What is Deplin and how does it work. How is Deplin different from over-the-counter folic acid supplements. What are the recommended dosages and potential side effects of Deplin. How can Deplin help with depression and other conditions.

Understanding Deplin: The Active Form of Folate

Deplin is a prescription medical food containing L-methylfolate, the active form of folate (vitamin B9). Unlike over-the-counter folic acid supplements, Deplin provides the body with already-activated folate that is ready to be utilized. This crucial difference makes Deplin particularly beneficial for individuals who may have difficulty converting folic acid into its active form.

The Science Behind L-Methylfolate

L-methylfolate plays a vital role in numerous bodily functions, including DNA synthesis, cell division, and the production of neurotransmitters that regulate mood. It is especially important for individuals with certain genetic variations or health conditions that may impair their ability to metabolize folic acid effectively.

• Supports the production of serotonin, dopamine, and norepinephrine
• Aids in the formation of red blood cells
• Contributes to proper nervous system function
• Essential for fetal development during pregnancy

Deplin vs. Over-the-Counter Folic Acid: Key Differences

Why is Deplin different from standard folic acid supplements? The primary distinction lies in the form of folate provided. Over-the-counter folic acid requires activation by the body before it can be utilized. This process involves several enzymatic steps, which can be compromised in some individuals.

Research suggests that up to 70% of people with depression may have difficulty activating folic acid due to genetic variations or other factors. Deplin bypasses this issue by providing L-methylfolate directly, ensuring that the body receives the active form of folate regardless of its ability to convert folic acid.

Advantages of L-Methylfolate Over Folic Acid

• No conversion required by the body
• Immediate bioavailability
• Potentially more effective for individuals with MTHFR gene mutations
• May be better absorbed in conditions affecting folate metabolism

Indications for Deplin: Who Can Benefit?

Deplin is primarily prescribed as an adjunct therapy for individuals with depression, particularly those who have shown a suboptimal response to antidepressant medications. However, its uses extend beyond mood disorders. Healthcare providers may recommend Deplin for various conditions associated with folate deficiency or impaired folate metabolism.

Common Indications for Deplin

1. Major depressive disorder
2. Bipolar depression
3. Schizophrenia (negative symptoms)
4. Peripheral neuropathy
5. Pregnancy (for prevention of neural tube defects)
6. Hyperhomocysteinemia
7. Certain cardiovascular conditions

Can Deplin help with treatment-resistant depression? Some studies suggest that L-methylfolate supplementation may enhance the effectiveness of antidepressants in individuals who have not responded adequately to standard treatments. However, more research is needed to fully establish its efficacy in this context.

Deplin Dosing: Finding the Right Amount

The appropriate dosage of Deplin can vary depending on the individual’s condition, overall health, and specific needs. It is crucial to follow the prescribing physician’s recommendations and not adjust the dose without medical supervision.

Common Deplin Dosages

• 7.5 mg once daily
• 15 mg once daily
• In some cases, doses up to 30 mg daily may be prescribed

How long does it take for Deplin to work? The time frame for experiencing benefits from Deplin can vary. Some individuals may notice improvements within a few weeks, while others may require several months of consistent use. It’s important to maintain open communication with your healthcare provider to assess the effectiveness of the treatment.

Safety Profile and Potential Side Effects

Deplin is generally considered safe when taken as directed. Clinical trials have shown that the side effects of Deplin are comparable to those of a placebo. Unlike traditional antidepressants, Deplin is not associated with common adverse effects such as weight gain, insomnia, or sexual dysfunction.

Possible Side Effects of Deplin

While rare, some individuals may experience mild side effects, including:

• Nausea
• Stomach upset
• Irritability
• Sleep disturbances
• Rash (in rare cases)

Is Deplin safe to take with other medications? Deplin is generally safe to use alongside antidepressants and other medications. However, it’s essential to inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.

Maximizing the Benefits of Deplin Therapy

To get the most out of Deplin supplementation, consider the following tips:

1. Take Deplin consistently at the same time each day
2. Follow a balanced diet rich in folate-containing foods
3. Avoid excessive alcohol consumption, which can interfere with folate metabolism
4. Discuss any changes in your symptoms or side effects with your healthcare provider
5. Continue taking your prescribed antidepressant medication as directed

How can you ensure optimal absorption of Deplin? While Deplin can be taken with or without food, some evidence suggests that taking it with a meal containing healthy fats may enhance absorption. Consult with your healthcare provider for specific recommendations based on your individual needs.

Deplin and Pregnancy: Considerations for Expectant Mothers

Adequate folate intake is crucial during pregnancy to prevent neural tube defects in the developing fetus. While folic acid supplementation is commonly recommended for pregnant women, some may benefit from L-methylfolate supplementation, especially if they have difficulty metabolizing folic acid.

Benefits of L-Methylfolate During Pregnancy

• Reduced risk of neural tube defects
• Support for maternal mood regulation
• Potential reduction in the risk of other congenital abnormalities

Is Deplin safe during pregnancy? While L-methylfolate is generally considered safe during pregnancy, it’s essential to consult with an obstetrician or prenatal care provider before starting any new supplement regimen. They can provide personalized recommendations based on your individual health status and risk factors.

The Role of Deplin in Managing Depression

Depression is a complex disorder that often requires a multifaceted approach to treatment. Deplin may play a valuable role in managing depression, particularly for individuals who have not responded adequately to traditional antidepressant therapies.

How Deplin May Help with Depression

1. Supports the production of neurotransmitters involved in mood regulation
2. May enhance the effectiveness of antidepressant medications
3. Addresses potential folate deficiencies that could contribute to depressive symptoms
4. Provides a non-pharmaceutical option for augmenting depression treatment

Can Deplin be used as a standalone treatment for depression? While Deplin may provide benefits for some individuals, it is typically not recommended as a sole treatment for depression. It is most often used in conjunction with antidepressant medications and other therapeutic approaches.

Accessing Deplin: Prescription and Cost Considerations

Deplin is a prescription medical food, meaning it requires a healthcare provider’s recommendation for use. As it is not classified as a traditional medication, insurance coverage for Deplin can vary.

Options for Obtaining Deplin

• Prescription from a healthcare provider
• Specialty pharmacies
• Brand Direct Health® pharmacy program

How can patients save on Deplin prescriptions? The Brand Direct Health® pharmacy program offers savings, support, and resources to patients prescribed Deplin. This program can help reduce out-of-pocket costs and provide additional assistance in accessing the supplement.

Monitoring and Adjusting Deplin Therapy

Regular follow-up with your healthcare provider is essential when using Deplin. This allows for assessment of the supplement’s effectiveness and any necessary adjustments to the treatment plan.

Factors to Consider During Follow-up Appointments

1. Changes in depressive symptoms
2. Improvements in overall mood and well-being
3. Any side effects or adverse reactions
4. Interactions with other medications or supplements
5. Need for dosage adjustments

How often should Deplin therapy be reassessed? The frequency of follow-up appointments may vary depending on individual circumstances. Initially, more frequent check-ins may be necessary to monitor response and adjust treatment as needed. As therapy stabilizes, less frequent appointments may be appropriate.

Integrating Deplin into a Comprehensive Treatment Plan

While Deplin can be a valuable component of depression treatment, it is most effective when incorporated into a comprehensive approach to mental health. This may include a combination of the following:

• Psychotherapy (e.g., cognitive-behavioral therapy)
• Lifestyle modifications (e.g., regular exercise, stress reduction techniques)
• Traditional antidepressant medications
• Nutritional counseling
• Social support systems

How can patients maximize the benefits of Deplin within a comprehensive treatment plan? Open communication with your healthcare team is crucial. Discuss all aspects of your treatment, including medication, therapy, and lifestyle changes, to ensure a coordinated and effective approach to managing your mental health.

The Future of L-Methylfolate Research and Applications

As our understanding of folate metabolism and its impact on mental health continues to evolve, ongoing research is exploring new potential applications for L-methylfolate supplementation.

Areas of Emerging Research

1. Cognitive function and dementia prevention
2. Autism spectrum disorders
3. Cardiovascular health
4. Inflammatory conditions
5. Cancer prevention and treatment support

What developments can we expect in L-methylfolate supplementation? Future research may lead to more targeted applications of L-methylfolate based on genetic profiles, improved formulations for enhanced bioavailability, and expanded indications for use in various health conditions.

Conclusion: Harnessing the Power of Active Folate

Deplin represents an innovative approach to addressing folate deficiency and supporting mental health. By providing the active form of folate, L-methylfolate, Deplin offers a potential solution for individuals who may not fully benefit from traditional folic acid supplements.

While Deplin has shown promise in managing depression and other conditions associated with folate metabolism, it is essential to approach its use under the guidance of a qualified healthcare provider. As with any medical intervention, the benefits and potential risks should be carefully considered on an individual basis.

As research in this field continues to advance, we may gain further insights into the role of L-methylfolate in various aspects of health and well-being. For now, Deplin remains a valuable tool in the arsenal of treatments available for addressing folate-related health concerns and supporting optimal mental health.

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Product Information

How can DEPLIN

^® help me?

DEPLIN^® can provide the body with already-active folate that is ready to help promote the production of natural chemicals in the brain that affect mood and help you get the most out of your antidepressant therapy.

Is DEPLIN

^® safe? What are the side effects?

Yes, DEPLIN^® is generally safe and does not have the side effects of traditional antidepressants. In clinical trials, the side effects of DEPLIN^® were about the same as those of a placebo (a pill or liquid with no active medicine, such as a sugar pill). DEPLIN^®, which is safe to take with antidepressant medications when taken as indicated, is not associated with weight gain, insomnia, or sexual dysfunction.

How is DEPLIN

^® different from over-the-counter (OTC) options?

OTC folic acid needs to be activated by your body before it can be used. Unfortunately, up to 70% of people with depression may have a compromised ability to complete this activation. DEPLIN^® capsules can provide you with already-active folate so your body does not have to activate it for you to see a benefit. DEPLIN^® addresses the body’s nutritional requirements and creates an environment that allows you to get the most out of your antidepressant therapy.

Is there a program to help me save on my prescription?

Yes, you can save on DEPLIN^® with Brand Direct Health^® pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health^® pharmacy, call 1-866-331-6440 or visit www.branddirecthealth.com to learn more.

Symptoms of depression can include:

• Sadness
• Loss of interest or pleasure in activities you used to enjoy
• Change in weight/appetite
• Difficulty sleeping or oversleeping
• Low concentration/Trouble making decisions
• Energy loss/Feeling slowed down
• Feelings of worthlessness
• Thoughts of death or suicide

Adapted from the MedlinePlus website.

Deplin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Folic acid is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.Folic acid supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of folic acid either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Deplin

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Folic acid usually has very few side effects. If you have any unusual effects from taking this product, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this product, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this product do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this product, tell your doctor or pharmacist your medical history, especially of: vitamin B-12 deficiency (pernicious anemia).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Folic acid is safe to take during pregnancy when used as directed. It is included in prenatal vitamin products. Certain spinal cord birth defects may be prevented by taking adequate amounts of folic acid during pregnancy. Consult your doctor for more details.

Folic acid passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Deplin interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: mental/mood changes.

Do not share this medication with others.

Lab and/or medical tests (such as complete blood count, folate blood level, vitamin B-12 blood level) should be done while you are taking this product. Keep all medical and lab appointments. Consult your doctor for more details.

Folate is naturally found in leafy green vegetables, organ meats (liver, kidney), citrus fruits, and other foods. Folic acid is added to enriched grain products such as bread, pasta, and cereal. Consult your doctor or dietician for a diet plan rich in folate/folic acid.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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instructions for use, dosages, composition, analogues, side effects / Pillintrip

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Page reviewed by pharmacist Fedorchenko Olga Valerievna Last update 2022-03-12

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The information on this page is for healthcare professionals only!
The information is collected from open sources and may contain significant errors!
Be careful and double-check all the information on this page!

Top 20 drugs with the same ingredients:

Gyno-TardyferonFolbiolFerronemiaFolicilFysiofolBialferFolavitMaltofer FolMaterfolFeofolFolicronTardyferon FolFefolFolimenUniferolFolic AcidFolviteGyno TardyferonFolasHuma-Folaci d

Top 20 drugs with the same use:

Maxifol 5000FolsanHBHHAcide Folique ArrowFegemFol LichtensteinFolacFolivitalPediafolicFolsäure-ratiopharmAcfolAcide Folique CCDAndreafolFilicineAcido Folico A. M.AcifolFolaci dFolic Acid-Tsiteli AFolimaxFolin

Name of the drug

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Deplin

Composition

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Therapeutic Indications

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folate deficiency anemia;

Hypo- and avitaminosis of folic acid (including with tropical sprue, celiac disease, malnutrition).

treatment and prevention of folic acid deficiency due to unbalanced or malnutrition;

treatment and prevention of anemia due to folic acid deficiency: macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, postresection anemia, sideroblastic anemia in the elderly, anemia associated with diseases of the small intestine, sprue and malabsorption syndrome ;

treatment and prevention of anemia during pregnancy and lactation;

during pregnancy – prevention of the development of neural tube defects in the fetus;

long-term treatment with folic acid antagonists (methotrexate, a combination of sulfamethoxazole and trimethoprim), anticonvulsants (phenytoin, primidone, phenobarbital).

Dosage and Administration

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Int.

Folate deficiency anemia: adults and children of any age starting dose – 1 mg / day. At high doses, resistance may occur.

Maintenance treatment: neonatal 0.1 mg/day; for children under 4 years old – 0.3 mg / day; for children over 4 years old and adults – 0.4 mg / day; during pregnancy and lactation – from 0.1 to 0. 8 mg / day.

With hypo- and avitaminosis of folic acid (depending on the severity of avitaminosis): adults – up to 5 mg / day; children – in smaller doses depending on age. The course of treatment is 20-30 days.

With concomitant alcoholism, hemolytic anemia, chronic infectious diseases, after gastrectomy, malabsorption syndrome, liver failure, liver cirrhosis, stress, the dose of the drug should be increased to 5 mg / day.

Treatment of megaloblastic anemia due to folic acid deficiency – 5 mg / day for 4 months, prevention – 2.5 mg / day.

Prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel disease and unbalanced or malnutrition – 15 mg / day, in patients with sprue – 5-15 mg / day.

Prevention of the development of neural tube defects in the fetus – 2.5 mg / day for 4 weeks before the expected pregnancy, continue taking it during the first trimester of pregnancy.

Higher maintenance doses may be given to patients suffering from alcoholism, as well as to patients with chronic infections and taking anticonvulsants.

Contraindications

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hypersensitivity to drug components;

B ₁₂ – deficiency anemia;

sucrase deficiency;

isomaltase deficiency;

fructose intolerance;

glucose-galactose malabsorption;

children’s age (up to 3 years).

Precautions: folate deficiency anemia with cyanocobalamin deficiency.

hypersensitivity to drug components;

pernicious anemia;

malignant neoplasms;

cobalamin deficiency.

Adverse effects

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Allergic reactions – skin rash, pruritus, bronchospasm, erythema, hyperthermia.

Allergic reactions: possible development of skin rashes, itching, erythema, bronchospasm.

From the gastrointestinal tract: anorexia, nausea, bloating, bitterness in the mouth.

Overdose

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Doses of folic acid up to 4–5 mg are well tolerated. Higher doses may cause CNS and GI disturbances.

No cases of overdose have been reported.

Pharmacodynamics

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Vitamin B group (vitamin B _c , vitamin B ₉ ), can be synthesized and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine.

Vitamin B. In the body it is converted into tetrahydrofolic acid, which is involved in various metabolic processes as a coenzyme and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. With a deficiency of folic acid, a megaloblastic type of hematopoiesis develops. Stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine. During pregnancy, it performs a protective function in relation to the action of teratogenic and fetal-damaging factors. Contributes to the normal maturation and functioning of the placenta.

Pharmacokinetics

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Folic acid is well and completely absorbed in the gastrointestinal tract, mainly in the upper duodenum (even in the presence of malabsorption syndrome against the background of tropical sprue).

Intensively binds to plasma proteins. Penetrates through the BBB, the placenta, and also into breast milk. T _max – 30-60 min. It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase).

Excreted by the kidneys mainly as metabolites. If the accepted dose significantly exceeds the daily requirement for folic acid, then it is excreted unchanged.

Eliminated by hemodialysis.

After oral administration, folic acid, combining in the stomach with the internal factor of Castle (a specific glycoprotein), is well and completely absorbed in the gastrointestinal tract. Almost completely bound to plasma proteins.

Deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of the enzyme dihydrofolate reductase). Penetrates through the BBB, the placenta and into breast milk. C _max in the blood is achieved in 30–60 minutes. It is excreted by the kidneys both unchanged (if the accepted dose significantly exceeds the daily requirement), and in the form of metabolites. Excreted by hemodialysis. 5 mg of folic acid taken orally is excreted from the body after 5 hours.0072 . Be
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Anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.

Antacids (including calcium, aluminum and magnesium preparations), cholestyramine, sulfonamides (including sulfasalazine) reduce the absorption of folic acid.

Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (calcium folinate should be given instead in patients using these drugs).

There is no definitive information regarding zinc preparations: some studies show that folate inhibits zinc absorption, others do not.

When used simultaneously with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid is reduced.

With simultaneous use, folic acid reduces the effects of oral contraceptives, ethanol, sulfasalazine, cycloserine and glutethimide, methotrexate, phenytoin, primidone, chloramphenicol.

Folic acid may decrease plasma levels of phenobarbital, phenytoin, or primidone and cause an epileptic seizure.

Decreased or altered absorption may occur with co-administration of cholestyramine and folic acid, so folic acid should be taken 1 hour before or 4 to 6 hours after cholestyramine.

Pharmacological group

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• Hemopoiesis stimulants
• Vitamins and vitamin-like preparations

• Vitamin; hematopoiesis stimulator [Hematopoiesis stimulants]
• Vitamin; hematopoiesis stimulant [Vitamins and vitamin-like products]

Deplin price

We don’t have exact price data for this medicine.
However, we will provide data for each active ingredient

The average cost of Folic Acid 5 mg per unit in online pharmacies is from $0.25 to $0.84, per package from $25 to $92.

The average cost of Folic Acid 1 mg per unit in online pharmacies is from $0.21 to $0.21, per package from $21 to $21.

Sources:

• https://www.drugs.com/mtm/deplin.html
• https://pubmed.ncbi.nlm.nih.gov/?term=deplin

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Deplin (L-Methylfolate [from Metafolin] and Algae-S Powder [Schizochytrium] Therapeutic Nutrition Prescription): Uses, Dosage, Side Effects, Interactions, Warning

Full

• Generic Name: l-methylfolate [from metafolin] and seaweed powder [schizophrenia] Prescription Health Nutrition
• Brand Name: Complete

• Product description
• Indications and dosage
• Side effects and drug interactions
• Warnings and precautions
• Overdose and contraindications
• Clinical pharmacology
• Medication Guide

Product Description

FULL 7. 5 capsules

FULL 15 capsules

DESCRIPTION

DEPLIN is a prescription medical food for use only under the supervision of a physician for the clinical dietary treatment of depression and schizophrenia and is specifically formulated to meet the specific nutritional requirements of these conditions.

Each DEPLIN 7.5 capsule contains 7.5 mg of L-methylfolate (from Metafolin) and 90.314 mg of Algae-S powder (Schizochytrium). CAS No. 151533-22-1

Each DEPLIN 15 capsule contains 15.0 mg of L-methylfolate (from Metafolin) and 90.314 mg Algae-S powder (Schizochytrium). CAS No. 151533-22-1

how much milk thistle per day

Ingredients

COMPLETE 7.5

Silicified Microcrystalline Cellulose, Algae-S Powder (Schizochytrium Algae Oil [vegetable source], Glucose Syrup Solids, Mannitol, Sodium Caseinate (Milk), Soy Protein, High Oleic Sunflower Oil, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate, natural flavors, soy lecithin, and a mixture of natural tocopherols and ascorbyl palmitate [as antioxidants]), Pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source), FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, FD&C Yellow #6 Aluminum Lake, Shellac. Contains milk and soy

FULL 15

Siliconized microcrystalline cellulose, Algae-S powder (Schizochytrium algae oil [vegetable source], glucose syrup solids, mannitol, sodium caseinate (milk), soy protein, high sunflower oil oleic acid, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate Natural flavors, soy lecithin and mixed natural tocopherols and ascorbyl palmitate [as antioxidants]), pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source) )], FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, shellac. Contains milk and soy

DEPLIN is a medical prescription food for use only under medical supervision.

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Medical foods are intended for patients who have a limited or impaired ability to take in, digest, absorb, or metabolize common foods or certain nutrients, or who have other special medical nutritional requirements for which dietary regulation cannot be achieved by modifications. just a normal diet. ¹ This product is not an Orange Book product.

RECOMMENDATIONS

1. US Food and Drug Administration 21 CFR 101.9(j)(8).

Adverse effects and drug interactions

SIDE EFFECTS

Allergic reactions have been reported following oral administration of L-methylfolate. ¹¹

DRUG INTERACTIONS

Information not provided

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RECOMMENDATIONS

11. Natural Standards Collaboration (NIH). Folate (Folic Acid) 2009 Monograph.

PRECAUTIONS

General

L-methylfolate (DEPLIN) is not interchangeable with folic acid. In some patients, folic acid is not effective in influencing folic acid levels in the brain due to the low rate of transport of folic acid across the blood-brain barrier and/or low levels in the brain of an enzyme needed to convert folic acid into a biological and functional form. ^7-9

Patients at risk of vitamin B12 deficiency should consult their physician before taking L-methylfolate.