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Deplin dosing. Deplin (L-methylfolate): Comprehensive Guide to Dosing, Indications, and Effects

by alexxlab

What is Deplin and how does it work. How is Deplin different from over-the-counter folic acid. What are the potential side effects and interactions of Deplin. How can patients save money on Deplin prescriptions.

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Understanding Deplin: A Unique Form of Folate

Deplin is a prescription medical food containing L-methylfolate, the active form of folate (vitamin B9). Unlike over-the-counter folic acid supplements, Deplin provides already-activated folate that the body can immediately utilize. This distinction is particularly crucial for individuals with depression or certain genetic variations that may impair their ability to convert folic acid into its active form.

The Science Behind Deplin

L-methylfolate, the active ingredient in Deplin, plays a vital role in the production of neurotransmitters that regulate mood, such as serotonin, dopamine, and norepinephrine. By providing this readily available form of folate, Deplin aims to support optimal brain function and enhance the effectiveness of antidepressant medications.

Indications and Uses of Deplin

Deplin is primarily indicated as an adjunctive therapy for individuals with depression. It may be particularly beneficial for patients who have not responded adequately to traditional antidepressant treatments. Additionally, Deplin may be prescribed to address folate deficiencies in various conditions:

  • Major depressive disorder
  • Certain types of anemia
  • Pregnancy (to prevent neural tube defects)
  • Alcoholism
  • Liver disease
  • Kidney dialysis patients
  • Individuals with MTHFR gene mutations

Deplin Dosing Guidelines and Administration

The appropriate dosage of Deplin can vary depending on the individual’s specific condition and needs. However, typical dosing guidelines include:

  • Standard dose: 7.5 mg or 15 mg once daily
  • Administration: Taken orally, with or without food
  • Timing: Consistently at the same time each day for optimal results

How should Deplin be taken? Deplin should be taken exactly as prescribed by your healthcare provider. It’s important to maintain a consistent dosing schedule and not exceed the recommended amount without consulting your doctor.

Deplin vs. Over-the-Counter Folic Acid: Key Differences

Understanding the distinction between Deplin and standard folic acid supplements is crucial for patients and healthcare providers alike. Here are the primary differences:

  1. Active form: Deplin contains L-methylfolate, which is immediately bioavailable, while folic acid requires conversion by the body.
  2. Absorption: Up to 70% of individuals with depression may have difficulty activating folic acid, making Deplin potentially more effective.
  3. Dosage: Deplin typically provides higher doses of active folate compared to OTC supplements.
  4. Prescription status: Deplin is a prescription medical food, while folic acid is available over-the-counter.

Why might Deplin be more effective than OTC folic acid for some individuals? The key lies in its active form, which bypasses the need for enzymatic conversion in the body, potentially benefiting those with genetic variations or conditions that impair folate metabolism.

Potential Side Effects and Safety Considerations

Deplin is generally well-tolerated, with clinical trials showing side effect profiles similar to placebo. However, as with any medical intervention, some individuals may experience adverse effects:

  • Nausea
  • Irritability
  • Sleep disturbances
  • Skin reactions (rare)

Is Deplin safe to take with antidepressants? Yes, Deplin is considered safe to use in conjunction with antidepressant medications when taken as directed. Unlike traditional antidepressants, Deplin is not associated with common side effects such as weight gain, insomnia, or sexual dysfunction.

Allergic Reactions

While rare, severe allergic reactions to Deplin can occur. Patients should seek immediate medical attention if they experience symptoms such as:

  • Rash or hives
  • Itching or swelling, especially of the face, tongue, or throat
  • Severe dizziness
  • Difficulty breathing

Drug Interactions and Precautions

While Deplin is generally safe, it’s essential to consider potential interactions with other medications or supplements:

  • Anticonvulsants: May reduce folate levels
  • Methotrexate: May interfere with its effectiveness
  • Antibiotics: Certain types may reduce folate absorption
  • Proton pump inhibitors: Long-term use may affect folate levels

Should patients disclose all medications and supplements to their healthcare provider before starting Deplin? Absolutely. It’s crucial to provide a complete medical history and list of current medications to ensure safe and effective treatment.

Cost Considerations and Patient Assistance Programs

As a prescription medical food, Deplin may not be covered by all insurance plans, potentially leading to higher out-of-pocket costs for some patients. However, there are options available to help manage these expenses:

  • Brand Direct Health® pharmacy: Offers savings, support, and resources for patients
  • Manufacturer coupons or rebates: May be available through the official Deplin website
  • Patient assistance programs: Some pharmaceutical companies offer programs to help eligible patients access medications at reduced costs

How can patients access cost-saving options for Deplin? Patients can contact Brand Direct Health® pharmacy at 1-866-331-6440 or visit their website at www.branddirecthealth.com to learn more about available savings programs and resources.

The Role of Deplin in Depression Management

Depression is a complex mental health condition that can significantly impact an individual’s quality of life. Deplin may play a valuable role in comprehensive depression treatment by addressing potential folate deficiencies and supporting neurotransmitter production. Common symptoms of depression that Deplin may help address include:

  • Persistent sadness or low mood
  • Loss of interest in previously enjoyed activities
  • Changes in appetite or weight
  • Sleep disturbances
  • Difficulty concentrating or making decisions
  • Fatigue or loss of energy
  • Feelings of worthlessness or excessive guilt
  • Recurrent thoughts of death or suicide

Can Deplin be used as a standalone treatment for depression? While Deplin can be an effective adjunctive therapy, it is typically not recommended as a standalone treatment for depression. A comprehensive approach, including psychotherapy, lifestyle modifications, and possibly traditional antidepressants, is often necessary for optimal management of depressive disorders.

Enhancing Antidepressant Efficacy

One of the primary benefits of Deplin is its potential to enhance the effectiveness of traditional antidepressant medications. By providing the body with readily available L-methylfolate, Deplin may help create an optimal environment for antidepressants to work more effectively, potentially leading to improved treatment outcomes.

Genetic Considerations: The MTHFR Connection

The methylenetetrahydrofolate reductase (MTHFR) gene plays a crucial role in folate metabolism. Genetic variations in this gene can affect an individual’s ability to convert folic acid into its active form, L-methylfolate. This genetic factor may explain why some individuals respond poorly to traditional folic acid supplements and may benefit more from Deplin.

MTHFR Genetic Testing

In some cases, healthcare providers may recommend genetic testing to identify MTHFR mutations. This information can help guide treatment decisions and determine whether a patient might be a good candidate for Deplin supplementation.

Is genetic testing necessary before starting Deplin? While genetic testing can provide valuable information, it is not always required before prescribing Deplin. The decision to test for MTHFR mutations should be made on an individual basis in consultation with a healthcare provider.

Deplin in Pregnancy and Fetal Development

Adequate folate intake is critical during pregnancy, particularly in the early stages, to prevent neural tube defects in developing fetuses. While folic acid supplementation is commonly recommended for pregnant women, some may benefit from the active form of folate found in Deplin, especially if they have difficulty metabolizing folic acid.

Considerations for Pregnant Women

  • Consult with a healthcare provider before starting or continuing Deplin during pregnancy
  • Discuss the potential benefits and risks of Deplin compared to standard folic acid supplementation
  • Consider genetic factors, such as MTHFR mutations, that may influence folate metabolism

Can Deplin replace standard prenatal vitamins? Deplin should not be considered a replacement for comprehensive prenatal vitamins. It may be prescribed in addition to prenatal supplements in certain cases, but this decision should be made under the guidance of a healthcare provider.

Monitoring and Follow-up Care

Regular monitoring and follow-up care are essential components of Deplin therapy. Healthcare providers may recommend:

  • Periodic blood tests to assess folate levels and overall health
  • Regular check-ins to evaluate symptom improvement and potential side effects
  • Adjustments to dosage or treatment plan as needed
  • Coordination with other healthcare providers involved in the patient’s care

How often should patients follow up with their healthcare provider while taking Deplin? The frequency of follow-up appointments may vary depending on individual circumstances, but typically, patients should have regular check-ins, especially in the initial months of treatment, to ensure optimal response and address any concerns.

Lifestyle Factors and Deplin Efficacy

While Deplin can be an effective component of depression treatment, its efficacy may be influenced by various lifestyle factors. Patients may maximize the benefits of Deplin by incorporating the following strategies:

  • Maintaining a balanced diet rich in folate-containing foods
  • Regular exercise to support overall mental health
  • Stress management techniques, such as meditation or mindfulness practices
  • Adequate sleep hygiene
  • Limiting alcohol consumption, which can interfere with folate absorption
  • Avoiding smoking, which may affect folate levels

Can lifestyle modifications enhance the effectiveness of Deplin? Yes, adopting healthy lifestyle habits can potentially improve the overall response to Deplin and other depression treatments. A holistic approach that combines medication, therapy, and positive lifestyle changes often yields the best results in managing depression and related conditions.

Future Directions and Ongoing Research

As the understanding of folate metabolism and its role in mental health continues to evolve, ongoing research is exploring new applications and potential benefits of L-methylfolate supplementation. Areas of current investigation include:

  • The role of Deplin in treating other psychiatric disorders, such as bipolar depression and schizophrenia
  • Potential neuroprotective effects in neurodegenerative diseases
  • Optimization of dosing strategies for different patient populations
  • Long-term safety and efficacy studies
  • Combination therapies involving Deplin and other nutraceuticals

What new developments can patients expect in the field of L-methylfolate supplementation? As research progresses, patients may see expanded indications for Deplin, more personalized treatment approaches based on genetic profiles, and potentially new formulations or delivery methods for L-methylfolate.

Staying Informed

Patients and healthcare providers alike should stay informed about the latest developments in L-methylfolate research and its applications in mental health treatment. This can be achieved through:

  • Regular consultations with healthcare providers
  • Following reputable medical journals and health news sources
  • Participating in patient education programs or support groups
  • Engaging with mental health advocacy organizations

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Product Information


How can DEPLIN

® help me?

DEPLIN® can provide the body with already-active folate that is ready to help promote the production of natural chemicals in the brain that affect mood and help you get the most out of your antidepressant therapy.

Is DEPLIN

® safe? What are the side effects?

Yes, DEPLIN® is generally safe and does not have the side effects of traditional antidepressants. In clinical trials, the side effects of DEPLIN® were about the same as those of a placebo (a pill or liquid with no active medicine, such as a sugar pill). DEPLIN®, which is safe to take with antidepressant medications when taken as indicated, is not associated with weight gain, insomnia, or sexual dysfunction.

How is DEPLIN

® different from over-the-counter (OTC) options?

OTC folic acid needs to be activated by your body before it can be used. Unfortunately, up to 70% of people with depression may have a compromised ability to complete this activation. DEPLIN® capsules can provide you with already-active folate so your body does not have to activate it for you to see a benefit. DEPLIN® addresses the body’s nutritional requirements and creates an environment that allows you to get the most out of your antidepressant therapy.

Is there a program to help me save on my prescription?

Yes, you can save on DEPLIN® with Brand Direct Health® pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health® pharmacy, call 1-866-331-6440 or visit www.branddirecthealth.com to learn more.

Symptoms of depression can include:

  • Sadness

  • Loss of interest or pleasure in activities you used to enjoy

  • Change in weight/appetite

  • Difficulty sleeping or oversleeping

  • Low concentration/Trouble making decisions

  • Energy loss/Feeling slowed down

  • Feelings of worthlessness

  • Thoughts of death or suicide

Adapted from the MedlinePlus website.

Deplin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Folic acid is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.Folic acid supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of folic acid either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Deplin

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Folic acid usually has very few side effects. If you have any unusual effects from taking this product, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this product, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this product do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this product, tell your doctor or pharmacist your medical history, especially of: vitamin B-12 deficiency (pernicious anemia).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Folic acid is safe to take during pregnancy when used as directed. It is included in prenatal vitamin products. Certain spinal cord birth defects may be prevented by taking adequate amounts of folic acid during pregnancy. Consult your doctor for more details.

Folic acid passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Deplin interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: mental/mood changes.

Do not share this medication with others.

Lab and/or medical tests (such as complete blood count, folate blood level, vitamin B-12 blood level) should be done while you are taking this product. Keep all medical and lab appointments. Consult your doctor for more details.

Folate is naturally found in leafy green vegetables, organ meats (liver, kidney), citrus fruits, and other foods. Folic acid is added to enriched grain products such as bread, pasta, and cereal. Consult your doctor or dietician for a diet plan rich in folate/folic acid.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Fitmin Dog Purity Rice Senior, Light Venison, Lamb 2 Kg

Delivery in Chisinau – 40 lei, Free from 350 lei.

Delivery in Chisinau is carried out from Monday to Friday from 10:00 to 22:00, on Saturday from 10:00 to 18:00.

Orders received on weekdays before 14:00 are delivered on the same day, after 14:00 are delivered the next day.

Orders received on Saturday before 12:00 are delivered on the same day, and after 12:00 are delivered on Monday.

Self-delivery of goods is possible by prior agreement at the address: Chisinau, st. Grigore Ureke 14, of. 58

* Express delivery within 2 hours – 95 lei.

Attention!

Orders for delivery within 2 hours are accepted until 14:00!

– Please note that after you place an order, we need some time to process, check and deliver the feed; these operations, as a rule, take no more than 24 hours from the moment of receipt of the application.

– Our operator will contact you and discuss a convenient delivery time for you.

– The courier will call you 30 minutes before the delivery of the goods.

– Delivery is carried out only for the goods registered in the application. Transportation of several goods, in order to select one of them on the spot, is not performed.

You are kindly requested! Check the compliance of the order, the deadlines for implementation, the integrity of the packaging in the presence of the courier!

*** The buyer has the right to return the order to the courier if a marriage or incorrect packaging is found only if the order was checked in the presence of the courier (i. e. upon receipt on the spot).

When choosing dry food by weight, pay attention to the needs of your animal. DRY FOOD SOLD BY WEIGHT IS NOT AVAILABLE FOR EXCHANGE AND REFUND!

– We deliver directly to the door of your home or office. Lift access is free of charge.

– Free of charge without an elevator up to and including the 3rd floor,

if lifting is required from 20 kg above the 3rd floor (without an elevator), each lift is paid – 10 lei for each floor after the third (or you can lift it yourself).
If the courier needs to go up to the floor several times, in case when the entire order of the client did not fit into the hands of the courier at one time, it will be necessary to pay 10 lei for each climb for each floor above 3!

– If there is paid parking or paid entrance to the territory of an office, residential area, enterprise, delivery is carried out only to the place of entry to the paid territory. If it is necessary to enter the protected area, the buyer must ensure the unimpeded entry of the car, take care of the pass in advance.

Payment for goods is made in cash or by bank card to the courier on the spot, as well as payment by Online Mastercard Visa

Delivery to the regions of Moldova within 72 hours – paid for any type of goods. Delivery to the regions is calculated individually. Check with operators.

Delivery Cost Is 40 lei from the order amount over 350 lei and 60 lei from the order amount below 350 lei to the following regions:

* Airport

* Bubuieci

* Bull

* Vatra

* Gratiesti

* Gidigich

* Keltuitor

* Colonica

* Placed

* Togatino, Poiana Nucului

Order Cost Is 50 lei from any order amount:

* Bach oh

* Cricova

to Frumushika, Straisteny – 70 lei

Delivery to Balcata, Budesti, Braila, Dencheni, Trusheni – 80 lei

Delivery to Cojusna, Sirets – 90 lei

Delivery to Bardar, Singera, Suruceni – 100 lei

Delivery to Dobruja – 120 lei

Delivery to Straseni, Vadul-lui-Voda – 140 lei

Delivery to Condrita – 220 lei

Delivery to Orhei – 220 lei 9000 4

Delivery to customs Varnitsa – 200 lei

PRINCIPALA

Adult age/weight 1.5 – 2.5 kg 2.5 – 5 kg 5-10 kg 10-15 kg 15-20 kg 20-30 kg 30-40 kg 40-50 kg 50-60 kg 60 – 70 kg 70 – 80 kg
adult dog – elderly 35 – 45 g 40 – 80 g 70 – 150 g 140 – 200 g 190 – 260 g 240 – 360 g 340-460 g 440 – 540 g 510-620 g 590-700 g 670-780 g
adult dog – fat 30-40 g 35 – 75 g 65 – 135 g 125 – 190 g 180 – 240 g 230 – 320 g 300-410 g 400 – 490 g 460 – 560 g 530-630 g 600-700 g