What they are and how to manage them

Cymbalta (duloxetine) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat the following conditions in adults:

• fibromyalgia
• chronic musculoskeletal pain (pain affecting the bones, joints, muscles, ligament, or tendons)
• pain from diabetic neuropathy
• generalized anxiety disorder
• major depressive disorder (commonly called depression)

The FDA has approved it to treat the following conditions in certain children:

• generalized anxiety disorder in children ages 7 years and older
• fibromyalgia in children ages 13 years and older

Here are some fast facts about Cymbalta:

• Active ingredient: duloxetine
• Drug class: serotonin-norepinephrine reuptake inhibitor (SNRI)
• Drug form: delayed-release capsule
• FDA approval year: 2004

As with other drugs, Cymbalta can cause side effects. Read on to learn about potential common, mild, and serious side effects. For a general overview of Cymbalta, including details about its uses, see this article.

Cymbalta can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported by people who took Cymbalta in clinical trials:

• loss of appetite
• drowsiness or fatigue
• dry mouth
• constipation*
• nausea*

* For more information about this side effect, see “Side effect specifics” below.

Mild side effects can occur with Cymbalta use. This list doesn’t include all possible mild side effects of the drug. For more information, you can refer to Cymbalta’s prescribing information.

Mild side effects that have been reported with Cymbalta include:

• abdominal pain (stomach pain)
• diarrhea
• dizziness
• dry mouth
• drowsiness or fatigue
• excessive sweating
• insomnia
• heart palpitations
• loss of appetite
• nausea*
• headache*
• sexual side effects*
• constipation*
• mild allergic reaction*

These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you develop a side effect while taking Cymbalta and want to tell the FDA about it, visit MedWatch.

* For more information about this side effect, see “Side effect specifics” below.

Cymbalta may cause serious side effects. The list below may not include all possible serious side effects of the drug. For more information, you can refer to Cymbalta’s prescribing information.

If you develop serious side effects while taking Cymbalta, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects that have been reported and their symptoms include:

• Angle-closure glaucoma. Symptoms can include:
  • blurred vision
  • eye pain
  • seeing halos or rings around lights
  • severe headache
• Hyponatremia (low blood sodium levels). Symptoms can include:
  • confusion
  • difficulty with memory
  • trouble concentrating
  • muscle weakness
• High blood pressure, which does not typically have symptoms.
• Liver damage. Symptoms can include:
  • dark-colored urine
  • fatigue
  • itchiness
  • jaundice
• Orthostatic hypotension (low blood pressure when you stand up). Symptoms can include:
  • dizziness, which can lead to fainting or falls
  • blurred vision
• Seizure. Symptoms can include:
  • tingling in the hands or feet
  • loss of taste, smell, or hearing
  • convulsions or spasms
• Serotonin syndrome (too much serotonin in the body), which can be life threatening. Symptoms can include:
  • agitation
  • delirium
  • dizziness
  • fast heart rate
  • fever
  • nausea, vomiting, or diarrhea
  • seizure
  • sweating or flushing
  • tremors
• Severe skin reactions, including Stevens-Johnson syndrome. Symptoms can include:
  • blisters
  • hives
  • mouth sores
  • peeling rash
• Difficulty urinating. Symptoms can include:
  • decreased urine flow
  • inability to urinate
• Withdrawal symptoms, especially when stopping the drug suddenly. Symptoms can include:
  • atypical sensations, such as burning or prickling
  • anxiety or irritability
  • excessive sweating
  • nausea, vomiting, or diarrhea
  • drowsiness or fatigue
• Risk of suicidal thoughts and behaviors.*
• Severe allergic reaction. †

* Cymbalta has a boxed warning for this side effect. This is a serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section below.
† An allergic reaction is possible after taking Cymbalta. However, it’s not clear whether this side effect occurred in clinical trials. To learn more, see the “Side effect specifics” section below.

Cymbalta is approved to treat generalized anxiety disorder in children ages 7 years and older. It’s also approved to treat fibromyalgia in children ages 13 years and older. The list below may not include all possible side effects of Cymbalta in children. For more information, see Cymbalta’s prescribing information.

In clinical trials of Cymbalta, the following side effects were commonly reported in children:

• loss of appetite
• decreased weight
• diarrhea
• fatigue
• vomiting
• nausea*

In addition, Cymbalta has a boxed warning for the risk of suicidal thoughts and behaviors in children. For more information, see the “Side effect specifics” section below.

If you have questions about Cymbalta and its possible side effects in children, speak with your child’s doctor or pharmacist.

* For more information about this side effect, see “Side effect specifics” below.

Cymbalta may cause several side effects. Here are some frequently asked questions about the drug’s side effects and their answers.

Is weight gain a side effect of Cymbalta?

No, weight gain wasn’t reported in Cymbalta’s clinical trials. However, weight gain can result from depression or inactivity due to other chronic medical conditions.

Cymbalta treats depression and other conditions that can result in inactivity due to pain or fatigue, such as fibromyalgia and diabetic neuropathy (nerve pain). So, it’s important to discuss weight changes with your doctor.

If you have concerns about weight gain with Cymbalta, talk with your doctor. They can help determine potential causes and ways to manage it.

If I stop taking Cymbalta, will I experience withdrawal symptoms?

Stopping Cymbalta treatment may cause a group of withdrawal symptoms called discontinuation syndrome.

Discontinuation syndrome can happen any time you stop taking an antidepressant. However, it’s more likely when you stop it suddenly. Due to this risk, doctors typically do not recommend stopping cold turkey. Instead, doctors usually recommend gradually reducing the dose of the drug.

Talk with your doctor if you are interested in stopping treatment with Cymbalta. Do not stop taking the drug before talking with your doctor about how to do it safely. When stopping treatment, report any unusual symptoms to your doctor, such as burning or tingling, dizziness, or brain zaps.

Can Cymbalta cause long-term side effects?

Some serious side effects of Cymbalta, such as liver damage and angle-closure glaucoma, may be long term. Contact your doctor right away if you experience any serious side effects.

Most mild side effects of Cymbalta are temporary, lasting a few days to weeks. However, be sure to talk with your doctor or pharmacist if side effects last longer, bother you, or become severe.

Does Cymbalta cause different side effects in women vs. men?

In clinical trials of Cymbalta, males* and females* reported some differences in side effects.

Certain sexual side effects were reported in both males and females, including a decreased libido (sexual desire) and a delay or lack of orgasm. However, males also reported erectile dysfunction (ED) and delayed ejaculation. Additionally, sexual side effects were more common in males than in females.

For more information about sexual side effects with Cymbalta, view the “Side effects specifics” section below.

If you have questions or concerns about Cymbalta’s side effects, talk with your doctor or pharmacist.

* Sex and gender exist on spectrums. Use of the terms “female” and “male” in this article refers to sex assigned at birth.

Learn more about some of the side effects that Cymbalta may cause. To find out how often side effects occurred in clinical trials, see Cymbalta’s prescribing information.

Risk of suicidal thoughts and behaviors

Cymbalta has a boxed warning for the risk of suicidal thoughts and behaviors. This is a serious warning from the Food and Drug Administration (FDA).

Antidepressants, such as Cymbalta, can increase the risk of suicidal thoughts and behaviors in people with depression and other mental health conditions. Cymbalta may increase this risk in children, adolescents, and young adults up to 24 years old.

In clinical trials, this increased risk was not reported in adults older than 24 years. The risk of suicidal thoughts and behaviors may actually be lower in adults 65 years and older.

What you can do

Due to the boxed warning, doctors typically monitor closely for signs of suicidal thoughts or behaviors. Signs to watch for include changes in thoughts, feelings, mood, or behavior. If you notice any of these symptoms, contact your doctor immediately.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

• Ask the tough question: “Are you considering suicide?”
• Listen to the person without judgment.
• Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
• Stay with the person until professional help arrives.
• Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Click here for more links and local resources.

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Sexual side effects

Cymbalta may cause sexual side effects in some people. These can include erectile dysfunction (ED), delayed ejaculation, a delay or lack of orgasm, and decreased libido (sexual desire).

However, it’s important to know that some of the conditions Cymbalta treats can also cause sexual dysfunction. This can make it hard to tell whether it’s the condition or the drug causing the side effect.

In clinical trials of Cymbalta, males* taking Cymbalta reported more sexual side effects than those taking a placebo. (In these studies, a placebo was a pill without an active ingredient.) In females,* the same sexual side effects occurred with both Cymbalta and the placebo.

What you can do

If you have questions or concerns about sexual side effects, talk with your doctor. Tell your doctor about any changes in sexual function during treatment with Cymbalta. They can suggest ways to manage or treat these concerns.

* Sex and gender exist on spectrums. Use of the terms “female” and “male” in this article refers to sex assigned at birth.

Nausea

Nausea was the most common side effect reported in clinical trials of Cymbalta. It was also the most common reason people stopped taking the drug.

It’s important to let your doctor know about any nausea you experience. This can be a symptom of other serious side effects, such as serotonin syndrome (too much serotonin in the body) and withdrawal symptoms.

What you can do

Contact your doctor if you have nausea that persists or becomes severe. They can help you find ways to manage this side effect.

Tips to help relieve nausea include:

• avoiding fatty, fried, greasy, spicy, or heavily seasoned foods
• consuming several small snacks during the day instead of three large meals
• avoiding from strong aromas and smells
• taking sips of liquid or sucking on ice chips often during the day

Headache

Headache was another common side effect reported in clinical trials of Cymbalta. However, this side effect occurred only slightly more in people taking Cymbalta. So, it’s difficult to tell whether or not Cymbalta caused these headaches.

That said, headache can be a symptom of other serious side effects, such as angle-closure glaucoma and discontinuation syndrome.

What you can do

Contact your doctor if you have headaches that persist or become severe. They can suggest ways to manage this problem, such as taking over-the-counter (OTC) pain relievers. These pain relievers can include Advil (ibuprofen) or Aleve (naproxen). For a severe headache with other symptoms that concern you, seek medical care right away.

Constipation

Constipation was also a common side effect reported in Cymbalta’s clinical trials. However, it wasn’t one of the reported reasons that people stopped taking the drug.

What you can do

Contact your doctor if constipation becomes long lasting or severe. They can recommend ways to manage this side effect, including certain OTC remedies. They may suggest a stool softener, such as Colace (docusate), or a laxative, such as Dulcolax (bisacodyl).

Tips to help relieve and prevent constipation include:

• drinking more water
• increasing the amount of fiber in your diet
• staying physically active
• taking a probiotic supplement or eating probiotic foods

Allergic reaction

As with most drugs, Cymbalta can cause an allergic reaction in some people. However, it’s not clear whether this side effect occurred in clinical trials.

Symptoms can be mild or serious and can include:

• skin rash
• itching
• flushing
• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

What you can do

For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and determine whether you should keep taking Cymbalta. However, if your symptoms are serious and you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Cymbalta comes with several warnings, including a boxed warning.

Boxed warning: Risk of suicidal thoughts and behaviors

This drug has a boxed warning for the risk of suicidal thoughts and behaviors. This is a serious warning from the Food and Drug Administration (FDA). For details, see the “Side effect specifics” section above.

Other precautions

Be sure to talk with your doctor about your health history before you take Cymbalta. This drug may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. These are considered drug-condition or drug-factor interactions. The conditions and factors to consider include:

Activation of mania. Cymbalta may trigger a manic or hypomanic episode in people with depression. Symptoms of these episodes may include euphoria, irritability, or racing thoughts. The risk may be higher if you have bipolar disorder or risk factors for the condition. Tell your doctor if you have a history of bipolar disorder before starting Cymbalta. They can advise whether this medication is safe for your condition.

Bleeding problems. Cymbalta can increase the risk of bleeding. This risk may be higher if you take other drugs that affect bleeding, such as aspirin, warfarin, or other anticoagulants. Certain clotting disorders can also increase your risk of this side effect. These disorders can include hemophilia, von Willebrand’s disease, or a low platelet count. If you take any of these drugs or have a history of clotting disorders, talk with your doctor before starting Cymbalta. They can advise whether this medication is safe for your condition.

Diabetes. In people with diabetes, Cymbalta can make it harder to manage blood sugar levels. If you have diabetes, tell your doctor before starting Cymbalta. They can suggest any necessary changes in how you monitor your blood sugar or manage your diabetes.

High blood pressure. Cymbalta may cause increases in blood pressure. Your doctor will check your blood pressure before prescribing the drug and during treatment. If you already have high blood pressure, taking Cymbalta may worsen this condition. In this case, your doctor will likely want to treat your high blood pressure before prescribing Cymbalta.

Your doctor may also recommend that you check your blood pressure at home between appointments. If you develop high blood pressure while taking Cymbalta, let your doctor know. They can advise whether this treatment is still safe for your condition.

Liver or kidney problems. Cymbalta isn’t recommended for people with severe liver or kidney problems, such as liver disease or kidney disease. Taking this drug may worsen these conditions. If you have liver or kidney problems, talk with your doctor before starting Cymbalta. They may recommend other treatment options for your condition.

Seizure. Cymbalta may cause seizure, but it hasn’t been studied in people with seizure disorders. Because of this, it’s not known if the drug is safe for people with these conditions to take. If you have a seizure disorder or history of seizures, tell your doctor before starting Cymbalta. They may recommend other treatment options for your condition.

Slow stomach emptying. Cymbalta has a coating that protects it from stomach acid. When the stomach empties slowly, the stomach acid can break down this coating. This may cause Cymbalta to be less effective. If you have diabetes or another condition that could affect stomach emptying, tell your doctor before starting Cymbalta.

Allergic reaction. If you’ve had an allergic reaction to Cymbalta or any of its ingredients, your doctor will likely not prescribe Cymbalta. Ask your doctor what other medications may be better options for you.

Alcohol with Cymbalta

Cymbalta and heavy alcohol consumption may interact and cause severe liver damage. Your doctor will likely recommend avoiding heavy alcohol consumption while taking Cymbalta.

Ask your doctor how much alcohol, if any, is safe to consume while taking Cymbalta.

Pregnancy and breastfeeding while taking Cymbalta

Cymbalta may cause harm to a developing fetus. However, more research is necessary to determine if there is a clear risk of congenital anomalies (commonly known as birth defects). Clinical trials of Cymbalta reported an increased risk of postpartum hemorrhage (severe bleeding after childbirth).

Tell your doctor if you become pregnant or become pregnant while taking Cymbalta. Together, you can discuss the risks and benefits of taking the drug during pregnancy. They can also help you explore other treatment options.

Cymbalta passes into human breast milk and can affect a child who is breastfeeding. However, it isn’t known to cause serious side effects. Side effects reported in infants who were breastfeeding included drowsiness, limited feeding, and trouble gaining weight.

Talk with your doctor if you’re breastfeeding or plan to breastfeed. Together, you can discuss the risks and benefits of breastfeeding while taking Cymbalta. They can also help you explore other treatment options.

Cymbalta has some common side effects that are usually mild and temporary. However, serious side effects are possible. If you’d like to learn more about Cymbalta, talk with your doctor or pharmacist. They can help answer any questions you have about side effects from taking the drug.

Besides talking with your doctor, you can do some research on your own. These articles might help:

• More information about Cymbalta. For details about other aspects of Cymbalta, refer to this article.
• Drug comparison. Learn how Cymbalta compares with Lexapro and Effexor XR.
• Dosage. For information about the dosage of Cymbalta, view this article.
• Interactions. To find out about Cymbalta’s interactions, see this article.
• A look at Cymbalta’s uses. To learn more about your condition, see our:
  • anxiety hub
  • diabetes hub
  • mental health hub
  • list of fibromyalgia articles

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

What They Are and How to Manage Them

Cymbalta (duloxetine) is a prescription drug that’s used to treat certain conditions, including depression. The drug can cause side effects that range from mild to serious, including some sexual side effects.

Cymbalta is used as a long-term treatment for several different conditions in adults, including:

• major depressive disorder
• generalized anxiety disorder (GAD)
• pain caused by diabetic neuropathy (nerve damage caused by diabetes)
• fibromyalgia (a condition that causes pain throughout the body)
• long-term musculoskeletal pain (pain in the bones, muscles, tendons, ligaments, and nerves)

Cymbalta is also approved to treat GAD and fibromyalgia in certain children.

The active ingredient in Cymbalta is duloxetine. (An active ingredient is what makes a drug work.) The drug comes as capsules that you swallow.

Keep reading to learn about the common, mild, and serious side effects that Cymbalta can cause. For a general overview of the drug, including details about its uses, see this article.

Some people may experience mild or serious side effects during Cymbalta treatment. Some side effects are more common than others.

Cymbalta’s more common side effects include:

• fatigue (lack of energy)
• nausea
• constipation
• reduced appetite
• sweating more than usual*
• dizziness

* To learn more about this side effect, see “Side effects explained” below.

Mild side effects have been reported with Cymbalta, many of which are also more common side effects of the drug. Cymbalta’s mild side effects include:

• sleepiness
• fatigue (lack of energy)
• nausea
• dry mouth
• constipation
• reduced appetite
• dizziness
• headache
• sexual side effects in females and males*
• sweating more than usual†
• trouble sleeping†
• headache
• belly pain

* In this article, we use the terms “female” and “male” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article. For details on sexual side effects Cymbalta may cause, see “Sexual side effects in women and men” below.
† To learn more about this side effect, see “Side effects explained” below.

In most cases, these side effects should be temporary. Some may be easily managed, too. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. And don’t stop using Cymbalta unless your doctor recommends it.

Cymbalta may cause mild side effects other than the ones listed above. See the Cymbalta medication guide for details.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Cymbalta, visit MedWatch.

Serious side effects from Cymbalta aren’t common, but they can happen. Serious side effects that have been reported with Cymbalta include:

• suicidal behaviors and thoughts*
• liver damage†
• eye problems†
• allergic reaction†‡
• fainting or dizziness when standing up
• blood pressure changes
• serotonin syndrome, a rare side effect of drugs that affect serotonin, a brain chemical
• low sodium levels
• urination problems
• severe skin reaction, such as Stevens-Johnson syndrome
• unusual bleeding or bruising

* Cymbalta has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see “Side effects explained” below.
† To learn more about this side effect, see “Side effects explained” below.
‡ An allergic reaction is possible after using Cymbalta. But this side effect wasn’t reported in studies.

If you develop serious side effects while taking Cymbalta, call your doctor right away. If the side effects seem life threatening or if you think you’re having a medical emergency, immediately call 911 or your local emergency number.

The most common side effects of Cymbalta in children may include:

• weight loss
• reduced appetite
• fatigue (lack of energy)
• nausea or vomiting
• diarrhea

Sexual side effects from taking Cymbalta are possible and may be more common in males than females.* In studies, sexual side effects were reported in a small percentage of males and females during Cymbalta treatment. Some of these side effects, such as erectile dysfunction, may be more likely to occur when taking a higher dosage of Cymbalta.

Males who took Cymbalta reported significantly more sexual side effects compared with those who took a placebo (a treatment that contains no active drug). The sexual side effects reported in males included:

• decrease in or loss of libido (sex drive)
• trouble becoming aroused
• erectile dysfunction
• difficulty reaching orgasm
• delayed ejaculation or being unable to ejaculate

Females who took Cymbalta also reported sexual side effects. But these side effects were similar to those experienced by females who received a placebo. Sexual side effects included:

• decreased libido (sex drive)
• trouble becoming aroused
• reduced vaginal lubrication
• difficulty reaching orgasm

Note that some males and females in this study reported improvements in sexual desire, performance, and satisfaction with Cymbalta treatment. This may be because the medication helped to reduce the symptoms of their condition. As a result, their sexual health may have also improved.

* In this article, we use the terms “female” and “male” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

Some side effects of Cymbalta can affect your long-term health, but this isn’t common.

For example, liver failure is a rare but serious side effect of Cymbalta. Heavy alcohol use may increase the risk of liver failure. The liver damage that develops from this side effect doesn’t go away once a person stops taking Cymbalta.

You may be wondering if it’s safe to take Cymbalta long term. Studies have tested the drug’s safety for up to 6 months. A 2009 study has shown Cymbalta to be safe to use when taken for 12 months. Your doctor can tell you about their understanding of long-term Cymbalta use.

It’s a good idea to go over all of your medications with your doctor every so often. Together, you can discuss your condition and consider whether you should continue Cymbalta long term.

Keep reading to get answers to some frequently asked questions about Cymbalta’s side effects.

How long do Cymbalta’s side effects last?

How long side effects from Cymbalta last can vary. Some of the more common side effects are usually temporary, such as sleepiness, dizziness, and reduced appetite. These side effects typically ease within a few days or weeks after starting treatment.

Common side effects may get worse after your doctor increases your dosage, but this is usually temporary.

Other side effects are more likely to continue for as long as you’re taking the drug. Examples include sweating more than usual and sexual side effects. These side effects usually aren’t severe.

Cymbalta side effects can affect each person differently. For example, nausea may be a mild, temporary side effect for some people. For others it can be bothersome. In studies, a small percentage of people had to stop taking the drug due to nausea.

If you’re experiencing troublesome side effects, you shouldn’t suddenly stop taking Cymbalta. It’s best to talk with your doctor first. If you and your doctor decide that you should stop the drug, they’ll guide you on how best to do so.

Do seniors have a higher risk for side effects from Cymbalta?

No, this doesn’t seem to be the case. In general, older adults (ages 65 years and older) have a higher risk for medication side effects compared with younger adults. But in studies of Cymbalta, older adults had similar side effects to those of younger adults.

Can Cymbalta cause weight gain?

Cymbalta doesn’t typically cause weight gain. In studies, weight gain wasn’t reported as a side effect.

In fact, weight loss is more likely than weight gain with Cymbalta. This is because the drug commonly causes reduced appetite and nausea.

These side effects may lead to weight loss, especially in children. Because of this, if your child is taking Cymbalta, their doctor will monitor your child’s weight and height during Cymbalta treatment.

If you have questions about weight changes with Cymbalta, talk with your doctor.

Will Cymbalta side effects differ depending on the strength I use (20 mg, 30 mg, or 60 mg)?

Some side effects of Cymbalta may be dependent on dose. Cymbalta comes in the following strengths: 20 milligrams (mg), 30 mg, and 60 mg. A higher strength of the drug might come with a higher risk of certain side effects.

Common dose-dependent side effects of Cymbalta include nausea, fatigue (lack of energy), constipation, dizziness, reduced appetite, and sweating more than usual.

Learn more about some of the side effects Cymbalta may cause.

Sweating more than usual

Sweating more than usual is a common side effect of Cymbalta. This side effect may be worse with higher doses of the drug. In addition, hot flashes (also called hot flushes) are a possible side effect of this medication.

Some people may notice increased sweating only in certain situations, such as when they’re active or during humid weather. Others may have increased sweating more often, including while trying to sleep.

What might help

Increased sweating isn’t a harmful side effect, but it may be uncomfortable. Here are a few tips that may help ease this side effect:

• Use a strong deodorant.
• Shower more often.
• Wear light fabrics
• Use a fan at night.

If this side effect continues to bother you, your doctor may suggest adjusting your dosage or switching to a different drug.

But if Cymbalta is particularly effective for your condition, you may not want to switch to a different drug. In this case, your doctor may suggest treatments for your sweating. Examples of drugs sometimes used to treat this side effect include:

• benztropine (Cogentin)
• cyproheptadine
• terazosin

If you have concerns about sweating more than usual with Cymbalta, talk with your doctor.

Eye problems

Eye problems aren’t a common side effect of Cymbalta. But this drug may increase the risk of serious eye problems, such as glaucoma (a buildup of pressure within the eye).

Cymbalta can cause a person’s pupils to dilate. This can trigger a serious eye problem, including vision loss, especially for someone who has closed-angle glaucoma. Symptoms can include:

• sudden vision changes
• eye pain
• eye redness
• swelling in or around your eye

What might help

If you have closed-angle glaucoma, you shouldn’t take Cymbalta. If you’re not sure whether you have this condition, consider visiting an eye doctor. The results of an eye exam can help you and your doctor decide if it’s safe for you to take Cymbalta.

If you develop any of the above symptoms while taking Cymbalta, you should seek medical attention. Urgent treatment is needed to help prevent permanent vision loss.

If you have questions about eye problems that Cymbalta may cause, talk with your doctor.

Liver damage

Although rare, Cymbalta can cause serious liver damage that could be fatal. The risk of this side effect may be higher with alcohol use. It could also be higher in people who already had liver problems before starting Cymbalta.

The following may indicate that there’s a problem with your liver:

• pain in the upper right part of your belly
• itching
• dark urine
• yellowing of your skin or whites of your eyes
• increased liver enzyme levels

What might help

To help prevent this side effect, talk with your doctor about any liver problems you’ve had. It’s also important to be honest about your alcohol consumption. Talk with your doctor about whether you’ve had problems with your liver or alcohol in the past.

If you develop any of the above symptoms, get emergency medical care right away.

Trouble sleeping

Insomnia (trouble falling asleep or staying asleep) can occur with Cymbalta. In studies, this side effect was more commonly reported in people taking the drug for long-term musculoskeletal pain. (This is pain in the bones, muscles, tendons, ligaments, and nerves. ) Waking up earlier than desired was also reported with Cymbalta.

Insomnia is also a common side effect reported in children taking Cymbalta.

What might help

Here are a few tips that may help to improve your sleep:

• Try to exercise regularly.
• Avoid caffeine after lunch.
• Practice good sleep hygiene.

If you’re having insomnia since starting Cymbalta, talk with your doctor. They may suggest the temporary use of a sleep aid, such as melatonin. Or they may adjust your dosage or discuss other treatment options with you.

Suicidal behaviors and thoughts

Cymbalta has a boxed warning for suicidal behaviors and thoughts. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.

Antidepressants such as Cymbalta may increase the risk of suicidal behaviors and thoughts in children and young adults ages 24 years or younger. This is a rare side effect. Studies show that the risk is higher after a person first starts treatment or increases their dose.

What might help

While taking Cymbalta, you should watch for any new behaviors, feelings, or thoughts. This is especially important in the first few weeks after starting Cymbalta or after your dose is adjusted.

Consider using a journal or app to make notes about your mood. You may want to ask your loved ones to let you know if they notice that you’re acting differently. Tell your doctor right away if you or someone else notices any changes in your behavior or moods.

Suicide prevention

If you think someone is at immediate risk of self-harm or hurting another person:

• Call 911 or your local emergency number.
• Stay with the person until help arrives.
• Remove any guns, knives, medications, or other things that may cause harm.
• Listen, but don’t judge, argue, threaten, or yell.

If you or someone you know is considering suicide, get help from a crisis or suicide prevention hotline. Try the National Suicide Prevention Lifeline at 800-273-8255.

Allergic reaction

Like most drugs, Cymbalta can cause an allergic reaction in some people. But this side effect wasn’t reported in studies.

Symptoms can be mild or serious and can include:

• skin rash
• itchiness
• flushing (temporary warmth, redness, or deepening of skin color)
• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. To manage symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine). Or they may recommend a product you apply to your skin, such as hydrocortisone cream.

If your doctor confirms you had a mild allergic reaction to Cymbalta, they’ll decide if you should continue using it.

If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you had a serious allergic reaction to Cymbalta, they may have you switch to a different treatment.

Keeping track of side effects

During Cymbalta treatment, consider keeping notes on any side effects you’re having. You can then share this information with your doctor. This is especially helpful to do when you first start taking new drugs or using a combination of treatments.

Your side effect notes can include things such as:

• what dose of drug you were taking when you had the side effect
• how soon after starting that dose you had the side effect
• what your symptoms were from the side effect
• how it affected your daily activities
• what other medications you were also taking
• any other information you feel is important

Keeping notes and sharing them with your doctor will help your doctor learn more about how Cymbalta affects you. Your doctor can use this information to adjust your treatment plan if needed.

Cymbalta has several warnings that may affect whether you can safely use this drug to treat your condition.

Boxed warning: Suicidal behaviors and thoughts

Cymbalta has a boxed warning for suicidal behaviors and thoughts. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

Antidepressants such as Cymbalta may increase the risk of suicidal behaviors and thoughts in children and young adults ages 24 years or younger. After starting Cymbalta, you should watch for any new behaviors, feelings, or thoughts. Tell your doctor right away if you or your loved ones notice any changes in your behavior or moods.

To learn more, see “Side effects explained” above.

Other warnings

Cymbalta may not be right for you if you have certain medical conditions or other factors that affect your health. Talk with your doctor about your health history before you take Cymbalta. The list below includes factors to consider.

Liver or kidney problems. The liver and kidneys help clear Cymbalta from the body. In a person who has liver or kidney problems, Cymbalta levels could become too high in their body. This can worsen the drug’s side effects. In rare cases, Cymbalta may cause liver failure. People who already have liver problems may be at higher risk for this side effect. Before taking Cymbalta, tell your doctor about any liver or kidney problems you have.

Closed-angle glaucoma. Cymbalta can cause the pupils to dilate, which may worsen certain eye problems. If you have closed-angle glaucoma, vision loss could occur with Cymbalta. Talk with your doctor about other treatment options.

Heart or blood pressure conditions. Cymbalta may increase your blood pressure. If you already have high blood pressure or heart problems, taking Cymbalta could worsen your condition. Before starting this drug, tell your doctor about any heart or blood pressure problems you may have.

Slow stomach emptying. Cymbalta capsules are delayed-release. As such, they have a special coating that helps protect the drug against the acid in your stomach. If you have a condition that can slow stomach emptying, such as diabetes, the special coating may get destroyed. This could make Cymbalta less effective for treating your condition. Before taking Cymbalta, talk with your doctor about any medical conditions that you have.

Diabetes. If you have diabetes, Cymbalta may make it more difficult to manage your blood sugar levels. Before taking Cymbalta, talk with your doctor about a plan for managing your blood sugar levels.

Seizures. Cymbalta may increase the risk of seizures. But the drug hasn’t been studied in people with epilepsy (a seizure disorder). If you have a seizure disorder, your doctor may suggest another treatment option for your condition.

Bipolar disorder or mania. Cymbalta may bring on or worsen certain symptoms of bipolar disorder or mania. If you have bipolar disorder or mania, talk with your doctor about the risks involved in taking Cymbalta. If you aren’t sure whether you have either condition, your doctor may screen you for them before you take Cymbalta.

Low sodium levels. Cymbalta can cause low sodium levels. If you have problems with your sodium levels, talk with your doctor before you take Cymbalta.

Bleeding problems. Cymbalta may raise your risk for bruising or bleeding problems. If you have a condition that causes bleeding problems, taking this drug may worsen your condition. Before starting Cymbalta, tell your doctor about any current or past bleeding problems.

Allergic reaction. If you’ve had an allergic reaction to Cymbalta or any of its ingredients, you shouldn’t take Cymbalta. Ask your doctor what other medications are better options for you.

Alcohol and Cymbalta

Drinking alcohol isn’t recommended with Cymbalta, especially heavy alcohol consumption.

Alcohol may worsen some of Cymbalta’s common side effects, such as:

• nausea
• sleepiness
• dizziness

Heavy alcohol consumption while taking Cymbalta can increase your risk for serious liver problems and liver failure. This can be life threatening.

If you drink alcohol, talk with your doctor about whether it’s safe for you to do so while taking Cymbalta. You can also ask them how much alcohol is safe for you to drink.

Pregnancy and breastfeeding while taking Cymbalta

Cymbalta use isn’t recommended during pregnancy because its effects aren’t fully known. The drug may cause harm to a developing fetus.

If you’re pregnant or you’re considering a pregnancy, talk with your doctor. They’ll tell you about treatment options that may be safer during this time.

Cymbalta passes into breast milk, and the drug may affect a child who is breastfed. There have been reports of drowsiness and feeding problems in children breastfed by people taking Cymbalta.

If you’re breastfeeding or have plans to breastfeed, talk with your doctor. They can help you weigh the pros and cons of breastfeeding while taking this drug.

Many people find that Cymbalta is an effective treatment for their condition. When you’re considering Cymbalta as a treatment option, it’s a good idea to talk with your doctor about your risk for side effects. Here are some questions that you may want to ask:

• Do my medical conditions increase my risk for side effects with Cymbalta?
• Are there other ways to help me manage side effects from Cymbalta?
• Are there any lifestyle changes I can make that may help to reduce my need to take Cymbalta in the future?

To learn more about Cymbalta, see these articles:

• Cymbalta (duloxetine)
• Cymbalta Interactions: Alcohol, Medications, and Others
• Dosage Details for Cymbalta

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.

Q:

My child has generalized anxiety disorder, and their doctor suggested Cymbalta treatment. I’m concerned about the drug’s suicide warning. How common or rare is this side effect, and how can it be avoided?

Anonymous patient

A:

The risk of suicidal behaviors and thoughts with Cymbalta use is rare. But Cymbalta does have a boxed warning for this side effect. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

When compared with a placebo (a treatment with no active drug), antidepressants such as Cymbalta were associated with increased suicidal behaviors and thoughts. This risk affected children and young adults ages 24 years and younger.

For more about this FDA boxed warning, see “Side effects explained” above.

If your child’s doctor prescribes Cymbalta, make sure to monitor your child for any changes in their behavior or mood. This is especially important when treatment with Cymbalta begins or the dosage is changed. Contact your child’s doctor right away if you notice any changes in your child’s behavior or mood.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

List of drugs for high blood pressure without side effects: names and features

Contents

• 1 List of effective drugs for pressure without negative effects
  • 1.1 List of safe drugs for lowering pressure
  • 1.2 Related videos:
  • 1.3 An high pressure atomy
  • 1.4 Choosing the right drugs to control high blood pressure
  • 1.5 Fast-acting drugs for high blood pressure: the need for immediate action
  • 1.6 High blood pressure tablets
  • 1.7 High blood pressure drops considerations
  • 1.8 High blood pressure inhibitors and antagonists
  • 1.9 Benefits of recommended high blood pressure drugs
    • 1.9.1 Safety
    • 1.9.2 Availability
    • 1.9 .3 Wide choice
  • 1.10 Popular medicines for high blood pressure available in pharmacies
    • 1. 10.1 Captopril
    • 1.10.2 Lozap
    • 1.10.3 Atenolol
    • 1.10.4 Enalapril
  • 1.11 Side effects of drugs for high blood pressure: how to avoid?
    • 1.11.1 Study the drug before taking
    • 1.11.2 Seek medical advice at the first sign of side effects
    • 1.11.3 Do not combine medicines without a doctor’s prescription
    • 1.11.4 Follow dosage and timing recommendations

    9000 5 1.11.5 Avoid drinking alcohol along with medications

  • 1.12 Medicines for high blood pressure without side effects: an overview
    • 1.12.1 What is high blood pressure?
    • 1.12.2 What are the medicines for high blood pressure?
    • 1.12.3 What medicines for high blood pressure without side effects are available?
  • 1.13 Q&A:
    • • 1.13.0.1 Which drugs on the list can be taken long-term?
      • 1.13.0.2 Can I take drugs from the list as part of complex therapy?
      • 1. 13.0.3 What should I do if my medication does not help reduce my blood pressure?
      • 1.13.0.4 Which of the medicines on the list can cause an allergic reaction?
      • 1.13.0.5 Can medicines on the list increase the risk of diabetes?
      • 1.13.0.6 Can drugs on the list lead to depression or other mental disorders?

List of safe blood pressure drugs without side effects. Brief characteristics and names of preparations. Choose an effective medicine without risk to health.

High blood pressure is a common problem that requires constant monitoring and treatment. However, many hypertension medications can cause unwanted side effects, making the treatment process even more difficult. The growing number of patients seeking alternative treatments has led the pharmaceutical industry to develop new drugs that do not cause unwanted effects.

There are many drugs on the market today that have been developed to treat hypertension without side effects. In this article, we’ll take a look at some of the most effective and safe medications that can help you lower your blood pressure without harming your health.

Many of these preparations are based on natural ingredients such as plant extracts or amino acids. They work similarly to classic hypertension medications, but are less likely to cause side effects. Some medications have additional benefits, such as improving overall cardiovascular function or having a calming effect on the nervous system.

List of safe blood pressure medicines

High blood pressure is a problem for many people. High blood pressure can lead to various diseases, but choosing medications can be difficult. It is important to choose a drug that is safe and effective and will not cause side effects.

• Enalapril is a medicine that lowers blood pressure. It can be used alone or in combination with other drugs. Among the advantages of this medicine is that it does not cause severe side effects.
• Chlorothiazide is a diuretic that can be used to control blood pressure. It works by reducing the amount of fluid in the body and removing it through the urine. The medicine can lead to a loss of potassium, so it is recommended to increase its intake.
• Nifedipine is a medicine that can be used to lower blood pressure and dilate blood vessels. Various forms of medication include tablets, capsules and films. In addition to lowering blood pressure, nifedipine may also help lower your heart rate.

The choice of a safe and effective medicine should only be made after consulting a doctor. Medication intake should be tailored to the individual needs and health status of the patient.

Related videos:

Anatomy of high blood pressure

High blood pressure is a condition in which blood exerts excessive pressure on the walls of the arteries. This condition can harm the health of the heart, kidneys, and brain.

When pressure is high, the heart has to work harder to pump blood through the arteries. At the same time, the walls of the arteries become less flexible and elastic, which leads to a deterioration in the blood supply to the organs.

High blood pressure can be caused by kidney failure, arteriosclerosis, thyroid dysfunction, and genetic factors.

Therefore, in case of high pressure, it is important to consult a doctor who will prescribe the appropriate treatment and help to avoid possible complications.

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Choosing the right medicines to control high blood pressure without unwanted side effects effects.

One option for drugs to control high blood pressure is ACE inhibitors. They work by blocking the action of the angiotensin-converting enzyme, which is directly related to blood pressure. ACE inhibitors may also reduce the risk of serious complications such as stroke and heart attack.

Another class of drugs are calcium channel blockers. They help relax the muscles in the walls of the arteries, thereby improving blood flow and reducing pressure. Calcium channel blockers may also improve angina symptoms.

1. Lisinopril is an ACE inhibitor that can be used to control high blood pressure. It helps relax the blood vessels and improves blood flow so that the blood can circulate more freely.
2. Amlodipine is a calcium channel blocker that helps relax artery walls and improve blood flow. It can be used to control high blood pressure and to improve the symptoms of angina.
3. Indapamide is a diuretic that can be used to control high blood pressure. It helps remove excess fluid from the body, which can reduce the workload on the heart and lower blood pressure.

Keep in mind that every patient is different, so the choice of drugs to control high blood pressure should not be made on your own. It is important to consult with a specialist who will help determine the best treatment option and choose the right medications.

Fast-acting drugs for high blood pressure: the need for immediate action

High blood pressure can lead to serious consequences such as stroke, heart attack and even death. Therefore, if speed is needed, doctors can prescribe medications that act within a few minutes after application.

Fast-acting high blood pressure medications include Captopril, Enalapril, Nifedipine, and Phenoxybenzamine. They quickly enter the bloodstream and reduce blood vessels, which reduces pressure.

However, be aware that fast-acting drugs have side effects and can lead to coronary heart disease, headaches, nausea, and other symptoms. Therefore, the appointment of such funds should be carried out only by a doctor in strict accordance with the dosage and individual characteristics of the patient.

• Captopril: a drug that improves the patient’s condition by reducing the load in cardiovascular diseases.
• Enalapril: medicine used to treat high blood pressure, heart failure and other cardiovascular diseases.
• Nifedipine: a drug that reduces the workload on the heart and reduces the risk of heart attacks and strokes.
• Phenoxybenzamine: a vasodilating agent that improves microcirculation and protects the walls of arteries and veins.

Tablets for high blood pressure

Hypertension treatment involves the use of tablets to help lower blood pressure. However, choosing the right drug can be tricky, as each has its own characteristics and side effects.

• Lisinopril is an angiotensin-converting enzyme (ACE) that blocks the conversion of angiotensin I to angiotensin II, which raises blood pressure. Lisinopril reduces blood pressure and reduces the risk of unpleasant consequences of hypertension. However, the pressure reduction process may take some time.
• Amlodipine is a calcium channel blocker that dilates blood vessels and increases blood flow. Amlodipine is indicated in cases where other drugs are not suitable. However, this drug may cause side effects such as swelling and dizziness.
• Moxonidine is an imidazoline receptor agonist that reduces sympathetic nervous system activity and pressure. The drug has a long-term effect and is well tolerated by patients. However, it can cause dry mouth and drowsiness.

The choice of tablets for high blood pressure should be made by the doctor based on the individual characteristics of the patient and concomitant diseases. Patients should follow the medications prescribed by the doctor and not change the dosage without his permission.

High blood pressure drops

High blood pressure drops are often used to relieve symptoms and lower blood pressure. But not all drops are equally effective and safe for the patient. Therefore, the appointment of drops should be made only by a doctor and after a preliminary examination of the patient.

One of the features of prescribing drops for high blood pressure is an individual approach to each patient. This is due to the fact that each person has his own characteristics of the organism and requires an individual choice of the drug.

An important point in the appointment of drops from high blood pressure is to comply with the dosage and frequency of administration. Excess use of drops can lead to various side effects such as dizziness, nausea and drowsiness.

Some high blood pressure drops may be contraindicated in certain medical conditions such as liver, kidney and cardiovascular diseases. Therefore, before prescribing drops, it is necessary to study the patient’s medical history, as well as conduct an additional examination to identify possible contraindications.

In general, with the correct prescription and use of high blood pressure drops, good results can be achieved in lowering blood pressure and alleviating the symptoms of hypertension. But for this it is necessary to follow all the recommendations and prescriptions of the doctor, and also not to abuse the drops.

Inhibitors and antagonists for lowering blood pressure

Some of the most common drugs for lowering high blood pressure are ACE inhibitors and angiotensin II receptor antagonists.

ACE inhibitors help relax blood vessels by blocking the action of an enzyme that increases blood pressure and improve blood flow. These drugs can quickly and effectively lower blood pressure, but may cause coughing and other side effects.

Angiotensin II receptor antagonists also block the action of a certain hormone that disrupts the normal functioning of the heart and blood vessels, which in turn also lowers blood pressure. These drugs are better tolerated by patients and may be effective in controlling high blood pressure over time.

• Examples of ACE inhibitors:
  • Enalapril : may cause coughing or cause a decrease in white blood cell count, but is one of the most common drugs for treating high blood pressure.
  • Ramipril : generally well tolerated by patients and may improve cardiac performance.
• Examples of angiotensin II receptor antagonists:
  • Losartan : may reduce the risk of stroke, heart attacks, but in rare cases may cause dizziness or lead to changes in the quality of vision.
  • Valsartan : Helps improve heart and kidney function, but may cause muscle and joint pain.

As with any drug, consultation with a doctor is necessary to select the optimal drug and determine the dosage. Also remember to follow your medication regimen and consult your doctor if any side effects occur.

Benefits of Recommended High Blood Pressure Medicines

Safety

Recommended High Blood Pressure Medicines provide the highest level of safety for patients. They can be used to treat high blood pressure without the risk of serious side effects. In addition, the effect of the use of these drugs comes on quickly and lasts a long time.

Availability

Most recommended medicines are available without a prescription at almost any pharmacy. In this regard, the choice of a suitable drug does not cause problems. In addition, the price of recommended high blood pressure medications is quite affordable, making it easy for patients to purchase the necessary blood pressure medications.

Wide choice

Today there are many medicines for high blood pressure that are recommended by doctors. Each person can choose the most suitable gymnasium of them, taking into account the individual characteristics of the organism. In addition, the choice is open to diversity, as both traditional and alternative treatments for high blood pressure are available. All this allows patients to better control their diseases and achieve the best result.

Popular medicines for high blood pressure available in pharmacies

Captopril

Features: Captopril is an ACE inhibitor that lowers blood pressure by dilating blood vessels. It can also help reduce stress on the heart muscle, improve kidney function, and prevent the effects of a stroke.

Lozap

Features: Lozap is an AT1 receptor antagonist that blocks the action of angiotensin II, a hormone that increases blood pressure. It helps lower blood pressure and reduce the risk of cardiovascular disease.

Atenolol

Features: Atenolol is a beta blocker that blocks the action of epinephrine and norepinephrine on the heart and blood vessels. It lowers heart rate and blood pressure, reduces stress on the heart, and helps prevent myocardial infarction and stroke.

Enalapril

Features: Enalapril is an ACE inhibitor that lowers blood pressure and reduces workload on the heart. It may also help improve kidney function and prevent heart failure.

• It is important to remember that when choosing a medicine for high blood pressure, you should consult a doctor and consult a pharmacist.
• Some medicines may cause side effects, so read the package leaflet for information.

High blood pressure medication side effects: how to avoid?

Read the medication before taking

Before you start taking medicine for high blood pressure, read the package leaflet and learn about possible side effects. It is important to familiarize yourself with the dosages, contraindications and method of application.

Seek medical advice at the first sign of side effects

If symptoms of side effects occur while taking the medicine, you should immediately consult a doctor. It is important not to stop taking the drug without consulting a doctor, as this may lead to a worsening of the condition.

Do not combine medicines without a doctor’s prescription

Combining different medicines can lead to unwanted side effects and poor health. Therefore, it is necessary to take only those medicines that have been prescribed by a particular doctor.

Follow dosage and timing recommendations

It is important to follow your doctor’s dosage and timing recommendations. Do not change the dosage or time of administration without consulting your doctor. This can lead to unwanted side effects and poor health.

Avoid drinking alcohol with medications

Using alcohol and high blood pressure medications together can lead to poor health and unwanted side effects. Therefore, alcohol should be avoided while taking medication.

High blood pressure drugs without side effects: an overview

What is high blood pressure?

High blood pressure (hypertension) is a condition in which the blood puts a lot of pressure on the walls of blood vessels. Often this leads to serious consequences such as stroke, heart attack, or even death. An increase in blood pressure occurs when the heart works too hard to pump blood through tight vessels. High blood pressure medications without side effects are often used to treat hypertension.

What are the medicines for high blood pressure?

There are many drugs used to treat hypertension, but not all of them are suitable for all patients. Some drugs may have side effects such as dizziness, nausea, or sleep disturbance. However, there is a group of medicines for high blood pressure without side effects that can be recommended to patients.

What medicines for high blood pressure without side effects are there?

• ACE inhibitors are drugs that reduce blood pressure by blocking the action of an enzyme responsible for vasoconstriction. These drugs include captopril, enalapril and lisinopril.
• Calcium antagonists – block the calcium channels of the heart and blood vessels, reducing heart contraction and dilating blood vessels, which leads to a decrease in pressure. From this group it is worth highlighting Amlodipine and Nifedipine.
• Diuretics – pressure reduction is associated with the removal of excess fluid from the body. From this group of drugs, Indapamide and Glimezid can be recommended.

Of course, before using any medicine for high blood pressure, you should consult with your doctor in order to choose the optimal course of treatment, dosage and choose a drug that will not cause negative consequences.

Q&A:

Which drugs on the list can be taken long-term?

From the list of drugs for high blood pressure without side effects for long-term use are suitable: captopril, losartan, metoprolol. They do not cause serious side effects and control blood pressure well.

Can I take drugs from the list as part of complex therapy?

Yes, drugs from the list can be used in complex therapy. However, the appointment and dosage should be determined by the physician depending on the health status and needs of the patient.

What should I do if my medication does not help reduce my blood pressure?

If medication does not help reduce blood pressure, you should immediately consult a doctor to adjust the therapy. You may need to change the dosage, prescribe other medications or additional treatments.

Which of the medicines on the list can cause an allergic reaction?

All medicines can cause an allergic reaction, but this is most common with ACE inhibitors such as captopril. In case of allergic symptoms (skin rash, itching, swelling), stop taking the drug and consult a doctor.

Can medicines on the list increase the risk of diabetes?

Some medicines on the list may increase your risk of developing diabetes. For example, beta blockers such as metoprolol can decrease insulin sensitivity. Therefore, when using these medications, it is important to monitor your blood sugar levels and adjust your insulin dose if necessary.

Can drugs on the list cause depression or other mental disorders?

Medicines on the list may cause drowsiness, fatigue, sleep disturbances, and other mental health problems in some patients. However, this is rare and is usually associated with individual sensitivity to the drug. If such symptoms appear, you should consult a doctor who will select a more suitable medicine.

Do weight loss drugs affect blood pressure and reduce the effects of high blood pressure (hypertension, hypertension)?

What is high blood pressure (hypertension)?

Blood pressure is a measure of the force your heart uses to pump blood around your body. It is usually expressed as two values: the pressure when your heart pushes blood out (systolic pressure) and the pressure when your heart rests between beats (diastolic pressure). Blood pressure is considered high if systolic pressure is over 140 and/or diastolic pressure is over 90, often referred to as “140 over 90” (140/90) and measured in millimeters of mercury (mmHg). As we age, the risk of high blood pressure increases.

Hypertension can increase a person’s risk of serious long-term health problems such as heart attack or stroke. Lowering blood pressure in people with hypertension reduces the number of patients with heart and vascular disease (cardiovascular disease), resulting in reduced mortality and cardiovascular disease.

Weight and hypertension

Guidelines for the management of hypertension recommend maintaining a healthy weight and, if necessary, reducing it. Some people may take medication to help with weight loss.

Why did we prepare this Cochrane Review?

Drugs licensed for use in weight loss in the US and Europe include orlistat and naltrexone in combination with bupropion. Another combination, phentermine with topiramate, is licensed in the US only. We wanted to find out whether weight loss medications have a long-term effect on blood pressure and whether they can reduce the undesirable effects of high blood pressure on people’s health.

What have we done?

We searched for studies on the effects of taking weight loss medications in people with high blood pressure. We were interested in how these drugs affect blood pressure and body weight. We also wanted to find out how many patients experienced side effects, how many developed cardiovascular disease, and whether there were any deaths.

We searched for randomized controlled trials in which the decision about the intervention people received was made at random. This type of study tends to provide the most reliable evidence about the effects of treatment.

We assessed the reliability of the evidence found. We considered the following factors: how the studies were conducted, how many people participated in them, and whether their results were consistent with each other.

Search date: we have included evidence published up to March 2020.

What we found out

We found six studies involving 12,724 patients with high blood pressure (mean age 46-62 years). The studies were conducted in the USA (3 studies) and Europe (3 studies) and lasted from 6 to 28 months.

All studies compared the effects of taking a weight loss drug with the effects of taking a fake drug (placebo).

What are the results of our review?

Orlistat may reduce weight and possibly lower blood pressure (4 studies; 2058 people).

Phentermine plus topiramate may reduce weight and lower blood pressure (1 study; 1305 people).

The combination of naltrexone and bupropion appears to reduce weight but does not appear to lower blood pressure (1 study; 8283 people).

One study looked at risk of death and major adverse cardiovascular effects; it found no difference between treatment with naltrexone plus bupropion and placebo at two years.

People taking weight loss medications reported more adverse effects than those taking placebo. The most common adverse effects were digestive problems (for orlistat and phentermine with topiramate), dry mouth, and skin tingling or numbness (for naltrexone with bupropion).

How reliable are these results?

Results were obtained from a small number of studies. Some studies had few events for some measures (outcomes) that we were interested in.

Our confidence in how orlistat and naltrexone in combination with bupropion affect weight loss and blood pressure is moderate. However, the results may change if more evidence becomes available.

We are less certain about the effects of phentermine with topiramate; adverse effects of orlistat, as well as the risk of adverse cardiovascular events associated with naltrexone in combination with bupropion. These results are likely to change as more evidence becomes available.

Terminals

Some weight loss medications reduce weight and blood pressure in people with high blood pressure, but may cause unwanted effects. We did not find sufficient evidence that taking weight loss medications can reduce mortality and cardiovascular disease.