What is Deplin and how does it work. How is Deplin different from over-the-counter folic acid. What are the potential side effects and interactions of Deplin. How should Deplin be dosed for optimal benefits. Who can benefit most from taking Deplin as a supplement.

Understanding Deplin: A Medical-Grade Form of L-Methylfolate

Deplin is a prescription medical food containing L-methylfolate, the active form of folate (vitamin B9). Unlike over-the-counter folic acid supplements, Deplin provides already-activated folate that the body can immediately utilize. This makes it particularly beneficial for individuals who have difficulty converting folic acid into its active form.

How does Deplin work in the body? L-methylfolate plays a crucial role in the production of neurotransmitters like serotonin, norepinephrine, and dopamine. By enhancing the availability of these mood-regulating chemicals, Deplin may help improve the efficacy of antidepressant medications and support overall mental health.

Indications for Deplin: Who Can Benefit from This Supplement?

Deplin is primarily indicated as an adjunctive therapy for individuals with depression, particularly those who have not responded adequately to traditional antidepressant treatments. However, its potential benefits extend to several other conditions:

• Major depressive disorder (MDD)
• Treatment-resistant depression
• Bipolar depression
• Schizophrenia (as an adjunct to antipsychotic medications)
• Cognitive impairment associated with aging
• Certain metabolic disorders affecting folate metabolism

Is Deplin suitable for everyone with depression? While many individuals may benefit from L-methylfolate supplementation, it’s especially valuable for those with genetic variations affecting folate metabolism, such as mutations in the MTHFR gene. Healthcare providers may recommend genetic testing to determine if a patient is likely to benefit from Deplin.

Deplin Dosing: Finding the Right Amount for Optimal Results

The appropriate Deplin dosage can vary depending on the individual’s specific needs and medical condition. Typically, Deplin is available in two strengths:

• 7.5 mg capsules
• 15 mg capsules

How should Deplin be taken? Most commonly, Deplin is prescribed as a once-daily supplement. The standard starting dose is often 7.5 mg per day, which can be increased to 15 mg if needed. Some healthcare providers may recommend higher doses in certain situations, but this should only be done under close medical supervision.

Can Deplin be taken with or without food? Deplin can be taken with or without food, making it a convenient addition to one’s daily routine. However, consistency is key – it’s best to take Deplin at the same time each day to maintain steady levels in the body.

Factors Influencing Deplin Dosage

Several factors may influence the optimal Deplin dosage for an individual:

1. Severity of symptoms
2. Body weight
3. Genetic factors affecting folate metabolism
4. Concurrent medications
5. Overall health status

Is it possible to take too much Deplin? While L-methylfolate is generally considered safe, excessive doses may lead to adverse effects. It’s crucial to follow the prescribed dosage and consult with a healthcare provider before making any changes.

The Deplin Advantage: How It Differs from Over-the-Counter Folic Acid

One of the key benefits of Deplin is its form of folate. Unlike standard folic acid supplements, Deplin contains L-methylfolate, which is immediately bioavailable to the body. This distinction is particularly important for individuals with certain genetic variations or metabolic issues.

Why is L-methylfolate more effective than folic acid for some people? Up to 70% of individuals with depression may have difficulty converting folic acid into its active form due to genetic variations or other factors. By providing the already-activated form of folate, Deplin bypasses this potential roadblock, ensuring that the body can utilize the nutrient effectively.

Comparing Deplin to Other Folate Supplements

Potential Side Effects and Safety Considerations of Deplin

While Deplin is generally well-tolerated, it’s important to be aware of potential side effects and safety considerations. In clinical trials, the side effects of Deplin were comparable to those of a placebo, indicating a favorable safety profile.

What are the most common side effects of Deplin? Some individuals may experience mild side effects such as:

• Nausea
• Stomach discomfort
• Headache
• Difficulty sleeping
• Irritability

Is Deplin safe to take with antidepressants? Yes, Deplin is considered safe to take alongside most antidepressant medications when used as directed. In fact, it may enhance the effectiveness of these medications in some individuals. However, it’s crucial to inform your healthcare provider about all medications and supplements you’re taking to avoid potential interactions.

Special Populations and Precautions

While Deplin is generally safe, certain populations may require special consideration:

• Pregnant women: Adequate folate intake is crucial during pregnancy, but high doses should be monitored by a healthcare provider.
• Individuals with a history of bipolar disorder: L-methylfolate may potentially trigger manic episodes in some cases.
• Those with allergies: Individuals with allergies to any components of Deplin should avoid its use.

Can Deplin interact with other medications or supplements? While interactions are generally minimal, Deplin may interact with certain medications such as methotrexate or drugs that affect folate metabolism. Always consult with a healthcare provider or pharmacist about potential interactions.

Maximizing the Benefits of Deplin: Tips for Optimal Use

To get the most out of Deplin supplementation, consider the following tips:

1. Consistency is key: Take Deplin at the same time each day to maintain steady levels in your body.
2. Be patient: It may take several weeks to notice the full benefits of Deplin.
3. Combine with a healthy lifestyle: A balanced diet, regular exercise, and stress management can enhance the effects of Deplin.
4. Monitor your response: Keep track of any changes in your mood or symptoms and report them to your healthcare provider.
5. Don’t skip doses: If you miss a dose, take it as soon as you remember, unless it’s close to the time for your next dose.

How long should one take Deplin? The duration of Deplin supplementation can vary depending on individual needs and response. Some individuals may benefit from long-term use, while others may only need it for a specific period. Regular follow-ups with a healthcare provider can help determine the optimal duration of treatment.

The Role of Deplin in Mental Health Treatment

Deplin’s potential to enhance the effectiveness of antidepressant medications has made it an intriguing option in mental health treatment. By addressing potential folate deficiencies or metabolism issues, Deplin may help create a more favorable environment for antidepressant therapy to work.

How does Deplin complement traditional depression treatments? L-methylfolate supports the production of neurotransmitters that are often targeted by antidepressant medications. This synergistic effect may lead to improved outcomes, particularly in individuals who have not responded adequately to antidepressants alone.

Deplin in Treatment-Resistant Depression

For individuals with treatment-resistant depression, Deplin may offer a new avenue for symptom relief. Some studies have shown promising results when L-methylfolate is added to existing antidepressant regimens in patients who have not achieved satisfactory improvement with standard treatments alone.

Can Deplin be used as a standalone treatment for depression? While Deplin can provide important nutritional support, it is not typically used as a standalone treatment for depression. It’s most often prescribed as an adjunct to other therapies, including medications and psychotherapy.

Understanding the Broader Impact of Folate on Health

While Deplin is primarily prescribed for its potential mental health benefits, it’s important to understand the broader role of folate in overall health. Adequate folate levels are crucial for numerous bodily functions, including:

• DNA synthesis and repair
• Red blood cell formation
• Nervous system function
• Cardiovascular health
• Fetal development during pregnancy

How does folate deficiency impact overall health? Folate deficiency can lead to various health issues, including anemia, cognitive impairment, and an increased risk of certain birth defects. By ensuring adequate folate levels through supplements like Deplin, individuals may support not only their mental health but also their overall well-being.

The Folate-Homocysteine Connection

One of the key roles of folate in the body is its involvement in the metabolism of homocysteine, an amino acid that, when elevated, is associated with increased cardiovascular risk. L-methylfolate helps convert homocysteine back to methionine, potentially reducing the risk of cardiovascular issues.

Can Deplin help lower homocysteine levels? While Deplin is not specifically prescribed for this purpose, its active form of folate may help support healthy homocysteine metabolism. Individuals with concerns about cardiovascular health should discuss comprehensive strategies with their healthcare provider.

Accessing and Affording Deplin: Practical Considerations

As a prescription medical food, Deplin may not be covered by all insurance plans. However, there are options available to help make this supplement more accessible and affordable:

1. Prescription savings programs: Some pharmaceutical companies offer savings programs or coupons for Deplin.
2. Brand Direct Health pharmacy: This service offers savings, support, and resources for patients prescribed Deplin.
3. Generic alternatives: While not identical, some generic L-methylfolate supplements may be more affordable options.
4. Discussion with healthcare providers: Sometimes, alternative dosing strategies or comparable supplements may be recommended to manage costs.

How can patients save on Deplin prescriptions? Patients can explore savings options through Brand Direct Health pharmacy by calling 1-866-331-6440 or visiting their website. It’s also worth discussing cost concerns with healthcare providers, as they may be aware of additional resources or alternatives.

Ensuring Continuity of Care

Given the potential benefits of Deplin in managing depression and other conditions, it’s crucial to maintain a consistent supply. Patients should work closely with their healthcare providers and pharmacies to ensure timely refills and address any issues that may arise with prescription coverage or availability.

What should patients do if they can’t afford their Deplin prescription? If cost becomes a barrier, it’s important to communicate this to the prescribing healthcare provider. They may be able to suggest alternatives, adjust dosing, or provide information on patient assistance programs.

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Product Information

How can DEPLIN

^® help me?

DEPLIN^® can provide the body with already-active folate that is ready to help promote the production of natural chemicals in the brain that affect mood and help you get the most out of your antidepressant therapy.

Is DEPLIN

^® safe? What are the side effects?

Yes, DEPLIN^® is generally safe and does not have the side effects of traditional antidepressants. In clinical trials, the side effects of DEPLIN^® were about the same as those of a placebo (a pill or liquid with no active medicine, such as a sugar pill). DEPLIN^®, which is safe to take with antidepressant medications when taken as indicated, is not associated with weight gain, insomnia, or sexual dysfunction.

How is DEPLIN

^® different from over-the-counter (OTC) options?

OTC folic acid needs to be activated by your body before it can be used. Unfortunately, up to 70% of people with depression may have a compromised ability to complete this activation. DEPLIN^® capsules can provide you with already-active folate so your body does not have to activate it for you to see a benefit. DEPLIN^® addresses the body’s nutritional requirements and creates an environment that allows you to get the most out of your antidepressant therapy.

Is there a program to help me save on my prescription?

Yes, you can save on DEPLIN^® with Brand Direct Health^® pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health^® pharmacy, call 1-866-331-6440 or visit www.branddirecthealth.com to learn more.

Symptoms of depression can include:

• Sadness
• Loss of interest or pleasure in activities you used to enjoy
• Change in weight/appetite
• Difficulty sleeping or oversleeping
• Low concentration/Trouble making decisions
• Energy loss/Feeling slowed down
• Feelings of worthlessness
• Thoughts of death or suicide

Adapted from the MedlinePlus website.

Deplin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Folic acid is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.Folic acid supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of folic acid either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Deplin

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Folic acid usually has very few side effects. If you have any unusual effects from taking this product, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this product, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this product do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this product, tell your doctor or pharmacist your medical history, especially of: vitamin B-12 deficiency (pernicious anemia).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Folic acid is safe to take during pregnancy when used as directed. It is included in prenatal vitamin products. Certain spinal cord birth defects may be prevented by taking adequate amounts of folic acid during pregnancy. Consult your doctor for more details.

Folic acid passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Deplin interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: mental/mood changes.

Do not share this medication with others.

Lab and/or medical tests (such as complete blood count, folate blood level, vitamin B-12 blood level) should be done while you are taking this product. Keep all medical and lab appointments. Consult your doctor for more details.

Folate is naturally found in leafy green vegetables, organ meats (liver, kidney), citrus fruits, and other foods. Folic acid is added to enriched grain products such as bread, pasta, and cereal. Consult your doctor or dietician for a diet plan rich in folate/folic acid.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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instructions for use, dosages, composition, analogues, side effects / Pillintrip

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Page reviewed by pharmacist Fedorchenko Olga Valerievna Last update 2022-03-12

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The information on this page is for healthcare professionals only!
The information is collected from open sources and may contain significant errors!
Be careful and double-check all the information on this page!

Top 20 drugs with the same ingredients:

Gyno-TardyferonFolbiolFerronemiaFolicilFysiofolBialferFolavitMaltofer FolMaterfolFeofolFolicronTardyferon FolFefolFolimenUniferolFolic AcidFolviteGyno TardyferonFolasHuma-Folaci d

Top 20 drugs with the same use:

Maxifol 5000FolsanHBHHAcide Folique ArrowFegemFol LichtensteinFolacFolivitalPediafolicFolsäure-ratiopharmAcfolAcide Folique CCDAndreafolFilicineAcido Folico A. M.AcifolFolaci dFolic Acid-Tsiteli AFolimaxFolin

Name of the drug

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Deplin

Composition

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Folic Acid

Therapeutic Indications

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folate deficiency anemia;

Hypo- and avitaminosis of folic acid (including with tropical sprue, celiac disease, malnutrition).

treatment and prevention of folic acid deficiency due to unbalanced or malnutrition;

treatment and prevention of anemia due to folic acid deficiency: macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, postresection anemia, sideroblastic anemia in the elderly, anemia associated with diseases of the small intestine, sprue and malabsorption syndrome ;

treatment and prevention of anemia during pregnancy and lactation;

during pregnancy – prevention of the development of neural tube defects in the fetus;

long-term treatment with folic acid antagonists (methotrexate, a combination of sulfamethoxazole and trimethoprim), anticonvulsants (phenytoin, primidone, phenobarbital).

Dosage and Administration

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Int.

Folate deficiency anemia: adults and children of any age starting dose – 1 mg / day. At high doses, resistance may occur.

Maintenance treatment: neonatal 0.1 mg/day; for children under 4 years old – 0.3 mg / day; for children over 4 years old and adults – 0.4 mg / day; during pregnancy and lactation – from 0.1 to 0. 8 mg / day.

With hypo- and avitaminosis of folic acid (depending on the severity of avitaminosis): adults – up to 5 mg / day; children – in smaller doses depending on age. The course of treatment is 20-30 days.

With concomitant alcoholism, hemolytic anemia, chronic infectious diseases, after gastrectomy, malabsorption syndrome, liver failure, liver cirrhosis, stress, the dose of the drug should be increased to 5 mg / day.

Treatment of megaloblastic anemia due to folic acid deficiency – 5 mg / day for 4 months, prevention – 2.5 mg / day.

Prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel disease and unbalanced or malnutrition – 15 mg / day, in patients with sprue – 5-15 mg / day.

Prevention of the development of neural tube defects in the fetus – 2.5 mg / day for 4 weeks before the expected pregnancy, continue taking it during the first trimester of pregnancy.

Higher maintenance doses may be given to patients suffering from alcoholism, as well as to patients with chronic infections and taking anticonvulsants.

Contraindications

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hypersensitivity to drug components;

B ₁₂ – deficiency anemia;

sucrase deficiency;

isomaltase deficiency;

fructose intolerance;

glucose-galactose malabsorption;

children’s age (up to 3 years).

Precautions: folate deficiency anemia with cyanocobalamin deficiency.

hypersensitivity to drug components;

pernicious anemia;

malignant neoplasms;

cobalamin deficiency.

Adverse effects

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Allergic reactions – skin rash, pruritus, bronchospasm, erythema, hyperthermia.

Allergic reactions: possible development of skin rashes, itching, erythema, bronchospasm.

From the gastrointestinal tract: anorexia, nausea, bloating, bitterness in the mouth.

Overdose

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Doses of folic acid up to 4–5 mg are well tolerated. Higher doses may cause CNS and GI disturbances.

No cases of overdose have been reported.

Pharmacodynamics

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Vitamin B group (vitamin B _c , vitamin B ₉ ), can be synthesized and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine.

Vitamin B. In the body it is converted into tetrahydrofolic acid, which is involved in various metabolic processes as a coenzyme and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. With a deficiency of folic acid, a megaloblastic type of hematopoiesis develops. Stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine. During pregnancy, it performs a protective function in relation to the action of teratogenic and fetal-damaging factors. Contributes to the normal maturation and functioning of the placenta.

Pharmacokinetics

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Folic acid is well and completely absorbed in the gastrointestinal tract, mainly in the upper duodenum (even in the presence of malabsorption syndrome against the background of tropical sprue).

Intensively binds to plasma proteins. Penetrates through the BBB, the placenta, and also into breast milk. T _max – 30-60 min. It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase).

Excreted by the kidneys mainly as metabolites. If the accepted dose significantly exceeds the daily requirement for folic acid, then it is excreted unchanged.

Eliminated by hemodialysis.

After oral administration, folic acid, combining in the stomach with the internal factor of Castle (a specific glycoprotein), is well and completely absorbed in the gastrointestinal tract. Almost completely bound to plasma proteins.

Deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of the enzyme dihydrofolate reductase). Penetrates through the BBB, the placenta and into breast milk. C _max in the blood is achieved in 30–60 minutes. It is excreted by the kidneys both unchanged (if the accepted dose significantly exceeds the daily requirement), and in the form of metabolites. Excreted by hemodialysis. 5 mg of folic acid taken orally is excreted from the body after 5 hours.0072 . Be
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Anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.

Antacids (including calcium, aluminum and magnesium preparations), cholestyramine, sulfonamides (including sulfasalazine) reduce the absorption of folic acid.

Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (calcium folinate should be given instead in patients using these drugs).

There is no definitive information regarding zinc preparations: some studies show that folate inhibits zinc absorption, others do not.

When used simultaneously with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid is reduced.

With simultaneous use, folic acid reduces the effects of oral contraceptives, ethanol, sulfasalazine, cycloserine and glutethimide, methotrexate, phenytoin, primidone, chloramphenicol.

Folic acid may decrease plasma levels of phenobarbital, phenytoin, or primidone and cause an epileptic seizure.

Decreased or altered absorption may occur with co-administration of cholestyramine and folic acid, so folic acid should be taken 1 hour before or 4 to 6 hours after cholestyramine.

Pharmacological group

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• Hemopoiesis stimulants
• Vitamins and vitamin-like preparations

• Vitamin; hematopoiesis stimulator [Hematopoiesis stimulants]
• Vitamin; hematopoiesis stimulant [Vitamins and vitamin-like products]

Deplin price

We don’t have exact price data for this medicine.
However, we will provide data for each active ingredient

The average cost of Folic Acid 5 mg per unit in online pharmacies is from $0.25 to $0.84, per package from $25 to $92.

The average cost of Folic Acid 1 mg per unit in online pharmacies is from $0.21 to $0.21, per package from $21 to $21.

Sources:

• https://www.drugs.com/mtm/deplin.html
• https://pubmed.ncbi.nlm.nih.gov/?term=deplin

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Deplin (L-Methylfolate [from Metafolin] and Algae-S Powder [Schizochytrium] Therapeutic Nutrition Prescription): Uses, Dosage, Side Effects, Interactions, Warning

Full

• Generic Name: l-methylfolate [from metafolin] and seaweed powder [schizophrenia] Prescription Health Nutrition
• Brand Name: Complete

• Product description
• Indications and dosage
• Side effects and drug interactions
• Warnings and precautions
• Overdose and contraindications
• Clinical pharmacology
• Medication Guide

Product Description

FULL 7. 5 capsules

FULL 15 capsules

DESCRIPTION

DEPLIN is a prescription medical food for use only under the supervision of a physician for the clinical dietary treatment of depression and schizophrenia and is specifically formulated to meet the specific nutritional requirements of these conditions.

Each DEPLIN 7.5 capsule contains 7.5 mg of L-methylfolate (from Metafolin) and 90.314 mg of Algae-S powder (Schizochytrium). CAS No. 151533-22-1

Each DEPLIN 15 capsule contains 15.0 mg of L-methylfolate (from Metafolin) and 90.314 mg Algae-S powder (Schizochytrium). CAS No. 151533-22-1

how much milk thistle per day

Ingredients

COMPLETE 7.5

Silicified Microcrystalline Cellulose, Algae-S Powder (Schizochytrium Algae Oil [vegetable source], Glucose Syrup Solids, Mannitol, Sodium Caseinate (Milk), Soy Protein, High Oleic Sunflower Oil, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate, natural flavors, soy lecithin, and a mixture of natural tocopherols and ascorbyl palmitate [as antioxidants]), Pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source), FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, FD&C Yellow #6 Aluminum Lake, Shellac. Contains milk and soy

FULL 15

Siliconized microcrystalline cellulose, Algae-S powder (Schizochytrium algae oil [vegetable source], glucose syrup solids, mannitol, sodium caseinate (milk), soy protein, high sunflower oil oleic acid, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate Natural flavors, soy lecithin and mixed natural tocopherols and ascorbyl palmitate [as antioxidants]), pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source) )], FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, shellac. Contains milk and soy

DEPLIN is a medical prescription food for use only under medical supervision.

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Medical foods are intended for patients who have a limited or impaired ability to take in, digest, absorb, or metabolize common foods or certain nutrients, or who have other special medical nutritional requirements for which dietary regulation cannot be achieved by modifications. just a normal diet. ¹ This product is not an Orange Book product.

RECOMMENDATIONS

1. US Food and Drug Administration 21 CFR 101.9(j)(8).

Adverse effects and drug interactions

SIDE EFFECTS

Allergic reactions have been reported following oral administration of L-methylfolate. ¹¹

DRUG INTERACTIONS

Information not provided

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RECOMMENDATIONS

11. Natural Standards Collaboration (NIH). Folate (Folic Acid) 2009 Monograph.

PRECAUTIONS

General

L-methylfolate (DEPLIN) is not interchangeable with folic acid. In some patients, folic acid is not effective in influencing folic acid levels in the brain due to the low rate of transport of folic acid across the blood-brain barrier and/or low levels in the brain of an enzyme needed to convert folic acid into a biological and functional form. ^7-9

Patients at risk of vitamin B12 deficiency should consult their physician before taking L-methylfolate.