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Deplin Dosing: L-Methylfolate for Depression and Folate Deficiency

by alexxlab

What is Deplin and how does it work. How is Deplin different from over-the-counter folic acid. What are the potential side effects and interactions of Deplin. How should Deplin be dosed for depression and folate deficiency. Who may benefit most from taking Deplin.

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Understanding Deplin: A Prescription Form of L-Methylfolate

Deplin is a prescription medical food containing L-methylfolate, the active form of folate (vitamin B9). Unlike over-the-counter folic acid supplements, Deplin provides already-activated folate that can be readily utilized by the body. This makes it particularly useful for individuals who have difficulty converting folic acid to its active form.

Key Features of Deplin:

  • Contains L-methylfolate, the biologically active form of folate
  • Bypasses the need for enzymatic conversion in the body
  • Prescribed as an adjunct to antidepressant therapy
  • May help address nutritional deficiencies associated with depression

The Role of Folate in Mental Health

Folate plays a crucial role in various bodily functions, including the production of neurotransmitters that regulate mood. Inadequate folate levels have been linked to an increased risk of depression and may reduce the effectiveness of antidepressant medications.

Can folate deficiency contribute to depression? Research suggests that low folate levels are more common in individuals with depression compared to the general population. Addressing this deficiency may help improve treatment outcomes for some patients.

Deplin vs. Over-the-Counter Folic Acid Supplements

While both Deplin and over-the-counter folic acid supplements aim to increase folate levels in the body, there are significant differences between the two:

Deplin (L-methylfolate):

  • Already in its active form
  • Does not require enzymatic conversion
  • May be more effective for individuals with MTHFR gene mutations
  • Prescribed as a medical food

Over-the-Counter Folic Acid:

  • Synthetic form of folate
  • Requires enzymatic conversion in the body
  • Less expensive and widely available
  • Suitable for general supplementation and pregnancy

Why might Deplin be more effective than folic acid for some individuals? Up to 70% of people with depression may have a compromised ability to convert folic acid to its active form due to genetic variations or other factors. Deplin provides the active form directly, potentially offering greater benefits for these individuals.

Indications for Deplin Use

Deplin is primarily prescribed as an adjunctive therapy for individuals with depression, particularly those who have not responded adequately to antidepressant medication alone. It may also be used in other situations where folate deficiency is suspected or confirmed.

Common indications for Deplin include:

  1. Major depressive disorder (as an adjunct to antidepressants)
  2. Treatment-resistant depression
  3. Folate deficiency due to genetic factors (e.g., MTHFR mutations)
  4. Conditions that impair folate absorption or metabolism
  5. Pregnancy (for women with a history of neural tube defects)

Do all patients with depression require Deplin? Not necessarily. Deplin is typically considered when standard antidepressant therapy has not produced satisfactory results or when there is reason to suspect impaired folate metabolism.

Dosing Guidelines for Deplin

The appropriate dosage of Deplin can vary depending on the individual’s needs and the condition being treated. Always follow your healthcare provider’s instructions regarding dosing.

Typical Deplin dosing for depression:

  • 7.5 mg to 15 mg once daily
  • Some patients may require higher doses of up to 30 mg daily
  • Dosage adjustments may be made based on response and tolerability

How long does it take for Deplin to work? While some patients may notice improvements within a few weeks, it can take up to 8-12 weeks to experience the full benefits of Deplin when used as an adjunct to antidepressant therapy.

Potential Side Effects and Safety Considerations

Deplin is generally well-tolerated, with a safety profile similar to that of a placebo in clinical trials. However, as with any medication, some individuals may experience side effects.

Possible side effects of Deplin:

  • Nausea
  • Stomach upset
  • Allergic reactions (rare)
  • Sleep disturbances (uncommon)

Is Deplin associated with the same side effects as antidepressants? Unlike many traditional antidepressants, Deplin is not typically associated with weight gain, sexual dysfunction, or insomnia. This may make it a favorable option for patients concerned about these common antidepressant side effects.

Drug Interactions and Precautions

While Deplin has fewer drug interactions compared to many medications, it’s essential to be aware of potential interactions and take necessary precautions.

Potential interactions to consider:

  • Methotrexate: May increase the risk of methotrexate toxicity
  • Anticonvulsants: May reduce the effectiveness of certain anticonvulsant medications
  • Vitamin B12 deficiency: L-methylfolate may mask the symptoms of B12 deficiency

Should patients stop taking other supplements when using Deplin? It’s important to inform your healthcare provider about all supplements and medications you’re taking. In some cases, adjustments to your supplement regimen may be necessary to avoid excessive folate intake.

Monitoring and Adjusting Deplin Therapy

Regular monitoring is essential to ensure the effectiveness and safety of Deplin therapy. Your healthcare provider may recommend periodic assessments to evaluate your response to treatment and make any necessary adjustments.

Factors to consider during Deplin therapy:

  1. Symptom improvement
  2. Tolerability and side effects
  3. Folate and homocysteine levels
  4. Interaction with other medications
  5. Overall treatment response

How often should patients follow up with their healthcare provider while taking Deplin? The frequency of follow-up appointments may vary, but typically, patients should have regular check-ins every 4-8 weeks during the initial phase of treatment, with less frequent visits once stable improvement is achieved.

Deplin and Pregnancy: Special Considerations

Folate supplementation is crucial during pregnancy to reduce the risk of neural tube defects in the developing fetus. For women with a history of neural tube defects or those who have difficulty metabolizing folic acid, Deplin may be prescribed as an alternative to standard prenatal vitamins.

Key points regarding Deplin use during pregnancy:

  • May be prescribed for women with MTHFR mutations
  • Can help ensure adequate folate levels for fetal development
  • Should be used under the guidance of a healthcare provider
  • May be used in conjunction with other prenatal supplements

Is Deplin safe for use during breastfeeding? While L-methylfolate is generally considered safe during lactation, it’s essential to consult with your healthcare provider to determine the appropriate dosage and monitor for any potential effects on the infant.

Accessing and Affording Deplin

As a prescription medical food, Deplin may not be covered by all insurance plans. However, there are options available to help patients access and afford this medication.

Options for obtaining Deplin:

  1. Prescription from a healthcare provider
  2. Brand Direct Health pharmacy program
  3. Manufacturer savings programs or coupons
  4. Patient assistance programs for eligible individuals

How can patients save on their Deplin prescription? The Brand Direct Health pharmacy program offers savings, support, and resources to patients prescribed Deplin. To learn more or fill a prescription through this program, patients can call 1-866-331-6440 or visit the Brand Direct Health website.

The Future of Folate Supplementation in Mental Health

As research in the field of nutritional psychiatry continues to evolve, the role of folate and other nutrients in mental health treatment is gaining increased attention. Deplin and similar L-methylfolate products represent a growing trend towards personalized, targeted nutritional interventions for mental health disorders.

Emerging areas of research:

  • Genetic testing to identify individuals who may benefit most from L-methylfolate supplementation
  • Combination therapies involving L-methylfolate and other nutraceuticals
  • The potential role of L-methylfolate in preventing cognitive decline
  • Investigating L-methylfolate’s effects on other mental health conditions beyond depression

What does the future hold for folate-based interventions in mental health? As our understanding of the complex interplay between nutrition and mental health grows, we may see more targeted, personalized approaches to folate supplementation based on individual genetic profiles and specific mental health needs.

Conclusion: Deplin as a Valuable Tool in Depression Management

Deplin offers a unique approach to addressing folate deficiency and supporting antidepressant therapy in individuals with depression. By providing the active form of folate, it may help improve treatment outcomes for patients who have not responded adequately to standard interventions alone.

While Deplin is generally safe and well-tolerated, it’s essential to use this medical food under the guidance of a healthcare provider. Regular monitoring and open communication about symptoms, side effects, and overall well-being are crucial for optimizing the benefits of Deplin therapy.

As research in nutritional psychiatry continues to advance, Deplin and similar L-methylfolate products may play an increasingly important role in the comprehensive management of depression and other mental health disorders. By addressing underlying nutritional deficiencies, these interventions have the potential to enhance the effectiveness of traditional treatments and improve overall mental health outcomes for many individuals.

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How can DEPLIN

® help me?

DEPLIN® can provide the body with already-active folate that is ready to help promote the production of natural chemicals in the brain that affect mood and help you get the most out of your antidepressant therapy.

Is DEPLIN

® safe? What are the side effects?

Yes, DEPLIN® is generally safe and does not have the side effects of traditional antidepressants. In clinical trials, the side effects of DEPLIN® were about the same as those of a placebo (a pill or liquid with no active medicine, such as a sugar pill). DEPLIN®, which is safe to take with antidepressant medications when taken as indicated, is not associated with weight gain, insomnia, or sexual dysfunction.

How is DEPLIN

® different from over-the-counter (OTC) options?

OTC folic acid needs to be activated by your body before it can be used. Unfortunately, up to 70% of people with depression may have a compromised ability to complete this activation. DEPLIN® capsules can provide you with already-active folate so your body does not have to activate it for you to see a benefit. DEPLIN® addresses the body’s nutritional requirements and creates an environment that allows you to get the most out of your antidepressant therapy.

Is there a program to help me save on my prescription?

Yes, you can save on DEPLIN® with Brand Direct Health® pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health® pharmacy, call 1-866-331-6440 or visit www.branddirecthealth.com to learn more.

Symptoms of depression can include:

  • Sadness

  • Loss of interest or pleasure in activities you used to enjoy

  • Change in weight/appetite

  • Difficulty sleeping or oversleeping

  • Low concentration/Trouble making decisions

  • Energy loss/Feeling slowed down

  • Feelings of worthlessness

  • Thoughts of death or suicide

Adapted from the MedlinePlus website.

Deplin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Folic acid is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.Folic acid supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of folic acid either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Deplin

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Folic acid usually has very few side effects. If you have any unusual effects from taking this product, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this product, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this product do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this product, tell your doctor or pharmacist your medical history, especially of: vitamin B-12 deficiency (pernicious anemia).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Folic acid is safe to take during pregnancy when used as directed. It is included in prenatal vitamin products. Certain spinal cord birth defects may be prevented by taking adequate amounts of folic acid during pregnancy. Consult your doctor for more details.

Folic acid passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Deplin interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: mental/mood changes.

Do not share this medication with others.

Lab and/or medical tests (such as complete blood count, folate blood level, vitamin B-12 blood level) should be done while you are taking this product. Keep all medical and lab appointments. Consult your doctor for more details.

Folate is naturally found in leafy green vegetables, organ meats (liver, kidney), citrus fruits, and other foods. Folic acid is added to enriched grain products such as bread, pasta, and cereal. Consult your doctor or dietician for a diet plan rich in folate/folic acid.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Fitmin Dog Purity Rice Senior, Light Venison, Lamb 2 Kg

Delivery in Chisinau – 40 lei, Free from 350 lei.

Delivery in Chisinau is carried out from Monday to Friday from 10:00 to 22:00, on Saturday from 10:00 to 18:00.

Orders received on weekdays before 14:00 are delivered on the same day, after 14:00 are delivered the next day.

Orders received on Saturday before 12:00 are delivered on the same day, and after 12:00 are delivered on Monday.

Self-delivery of goods is possible by prior agreement at the address: Chisinau, st. Grigore Ureke 14, of. 58

* Express delivery within 2 hours – 95 lei.

Attention!

Orders for delivery within 2 hours are accepted until 14:00!

– Please note that after you place an order, we need some time to process, check and deliver the feed; these operations, as a rule, take no more than 24 hours from the moment of receipt of the application.

– Our operator will contact you and discuss a convenient delivery time for you.

– The courier will call you 30 minutes before the delivery of the goods.

– Delivery is carried out only for the goods registered in the application. Transportation of several goods, in order to select one of them on the spot, is not performed.

You are kindly requested! Check the compliance of the order, the deadlines for implementation, the integrity of the packaging in the presence of the courier!

*** The buyer has the right to return the order to the courier if a marriage or incorrect packaging is found only if the order was checked in the presence of the courier (i. e. upon receipt on the spot).

When choosing dry food by weight, pay attention to the needs of your animal. DRY FOOD SOLD BY WEIGHT IS NOT AVAILABLE FOR EXCHANGE AND REFUND!

– We deliver directly to the door of your home or office. Lift access is free of charge.

– Free of charge without an elevator up to and including the 3rd floor,

if lifting is required from 20 kg above the 3rd floor (without an elevator), each lift is paid – 10 lei for each floor after the third (or you can lift it yourself).
If the courier needs to go up to the floor several times, in case when the entire order of the client did not fit into the hands of the courier at one time, it will be necessary to pay 10 lei for each climb for each floor above 3!

– If there is paid parking or paid entrance to the territory of an office, residential area, enterprise, delivery is carried out only to the place of entry to the paid territory. If it is necessary to enter the protected area, the buyer must ensure the unimpeded entry of the car, take care of the pass in advance.

Payment for goods is made in cash or by bank card to the courier on the spot, as well as payment by Online Mastercard Visa

Delivery to the regions of Moldova within 72 hours – paid for any type of goods. Delivery to the regions is calculated individually. Check with operators.

Delivery Cost Is 40 lei from the order amount over 350 lei and 60 lei from the order amount below 350 lei to the following regions:

* Airport

* Bubuieci

* Bull

* Vatra

* Gratiesti

* Gidigich

* Keltuitor

* Colonica

* Placed

* Togatino, Poiana Nucului

Order Cost Is 50 lei from any order amount:

* Bach oh

* Cricova

to Frumushika, Straisteny – 70 lei

Delivery to Balcata, Budesti, Braila, Dencheni, Trusheni – 80 lei

Delivery to Cojusna, Sirets – 90 lei

Delivery to Bardar, Singera, Suruceni – 100 lei

Delivery to Dobruja – 120 lei

Delivery to Straseni, Vadul-lui-Voda – 140 lei

Delivery to Condrita – 220 lei

Delivery to Orhei – 220 lei 9000 4

Delivery to customs Varnitsa – 200 lei

PRINCIPALA

Adult age/weight 1.5 – 2.5 kg 2.5 – 5 kg 5-10 kg 10-15 kg 15-20 kg 20-30 kg 30-40 kg 40-50 kg 50-60 kg 60 – 70 kg 70 – 80 kg
adult dog – elderly 35 – 45 g 40 – 80 g 70 – 150 g 140 – 200 g 190 – 260 g 240 – 360 g 340-460 g 440 – 540 g 510-620 g 590-700 g 670-780 g
adult dog – fat 30-40 g 35 – 75 g 65 – 135 g 125 – 190 g 180 – 240 g 230 – 320 g 300-410 g 400 – 490 g 460 – 560 g 530-630 g 600-700 g