What is Dramamine II and how does it work. How to use meclizine safely for motion sickness and vertigo. What are the potential side effects and drug interactions of Dramamine II. How does meclizine compare to other antihistamines for dizziness and nausea. When should you consult a doctor before taking Dramamine II.

Understanding Dramamine II: Meclizine for Motion Sickness and Vertigo

Dramamine II, known generically as meclizine, is a prescription medication used to prevent and control nausea, vomiting, and dizziness caused by motion sickness. It’s also effective for treating vertigo, a condition characterized by dizziness or lightheadedness due to ear problems. As an antihistamine, meclizine works by blocking signals to the brain that cause these uncomfortable symptoms.

How does meclizine differ from other antihistamines? Unlike some over-the-counter options, meclizine is specifically designed to target motion sickness and vertigo symptoms. Its unique mechanism of action makes it a preferred choice for many patients who struggle with these conditions.

The Science Behind Meclizine: How It Combats Dizziness and Nausea

Meclizine belongs to the drug class of anticholinergic antiemetics. Its primary function is to inhibit the stimulation of certain receptors in the brain and inner ear that are responsible for causing nausea, vomiting, and dizziness. By doing so, it helps maintain balance and reduce the uncomfortable sensations associated with motion sickness and vertigo.

Why is meclizine effective for both motion sickness and vertigo? The underlying causes of these conditions are related to disturbances in the vestibular system, which is responsible for our sense of balance. Meclizine’s ability to modulate this system makes it versatile in treating various forms of dizziness and nausea.

Key Benefits of Meclizine:

• Prevents and controls nausea and vomiting
• Reduces dizziness associated with motion sickness
• Alleviates vertigo symptoms caused by inner ear problems
• Provides longer-lasting relief compared to some other antihistamines

Proper Usage and Dosage Guidelines for Dramamine II

To ensure the safe and effective use of Dramamine II, it’s crucial to follow the prescribed dosage and administration guidelines. Typically, meclizine is taken orally, with or without food, as directed by your healthcare provider.

Is there a standard dosage for Dramamine II? The dosage can vary depending on the specific condition being treated and individual factors. For motion sickness, a common adult dose is 25-50 mg taken one hour before travel. For vertigo, dosages may range from 25-100 mg per day, divided into several doses.

Important Dosage Considerations:

1. Always follow your doctor’s instructions or the label directions
2. Do not exceed the recommended dosage
3. If you miss a dose, take it as soon as you remember, unless it’s close to the time for your next dose
4. Avoid doubling up on doses to make up for a missed one

Potential Side Effects and Precautions When Taking Meclizine

While Dramamine II is generally well-tolerated, like all medications, it can cause side effects in some individuals. It’s important to be aware of these potential effects and to consult your healthcare provider if you experience any concerning symptoms.

What are the most common side effects of meclizine? The most frequently reported side effects include drowsiness, dry mouth, and blurred vision. These effects are usually mild and often subside as your body adjusts to the medication.

Common Side Effects:

• Drowsiness or fatigue
• Dry mouth
• Blurred vision
• Headache
• Constipation

Are there any serious side effects to watch for? While rare, some individuals may experience more severe reactions. Seek immediate medical attention if you develop signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.

Drug Interactions and Contraindications: What to Avoid with Dramamine II

Meclizine can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking before starting Dramamine II.

Which substances should be avoided while taking meclizine? Alcohol and other central nervous system depressants can enhance the sedative effects of meclizine and should be avoided or used with caution. Additionally, certain medications may interact with meclizine, including:

• Potassium citrate
• Tranylcypromine
• Some antidepressants and antipsychotics
• Certain pain medications and sedatives

Can meclizine be taken during pregnancy or while breastfeeding? While studies suggest minimal risk to infants when used during breastfeeding, it’s essential to consult your doctor before using meclizine if you’re pregnant or nursing.

Special Considerations for Elderly Patients and Children

The use of Dramamine II may require special considerations for certain age groups. Elderly patients and children may have different responses to the medication, and dosage adjustments might be necessary.

Is Dramamine II safe for older adults? While meclizine can be effective for elderly patients, they may be more sensitive to its effects. Older adults are also more likely to have age-related liver, kidney, or heart problems, which may necessitate dosage adjustments or additional monitoring.

Can children use Dramamine II? The safety and efficacy of meclizine have not been established in children younger than 12 years old for certain formulations. It’s crucial to consult a pediatrician before administering meclizine to children.

Age-Related Considerations:

• Elderly patients may require lower doses due to increased sensitivity
• Children under 12 should only use meclizine under direct medical supervision
• Monitoring for side effects is crucial in both elderly patients and children

Comparing Dramamine II to Other Motion Sickness Medications

While Dramamine II is a popular choice for motion sickness and vertigo, it’s not the only option available. Understanding how it compares to other medications can help you and your healthcare provider make an informed decision about the best treatment for your symptoms.

How does meclizine compare to dimenhydrinate (original Dramamine)? Meclizine tends to have a longer duration of action and may cause less drowsiness than dimenhydrinate. However, individual responses can vary, and some people may find one more effective than the other.

Comparison of Common Motion Sickness Medications:

• Meclizine (Dramamine II): Longer-lasting, may cause less drowsiness
• Dimenhydrinate (original Dramamine): Faster onset, but shorter duration
• Scopolamine (transdermal patch): Long-lasting prevention, but requires prescription
• Ginger: Natural alternative, may help with mild nausea

Which medication is best for severe motion sickness? For individuals with severe or persistent motion sickness, prescription options like scopolamine patches or higher doses of meclizine might be more appropriate. Always consult your healthcare provider to determine the best option for your specific needs.

Tips for Maximizing the Effectiveness of Dramamine II

To get the most benefit from Dramamine II, it’s important to use it correctly and in conjunction with other motion sickness prevention strategies. Here are some tips to enhance its effectiveness:

1. Take the medication at least 1 hour before travel or anticipated motion exposure
2. Stay hydrated and avoid heavy meals before and during travel
3. Choose a seat where motion is felt least (e.g., over the wing in an airplane)
4. Focus on a stable horizon or close your eyes to reduce visual stimuli
5. Ensure proper ventilation in your travel environment

Can lifestyle changes complement the use of Dramamine II? Absolutely. Practicing relaxation techniques, gradually exposing yourself to motion, and maintaining a healthy diet can all contribute to better management of motion sickness and vertigo symptoms.

Additional Strategies to Combat Motion Sickness:

• Use acupressure wristbands
• Try ginger supplements or tea in addition to medication
• Avoid reading or using electronic devices during travel
• Get plenty of rest before your journey

By combining these strategies with the proper use of Dramamine II, you can significantly reduce the impact of motion sickness and vertigo on your daily life and travel experiences.

Dramamine II Advanced Patient Information

Generic name: meclizine [ MEK-li-zeen ]
Drug class: Anticholinergic antiemetics

Medically reviewed by Drugs.com. Last updated on Jul 14, 2022.

Uses for Dramamine II

Meclizine is used to prevent and control nausea, vomiting, and dizziness caused by motion sickness. It is also used for vertigo (dizziness or lightheadedness) caused by ear problems.

Meclizine is an antihistamine. It works to block the signals to the brain that cause nausea, vomiting, and dizziness.

This medicine is available only with your doctor’s prescription.

Before using Dramamine II

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Antivert® tablets and chewable tablets in children or Antivert®/25 or Antivert®/50 tablets in children younger than 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of meclizine in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving meclizine.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Potassium Citrate
• Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil
• Alprazolam
• Amantadine
• Amifampridine
• Amobarbital
• Anileridine
• Benzhydrocodone
• Bromazepam
• Buprenorphine
• Bupropion
• Buspirone
• Butabarbital
• Butorphanol
• Calcium Oxybate
• Cannabidiol
• Cannabis
• Cetirizine
• Chloral Hydrate
• Chlordiazepoxide
• Chlorpromazine
• Clobazam
• Clonazepam
• Clorazepate
• Clozapine
• Codeine
• Daridorexant
• Dexmedetomidine
• Diazepam
• Difenoxin
• Dihydrocodeine
• Diphenhydramine
• Diphenoxylate
• Donepezil
• Doxylamine
• Esketamine
• Estazolam
• Eszopiclone
• Ethchlorvynol
• Ethylmorphine
• Fentanyl
• Flibanserin
• Flurazepam
• Fospropofol
• Gabapentin
• Gabapentin Enacarbil
• Glucagon
• Glycopyrrolate
• Glycopyrronium Tosylate
• Halazepam
• Hydrocodone
• Hydromorphone
• Hydroxyzine
• Ketamine
• Ketazolam
• Ketobemidone
• Lacosamide
• Lemborexant
• Levocetirizine
• Levorphanol
• Lofexidine
• Lorazepam
• Loxapine
• Magnesium Oxybate
• Meperidine
• Meprobamate
• Methacholine
• Methadone
• Methotrimeprazine
• Metoclopramide
• Midazolam
• Morphine
• Morphine Sulfate Liposome
• Nalbuphine
• Nicomorphine
• Nitrazepam
• Opium
• Opium Alkaloids
• Oxazepam
• Oxycodone
• Oxymorphone
• Papaveretum
• Paregoric
• Pentazocine
• Pentobarbital
• Periciazine
• Phenobarbital
• Piritramide
• Pitolisant
• Potassium Oxybate
• Prazepam
• Pregabalin
• Promethazine
• Propofol
• Propoxyphene
• Quazepam
• Quetiapine
• Ramelteon
• Remimazolam
• Revefenacin
• Ropeginterferon Alfa-2b-njft
• Scopolamine
• Secobarbital
• Secretin Human
• Sodium Oxybate
• Sufentanil
• Tapentadol
• Temazepam
• Thioridazine
• Tilidine
• Tiotropium
• Topiramate
• Tramadol
• Trazodone
• Triazolam
• Zaleplon
• Zolpidem
• Zopiclone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Asthma or
• Enlarged prostate or
• Glaucoma—Use with caution. May make these conditions worse.

• Kidney disease or
• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper use of Dramamine II

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Chew or crush the chewable tablet completely before swallowing. Do not swallow it whole.

Swallow the non-chewable tablet whole. Do not crush, chew, or break it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  • For nausea, vomiting, and dizziness caused by motion sickness:
    • Adults—At first, 25 to 50 milligrams (mg) taken 1 hour before travel. You may take another dose once every 24 hours while traveling.
    • Children 12 years of age and older—Use and dose must be determined by your doctor.
    • Children younger than 12 years of age—Use is not recommended.
  • For vertigo:
    • Adults—25 to 100 milligrams (mg) per day, taken in divided doses.
    • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using Dramamine II

It is very important that your doctor check your or your child’s progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

This medicine may cause some people to become drowsy or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, antidepressants, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you or your child are using this medicine.

Side Effects of Dramamine II

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Cough
• difficulty swallowing
• dizziness
• drowsiness
• fast heartbeat
• hives, itching, skin rash
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• tightness in the chest
• unusual tiredness or weakness
• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• Blurred vision

Incidence not known

• Dry mouth
• headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

More about Dramamine II (meclizine)

• Check interactions
• Compare alternatives
• Reviews (7)
• Side effects
• Dosage information
• During pregnancy
• Drug class: anticholinergic antiemetics
• Breastfeeding

Patient resources

Other brands

Antivert, Bonine, Meclicot, Meni-D, … +2 more

Professional resources

• Prescribing Information

Other formulations

• Dramamine
• Dramamine Less Drowsy

Related treatment guides

• Motion Sickness
• Nausea/Vomiting
• Vertigo

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Medicine-induced Vertigo

Published: 2 March 2017

This article is more than five years old. Some content may no
longer be current.

Prescriber Update 38(1): 12-13

March 2017

Key Messages

• Consider the possibility of a medicine-related cause in patients
  presenting with vertigo.
• Many different types of medicines may cause vertigo.
• Some medicines that cause vertigo are also ototoxic.
• When reporting cases of ‘vertigo’ to CARM, it is helpful to
  differentiate between true vertigo and other sensations of ‘dizziness’.

Vertigo has a number of possible causes, most commonly vestibular neuritis,
benign paroxysmal positional vertigo (BPPV) or vestibular migraine, but
it can also be caused by medicines^1,2.

Vertigo is a sensation of motion either of the body or the surrounding
environment. It occurs when the brain receives conflicting visual, proprioceptive
and vestibular information about one’s position in space³.

Vertigo is often described by patients as ‘dizziness’, a non-specific
term used to express a variety of sensations that may also include light-headedness,
faintness and imbalance, all of which have many possible causes. It is important
to distinguish between these symptoms as the cause and management may differ.

Medicines known to Cause Vertigo

A variety of medicines have been associated with vertigo (Table 1).

Some medicines that cause vertigo are also ototoxic (eg, aminoglycosides,
anti-inflammatory medicines, phosphodiesterase type-5 inhibitors, furosemide).
When a patient who is taking a medicine known to be ototoxic presents with
vertigo, dose reduction or discontinuation of the medicine may need to be
considered to prevent irreversible hearing loss.

Table 1. Examples of medicines that may cause vertigo (this is
not an exhaustive list)

Cases of Vertigo Reported to CARM

The Centre for Adverse Reactions Monitoring (CARM) received 98 case reports
of vertigo from 1 January 2006 to 31 December 2015.

The most frequently reported medicine was influenza trivalent vaccine
(11 reports). However, only three of the reports gave a clear description
of vertigo. In one of these cases, vertigo was associated with severe headache
and weakness on one side. In the remaining eight cases, the term vertigo
has been used, but it is not clear from the case description whether it
was true vertigo or dizziness.

The second most frequently reported medicine was thyroxine (eight reports).
The majority of these cases appear to be related to a change in formulation
that was introduced in September 2007.

The next most frequently reported medicines are simvastatin (five reports),
venlafaxine (five) and omeprazole (four).

As is often the case for medicines with an established safety profile,
cases of vertigo associated with medicines that are well known to cause
vertigo (eg, aminoglycosides), are rarely reported to CARM.

Vertigo is not listed as an adverse effect in the data sheets of the
majority of medicines in the cases reported to CARM. However, it is worth
noting, ‘dizziness’ is listed as an adverse effect.

When reporting cases of ‘vertigo’ to CARM, it is helpful to differentiate
between true vertigo and other forms of ‘dizziness’. A description of the
patient’s symptoms is useful, particularly whether or not the patient experienced
a sense of motion (eg, ‘felt that the room was spinning’). This helps CARM
and Medsafe to identify whether any update to the medicine’s data sheet
is necessary and any further communication is required.

References

1. Drug-induced true vertigo and balance disorders. 2015. Prescrire
   International. 24(156): 18.
2. Best Practice Advocacy Centre (BPAC). 2012. A delicate balance:
   managing vertigo in general practice. URL:
   
   www. bpac.org.nz/BPJ/2012/september/vertigo.aspx (accessed
   22 October 2016).
3. Walker B, Colledge N, Ralston S, et al. 2014. Davidson’s Principles
   and Practice of Medicine 22^nd edition. Edinburgh: Churchill
   Livingstone.

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