What are the primary uses of DMSO solution. How does DMSO affect the body. What precautions should be taken when using DMSO. What are the potential side effects of DMSO use. How does DMSO interact with other medications.

Understanding DMSO: An Overview of Dimethyl Sulfoxide

Dimethyl sulfoxide, commonly known as DMSO, is a versatile chemical compound with a wide range of applications in medicine and industry. This colorless liquid has the unique ability to dissolve numerous organic and inorganic substances, making it a valuable tool in various fields. But what exactly is DMSO, and how does it work?

DMSO is a polar aprotic solvent, meaning it can dissolve both polar and non-polar compounds. This property allows it to penetrate biological membranes easily, including the skin. As a result, DMSO has gained attention for its potential to enhance the delivery of other substances into the body.

The Chemistry Behind DMSO’s Efficacy

The molecular structure of DMSO consists of a sulfur atom bonded to two methyl groups and an oxygen atom. This arrangement gives DMSO its unique properties, including:

• High polarity
• Low toxicity
• Ability to penetrate cellular membranes
• Capacity to act as a carrier for other substances

These characteristics contribute to DMSO’s effectiveness in various medical applications. How does DMSO’s chemical structure influence its interaction with biological systems? The molecule’s polarity allows it to form hydrogen bonds with water, while its hydrophobic methyl groups enable it to interact with lipid membranes. This dual nature facilitates DMSO’s ability to transport other molecules across cellular barriers.

Medical Applications of DMSO: From Bladder Inflammation to Pain Management

DMSO has garnered significant interest in the medical community due to its diverse potential applications. While some uses are FDA-approved, others remain under investigation. What are the primary medical uses of DMSO?

FDA-Approved Use: Interstitial Cystitis Treatment

The most well-established medical use of DMSO is in the treatment of interstitial cystitis, a chronic condition characterized by bladder pain and pressure. How does DMSO help in this context? When instilled into the bladder, DMSO can reduce inflammation and alleviate pain associated with interstitial cystitis. This FDA-approved treatment has shown significant efficacy in improving patients’ quality of life.

Potential Applications in Pain Management

Beyond its approved use, DMSO has shown promise in managing various types of pain. Research suggests that topical application of DMSO may help alleviate symptoms of complex regional pain syndrome, a chronic condition that typically affects limbs after injury. What makes DMSO effective in pain management? Its ability to penetrate the skin and its anti-inflammatory properties may contribute to its pain-relieving effects.

DMSO in Cancer Treatment Support

While not a primary cancer treatment, DMSO has found a role in managing complications associated with chemotherapy. Specifically, it may help prevent tissue damage caused by the extravasation of certain chemotherapy drugs. How does DMSO protect against chemotherapy-induced tissue damage? Its ability to penetrate tissues quickly may allow it to neutralize or dilute extravasated drugs before they cause significant harm.

The Mechanism of Action: How DMSO Affects the Body

Understanding how DMSO interacts with the human body is crucial for appreciating its potential benefits and risks. What are the primary ways DMSO affects biological systems?

• Enhanced membrane permeability
• Interaction with proteins and nucleic acids
• Antioxidant properties
• Anti-inflammatory effects

DMSO’s ability to enhance membrane permeability is perhaps its most notable characteristic. This property not only allows DMSO to penetrate tissues easily but also enables it to carry other substances across biological barriers. How does this enhanced permeability affect drug delivery? It can potentially increase the absorption and efficacy of certain medications when used in combination with DMSO.

Moreover, DMSO’s interaction with proteins and nucleic acids may contribute to its biological effects. It can alter protein structure and function, potentially influencing various cellular processes. The compound’s antioxidant and anti-inflammatory properties further contribute to its therapeutic potential, particularly in the context of pain management and tissue protection.

Safety Considerations: Side Effects and Precautions of DMSO Use

While DMSO offers numerous potential benefits, it’s crucial to consider its safety profile and potential side effects. What are the primary concerns associated with DMSO use?

Common Side Effects

When applied topically or instilled into the bladder, DMSO may cause:

• Skin irritation or burning sensation
• Garlic-like breath odor or taste
• Headache
• Dizziness
• Nausea

These side effects are generally mild and transient. However, their occurrence underscores the importance of using DMSO under medical supervision.

Safety Precautions and Contraindications

Are there specific situations where DMSO use should be avoided or approached with caution? Indeed, several precautions should be considered:

1. Pregnancy and breastfeeding: Due to limited safety data, DMSO use is generally not recommended during pregnancy or while breastfeeding.
2. Blood disorders: DMSO may affect red blood cells, potentially exacerbating certain blood disorders.
3. Kidney or liver problems: DMSO metabolism involves these organs, so caution is advised in patients with kidney or liver issues.
4. Skin conditions: The penetrating nature of DMSO may exacerbate certain skin conditions or increase the absorption of harmful substances through damaged skin.

It’s crucial to consult a healthcare professional before using DMSO, especially for individuals with pre-existing medical conditions or those taking other medications.

DMSO Interactions: Potential Effects on Other Medications

DMSO’s ability to enhance membrane permeability and its chemical properties can lead to interactions with various medications. What are the key interactions to be aware of when using DMSO?

Enhanced Drug Absorption

DMSO can increase the absorption of other medications, particularly when applied topically. This effect can potentially enhance the efficacy of certain drugs but may also increase the risk of side effects. Which types of medications are most likely to be affected? Topical medications, including corticosteroids and analgesics, may show increased absorption when used in conjunction with DMSO.

Blood Thinners and Anticoagulants

DMSO may have a mild anticoagulant effect. When combined with blood-thinning medications, this could potentially increase the risk of bleeding. How should patients on anticoagulants approach DMSO use? Close monitoring and consultation with a healthcare provider are essential to adjust dosages if necessary.

Acetylcholinesterase Inhibitors

DMSO can increase levels of acetylcholine in the body. When used alongside medications that also affect acetylcholine levels, such as those used for Alzheimer’s disease or glaucoma, there may be an increased risk of side effects. What symptoms should patients watch for? Excessive salivation, sweating, or gastrointestinal disturbances may indicate an interaction.

Proper Use and Dosing: Maximizing DMSO’s Benefits Safely

To harness the potential benefits of DMSO while minimizing risks, proper use and dosing are crucial. How should DMSO be used for maximum safety and efficacy?

Topical Application

When applied to the skin, DMSO is typically used in concentrations ranging from 10% to 70%. The appropriate concentration depends on the specific condition being treated and should be determined by a healthcare professional. How should topical DMSO be applied?

• Clean and dry the application area thoroughly
• Apply a thin layer of DMSO using a clean applicator
• Allow the area to air dry
• Wash hands thoroughly after application

It’s important to note that the frequency of application can vary depending on the condition and individual response. Always follow the guidance of a healthcare provider.

Intravesical Use for Interstitial Cystitis

For the treatment of interstitial cystitis, DMSO is typically instilled directly into the bladder. What does this procedure involve? A healthcare professional will insert a catheter to deliver a 50% DMSO solution into the bladder. The solution is usually retained for about 15 minutes before being drained. This treatment is typically repeated every one to two weeks for six to eight weeks, with maintenance treatments as needed.

Importance of Medical Supervision

Given the potential for side effects and interactions, DMSO should only be used under the guidance of a healthcare professional. Regular monitoring and follow-up are essential to ensure safe and effective use. How often should patients using DMSO be evaluated? The frequency of check-ups will depend on the specific condition being treated and the individual’s response to therapy, but regular monitoring is crucial for all DMSO applications.

Future Perspectives: Emerging Research and Potential Applications of DMSO

As research into DMSO continues, new potential applications and insights are emerging. What areas of DMSO research are currently showing promise?

Neuroprotective Properties

Recent studies have suggested that DMSO may have neuroprotective effects, potentially benefiting conditions such as stroke or traumatic brain injury. How might DMSO protect neural tissue? Its antioxidant properties and ability to reduce inflammation may play a role in mitigating neuronal damage.

Drug Delivery Systems

DMSO’s ability to enhance membrane permeability is driving research into its use in advanced drug delivery systems. Could DMSO revolutionize how certain medications are administered? Researchers are exploring DMSO-based formulations that could improve the efficacy of various drugs, particularly those that struggle with bioavailability.

Cryopreservation

DMSO’s role in cryopreservation of biological materials is well-established, but ongoing research is refining its use. How might improvements in DMSO-based cryopreservation techniques impact medicine? Enhanced preservation methods could have significant implications for organ transplantation and stem cell therapies.

As research progresses, our understanding of DMSO’s potential benefits and risks continues to evolve. While its current approved uses are limited, ongoing studies may uncover new applications that could expand DMSO’s role in medicine. However, it’s crucial to approach these potential new uses with caution, ensuring thorough scientific validation before clinical implementation.

Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Dimethylsulfoxide (DMSO) is a chemical that dissolves many organic and inorganic substances. It’s available as a prescription drug and dietary supplement.

DMSO helps medicines get through the skin and can affect proteins, carbohydrates, fats, and water in the body.

People use DMSO for bladderinflammation (interstitial cystitis), limb pain that usually occurs after an injury, and leakage of an IV drug from the vein into surrounding skin and tissue. It is also used for osteoarthritis, bed sores, stomach ulcers, and many other conditions, but there is no good scientific evidence to support most of these other uses.

Don’t confuse DMSO with Methylsulfonylmethane (MSM). These are not the same.

Uses & Effectiveness ?

Effective for

• Painful bladder syndrome (interstitial cystitis). DMSO is an FDA-approved product for the treatment of this condition. Washing the bladder with DMSO improves some symptoms, such as pain.

Possibly Effective for

• Limb pain that usually occurs after an injury (complex regional pain syndrome). Applying DMSO cream to the skin seems to improve pain in people with this condition.
• Leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation). Some chemotherapy drugs can cause skin and tissue damage if they leak from the vein. Applying DMSO to the skin might prevent further damage if this happens.

Possibly Ineffective for

• Hardening of skin and connective tissue (scleroderma). Applying DMSO to the skin doesn’t help treat symptoms of scleroderma.

There is interest in using DMSO for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Special Precautions and Warnings

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Pregnancy and breast-feeding: There isn’t enough reliable information to know if DMSO is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Certain blood disorders. Injecting DMSO by IV might cause red blood cells to break down. This might be a problem for people with certain blood disorders. DMSO might make these conditions worse.

Kidney problems: DMSO might harm the kidneys. Check with a healthcare provider before using DMSO if you have kidney problems.

Liver problems: DMSO might harm the liver. Check with a healthcare provider before using DMSO if you have liver problems.br/>

Interactions ?

Moderate Interaction

Be cautious with this combination

• DMSO can sometimes increase how much medicine the body absorbs. Applying DMSO to the skin, eyes, or ears at the same time as applying medication can increase how much medicine the body absorbs. This might increase the effects and side effects of the medicine.

• DMSO might slow blood clotting. Taking DMSO along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

• Using DMSO with sulindac might reduce how well sulindac works to treat pain. There is also a concern that using DMSO with sulindac can increase the risk for nerve pain.

• DMSO can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking DMSO with these medications might increase the chance of side effects.

• Using DMSO with verteporfin might reduce how well verteporfin works.

• Using DMSO to dissolve platinum agents onto the skin might reduce how well these drugs work to treat cancer. Examples of platinum agents include carboplatin, cisplatin, and oxaliplatin.

Dosing

DMSO has most often been applied to the skin by adults in various forms, including creams, gels, and solutions. It is also applied inside the bladder. DMSO is available as a prescription and in dietary supplements. Speak with a healthcare provider before use.

View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

DMSO: Uses and Risks

Written by Joseph Saling

• Why Do People Use DMSO?
• What Are the Risks of Using DMSO?

DMSO, or dimethyl sulfoxide, is a by-product of paper making. It comes from a substance found in wood.

DMSO has been used as an industrial solvent since the mid-1800s. From about the mid-20th century, researchers have explored its use as an anti-inflammatory agent.

The FDA has approved DMSO as a prescription medication for treating symptoms of painful bladder syndrome. It’s also used under medical supervision to treat several other conditions, including shingles.

DMSO is easily absorbed by the skin. It’s sometimes used to increase the body’s absorption of other medications.

DMSO is available without a prescription most often in gel or cream form. It can be purchased in health food stores, by mail order, and on the Internet.

While it can sometimes be found as an oral supplement, its safety is unclear. DMSO is primarily used by applying it to the skin.

DMSO has been used to try to relieve the pain of osteoarthritis. It has also been promoted as an “alternative” cancer treatment.

People have used it to try to treat wounds, burns, and other injuries. People have also used it to try to treat such conditions as:

• Headache
• Rheumatoid arthritis
• Eye problems
• Scars
• Scleroderma (disease that causes scar tissue to form in the skin)

Other than its use as a prescription medicine, there is little or no scientific evidence to support other claims made about DMSO’s effectiveness.

The American Cancer Society says there is no evidence to support the use of DMSO to treat cancer. Using it that way could cause serious delays in getting proper and effective treatment.

A recent analysis of studies on the use of DMSO to relieve osteoarthritis pain found that it was not significantly more effective than placebo in relieving joint pain.

There are no studies that provide guidelines for determining the proper dose of DMSO. The gel used to treat osteoarthritis typically has a concentration of 25%. It is applied three or four times a day. But DMSO sold without a prescription can range from 10% concentration to 90%.

Some DMSO on the market may actually be industrial grade. Industrial grade DMSO may contain a number of impurities that can easily be absorbed into the skin with potentially serious health effects.

The most frequent side effects from using DMSO on the skin include:

• Stomach upset
• Skin irritation
• Strong odor of garlic

More serious side effects include:

• Severe allergic reactions
• Headaches
• Itching and burning when applied to the skin

DMSO can also cause a deadly reaction when used in high concentrations.

Using DMSO by mouth can cause:

• Dizziness
• Drowsiness
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Decreased appetite

DMSO can increase the effect of some medicines, which can lead to serious health issues. Examples of such medicines include:

• Blood thinners
• Steroids
• Sedatives

The biggest concern of DMSO as a solvent is that when it gets on the skin it will cause anything on the skin to be absorbed. So be sure to wash your hands and skin well before using.

Pregnant women and women who are breastfeeding should not use DMSO, since little is known about its possible effects on the fetus or infant.

You should also not use DMSO without talking to your doctor if you have:

• Diabetes
• Asthma
• Liver and kidney conditions

Always keep in mind that supplements are not regulated by the FDA the same was as drugs are. The manufacturer does not have to prove that a supplement is safe or effective before selling.

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Adult Medication

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Provided by Lexicomp ^® , this document contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Rimso-50

Trade names: Canada

Rimso-50

What is this drug used for?

• It is used to relieve pain, reduce inflammation and reduce bladder irritation.
• If you have been taking this drug for any other reason, ask your doctor about the benefits and risks. If you have questions or concerns about using this drug, talk with your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.

Combining this drug with certain drugs and conditions may be unfavorable.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Get a blood test and an eye exam as directed by your doctor.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Vision changes, eye pain or severe eye irritation.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Irritation at the site of application of the drug.
• When taking this drug, the skin and breath acquired a smell reminiscent of garlic. The odor may persist for up to 72 hours after using this drug.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

• The drug is injected through a catheter into the bladder.
• You need to urinate after taking this drug. This helps to remove the drug from the bladder. Drink large amounts of decaffeinated fluids during or immediately after taking this drug, unless your doctor tells you otherwise. Continue drinking fluids as directed by your doctor.

What if I miss a dose of a drug?

• See your doctor for further instructions.

How do I store and/or discard this drug?

• If you need to store this drug at home, check with your doctor, nurse, or pharmacist for storage conditions.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.
• Some medicines may come with other patient information leaflets. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www. wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2021-06-25

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Date last updated

Monday, December 12, 2022

Description DIMETHYL SULFOXIDE indications, dosages, contraindications of the active substance DIMETHYL SULFOXIDE

Rec.INN registered by WHO Included in preparations: list Pharmacological action Anti-inflammatory agent for external use. The mechanism of action is associated with the inactivation of hydroxyl radicals and the improvement of metabolic processes in the focus of inflammation, a decrease in the rate of conduction of excitatory impulses in peripheral neurons. It has a local anesthetic, local anti-inflammatory, analgesic and antimicrobial effect; has some fibrinolytic activity. Penetrates through the skin and other biological membranes, increases their permeability to drugs. Pharmacokinetics When a solution of dimethyl sulfoxide is applied to the skin, it is detected in the blood after 5 minutes, C max is reached after 4-6 hours, maintaining an almost unchanged level for 1.5-3 days. Dimethyl sulfoxide is excreted in the urine and feces, both unchanged and as dimethyl sulfone. Indications of the active substance DIMETHYLSULPHOXIDE As part of complex therapy: diseases of the musculoskeletal system: rheumatoid arthritis, ankylosing spondylitis (Bekhterev’s disease), deforming osteoarthrosis (in the presence of damage to periarticular tissues), reactive synovitis, limited scleroderma, erythema nodosum, discoid lupus erythematosus, mycosis of the feet, keloid scars, thrombophlebitis, alopecia, eczema, streptoderma, erysipelas; bruises, sprains, traumatic infiltrates; purulent wounds, burns, sciatica, trophic ulcers, acne, furunculosis; in skin plastic surgery – for preservation of skin homotransplants. Open list of ICD-10 codes A46 erysipelas B35.3 Foot mycosis I80 Phlebitis and thrombophlebitis L02 Skin abscess, furuncle and carbuncle L08.0 Pyoderma L20.8 Other atopic dermatitis (neurodermatitis, eczema) L30.0 Coin-shaped eczema L52 Erythema nodosum L63.9 Alopecia areata, unspecified L64. 9 Androgenetic alopecia, unspecified L70 Acne L91.0 Hypertrophic scar L93.0 Discoid lupus erythematosus L94.0 Localized scleroderma [morphea] L98.4 Chronic skin ulcer, not elsewhere classified M05 Seropositive rheumatoid arthritis M15 Polyarthrosis M45 Ankylosing spondylitis M54.1 Radiculopathy M54. 3 Sciatica M54.4 Lumbago with sciatica M65 Synovitis and tenosynovitis T14.0 Superficial injury of an unspecified area of ​​the body (incl. abrasion, bruising, contusion, hematoma, non-venomous insect bite) T14.3 Dislocation, sprain and strain of the capsular-ligamentous apparatus of the joint of an unspecified area of ​​the body T30 Thermal and chemical burns, unspecified T79.3 Post-traumatic wound infection, not elsewhere classified Dosing regimen Apply externally. In the form of applications and irrigations (washings). The concentration of the solution and the solvent is determined depending on the application. The duration of treatment is 10-15 days. Side effects Possible: allergic reactions, pruritic dermatitis, contact dermatitis, erythema, dry skin, mild burning, pruritic dermatitis. Rare: bronchospasm. Contraindications for use Hypersensitivity to dimethyl sulfoxide; severe hepatic and / or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataracts, stroke, coma, myocardial infarction; pregnancy; breastfeeding period; children’s age up to 12 years. Use in pregnancy and lactation Dimethyl sulfoxide is contraindicated in pregnancy and lactation. Use in hepatic impairment Contraindicated in severe hepatic impairment. Use in impaired renal function Contraindicated in severe renal impairment. Use in children Use in children under 12 years of age is contraindicated. Leave a Reply Cancel reply Your email address will not be published. Required fields are marked * Comment * Name * Email * Website