What is Deplin and how does it work. How is Deplin different from over-the-counter folic acid supplements. What are the potential side effects and interactions of Deplin. How should Deplin be dosed and administered. Who can benefit from taking Deplin.

Understanding Deplin: A Powerful Form of Folate

Deplin is a prescription medical food containing L-methylfolate, the active form of folate (vitamin B9). Unlike over-the-counter folic acid supplements, Deplin provides folate that is already activated and ready for use by the body. This makes it particularly beneficial for individuals who have difficulty converting folic acid into its active form.

The Science Behind Deplin

Folate plays a crucial role in numerous bodily functions, including DNA synthesis, cell division, and the production of neurotransmitters that regulate mood. L-methylfolate, the form found in Deplin, is able to cross the blood-brain barrier and directly support the synthesis of serotonin, dopamine, and norepinephrine.

Indications for Deplin Use

Deplin is primarily indicated as an adjunctive therapy for depression. It may be particularly helpful for individuals who have not responded adequately to traditional antidepressant medications. Additionally, Deplin may be beneficial in the following situations:

• Folate deficiency
• Certain genetic variations affecting folate metabolism
• Pregnancy (to prevent neural tube defects)
• Cardiovascular health support
• Cognitive function improvement

Deplin Dosing and Administration

The typical dosage of Deplin is 7.5 mg or 15 mg once daily, taken orally with or without food. Your healthcare provider will determine the appropriate dose based on your individual needs and medical condition.

Is there a specific time of day to take Deplin?

Deplin can be taken at any time of day. However, for optimal absorption and to establish a consistent routine, it’s generally recommended to take it at the same time each day. Some people prefer taking it in the morning, while others find it beneficial to take it with their evening meal.

Deplin vs. Over-the-Counter Folic Acid: Key Differences

Understanding the distinctions between Deplin and traditional folic acid supplements is crucial for optimizing folate supplementation. Here are the primary differences:

1. Form of folate: Deplin contains L-methylfolate, while most OTC supplements contain folic acid.
2. Activation: L-methylfolate is already active, whereas folic acid requires conversion by the body.
3. Absorption: L-methylfolate is more readily absorbed and utilized, especially in individuals with certain genetic variations.
4. Dosage: Deplin typically provides higher doses of active folate compared to OTC supplements.
5. Regulation: Deplin is a prescription medical food, subject to stricter quality control and regulatory oversight.

Why might Deplin be more effective than OTC folic acid for some individuals?

Up to 70% of people with depression may have a compromised ability to convert folic acid into its active form due to genetic variations or other factors. By providing already-active L-methylfolate, Deplin bypasses this conversion step, ensuring that the body receives the folate it needs to support neurotransmitter production and overall health.

Potential Side Effects and Safety Considerations

Deplin is generally well-tolerated, with side effects comparable to those of a placebo in clinical trials. However, as with any medication or supplement, some individuals may experience adverse effects. Common side effects may include:

• Nausea
• Stomach upset
• Headache
• Difficulty sleeping
• Irritability

It’s important to note that Deplin does not typically cause the side effects associated with traditional antidepressants, such as weight gain, sexual dysfunction, or insomnia. However, always consult your healthcare provider if you experience any unusual or persistent side effects.

Can Deplin interact with other medications?

While Deplin is generally safe to take with most medications, including antidepressants, it’s essential to inform your healthcare provider about all medications, supplements, and herbal products you are using. Some potential interactions to be aware of include:

• Methotrexate: Deplin may decrease the effectiveness of this medication used to treat certain cancers and autoimmune conditions.
• Anticonvulsants: Some anticonvulsant medications may interfere with folate metabolism.
• Antibiotics: Certain antibiotics may reduce folate absorption.

Who Can Benefit from Taking Deplin?

Deplin may be particularly beneficial for individuals in the following categories:

1. People with treatment-resistant depression
2. Individuals with MTHFR gene mutations affecting folate metabolism
3. Pregnant women or those planning to become pregnant
4. People with cardiovascular risk factors
5. Individuals with cognitive impairment or at risk for neurodegenerative diseases
6. Those with conditions affecting folate absorption, such as celiac disease or inflammatory bowel disorders

How can I determine if Deplin is right for me?

The best way to determine if Deplin is appropriate for your needs is to consult with a healthcare professional. They may consider factors such as your medical history, current medications, symptoms, and potentially order genetic testing to assess your folate metabolism. Based on this information, they can recommend whether Deplin or another form of folate supplementation would be most beneficial for you.

The Role of Deplin in Depression Treatment

Depression is a complex disorder that often requires a multifaceted approach to treatment. Deplin can play a significant role in supporting overall mental health and enhancing the effectiveness of antidepressant medications. Here’s how Deplin may contribute to depression management:

• Neurotransmitter support: L-methylfolate is essential for the production of serotonin, dopamine, and norepinephrine, which are key neurotransmitters involved in mood regulation.
• Enhanced medication efficacy: By addressing potential folate deficiencies or metabolic issues, Deplin may help improve the response to antidepressant medications.
• Reduced side effects: Some studies suggest that L-methylfolate supplementation may help mitigate certain side effects associated with antidepressant use.
• Cognitive function: Folate plays a role in cognitive processes, and addressing folate deficiency may help improve focus and mental clarity in individuals with depression.

How long does it take to see results from Deplin?

The time frame for experiencing benefits from Deplin can vary among individuals. Some people may notice improvements in mood and energy levels within a few weeks, while others may require several months of consistent use to see significant changes. It’s important to continue taking Deplin as prescribed and communicate regularly with your healthcare provider about your progress.

Deplin and Cardiovascular Health

Beyond its role in mental health, Deplin may also offer cardiovascular benefits. L-methylfolate is involved in the regulation of homocysteine levels, an amino acid that, when elevated, is associated with increased risk of cardiovascular disease. By supporting healthy homocysteine metabolism, Deplin may contribute to overall heart health.

Potential cardiovascular benefits of Deplin:

• Homocysteine reduction
• Improved endothelial function
• Support for healthy blood pressure levels
• Potential reduction in inflammation markers

While these potential benefits are promising, it’s important to note that Deplin should not be used as a substitute for conventional cardiovascular treatments. Always consult with your healthcare provider for comprehensive cardiovascular care.

Accessing and Affording Deplin

As a prescription medical food, Deplin may not be covered by all insurance plans. However, there are several options available to help make Deplin more accessible and affordable:

1. Brand Direct Health® pharmacy: This program offers savings, support, and resources to patients prescribed Deplin. To learn more or fill your prescription through Brand Direct Health® pharmacy, call 1-866-331-6440 or visit their website.
2. Manufacturer coupons: Check the official Deplin website for any available coupons or savings programs.
3. Patient assistance programs: Some pharmaceutical companies offer programs to help eligible patients access their medications at reduced costs.
4. Generic alternatives: While not identical to Deplin, there are generic L-methylfolate supplements available that may be more affordable. Discuss these options with your healthcare provider.

How can I ensure I’m getting authentic Deplin?

To ensure you’re receiving genuine Deplin, always obtain your prescription from a licensed healthcare provider and fill it at a reputable pharmacy. Be cautious of online sellers offering Deplin without a prescription, as these may be counterfeit or substandard products. If you have concerns about the authenticity of your Deplin, contact the manufacturer or consult your pharmacist.

Monitoring and Optimizing Deplin Therapy

To maximize the benefits of Deplin and ensure its safe use, it’s important to work closely with your healthcare provider throughout your treatment. Here are some key aspects of monitoring and optimizing Deplin therapy:

• Regular follow-ups: Schedule regular appointments to discuss your progress and any side effects or concerns.
• Blood tests: Your provider may recommend periodic blood tests to monitor folate levels and other relevant markers.
• Symptom tracking: Keep a journal of your mood, energy levels, and any changes in symptoms to help assess the effectiveness of Deplin.
• Lifestyle factors: Discuss how diet, exercise, and stress management can complement Deplin therapy.
• Medication adjustments: Your healthcare provider may need to adjust your Deplin dosage or other medications based on your response to treatment.

Are there any lifestyle changes that can enhance the effectiveness of Deplin?

While Deplin can be beneficial on its own, certain lifestyle factors can complement its effects and support overall health. Consider incorporating the following practices:

1. Balanced diet: Consume a variety of folate-rich foods, such as leafy greens, legumes, and fortified grains.
2. Regular exercise: Physical activity can help boost mood and overall well-being.
3. Stress reduction: Practice stress-management techniques like meditation, yoga, or deep breathing exercises.
4. Adequate sleep: Prioritize getting 7-9 hours of quality sleep each night.
5. Limited alcohol consumption: Excessive alcohol intake can interfere with folate metabolism.

By combining Deplin with these healthy lifestyle practices, you may experience enhanced benefits and improved overall health outcomes.

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Product Information

How can DEPLIN

^® help me?

DEPLIN^® can provide the body with already-active folate that is ready to help promote the production of natural chemicals in the brain that affect mood and help you get the most out of your antidepressant therapy.

Is DEPLIN

^® safe? What are the side effects?

Yes, DEPLIN^® is generally safe and does not have the side effects of traditional antidepressants. In clinical trials, the side effects of DEPLIN^® were about the same as those of a placebo (a pill or liquid with no active medicine, such as a sugar pill). DEPLIN^®, which is safe to take with antidepressant medications when taken as indicated, is not associated with weight gain, insomnia, or sexual dysfunction.

How is DEPLIN

^® different from over-the-counter (OTC) options?

OTC folic acid needs to be activated by your body before it can be used. Unfortunately, up to 70% of people with depression may have a compromised ability to complete this activation. DEPLIN^® capsules can provide you with already-active folate so your body does not have to activate it for you to see a benefit. DEPLIN^® addresses the body’s nutritional requirements and creates an environment that allows you to get the most out of your antidepressant therapy.

Is there a program to help me save on my prescription?

Yes, you can save on DEPLIN^® with Brand Direct Health^® pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health^® pharmacy, call 1-866-331-6440 or visit www.branddirecthealth.com to learn more.

Symptoms of depression can include:

• Sadness
• Loss of interest or pleasure in activities you used to enjoy
• Change in weight/appetite
• Difficulty sleeping or oversleeping
• Low concentration/Trouble making decisions
• Energy loss/Feeling slowed down
• Feelings of worthlessness
• Thoughts of death or suicide

Adapted from the MedlinePlus website.

Deplin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Folic acid is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.Folic acid supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of folic acid either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Deplin

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Folic acid usually has very few side effects. If you have any unusual effects from taking this product, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this product, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this product do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this product, tell your doctor or pharmacist your medical history, especially of: vitamin B-12 deficiency (pernicious anemia).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Folic acid is safe to take during pregnancy when used as directed. It is included in prenatal vitamin products. Certain spinal cord birth defects may be prevented by taking adequate amounts of folic acid during pregnancy. Consult your doctor for more details.

Folic acid passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Deplin interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: mental/mood changes.

Do not share this medication with others.

Lab and/or medical tests (such as complete blood count, folate blood level, vitamin B-12 blood level) should be done while you are taking this product. Keep all medical and lab appointments. Consult your doctor for more details.

Folate is naturally found in leafy green vegetables, organ meats (liver, kidney), citrus fruits, and other foods. Folic acid is added to enriched grain products such as bread, pasta, and cereal. Consult your doctor or dietician for a diet plan rich in folate/folic acid.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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instructions for use, dosages, composition, analogues, side effects / Pillintrip

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Page reviewed by pharmacist Fedorchenko Olga Valerievna Last update 2022-03-12

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The information on this page is for healthcare professionals only!
The information is collected from open sources and may contain significant errors!
Be careful and double-check all the information on this page!

Top 20 drugs with the same ingredients:

Gyno-TardyferonFolbiolFerronemiaFolicilFysiofolBialferFolavitMaltofer FolMaterfolFeofolFolicronTardyferon FolFefolFolimenUniferolFolic AcidFolviteGyno TardyferonFolasHuma-Folaci d

Top 20 drugs with the same use:

Maxifol 5000FolsanHBHHAcide Folique ArrowFegemFol LichtensteinFolacFolivitalPediafolicFolsäure-ratiopharmAcfolAcide Folique CCDAndreafolFilicineAcido Folico A. M.AcifolFolaci dFolic Acid-Tsiteli AFolimaxFolin

Name of the drug

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Deplin

Composition

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Folic Acid

Therapeutic Indications

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folate deficiency anemia;

Hypo- and avitaminosis of folic acid (including with tropical sprue, celiac disease, malnutrition).

treatment and prevention of folic acid deficiency due to unbalanced or malnutrition;

treatment and prevention of anemia due to folic acid deficiency: macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, postresection anemia, sideroblastic anemia in the elderly, anemia associated with diseases of the small intestine, sprue and malabsorption syndrome ;

treatment and prevention of anemia during pregnancy and lactation;

during pregnancy – prevention of the development of neural tube defects in the fetus;

long-term treatment with folic acid antagonists (methotrexate, a combination of sulfamethoxazole and trimethoprim), anticonvulsants (phenytoin, primidone, phenobarbital).

Dosage and Administration

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Int.

Folate deficiency anemia: adults and children of any age starting dose – 1 mg / day. At high doses, resistance may occur.

Maintenance treatment: neonatal 0.1 mg/day; for children under 4 years old – 0.3 mg / day; for children over 4 years old and adults – 0.4 mg / day; during pregnancy and lactation – from 0.1 to 0. 8 mg / day.

With hypo- and avitaminosis of folic acid (depending on the severity of avitaminosis): adults – up to 5 mg / day; children – in smaller doses depending on age. The course of treatment is 20-30 days.

With concomitant alcoholism, hemolytic anemia, chronic infectious diseases, after gastrectomy, malabsorption syndrome, liver failure, liver cirrhosis, stress, the dose of the drug should be increased to 5 mg / day.

Treatment of megaloblastic anemia due to folic acid deficiency – 5 mg / day for 4 months, prevention – 2.5 mg / day.

Prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel disease and unbalanced or malnutrition – 15 mg / day, in patients with sprue – 5-15 mg / day.

Prevention of the development of neural tube defects in the fetus – 2.5 mg / day for 4 weeks before the expected pregnancy, continue taking it during the first trimester of pregnancy.

Higher maintenance doses may be given to patients suffering from alcoholism, as well as to patients with chronic infections and taking anticonvulsants.

Contraindications

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hypersensitivity to drug components;

B ₁₂ – deficiency anemia;

sucrase deficiency;

isomaltase deficiency;

fructose intolerance;

glucose-galactose malabsorption;

children’s age (up to 3 years).

Precautions: folate deficiency anemia with cyanocobalamin deficiency.

hypersensitivity to drug components;

pernicious anemia;

malignant neoplasms;

cobalamin deficiency.

Adverse effects

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Allergic reactions – skin rash, pruritus, bronchospasm, erythema, hyperthermia.

Allergic reactions: possible development of skin rashes, itching, erythema, bronchospasm.

From the gastrointestinal tract: anorexia, nausea, bloating, bitterness in the mouth.

Overdose

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Doses of folic acid up to 4–5 mg are well tolerated. Higher doses may cause CNS and GI disturbances.

No cases of overdose have been reported.

Pharmacodynamics

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Vitamin B group (vitamin B _c , vitamin B ₉ ), can be synthesized and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine.

Vitamin B. In the body it is converted into tetrahydrofolic acid, which is involved in various metabolic processes as a coenzyme and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. With a deficiency of folic acid, a megaloblastic type of hematopoiesis develops. Stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine. During pregnancy, it performs a protective function in relation to the action of teratogenic and fetal-damaging factors. Contributes to the normal maturation and functioning of the placenta.

Pharmacokinetics

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Folic acid is well and completely absorbed in the gastrointestinal tract, mainly in the upper duodenum (even in the presence of malabsorption syndrome against the background of tropical sprue).

Intensively binds to plasma proteins. Penetrates through the BBB, the placenta, and also into breast milk. T _max – 30-60 min. It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase).

Excreted by the kidneys mainly as metabolites. If the accepted dose significantly exceeds the daily requirement for folic acid, then it is excreted unchanged.

Eliminated by hemodialysis.

After oral administration, folic acid, combining in the stomach with the internal factor of Castle (a specific glycoprotein), is well and completely absorbed in the gastrointestinal tract. Almost completely bound to plasma proteins.

Deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of the enzyme dihydrofolate reductase). Penetrates through the BBB, the placenta and into breast milk. C _max in the blood is achieved in 30–60 minutes. It is excreted by the kidneys both unchanged (if the accepted dose significantly exceeds the daily requirement), and in the form of metabolites. Excreted by hemodialysis. 5 mg of folic acid taken orally is excreted from the body after 5 hours.0072 . Be
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Anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.

Antacids (including calcium, aluminum and magnesium preparations), cholestyramine, sulfonamides (including sulfasalazine) reduce the absorption of folic acid.

Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (calcium folinate should be given instead in patients using these drugs).

There is no definitive information regarding zinc preparations: some studies show that folate inhibits zinc absorption, others do not.

When used simultaneously with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid is reduced.

With simultaneous use, folic acid reduces the effects of oral contraceptives, ethanol, sulfasalazine, cycloserine and glutethimide, methotrexate, phenytoin, primidone, chloramphenicol.

Folic acid may decrease plasma levels of phenobarbital, phenytoin, or primidone and cause an epileptic seizure.

Decreased or altered absorption may occur with co-administration of cholestyramine and folic acid, so folic acid should be taken 1 hour before or 4 to 6 hours after cholestyramine.

Pharmacological group

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• Hemopoiesis stimulants
• Vitamins and vitamin-like preparations

• Vitamin; hematopoiesis stimulator [Hematopoiesis stimulants]
• Vitamin; hematopoiesis stimulant [Vitamins and vitamin-like products]

Deplin price

We don’t have exact price data for this medicine.
However, we will provide data for each active ingredient

The average cost of Folic Acid 5 mg per unit in online pharmacies is from $0.25 to $0.84, per package from $25 to $92.

The average cost of Folic Acid 1 mg per unit in online pharmacies is from $0.21 to $0.21, per package from $21 to $21.

Sources:

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• https://pubmed.ncbi.nlm.nih.gov/?term=deplin

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Deplin (L-Methylfolate [from Metafolin] and Algae-S Powder [Schizochytrium] Therapeutic Nutrition Prescription): Uses, Dosage, Side Effects, Interactions, Warning

Full

• Generic Name: l-methylfolate [from metafolin] and seaweed powder [schizophrenia] Prescription Health Nutrition
• Brand Name: Complete

• Product description
• Indications and dosage
• Side effects and drug interactions
• Warnings and precautions
• Overdose and contraindications
• Clinical pharmacology
• Medication Guide

Product Description

FULL 7. 5 capsules

FULL 15 capsules

DESCRIPTION

DEPLIN is a prescription medical food for use only under the supervision of a physician for the clinical dietary treatment of depression and schizophrenia and is specifically formulated to meet the specific nutritional requirements of these conditions.

Each DEPLIN 7.5 capsule contains 7.5 mg of L-methylfolate (from Metafolin) and 90.314 mg of Algae-S powder (Schizochytrium). CAS No. 151533-22-1

Each DEPLIN 15 capsule contains 15.0 mg of L-methylfolate (from Metafolin) and 90.314 mg Algae-S powder (Schizochytrium). CAS No. 151533-22-1

how much milk thistle per day

Ingredients

COMPLETE 7.5

Silicified Microcrystalline Cellulose, Algae-S Powder (Schizochytrium Algae Oil [vegetable source], Glucose Syrup Solids, Mannitol, Sodium Caseinate (Milk), Soy Protein, High Oleic Sunflower Oil, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate, natural flavors, soy lecithin, and a mixture of natural tocopherols and ascorbyl palmitate [as antioxidants]), Pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source), FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, FD&C Yellow #6 Aluminum Lake, Shellac. Contains milk and soy

FULL 15

Siliconized microcrystalline cellulose, Algae-S powder (Schizochytrium algae oil [vegetable source], glucose syrup solids, mannitol, sodium caseinate (milk), soy protein, high sunflower oil oleic acid, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate Natural flavors, soy lecithin and mixed natural tocopherols and ascorbyl palmitate [as antioxidants]), pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source) )], FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, shellac. Contains milk and soy

DEPLIN is a medical prescription food for use only under medical supervision.

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Medical foods are intended for patients who have a limited or impaired ability to take in, digest, absorb, or metabolize common foods or certain nutrients, or who have other special medical nutritional requirements for which dietary regulation cannot be achieved by modifications. just a normal diet. ¹ This product is not an Orange Book product.

RECOMMENDATIONS

1. US Food and Drug Administration 21 CFR 101.9(j)(8).

Adverse effects and drug interactions

SIDE EFFECTS

Allergic reactions have been reported following oral administration of L-methylfolate. ¹¹

DRUG INTERACTIONS

Information not provided

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RECOMMENDATIONS

11. Natural Standards Collaboration (NIH). Folate (Folic Acid) 2009 Monograph.

PRECAUTIONS

General

L-methylfolate (DEPLIN) is not interchangeable with folic acid. In some patients, folic acid is not effective in influencing folic acid levels in the brain due to the low rate of transport of folic acid across the blood-brain barrier and/or low levels in the brain of an enzyme needed to convert folic acid into a biological and functional form. ^7-9

Patients at risk of vitamin B12 deficiency should consult their physician before taking L-methylfolate.