How do ciprofloxacin ear drops work to treat bacterial ear infections. What are the potential side effects of using ciprofloxacin ear drops. When should you consult a doctor while using ciprofloxacin ear drops. How to properly administer ciprofloxacin ear drops for maximum effectiveness.

Understanding Ciprofloxacin Ear Drops: A Powerful Treatment for Bacterial Ear Infections

Ciprofloxacin ear drops are a potent medication used to combat bacterial ear infections, particularly swimmer’s ear and ear canal infections. As a member of the quinolone antibiotic family, ciprofloxacin works by inhibiting bacterial growth, effectively halting the progression of the infection. However, it’s crucial to understand that this medication is specifically designed for bacterial ear infections and will not be effective against other types of ear ailments.

Is ciprofloxacin suitable for all types of ear infections? No, it’s important to note that ciprofloxacin ear drops are only effective against bacterial infections. Using antibiotics unnecessarily or excessively can lead to decreased effectiveness over time, potentially contributing to antibiotic resistance.

Proper Administration of Ciprofloxacin Ear Drops: Ensuring Optimal Results

Administering ciprofloxacin ear drops correctly is crucial for achieving the best possible outcomes. Here’s a step-by-step guide to help you use this medication effectively:

1. Warm the container by holding it in your hand for a few minutes to minimize dizziness.
2. Wash your hands thoroughly before handling the medication.
3. Avoid touching the dropper tip to prevent contamination.
4. Lie on your side or tilt your head with the affected ear facing upward.
5. Gently pull the earlobe up and back for adults, or down and back for children.
6. Empty the contents of the single-use container into the ear canal.
7. Maintain the tilted head position for at least one minute.
8. Discard any unused solution after each application.

How often should ciprofloxacin ear drops be administered? Typically, the medication is prescribed for use twice daily, approximately every 12 hours, for a duration of 7 days. However, always follow your doctor’s specific instructions regarding dosage and duration of treatment.

Potential Side Effects: What to Watch For When Using Ciprofloxacin Ear Drops

While ciprofloxacin ear drops are generally well-tolerated, some individuals may experience side effects. It’s essential to be aware of these potential reactions and know when to seek medical attention:

• Mild discomfort, pain, or itching in the ear
• Allergic reactions (rare but serious)
• Risk of new bacterial or fungal infections with prolonged use

When should you contact your doctor about side effects? If you experience persistent or worsening discomfort, pain, or itching in the ear, it’s important to notify your healthcare provider promptly. Additionally, seek immediate medical attention if you notice any signs of a serious allergic reaction, such as rash, itching/swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.

Precautions and Interactions: Ensuring Safe Use of Ciprofloxacin Ear Drops

Before using ciprofloxacin ear drops, it’s crucial to inform your healthcare provider about any allergies, especially to quinolone antibiotics, and any other medications you may be taking. This information helps prevent potential adverse reactions and ensures the safe use of the medication.

Can ciprofloxacin ear drops be used during pregnancy or while breastfeeding? The use of ciprofloxacin ear drops during pregnancy should be carefully considered and only used when clearly necessary. The risks and benefits should be discussed with your healthcare provider. It is currently unknown whether ciprofloxacin from ear drops passes into breast milk, so it’s essential to consult your doctor before using this medication while breastfeeding.

Maximizing the Effectiveness of Ciprofloxacin Ear Drops: Tips for Optimal Treatment

To ensure the best possible outcomes when using ciprofloxacin ear drops, consider the following tips:

• Use the medication consistently at the same times each day
• Complete the full course of treatment, even if symptoms improve
• Avoid using the medication for longer than prescribed
• Keep the treated ear facing upward for at least one minute after application
• Use a soft cotton plug if directed by your healthcare provider

Why is it important to complete the full course of treatment? Stopping the medication prematurely may allow bacteria to continue growing, potentially leading to a recurrence of the infection. Always follow your doctor’s instructions regarding the duration of treatment.

Recognizing Signs of Improvement and When to Seek Further Medical Attention

While using ciprofloxacin ear drops, it’s important to monitor your condition and be aware of signs that may indicate the need for further medical evaluation:

• Persistent or worsening symptoms after 7 days of treatment
• Development of new symptoms or side effects
• No improvement in your condition after completing the full course of treatment

How can you determine if the treatment is working? You should experience a gradual reduction in pain, discomfort, and other symptoms associated with the ear infection. If you don’t notice any improvement or if your condition worsens, it’s crucial to contact your healthcare provider for further evaluation and potential adjustment of your treatment plan.

Understanding the Limitations and Proper Storage of Ciprofloxacin Ear Drops

To maintain the effectiveness and safety of ciprofloxacin ear drops, it’s essential to understand their limitations and proper storage:

• Use the medication only in the ear(s) as directed
• Do not use the drops in the eyes, inject, or inhale the medication
• Store the medication according to the instructions on the packaging
• Discard any unused solution after each application
• Do not use the medication past its expiration date

How should ciprofloxacin ear drops be stored? Generally, these drops should be stored at room temperature, away from light and moisture. However, always refer to the specific storage instructions provided with your medication, as requirements may vary between different formulations.

Potential Drug Interactions with Ciprofloxacin Ear Drops

While ciprofloxacin ear drops are applied topically and are less likely to interact with other medications compared to oral antibiotics, it’s still important to be aware of potential interactions:

• Inform your doctor about all medications you’re currently taking, including over-the-counter drugs and herbal supplements
• Be particularly cautious if you’re taking other ear medications or treatments
• Avoid using other ear drops or inserting objects into the ear without consulting your healthcare provider

Can ciprofloxacin ear drops interact with systemic medications? While the risk is generally low due to the localized application, it’s always best to disclose all medications to your healthcare provider to ensure there are no potential interactions that could affect your treatment or overall health.

The Importance of Proper Ear Care During and After Treatment

Maintaining good ear hygiene and care practices can help support the effectiveness of ciprofloxacin ear drops and promote faster healing:

• Keep the ear dry during treatment, unless otherwise instructed by your doctor
• Avoid swimming or submerging your head in water until the infection has cleared
• Use earplugs or a swim cap to protect your ears if water exposure is unavoidable
• Gently clean the outer ear with a soft cloth, avoiding insertion into the ear canal
• Avoid using cotton swabs or other objects to clean inside the ear canal

How can you protect your ears from future infections? After treatment, continue to practice good ear hygiene, such as drying your ears thoroughly after swimming or bathing, and avoiding the insertion of foreign objects into the ear canal. If you’re prone to swimmer’s ear, consider using ear drops designed to help prevent bacterial growth after water exposure.

Understanding the Role of Ciprofloxacin in Antibiotic Stewardship

As antibiotic resistance becomes an increasingly concerning global health issue, it’s crucial to understand the role of medications like ciprofloxacin ear drops in antibiotic stewardship:

• Use the medication only as prescribed for bacterial ear infections
• Do not save leftover medication for future use
• Avoid sharing your prescription with others, even if they have similar symptoms
• Complete the full course of treatment to help prevent the development of resistant bacteria

Why is antibiotic stewardship important? Responsible use of antibiotics helps maintain their effectiveness for future treatments, reducing the risk of developing antibiotic-resistant bacteria. By using ciprofloxacin ear drops appropriately, you’re contributing to this important public health effort.

Exploring Alternative Treatments for Ear Infections

While ciprofloxacin ear drops are effective for bacterial ear infections, it’s worth noting that not all ear infections require antibiotic treatment. In some cases, alternative approaches may be recommended:

• Watchful waiting for mild cases that may resolve on their own
• Over-the-counter pain relievers to manage discomfort
• Warm compresses applied to the affected ear
• Ear drops containing acetic acid or alcohol for swimmer’s ear prevention

When are alternative treatments appropriate? Your healthcare provider will assess the severity and type of your ear infection to determine the most suitable treatment approach. In some cases, a combination of treatments may be recommended for optimal results.

The Future of Ear Infection Treatments: Ongoing Research and Developments

As medical science continues to advance, researchers are exploring new approaches to treating ear infections and improving existing treatments:

• Development of new antibiotic formulations with enhanced effectiveness
• Exploration of non-antibiotic treatments to combat antibiotic resistance
• Advancements in drug delivery systems for improved medication absorption
• Research into preventive measures and early intervention strategies

How might future developments impact ear infection treatments? Ongoing research may lead to more targeted therapies, reduced side effects, and potentially even preventive measures that could significantly reduce the incidence of ear infections. Stay informed about these developments by consulting with your healthcare provider and following reputable medical news sources.

The Psychological Impact of Ear Infections and Treatment

While the physical symptoms of ear infections are well-documented, it’s also important to consider the psychological impact of these conditions and their treatment:

• Anxiety or stress related to the discomfort and potential hearing impairment
• Frustration with the treatment process, especially for recurrent infections
• Concerns about potential complications or long-term effects
• Impact on daily activities and quality of life during the infection and treatment period

How can patients cope with the psychological aspects of ear infections? Open communication with your healthcare provider about your concerns, seeking support from family and friends, and practicing stress-reduction techniques can all help manage the emotional impact of ear infections and their treatment.

Educating Others: Spreading Awareness About Proper Ear Care and Infection Prevention

As someone who has experienced an ear infection and undergone treatment with ciprofloxacin ear drops, you can play a role in educating others about proper ear care and infection prevention:

• Share your experience and the importance of seeking prompt medical attention
• Promote good ear hygiene practices among family and friends
• Raise awareness about the responsible use of antibiotics
• Encourage others to be proactive about their ear health

Why is community education important for ear health? By sharing knowledge and promoting good practices, you can help reduce the incidence of ear infections in your community and contribute to overall public health awareness.

Ciprofloxacin Otic (Ear): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Ciprofloxacin is used to treat bacterial ear infections (swimmer’s ear or ear canal infections). It works by stopping the growth of bacteria. This medication belongs to a class of drugs called quinolone antibiotics.This medication treats only bacterial ear infections. It will not work for other types of ear infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

How to use Ciprofloxacin Hcl Dropperette, Single Use Dropper

Learn all preparation and usage instructions before using this medication. For accuracy and to avoid contamination, have another person give the drops if possible. Hold the container in your hand for a few minutes to warm it. This will minimize dizziness. Wash your hands before opening/using the medication. To avoid contamination, do not touch the dropper tip or let it touch your ear or any other surface.

Use this medication in the infected ear as directed by your doctor, usually twice daily (every 12 hours) for 7 days. Use in the ear only. Do not use in the eyes, inject, or inhale the medication.

Lie on your side or tilt your head with the ear to be treated facing upward. Hold the container directly over the ear, and empty the contents of the single-use container into the ear canal. While placing the solution into the ear of an adult, the earlobe should be gently pulled up and back to allow the drops to flow down into the ear canal. For children, gently pull the earlobe down and back. Keep the head tilted with the treated ear upward for at least 1 minute or insert a soft cotton plug if so directed. Discard any unused solution after each application. Do not reuse.

Repeat the above steps for the other ear if so directed.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Continue using it for the full time prescribed, even if symptoms disappear after a few days. Stopping this medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

Inform your doctor if your condition lasts or gets worse after 7 days of treatment.

Side Effects

Discomfort, pain, or itching in the ear may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Use of this medication for prolonged or repeated periods may result in a new bacterial/fungal ear infection. Do not use this medication for longer than prescribed. Contact your doctor if you notice new or worsening symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this medication, tell your doctor or pharmacist if you are allergic to it or to other quinolone antibiotics (such as ofloxacin, levofloxacin), or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if ciprofloxacin in this ear drop passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Ciprofloxacin Hcl Dropperette, Single Use Dropper interact with other drugs you are taking?

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Overdose

This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Throw away the unused medication after treatment is completed. Do not use it later for another infection unless your doctor tells you to.

It is important to keep the infected ear(s) clean and dry. Try not to get the infected ear(s) wet when bathing. Avoid swimming unless your doctor tells you otherwise.

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature in the original pouch to protect from light. Do not freeze. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Ciprofloxacin Otic: MedlinePlus Drug Information

pronounced as (sip roe flox’ a sin)

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Ciprofloxacin otic solution (Cetraxal) and ciprofloxacin otic suspension (Otiprio) are used to treat outer ear infections in adults and children. Ciprofloxacin otic suspension (Otiprio) is also used in children during ear tube placement surgery to prevent infection or ear drainage. Ciprofloxacin otic is in a class of medications called quinolone antibiotics. It works by killing the bacteria that cause infection.

Ciprofloxacin otic (Cetrexal) comes as a solution (liquid) to place into the ear. It is usually used twice a day for 7 days. Use ciprofloxacin otic solution at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use ciprofloxacin otic exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Ciprofloxacin otic (Otiprio) also comes as a suspension (liquid) to be placed into the ear by a doctor or nurse in a doctor’s office or other medical facility. Ciprofloxacin otic suspension (Otiprio) is usually given as a single dose.

Ciprofloxacin otic is only for use in the ears. Do not use in the eyes.

You should begin to feel better during the first few days of treatment of out ear infections with ciprofloxacin otic. If your symptoms do not improve after one week or get worse, call your doctor. Also, call your doctor if you have ear pain, continuous ear discharge, or fever following use during ear tube surgery.

Ciprofloxacin otic (Cetrexal) ear drops come in single-use containers (small bottles to be used for one dose). Use the liquid from the container immediately after opening, and throw away the container when you are finished. Use ciprofloxacin otic ear drops until you finish the prescription, even if you feel better. If you stop using ciprofloxacin otic too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

To use the eardrops, follow these steps:

1. Wash your hands thoroughly.
2. Hold the container in your hand for at least 1 minute to warm the solution.
3. Twist off the top of the container.
4. Lie down with the affected ear upward.
5. Place the entire contents of the container into your ear.
6. Remain lying down with the affected ear upward for at least 60 seconds.
7. Repeat steps 1-6 for the opposite ear if necessary.
8. Throw away the empty container(s) in a trash can.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using ciprofloxacin otic,

• tell your doctor and pharmacist if you are allergic to ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), nalidixic acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), any other medications, or any of the ingredients in ciprofloxacin otic. Ask your doctor or pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using ciprofloxacin otic, call your doctor.
• you should know that you must keep your infected ear(s) clean and dry while using ciprofloxacin otic. Avoid getting the infected ear(s) wet while bathing, and avoid swimming unless your doctor has told you otherwise.

Unless your doctor tells you otherwise, continue your normal diet.

Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use extra eardrops to make up for a missed one.

Ciprofloxacin otic may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• ear discomfort, pain, or itching

Some side effects can be serious. If you experience any of these symptoms, stop using ciprofloxacin otic and call your doctor immediately

• rash
• hives
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
• hoarseness
• difficulty swallowing or breathing

Ciprofloxacin otic may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

• Cetraxal^®
• Otiprio^®

Last Revised – 05/15/2018

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Dosage, side effects, active substance, composition

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED.Antibiotics in tablets SinusitisPyelonephritisProstatitisCystitis

Author of the article

Podoinitsyna Alena Andreevna,

Diploma of pharmaceutical education: 105924 351072 2 reg. number 31917

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Contents of the article

• Ciprofloxacin: active ingredient
• Ciprofloxacin: indications for use
• Ciprofloxacin: dosage
• Ciprofloxacin: side effects
• Ciprofloxacin and alcohol: compatibility
• Ciprofloxacin or Levofloxacin: which is better
• Summary
• Ask an expert on the topic of the article

Sore throat worse when swallowing, fever and chills, body aches – all these are signs of a sore throat or, in other words, acute tonsillitis. In cases where the throat is covered with a yellowish-white purulent coating, and the cervical lymph nodes are enlarged, we can talk about the bacterial nature of the disease. In such a situation, the only possible treatment is antibacterial drugs. One of them will be discussed in the article.

Alena Podoinitsyna, a pharmacist, will tell you about Ciprofloxacin: introduce its active ingredient, indications for use, contraindications, and compare it with its analogue – Levofloxacin.

Ciprofloxacin: active ingredient

Ciprofloxacin is an antimicrobial agent with the active ingredient of the same name. The drug has a bactericidal effect against a number of bacteria. In other words, it causes their death.

According to the State Drug Registry or State Drug Administration: Ciprofloxacin is produced in several dosage forms: tablets, intravenous solution, eye and ear drops. There is no such form as Ciprofloxacin ointment.

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Ciprofloxacin: indications for use

Ciprofloxacin tablets and solution for infusion are used to treat infections caused by susceptible microorganisms. These can be infections of the respiratory tract, middle ear, eyes, kidneys, urinary tract and other organs. If we talk about specific diseases of a bacterial nature, then Ciprofloxacin is prescribed:

Ciprofloxacin has contraindications. For example, hypersensitivity to the components of the drug, simultaneous use with certain drugs and children’s age. In addition, the use of Ciprofloxacin during pregnancy is contraindicated.

Ciprofloxacin: dosage

The daily dose and duration of administration is determined by the doctor based on the type of disease and the severity of its symptoms. For example, for the treatment of uncomplicated respiratory tract infections, ciprofloxacin 500 mg 2 times a day is usually prescribed.

Ciprofloxacin side effects

Ciprofloxacin causes the following side effects:

• Eosinophilia – increased number of eosinophils – blood cells
• Allergic reactions: urticaria, skin rash, angioedema
• Loss of appetite
• Psychomotor hyperactivity
• Headache and dizziness
• Sleep and taste disorders
• Visual disorders
• Tinnitus
• Palpitations
• Respiratory failure
• Nausea and diarrhea
• Increased activity of liver enzymes
• Joint pain
• Renal disorders
• Pain syndrome of non-specific etiology

Ciprofloxacin and alcohol compatibility

Do not take ciprofloxacin and alcohol together. This combination will minimize the effectiveness of the drug, which means that the bacteria will continue to grow and multiply. In addition, it is possible to increase adverse reactions: a detrimental effect on the liver and intestinal microflora or a disruption in the functioning of the nervous system.

Ciprofloxacin or Levofloxacin: which is better

Levofloxacin is a synthetic antimicrobial agent belonging to the same group as Ciprofloxacin. It is produced in the form of tablets, solution for intravenous administration and eye drops.

The spectrum of antimicrobial activity of Levofloxacin is wider. For example, the drug is effective against Staphylococcus aureus and chlamydia. Ciprofloxacin, due to its mechanism of action, causes bacterial resistance or resistance more often than other drugs.

You cannot choose which drug is better: Ciprofloxacin or Levofloxacin. The final decision on the appointment of a particular drug is made by the doctor.

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Summary

• Ciprofloxacin is an antimicrobial agent with the same active ingredient.
• Ciprofloxacin tablets and solution for infusion are used for infections caused by susceptible organisms.
• Daily doses and duration of administration are determined by the doctor based on the type of disease and the severity of its symptoms.
• Do not take ciprofloxacin and alcohol together.
• It is impossible to choose which drug is better: Ciprofloxacin or Levofloxacin.

Ask an expert about the topic of the article

Still have questions? Ask them in the comments below and our experts will answer you. There you can also share your experience with other readers of Megasovets.

Editor-in-chief

Zotina Natalya Igorevna,

Expert pharmacist

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instructions for use, price, analogues, composition, indications

Clear, colorless or slightly greenish solution.

Per vial:

active substance: ciprofloxacin (as ciprofloxacin hydrochloride) – 15.0 mg;

excipients: mannitol (mannitol), benzalkonium chloride, sodium acetate trihydrate, disodium edetate (E 386), glacial acetic acid, water for injection.

Means used in ophthalmology.

Antimicrobial agents.

ATC code: S01AE03.

Antimicrobial drug. Acts bactericidal. While taking ciprofloxacin, there is no parallel development of resistance to aminoglycosides, penicillins, cephalosporins, tetracyclines. Ciprofloxacin has shown high activity in in vitro studies against many gram-negative microorganisms, including Pseudomonas aeruginosa. It is also effective against gram-positive bacteria such as staphylococci and streptococci. Anaerobic bacteria are generally less sensitive.

In vitro and in vivo studies have established the activity of ciprofloxacin against the following microorganisms (MIC ≤ 1 μg / ml):

Gram-positive: Staphylococcus aureus (methicillin-susceptible), Staphylococcus epidermidis (methicillin-susceptible), Streptoc occus pneumoniae, Streptococcus ( group Viridans).

Gram-negative: Acinetobacter sp., Haemophilus sp., Pseudomonas aeruginosa, Serratia marcescens.

In vitro studies have established the activity of ciprofloxacin against most strains of the following microorganisms, although the clinical significance of these data has not been established:

Gram-positive: Bacillus cereus, Corynebacterium sp., Enterococcus faecalis (many strains are moderately susceptible), Micrococcus sp., Staphylococcus capitis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Sta phylococcus warneri, Streptococcus pyogenes.

Gram-negative: Aeromonas caviae, Aeromonas hydrophila, Brucella melitensis, Campylobacter coli, Campylobacter jejuni, Citrobacter sp., Edwardsiella tarda, Enterobacter sp., Escherichia coli, Haemophil us parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumophila, Moraxella sp. , Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Providencia sp., Salmonella enteritidis, Salmonella typhi, Shigella sonneii, Shigella flexneri, Vibrio cholera, Vibrio parahaemolyticus, Vibrio vulnific us, Yersinia enterocolitica.

Other organisms: Chlamydia trachomatis and Mycobacterium only moderately sensitive (MIC > 1 µg/mL, < 9014 4 2 µg/ml) . Most strains of Pseudomonas cepacia and some strains of Pseudomonas maltophilia are resistant to ciprofloxacin, as are most anaerobic bacteria, including Bacteroides fragilis and Clostridium difficile (MIC > 4 µg/ml) .

Controlled clinical trials to study the effectiveness of the drug in chlamydial infection have not been conducted. Therefore, the drug is not suitable for the treatment of chlamydial infection.

Superficial infectious and inflammatory diseases of the eyes, such as conjunctivitis, blepharitis and blepharoconjunctivitis; bacterial corneal ulcers caused by microorganisms susceptible or suspected to be susceptible to ciprofloxacin, in particular Pseudomonas aeruginosa and other gram-negative pathogens resistant to standard treatments.

– wash your hands before instillation;

– tilt your head back;

– lower the edge of the lower eyelid with your finger until a “pocket” is formed between the eyelid and your eye;

– without touching the eye or eyelid, adjacent areas or other surfaces with parts of the dropper, drop the drug into the formed “pocket” in the amount of kazel indicated in the instructions;

– if necessary, repeat the steps for the other eye;

– if you missed the time of instillation, do not use a double dose, just use the drug when the next time comes;

– if you accidentally instill more ciprofloxacin than required according to the instructions, rinse your eyes with warm water.

Adults and children over 1 year:

Superficial bacterial infections of the eye and its appendages (bacterial conjunctivitis/blepharitis):

– 1 – Day 2: 1-2 drops during the day every 2 hours into the conjunctival sac of inflamed eyes;

– 3 – Day 7: every 4 hours, 1-2 drops are instilled into the conjunctival sac of inflamed eyes.

If longer treatment is required, the dose is determined by the doctor.

In case of a bacterial corneal ulcer, 2 drops of the drug are instilled every 15 minutes for 6 hours, then 2 drops every 30 minutes during waking hours on the 1st day; on the 2nd day – 2 drops every hour during waking hours; from 3 to 14 days – 2 drops every 4 hours during waking hours. If after 14 days of therapy epithelialization has not occurred, treatment can be continued.

The maximum duration of treatment for any of the diagnoses is 21 days.

Elderly patients. The efficacy and safety of ciprofloxacin eye drops do not differ between older and younger patients.

Children. For children under 1 year of age, the safety and efficacy of the medicinal product has not been established. Although oral ciprofloxacin and other fluoroquinolones cause arthropathy in young animals, ciprofloxacin does not cause arthropathy when instilled into the eye, and there is no evidence of an effect of ophthalmic doses on the supporting joints of young animals.

Allergic reactions, itching, burning, mild soreness and hyperemia of the conjunctiva, nausea; rarely – swelling of the eyelids, photophobia, lacrimation, sensation of a foreign body in the eyes, an unpleasant aftertaste in the mouth immediately after instillation, decreased visual acuity, the appearance of a white crystalline precipitate in patients with a corneal ulcer, keratitis, keratopathy, the appearance of spots or infiltration of the cornea, the development of superinfection, prolongation of the QT interval on the electrocardiogram.

In case of adverse reactions, including those not listed in this leaflet, you should consult a doctor.

Hypersensitivity to ciprofloxacin or other drugs of the quinolone group, hypersensitivity to the auxiliary components of the drug, viral and fungal eye lesions, glucose-6-phosphate dehydrogenase deficiency, pregnancy and lactation (breastfeeding should be stopped for the period of treatment), children under 1 year of age ( for eye drops).

There are no data on drug overdose.

In case of an overdose of the drug when applied topically, the excess solution should be removed by rinsing the eyes with plenty of warm running water.

After instillation of the solution into the eyes to reduce systemic absorption, it is recommended:

– hold the eyelid closed for 2 minutes;

– squeeze the tear duct with your finger for 2 minutes.

This medicine contains benzalkonium chloride, which may cause eye irritation.

Since hypersensitivity reactions cannot be excluded during treatment, the drug should be discontinued at the first sign of redness or other symptoms of hypersensitivity.

Do not use the drug for infections associated with deeper structures of the eye.

Serious, life-threatening anaphylactic-type hypersensitivity reactions have been reported following systemic administration of quinolones. Reactions are manifested by cardiovascular disorders, loss of consciousness, swelling of the pharynx or face, shortness of breath, urticaria and itching. Only a small proportion of these patients had a history of hypersensitivity reactions. Serious anaphylactic reactions require immediate emergency care with the introduction of adrenaline and other resuscitation measures.

As with other antibacterial agents, long-term use of ciprofloxacin may lead to the development and growth of resistant strains of bacteria or fungi. In case of superinfection, appropriate therapy should be initiated.

When prescribing eye drops containing antimicrobial agents, one should take into account the possible nasopharyngeal passage, which can lead to the development and spread of bacterial resistance.

The drug can only be applied topically; it should not be injected subconjunctivally or directly into the anterior chamber of the eye. When using other ophthalmic drugs, the interval between their administration should be at least 15 minutes.

During treatment with the drug, it is not recommended to wear soft contact lenses. When using hard contact lenses, remove them before instillation and put them back on 15-20 minutes after instillation of the drug.

The bottle must be closed after each use. Do not touch the tip of the pipette to the eye.

The drug should be used with caution in patients with cerebral atherosclerosis, cerebrovascular accident, convulsive syndrome, with known risk factors for prolongation of the QT interval.

Patients should be aware that if conjunctival hyperemia continues or increases after the use of drops for a long time, stop using the drug and consult a doctor.

Use during pregnancy and lactation

The use of the drug during pregnancy and lactation is contraindicated (breastfeeding should be stopped for the period of treatment).

Influence on the ability to drive vehicles and other potentially dangerous mechanisms

Patients who temporarily lose their vision after using ciprofloxacin eye drops should not drive a car or work with complex equipment immediately after instillation of the drug.

Studies on the interaction of ciprofloxacin in the form of eye drops with other drugs have not been conducted. With the systemic administration of some quinolones, an increase in the plasma concentration of theophylline, an effect on the metabolism of caffeine, and an increase in the effects of oral anticoagulants, warfarin and its derivatives were observed. In addition, there was a transient increase in serum creatinine in patients who simultaneously received cyclosporine.

Incompatibilities: ciprofloxacin eye drops are incompatible with alkaline solutions.

Store in a place protected from light at a temperature not exceeding 25 ° C.

Store the opened vial in a place protected from light at a temperature of 15 ° C to 25 ° C for 4 weeks.

Keep out of the reach of children.

Do not use the medicine after the expiration date.

2 years.

5 ml in glass vials. One bottle, complete with a dropper cap and instructions for use, is placed in a cardboard box.