Cozaar medicine: Drug Database | Medication Decision Support
Cozaar Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Warnings:
This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor right away.
Warnings:
This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor right away.
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Uses
Losartan is used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes.
It is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heart. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Losartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by relaxing blood vessels so that blood can flow more easily.
How to use Cozaar
Read the Patient Information Leaflet if available from your pharmacist before you start taking losartan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once daily. The dosage is based on your medical condition and response to treatment.
If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
Use this medication regularly to get the most benefit from it.
To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.
Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings increase).
Side Effects
Dizziness or lightheadedness may occur as your body adjusts to the medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: fainting, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat).
Although losartan may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking losartan. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before taking losartan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, dehydration, high level of potassium in the blood.
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
This medication may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using losartan. Losartan may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. (See also Warning section.)
It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Interactions
See also Precautions section.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Some products that may interact with this drug include: aliskiren, lithium, drugs that may increase the level of potassium in the blood (such as sparsentan, ACE inhibitors including benazepril/lisinopril, birth control pills containing drospirenone).
Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).
Does Cozaar interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, fainting.
Do not share this medication with others.
Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.
Lab and/or medical tests (such as kidney function, potassium levels) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.
Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure, and share the results with your doctor.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Store tablets at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Store the suspension in the refrigerator. Do not freeze. Discard any unused suspension after 4 weeks.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Images
Cozaar 100 mg tablet
Color: whiteShape: teardropImprint: 960
This medicine is a white, teardrop, film-coated, tablet imprinted with “960”.
Cozaar 50 mg tablet
Color: whiteShape: ovalImprint: 952
This medicine is a white, teardrop, film-coated, tablet imprinted with “960”.
Cozaar 100 mg tablet
Color: dark greenShape: teardropImprint: 960 MRK
This medicine is a white, teardrop, film-coated, tablet imprinted with “960”.
Cozaar 25 mg tablet
Color: whiteShape: ovalImprint: 951
This medicine is a white, teardrop, film-coated, tablet imprinted with “960”.
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Selected from data included with permission and copyrighted by First Databank, Inc.
This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Today on WebMD
Cozaar (Losartan potassium) Drug / Medicine Information
NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia.
Losartan potassium
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about COZAAR.
It does not contain all
the available information. It does not take the place of talking to your doctor or
pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
COZAAR against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What COZAAR is used for
COZAAR lowers high blood pressure, which doctors call hypertension.
COZAAR is also used to slow the progression of kidney disease in people who have type
2 diabetes mellitus (also known as non-insulin dependent diabetes) with protein in
their urine (which doctors call proteinuria).
Hypertension:
Everyone has blood pressure. This pressure helps get your blood all around your body.
Your blood pressure may be different at different times of the day, depending on how
busy or worried you are.
You have hypertension (high blood pressure) when your blood
pressure stays high, even when you are calm and relaxed.
There are usually no symptoms of hypertension. The only way of knowing that you have
hypertension is to have your blood pressure checked on a regular basis. If high blood
pressure is not treated it can lead to serious health problems. You may feel fine
and have no symptoms, but eventually hypertension can cause stroke, heart disease
or kidney failure. COZAAR helps to lower your blood pressure.
Type 2 Diabetes Mellitus:
Type 2 diabetes mellitus is a condition in which the body’s cells do not respond to
the effects of insulin or too little insulin is produced, resulting in an elevated
blood (sugar) level, known as hyperglycaemia.
Insulin maintains the appropriate level of glucose in the blood by transporting it
into the body’s cells so that they can produce energy or store glucose until it’s
needed.
Hyperglycaemia can lead to serious problems with your heart, eyes, circulation or
kidneys. When kidney damage occurs, its ability to filter blood is reduced, and proteins
in the blood are lost in the urine. This may eventually lead to kidney failure.
In people who have type 2 diabetes mellitus with protein in their urine, COZAAR helps
to slow the worsening of kidney disease and reduce the need for dialysis or kidney
transplantation.
How it works
COZAAR belongs to a group of medicines, called angiotensin II receptor antagonists.
It works to lower your blood pressure by relaxing your blood vessels. In addition,
COZAAR slows the progression of kidney disease in people who have type 2 diabetes
mellitus with protein in the urine.
COZAAR is not addictive.
Before you take COZAAR
When you must not take it
Do not take COZAAR if:
you are pregnant or breast-feeding
The use of COZAAR while you are pregnant or breast-feeding is not recommended.
Your
baby may absorb this medicine in the womb. COZAAR can cause harm or death to an unborn
baby. Talk to your doctor about other ways to lower your blood pressure if you plan
to become pregnant. If you get pregnant while taking COZAAR tell your doctor right
away. It is not known whether COZAAR passes into breast milk, therefore it is not
recommended to be taken while you are breast-feeding.
you have an allergy to COZAAR or any of the ingredients listed at the end of this
leaflet
you have diabetes and are taking a medicine called aliskiren to reduce blood pressure.
the packaging is torn or shows signs of tampering
the expiry date on the pack has passed.
If you take this medicine after the expiry date has passed, it may not work.
If you are not sure whether you should start taking COZAAR, talk to your doctor.
Do not give COZAAR to a child.
There is no experience with the use of COZAAR in children.
Before you start to take it
Tell your doctor if:
1. you intend to become pregnant or plan to breast-feed
COZAAR should not be used during pregnancy or while breast-feeding.
2. you are taking other medicines that may increase serum potassium (see Taking other
medicines).
3. you have any medical conditions, especially the following:
kidney disease
liver problems or have had these in the past.
4. you have recently had excessive vomiting or diarrhoea
5. you have any allergies to any other medicines or any other substances, such as foods,
preservatives or dyes.
If you have not told your doctor about any of the above, tell them before you take
any COZAAR.
Taking other medicines
Tell your doctor if you are taking any other medicines, including medicines that you
buy without a prescription from your pharmacy, supermarket or health food shop.
Some medicines or substances and COZAAR may interfere with each other. These include:
Other blood pressure medicines
diuretic tablets, also called fluid or water tablets, including potassium-sparing
diuretics
potassium tablets
potassium-containing salt substitutes
other medicines that may increase serum potassium (e.g., trimethoprim-containing products).
medicines used to relieve pain, swelling, and other symptoms of inflammation, for
example, indomethacin.
lithium (a medicine used to treat mood swings and some types of depressions)
grapefruit juice (which should be avoided while taking COZAAR)
These medicines may have an additive effect with COZAAR in lowering your blood pressure,
or may affect how well it works, or may lead to increases in potassium in your blood.
You may need to take different amounts of your medicine, or you may need to take different
medicines.
Your doctor or pharmacist has more information on medicines to be careful with or
avoid while taking COZAAR.
How to take COZAAR
How much to take
Your doctor will tell you how many tablets you need to take each day. This depends
on your condition and whether you are taking other medicines. Take COZAAR only when
prescribed by your doctor.
For high blood pressure:
For most patients, the usual starting dose is one 50 mg tablet taken once a day.
Some patients may need a lower starting dose. The dose may need to be increased depending
on your blood pressure. Most patients take between 25 to 100 mg each day, taken as
a single dose or in divided doses.
For type 2 diabetes mellitus with protein in the urine:
The usual starting dose is one 50 mg tablet taken once a day. The dose may be increased
to 100 mg once a day depending on your blood pressure.
Follow all directions given to you by your doctor carefully. They may differ from
the information contained in this leaflet.
If you do not understand the instructions on the box, ask your doctor or pharmacist
for help.
When to take it
Take your COZAAR at about the same time each day.
Taking your tablet(s) at the same time each day will have the best effect. It will
also help you remember when to take the tablets.
Swallow COZAAR with a glass of water.
It does not matter whether you take COZAAR before or after food.
How long to take it
COZAAR helps control your high blood pressure, but does not cure it. Therefore COZAAR
must be taken every day. Continue taking COZAAR for as long as your doctor prescribes.
If you forget to take it
If it is almost time for your next dose, skip the dose you missed and take your next
dose when you are meant to.
Otherwise, take it as soon as you remember, and then
go back to taking your tablet(s) as you would normally.
If you are not sure whether to skip the dose, talk to your doctor or pharmacist.
Do not take a double dose to make up for the dose that you missed.
If you have trouble remembering to take your tablets, ask your pharmacist for some
hints.
If you take too much (overdose)
Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26),
or go to accident and emergency at your nearest hospital, if you think that you or
anyone else may have taken too much COZAAR. Do this even if there are no signs of
discomfort or poisoning.
If you take too many tablets, you will probably feel light-headed or dizzy.
While you are using COZAAR
Things you must do
If you become pregnant while taking COZAAR, tell your doctor immediately.
Your doctor needs to know immediately so that COZAAR can be replaced by another medicine.
Have your blood pressure checked when your doctor says, to make sure COZAAR is working.
If you are about to be started on any new medicine, tell your doctor and pharmacist
that you are taking COZAAR.
If you feel light-headed, dizzy or faint, get up slowly when getting out of bed or
standing up.
You may feel light-headed or dizzy while taking COZAAR, especially if you are also
taking a diuretic (fluid tablet). This may become worse if you stand up quickly as
your blood pressure may fall. Standing up slowly, especially when you get up from
bed or chairs, will help your body get used to the change in position and blood pressure.
This problem is not common. If it occurs and gets worse or continues, talk to your
doctor.
If you plan to have surgery (even at the dentist) that needs a general anaesthetic,
tell your doctor or dentist that you are taking COZAAR.
Make sure you drink enough water during exercise and hot weather when you are taking
COZAAR, especially if you sweat a lot.
If you do not drink enough water while taking COZAAR, you may faint or feel light-headed
or sick. This is because your body doesn’t have enough fluid and your blood pressure
is low. If you continue to feel unwell, tell your doctor.
If you have excessive vomiting and/or diarrhoea while taking COZAAR, tell your doctor.
This can also mean that you are losing too much water and your blood pressure may
become too low.
If your doctor has prescribed potassium tablets for you, continue taking them.
COZAAR contains a very small amount of potassium, but this does not replace any potassium
tablets that you may be taking.
Go to your doctor regularly for a check-up.
Your doctor may occasionally do a blood test to check your potassium level in the
blood and to see how your kidneys are working.
Things you must not do
Do not give COZAAR to anyone else, even if they have the same condition as you.
Things to be careful of
Be careful driving or operating machinery until you know how COZAAR affects you.
As with many other medicines used to treat high blood pressure, COZAAR may cause dizziness
or light-headedness in some people. Make sure you know how you react to COZAAR before
you drive a car, operate machinery, or do anything else that could be dangerous if
you are dizzy or light-headed. If you drink alcohol, dizziness or light-headedness
may be worse.
Things that would be helpful for your blood pressure
Some self-help measures suggested below may help your condition. Talk to your doctor
or pharmacist about these measures and for more information.
Alcohol –
your doctor may advise you to limit your alcohol intake.
Diet –
eat a healthy diet which includes plenty of fresh vegetables, fruit, bread, cereals
and fish.
Also eat less fat and sugar.
Exercise –
regular exercise helps to reduce blood pressure and helps the heart get fitter, but
it is important not to overdo it. Walking is good exercise, but try to find a route
that is fairly flat. Before starting any exercise, ask your doctor about the best
kind of programme for you.
Salt –
your doctor may advise you to watch the amount of salt in your diet. To reduce your
salt intake you should avoid using salt in cooking or at the table.
Smoking –
your doctor may advise you to stop smoking or at least cut down.
Weight –
your doctor may suggest losing some weight to help lower your blood pressure and help
lessen the amount of work your heart has to do. Some people may need a dietician’s
help to lose weight.
Side Effects
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking COZAAR.
COZAAR helps most people with high blood pressure, but it may have unwanted side effects
in a few people. All medicines can have side effects. Sometimes they are serious,
most of the time they are not. You may need medical treatment if you get some of
the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you:
dizziness
lightheadedness
tiredness or weakness
spinning sensation
generally feeling unwell
increased sensitivity of the skin to sun
inability to get or maintain an erection
These are the common side effects of COZAAR. For the most part these have been mild.
Also, tell your doctor if you develop cough.
Tell your doctor immediately if you notice any of the following:
skin rash, itchiness
aching muscles, not caused by exercise
signs of anaemia, such as tiredness, being short of breath, and looking pale
bleeding or bruising more easily than normal
These may be serious side effects.
Skin rash and itchiness may be symptoms of an
allergic reaction. You may need medical attention. These side effects are not common.
If any of the following happen, stop taking COZAAR and tell your doctor immediately
or go to accident and emergency at your nearest hospital:
swelling of the face, lips, mouth, tongue or throat which may cause difficulty in
swallowing or breathing
severe and sudden onset of pinkish, itchy swellings on the skin, also called hives
or nettlerash
These are serious side effects. If you have them, you may have had a serious allergic
reaction to COZAAR. You may need urgent medical attention or hospitalisation. These
side effects are rare.
Other side effects not listed above may also occur in some patients. Tell your doctor
if you notice any other effects.
Do not be alarmed by this list of possible side effects. You may not experience any
of them.
After using COZAAR
Storage
Keep your tablets in the blister pack until it is time to take them.
If you take the tablets out the blister pack they may not keep well.
Keep it in a cool dry place where the temperature stays below 30°C. Do not store it
or any other medicine in the bathroom or near a sink.
Do not leave it in the car or on window sills.
Heat and dampness can destroy some medicines.
Keep it where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
Disposal
If your doctor tells you to stop taking COZAAR or the tablets have passed their expiry
date, ask your pharmacist what to do with any that are left over.
Product description
What it looks like
COZAAR comes in one type of tablet:
COZAAR 50 mg – white, oval shaped tablet with “952” marked on one side and scored
on the other side.
A pack of COZAAR contains 30 tablets.
Ingredients
Active ingredient:
COZAAR 50 mg – losartan potassium 50 mg per tablet
Inactive ingredients:
microcrystalline cellulose
lactose monohydrate
pregelatinised maize starch
magnesium stearate
hyprolose
hypromellose
titanium dioxide
carnauba wax
COZAAR does not contain gluten, sucrose, tartrazine or any other azo dyes.
Supplier
COZAAR is supplied in Australia by:
Organon Pharma Pty Limited
Building A, 26 Talavera Road,
Macquarie Park, NSW 2113 Australia
This leaflet was prepared in April 2022.
Australian Register Number:
50 mg – AUST R 54809
© 2021 Organon group of companies. All rights reserved.
S-WPPI-OG0954-T-102021
RCN 100000561-AU
💊 Composition of Cozaar ✅ Use of Cozaar Keep for yourself Search for analogues Interaction Description of the active ingredients of the preparation cozaar The scientific information provided is general and cannot be used to make decisions. Update date: 2020.11.07 Marketing authorization holder: MERCK SHARP & DOHME, B. Made:MERCK SHARP & DOHME (UK) ATX code: C09CA01 (Losartan) Active substance: Rec.INN registered by WHO Dosage form
Release form, packaging and composition |
film coated, 50 mg: 14 or 28 pcs. (408)
V.
50 Hyprolose (from 0.3% silicon dioxide) – 1.8 mg, hypromellose – 1.8 mg, titanium dioxide – 0.9 mg, carnauba wax – 0.05 mg.
| I10 | Essential [primary] hypertension |
| I50.0 | Congestive heart failure |
N08. 3 | Glomerular lesions in diabetes mellitus |
Dosing regimen
The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.
The average oral dose is 50 mg 1 time / day. If necessary, the dose can be reduced to 25 mg / day or increased to 100 mg / day, in the latter case it can be used 2 times / day.
Side effects
From the side of the cardiovascular system: dizziness, orthostatic hypotension.
From the side of metabolism: hyperkalemia.
Allergic reactions: angioedema (including swelling of the face, lips, pharynx and/or tongue), urticaria.
From the digestive system: diarrhea, increased ALT activity.
From the side of the central nervous system: headache.
Dermatological reactions: itching.
Other: kidney dysfunction, myalgia.
Contraindications for use
Pregnancy, lactation, children and adolescents under 18 years of age, hypersensitivity to losartan.
Use in pregnancy and lactation
Contraindicated in pregnancy and lactation.
Use in hepatic impairment
In patients with a history of liver disease, low doses of losartan should be used. With cirrhosis of the liver, the concentration of losartan in the blood plasma increases significantly.
Use in impaired renal function
Renal impairment may require dose reduction of losartan.
Use in children
The safety and efficacy of losartan in children have not been established.
Use in elderly patients
In elderly patients during the treatment period, the level of potassium in the blood should be regularly monitored.
Precautions
Use with caution in arterial hypotension, decreased BCC, fluid and electrolyte imbalance, bilateral renal artery stenosis or arterial stenosis of a solitary kidney, in renal / hepatic insufficiency
Patients who are deficient in fluid and/or sodium should have their fluid and electrolyte disturbances corrected before starting treatment or use a lower initial dose.
In patients with dehydration (eg, treated with high dose diuretics), symptomatic hypotension may occur at the start of treatment with losartan.
Renal impairment may require dose reduction of losartan.
In patients with a history of liver disease, losartan should be used at low doses. With cirrhosis of the liver, the concentration of losartan in the blood plasma increases significantly.
During the period of treatment, the level of potassium in the blood should be regularly monitored, especially in elderly patients, with impaired renal function.
Concomitant use of losartan with potassium-sparing diuretics should be avoided.
The safety and efficacy of losartan in children have not been established.
Drug interactions
When used simultaneously with diuretics in high doses, arterial hypotension is possible.
When used simultaneously with potassium preparations, potassium-sparing diuretics, the risk of developing hyperkalemia increases.
Co-administration with indomethacin may reduce the effectiveness of losartan.
There is a report of the development of lithium intoxication with simultaneous use with lithium carbonate.
When used simultaneously with orlistat, the antihypertensive effect of losartan decreases, which can lead to a significant increase in blood pressure, the development of a hypertensive crisis.
With simultaneous use with rifampicin, the clearance of losartan increases and its effectiveness decreases.
Keep
If you want to place a link to the description of this drug – use this code
Cozaar .
Description of the drug in the reference book Vidal.
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