What are the potential side effects of DMSO cream. How does dimethyl sulfoxide affect the human body. What risks should be considered when using DMSO for medical purposes. What does current research say about DMSO’s safety profile.

The Origins and Discovery of Dimethyl Sulfoxide (DMSO)

Dimethyl sulfoxide, commonly known as DMSO, has an intriguing history that dates back to the late 19th century. This colorless chemical solvent was first discovered in Germany as a by-product of the paper-making process. Its unique ability to penetrate biological membranes, including human skin, caught the attention of scientists in the 1960s. This property led researchers to explore DMSO’s potential as a transport mechanism for small molecules through the skin, opening up new avenues for medical research and applications.

Key Milestones in DMSO Research

• Late 19th century: DMSO discovered in Germany
• 1960s: Scientists recognize DMSO’s ability to penetrate biological membranes
• Late 1970s: FDA approves DMSO for treating interstitial cystitis
• Ongoing: Research continues into various potential medical applications

FDA-Approved Uses of DMSO: Focusing on Interstitial Cystitis

While DMSO has been studied for various medical applications, it currently has only one FDA-approved use. The Food and Drug Administration has sanctioned DMSO under the brand name RIMSO-50 for the treatment of interstitial cystitis, a chronic bladder condition. This approval came in the late 1970s, making DMSO the only FDA-approved bladder installation (or bladder wash) for this specific condition.

Benefits of DMSO for Interstitial Cystitis Patients

For individuals suffering from interstitial cystitis, DMSO has demonstrated several beneficial effects:

• Pain relief associated with the condition
• Relaxation of the bladder muscles
• Increase in bladder capacity

These effects can significantly improve the quality of life for patients dealing with this chronic bladder issue. However, it’s crucial to note that DMSO should only be used under medical supervision for this approved purpose.

Off-Label Uses and Potential Benefits of DMSO

Beyond its FDA-approved use, DMSO has been explored for various off-label applications. While these uses are not officially sanctioned, some researchers and alternative medicine practitioners have investigated DMSO’s potential benefits in treating other conditions.

Conditions Potentially Treated with DMSO

• Arthritis
• Cancer
• Chemotherapy side effects
• General pain management

One of the primary reasons for DMSO’s exploration in these areas is its ability to absorb easily into the skin. This property has led some to consider it as an alternative treatment for reducing inflammation and pain. However, it’s important to emphasize that more research is needed to substantiate these potential benefits and determine their efficacy and safety.

DMSO in Cancer Research

Recent studies have begun to explore DMSO’s potential role in cancer treatment. A 2020 study published in the Journal of Medical Discovery found evidence suggesting that DMSO might have benefits in inhibiting cancer cells. However, this research is still in its early stages, and much more extensive studies are required before any definitive conclusions can be drawn about DMSO’s efficacy in cancer treatment.

Common Side Effects of DMSO Usage

While DMSO is generally considered to have a relatively mild side effect profile, it’s important to understand that the severity of reactions can be directly correlated to the amount of DMSO used. Users should be aware of potential adverse effects, which can range from minor discomfort to more significant health concerns.

Mild Side Effects

One of the most commonly reported side effects of DMSO use is a distinct taste of garlic in the mouth and throat. This unusual sensation is often described as persistent and can be quite noticeable to users.

More Severe Side Effects

In some cases, users may experience more significant side effects, including:

• Headache
• Nausea and vomiting
• Stomach discomfort
• Diarrhea
• Fever and chills
• Decreased heart rate
• Skin reactions (itching, rash, or changes in skin texture)

It’s crucial to note that these more severe side effects are often associated with higher doses or prolonged use of DMSO. As with any medication or treatment, it’s essential to use DMSO only as directed by a healthcare professional.

Potential Risks and Drug Interactions with DMSO

While DMSO has gained popularity as an alternative treatment option, its easy availability online poses potential risks. Using DMSO without proper medical supervision can increase the likelihood of overuse and associated complications.

Drug Interactions

DMSO may interact with certain medications, potentially amplifying their effects. This interaction could lead to serious reactions in some individuals. Medications that may be affected by DMSO include:

• Sedatives
• Blood thinners
• Steroids

Given these potential interactions, it’s crucial for individuals considering DMSO use to consult with a healthcare provider, especially if they are taking any other medications.

Administration Methods and Dosage Considerations for DMSO

DMSO can be administered through various methods, depending on its intended use and the condition being treated. The most common forms of administration include:

• Topical application: via gel or solution
• Bladder wash: via catheter (specifically for interstitial cystitis)

Dosage is a critical factor in DMSO use, as it directly correlates with the potential for side effects. Higher doses or more frequent applications may increase the risk of adverse reactions. Therefore, it’s essential to follow professional medical advice regarding dosage and application frequency.

Importance of Professional Guidance

Given the potential risks and the importance of proper dosing, it’s strongly advised to consult with a healthcare professional before using any product containing DMSO. This guidance is especially crucial for individuals considering DMSO for off-label uses or as an alternative treatment option.

Current Research and Future Prospects of DMSO in Medicine

The medical community continues to explore the potential applications of DMSO, with ongoing research focusing on its efficacy and safety in various treatments. While some studies have shown promising results, it’s important to approach these findings with caution and await more comprehensive research.

Areas of Current DMSO Research

• Pain management and inflammation reduction
• Cancer cell inhibition
• Chemotherapy side effect mitigation
• Drug delivery enhancement

One area of particular interest is DMSO’s potential role in reducing chemotherapy-related complications. Some studies have investigated its ability to minimize leakage during chemotherapy administration, potentially reducing tissue damage. However, more extensive research and real-world trials are needed before DMSO can be considered a trusted method in this context.

Future Prospects and Challenges

As research continues, scientists face several challenges in fully understanding and harnessing the potential of DMSO:

1. Establishing a comprehensive safety profile for long-term use
2. Determining optimal dosages for various applications
3. Investigating potential interactions with a wider range of medications
4. Conducting large-scale clinical trials for off-label uses

The future of DMSO in medicine remains an open question, with ongoing research potentially uncovering new applications while also shedding light on any long-term risks or limitations.

Regulatory Landscape and Accessibility of DMSO

The regulatory status of DMSO varies depending on its intended use and the country in question. In the United States, its FDA-approved use is limited to treating interstitial cystitis. However, the compound’s availability extends beyond this narrow application.

Over-the-Counter Availability and Associated Risks

DMSO is readily available for purchase online and in some stores, often marketed as an alternative treatment or supplement. This easy accessibility raises concerns about potential misuse or overuse by individuals without proper medical guidance. The risks associated with unsupervised use include:

• Incorrect dosing leading to increased side effects
• Potential interactions with other medications
• Use for unapproved conditions without sufficient scientific backing
• Delay in seeking appropriate medical treatment for serious conditions

Given these risks, healthcare professionals and regulatory bodies often caution against the unsupervised use of DMSO, especially for off-label purposes.

International Regulations

The regulatory status of DMSO can vary significantly between countries. While some nations may have similar restrictions to the United States, others might have more lenient or more stringent regulations. Individuals considering DMSO use should be aware of the legal status and regulations in their specific location.

Patient Considerations and Best Practices for DMSO Use

For individuals considering DMSO as a treatment option, whether for its approved use in interstitial cystitis or for off-label applications, several important considerations should be kept in mind:

Consultation with Healthcare Providers

Before initiating DMSO use, it’s crucial to consult with a qualified healthcare provider. This step ensures that:

• The potential benefits and risks are thoroughly evaluated
• Any possible drug interactions are identified and addressed
• Proper dosing and administration methods are determined
• Alternative treatment options are considered when appropriate

Monitoring and Reporting Side Effects

Patients using DMSO should be vigilant about monitoring for any side effects or unusual reactions. It’s important to:

1. Keep a record of any symptoms or changes experienced during DMSO use
2. Report any concerning side effects to a healthcare provider promptly
3. Follow up regularly with medical professionals to assess the treatment’s efficacy and safety

By adhering to these best practices, patients can maximize the potential benefits of DMSO while minimizing risks and ensuring their overall health and safety.

Uses, Benefits, Risks, and More

DMSO (Dimethyl Sulfoxide): Uses, Benefits, Risks, and More

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Medically reviewed by Angelica Balingit, MD — By Jessica DiGiacinto and Joe Bowman — Updated on May 16, 2023

DMSO is a colorless chemical solvent that may have many medical uses but is currently only approved by the FDA to treat interstitial cystitis.

The story of dimethyl sulfoxide (DMSO) is an unusual one. This by-product of the paper making process was discovered in Germany in the late 19th century. It’s a colorless liquid that gained notoriety for its ability to penetrate the skin and other biological membranes.

Scientists discovered that they could use DMSO as a transportation device to pass small molecules through skin in the 1960s. Since then, scientists have researched the potential benefits and risks of using DMSO to treat a variety of conditions. This research is ongoing.

DMSO was approved by the Food and Drug Administration (FDA)to treat interstitial cystitis (a chronic bladder issue) under the brand name RIMSO-50.

The compound has no other approved uses, but it’s been purported to be a treatment for:

• arthritis
• cancer
• chemotherapy side effects
• general pain

Because it absorbs easily into the skin, it’s also been studied as a vehicle for administering topical drugs.

In the late 70s, the FDA approved DMSO to help treat interstitial cystitis. It remains the only FDA-approved bladder installation (or bladder wash) for this condition. For individuals living with interstitial cystitis, DMSO has been shown to:

• ease pain due to the condition
• help relax the bladder
• increase bladder capacity

When it comes to off-label uses, DMSO is often employed as an alternative treatment to reduce inflammation and pain.

Because it absorbs easily into the skin, DMSO may be a beneficial alternative to other pain medications. However, further investigation into this area is needed before any conclusions can be drawn.

DMSO has also been touted for its ability to reduce the amount of leakage during chemotherapy administration, but more studies, and real-world usage, need to be done before it can be labeled as a trusted method.

Additionally, there has been some research into DMSO’s benefits when it comes to inhibiting cancer cells. A 2020 study published in the Journal of Medical Discovery found evidence of benefit. However, research is just beginning in this area, so many more studies need to be done before any conclusions can be made.

While many of the reported side effects of taking DMSO are mild, the amount of DMSO someone takes is directly correlated to the severity of the reaction.

One common side effect is the taste of garlic in the mouth and throat.

More severe side effects include:

• headache
• nausea
• vomiting
• stomach ache
• diarrhea
• fever
• chills
• a lowered heart rate
• itching
• rash
• rough or thickened skin

Risks

Because it’s seen as a more alternative treatment, DMSO is easy to find and buy online. However, buying this product and using it without a healthcare professional’s supervision could increase the likelihood of overuse.

DMSO may also increase the effect of a few medications, which could produce serious reactions in some people. A few medications DMSO may affect include:

• sedatives
• blood thinners
• steroids

DMSO can be administered

• topically, via a gel or solution
• as a bladder wash, via a catheter (for interstitial cystitis)

As with any alternative treatment, it’s always advised to talk with a doctor before deciding to purchase any product that contains DMSO. Dosage is directly connected to the severity of possible side effects.

Dimethyl sulfoxide (DMSO) is a chemical solvent that is sometimes used to help reduce inflammation and pain, and may also be beneficial in reducing leakage during chemotherapy treatment.

It has been FDA approved to treat only one condition: interstitial cystitis.

Because of possible interactions with other common medications, and lack of definitive research into its benefits, DMSO should not be used without medical supervision.

Last medically reviewed on February 1, 2022

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

• Capriotti K, et al. (2012). Dimethyl sulfoxide: History, chemistry, and clinical
  utility in dermatology.
  ncbi.nlm.nih.gov/pmc/articles/PMC3460663/
• Dimethylsulfoxide. (2020).
  mskcc.org/cancer-care/integrative-medicine/herbs/dimethylsulfoxide
• DMSO. (2009).
  ichelp.org/wp-content/uploads/2015/06/DMSO-Feb-2009.pdf
• Elisia I, et al. (2016). DMSO represses inflammatory cytokine production from human blood cells and reduces autoimmune arthritis.
  ncbi.nlm.nih.gov/pmc/articles/PMC4816398/
• Madsen BK, et al. (2018). Adverse reactions of dimethyl sulfoxide in humans: A systematic review.
  ncbi.nlm.nih.gov/pmc/articles/PMC6707402/
• Molecule of the week archive: Dimethyl sulfoxide. (2021).
  acs.org/content/acs/en/molecule-of-the-week/archive/d/dimethyl-sulfoxide.html?cid=home_motw
• Tang H, et al. (2020). DMSO inhibits growth and induces apoptosis through extrinsic pathway in human cancer cells.
  https://www.proquest.com/openview/06527232a660b6867effa2ff8f68deed/1?pq-origsite=gscholar&cbl=2050635
• Understanding unapproved use of approved drugs “off-label.” (2018).
  fda.gov/patients/learn-about-expanded-access-and-other-treatment-options/understanding-unapproved-use-approved-drugs-label
• Wengström Y, et al. (2008). European oncology nursing society extravasation guidelines.
  sciencedirect.com/science/article/abs/pii/S1462388908001002
• What is interstitial cystitis(IC)/bladder pain syndrome? (n.d.).
  urologyhealth.org/urology-a-z/i/interstitial-cystitis

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Current Version

May 16, 2023

Written By

Jessica DiGiacinto, Joe Bowman

Edited By

Jessica DiGiacinto

Copy Edited By

Delores Smith-Johnson

Feb 1, 2022

Medically Reviewed By

Angelica Balingit, MD

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Medically reviewed by Angelica Balingit, MD — By Jessica DiGiacinto and Joe Bowman — Updated on May 16, 2023

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DMSO – Health Information Library

Uses

DMSO (dimethyl sulfoxide) is a colorless, slightly oily liquid that is primarily used as an industrial solvent.

What Are Star Ratings?

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

3 Stars
Reliable and relatively consistent scientific data showing a substantial health benefit.

2 Stars
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

1 Star
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

This supplement has been used in connection with the following health conditions:

How It Works

How to Use It

DMSO is not indicated for healthy people. Those who do use this substance should consult a doctor familiar with its use. Some physicians do not recommend the use of DMSO due to concerns about safety and questions about efficacy. The potential for contamination exists in some DMSO products designed for industrial uses. DMSO used topically is rapidly absorbed through intact skin. Therefore, the area of skin (and the hands applying DMSO) must be clean, because anything on the skin will also be absorbed along with the DMSO.

Where to Find It

DMSO is derived from trees as a manufacturing by-product from the processing of paper. Metabolites (breakdown products) of DMSO, such as the sulfide and sulfone forms, are naturally present in the human body. However, the role of these in the body is not clear.

Possible Deficiencies

DMSO is not an essential nutrient and it is not needed in the functions of a healthy body; therefore, deficiencies do not exist.

Interactions

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

DMSO frequently causes a garlic-like body odor and taste in the mouth. Other reported side effects include stomach upset, sensitivity to light, visual disturbances, and headache. Skin irritation can develop at the site where DMSO is applied topically. Only highly purified, properly diluted DMSO should be used and the skin site and applying hand should be thoroughly cleaned before application, because the solvent properties of DMSO allow contaminants to be absorbed through the skin and transported into the bloodstream. Improperly diluted DMSO can also burn the skin. Check with a healthcare professional for appropriate use.

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Health Information Library

Teraflex Chondrocream forte cream 50g with free home delivery from VkusVill

VkusVill

Cream from light yellow with a greenish tint to yellow with a greenish tint, with the smell of dimethyl sulfoxide.

Theraflex Chondrocream forte cream 50g / Pharmacy

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Pharmacy//Drugs//Joints

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631 rub/piece 631.00 631.00

from the partner “Pharmacy DIALOG Stolitsa”

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Description

Cream from light yellow with a greenish tint to yellow with a greenish tint, with a smell of dimethyl sulfoxide.

Indications for use

The drug is recommended for use as part of complex therapy for degenerative-dystrophic diseases of the musculoskeletal system: osteoarthritis, osteochondrosis of the spine, and other joint diseases accompanied by pain.

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Nizhpharm

INN/Active ingredient Dosage

10 mg/g + 50 mg/g

Release form Quantity in a package Composition Method of preparation Special conditions Side effects Contraindications Storage conditions Shelf life Minimum age Partner

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What helps, active ingredient, contraindications

Publication date: 06/15/2023

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS NECESSARY Joint painPain in joints and musclesInflammation of jointsFor joints and ligaments 3 All authors

Article content

• Dolobene: composition
• Dolobene: contraindications
• Dolobene or Heparin ointment: which is better?
• Dolobene or Diclofenac: which is better?
• Dolobene or Voltaren: which is better?
• Dolgit or Dolobene: which is better?
• Dolobene or Fastum gel: which is better?
• Dolobene or Traumeel: which is better?
• Summary
• Ask an expert on the topic of the article

I wonder if there is a person on earth who has escaped such an injury as a bruise? We think not…

Bruises are characterized by mechanical damage without breaking the integrity of the skin. They are accompanied by pain, swelling and bruising. All these symptoms occur due to vascular damage and activation of the inflammation process. As a rule, bruises are not dangerous and pass at home in a week. But in case of an injury to the head or internal organs, it is imperative to see a doctor.

At home, Dolobene helps to cope with the consequences of bruises. The pharmacist talks about its composition and contraindications and compares it with other means: Heparin ointment, Diclofenac, Voltaren, Dolgit, Fastum gel and Traumeel.

Dolobene: Composition

Dolobene is a multicomponent gel for external use. The composition of Dolobene includes not one active ingredient, but three:

• Sodium heparin has anti-inflammatory, regenerating and antithrombotic effects.
• Dexpanthenol – in the skin turns into vitamin B5 (pantothenic acid) and improves the processes of regeneration and repair of damaged tissues.
• Dimethyl sulfoxide 90% solution (DMSO) – has a local analgesic, decongestant and anti-inflammatory effect. It penetrates well through the skin, mucous membranes, improves microcirculation in tissues and increases the permeability of biological membranes for drugs.

The assortment of modern pharmacies has taught visitors that the same medicine can be in different dosage forms. But the drug Dolobene gel is available in only one form, you should not look for ointment, cream or tablets in Dolobene pharmacies.

All products Dolobene

5 reviews

Dolobene: contraindications

Dolobene should not be used during pregnancy, as there are no studies on the use of the drug in such patients. In addition, the gel is contraindicated in the following cases:

• hypersensitivity to drug components;
• open skin lesions;
• severe diseases of the liver and kidneys;
• serious diseases of the heart and blood vessels;
• bronchial asthma;
• children under 5 years of age;
• lactation.

Dolobene or Heparin ointment: which is better?

Heparin ointment also contains three active ingredients: sodium heparin, benzocaine, benzyl nicotinate. The common component with Dolobene in the ointment is only Heparin sodium.

Dolobene – what helps? Gel is prescribed for bruises, closed injuries and inflammation of soft tissues, tendons and joints. Dolobene helps with bruises, swelling and pain in acute neuralgia.

Heparin ointment has different indications due to a different composition. The ointment is used for inflammatory diseases of the veins (thrombophlebitis, periphlebitis, phlebitis after injections, hemorrhoids), as well as for superficial mastitis, infiltrates, edema, injuries and bruises.

Dolobene contains 500 IU/g of heparin and Heparin Ointment contains 100 IU/g. According to the instructions in the RLS, the penetration of heparin through healthy skin is dose-dependent and has been confirmed for doses of 300 IU/g. The effectiveness of heparin in Doloben is higher due to the dosage and content of the “conductor” DMSO in the gel composition.

Heparin ointment has its own advantages: it has a pronounced analgesic effect due to the local anesthetic benzocaine. In addition, it can be used for bruises and bruises in children older than 1 year, unlike Dolobene, which is used only after 5 years.

Dolobene or Diclofenac: which is better?

Diclofenac is the “gold standard” of non-steroidal anti-inflammatory drugs (NSAIDs). The active substance of the same name comes in various forms for external use: gel, ointment, cream, transdermal patch. Diclofenac has a strong anti-inflammatory effect, so it is prescribed for diseases of the spine and joints, as well as to relieve pain and inflammation due to sprains, bruises and injuries.

The drugs act differently, for example, Dolobene will not help with osteochondrosis, it has an insufficient anti-inflammatory and analgesic effect. But swelling and hematoma after a bruise will pass with it faster than with Diclofenac ointment or gel.

All products Diclofenac

20 reviews

Dolobene or Voltaren: which is better?

Voltaren is an original drug with the active ingredient diclofenac. The above information about Diclofenac is fully applicable to it: Voltaren topical agents relieve inflammation and pain well, and Dolobene improves microcirculation, relieves swelling, dissolves blood clots and promotes tissue repair.

Voltaren topical preparations can only be used in children from 12 years of age. For pregnant women, they can be prescribed by a doctor only up to the 20th week of pregnancy.

All products Voltaren Emulgel

21 reviews

Dolgit or Dolobene: which is better?

Dolgit contains another non-steroidal anti-inflammatory drug, ibuprofen. Dolgit is available in the form of a gel and cream. The drug is approved for use in children from 14 years of age, pregnant women are prescribed only Dolgit gel in the I and II trimester according to indications and under the supervision of a doctor, the cream is contraindicated throughout pregnancy.

The property of ibuprofen to reduce pain and inflammation is used to treat arthritis, osteoarthritis, sciatica, etc. Like Dolobene, Dolgit relieves pain after injuries and bruises. But it does not affect the restoration of tissues and the improvement of blood circulation in the damaged area.

All products Dolgit

20 reviews

Dolobene or Fastum gel: which is better?

The next representative of NSAIDs for the treatment of pain and inflammation is Fastum gel with the active ingredient ketoprofen. Like Dolobene, it has one dosage form in the form of a gel for external use.

Ketoprofen has the most powerful analgesic effect among NSAIDs, so it is used for severe pain as a result of injuries, including bruises, sprains and muscles, as well as for lumbago and rheumatic pains. The gel is contraindicated in pregnancy in the third trimester and in children under 12 years of age.

Fastum causes photosensitivity. When using it, you should protect the skin from the sun during treatment and for another two weeks after it. With mild or moderate pain, bruising and swelling, it is better to use Dolobene.

All products Fastum gel

20 reviews

Dolobene or Traumeel: which is better?

Traumeel S is a homeopathic remedy. Active substances are 12 vegetable and 2 mineral components. Their combination acts in synergy and has an anti-inflammatory and analgesic effect.

Traumeel S is available as an ointment and is approved for use by adults and children from 3 years of age. The ointment eliminates swelling, pain and inflammation in case of damage to muscles, tendons, ligaments; after operations; with bruises, sprains, dislocations.

The ointment can be used in pregnant women if the expected benefit to the mother outweighs the potential risk to the fetus and child. Contraindications for Traumeel S are autoimmune diseases and tuberculosis.

Traumeel S ointment and Dolobene gel are available without a doctor’s prescription. The patient can consult a pharmacy or his doctor and purchase one of the drugs based on his preferences.

All products Traumeel

20 reviews

Summary

• Dolobene is a multicomponent gel for external use. It contains sodium heparin, dexpanthenol and dimethyl sulfoxide. The gel is prescribed for bruises, closed injuries and inflammation of soft tissues, tendons and joints. Dolobene helps with bruises, swelling and pain in acute neuralgia.
• Dolobene should not be used during pregnancy, as there are no studies on the use of the drug in such patients.
• Heparin ointment also contains three active ingredients: sodium heparin, benzocaine, benzyl nicotinate. The ointment is used for inflammatory diseases of the veins (thrombophlebitis, periphlebitis, phlebitis after injections, hemorrhoids), as well as for superficial mastitis, infiltrates, edema, injuries and bruises.
• Voltaren with Diclofenac, as representatives of NSAIDs, act differently. For example, Dolobene will not help with osteochondrosis, it has an insufficient anti-inflammatory and analgesic effect. But swelling and hematoma after a bruise will pass with it faster than with an ointment or gel with diclofenac.