What are the primary uses of Diovan. How should Diovan be taken for optimal effectiveness. What are the potential side effects of Diovan. Who should avoid taking Diovan. How does Diovan work to improve heart health. What precautions should be taken when using Diovan. How is Diovan dosage determined for different conditions.

Understanding Diovan: A Powerful Medication for Cardiovascular Health

Diovan, known generically as valsartan, is a crucial medication in the treatment of various cardiovascular conditions. As an angiotensin II receptor antagonist, it plays a vital role in managing high blood pressure, heart failure, and improving survival rates after heart attacks. But what exactly makes Diovan so effective, and how does it work within the body?

Valsartan, the active ingredient in Diovan, functions by blocking the action of natural substances that constrict blood vessels. This mechanism allows for smoother blood flow and improved heart efficiency. By doing so, Diovan helps to address several cardiovascular issues that affect millions of people worldwide.

The Science Behind Diovan’s Effectiveness

At its core, Diovan’s effectiveness lies in its ability to interact with the body’s renin-angiotensin-aldosterone system (RAAS). This complex hormonal system plays a crucial role in regulating blood pressure and fluid balance. By blocking the angiotensin II receptors, Diovan prevents the vasoconstriction and sodium retention that can lead to increased blood pressure and added strain on the heart.

Is Diovan suitable for everyone with high blood pressure. While Diovan is widely prescribed, it’s not appropriate for all patients. Individuals with certain medical conditions, such as severe liver disease or those taking specific medications, may need to avoid Diovan or use it under close medical supervision. Always consult with a healthcare provider to determine if Diovan is the right choice for your specific situation.

Key Uses of Diovan in Cardiovascular Treatment

Diovan’s versatility in treating various cardiovascular conditions makes it a valuable tool in modern medicine. Let’s explore its primary applications:

• Hypertension management in adults and children over 1 year old
• Treatment of heart failure in adults
• Improving survival rates post-heart attack
• Combination therapy with other blood pressure medications

Can Diovan be used as a standalone treatment for hypertension. In many cases, Diovan can effectively manage high blood pressure on its own. However, some patients may require a combination of medications for optimal blood pressure control. Your doctor will determine the best treatment approach based on your individual health profile and response to the medication.

Diovan in Pediatric Patients

One notable aspect of Diovan is its approval for use in children as young as 1 year old for treating high blood pressure. This makes it a valuable option for managing hypertension across a wide age range. However, pediatric dosing requires careful consideration and should always be determined by a qualified healthcare provider.

Proper Dosage and Administration of Diovan

Administering Diovan correctly is crucial for its effectiveness and safety. The dosage can vary significantly depending on the condition being treated, the patient’s age, and other individual factors.

Adult Dosage Guidelines

For adults, the typical dosage ranges are as follows:

1. Hypertension: Initial dose of 80 to 160 mg once daily, with a maintenance dose of 80 to 320 mg once daily
2. Heart Failure: Starting at 40 mg twice daily, increasing to 80 to 160 mg twice daily as tolerated
3. Post-Myocardial Infarction: Beginning with 20 mg twice daily, gradually increasing to a target of 160 mg twice daily

How quickly does Diovan start working to lower blood pressure. While some patients may experience a reduction in blood pressure within a few days of starting Diovan, it typically takes 2 to 4 weeks for the full blood pressure-lowering effect to be observed. Consistent use and regular monitoring are essential for optimal results.

Pediatric Dosing Considerations

For children aged 6 to 16 years, the initial dose is typically calculated based on body weight, starting at 1.3 mg/kg once daily (up to 40 mg). The maintenance dose can be increased up to 2.7 mg/kg (maximum 160 mg) once daily, adjusted according to the patient’s response.

What should parents know about giving Diovan to children. When administering Diovan to children, it’s crucial to follow the prescribed dosage carefully. For children who cannot swallow tablets, a pharmacist can prepare a liquid formulation. Regular check-ups and blood pressure monitoring are essential to ensure the medication is working effectively and safely.

Important Precautions and Contraindications for Diovan Use

While Diovan is generally well-tolerated, there are several important precautions and contraindications to be aware of:

• Pregnancy: Diovan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm
• Diabetes: Patients with diabetes should not take Diovan in combination with aliskiren-containing medications
• Kidney Disease: Caution is advised in patients with kidney disease, and dosage adjustments may be necessary
• Liver Disease: Patients with severe liver disease should use Diovan with caution
• Low-Salt Diet: Inform your doctor if you’re on a low-salt diet, as this can affect how your body responds to Diovan

Why is Diovan contraindicated during pregnancy. Diovan can cause serious harm to the developing fetus, particularly when used in the later stages of pregnancy. It may lead to decreased fetal renal function, oligohydramnios, and even fetal or neonatal death. Women of childbearing age should use effective contraception while taking Diovan and inform their healthcare provider immediately if they become pregnant.

Recognizing and Managing Diovan Side Effects

Like all medications, Diovan can cause side effects. While many people tolerate the medication well, it’s important to be aware of potential adverse reactions:

Common Side Effects

• Dizziness
• Headache
• Fatigue
• Abdominal pain
• Back pain
• Diarrhea

Serious Side Effects

While rare, some serious side effects require immediate medical attention:

• Severe allergic reactions (anaphylaxis)
• Kidney problems
• Liver problems
• Severe skin reactions
• Low blood pressure (hypotension)
• Hyperkalemia (high potassium levels)

How can patients distinguish between normal side effects and those requiring medical attention. While mild dizziness or headache can be common when starting Diovan, symptoms such as severe dizziness, fainting, rapid or irregular heartbeat, or signs of kidney problems (like decreased urination) warrant immediate medical attention. It’s crucial to familiarize yourself with both common and serious side effects and to maintain open communication with your healthcare provider.

Diovan Interactions: Medications and Substances to Avoid

Understanding potential drug interactions is crucial for safe and effective use of Diovan. Certain medications and substances can interact with Diovan, either enhancing its effects or increasing the risk of side effects:

Medications That May Interact with Diovan

• Other blood pressure medications, especially ACE inhibitors
• Potassium-sparing diuretics
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Lithium
• Cyclosporine
• Rifampin

Can over-the-counter pain relievers be taken safely with Diovan. While occasional use of acetaminophen is generally safe, regular use of NSAIDs like ibuprofen or naproxen may interfere with Diovan’s effectiveness and increase the risk of kidney problems. Always consult with your healthcare provider or pharmacist before combining Diovan with any over-the-counter medications.

Dietary Considerations

Certain dietary factors can also influence Diovan’s effectiveness:

• High-potassium foods: Excessive consumption may lead to hyperkalemia when combined with Diovan
• Salt substitutes: Often contain potassium and should be used with caution
• Alcohol: May enhance the blood pressure-lowering effect of Diovan, leading to dizziness or fainting

It’s important to discuss your diet and any supplements you’re taking with your healthcare provider to ensure they don’t interfere with your Diovan treatment.

Optimizing Diovan Treatment: Tips for Patients

To get the most benefit from Diovan while minimizing risks, consider the following tips:

1. Consistency is key: Take Diovan at the same time each day to maintain steady blood levels
2. Monitor your blood pressure regularly: Keep track of your readings to ensure the medication is working effectively
3. Stay hydrated: Adequate hydration helps prevent dizziness and supports kidney function
4. Avoid sudden position changes: Rise slowly from sitting or lying down to prevent dizziness
5. Maintain a healthy lifestyle: Combine Diovan with a balanced diet, regular exercise, and stress management for optimal heart health
6. Keep all medical appointments: Regular check-ups allow your doctor to monitor your progress and adjust treatment as needed

How can patients remember to take Diovan consistently. Setting a daily alarm, using a pill organizer, or linking the medication to a daily routine (like brushing teeth) can help ensure consistent dosing. Some patients find medication reminder apps helpful for managing their treatment schedule.

The Importance of Open Communication

Maintaining open communication with your healthcare provider is crucial for successful Diovan treatment. Don’t hesitate to discuss any concerns, side effects, or questions you may have about your medication. This ongoing dialogue can help ensure that your treatment plan remains effective and tailored to your individual needs.

Long-Term Outlook: Living with Diovan

For many patients, Diovan becomes a long-term part of their cardiovascular health management. Understanding what to expect can help you navigate this ongoing treatment:

Monitoring and Adjustments

Your doctor will likely schedule regular check-ups to monitor your blood pressure, kidney function, and overall health. These appointments may include:

• Blood pressure measurements
• Blood tests to check electrolyte levels and kidney function
• Discussions about any side effects or concerns
• Potential dosage adjustments based on your response to the medication

How often should patients on Diovan have their blood pressure checked. Initially, more frequent monitoring (every 2-4 weeks) may be necessary. Once your blood pressure stabilizes, checks every 3-6 months are typically sufficient, but your doctor will provide personalized recommendations based on your individual health status.

Lifestyle Considerations

While Diovan can effectively manage blood pressure and heart health, combining it with healthy lifestyle choices can enhance its benefits:

• Maintain a heart-healthy diet low in sodium and rich in fruits, vegetables, and whole grains
• Engage in regular physical activity as approved by your doctor
• Manage stress through relaxation techniques or mindfulness practices
• Limit alcohol consumption and avoid tobacco use
• Maintain a healthy weight

Can lifestyle changes reduce the need for Diovan over time. In some cases, significant lifestyle improvements may allow for a reduction in medication dosage. However, never adjust your Diovan dosage without consulting your healthcare provider. Any changes to your treatment plan should be made under medical supervision to ensure your cardiovascular health remains well-managed.

Diovan in Special Populations: Considerations and Adaptations

While Diovan is widely used, its application in certain populations requires special consideration:

Elderly Patients

Older adults may be more sensitive to the effects of Diovan and may require lower initial doses. Factors to consider include:

• Increased risk of orthostatic hypotension
• Potential for reduced kidney function
• Higher likelihood of concomitant medications that may interact with Diovan

Patients with Renal Impairment

For individuals with kidney problems, dosage adjustments may be necessary:

• Mild to moderate renal impairment: No initial dosage adjustment is usually required
• Severe renal impairment: Lower starting doses are recommended, with careful monitoring of kidney function
• Patients on dialysis: Limited data available; use with caution

How does kidney function affect Diovan dosing. The kidneys play a crucial role in eliminating Diovan from the body. In patients with impaired kidney function, the drug may accumulate, potentially leading to increased side effects. Therefore, dosage adjustments and close monitoring are essential to ensure safe and effective treatment in these individuals.

Pediatric Use

While Diovan is approved for use in children over 1 year old, special considerations apply:

• Dosing is typically based on body weight
• The safety and efficacy in children under 6 years old have not been established for certain indications
• Growth and development should be monitored during long-term use

These special populations highlight the importance of individualized treatment approaches when using Diovan. Healthcare providers must carefully consider each patient’s unique circumstances to optimize the benefits of Diovan while minimizing potential risks.

Diovan Uses, Dosage & Side Effects

Generic name: valsartan [ val-SAR-tan ]
Drug class: Angiotensin receptor blockers

Medically reviewed by Kaci Durbin, MD. Last updated on Jul 11, 2023.

What is Diovan?

Diovan is used in adults and in children 1 year of age and older alone or in combination with other medications to treat high blood pressure.

Diovan is also used in adults to treat heart failure (a condition in which the heart is unable to pump enough blood to the rest of the body) and to improve survival after a heart attack.

Diovan belomgs to a class of medications called angiotensin II receptor antagonists. Valsartan works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently.

Warnings

Do not use Diovan if you are pregnant. Stop using this medicine and tell your doctor right away if you become pregnant.

If you have diabetes, do not take Diovan with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking Diovan with aliskiren if you have kidney disease.

In rare cases, Diovan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Before taking this medicine

You should not use Diovan if you are allergic to valsartan.

If you have diabetes, do not take Diovan with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking Diovan with aliskiren if you have kidney disease.

To make sure Diovan is safe for you, tell your doctor if you have ever had:

• a heart condition other than one being treated with Diovan;

• if you are on a low-salt diet;

• liver disease; o

• kidney disease (or if you are on dialysis).

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

Do not breastfeed.

How should I take Diovan?

Take Diovan exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Take the medicine at the same time each day, with or without food.

For a child who cannot swallow a tablet whole, a pharmacist can mix the medicine into a liquid.

Your dose needs may change if you switch to a different form of valsartan. Avoid medication errors by using only the medicine your doctor prescribes.

Doses are based on weight in children and teenagers. Your child’s dose may change if the child gains or loses weight.

Your blood pressure will need to be checked often. Your kidney function may also need to be checked.

Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking Diovan.

It may take 2 to 4 weeks before your blood pressure is under control. If you have high blood pressure, keep using Diovan even if you feel well. High blood pressure often has no symptoms.

Your treatment may also include diet, exercise, lifestyle changes, and other medications. Follow your doctor’s instructions very carefully.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 40 mg orally twice a day
Maintenance dose: 80 to 160 mg twice a day. The dose should be increased to the highest dose tolerated by the patient.

Usual Adult Dose for Hypertension:

Initial dose: 80 to 160 mg orally once a day.
Maintenance dose: 80 to 320 mg orally once a day

Usual Adult Dose for Myocardial Infarction:

Initial dose: 20 mg orally twice a day
Maintenance dose: The initial dosage may be titrated upward within 7 days to 40 mg twice daily, with subsequent titrations to a target maintenance dose of 160 mg twice a day as tolerated by the patient. If symptomatic hypotension or renal dysfunction occurs, consideration should be given to a dosage reduction.

Comment: Valsartan may be initiated as early as 12 hours after a myocardial infarction, and may be given with other standard postmyocardial infarction treatment, including thrombolytics, aspirin, beta blockers, and statins.

Usual Pediatric Dose for Hypertension:

6 to 16 years:
Initial dose: 1.3 mg/kg once a day (up to 40 mg)
Maintenance dose: up to 2.7 mg/kg (up to 160 mg) once a day titrated according to patient response

Comments:
-If the calculated dosage does not correspond to the available tablet strengths, or if children are unable to swallow tablets, the use of a suspension (which can be prepared from the tablets) is recommended. The valsartan dose may need to be increased if the suspension is replaced by a tablet.
-No data are available in pediatric patients either undergoing dialysis or with a glomerular filtration rate less than 30 mL/min.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include irregular heart rate or low blood pressure (feeling like you might pass out).

What should I avoid while taking Diovan?

Do not take potassium supplements or use salt substitutes, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Diovan side effects

Get emergency medical help if you have signs of an allergic reaction to Diovan: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Diovan may cause serious side effects. Call your doctor at once if you have:

• a light-headed feeling, like you might pass out;

• little or no urination; or

• high blood potassium – nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.

Common Diovan side effects may include:

• high blood potassium;

• headache, dizziness, feeling light-headed;

• cough, flu symptoms, tiredness;

• stomach pain, diarrhea;

• back pain, joint pain; or

• abnormal kidney test.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Diovan?

Tell your doctor about all your other medicines, especially:

• lithium;

• cyclosporine;

• ritonavir;

• an antibiotic – rifamycin, rifabutin, rifampin, rifapentine;

• a diuretic or “water pill” or other heart or blood pressure medication; or

• NSAIDs (nonsteroidal anti-inflammatory drugs) – aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete and many other drugs may interact with valsartan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Ingredients

Active ingredient: valsartan.
Inactive ingredients: colloidal silicon dioxide, crospovidone, hydroxypropyl methylcellulose, iron oxides (yellow, black and/or red), magnesium stearate, microcrystalline cellulose, polyethylene glycol 8000, and titanium dioxide.

Manufacturer

Distributed by: Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA.

Frequently asked questions

• Losartan vs Valsartan – What’s the difference between them?
• What is the strength of Prexxartan (valsartan) oral solution?

References

1. Diovan Product Label

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Related treatment guides

• High Blood Pressure
• Heart Attack
• Heart Failure
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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Diovan only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 18.02.

Diovan oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor right away.

How to use Diovan

Read the Patient Information Leaflet if available from your pharmacist before you start taking valsartan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well for at least 10 seconds before each dose.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Tell your doctor if you do not get better or if you get worse (for example, your blood pressure readings remain high or increase).

Side Effects

Dizziness or lightheadedness may occur as your body adjusts to the medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: fainting, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat).

Although valsartan may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking valsartan. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking valsartan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, dehydration, high level of potassium in the blood.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

Liquid products may contain sugar and/or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using valsartan. Valsartan may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. (See also Warning section.)

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Consult your pharmacist or physician.

Interactions

See also Precautions section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: aliskiren, lithium, drugs that may increase the level of potassium in the blood (such as sparsentan, ACE inhibitors including benazepril/lisinopril, birth control pills containing drospirenone).

Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

Does Diovan interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, fainting.

Do not share this medication with others.

Lifestyle changes that may help this medication work better include exercising, stopping smoking, and eating a low-cholesterol/low-fat diet. Consult your doctor for more details.

Lab and/or medical tests (such as kidney function tests, potassium levels) should be done while you are taking this medication. Keep all medical and lab appointments.

Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure, and share the results with your doctor.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store this medication at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

If you are using the suspension form of this medication, store it at room temperature for up to 30 days, or in the refrigerator for up to 75 days. Do not freeze.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Diovan 320 mg tablet

Color: dark grayish violetShape: almondImprint: DXL NVR

This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.

Diovan 160 mg tablet

Color: gray orangeShape: almondImprint: DX NVR

This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.

Diovan 80 mg tablet

Color: pale redShape: almondImprint: DV NVR

This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.

Diovan 40 mg tablet

Color: yellowShape: ovalImprint: NVR D O

This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Diovan instructions for use: indications, contraindications, side effects – description Diovan tab., cover. shell, 80 mg: 14, 28, 56 or 98 pcs. (260)

💊 Composition of Diovan ® ✅ Application of Diovan ® Keep it for yourself Look for alternatives Interaction Description of the active ingredients of the preparation Diovan ® (Diovan ® ) The scientific information provided is general and cannot be used to make decisions. decisions about the use of a particular drug. Update date: 2020.03.25 Marketing authorization holder: NOVARTIS PHARMA, AG (Switzerland) Manufactured: NOVARTIS PHARMA STEIN, AG (Switzerland) ATX code: C09CA03 (Valsartan) Active substance: valsartan (valsartan) Rec.INN WHO registered Dosage form Diovan ® Tab. , coated shell, 80 mg: 14, 28, 56 or 98 pcs. reg. No.: P N013991/01 dated 13.11.09 – Indefinitely Date of re-registration: 16.02.16 Release form, packaging and composition Diovan ® Tablets, film-coated pale pink, round, with beveled edges, scored on one side and embossed with “D/V”, on the other side with “NVR”. Excipients : microcrystalline cellulose, crospovidone, anhydrous colloidal silicon dioxide, magnesium stearate, hypromellose (hydroxypropyl methylcellulose), macrogol 8000, titanium dioxide (E171), iron oxide red (E172), iron oxide yellow (E172). 14 pcs. – blisters (1) – packs of cardboard. 14 pcs. – blisters (2) – packs of cardboard. 14 pcs. – blisters (4) – packs of cardboard. 14 pcs. – blisters (7) – packs of cardboard. Clinical and pharmacological group: Angiotensin II receptor antagonist Pharmacotherapeutic group: Angiotensin II receptor antagonist Pharmacological action Antihypertensive agent. It is a specific angiotensin II receptor antagonist. It has a selective antagonistic effect on AT 1 – receptors that are responsible for the implementation of the effects of angiotensin II. Due to the blockade of AT 1 receptors, the plasma concentration of angiotensin II increases, which can stimulate unblocked AT 2 receptors. Does not have agonistic activity against AT 1 receptors. The affinity of valsartan for the AT 1 receptor is approximately 20,000 times higher than for the AT 2 receptor. Does not inhibit ACE. Does not interact with or block other hormone receptors or ion channels that are important for the regulation of the functions of the cardiovascular system. Does not affect the level of total cholesterol, TG, glucose and uric acid in plasma. The onset of the antihypertensive effect of valsartan after oral administration in a single dose is observed within 2 hours after administration, the maximum effect is achieved within 4-6 hours. Absolute bioavailability averages 23%. The pharmacokinetic curve of valsartan has a multi-exponential character (T 1/2 in the α-phase < 1 h and T 1/2 in the β-phase – about 9 h), the kinetics is linear. There were no changes in pharmacokinetic parameters during the course application. When taking valsartan with food, AUC decreases by 48%, while approximately 8 hours after taking valsartan plasma concentrations are the same in patients who took it with food and on an empty stomach. The decrease in AUC is not accompanied by a clinically significant decrease in the therapeutic effect. When taking valsartan 1 time / day, cumulation is slightly pronounced. Plasma concentrations of valsartan in women and men were the same. Plasma protein binding, predominantly to albumin, is 94-97%. V d in the equilibrium state is about 17 liters. Plasma clearance of valsartan is about 2 l/h. Excreted with feces – 70% and with urine – 30%, mainly unchanged. In biliary cirrhosis or obstruction of the biliary tract, the AUC of valsartan increases by approximately 2 times. Indications of the active substances of the drug Diovan ® Treatment of arterial hypertension. Treatment of chronic heart failure (NYHA functional class II-IV) in patients receiving conventional therapy with diuretics, digitalis preparations, and ACE inhibitors or beta-blockers. Open list of ICD-10 codes I10 Essential [primary] hypertension I50. 0 Congestive heart failure Dosing regimen The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. Take orally at a dose of 80 mg 1 time / day or 40 mg 2 times / day, daily. In the absence of an adequate effect, the daily dose may be gradually increased. The maximum daily dose of is 320 mg in 2 divided doses. Side effects From the side of the cardiovascular system: arterial hypotension, postural dizziness, postural hypotension. From the side of the central nervous system: dizziness, headache. From the digestive system: diarrhea, nausea, increased bilirubin levels. From the urinary system: rarely – impaired renal function, increased levels of creatinine and urea nitrogen (especially in chronic heart failure). From the side of metabolism: hyperkalemia. From the side of the hematopoietic system: neutropenia, decrease in hemoglobin and hematocrit. Allergic reactions: rarely – angioedema, rash, itching, serum sickness, vasculitis. Other: fatigue, general weakness, cough, pharyngitis, increased risk of viral infections. Contraindications for use Pregnancy, hypersensitivity to valsartan. Use in pregnancy and lactation Valsartan is contraindicated in pregnancy. It is not known whether valsartan is excreted in human breast milk. Use during lactation (breastfeeding) is not recommended. In experimental studies valsartan has been shown to be excreted in breast milk in rats. Use in impaired renal function In patients with renovascular hypertension secondary to renal artery stenosis, serum urea and creatinine levels should be monitored regularly during treatment. Data on the safety of use in patients with CC less than 10 ml / min are not available. Due to inhibition of the RAAS in predisposed patients, changes in renal function are possible. Use in children The safety and efficacy of valsartan in children has not been established. Special instructions With hyponatremia and / or a decrease in BCC, as well as during therapy with high doses of diuretics, in rare cases, valsartan can cause severe arterial hypotension. Before starting treatment, correction of water-salt metabolism disorders should be carried out. In patients with renovascular hypertension secondary to renal artery stenosis, serum urea and creatinine levels should be regularly monitored during treatment. Data on the safety of use in patients with CC less than 10 ml / min are not available. Use with extreme caution in patients with biliary obstruction. Due to inhibition of the RAAS in predisposed patients, changes in renal function are possible. When using ACE inhibitors and angiotensin receptor antagonists in patients with severe chronic heart failure, oliguria and / or an increase in azotemia were observed, and acute renal failure with a risk of death rarely developed. The safety and efficacy of valsartan in children has not been established. Influence on the ability to drive vehicles and mechanisms When using valsartan, it is recommended to be careful when driving a car and operating mechanisms. Drug interactions With the simultaneous use of diuretics in high doses, arterial hypotension may develop. With the simultaneous use of potassium-sparing diuretics, heparin, dietary supplements or salt substitutes containing potassium, hyperkalemia may develop. Co-administration with indomethacin may reduce the antihypertensive effect of valsartan. When used simultaneously with lithium carbonate, a case of lithium intoxication has been described. Keep If you want to place a link to the description of this drug – use this code Diovan ® . Description of the drug in the reference book Vidal.

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