocolate, or taking over-the-counter products that contain caffeine. This drug may increase and/or prolong the effects of caffeine.

Does Cipro interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

Lab and/or medical tests (such as kidney function, blood counts, cultures) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Do not change brands of this medication without checking with your doctor or pharmacist. Not all brands have the same effects.

If you miss a dose, take it as soon as you remember. If it is less than 6 hours before the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Cipro 250 mg tablet

Color: slightly yellowShape: roundImprint: BAYER BAYER CIP 250

This medicine is a slightly yellow, round, film-coated, tablet imprinted with “BAYER BAYER” and “CIP 250”.

Cipro 500 mg tablet

Color: slightly yellowShape: oblongImprint: BAYER CIP 500

This medicine is a slightly yellow, round, film-coated, tablet imprinted with “BAYER BAYER” and “CIP 250”.

Cipro 500 mg tablet

Color: slightly yellowShape: oblongImprint: CIPRO 500

This medicine is a slightly yellow, round, film-coated, tablet imprinted with “BAYER BAYER” and “CIP 250”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Cipro 250mg Tablet: View Uses, Side Effects, Price and Substitutes

Product introduction

Cipro 250mg Tablet is an antibiotic, used in the treatment of bacterial infections. It is also used in treating infections of the urinary tract, nose, throat, skin and soft tissues and lungs (pneumonia). It cures the infection by killing and stopping the growth of the infectious microorganisms.

Cipro 250mg Tablet should be used in the dose and duration as advised by your doctor. It may be taken with or without food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned.

You may experience nausea as a side effect of this medicine. This is usually temporary and resolves on its own, but please consult your doctor if it bothers you or persists for a longer duration. Diarrhea may also occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.

You should not take this medicine if you are allergic to any of its ingredients. Rarely, some people may have a severe allergic reaction which needs urgent medical attention. Signs of this include rash, swelling of the lips, tongue, or face, shortness of breath, or breathing problems. Special care should be taken in people with kidney problems while taking this medicine.

Uses of Cipro Tablet

• Treatment of Bacterial infections

Benefits of Cipro Tablet

In Treatment of Bacterial infections

Cipro 250mg Tablet is a versatile antibiotic medicine that can be used to treat many different infections caused by bacteria. These include infections of the urinary tract, nose, throat, skin, and soft tissues and lungs (pneumonia). It kills and stops further growth of the bacteria causing the infection.

This medicine usually makes you feel better quite quickly. However, you should continue taking it as long as it is prescribed even when you feel better, to make sure that all bacteria are killed and do not become resistant.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Cipro

• Headache
• Dizziness
• Gastrointestinal disorder
• Joint pain
• Urticaria

How to use Cipro Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cipro 250mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Avoid Cipro 250mg Tablet with caffeine and chocolate as well as food containing caffeine and chocolate such as tea leaves, cocoa beans.

How Cipro Tablet works

Cipro 250mg Tablet is an antibiotic. It works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.

Safety advice

Alcohol

SAFE

Consuming alcohol with Cipro 250mg Tablet does not cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

Cipro 250mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Cipro 250mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Baby should be closely monitored for development of fever, loss of appetite and diarrhea. In case, any of the above happens please inform your doctor immediately.

Driving

UNSAFE

Cipro 250mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Cipro 250mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Cipro 250mg Tablet may be needed. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Cipro 250mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Cipro 250mg Tablet may not be needed in these patients. Please consult your doctor.
Inform your doctor if you develop any signs of jaundice like yellowing of eyes and skin, itching, and clay colored stools while taking this medicine.

What if you forget to take Cipro Tablet?

If you miss a dose of Cipro 250mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Cipro 250mg Tablet

₹0.99/Tablet

Ciplox 250 Tablet

Cipla Ltd

₹2.4/tablet

142% costlier

Ciprobid 250 Tablet

Zydus Cadila

₹2.02/tablet

104% costlier

Floxip 250 Tablet

Abbott

₹1.85/tablet

87% costlier

Ciprodac 250 Tablet

Cadila Pharmaceuticals Ltd

₹2/tablet

102% costlier

Cifran 250 Tablet

Sun Pharmaceutical Industries Ltd

₹2.04/tablet

106% costlier

View all substitutes

Quick tips

• Your doctor has prescribed Cipro 250mg Tablet to cure your infection and improve symptoms.

• Do not skip any doses and finish the full course of treatment even if you feel better.

• Discontinue Cipro 250mg Tablet and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.

• Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn’t stop or if you find blood in your stools.

• Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.

• Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Fact Box

Chemical Class

Fluoroquinolone

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Quinolones/ Fluroquinolones

Interaction with drugs

Taking Cipro with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Rasagiline

Brand(s): Rasalect, Relgin, Rasipar

Life-threatening

Selegiline

Brand(s): Selgelin, Jumex, Selgin

Life-threatening

Tizanidine

Brand(s): Tizonec, Tidired, Tizakind

Life-threatening

Strontium Chloride

Brand(s): Bentoform

Life-threatening

View all interactions

Patient concerns

i have been suffering from bact, prostatitis since 7 years. symptoms come back. tried cipro, now wanna try levo with flomax.

Dr. Praveen Pushkar

Urology

It will take time to resolve

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Severe tooth pain. Taken cipro 500 mg tabs for 5 days with zerodol sp but not reduced pain. What medicines shall i take ?

Dr. Rohan Bhatt

Dental Surgery

Fo for tooth x rayMay be u have to go for rct

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Scar on face due to bacterial infections

Dr. Atul Jain

Dermatology

Pic is not clear, plz visit for proper opinion

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I am facing some problems with my face small pimples grow local pham. Gave me cipro cf wich helped me should I continue it

Sunaina Khetarpal

Dietetics/Nutrition

Hi PATIENT 1 tsp of Apple cider vinegar with lukewarm water also do cut down ur sugar levels have coconutwater everyday It would help u out have berries in your diet like blueberries strawberries

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I have a history of recurring yeast and bacterial vaginosis infections.

Dr. Sonu Balhara Ahlawat

Obstetrics and Gynaecology

Tab metrogyl 500 mg twice a day x 5 days and tab fluconazole 150 mg three doses alternate days

MORE

Sir when i eat food my stomach is paining I take cipro 500 tab & meftalspas both bd for three days but my stumach still paining so what can i do. Please give me any advise

Dr. Pushkar Mani

Physician

consult physician and admit, could be gastritis

MORE

I suffering from bacterial infections in my shaving area or too much acne problem.

Dr. Atul Jain

Dermatology

Fudic cream twice a day

MORE

User feedback

Patients taking Cipro 250mg Tablet

Twice A Day

60%

Thrice A Day

20%

Once A Day

20%

What are you using Cipro Tablet for?

Others

100%

FAQs

Q. Is Cipro 250mg Tablet safe?

Cipro 250mg Tablet is a relatively safe drug. However, it is not devoid of side effects and hence should only be taken if prescribed by a doctor in the appropriate dose, frequency, and duration as advised.

Q. Can the use of Cipro 250mg Tablet cause diarrhea?

Yes, the use of Cipro 250mg Tablet can cause diarrhea. It is an antibiotic which kills the harmful bacteria. However, it also affects the helpful bacteria in your stomach or intestine and causes diarrhea. If you are experiencing severe diarrhea, talk to your doctor about it.

Q. Can I stop taking Cipro 250mg Tablet when I feel better?

No, do not stop taking Cipro 250mg Tablet and complete the full course of treatment even if you feel better. Your symptoms may improve before the infection is completely cured.

Q. Can the use of Cipro 250mg Tablet increase the risk of muscle damage?

Yes, use of Cipro 250mg Tablet is known to increase the risk of muscle damage, commonly in the ankle (achilies tendon). Muscle damage can happen in people of all ages who take Cipro 250mg Tablet. Inform your doctor if you feel any kind of muscle pain while using this medicine.

Q. Can I take Cipro 250mg Tablet with paracetamol?

Cipro 250mg Tablet is not known to have any clinically meaningful interaction with paracetamol. However, interactions can occur. Talk to your doctor before using both the medicines together.

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Disclaimer:

Tata 1mg’s sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

1. Petri WA Jr. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1473-74.

2. Chambers HF, Deck DH. Sulfonamides, Trimethoprim, & Quinolons. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 819-20.

3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 275-78.

4. Ciprofloxacin. [Accessed 01 Apr. 2019] (online) Available from:

5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-98. [Accessed 01 Apr. 2019] (online) Available from:

6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:

Manufacturer

Name: Torrent Pharmaceuticals Ltd

Address: Off. Ashram Road, Ahmedabad – 380 009. , Gujarat, India

Country of origin: India

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Ciprolet 250 mg № 10 tab (Ciprofloxacin)

Instructions for medical use
medicinal product
Ciprolet

Trade name
Ciprolet

International non-proprietary name
Ciprofloxacin 9 0005

Dosage form
Coated tablets, 250 mg, 500 mg

Composition
One tablet contains
active substance – ciprofloxacin 250 mg or 500 mg, colloidal silicon dioxide, purified talc, magnesium stearate,
shell composition: hypromellose, sorbic acid, titanium dioxide, purified talc, macrogol (6000), polysorbate 80, dimethicone.

Description
White film-coated tablets with a biconvex surface and smooth on both sides, height (4.10 ± 0.20) mm and diameter (11.30 ± 0.20) mm (for a dosage of 250 mg) or height (5.50 ± 0.20) mm and a diameter (12.60 ± 0.20) mm (for doses doses of 500 mg).

Pharmacotherapeutic group
Antimicrobials for systemic use. Fluoroquinolones.
ATC code J01MA02

Pharmacological properties
Pharmacokinetics
Rapidly absorbed from the gastrointestinal tract. Bioavailability after oral administration is 70%. Food intake has little effect on the absorption of ciprofloxacin. The plasma concentration profile of oral ciprofloxacin is similar to that of intravenous administration, so oral and intravenous routes of administration can be considered interchangeable. Communication with plasma proteins is 20 – 40%. The mean half-life of ciprofloxacin is 6 to 8 hours after a single or multiple dose. Ciprofloxacin penetrates well into organs and tissues: lungs, bronchial mucosa and sputum; organs of the genitourinary system, including the prostate gland; bone tissue, cerebrospinal fluid, polymorphonuclear leukocytes, alveolar macrophages. It is excreted mainly in urine and bile.

Pharmacodynamics
Ciprolet is a broad-spectrum antibiotic from the group of fluoroquinolones. Suppresses bacterial DNA gyrase (topomerase II and IV, responsible for the process of supercoiling of chromosomal DNA around nuclear RNA, which is necessary for reading genetic information), disrupts DNA synthesis, growth and division of bacteria; causes pronounced morphological changes (including the cell wall and membranes) and rapid death of the bacterial cell. It acts bacteriostatically on gram-negative microorganisms during the dormant period and bactericidal during the division period (since it affects not only DNA gyrase, but also causes cell wall lysis), on gram-positive microorganisms it is bactericidal only during the division period. Low toxicity to macroorganism cells is explained by the absence of DNA gyrase in them. Ciprolet is active against most strains of microorganisms in vitro and in vivo:
– aerobic gram-positive microorganisms: Corynebacterium diphtheriae, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus spp., including Staphylococcus aureus, epidermidis, Streptococcus pyogenes, agalactiae, pneumoniae, Streptococcus (groups C, G), Viridans group streptococci;
– Aerobic gram-negative microorganisms: Acinetobacter spp., including Acinetobacter anitratus, baumannii, calcoaceticus, Actinobacillus actinomycetemcomitans, Bordetella pertussis, Citrobacter freundii, diversus, Enterobacter spp., including Enterobacter aerogenes, agglomerans, cloacae, s akazakii, Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, influenzae, Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. , including Klebsiella oxytoca, pneumoniae, Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, including Pasteurella canis, dagmatis , multocida, Proteus mirabilis, vulgaris, Providencia spp., including Pseudomonas aeruginoza, fluorescens, Salmonella spp., Serratia spp., including Serratia marcescens;
– anaerobic microorganisms: Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus, Propionibacterium spp., Veillonella spp.;
– intracellular microorganisms: Streptococcus pneumoniae, Enterococcus faecalis, Chlamydia pneumoniae, psittaci, trachomatis, Legionella spp., including Legionella pneumophila, Mycobacterium spp., including Mycobacterium leprae, tuberculosis, Mycoplasma pneumoniae; Rickettsia spp.,
Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroids, Bacteroides fragilis , Pseudomonas cepatica, Pseudomonas maltophilia, Treponema pallidum 9 are resistant to Ciprolet0005

Indications for use
– ENT infections (otitis media, sinusitis, frontal sinusitis, mastoiditis, tonsillitis)
– respiratory diseases (exacerbation of chronic bronchitis, pneumonia)
– uncomplicated and complicated urinary tract infections (including pyelonephritis, prostatitis, adnexitis, endometritis) 900 03 – sexually transmitted infections (gonorrhea, chancre, urogenital chlamydia)
– infections of the gastrointestinal tract (peritonitis, intra-abdominal abscesses, salmonellosis, typhoid fever, campillobacteriosis, yersiniosis) and biliary tract
– infections of the skin and soft tissues (suppurated atheroma, abscess, boils)
– infections of bones and joints (osteomyelitis, septic arthritis)
– prevention of infections in surgical interventions
– septicemia
– prevention and treatment of infections in patients with reduced immunity (for example, during treatment with immunosuppressants, with neutropenia)

Method of administration and doses
Ciprolet® in tablets is administered to adults by mouth, before meals or between meals, without chewing, drinking plenty of liquid. When taken on an empty stomach, the active substance is absorbed faster. Ciprofloxacin tablets should not be taken with dairy products (eg milk, yogurt) or fruit juices with added minerals.
Doses are determined by the nature and severity of the infection, as well as the sensitivity of the suspected pathogen, the patient’s kidney function, and in children and adolescents, the patient’s body weight is taken into account.
The dose is determined based on the indication, type and severity of infection, sensitivity to ciprofloxacin, treatment depends on the severity of the disease, as well as clinical and bacteriological processes.
In the treatment of infections caused by certain bacteria (eg, Pseudomonas aeruginosa, Acinetobacter, or Stafilococ), higher doses of ciprofloxacin are required and may be combined with one or more other suitable antibacterial drugs.
In the treatment of certain infections (eg, pelvic inflammatory disease in women, intra-abdominal infections, infections in neutropenic patients, bone and joint infections), the combination of one or more compatible antibacterial drugs is possible, depending on the pathogens that cause them.