What is Colace and how does it work. What are the uses and benefits of Colace. How to take Colace safely and effectively. What are the potential side effects of Colace. Who should not use Colace. How does Colace compare to other stool softeners. What precautions should be taken when using Colace.

Understanding Colace: A Gentle Stool Softener for Constipation Relief

Colace, also known by its generic name docusate sodium, is a popular over-the-counter stool softener used to treat and prevent occasional constipation. As a laxative, it works by increasing the amount of water the stool absorbs in the intestines, making bowel movements softer and easier to pass.

What sets Colace apart from other laxatives? Unlike stimulant laxatives that can cause cramping, Colace works gently by softening the stool, typically producing a bowel movement within 12 to 72 hours after ingestion.

Key Components of Colace

• Active ingredient: Docusate Sodium 100mg
• Inactive ingredients: Edible ink, FD&C Red #40, FD&C Yellow #6, Gelatin, Glycerin, Polyethylene Glycol, Propylene Glycol, Purified Water Sorbitan, Sorbitol

The Mechanism of Action: How Colace Relieves Constipation

How exactly does Colace work to alleviate constipation? Docusate sodium, the active ingredient in Colace, is a surfactant that lowers the surface tension of the stool. This allows water and fats to penetrate the stool, softening it and making it easier to pass through the intestines.

What makes Colace different from other types of laxatives? Unlike osmotic or stimulant laxatives, Colace doesn’t draw water into the intestines or stimulate peristalsis. Instead, it works by changing the physical properties of the stool itself, making it a gentler option for many people.

Indications and Uses: When to Consider Colace

When might a healthcare provider recommend Colace? This stool softener is typically used for:

• Relieving occasional constipation
• Preventing constipation in certain medical conditions
• Reducing pain or rectal damage caused by hard stools
• Easing bowel movements after surgery or childbirth

Is Colace suitable for long-term use? While it’s generally safe for short-term relief of constipation, it’s not recommended for prolonged use without medical supervision. Chronic constipation may indicate an underlying health issue that requires further investigation.

Proper Usage and Dosage Guidelines for Colace

How should you take Colace for optimal results? The recommended dosage varies depending on age and individual needs:

• Adults and children 12 years and over: 1 to 3 softgels daily
• Children 2 to under 12 years: 1 softgel daily
• Children under 2 years: Consult a doctor

What’s the best way to take Colace? It’s important to take each dose with a full glass of water and maintain adequate fluid intake throughout the day. This helps the medication work effectively and prevents dehydration.

Tips for Taking Colace

1. Take doses as a single daily dose or in divided doses
2. Drink plenty of water throughout the day
3. Do not exceed the recommended dosage
4. If symptoms persist after 72 hours, consult a healthcare provider

Potential Side Effects and Precautions When Using Colace

While Colace is generally well-tolerated, what are some potential side effects to be aware of? Common side effects may include:

• Mild stomach cramps
• Nausea
• Diarrhea
• Throat irritation (when taking liquid forms)

When should you seek medical attention while taking Colace? Stop use and consult a doctor if you experience:

• Rectal bleeding
• No bowel movement after use
• Severe abdominal pain
• Symptoms that persist for more than a week

Contraindications: Who Should Avoid Using Colace?

While Colace is safe for many people, there are certain situations where its use is not recommended. Who should avoid using Colace?

• Individuals with known allergies to docusate sodium or any of the inactive ingredients
• People with intestinal blockages
• Those experiencing nausea, vomiting, or severe stomach pain
• Individuals taking mineral oil (unless directed by a doctor)

What precautions should be taken when considering Colace? Always consult a healthcare provider before use if you:

• Are pregnant or breastfeeding
• Have a history of stomach or intestinal problems
• Are taking other medications that may interact with Colace
• Have noticed sudden changes in bowel habits lasting more than two weeks

Comparing Colace to Other Stool Softeners and Laxatives

How does Colace stack up against other constipation remedies? Let’s compare it to some common alternatives:

Colace vs. Miralax

Miralax (polyethylene glycol 3350) is an osmotic laxative that works by drawing water into the colon. While both are effective for constipation relief, Miralax may work faster but can cause more watery stools.

Colace vs. Senokot

Senokot (senna) is a stimulant laxative that induces bowel movements by irritating the intestinal lining. It may work more quickly than Colace but has a higher risk of causing abdominal cramping.

Colace vs. Fiber Supplements

Fiber supplements like Metamucil work by adding bulk to the stool and promoting regularity. While they’re great for long-term use, they may not provide the immediate relief that Colace offers for occasional constipation.

What factors should you consider when choosing between Colace and other options? The choice depends on individual needs, the severity of constipation, and any underlying health conditions. Always consult a healthcare provider for personalized advice.

Lifestyle Changes to Complement Colace Use

While Colace can provide relief from constipation, what lifestyle changes can enhance its effectiveness and promote overall digestive health?

• Increase fiber intake through fruits, vegetables, and whole grains
• Stay hydrated by drinking plenty of water throughout the day
• Engage in regular physical activity to promote bowel movements
• Establish a regular bathroom routine
• Avoid holding in bowel movements when you feel the urge

How can these changes work in tandem with Colace? By adopting these habits, you may reduce your reliance on laxatives and improve your overall digestive health. Colace can be used as needed while you establish these healthier routines.

Understanding the Importance of Proper Constipation Management

Why is it crucial to address constipation promptly and effectively? Chronic constipation can lead to various complications, including:

• Hemorrhoids
• Anal fissures
• Fecal impaction
• Rectal prolapse

How can Colace play a role in preventing these issues? By softening stools and making them easier to pass, Colace can help reduce straining during bowel movements, which is a common cause of these complications.

When to Seek Medical Advice

While Colace can be effective for occasional constipation, when should you consult a healthcare provider? Seek medical attention if:

• Constipation persists for more than a week despite using Colace
• You experience sudden changes in bowel habits
• There’s blood in your stool
• You have unexplained weight loss
• You frequently need to use laxatives to have a bowel movement

Colace in Special Populations: Considerations for Pregnant Women and the Elderly

How does the use of Colace differ for certain groups of people? Let’s explore some special considerations:

Colace During Pregnancy

Is Colace safe for pregnant women? While generally considered safe, pregnant women should always consult their healthcare provider before using any medication. Colace may be recommended to prevent constipation, which is common during pregnancy.

Colace for the Elderly

How should older adults approach Colace use? Elderly individuals may be more susceptible to constipation due to reduced mobility, medications, or other health conditions. While Colace can be effective, it’s important to start with a lower dose and monitor for any adverse effects.

The Role of Colace in Post-Operative Care

Why is Colace often recommended after surgery? Post-operative constipation is a common issue due to factors such as:

• Pain medications
• Reduced mobility
• Changes in diet
• Anesthesia effects

How can Colace help in post-operative recovery? By preventing hard stools and reducing straining, Colace can help patients avoid discomfort and potential complications during recovery. However, it should always be used under medical supervision in these cases.

Exploring Alternative and Natural Remedies for Constipation

While Colace is an effective option, what natural alternatives exist for managing constipation? Some popular natural remedies include:

• Prunes or prune juice
• Flaxseed
• Chia seeds
• Aloe vera juice
• Magnesium supplements

How do these compare to Colace in terms of effectiveness? While natural remedies can be beneficial, their effects may vary from person to person. They often work best as part of a holistic approach to digestive health rather than as a quick fix for acute constipation.

The Future of Constipation Treatment: Beyond Colace

What developments are on the horizon for constipation treatment? Researchers are exploring new approaches, including:

• Probiotic therapies to promote gut health
• Novel pharmaceutical compounds targeting specific receptors in the gut
• Personalized treatment plans based on an individual’s gut microbiome

How might these advancements impact the use of traditional stool softeners like Colace? While Colace remains a reliable option for many, future treatments may offer more targeted and personalized solutions for chronic constipation.

Debunking Myths About Colace and Constipation

What common misconceptions exist about Colace and constipation treatment? Let’s address some myths:

Myth 1: Colace is Habit-Forming

Unlike stimulant laxatives, Colace does not cause physical dependence. However, overuse can lead to reliance on laxatives for regular bowel movements.

Myth 2: More is Better

Taking more than the recommended dose of Colace won’t necessarily lead to faster or better results. It may increase the risk of side effects.

Myth 3: Colace Works Instantly

Colace typically takes 12-72 hours to produce a bowel movement. It’s not designed for immediate relief of constipation.

By understanding these facts, how can users set realistic expectations for Colace use? Recognizing that Colace is a gentle, gradual solution can help users avoid misuse and appreciate its proper role in constipation management.

Major Docusate Sodium 100 mg

Now:

$5.99

UPC:

309046998600

Generic Equivalent:

Colace Regular Strength Stool Softener

Expiration Date:

10-2024

Current Stock:
16

Quantity:

Adding to cart… The item has been added

Product Overview

Major Docusate Sodium 100 mg – 100 Softgels (Colace Regular Strength Stool Softener)

• Compare to the active ingredient in Colace Regular Strength Stool Softener
• Stool softener laxative

Expiration Date: 10-2024

Ingredients

• Active: Docusate Sodium 100mg – Stool softener laxative
• Inactive: Edible Ink, FD&C Red #40, FD&C Yellow #6, Gelatin, Glycerin, Polyethylene Glycol, Propylene Glycol, Purified Water Sorbitan, Sorbitol 

Uses

• Relieves occasional constipation (irregularity)
• Generally produces bowel movement in 12 to 72 hours 

FULL DESCRIPTION

Drug Facts

Active Ingredients (in each softgel)

• Docusate Sodium – 100 mg
• Purpose: Stool softener laxative 

Uses

• Relieves occasional constipation (irregularity)
• Generally produces bowel movement in 12 to 72 hours 

Warnings

• Do Not Use
• If you are presently taking mineral oil, unless told to do so by a doctor

• Ask a Doctor Before Use if You Have
• Stomach pain
• Nausea
• Vomiting
• Noticed a sudden change in bowel habits that last over 2 weeks

• Stop Use and Ask a Doctor If
• You have rectal bleeding or fail to have a bowel movement after use of a laxative
• These could be signs of a serious condition
• You need to use a laxative for more than 1 week

• If Pregnant or Breast-Feeding
• Ask a health professional before use

• Keep Out of Reach of Children
• In case of overdose, get medical help or contact a Poison Control Center right away

Directions

• Take only by mouth
• Doses may be taken as a single daily dose or in divided doses
• Adults and children 12 years and over 
• Take 1 to 3 softgels daily

• Children 2 to under 12 years of age
• Take 1 softgel daily

• Children under 2 years
• Ask a doctor

Other Information

• Each softgel contains: Sodium 5mg
• Store at 25ºC (77ºF)
• Excursions permitted between 15º-30ºC (59º-86ºF)

Inactive 

• Edible Ink, FD&C Red #40, FD&C Yellow #6, Gelatin, Glycerin, Polyethylene Glycol, Propylene Glycol, Purified Water Sorbitan, Sorbitol

Colace: Side Effects, Uses, & Dosage

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Generic name: docusate [ DOK-ue-sate ]
Drug class: Laxatives

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 3, 2022.

What is Colace?

Colace is a stool softener. It makes bowel movements softer and easier to pass.

Colace is used to treat or prevent occasional constipation, and to reduce pain or rectal damage caused by hard stools or by straining during bowel movements.

Colace may also be used for purposes not listed in this medication guide.

Warnings

You should not use Colace if you have a blockage in your intestines.

Do not use Colace while you are sick with nausea, vomiting, or severe stomach pain.

You should not use docusate if you also use mineral oil, unless your doctor tells you to.

Before taking this medicine

You should not use Colace if you are allergic to docusate.

Ask a doctor or pharmacist if this medicine is safe to use if you have:

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not give this medicine to a child without medical advice.

How should I use Colace?

Use Colace exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water. Drink plenty of liquids while you are taking this medicine.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Colace generally produces bowel movement in 12 to 72 hours. Call your doctor if your symptoms do not improve after 72 hours.

You should not use this medicine for longer than 1 week, unless your doctor tells you to. Call your doctor if your symptoms do not improve, or if you have not had a bowel movement within 1 to 3 days. Overuse of a stool softener can lead to serious medical problems.

Store at room temperature away from moisture, light, and heat. Do not freeze liquid medicine.

Dosing information

Usual Adult Dose for Constipation:

50 to 300 mg daily divided in 1 to 4 doses each day.

Usual Pediatric Dose for Constipation:

Less than 2 years: Check with your doctor.

2 to 12 years: 50 to 150 mg daily divided in 1 to 4 doses each day.

What happens if I miss a dose?

Since Colace is used when needed, you may not be on a dosing schedule. Skip any missed dose if it’s almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Colace?

Avoid using mineral oil, unless told to do so by a doctor.

Colace side effects

Get emergency medical help if you have signs of an allergic reaction to Colace : hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if:

• you have rectal bleeding;

• no bowel movement occurs after using a laxative;

• you need to use a stool softener for more than 1 week; or

• if a rash occurs.

Less serious Colace side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Colace?

Other drugs may interact with docusate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

Any drug that is classified as an “opioid” can cause constipation. Examples of commonly prescribed opioids that may cause this side effect include morphine, tramadol, fentanyl, methadone, hydrocodone, codeine and oxycodone. Continue reading

More FAQ

• What is the maximum dosage for Colace stool softener at one time?

References

1. Colace Product Label

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Colace only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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Copyright 1996-2023 Cerner Multum, Inc. Version: 5.01.

E952 – Sodium cyclamate | Additives no

Other additive names (synonyms)

sodium cyclamate, sodium cyclamate, cyclamic acid and its sodium, potassium and calcium salts, sodium cyclamate, cyclamic acid and Ca salts

Additive E952, better known as sodium cyclamate, is used in the food industry as a sweetener. This chemical is ten times sweeter than sugar. Some people find foods with sodium cyclamate unpleasant to the taste.

Chemically speaking, E952 is cyclamic acid and its sodium, potassium and calcium salts. The chemical formula of sodium cyclamate is C ₆ H ₁₂ S ₃ NNaO.

Additive E952 is prepared by sulfonation from cyclohexylamine. The cyclamate formation reaction is achieved by reacting cyclohexylamine with sulfamic acid or sulfur trioxide.

Cyclamate was discovered in 1937 at the University of Illinois by graduate student Michael Sveda. The graduate student worked in the laboratory for the synthesis of an antipyretic agent. He accidentally dipped a cigarette into the preparation, and when he took it back into his mouth, he discovered the sweet taste of cyclamate.

The patent for cyclamate was acquired by DuPont but later sold to Abbott Laboratories, which did the necessary research and introduced the new drug in 1950. Initially, Abbott intended to use cyclamate to mask the bitterness of certain drugs, such as antibiotics and pentobarbital. In 1958, cyclamate was recognized as a safe food supplement in the United States. Cyclamate was sold in tablet form for use by diabetic patients as an alternative to sugar.

However, at 1966 studies have shown that some intestinal bacteria can break down cyclamate to form cyclohexylamine, which in turn can be toxic to some living organisms. Further studies in rats in 1969 showed that cyclamate promotes the development of bladder cancer. Following these studies, the FDA banned the use of cyclamate in the US. Since then, Abbott has repeatedly petitioned the FDA to lift the ban on cyclamate, arguing that it is safe. However, to date, the addition of E952 remains banned for use in the US food industry.

Most experts now believe that the E952 supplement does not directly cause cancer, but may increase the effect of other carcinogens.

Additive E952 is not absorbed by the body of most people and animals and is excreted in the urine. The safe daily dose of sodium cyclamate is 10 mg per 1 kg of body weight. At the same time, a number of people in the intestines have bacteria that process sodium cyclamate with the formation of conditionally teratogenic metabolites. Therefore, the use of products with the addition of E9 is not recommended.52 pregnant women.

The most commonly used mixture in food products is 10 parts cyclamate and 1 part saccharin. Often cyclamate is used in low-calorie drinks, diabetic products. Sweetener E952 is stable when heated, which allows it to be used in confectionery and hot instant drinks.

Despite the potential health risks, E952 is now approved for use as a sweetener in more than 55 countries. Cyclamate is included in the list of permitted food additives in Ukraine. In the Russian Federation, sodium cyclamate was excluded from the list of approved food additives on December 23, 2010.

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