Deplin vitamin. DEPLIN: The Missing Piece in Depression Treatment – L-Methylfolate Supplement
What is DEPLIN and how does it work. How is DEPLIN different from over-the-counter folic acid. Can DEPLIN help improve antidepressant effectiveness. Is DEPLIN safe to take with other depression medications. How can patients save money on DEPLIN prescriptions.
Understanding DEPLIN: A Prescription Folate Supplement for Depression
DEPLIN is a prescription medical food containing L-methylfolate, the active form of folate (vitamin B9). It is specifically formulated to meet the nutritional needs of people with depression and can be used alongside antidepressant medications. But what exactly makes DEPLIN unique in the treatment of depression?
Key Features of DEPLIN:
- Contains 15 mg of Metafolin, a branded active folate
- Most prescribed product in its class
- Clinically studied in over 25 trials
- Can be used with current antidepressant therapy
- Helps the brain naturally improve mood
DEPLIN addresses a critical aspect of depression treatment that is often overlooked – the role of folate in brain chemistry. For many individuals with depression, their bodies may require additional active folate to support optimal mental health.
The Science Behind DEPLIN: How L-Methylfolate Supports Mental Health
To understand why DEPLIN can be beneficial, it’s important to explore the connection between folate and depression. How does this B-vitamin impact our mood and mental well-being?
Folate’s Role in Brain Chemistry:
- Essential for neurotransmitter production
- Supports methylation processes in the brain
- Helps regulate mood and cognitive function
- Low levels linked to increased depression risk
In individuals with depression, there may be a higher demand for active folate. Without sufficient levels, the effectiveness of antidepressant medications can be compromised. DEPLIN provides a direct source of L-methylfolate, bypassing potential genetic or metabolic issues that may impair folate activation.
DEPLIN vs. Over-the-Counter Folic Acid: Understanding the Difference
Many people wonder why they can’t simply take an over-the-counter folic acid supplement instead of prescription DEPLIN. The answer lies in the form of folate provided and how the body processes it.
Key Differences:
- DEPLIN contains L-methylfolate, the active form of folate
- OTC folic acid requires activation by the body
- Up to 70% of people with depression may have difficulty activating folic acid
- DEPLIN bypasses the need for activation, providing readily usable folate
This distinction is crucial, especially for individuals with genetic variations or other factors that may impair their ability to convert folic acid into its active form. DEPLIN ensures that the body receives the folate it needs in a form it can immediately use.
Enhancing Antidepressant Efficacy: How DEPLIN Supports Treatment
One of the primary benefits of DEPLIN is its potential to improve the effectiveness of antidepressant medications. But how exactly does it accomplish this?
Mechanisms of Action:
- Supports neurotransmitter production
- Enhances methylation processes in the brain
- May help overcome genetic factors affecting antidepressant response
- Provides nutritional support for optimal brain function
By addressing potential folate deficiencies or metabolic issues, DEPLIN creates an environment in the brain that may allow antidepressants to work more effectively. This can be particularly beneficial for individuals who have experienced partial or inadequate responses to their current medication regimen.
Safety Profile and Tolerability of DEPLIN
When considering any new supplement or medication, safety is a primary concern. How does DEPLIN fare in terms of side effects and interactions with other medications?
Safety Considerations:
- Generally well-tolerated
- Side effect profile similar to placebo in clinical trials
- No association with common antidepressant side effects (weight gain, insomnia, sexual dysfunction)
- Safe to take with antidepressant medications when used as directed
The favorable safety profile of DEPLIN makes it an attractive option for individuals seeking to enhance their depression treatment without adding significant risk of adverse effects. However, as with any medical intervention, it should only be used under the supervision of a healthcare provider.
Identifying Candidates for DEPLIN: Is It Right for You?
While DEPLIN can be beneficial for many individuals with depression, it may be particularly suitable for certain groups. How can you determine if DEPLIN might be appropriate for your situation?
Potential Indicators for DEPLIN Use:
- Incomplete response to current antidepressant therapy
- History of switching between multiple antidepressants
- Currently taking more than one antidepressant
- Known genetic variations affecting folate metabolism
- Desire to optimize nutritional support for mental health
If you identify with any of these scenarios, it may be worth discussing DEPLIN with your healthcare provider. They can help assess your individual needs and determine if DEPLIN could be a valuable addition to your treatment plan.
Accessing DEPLIN: Prescription Process and Cost Considerations
For those interested in trying DEPLIN, understanding how to obtain it and manage potential costs is important. What steps are involved in getting a DEPLIN prescription, and are there ways to make it more affordable?
Obtaining and Affording DEPLIN:
- Consult with a healthcare provider to discuss DEPLIN
- Obtain a prescription if deemed appropriate
- Explore cost-saving options through Brand Direct Health pharmacy
- Consider patient assistance programs or insurance coverage
While DEPLIN is a prescription product, there are resources available to help make it more accessible. The Brand Direct Health pharmacy offers savings, support, and resources for patients prescribed DEPLIN.
The Broader Context: DEPLIN and Comprehensive Depression Management
It’s important to view DEPLIN as part of a holistic approach to depression treatment. How does DEPLIN fit into the larger picture of mental health management?
Integrating DEPLIN into Depression Care:
- Complement to antidepressant medications
- Supports overall nutritional health
- May enhance effectiveness of psychotherapy
- Part of a multi-faceted treatment approach
While DEPLIN can be a valuable tool in managing depression, it’s most effective when used as part of a comprehensive treatment plan. This may include medication, therapy, lifestyle changes, and other interventions tailored to individual needs.
Future Directions: Research and Potential Applications of L-Methylfolate
As our understanding of depression and its biological underpinnings continues to evolve, so too does the potential role of L-methylfolate supplements like DEPLIN. What areas of research are currently being explored?
Emerging Research Areas:
- Personalized medicine approaches based on genetic profiles
- Potential applications in other mental health conditions
- Long-term effects of L-methylfolate supplementation
- Combination therapies with novel antidepressants
Ongoing research may uncover new applications and refine our understanding of how L-methylfolate can be best utilized in mental health treatment. This continued exploration holds promise for improving outcomes for individuals with depression and related disorders.
Navigating Depression Treatment: When to Consider DEPLIN
Depression is a complex condition that often requires a multifaceted approach to treatment. At what point in the treatment journey might DEPLIN be considered as an option?
Scenarios Where DEPLIN May Be Beneficial:
- Persistent symptoms despite antidepressant use
- Recurrent episodes of depression
- Difficulty tolerating higher doses of antidepressants
- Known folate deficiency or metabolic issues
- Interest in nutritional approaches to mental health
It’s important to have open discussions with your healthcare provider about your depression symptoms and treatment goals. They can help determine if and when adding DEPLIN to your regimen might be appropriate.
The Patient Experience: Real-World Perspectives on DEPLIN
While clinical data is crucial, understanding the experiences of individuals who have used DEPLIN can provide valuable insights. What do patients typically report about their experiences with DEPLIN?
Common Patient Observations:
- Gradual improvement in mood and energy levels
- Enhanced effectiveness of existing antidepressants
- Minimal side effects compared to other interventions
- Appreciation for a nutritional approach to treatment
- Varying timelines for noticing benefits
It’s important to note that individual experiences with DEPLIN can vary. Some people may notice improvements relatively quickly, while others may require more time to see effects. Consistent use and ongoing communication with healthcare providers are key to optimizing outcomes.
Addressing Common Concerns: DEPLIN FAQ
As with any medical intervention, patients often have questions and concerns about DEPLIN. What are some of the most frequently asked questions regarding this supplement?
Common Questions About DEPLIN:
- How long does it take to see results?
- Can DEPLIN replace my current antidepressant?
- Are there any dietary restrictions while taking DEPLIN?
- How is DEPLIN different from other B-vitamin supplements?
- Can DEPLIN be used during pregnancy or breastfeeding?
These questions highlight the importance of patient education and open communication with healthcare providers. Understanding the role of DEPLIN, its potential benefits, and any considerations for use can help patients make informed decisions about their treatment.
DEPLIN and the Future of Depression Treatment
As our understanding of depression continues to evolve, so too do the approaches to treating this complex condition. How might DEPLIN and similar nutritional interventions shape the future landscape of mental health care?
Potential Future Developments:
- Integration of genetic testing to guide folate supplementation
- Expanded research into other forms of bioavailable nutrients
- Development of combination products targeting multiple nutritional factors
- Increased focus on personalized, nutrition-based mental health strategies
The use of L-methylfolate in depression treatment represents a growing recognition of the role nutrition plays in mental health. As research progresses, we may see an even greater emphasis on addressing the biological underpinnings of depression through targeted nutritional interventions like DEPLIN.
Making Informed Decisions: Discussing DEPLIN with Your Healthcare Provider
For individuals considering DEPLIN as part of their depression treatment plan, having a productive conversation with a healthcare provider is crucial. How can patients approach this discussion effectively?
Tips for Discussing DEPLIN with Your Doctor:
- Prepare a list of current medications and supplements
- Document your depression symptoms and treatment history
- Research basic information about DEPLIN beforehand
- Be open about your treatment goals and concerns
- Ask about potential benefits, risks, and alternatives
Remember that your healthcare provider is your partner in managing your mental health. They can provide personalized guidance on whether DEPLIN may be appropriate for your specific situation and how it might fit into your overall treatment plan.
Conclusion: DEPLIN as a Complementary Approach to Depression Management
DEPLIN represents an innovative approach to addressing the nutritional aspects of depression treatment. By providing L-methylfolate, the active form of folate, it offers a way to support brain chemistry and potentially enhance the effectiveness of antidepressant medications.
While not a standalone cure for depression, DEPLIN can be a valuable tool in a comprehensive treatment strategy. Its unique formulation, favorable safety profile, and potential to address underlying metabolic factors make it an option worth considering for many individuals struggling with depression.
As with any medical decision, the choice to use DEPLIN should be made in consultation with a qualified healthcare provider. By understanding its role, benefits, and considerations, patients can make informed choices about incorporating DEPLIN into their depression management plan.
Ultimately, the goal is to find the most effective combination of treatments to alleviate depression symptoms and improve quality of life. For some, DEPLIN may prove to be an important piece of that puzzle, offering support for mental health through targeted nutritional intervention.
What Is DEPLIN®? | DEPLIN®
DEPLIN®, a prescription product, is specially formulated to meet the nutritional needs of people with depression and can be used with your current antidepressant. DEPLIN® capsules contain L-methylfolate, an active form of folate. Folate, which is one of the body’s essential B vitamins, helps the brain naturally improve your mood.
If you have depression, your body may need more active folate. Low levels of active folate can make it harder to see results from your antidepressant. Not having enough active folate may also put you at risk of your depression coming back, even after it has gone away.
DEPLIN® is prescribed by healthcare professionals and should only be used under the supervision of a physician. Please see your healthcare provider to determine if DEPLIN® is right for you.
DEPLIN
® is the most prescribed product in its class
DEPLIN® is the only product with 15 mg of Metafolin®*, which is branded active folate. Metafolin® is clinically proven and has been widely studied in over 25 clinical trials as registered on ClinicalTrials.gov.
*Metafolin is a registered trademark of Merck KGaA, Darmstadt, Germany.
Discover the DEPLIN® Difference
See how
DEPLIN® is different from over-the-counter folic acid.
What Is DEPLIN®?
The DEPLIN® Difference
Is DEPLIN® Right for You?
Share Your Story
Resources
Save on DEPLIN®
Frequently Asked Questions
For Healthcare Professionals
The Folate Story
Different From OTC Folic Acid
How DEPLIN® Works
An Expert’s Perspective
Safety and Tolerability
Request a Visit
Help Patients Save on DEPLIN®
Product Information
How can DEPLIN
® help me?
DEPLIN® can provide the body with already-active folate that is ready to help promote the production of natural chemicals in the brain that affect mood and help you get the most out of your antidepressant therapy.
Is DEPLIN
® safe? What are the side effects?
Yes, DEPLIN® is generally safe and does not have the side effects of traditional antidepressants. In clinical trials, the side effects of DEPLIN® were about the same as those of a placebo (a pill or liquid with no active medicine, such as a sugar pill). DEPLIN®, which is safe to take with antidepressant medications when taken as indicated, is not associated with weight gain, insomnia, or sexual dysfunction.
How is DEPLIN
® different from over-the-counter (OTC) options?
OTC folic acid needs to be activated by your body before it can be used. Unfortunately, up to 70% of people with depression may have a compromised ability to complete this activation. DEPLIN® capsules can provide you with already-active folate so your body does not have to activate it for you to see a benefit. DEPLIN® addresses the body’s nutritional requirements and creates an environment that allows you to get the most out of your antidepressant therapy.
Is there a program to help me save on my prescription?
Yes, you can save on DEPLIN® with Brand Direct Health® pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health® pharmacy, call 1-866-331-6440 or visit www.branddirecthealth.com to learn more.
Symptoms of depression can include:
- Sadness
- Loss of interest or pleasure in activities you used to enjoy
- Change in weight/appetite
- Difficulty sleeping or oversleeping
- Low concentration/Trouble making decisions
- Energy loss/Feeling slowed down
- Feelings of worthlessness
- Thoughts of death or suicide
Adapted from the MedlinePlus website.
Add the Missing Peace | DEPLIN®
DEPLIN
® can make a difference when used with an antidepressant
DEPLIN® is specially formulated to meet the nutritional needs of people with depression and can be used with your current antidepressant. Adding DEPLIN®, a prescription product that contains L-methylfolate, can help your antidepressant work better, without the side effects of traditional depression medications.
Learn more about DEPLIN®.
What Is DEPLIN®?
Depression is a medical illness that affects the brain
Depression is more than just a feeling of being “down in the dumps” for a few days. If you are one of the almost 20 million people in the United States who have depression, the feelings do not just disappear. They continue and get in the way of your everyday life.
There are effective treatments for depression, including antidepressants and psychotherapy. Most people usually combine these two. Sometimes, however, treatments for depression can fall short, leaving people to wonder if there is more that can be done.
Do you wish your antidepressant was working better?
Have you switched your antidepressant in the past?
Are you currently taking more than one antidepressant?
If you answered “yes” to any of these questions, bring this discussion guide to your next doctor’s appointment to help you learn more about your depression.
Download the Discussion Guide
What Is DEPLIN®?
The DEPLIN® Difference
Is DEPLIN® Right for You?
Share Your Story
Resources
Save on DEPLIN®
Frequently Asked Questions
For Healthcare Professionals
The Folate Story
Different From OTC Folic Acid
How DEPLIN® Works
An Expert’s Perspective
Safety and Tolerability
Request a Visit
Help Patients Save on DEPLIN®
Product Information
How can DEPLIN
® help me?
DEPLIN® can provide the body with already-active folate that is ready to help promote the production of natural chemicals in the brain that affect mood and help you get the most out of your antidepressant therapy.
Is DEPLIN
® safe? What are the side effects?
Yes, DEPLIN® is generally safe and does not have the side effects of traditional antidepressants. In clinical trials, the side effects of DEPLIN® were about the same as those of a placebo (a pill or liquid with no active medicine, such as a sugar pill). DEPLIN®, which is safe to take with antidepressant medications when taken as indicated, is not associated with weight gain, insomnia, or sexual dysfunction.
How is DEPLIN
® different from over-the-counter (OTC) options?
OTC folic acid needs to be activated by your body before it can be used. Unfortunately, up to 70% of people with depression may have a compromised ability to complete this activation. DEPLIN® capsules can provide you with already-active folate so your body does not have to activate it for you to see a benefit. DEPLIN® addresses the body’s nutritional requirements and creates an environment that allows you to get the most out of your antidepressant therapy.
Is there a program to help me save on my prescription?
Yes, you can save on DEPLIN® with Brand Direct Health® pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health® pharmacy, call 1-866-331-6440 or visit www.branddirecthealth.com to learn more.
Symptoms of depression can include:
- Sadness
- Loss of interest or pleasure in activities you used to enjoy
- Change in weight/appetite
- Difficulty sleeping or oversleeping
- Low concentration/Trouble making decisions
- Energy loss/Feeling slowed down
- Feelings of worthlessness
- Thoughts of death or suicide
Adapted from the MedlinePlus website.
instructions for use, dosages, composition, analogues, side effects / Pillintrip
Name of the drug |
Composition |
Therapeutic indications |
Dosage and administration |
Contraindications |
Side effects |
Overdose |
Pharmacodynamics |
Pharmacokinetics |
Interaction |
Pharmacological group |
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Page reviewed by pharmacist Fedorchenko Olga Valerievna Last update 2022-03-12
Attention!
The information on this page is for healthcare professionals only!
The information is collected from open sources and may contain significant errors!
Be careful and double-check all the information on this page!
Top 20 drugs with the same ingredients:
Gyno-TardyferonFolbiolFerronemiaFolicilFysiofolBialferFolavitMaltofer FolMaterfolFeofolFolicronTardyferon FolFefolFolimenUniferolFolic AcidFolviteGyno TardyferonFolasHuma-Folaci d
Top 20 drugs with the same use:
Maxifol 5000FolsanHBHHAcide Folique ArrowFegemFol LichtensteinFolacFolivitalPediafolicFolsäure-ratiopharmAcfolAcide Folique CCDAndreafolFilicineAcido Folico A. M.AcifolFolaci dFolic Acid-Tsiteli AFolimaxFolin
Name of the drug
The information provided in section Name of the drug Deplin is based on data from another medicine with exactly the same composition as the drug Deplin . Be
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Deplin
Composition
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Folic Acid
Therapeutic Indications
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folate deficiency anemia;
Hypo- and avitaminosis of folic acid (including with tropical sprue, celiac disease, malnutrition).
treatment and prevention of folic acid deficiency due to unbalanced or malnutrition;
treatment and prevention of anemia due to folic acid deficiency: macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, postresection anemia, sideroblastic anemia in the elderly, anemia associated with diseases of the small intestine, sprue and malabsorption syndrome ;
treatment and prevention of anemia during pregnancy and lactation;
during pregnancy – prevention of the development of neural tube defects in the fetus;
long-term treatment with folic acid antagonists (methotrexate, a combination of sulfamethoxazole and trimethoprim), anticonvulsants (phenytoin, primidone, phenobarbital).
Dosage and Administration
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Int.
Folate deficiency anemia: adults and children of any age starting dose – 1 mg / day. At high doses, resistance may occur.
Maintenance treatment: neonatal 0.1 mg/day; for children under 4 years old – 0.3 mg / day; for children over 4 years old and adults – 0.4 mg / day; during pregnancy and lactation – from 0.1 to 0. 8 mg / day.
With hypo- and avitaminosis of folic acid (depending on the severity of avitaminosis): adults – up to 5 mg / day; children – in smaller doses depending on age. The course of treatment is 20-30 days.
With concomitant alcoholism, hemolytic anemia, chronic infectious diseases, after gastrectomy, malabsorption syndrome, liver failure, liver cirrhosis, stress, the dose of the drug should be increased to 5 mg / day.
Treatment of megaloblastic anemia due to folic acid deficiency – 5 mg / day for 4 months, prevention – 2.5 mg / day.
Prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel disease and unbalanced or malnutrition – 15 mg / day, in patients with sprue – 5-15 mg / day.
Prevention of the development of neural tube defects in the fetus – 2.5 mg / day for 4 weeks before the expected pregnancy, continue taking it during the first trimester of pregnancy.
Higher maintenance doses may be given to patients suffering from alcoholism, as well as to patients with chronic infections and taking anticonvulsants.
Contraindications
The information provided in section Contraindications Deplin is based on data from another medicine with exactly the same composition as medicine Deplin . Be
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hypersensitivity to drug components;
B 12 – deficiency anemia;
sucrase deficiency;
isomaltase deficiency;
fructose intolerance;
glucose-galactose malabsorption;
children’s age (up to 3 years).
Precautions: folate deficiency anemia with cyanocobalamin deficiency.
hypersensitivity to drug components;
pernicious anemia;
malignant neoplasms;
cobalamin deficiency.
Adverse effects
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Allergic reactions – skin rash, pruritus, bronchospasm, erythema, hyperthermia.
Allergic reactions: possible development of skin rashes, itching, erythema, bronchospasm.
From the gastrointestinal tract: anorexia, nausea, bloating, bitterness in the mouth.
Overdose
Provided in Section Overdose Deplin information based on data from another medicine with exactly the same composition as Deplin . Be
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in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.
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Doses of folic acid up to 4–5 mg are well tolerated. Higher doses may cause CNS and GI disturbances.
No cases of overdose have been reported.
Pharmacodynamics
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Vitamin B group (vitamin B c , vitamin B 9 ), can be synthesized and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine.
Vitamin B. In the body it is converted into tetrahydrofolic acid, which is involved in various metabolic processes as a coenzyme and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. With a deficiency of folic acid, a megaloblastic type of hematopoiesis develops. Stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine. During pregnancy, it performs a protective function in relation to the action of teratogenic and fetal-damaging factors. Contributes to the normal maturation and functioning of the placenta.
Pharmacokinetics
The information provided in section Pharmacokinetics Deplin is based on data from another medicine with exactly the same composition as the drug Deplin . Be
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Folic acid is well and completely absorbed in the gastrointestinal tract, mainly in the upper duodenum (even in the presence of malabsorption syndrome against the background of tropical sprue).
Intensively binds to plasma proteins. Penetrates through the BBB, the placenta, and also into breast milk. T max – 30-60 min. It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase).
Excreted by the kidneys mainly as metabolites. If the accepted dose significantly exceeds the daily requirement for folic acid, then it is excreted unchanged.
Eliminated by hemodialysis.
After oral administration, folic acid, combining in the stomach with the internal factor of Castle (a specific glycoprotein), is well and completely absorbed in the gastrointestinal tract. Almost completely bound to plasma proteins.
Deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of the enzyme dihydrofolate reductase). Penetrates through the BBB, the placenta and into breast milk. C max in the blood is achieved in 30–60 minutes. It is excreted by the kidneys both unchanged (if the accepted dose significantly exceeds the daily requirement), and in the form of metabolites. Excreted by hemodialysis. 5 mg of folic acid taken orally is excreted from the body after 5 hours.0072 . Be
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Anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.
Antacids (including calcium, aluminum and magnesium preparations), cholestyramine, sulfonamides (including sulfasalazine) reduce the absorption of folic acid.
Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (calcium folinate should be given instead in patients using these drugs).
There is no definitive information regarding zinc preparations: some studies show that folate inhibits zinc absorption, others do not.
When used simultaneously with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid is reduced.
With simultaneous use, folic acid reduces the effects of oral contraceptives, ethanol, sulfasalazine, cycloserine and glutethimide, methotrexate, phenytoin, primidone, chloramphenicol.
Folic acid may decrease plasma levels of phenobarbital, phenytoin, or primidone and cause an epileptic seizure.
Decreased or altered absorption may occur with co-administration of cholestyramine and folic acid, so folic acid should be taken 1 hour before or 4 to 6 hours after cholestyramine.
Pharmacological group
The information provided in section Pharmacological group Deplin is based on data from another medicine with exactly the same composition as drug Deplin . Be
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- Hemopoiesis stimulants
- Vitamins and vitamin-like preparations
- Vitamin; hematopoiesis stimulator [Hematopoiesis stimulants]
- Vitamin; hematopoiesis stimulant [Vitamins and vitamin-like products]
Deplin price
We don’t have exact price data for this medicine.
However, we will provide data for each active ingredient
The average cost of Folic Acid 5 mg per unit in online pharmacies is from $0.25 to $0.84, per package from $25 to $92.
The average cost of Folic Acid 1 mg per unit in online pharmacies is from $0.21 to $0.21, per package from $21 to $21.
Sources:
- https://www.drugs.com/mtm/deplin.html
- https://pubmed.ncbi.nlm.nih.gov/?term=deplin
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Deplin (L-Methylfolate [from Metafolin] and Algae-S Powder [Schizochytrium] Therapeutic Nutrition Prescription): Uses, Dosage, Side Effects, Interactions, Warning
Full
- Generic Name: l-methylfolate [from metafolin] and seaweed powder [schizophrenia] Prescription Health Nutrition
- Brand Name: Complete
- Product description
- Indications and dosage
- Side effects and drug interactions
- Warnings and precautions
- Overdose and contraindications
- Clinical pharmacology
- Medication Guide
Product Description
FULL 7. 5 capsules
FULL 15 capsules
DESCRIPTION
DEPLIN is a prescription medical food for use only under the supervision of a physician for the clinical dietary treatment of depression and schizophrenia and is specifically formulated to meet the specific nutritional requirements of these conditions.
Each DEPLIN 7.5 capsule contains 7.5 mg of L-methylfolate (from Metafolin) and 90.314 mg of Algae-S powder (Schizochytrium). CAS No. 151533-22-1
Each DEPLIN 15 capsule contains 15.0 mg of L-methylfolate (from Metafolin) and 90.314 mg Algae-S powder (Schizochytrium). CAS No. 151533-22-1
how much milk thistle per day
Ingredients
COMPLETE 7.5
Silicified Microcrystalline Cellulose, Algae-S Powder (Schizochytrium Algae Oil [vegetable source], Glucose Syrup Solids, Mannitol, Sodium Caseinate (Milk), Soy Protein, High Oleic Sunflower Oil, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate, natural flavors, soy lecithin, and a mixture of natural tocopherols and ascorbyl palmitate [as antioxidants]), Pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source), FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, FD&C Yellow #6 Aluminum Lake, Shellac. Contains milk and soy
FULL 15
Siliconized microcrystalline cellulose, Algae-S powder (Schizochytrium algae oil [vegetable source], glucose syrup solids, mannitol, sodium caseinate (milk), soy protein, high sunflower oil oleic acid, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate Natural flavors, soy lecithin and mixed natural tocopherols and ascorbyl palmitate [as antioxidants]), pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source) )], FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, shellac. Contains milk and soy
DEPLIN is a medical prescription food for use only under medical supervision.
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Medical foods are intended for patients who have a limited or impaired ability to take in, digest, absorb, or metabolize common foods or certain nutrients, or who have other special medical nutritional requirements for which dietary regulation cannot be achieved by modifications. just a normal diet. 1 This product is not an Orange Book product.
RECOMMENDATIONS
1. US Food and Drug Administration 21 CFR 101.9(j)(8).
Adverse effects and drug interactions
SIDE EFFECTS
Allergic reactions have been reported following oral administration of L-methylfolate. 11
DRUG INTERACTIONS
Information not provided
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RECOMMENDATIONS
11. Natural Standards Collaboration (NIH). Folate (Folic Acid) 2009 Monograph.
PRECAUTIONS
General
L-methylfolate (DEPLIN) is not interchangeable with folic acid. In some patients, folic acid is not effective in influencing folic acid levels in the brain due to the low rate of transport of folic acid across the blood-brain barrier and/or low levels in the brain of an enzyme needed to convert folic acid into a biological and functional form. 7-9
Patients at risk of vitamin B12 deficiency should consult their physician before taking L-methylfolate.