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DMSO Cream Side Effects: Comprehensive Guide to Dimethyl Sulfoxide Uses and Risks

What are the potential side effects of DMSO cream. How is dimethyl sulfoxide used medically. What conditions can DMSO potentially treat. What precautions should be taken when using DMSO.

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What is DMSO and How Was It Discovered?

Dimethyl sulfoxide (DMSO) is a colorless chemical solvent with a fascinating history dating back to the late 19th century. Originally discovered in Germany as a byproduct of paper manufacturing, DMSO gained scientific interest in the 1960s when researchers uncovered its unique ability to penetrate biological membranes, including human skin. This property allows DMSO to act as a transporter, facilitating the passage of small molecules through the skin barrier.

DMSO’s discovery opened up new possibilities in medical research and drug delivery. Its ability to easily absorb into the skin made it an intriguing candidate for topical drug administration. However, despite decades of research, DMSO’s potential applications remain largely unexplored in mainstream medicine.

Chemical Properties of DMSO

  • Colorless liquid at room temperature
  • Slightly oily texture
  • Distinctive odor often described as garlic-like
  • Highly soluble in both water and organic solvents
  • Freezing point of 18.5°C (65.3°F)

FDA-Approved Uses of DMSO: Interstitial Cystitis Treatment

While DMSO has been studied for various potential applications, it currently has only one FDA-approved use in the United States. In the late 1970s, the Food and Drug Administration granted approval for DMSO to be used in the treatment of interstitial cystitis, a chronic bladder condition characterized by pain and pressure in the bladder area.

For interstitial cystitis patients, DMSO is administered as a bladder installation, also known as a bladder wash. This treatment, marketed under the brand name RIMSO-50, has shown several benefits:

  1. Pain relief associated with the condition
  2. Relaxation of the bladder muscles
  3. Increased bladder capacity

The approval of DMSO for interstitial cystitis treatment marked a significant milestone in the medical use of this compound. However, it’s important to note that this remains its sole FDA-approved application to date.

Potential Off-Label Uses and Ongoing Research

While DMSO is only FDA-approved for treating interstitial cystitis, researchers have been exploring its potential benefits for various other conditions. These off-label uses, while not officially sanctioned, have garnered interest in both scientific and alternative medicine communities.

DMSO for Pain and Inflammation

One of the most commonly cited off-label uses for DMSO is as an alternative treatment for pain and inflammation. Its ability to penetrate the skin quickly makes it an intriguing option for topical pain relief. Some proponents claim it may help with conditions such as:

  • Arthritis
  • General muscle and joint pain
  • Inflammatory conditions

However, it’s crucial to note that while anecdotal evidence exists, more robust clinical studies are needed to definitively establish DMSO’s efficacy and safety for these uses.

DMSO in Cancer Research

Another area of ongoing research involves DMSO’s potential role in cancer treatment. Some studies have explored its use in two main areas:

  1. Reducing chemotherapy-related side effects: Researchers have investigated whether DMSO could help minimize tissue damage caused by chemotherapy drugs leaking during administration.
  2. Potential anti-cancer properties: A 2020 study published in the Journal of Medical Discovery found evidence suggesting DMSO might have inhibitory effects on certain cancer cells.

It’s important to emphasize that research in this area is still in its early stages. While these preliminary findings are intriguing, much more extensive study is required before any conclusions can be drawn about DMSO’s potential role in cancer treatment.

Common Side Effects of DMSO: What to Expect

As with any medical treatment, DMSO can cause side effects. The severity and likelihood of these side effects often correlate with the dosage and method of administration. Understanding these potential reactions is crucial for anyone considering or using DMSO.

Mild Side Effects

The most commonly reported side effect of DMSO use is a distinctive taste and odor, often described as garlic-like. This sensation can affect both the mouth and breath, and it typically occurs shortly after DMSO application or ingestion. While not harmful, some individuals find this effect unpleasant or socially awkward.

More Severe Side Effects

In some cases, particularly with higher doses or prolonged use, DMSO can cause more significant side effects. These may include:

  • Headache
  • Nausea and vomiting
  • Stomach discomfort
  • Diarrhea
  • Fever or chills
  • Changes in heart rate, typically a decrease
  • Skin reactions such as itching, rash, or changes in skin texture

Is there a way to minimize DMSO side effects? While individual reactions can vary, some strategies may help reduce the risk or severity of side effects:

  1. Start with a low dose and gradually increase if needed
  2. Apply DMSO to clean, dry skin to prevent contamination
  3. Avoid using DMSO on broken or irritated skin
  4. Stay well-hydrated when using DMSO
  5. Monitor for any unusual reactions and discontinue use if severe side effects occur

Potential Risks and Interactions: What You Need to Know

While DMSO has shown promise in various applications, it’s crucial to be aware of potential risks and interactions, especially when used without medical supervision. The ease of obtaining DMSO online has led to concerns about its unregulated use.

Drug Interactions

One of the primary concerns with DMSO use is its potential to interact with other medications. DMSO may enhance the effects of certain drugs, which could lead to unexpected or dangerous reactions. Some medications that may interact with DMSO include:

  • Sedatives
  • Blood thinners
  • Steroids

How does DMSO interact with these medications? DMSO’s ability to increase skin permeability can potentially enhance the absorption of other drugs, leading to higher-than-intended doses entering the bloodstream. Additionally, DMSO may affect how the body processes certain medications, altering their effectiveness or side effect profile.

Risks of Unsupervised Use

The accessibility of DMSO products online has raised concerns about potential misuse or overuse. Without proper medical guidance, individuals may be at risk of:

  1. Incorrect dosing
  2. Using contaminated or low-quality products
  3. Applying DMSO for inappropriate conditions
  4. Overlooking potential interactions with existing medications or health conditions

What precautions should be taken when considering DMSO use? It’s essential to consult with a healthcare professional before starting any DMSO regimen. They can provide guidance on appropriate dosing, potential risks, and whether DMSO is suitable for your specific situation.

Administration Methods: How is DMSO Used?

DMSO can be administered through various routes, depending on its intended use and the condition being treated. Understanding these different methods is crucial for safe and effective use.

Topical Application

One of the most common ways to use DMSO is through topical application. This method involves applying DMSO directly to the skin, typically in the form of:

  • Gels
  • Creams
  • Solutions

Topical DMSO is often used for localized pain relief or to aid in the absorption of other medications. When applying DMSO topically, it’s important to use it on clean, dry skin and avoid areas with cuts or irritation.

Bladder Instillation

For the treatment of interstitial cystitis, DMSO is administered directly into the bladder through a catheter. This procedure, known as bladder instillation or bladder wash, is typically performed by a healthcare professional.

How often is DMSO bladder instillation performed? The frequency can vary depending on the individual’s condition and response to treatment. Initially, it may be done weekly for several weeks, followed by maintenance treatments as needed.

Other Potential Routes

While less common and often not approved for general use, DMSO has been studied for administration through other routes, including:

  1. Oral ingestion
  2. Intravenous injection
  3. Intramuscular injection

It’s crucial to note that these methods should only be used under strict medical supervision, if at all, due to potential risks and the lack of FDA approval for most applications.

The Importance of Medical Supervision in DMSO Use

Given the potential risks and uncertainties surrounding DMSO use, medical supervision is crucial for anyone considering this treatment. While DMSO is available over-the-counter in some forms, consulting with a healthcare professional can help ensure safe and appropriate use.

Benefits of Medical Guidance

Seeking medical advice before using DMSO offers several important benefits:

  • Proper dosing: A healthcare provider can recommend the appropriate concentration and frequency of DMSO use based on your specific condition and health status.
  • Monitoring for side effects: Regular check-ups can help detect any adverse reactions early on.
  • Assessing drug interactions: Your doctor can evaluate potential interactions between DMSO and any other medications you’re taking.
  • Ensuring quality: Medical professionals can guide you towards reputable sources of DMSO, reducing the risk of using contaminated or substandard products.

When to Seek Medical Attention

If you’re using DMSO, it’s important to know when to seek immediate medical attention. Contact your healthcare provider if you experience:

  1. Severe skin reactions or rashes
  2. Difficulty breathing
  3. Chest pain or irregular heartbeat
  4. Severe headache or dizziness
  5. Persistent nausea or vomiting

How can you find a healthcare provider knowledgeable about DMSO? Consider reaching out to integrative medicine practitioners or specialists in the condition you’re seeking to treat. They may have more experience with alternative treatments like DMSO.

Future Directions: Ongoing Research and Potential Applications

Despite being discovered over a century ago, DMSO continues to intrigue researchers with its unique properties and potential applications. Ongoing studies are exploring new ways this compound might be used in medicine and beyond.

Emerging Areas of DMSO Research

Several promising areas of DMSO research are currently underway:

  • Neuroprotection: Some studies suggest DMSO might have protective effects on nerve cells, potentially benefiting conditions like stroke or traumatic brain injury.
  • Cryopreservation: DMSO’s ability to prevent ice crystal formation makes it valuable in preserving biological samples and tissues.
  • Drug delivery systems: Researchers are exploring how DMSO’s penetration-enhancing properties could improve the delivery of other medications.
  • Anti-inflammatory effects: Further investigation into DMSO’s potential anti-inflammatory properties could lead to new treatments for various conditions.

Challenges in DMSO Research

Despite its potential, DMSO research faces several challenges:

  1. Regulatory hurdles: The FDA’s current stance on DMSO limits its approved uses, making large-scale clinical trials more difficult to conduct.
  2. Funding issues: As a non-patentable substance, DMSO may attract less investment from pharmaceutical companies.
  3. Standardization concerns: The wide variety of DMSO products and concentrations available can make it challenging to conduct consistent, comparable studies.

What does the future hold for DMSO research? While it’s difficult to predict with certainty, continued scientific interest suggests that new applications and insights may emerge in the coming years. As our understanding of DMSO’s mechanisms and effects grows, so too may its potential role in medical treatment.

In conclusion, DMSO remains a compound of significant interest in both medical research and alternative medicine circles. While its FDA-approved uses are currently limited, ongoing studies continue to explore its potential benefits and risks. As with any medical treatment, it’s crucial to approach DMSO use with caution and under proper medical supervision. The future may hold new discoveries about this intriguing substance, but for now, a balanced understanding of its known effects, both positive and negative, is essential for anyone considering its use.

Uses, Benefits, Risks, and More

DMSO (Dimethyl Sulfoxide): Uses, Benefits, Risks, and More

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Medically reviewed by Angelica Balingit, MD — By Jessica DiGiacinto and Joe Bowman — Updated on May 16, 2023

DMSO is a colorless chemical solvent that may have many medical uses but is currently only approved by the FDA to treat interstitial cystitis.

The story of dimethyl sulfoxide (DMSO) is an unusual one. This by-product of the paper making process was discovered in Germany in the late 19th century. It’s a colorless liquid that gained notoriety for its ability to penetrate the skin and other biological membranes.

Scientists discovered that they could use DMSO as a transportation device to pass small molecules through skin in the 1960s. Since then, scientists have researched the potential benefits and risks of using DMSO to treat a variety of conditions. This research is ongoing.

DMSO was approved by the Food and Drug Administration (FDA)to treat interstitial cystitis (a chronic bladder issue) under the brand name RIMSO-50.

The compound has no other approved uses, but it’s been purported to be a treatment for:

  • arthritis
  • cancer
  • chemotherapy side effects
  • general pain

Because it absorbs easily into the skin, it’s also been studied as a vehicle for administering topical drugs.

In the late 70s, the FDA approved DMSO to help treat interstitial cystitis. It remains the only FDA-approved bladder installation (or bladder wash) for this condition. For individuals living with interstitial cystitis, DMSO has been shown to:

  • ease pain due to the condition
  • help relax the bladder
  • increase bladder capacity

When it comes to off-label uses, DMSO is often employed as an alternative treatment to reduce inflammation and pain.

Because it absorbs easily into the skin, DMSO may be a beneficial alternative to other pain medications. However, further investigation into this area is needed before any conclusions can be drawn.

DMSO has also been touted for its ability to reduce the amount of leakage during chemotherapy administration, but more studies, and real-world usage, need to be done before it can be labeled as a trusted method.

Additionally, there has been some research into DMSO’s benefits when it comes to inhibiting cancer cells. A 2020 study published in the Journal of Medical Discovery found evidence of benefit. However, research is just beginning in this area, so many more studies need to be done before any conclusions can be made.

While many of the reported side effects of taking DMSO are mild, the amount of DMSO someone takes is directly correlated to the severity of the reaction.

One common side effect is the taste of garlic in the mouth and throat.

More severe side effects include:

  • headache
  • nausea
  • vomiting
  • stomach ache
  • diarrhea
  • fever
  • chills
  • a lowered heart rate
  • itching
  • rash
  • rough or thickened skin

Risks

Because it’s seen as a more alternative treatment, DMSO is easy to find and buy online. However, buying this product and using it without a healthcare professional’s supervision could increase the likelihood of overuse.

DMSO may also increase the effect of a few medications, which could produce serious reactions in some people. A few medications DMSO may affect include:

  • sedatives
  • blood thinners
  • steroids

DMSO can be administered

  • topically, via a gel or solution
  • as a bladder wash, via a catheter (for interstitial cystitis)

As with any alternative treatment, it’s always advised to talk with a doctor before deciding to purchase any product that contains DMSO. Dosage is directly connected to the severity of possible side effects.

Dimethyl sulfoxide (DMSO) is a chemical solvent that is sometimes used to help reduce inflammation and pain, and may also be beneficial in reducing leakage during chemotherapy treatment.

It has been FDA approved to treat only one condition: interstitial cystitis.

Because of possible interactions with other common medications, and lack of definitive research into its benefits, DMSO should not be used without medical supervision.

Last medically reviewed on February 1, 2022

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  • Capriotti K, et al. (2012). Dimethyl sulfoxide: History, chemistry, and clinical
    utility in dermatology.
    ncbi.nlm.nih.gov/pmc/articles/PMC3460663/
  • Dimethylsulfoxide. (2020).
    mskcc.org/cancer-care/integrative-medicine/herbs/dimethylsulfoxide
  • DMSO. (2009).
    ichelp.org/wp-content/uploads/2015/06/DMSO-Feb-2009.pdf
  • Elisia I, et al. (2016). DMSO represses inflammatory cytokine production from human blood cells and reduces autoimmune arthritis.
    ncbi.nlm.nih.gov/pmc/articles/PMC4816398/
  • Madsen BK, et al. (2018). Adverse reactions of dimethyl sulfoxide in humans: A systematic review.
    ncbi.nlm.nih.gov/pmc/articles/PMC6707402/
  • Molecule of the week archive: Dimethyl sulfoxide. (2021).
    acs.org/content/acs/en/molecule-of-the-week/archive/d/dimethyl-sulfoxide.html?cid=home_motw
  • Tang H, et al. (2020). DMSO inhibits growth and induces apoptosis through extrinsic pathway in human cancer cells.
    https://www.proquest.com/openview/06527232a660b6867effa2ff8f68deed/1?pq-origsite=gscholar&cbl=2050635
  • Understanding unapproved use of approved drugs “off-label.” (2018).
    fda.gov/patients/learn-about-expanded-access-and-other-treatment-options/understanding-unapproved-use-approved-drugs-label
  • Wengström Y, et al. (2008). European oncology nursing society extravasation guidelines.
    sciencedirect.com/science/article/abs/pii/S1462388908001002
  • What is interstitial cystitis(IC)/bladder pain syndrome? (n.d.).
    urologyhealth.org/urology-a-z/i/interstitial-cystitis

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Current Version

May 16, 2023

Written By

Jessica DiGiacinto, Joe Bowman

Edited By

Jessica DiGiacinto

Copy Edited By

Delores Smith-Johnson

Feb 1, 2022

Medically Reviewed By

Angelica Balingit, MD

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Medically reviewed by Angelica Balingit, MD — By Jessica DiGiacinto and Joe Bowman — Updated on May 16, 2023

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DMSO – Health Information Library

Uses

DMSO (dimethyl sulfoxide) is a colorless, slightly oily liquid that is primarily used as an industrial solvent.

What Are Star Ratings?

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

3 Stars
Reliable and relatively consistent scientific data showing a substantial health benefit.

2 Stars
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

1 Star
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

This supplement has been used in connection with the following health conditions:

Used forWhy

3 Stars

Tendinitis

Apply a 10% gel twice per day under medical supervision

Dimethyl sulfoxide is anti-inflammatory and may be applied topically to reduce pain and swelling.

, or dimethyl sulfoxide, has a long history as a topical anti-inflammatory agent. One double-blind trial used a 10% DMSO gel topically on patients with tendinitis of the elbow and shoulder and found that it significantly reduced pain and inflammation in each joint. Other preliminary and double-blind trials found DMSO to be effective in treating tendinitis, but one double-blind trial found no difference between the effects of a 70% DMSO solution and a 5% DMSO placebo solution. Certain precautions must be taken when applying DMSO, and it should only be used under the guidance of a qualified healthcare professional.

2 Stars

Osteoarthritis

Apply a gel containing 25% DMSO under the direction of a qualified healthcare practitioner

Topical DMSO appears to be anti-inflammatory and able to relieve pain associated with osteoarthritis, possibly by inhibiting the transmission of pain messages by nerves.

The therapeutic use of (dimethyl sulfoxide) is controversial because of safety concerns, but some preliminary research shows that diluted preparations of DMSO, applied directly to the skin, are anti-inflammatory and alleviate pain, including pain associated with osteoarthritis. A recent double-blind trial found that a 25% concentration of DMSO in gel form relieved osteoarthritis pain significantly better than a placebo after three weeks. DMSO appears to reduce pain by inhibiting the transmission of pain messages by nerves rather than through a process of healing damaged joints. DMSO comes in different strengths and different degrees of purity; in addition, certain precautions must be taken when applying DMSO. For these reasons, DMSO should be used only with the supervision of a doctor.

2 Stars

Rheumatoid Arthritis

Consult a qualified healthcare practitioner

When applied to the skin, DMSO has anti-inflammatory properties and alleviates pain, apparently by inhibiting the transmission of pain messages by nerves.

The use of dimethyl sulfoxide () for therapeutic applications is controversial in part because some claims made by advocates appear to extend beyond current scientific evidence, and in part because topical use greatly increases the absorption of any substance that happens to be on the skin, including molecules that are toxic to the body. Nonetheless, there is some preliminary evidence that when applied to the skin, it has anti-inflammatory properties and alleviates pain, such as that associated with RA. DMSO appears to reduce pain by inhibiting the transmission of pain messages by nerves. It comes in different strengths and degrees of purity, and certain precautions must be taken when applying DMSO. For these reasons, DMSO should be used only under the supervision of a doctor.

1 Star

Dupuytren’s Contracture

Refer to label instructions

Supplemental dimethyl sulfoxide applied to the affected area may reduce pain by inhibiting transmission of pain messages, and may also soften the connective tissue.

applied to the affected area may reduce pain by inhibiting transmission of pain messages, and may also soften the abnormal connective tissue associated with disorders such as Dupuytren’s contracture, keloids, Peyronie’s disease, and scleroderma. Research on the use of topical DMSO to treat Dupuytren’s contracture remains preliminary and unproven.

1 Star

Peptic Ulcer

Refer to label instructions

DMSO is believed to have antioxidant activity and was found in one study to reduce relapse rates better than the ulcer drug cimetidine (Tagamet).

Oral supplementation with dimethyl sulfoxide () reduced relapse rates for peptic ulcer significantly better than did placebo or the ulcer drug cimetidine (Tagamet) in one study. Previous research showed that DMSO in combination with cimetidine was more effective than cimetidine alone. These trials used 500 mg of DMSO taken four times per day. The authors of these trials believe the antioxidant activity of DMSO may have a protective effect. Oral supplementation with DMSO should not be attempted without the supervision of a doctor.

1 Star

Reflex Sympathetic Dystrophy

Refer to label instructions

1 Star

Scleroderma

Refer to label instructions

1 Star

Sprains and Strains

Refer to label instructions

DMSO has anti-inflammatory properties and may inhibit the transmission of pain messages by nerves. Supplementing with it may ease the pain of minor injuries.

The use of , a colorless, oily liquid primarily used as an industrial solvent, for therapeutic applications is controversial. However, some evidence indicates that dilutions, when applied directly to the skin, have anti-inflammatory properties and inhibit the transmission of pain messages by nerves, and in this way might ease the pain of minor injuries such as sprains and strains. However no controlled research exists to confirm these effects in sprains and strains. DMSO comes in different strengths and different degrees of purity. In addition, certain precautions must be taken when applying DMSO. For those reasons, DMSO should be used only with the supervision of a doctor.

How It Works

How to Use It

DMSO is not indicated for healthy people. Those who do use this substance should consult a doctor familiar with its use. Some physicians do not recommend the use of DMSO due to concerns about safety and questions about efficacy. The potential for contamination exists in some DMSO products designed for industrial uses. DMSO used topically is rapidly absorbed through intact skin. Therefore, the area of skin (and the hands applying DMSO) must be clean, because anything on the skin will also be absorbed along with the DMSO.

Where to Find It

DMSO is derived from trees as a manufacturing by-product from the processing of paper. Metabolites (breakdown products) of DMSO, such as the sulfide and sulfone forms, are naturally present in the human body. However, the role of these in the body is not clear.

Possible Deficiencies

DMSO is not an essential nutrient and it is not needed in the functions of a healthy body; therefore, deficiencies do not exist.

Interactions

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

DMSO frequently causes a garlic-like body odor and taste in the mouth. Other reported side effects include stomach upset, sensitivity to light, visual disturbances, and headache. Skin irritation can develop at the site where DMSO is applied topically. Only highly purified, properly diluted DMSO should be used and the skin site and applying hand should be thoroughly cleaned before application, because the solvent properties of DMSO allow contaminants to be absorbed through the skin and transported into the bloodstream. Improperly diluted DMSO can also burn the skin. Check with a healthcare professional for appropriate use.

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What helps, active substance, contraindications

Publication date: 06/15/2023

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS NECESSARY.Pain in the jointsPain in the joints and musclesInflammation of the jointsFor joints and ligaments

3 All authors

Article content

  • Dolobene: composition
  • Dolobene: contraindications
  • Dolobene or Heparin ointment: which is better?
  • Dolobene or Diclofenac: which is better?
  • Dolobene or Voltaren: which is better?
  • Dolgit or Dolobene: which is better?
  • Dolobene or Fastum gel: which is better?
  • Dolobene or Traumeel: which is better?
  • Summary
  • Ask an expert on the topic of the article

I wonder if there is a person on earth who has escaped such an injury as a bruise? We think not. ..

Bruises are characterized by mechanical damage without breaking the integrity of the skin. They are accompanied by pain, swelling and bruising. All these symptoms occur due to vascular damage and activation of the inflammation process. As a rule, bruises are not dangerous and pass at home in a week. But in case of an injury to the head or internal organs, it is imperative to see a doctor.

At home, Dolobene helps to cope with the consequences of bruises. The pharmacist talks about its composition and contraindications and compares it with other means: Heparin ointment, Diclofenac, Voltaren, Dolgit, Fastum gel and Traumeel.

Dolobene: Composition

Dolobene is a multicomponent gel for external use. The composition of Dolobene includes not one active ingredient, but three:

  • Sodium heparin has anti-inflammatory, regenerating and antithrombotic effects.
  • Dexpanthenol – in the skin turns into vitamin B5 (pantothenic acid) and improves the processes of regeneration and repair of damaged tissues.
  • Dimethyl sulfoxide 90% solution (DMSO) – has a local analgesic, decongestant and anti-inflammatory effect. It penetrates well through the skin, mucous membranes, improves microcirculation in tissues and increases the permeability of biological membranes for drugs.

The assortment of modern pharmacies has taught visitors that the same medicine can be in different dosage forms. But the drug Dolobene gel is available in only one form, you should not look for ointment, cream or tablets in Dolobene pharmacies.

All products Dolobene

5 reviews

Dolobene: contraindications

Dolobene should not be used during pregnancy, as there are no studies on the use of the drug in such patients. In addition, the gel is contraindicated in the following cases:

  • hypersensitivity to drug components;
  • open skin lesions;
  • severe diseases of the liver and kidneys;
  • serious diseases of the heart and blood vessels;
  • bronchial asthma;
  • children under 5 years of age;
  • lactation.

Dolobene or Heparin ointment: which is better?

Heparin ointment also contains three active ingredients: sodium heparin, benzocaine, benzyl nicotinate. The common component with Dolobene in the ointment is only Heparin sodium.

Dolobene – what helps? Gel is prescribed for bruises, closed injuries and inflammation of soft tissues, tendons and joints. Dolobene helps with bruises, swelling and pain in acute neuralgia.

Heparin ointment has different indications due to a different composition. The ointment is used for inflammatory diseases of the veins (thrombophlebitis, periphlebitis, phlebitis after injections, hemorrhoids), as well as for superficial mastitis, infiltrates, edema, injuries and bruises.

Dolobene contains 500 IU/g of heparin and Heparin Ointment contains 100 IU/g. According to the instructions in the RLS, the penetration of heparin through healthy skin is dose-dependent and has been confirmed for doses of 300 IU/g. The effectiveness of heparin in Doloben is higher due to the dosage and content of the “conductor” DMSO in the gel composition.

Heparin ointment has its own advantages: it has a pronounced analgesic effect due to the local anesthetic benzocaine. In addition, it can be used for bruises and bruises in children older than 1 year, unlike Dolobene, which is used only after 5 years.

Dolobene or Diclofenac: which is better?

Diclofenac is the “gold standard” of non-steroidal anti-inflammatory drugs (NSAIDs). The active substance of the same name comes in various forms for external use: gel, ointment, cream, transdermal patch. Diclofenac has a strong anti-inflammatory effect, so it is prescribed for diseases of the spine and joints, as well as to relieve pain and inflammation due to sprains, bruises and injuries.

The drugs act differently, for example, Dolobene will not help with osteochondrosis, it has an insufficient anti-inflammatory and analgesic effect. But swelling and hematoma after a bruise will pass with it faster than with Diclofenac ointment or gel.

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Dolobene or Voltaren: which is better?

Voltaren is an original drug with the active ingredient diclofenac. The above information about Diclofenac is fully applicable to it: Voltaren topical agents relieve inflammation and pain well, and Dolobene improves microcirculation, relieves swelling, dissolves blood clots and promotes tissue repair.

Voltaren topical preparations can only be used in children from 12 years of age. For pregnant women, they can be prescribed by a doctor only up to the 20th week of pregnancy.

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Dolgit or Dolobene: which is better?

Dolgit contains another non-steroidal anti-inflammatory drug, ibuprofen. Dolgit is available in the form of a gel and cream. The drug is approved for use in children from 14 years of age, pregnant women are prescribed only Dolgit gel in the I and II trimester according to indications and under the supervision of a doctor, the cream is contraindicated throughout pregnancy.

The property of ibuprofen to reduce pain and inflammation is used to treat arthritis, osteoarthritis, sciatica, etc. Like Dolobene, Dolgit relieves pain after injuries and bruises. But it does not affect the restoration of tissues and the improvement of blood circulation in the damaged area.

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Dolobene or Fastum gel: which is better?

The next representative of NSAIDs for the treatment of pain and inflammation is Fastum gel with the active ingredient ketoprofen. Like Dolobene, it has one dosage form in the form of a gel for external use.

Ketoprofen has the most powerful analgesic effect among NSAIDs, so it is used for severe pain as a result of injuries, including bruises, sprains and muscles, as well as for lumbago and rheumatic pains. The gel is contraindicated in pregnancy in the third trimester and in children under 12 years of age.

Fastum causes photosensitivity. When using it, you should protect the skin from the sun during treatment and for another two weeks after it. With mild or moderate pain, bruising and swelling, it is better to use Dolobene.

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Dolobene or Traumeel: which is better?

Traumeel S is a homeopathic remedy. Active substances are 12 vegetable and 2 mineral components. Their combination acts in synergy and has an anti-inflammatory and analgesic effect.

Traumeel S is available as an ointment and is approved for use by adults and children from 3 years of age. The ointment eliminates swelling, pain and inflammation in case of damage to muscles, tendons, ligaments; after operations; with bruises, sprains, dislocations.

The ointment can be used in pregnant women if the expected benefit to the mother outweighs the potential risk to the fetus and child. Contraindications for Traumeel S are autoimmune diseases and tuberculosis.

Traumeel S ointment and Dolobene gel are available without a doctor’s prescription. The patient can consult a pharmacy or his doctor and purchase one of the drugs based on his preferences.

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Summary

  • Dolobene is a multicomponent gel for external use. It contains sodium heparin, dexpanthenol and dimethyl sulfoxide. The gel is prescribed for bruises, closed injuries and inflammation of soft tissues, tendons and joints. Dolobene helps with bruises, swelling and pain in acute neuralgia.
  • Dolobene should not be used during pregnancy, as there are no studies on the use of the drug in such patients.
  • Heparin ointment also contains three active ingredients: sodium heparin, benzocaine, benzyl nicotinate. The ointment is used for inflammatory diseases of the veins (thrombophlebitis, periphlebitis, phlebitis after injections, hemorrhoids), as well as for superficial mastitis, infiltrates, edema, injuries and bruises.
  • Voltaren with Diclofenac, as representatives of NSAIDs, act differently. For example, Dolobene will not help with osteochondrosis, it has an insufficient anti-inflammatory and analgesic effect. But swelling and hematoma after a bruise will pass with it faster than with an ointment or gel with diclofenac.
  • Dolgit relieves pain after injuries and bruises. But it does not affect the restoration of tissues and the improvement of blood circulation in the damaged area.
  • Ketoprofen has the most powerful analgesic effect among NSAIDs, so it is used for severe pain as a result of trauma, including bruises, sprains and muscles, as well as for lumbago and rheumatic pains.
  • Traumeel S is a homeopathic remedy. The ointment eliminates swelling, pain and inflammation in case of damage to muscles, tendons, ligaments; after operations; with bruises, sprains, dislocations. The patient can consult a pharmacy or his doctor and purchase one of the drugs based on his preferences.

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Ripatti Yuliya Igorevna,

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Theraflex Chondrocream forte cream 50g with free home delivery from VkusVill

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wadded shade color with the smell of dimethyl sulfoxide.

Theraflex Chondrocream forte cream 50g / Pharmacy

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from the partner “Apteka Dialog Sever”

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Description

Cream from light yellow with a greenish tint to yellow with a greenish tint, with a smell of dimethyl sulfoxide.

Indications for use

The drug is recommended for use as part of complex therapy for degenerative-dystrophic diseases of the musculoskeletal system: osteoarthritis, osteochondrosis of the spine, and other joint diseases accompanied by pain.