What are the potential benefits and risks of using DMSO. How does DMSO work in the human body. What conditions can DMSO potentially treat. What are the most common side effects of DMSO use. Is DMSO safe for topical and oral use. What precautions should be taken when using DMSO.

Understanding DMSO: Origins and Applications

Dimethyl sulfoxide (DMSO) is a byproduct of paper manufacturing derived from wood. Its history as an industrial solvent dates back to the mid-1800s. In the mid-20th century, researchers began exploring its potential as an anti-inflammatory agent. Today, DMSO has found its way into both medical and alternative health practices.

The U.S. Food and Drug Administration (FDA) has approved DMSO as a prescription medication for treating symptoms of painful bladder syndrome. Under medical supervision, it’s also used to address several other conditions, including shingles. One of DMSO’s unique properties is its ability to penetrate the skin easily, which has led to its use as a vehicle for enhancing the absorption of other medications.

Availability and Forms of DMSO

• Prescription medication for bladder syndrome
• Over-the-counter gels and creams
• Oral supplements (safety unclear)

DMSO is readily available without a prescription, most commonly in gel or cream form. It can be purchased in health food stores, through mail order, and online. While oral supplements exist, their safety profile remains uncertain. The primary method of DMSO application is topical, directly on the skin.

Potential Uses of DMSO in Human Health

Proponents of DMSO have suggested its use for a wide range of conditions. However, it’s crucial to note that scientific evidence supporting many of these claims is limited. Some of the conditions for which people have used DMSO include:

• Osteoarthritis pain relief
• Headache treatment
• Rheumatoid arthritis management
• Eye problems
• Scar treatment
• Scleroderma (a disease causing scar tissue formation in the skin)
• Wound and burn healing

Can DMSO effectively treat cancer? The American Cancer Society states there is no evidence to support the use of DMSO as a cancer treatment. Relying on DMSO for cancer therapy could lead to dangerous delays in receiving proper and effective treatment.

DMSO for Osteoarthritis Pain

Is DMSO effective for osteoarthritis pain relief? A recent analysis of studies on DMSO use for osteoarthritis pain found that it was not significantly more effective than a placebo in alleviating joint pain. This highlights the need for more robust scientific research to validate the efficacy of DMSO for various health conditions.

DMSO Dosage and Administration

There is a lack of comprehensive studies providing guidelines for determining the proper dose of DMSO. For osteoarthritis treatment, a typical concentration of 25% in gel form is applied three to four times daily. However, DMSO products sold without a prescription can vary widely in concentration, ranging from 10% to 90%.

Are all DMSO products of the same quality? It’s important to note that some DMSO available on the market may be industrial grade. These products can contain impurities that are easily absorbed through the skin, potentially leading to serious health effects.

Side Effects and Risks Associated with DMSO Use

While DMSO has potential benefits, it’s not without risks. Users should be aware of both common and serious side effects that may occur with its use.

Common Side Effects of Topical DMSO Application

• Stomach upset
• Skin irritation
• Strong garlic-like odor

Serious Side Effects of DMSO Use

• Severe allergic reactions
• Headaches
• Itching and burning at the application site

In high concentrations, DMSO can potentially cause deadly reactions. This underscores the importance of using DMSO only under medical supervision and at appropriate concentrations.

Side Effects of Oral DMSO Use

When taken orally, DMSO can cause various gastrointestinal and neurological symptoms:

• Dizziness
• Drowsiness
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Decreased appetite

DMSO Interactions with Other Medications

One of the primary concerns with DMSO use is its potential to interact with other medications. DMSO can enhance the effects of certain drugs, which may lead to serious health issues. Some medications that may interact with DMSO include:

• Blood thinners
• Steroids
• Sedatives

Why is DMSO’s ability to enhance absorption a concern? DMSO’s property as a solvent means it can cause anything on the skin to be absorbed more readily. This characteristic necessitates thorough hand and skin washing before DMSO application to prevent unintended absorption of other substances.

Precautions and Contraindications for DMSO Use

Certain groups of people should exercise caution or avoid DMSO use altogether. These include:

• Pregnant women
• Breastfeeding mothers
• Individuals with diabetes
• People with asthma
• Those with liver and kidney conditions

Why should pregnant and breastfeeding women avoid DMSO? Little is known about the potential effects of DMSO on fetuses or infants, making it a risk not worth taking for these groups.

DMSO and FDA Regulation

It’s crucial to remember that dietary supplements, including DMSO, are not regulated by the FDA in the same way as prescription drugs. Manufacturers are not required to prove a supplement’s safety or efficacy before selling it. This lack of regulation underscores the importance of consulting with a healthcare professional before using DMSO for any purpose.

DMSO vs. MSM: Understanding the Difference

Is DMSO the same as Methylsulfonylmethane (MSM)? No, these are two distinct substances. While both contain sulfur and are sometimes used for similar purposes, they have different chemical structures and properties. It’s important not to confuse or substitute one for the other.

FDA-Approved Uses of DMSO

While DMSO is often used for various off-label purposes, it’s important to note its FDA-approved applications. The primary FDA-approved use of DMSO is for the treatment of painful bladder syndrome, also known as interstitial cystitis.

DMSO for Interstitial Cystitis

How does DMSO help with interstitial cystitis? When used to wash the bladder, DMSO has been shown to improve symptoms such as pain associated with this condition. This application is supported by clinical evidence and has received FDA approval.

Other Potentially Effective Uses

Beyond its approved use, DMSO has shown promise in treating other conditions:

• Complex regional pain syndrome: Applying DMSO cream to the skin may improve pain in people with this condition.
• Extravasation: DMSO may be beneficial in cases where intravenous (IV) drugs leak from the vein into surrounding skin and tissue.

These applications, while showing potential, require further research to fully establish their efficacy and safety profiles.

The Science Behind DMSO: How It Works in the Body

Understanding how DMSO functions in the human body is crucial for appreciating both its potential benefits and risks. DMSO has several unique properties that contribute to its effects:

Absorption and Penetration

One of DMSO’s most notable characteristics is its ability to penetrate biological membranes rapidly. This property allows it to be absorbed quickly through the skin and into the bloodstream. How does this affect its use? This rapid absorption means that DMSO can:

• Deliver other medications more effectively when used as a vehicle
• Potentially carry harmful substances into the body if the skin is not clean
• Act quickly when applied topically

Anti-Inflammatory Properties

DMSO has been observed to have anti-inflammatory effects. What mechanisms contribute to this? Several factors may be involved:

• Inhibition of prostaglandin production
• Reduction of free radical damage
• Stabilization of cell membranes

These properties may explain why DMSO has been explored for conditions involving inflammation, such as arthritis.

Analgesic Effects

DMSO’s pain-relieving properties have been a subject of interest. How does DMSO potentially alleviate pain? It may work through multiple mechanisms:

• Blocking pain fibers
• Reducing inflammation
• Improving blood flow to affected areas

These effects could contribute to its use in conditions like complex regional pain syndrome.

Interaction with Body Tissues

DMSO can affect various tissues and substances in the body, including:

• Proteins
• Carbohydrates
• Lipids
• Water

This broad interaction profile may explain its wide range of reported effects and potential uses.

Potential Applications of DMSO in Medicine

While many uses of DMSO remain controversial or unproven, ongoing research continues to explore its potential in various medical fields. Some areas of interest include:

Neuroprotection

Can DMSO protect nerve cells? Some studies suggest that DMSO may have neuroprotective properties, potentially beneficial in conditions involving nerve damage or degeneration. However, more research is needed to confirm these effects and determine safe and effective protocols.

Cryopreservation

DMSO’s ability to penetrate cells and interact with water molecules has made it valuable in cryopreservation techniques. How is DMSO used in this field? It’s often used as a cryoprotectant to prevent ice crystal formation during the freezing of cells and tissues, which is crucial in fields like:

• Stem cell research
• Organ transplantation
• Reproductive medicine

Drug Delivery Systems

The ability of DMSO to enhance the absorption of other substances has led to research into its potential as a drug delivery system. How might this be applied? DMSO could potentially:

• Improve the efficacy of topical medications
• Enhance the delivery of drugs across the blood-brain barrier
• Facilitate the absorption of large molecule drugs

However, this same property also raises concerns about unintended absorption of harmful substances.

Challenges in DMSO Research and Use

Despite its potential, DMSO faces several challenges in both research and clinical application:

Lack of Standardization

The wide range of DMSO concentrations available and the lack of standardized dosing guidelines make it difficult to compare studies and establish clear protocols for use. How does this affect DMSO research? It can lead to:

• Inconsistent results across studies
• Difficulty in determining optimal dosages
• Challenges in assessing safety profiles

Quality Control Issues

The availability of industrial-grade DMSO and the lack of regulation in dietary supplements raise concerns about product quality and safety. What risks does this pose? Users may be exposed to:

• Impurities that could cause adverse effects
• Inconsistent concentrations leading to unpredictable effects
• Potentially harmful additives in unregulated products

Limited Clinical Trials

Many of the proposed uses for DMSO lack robust clinical evidence. Why is this problematic? It leads to:

• Uncertainty about efficacy for many conditions
• Difficulty in establishing clear risk-benefit profiles
• Challenges in gaining regulatory approval for new uses

The Future of DMSO in Medicine and Research

Despite the challenges, DMSO continues to be a subject of interest in both medical research and alternative health practices. What might the future hold for DMSO?

Ongoing Research

Continued scientific investigation may:

• Uncover new potential applications
• Provide clearer evidence for or against current uses
• Lead to improved formulations and delivery methods

Regulatory Developments

As more research emerges, we may see:

• Changes in regulatory status for certain applications
• Improved guidelines for safe use
• Stricter quality control measures for DMSO products

Integration with Conventional Medicine

If supported by strong evidence, DMSO might:

• Find wider acceptance in conventional medical practice
• Be incorporated into new treatment protocols
• Lead to the development of novel DMSO-based therapies

Conclusion: Balancing Potential and Precaution with DMSO

Dimethyl sulfoxide (DMSO) remains a compound of significant interest and controversy in the medical and alternative health communities. Its unique properties offer potential benefits across a range of applications, from pain management to drug delivery. However, the lack of comprehensive research, standardization issues, and potential side effects necessitate a cautious approach to its use.

For individuals considering DMSO use, it’s crucial to:

• Consult with a healthcare professional before starting any DMSO regimen
• Be aware of potential side effects and interactions
• Use only high-quality, pharmaceutical-grade DMSO products
• Follow proper application procedures to minimize risks
• Stay informed about the latest research and regulatory updates

As research continues, our understanding of DMSO’s benefits and risks will likely evolve. Until then, a balanced approach that recognizes both its potential and its limitations is essential. The future of DMSO in medicine and health practices will depend on ongoing scientific investigation, regulatory oversight, and responsible use by both healthcare providers and consumers.

DMSO: Uses and Risks

Written by Joseph Saling

• Why Do People Use DMSO?
• What Are the Risks of Using DMSO?

DMSO, or dimethyl sulfoxide, is a by-product of paper making. It comes from a substance found in wood.

DMSO has been used as an industrial solvent since the mid-1800s. From about the mid-20th century, researchers have explored its use as an anti-inflammatory agent.

The FDA has approved DMSO as a prescription medication for treating symptoms of painful bladder syndrome. It’s also used under medical supervision to treat several other conditions, including shingles.

DMSO is easily absorbed by the skin. It’s sometimes used to increase the body’s absorption of other medications.

DMSO is available without a prescription most often in gel or cream form. It can be purchased in health food stores, by mail order, and on the Internet.

While it can sometimes be found as an oral supplement, its safety is unclear. DMSO is primarily used by applying it to the skin.

DMSO has been used to try to relieve the pain of osteoarthritis. It has also been promoted as an “alternative” cancer treatment.

People have used it to try to treat wounds, burns, and other injuries. People have also used it to try to treat such conditions as:

• Headache
• Rheumatoid arthritis
• Eye problems
• Scars
• Scleroderma (disease that causes scar tissue to form in the skin)

Other than its use as a prescription medicine, there is little or no scientific evidence to support other claims made about DMSO’s effectiveness.

The American Cancer Society says there is no evidence to support the use of DMSO to treat cancer. Using it that way could cause serious delays in getting proper and effective treatment.

A recent analysis of studies on the use of DMSO to relieve osteoarthritis pain found that it was not significantly more effective than placebo in relieving joint pain.

There are no studies that provide guidelines for determining the proper dose of DMSO. The gel used to treat osteoarthritis typically has a concentration of 25%. It is applied three or four times a day. But DMSO sold without a prescription can range from 10% concentration to 90%.

Some DMSO on the market may actually be industrial grade. Industrial grade DMSO may contain a number of impurities that can easily be absorbed into the skin with potentially serious health effects.

The most frequent side effects from using DMSO on the skin include:

• Stomach upset
• Skin irritation
• Strong odor of garlic

More serious side effects include:

• Severe allergic reactions
• Headaches
• Itching and burning when applied to the skin

DMSO can also cause a deadly reaction when used in high concentrations.

Using DMSO by mouth can cause:

• Dizziness
• Drowsiness
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Decreased appetite

DMSO can increase the effect of some medicines, which can lead to serious health issues. Examples of such medicines include:

• Blood thinners
• Steroids
• Sedatives

The biggest concern of DMSO as a solvent is that when it gets on the skin it will cause anything on the skin to be absorbed. So be sure to wash your hands and skin well before using.

Pregnant women and women who are breastfeeding should not use DMSO, since little is known about its possible effects on the fetus or infant.

You should also not use DMSO without talking to your doctor if you have:

• Diabetes
• Asthma
• Liver and kidney conditions

Always keep in mind that supplements are not regulated by the FDA the same was as drugs are. The manufacturer does not have to prove that a supplement is safe or effective before selling.

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Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Dimethylsulfoxide (DMSO) is a chemical that dissolves many organic and inorganic substances. It’s available as a prescription drug and dietary supplement.

DMSO helps medicines get through the skin and can affect proteins, carbohydrates, fats, and water in the body.

People use DMSO for bladderinflammation (interstitial cystitis), limb pain that usually occurs after an injury, and leakage of an IV drug from the vein into surrounding skin and tissue. It is also used for osteoarthritis, bed sores, stomach ulcers, and many other conditions, but there is no good scientific evidence to support most of these other uses.

Don’t confuse DMSO with Methylsulfonylmethane (MSM). These are not the same.

Uses & Effectiveness ?

Effective for

• Painful bladder syndrome (interstitial cystitis). DMSO is an FDA-approved product for the treatment of this condition. Washing the bladder with DMSO improves some symptoms, such as pain.

Possibly Effective for

• Limb pain that usually occurs after an injury (complex regional pain syndrome). Applying DMSO cream to the skin seems to improve pain in people with this condition.
• Leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation). Some chemotherapy drugs can cause skin and tissue damage if they leak from the vein. Applying DMSO to the skin might prevent further damage if this happens.

Possibly Ineffective for

• Hardening of skin and connective tissue (scleroderma). Applying DMSO to the skin doesn’t help treat symptoms of scleroderma.

There is interest in using DMSO for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Special Precautions and Warnings

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Pregnancy and breast-feeding: There isn’t enough reliable information to know if DMSO is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Certain blood disorders. Injecting DMSO by IV might cause red blood cells to break down. This might be a problem for people with certain blood disorders. DMSO might make these conditions worse.

Kidney problems: DMSO might harm the kidneys. Check with a healthcare provider before using DMSO if you have kidney problems.

Liver problems: DMSO might harm the liver. Check with a healthcare provider before using DMSO if you have liver problems.br/>

Interactions ?

Moderate Interaction

Be cautious with this combination

• DMSO can sometimes increase how much medicine the body absorbs. Applying DMSO to the skin, eyes, or ears at the same time as applying medication can increase how much medicine the body absorbs. This might increase the effects and side effects of the medicine.

• DMSO might slow blood clotting. Taking DMSO along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

• Using DMSO with sulindac might reduce how well sulindac works to treat pain. There is also a concern that using DMSO with sulindac can increase the risk for nerve pain.

• DMSO can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking DMSO with these medications might increase the chance of side effects.

• Using DMSO with verteporfin might reduce how well verteporfin works.

• Using DMSO to dissolve platinum agents onto the skin might reduce how well these drugs work to treat cancer. Examples of platinum agents include carboplatin, cisplatin, and oxaliplatin.

Dosing

DMSO has most often been applied to the skin by adults in various forms, including creams, gels, and solutions. It is also applied inside the bladder. DMSO is available as a prescription and in dietary supplements. Speak with a healthcare provider before use.

View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

Dimexide: instruction, price, analogues | Compendium – drug guide

Dimexide (dimethyl sulfoxide; DMSO; C2H6OS) is a small amphipathic organic molecule with a hydrophilic sulfoxide group and two hydrophobic methyl groups. Dimethyl sulfoxide (DMSO) is an unusual chemical derived from lignin, synthesized over 150 years ago. It is a highly polar, stable, hygroscopic organic liquid with exceptional solvent properties. Miscible with water, lipoids and organic solvents, it can lead to the formation of an unusually wide variety of inorganic and organic chemicals. Its industrial uses are many and varied: (1) as a solvent for resins, fungicides, dyes, pigments, etc. ; (2) as a reagent for chemical synthesis; (3) as an extractant; and (4) as a reaction medium for accelerating the rate of a chemical reaction. Dimethyl sulfoxide is a clear liquid, practically odorless. Flash point in closed cup 192°F. Vapors are heavier than air. Some describe it as having an “oyster” flavor, others claim it tastes like garlic. Skin contact may cause burning and garlic odor on breath. It is an excellent solvent that can transport solutions through the skin. High vapor concentrations of this compound can cause headache, dizziness, and sedation. Its medical use was first promoted by Stanley Jacob who reported in 1964 that DMSO readily penetrates the skin and transports small molecules across biological membranes.

So, today, Dimexide (DMSO) is a highly polar substance with exceptional solvent properties for both organic and inorganic chemicals and is widely used as an industrial solvent. DMSO has been reported to have a wide range of pharmacological activities, including membrane penetration, anti-inflammatory effects, local analgesia, mild bacteriostasis, diuresis, vasodilation, collagen dissolution, and free radical scavenging. The main use of dimethyl sulfoxide is as a carrier for drugs such as idoxuridine; promotes the penetration of the drug into the skin and, therefore, may enhance its effect. Clinical utility in surgery has been demonstrated in the treatment of acute trauma, postoperative pain in the area of ​​postoperative scars, certain urological disorders such as Peyronie’s disease; early Dupuytren’s contracture, keloids and subcutaneous fibrosis associated with cobalt exposure. DMSO effectively transports local anesthetics into the deeper layers of the skin and the eardrum, allowing pain-free incisions (The American Journal of Surgery). It is also used as a 50% aqueous solution for bladder instillation to relieve symptoms of interstitial cystitis; instill 50 ml and leave for 15 minutes. Treatment is repeated every 2 weeks. DMSO has been administered orally, intravenously, or topically for a wide range of indications, including skin and musculoskeletal disorders, but evidence of beneficial effects is limited. Dimethyl sulfoxide is used as a cryoprotectant for various human tissues. An essential pharmacological action of DMSO is its ability to scavenge oxygen-free radicals associated with tissue damage caused by xenobiotics when administered before, during, or several hours after tissue damage.

Dimexide is easily absorbed by all routes. Metabolized by oxidation to dimethyl sulfone and reduction to dimethyl sulfide. Dimexide and the sulfite metabolite are excreted in the urine and feces. Dimethyl sulfide is excreted through the lungs and skin and is responsible for the characteristic odor in patients. The maximum concentration in the blood is reached within 4-6 hours and remains at this level for 1.5-3 days. When used as a penetrating base for other topically applied drugs, dimexide can enhance their toxic effect. Hepatic and renal function should also be assessed at 6-month intervals. Bladder instillation may be detrimental to patients with urinary tract malignancies due to vasodilation. High concentrations of DMSO applied to the skin can cause burning discomfort, itching, erythema, vesiculation, and urticaria. Continued use may cause the problem to scale. Systemic effects including gastrointestinal disturbances, drowsiness, headache and hypersensitivity reactions may occur after use by any route. The garlic-like breath and skin odor is attributed to the use of DMSO (drugster.org, published October 26, 2018).

DMSO was first obtained by oxidation of dimethyl sulfide in 1866 by A. Zaitsev (student of A. Butlerov). A series of experiments were then started at the University of Oregon (to provide evidence that DMSO was an active permeant and an excellent transporter of other substances through the skin or tissue membranes). As a solvent, DMSO is superior even to water and is sometimes referred to as a “super solvent”. Chemical Characteristics – Dimexide is chemically classified as a dipolar aprotic hygroscopic solvent. Protic solvents such as water, methanol and formamide are hydrogen donors. Dipolar aprotic solvents, although possessing hydrogen atoms, are unable to donate labile hydrogen atoms and form strong hydrogen bonds with some other substances.

Although toxicity was reported in clinical studies of DMSO in the 1960s, the US Food and Drug Administration (FDA) later classified DMSO as the safest solvent. DMSO has become widely used in many biomedical fields and the biological effects have been overlooked. Meanwhile, biomedical science has evolved towards sensitive, high-throughput methods and new areas of research, including epigenomics and miRNAs. Given its widespread use, especially for cryopreservation and in vitro assays, we evaluated the biological effect of DMSO using these technological innovations.

Adverse reactions to DMSO are common but usually minor and are related to the concentration of DMSO in the drug solution. Therefore, the most common side effects, such as skin rash and itching after skin application, intravascular hemolysis after intravenous infusion, and gastrointestinal discomfort after oral administration, can largely be avoided by using more dilute solutions (Swanson B. N.).

Although DMSO is typically used at relatively low concentrations, it still has medically beneficial properties such as induction of an anti-inflammatory process, nerve block (analgesia), diuretics, vasodilation, and muscle relaxation. In addition, in cell biology, DMSO is also used as an inducer of cell differentiation, a free radical scavenger and a radioprotective agent, but most often for cryopreservation. Cell cultures for research are often stored in liquid nitrogen using a slow cooling methodology.

Dimethyl sulfoxide (DMSO), cell culture reagent, ideal for cryopreservation. In cryobiology, DMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues and cell suspensions. This is especially important for freezing and long-term storage of fetal and hematopoietic stem cells, which are often frozen in a mixture of 10% DMSO and 90% fetal calf serum (prevents the formation of ice crystals and thus reduces cell death). As part of an autologous bone marrow transplant, DMSO is re-administered along with the patient’s own hematopoietic stem cell. Dimexide is a polar aprotic organic solvent widely used in chemical and biological research. DMSO can uniquely provide solubility for some very polar small molecules such as simple biomolecules with few proton functional groups. It can also be used as an oxidizing agent in certain transformations. The yield of polymerase chain reaction (PCR) processes is enhanced by using DMSO as a co-solvent, helping to inhibit the formation of secondary structures from DNA fragments.

Each application of Dimexide appears to provide rapid temporary pain relief in patients with arthritis and connective tissue damage. However, an anti-inflammatory effect or accelerated healing is currently unjustified. There is no evidence that DMSO can alter the progression of degenerative joint disease, and for this reason, DMSO can only be considered for palliative care (relieving the symptoms of the disease) and not for avoiding standard anti-inflammatory agents. Dimexide is currently widely used in research in inflammatory conditions such as rheumatoid arthritis, clinical trials are underway to study it, although it is difficult to draw any conclusions from them, since the garlic odor generated by the DMSO metabolite, DMS, is negative affects the reliability of a double-blind study.

To date, studies of the efficacy of DMSO in animal models of rheumatoid arthritis have yielded conflicting results. Since DMSO is known to impair cell permeability and cause cell death at high concentrations, a study was conducted that examined the relationship of anti-inflammatory properties with its effect on cell viability. The results show that DMSO up to a final concentration of 1% induces little cytotoxicity for monocytes, but there is a significant decrease in monocytes by 2%, slight hemolysis by 5%, and a sharp decrease in PBMCs (from English peripheral blood mononuclear cells) by 10%. Thus, DMSO has only a narrow therapeutic window and it is possible that the decrease in cytokines/chemokines at 2% DMSO is associated with lower monocyte viability. However, the effects of DMSO at concentrations of 0.5% and below are probably independent of cytotoxicity. DMSO is an anti-inflammatory agent that has been shown to be effective in human whole blood. This is due to a decrease in the production of inflammatory mediators. The study concluded that the use of DMSO as an anti-inflammatory agent in conditions such as rheumatoid arthritis may have some benefits (Ingrid Elisia et al., 2016).

Data on the analgesic effects of Dimexide itself is mixed. However, when DMSO is used as a carrier for other analgesics, it increases the effectiveness of these agents (lidocaine in one study, diclofenac in another) and reduces symptoms. Pain relief with immediate application is reported almost immediately and lasts up to 6 hours. This has made DMSO ideal for the management of acute pain in athletes requiring immediate relief. To reduce chronic pain, patients may need to use DMSO for up to 6 weeks before any therapeutic effect is noticeable.

DMSO enhances the diffusion of other chemicals through the skin and for this reason a mixture of idoxuridine and DMSO is used for topical treatment of herpes zoster in the UK. Dimethyl sulfoxide (DMSO) is currently used as an alternative treatment for various inflammatory conditions as well as cancer. Dimexide was first used for the treatment of acute soft tissue diseases such as bursitis and tendinitis. However, despite extensive rave evidence of efficacy, two controlled studies have yielded conflicting results (Trice J.M., Pinals R.S., 1985). However, at present Dimexide is indispensable for biotechnological applications. In these cases, one should take into account the effects that DMSO can have and keep the concentration as low as possible, since even at low concentrations DMSO is not inert (Verheijen M., Schrooders Y. et al., 2019). It should be borne in mind that, in addition to facilitating the absorption of other drugs, DMSO can also enhance their effect. Therefore, drug interactions should always be assessed prior to use, especially given the fact that in some cases drug levels can reach the toxic limit and increase the risk to patients’ lives. Reactions such as nausea, vomiting, diarrhea, rash, skin redness, and in rare cases bronchospasm are known (Zenhausern et al., 2000; Crivellenti et al., 2013).

However, even now Dimexide continues to be the subject of controversy, controversy and reports of various kinds in the media. For the most part, clinical studies with DMSO do not meet the most standard requirements for conducting controlled studies in rheumatic diseases. The main problem was the difficulty in hiding the presence of DMSO due to its characteristic odor and in developing a suitable placebo. Much interesting information about DMSO has accumulated in recent years, including evidence of its relative safety, but its therapeutic role and its legitimacy in medical practice remains in limbo, pending further substantiation of efficacy in well-designed clinical trials.

purpose and use in medicine and cosmetology

Contents

• 1 Dimexide: an indispensable tool in medicine and cosmetology
  • 1.1 Dimexide: properties and uses
    • 1.1.1 Properties of Dimexide 9007 4
    • 1.1.2 Application of dimexide
  • 1.2 How Dimexide works
  • 1.3 Medical uses of Dimexide
    • 1.3.1 Diseases of bones and joints
    • 1.3.2 Wounds and burns
    • 1.3.3 Dermatology
    • 1.3.4 Injuries and bruises
  • 1.4 Use of dimexide in cosmetology
  • 1.5 Use of dimexide in agriculture
    • 1.5.1 Protection of plants from pests and diseases

    9006 9 1.5.2 Yield increase

    • 1.5.3 Evaluation of results
  • 1.6 Use of dimexide in everyday life
    • 1.6.1 For the treatment of wounds and burns
    • 1.6.2 For the treatment of inflammatory diseases
    • 1.6.3 For the improvement of skin condition
  • 1.7 Rules for the use of dimexide
    • 1. 7.1 Appointment and dosage
    • 1.7.2 Methods of application
    • 1.7.3 Contraindications and side effects

  90 069 1.8 Side effects of dimexide

  • 1.9 Related videos:
  • 1.10 Question-answer:
    • • 1.10.0.1 What is dimexide for?
      • 1.10.0.2 Can dimexide be used to treat herpes?
      • 1.10.0.3 How to use dimexide correctly in the treatment of external wounds?
      • 1.10.0.4 What are the contraindications to the use of dimexide?
      • 1.10.0.5 Can dimexide be used for angina?
      • 1.10.0.6 What effect does dimexide have on the body?
  • 1.11 Contraindications to the use of dimexide
    • 1.11.1 Pregnancy and lactation
    • 1.11.2 Large affected skin areas sensitivity to dimexide
    • 1.11.4 Pathologies of the liver and kidneys
  • 1.12 Where can I buy Dimexide?

Dimexide is an effective drug that is used to treat various diseases. It has anti-inflammatory, antiseptic, bactericidal and antifungal effects. Find out what else dimexide can be used for and how to use it correctly.

Dimexide is a powerful antibacterial and anti-inflammatory agent that has found wide application in medicine. It has many useful properties due to which it is used in the treatment of various diseases.

One of the most important qualities of Dimexide is its ability to penetrate the skin and other human tissues, providing a deep effect of action and accelerating the treatment process.

In this article, we will look at the main properties of Dimexide, how it can be used, and the benefits it can provide in the treatment of various diseases associated with inflammation and infection.

It is important to note that dimexide is a drug and should be used only after consulting a doctor and following the instructions for use.

Dimexide: properties and uses

Properties of Dimexide

Dimexide is a medicinal product that has anti-inflammatory, antimicrobial and analgesic effects. It has the ability to quickly penetrate the skin and increase the permeability of cells to drugs. This property makes dimexide very effective in combination with other drugs.

In addition, dimexide is able to improve blood circulation at the site of inflammation, accelerate the process of tissue regeneration, as well as relieve pain and swelling. 9All of the above 0%

Use of dimexide

• For the treatment of diseases of the musculoskeletal system – sciatica, arthritis, osteochondrosis, sciatica, bursitis, tendinitis;
• For the treatment of skin diseases – psoriasis, eczema, fungal infections, burns, wounds;
• For the treatment of eye diseases – conjunctivitis, keratitis, blennorrhea;
• For the treatment of oral diseases – periodontitis, gingivitis, stomatitis;
• For the treatment of respiratory diseases – bronchitis, pneumonia, influenza;

Dimexide can be used alone or in combination with other drugs to treat these diseases. Before using dimexide, you must read the instructions and consult with your doctor.

How Dimexide works

Dimexide is a drug with anti-inflammatory, analgesic and antimicrobial effects. It is able to quickly penetrate into the deeper layers of the skin, strengthen capillaries and activate blood circulation, which improves tissue metabolism and accelerates the healing process.

In addition, dimexide is able to penetrate the skin into the bloodstream and have a significant effect on the human body. It has a local and general effect, is able to lower blood pressure and reduce heart rate, improve the functioning of the nervous and immune systems, and also reduce pain.

Dimexide is used to treat a variety of conditions such as bruises, sprains, rheumatism, arthritis, osteochondrosis, etc. It can be used alone or in combination with other drugs. In addition, dimexide does an excellent job of fighting various infections due to its antimicrobial properties.

• Conclusion: Dimexide is a powerful and effective drug, which, due to its anti-inflammatory, analgesic and antimicrobial properties, is used to treat various diseases. Its unique effect on the skin and the body as a whole makes it indispensable for the treatment of many pathologies.

Use of dimexide in medicine

Diseases of bones and joints

Dimexide is used to treat diseases of bones and joints, such as arthritis, arthrosis, osteochondrosis and traumatic injuries. Its medicinal properties help reduce pain, reduce inflammation and swelling, and improve blood circulation. Dimexide penetrates the skin and has a local effect on the diseased area.

Wounds and burns

Dimexide is also used in medicine for the treatment of wounds and burns. It has anti-inflammatory and antibacterial properties and also promotes wound healing. For the treatment of wounds and burns, it is used in the form of compresses or ointments.

Dermatology

Dimexide is widely used in dermatology for the treatment of skin conditions such as eczema, psoriasis and dermatitis. It improves microcirculation and heals the skin, helps reduce itching and redness. Dimexide also helps the absorption of other drugs that are applied to the skin. It is added to the composition of ointments and creams for external use.

Injuries and bruises

Dimexide can be used for injuries and bruises. It reduces pain and swelling and speeds up the healing process. Often it is used in conjunction with other drugs to enhance their effect. For external use, it is added to compresses and ointments. In case of pain inside, dimexide can be administered in the form of droppers, accelerating the healing process.

Use of dimexide in cosmetology

Dimexide is a drug that has found wide application in cosmetology due to its anti-inflammatory and bactericidal properties.

One of the main uses of dimexide in cosmetology is the treatment of various skin diseases such as acne, eczema, psoriasis and dermatitis. It helps reduce inflammation and speed up the repair process of skin tissues.

Dimexide is also used in face masks and creams to moisturize and nourish the skin, improve its color and texture, and prevent wrinkles and other signs of aging.

Dimexide is also used in skin exfoliation treatments to help exfoliate the top layer of skin, stimulate skin renewal and even out color.

However, it must be remembered that dimexide can cause allergic reactions and should not be used without a prescription from a specialist.

Use of dimexide in agriculture

Protection of plants from pests and diseases

Dimexide is an effective antimicrobial and analgesic agent, which is actively used in agriculture to combat pests and plant diseases.

One of the main advantages of using dimexide is its rapid and effective action on pathogenic microorganisms that cause plant diseases. In addition, dimexide is a powerful insecticide that helps protect plants from harmful insects.

To control plant pests and diseases, dimexide should be used as a component in solutions consisting of several chemicals. For example, dimexide can be used in combination with fungicides, insecticides and herbicides.

Yield increase

The use of dimexide helps to increase plant yield. For example, it can be used to speed up bulb growth and improve grain quality.

Dimexide is also used in agriculture to increase the yield of seedlings and free amino acids. This allows you to increase the nutritional value of products and make them more competitive in the market.

Evaluation of results

The use of dimexide in agriculture can lead to positive or negative results. To evaluate the results of using this drug, it is necessary to conduct regular tests for the content of dimexide in plants and soil.

Also be aware that dimexide can be toxic to plants if used in the wrong amount. Therefore, the correct proportions in solutions should be observed and the dosage of the drug should not be exceeded.

Household use of Dimexide

For the treatment of wounds and burns

Dimexide is a clear liquid with medicinal properties, often used to treat wounds and burns. This drug has a powerful antiseptic, antibacterial and anti-inflammatory effect and is able to quickly relieve pain and reduce swelling. For the treatment of wounds and burns, dimexide should be diluted with water in a ratio of 1: 4 and applied as a compress to the affected area.

For the treatment of inflammatory diseases

In everyday life Dimexide is used to treat inflammatory diseases such as arthritis, osteochondrosis, sciatica and many others. The use of dimexide in such diseases allows you to quickly relieve pain, reduce swelling and improve joint movement. For the treatment of inflammatory diseases, dimexide should be diluted with water in a ratio of 1: 3 and applied to the affected area of ​​the skin.

To improve the condition of the skin

Dimexide is also used to improve the condition of the skin. This drug is able to open the pores of the skin and improve the penetration of nutrients into the upper layers of the skin. To improve the condition of the skin, dimexide should be diluted with water in a ratio of 1: 5 and applied to the skin of the face or body in the form of a mask.

• In conclusion, Dimexide is a versatile drug that can be used to treat wounds and burns, improve skin conditions and treat various inflammatory diseases.
• However, before using Dimexide, it is necessary to consult a doctor and test for an allergic reaction.

How to use Dimexide

Indication and dosage

Dimexide is a powerful anti-inflammatory drug that can be used to treat a variety of diseases and conditions. For each case, their dosage of the drug is prescribed, which must be observed.

During an exacerbation of the disease, dimexide at an increased concentration should be used – from 30% to 50%. For the treatment of pain and inflammation of moderate and mild severity, Dimexide 10-25% concentration can be used.

How to use

Dimexide can be used alone or in combination with other drugs. There are different ways to use dimexide, including:

• Compresses and ointments. In this case, dimexide is applied to the affected part of the body in the form of a compress or ointment, left for several hours or overnight.
• Inhalation. In diseases of the respiratory tract, dimexide is dissolved in boiled water and inhaled.
• Oral use. Dimexide can be used in drops or tablets only after a doctor’s prescription.

Contraindications and side effects

Before using dimexide, you should consult your doctor and read the contraindications:

1. Individual intolerance
2. Pregnancy and lactation
3. Pathologies of the kidneys, liver, brain.

Dimexide may cause side effects: skin redness and irritation, allergic reactions, nausea, vomiting and headache. If these symptoms begin to appear, it is necessary to reduce the concentration of the drug or stop its use completely.

Dimexide side effects

Dimexide is a powerful medicine that can cause side effects. In some cases, the use of dimexide can lead to skin irritation, dryness, burning and redness.

The acute reactive action of dimexide may cause an allergic reaction in people prone to allergies. There may also be a violation of smell, the smell of the compound has a pronounced character.

Dimexide can penetrate into the circulatory system and cause disturbances in its functioning, therefore it is not recommended for use in diseases of the genitourinary system, pregnancy and in breastfeeding women.

• skin irritation
• allergic reactions
• olfactory disorders
• disorders of the cardiovascular and genitourinary systems

Before using dimexide, it is recommended to consult a doctor and carefully study the instructions for use of the drug.

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Q&A:

What is dimexide for?

Dimexide is a drug that is widely used in medicine. It has powerful anti-inflammatory, antibacterial and antioxidant properties. The use of dimexide helps to accelerate wound healing, reduce swelling and pain at the site of injury, and improve the penetration of drugs through the skin. In cosmetology, dimexide is used to improve skin condition, reduce wrinkles and pigmentation.

Can dimexide be used to treat herpes?

Dimexide is not a drug that is used directly to treat herpes. However, due to its properties, dimexide can accelerate the healing of wounds that often occur with herpes. Before using dimexide in the treatment of herpes, it is necessary to consult a specialist and choose the optimal treatment regimen.

How to use dimexide in the treatment of external wounds?

For external use dimexide should be diluted 1:4 (1 part Dimexide and 4 parts water). Dissolved dimexide is applied to the wound and left for several minutes, after which it is washed with water. The procedure is repeated several times a day. Dimexide can be used in combination with local antibiotics to speed up healing.

What are the contraindications to the use of dimexide?

Dimexide is contraindicated in case of individual intolerance, pregnancy and breastfeeding, damage to the optic nerve, glaucoma, cataracts and other eye diseases, liver and kidney diseases, atherosclerosis. It is also not recommended to use dimexide in its pure form. Before using dimexide, you should consult with a specialist.

Can dimexide be used for angina?

Dimexide can be used to treat angina as a component of topical or inhalation treatment. However, when using dimexide for the treatment of angina, a certain dosage must be observed and not exceed the recommended doses. In addition, it is necessary to consult with a specialist and choose the optimal treatment regimen, including additional drugs.

What effect does dimexide have on the body?

Dimexide has powerful anti-inflammatory, antibacterial and antioxidant properties. It can speed up wound healing, reduce swelling and pain at the injury site, and improve the penetration of drugs through the skin. When using Dimexide, side effects may occur, such as blurred vision, dryness and irritation of the skin, nausea, vomiting, headache, allergic reactions, etc. Before using Dimexide, you should consult a specialist and familiarize yourself with the possible risks and contraindications for use.

Contraindications to the use of Dimexide

Pregnancy and lactation

The use of Dimexide during pregnancy and lactation is highly undesirable. This drug is made on the basis of dimethyl sulfoxide, which can cross the placenta and enter breast milk, causing serious disturbances in the development of the fetus and the health of the child.

Large affected areas of the skin

The use of Dimexide on large affected areas of the skin is highly undesirable, as it can cause burns, swelling and dilation of capillaries. This drug should be used only on small areas of the skin in order to avoid serious complications.

Hypersensitivity to Dimexide

The use of Dimexide is strictly prohibited in case of hypersensitivity to this drug. In case of allergic reactions, you should immediately stop using the drug and consult a doctor.

Pathologies of the liver and kidneys

The use of dimexide is highly undesirable in the presence of pathologies of the liver and kidneys. This drug can cause serious complications in the work of the organs and deterioration of the general condition of the patient.

Where can I buy Dimexide?

Dimexide is a medicinal product and to purchase it you need to go to pharmacies or online stores specializing in medical products. This drug belongs to the prescription category, so it can only be bought with a prescription from a doctor.

Dimexide is currently available throughout Russia. To do this, you need to contact the nearest pharmacy that has a license to sell medicines, or an online store specializing in the sale of medicines.

When buying dimexide in an online store, you should pay attention not only to the price, but also to the quality of the product.