What are the primary uses of DMSO solution. How does DMSO affect the body. What precautions should be taken when using DMSO. What are the potential side effects of DMSO usage. How does DMSO interact with other medications.

Understanding DMSO: Chemical Properties and Medical Applications

Dimethylsulfoxide (DMSO) is a versatile chemical compound with unique properties that have garnered significant attention in the medical field. As an organic solvent, DMSO possesses the remarkable ability to dissolve a wide range of organic and inorganic substances. This characteristic makes it particularly useful in various medical applications, especially in drug delivery systems.

DMSO’s ability to penetrate biological membranes has led to its use as a vehicle for transdermal drug delivery. When applied to the skin, DMSO can enhance the absorption of other substances, potentially increasing the efficacy of topical medications. This property has made DMSO a subject of interest in the development of novel drug delivery methods.

How does DMSO work in the body?

DMSO’s mechanism of action in the body is multifaceted. It can affect various biological molecules, including proteins, carbohydrates, lipids, and water. This interaction can lead to changes in cellular processes and may contribute to its therapeutic effects. However, it’s important to note that the exact mechanisms of DMSO’s actions are not fully understood and continue to be a subject of ongoing research.

FDA-Approved Uses of DMSO: Interstitial Cystitis Treatment

The most well-established and FDA-approved use of DMSO is in the treatment of interstitial cystitis, also known as painful bladder syndrome. This chronic condition causes pain and pressure in the bladder and pelvic area, often leading to significant discomfort and reduced quality of life for those affected.

How is DMSO used to treat interstitial cystitis?

In the treatment of interstitial cystitis, DMSO is typically administered as a bladder instillation. This procedure involves inserting a catheter into the bladder and filling it with a DMSO solution. The solution is left in place for a specified period before being drained. This treatment has shown efficacy in reducing pain and other symptoms associated with interstitial cystitis.

Clinical studies have demonstrated that regular bladder washes with DMSO can lead to significant improvements in pain levels and other symptoms for many patients with interstitial cystitis. However, it’s important to note that response to treatment can vary among individuals, and DMSO therapy should always be administered under the guidance of a healthcare professional.

Potential Benefits of DMSO in Pain Management

Beyond its approved use for interstitial cystitis, DMSO has shown promise in managing other types of pain, particularly in cases of complex regional pain syndrome (CRPS). This condition, also known as reflex sympathetic dystrophy, typically occurs after an injury and can cause severe, chronic pain in a limb.

Can DMSO help with complex regional pain syndrome?

Research suggests that topical application of DMSO cream may provide relief for individuals suffering from CRPS. The anti-inflammatory and analgesic properties of DMSO are thought to contribute to its pain-relieving effects. While more extensive studies are needed to fully establish its efficacy, preliminary results have been encouraging for many patients struggling with this challenging condition.

DMSO in Chemotherapy: Addressing Extravasation Concerns

One area where DMSO has shown potential benefit is in managing chemotherapy-related complications, specifically in cases of extravasation. Extravasation occurs when intravenous (IV) drugs, such as certain chemotherapy agents, leak from the vein into surrounding tissues, potentially causing severe damage.

How does DMSO help with chemotherapy extravasation?

When applied to the skin in cases of chemotherapy extravasation, DMSO may help prevent further tissue damage. Its ability to penetrate the skin and interact with the extravasated drug is thought to play a role in mitigating potential harm. However, it’s crucial to note that the use of DMSO in this context should only be done under strict medical supervision and in accordance with established protocols.

Exploring Other Potential Applications of DMSO

While DMSO has shown promise in several areas, many of its potential applications lack sufficient scientific evidence to support their efficacy. Nonetheless, researchers continue to explore its potential benefits in various conditions:

• Osteoarthritis: Some studies have investigated the use of topical DMSO for osteoarthritis pain relief, but results have been mixed.
• Pressure ulcers (bed sores): There’s interest in DMSO’s potential to promote wound healing in pressure ulcers, but more research is needed.
• Gastrointestinal disorders: Some preliminary research has looked at DMSO’s potential in treating certain gastrointestinal conditions, including stomach ulcers.

It’s important to approach these potential applications with caution, as more rigorous scientific studies are needed to establish their safety and efficacy.

Understanding the Side Effects and Risks of DMSO Use

While DMSO has shown therapeutic potential in certain applications, it’s not without risks and side effects. The safety profile of DMSO can vary depending on the route of administration and the specific formulation used.

What are the common side effects of topical DMSO application?

When applied to the skin, DMSO can cause:

• Skin irritation, including redness, itching, and burning sensation
• Dry, scaly skin
• A garlic-like taste or breath odor
• Allergic reactions in some individuals

It’s worth noting that the purity of the DMSO product used is crucial. Non-prescription or industrial-grade DMSO products may contain impurities that can lead to more severe side effects. Given DMSO’s ability to enhance absorption through the skin, these impurities can potentially enter the body and cause harm.

Are there systemic effects from DMSO use?

When DMSO is absorbed into the body, it can potentially cause systemic effects, including:

• Nausea and vomiting
• Headaches
• Dizziness
• Drowsiness
• Changes in blood pressure

In some cases, more severe reactions have been reported, particularly with high doses or prolonged use. These can include liver and kidney problems, although such occurrences are rare when DMSO is used as directed under medical supervision.

Precautions and Contraindications for DMSO Usage

Given the potential risks associated with DMSO use, several precautions and contraindications should be considered:

Who should avoid using DMSO?

DMSO may not be suitable for:

• Pregnant or breastfeeding women: Due to a lack of safety data, it’s generally recommended to avoid DMSO use during pregnancy and while breastfeeding.
• Individuals with certain blood disorders: DMSO may cause red blood cell breakdown, which could exacerbate certain blood conditions.
• People with kidney or liver problems: DMSO metabolism may put additional stress on these organs, potentially worsening existing conditions.
• Those with a history of allergic reactions to DMSO or similar compounds.

It’s crucial to consult with a healthcare provider before using DMSO, especially if you have any pre-existing medical conditions or are taking other medications.

Drug Interactions and DMSO: Important Considerations

DMSO’s ability to enhance absorption and its effects on various biological processes can lead to potential interactions with other medications. Understanding these interactions is crucial for safe use of DMSO.

How does DMSO interact with other medications?

Several important drug interactions have been identified:

• Increased drug absorption: When applied with other topical medications, DMSO can increase their absorption, potentially leading to increased effects and side effects.
• Blood thinners: DMSO may slow blood clotting, potentially increasing the risk of bruising and bleeding when used with anticoagulant medications.
• Pain medications: There’s some evidence that DMSO might reduce the effectiveness of certain pain medications, such as sulindac.
• Acetylcholinesterase inhibitors: DMSO can increase acetylcholine levels, potentially interacting with medications used for conditions like glaucoma and Alzheimer’s disease.
• Certain cancer treatments: DMSO might interfere with the effectiveness of some chemotherapy drugs, particularly platinum-based agents.

Given these potential interactions, it’s essential to inform your healthcare provider about all medications and supplements you’re taking before using DMSO.

Can DMSO affect laboratory test results?

DMSO use can potentially affect certain laboratory test results. This is particularly important for individuals undergoing regular medical monitoring. Some tests that may be affected include liver function tests and certain hormone assays. Always inform your healthcare provider and laboratory personnel about DMSO use before undergoing any medical tests.

Proper Usage and Dosing of DMSO

The appropriate use and dosing of DMSO can vary significantly depending on the specific application and formulation. It’s crucial to follow the guidance of a healthcare professional and adhere to prescribed dosages and application methods.

What are the common formulations of DMSO?

DMSO is available in several formulations, including:

• Topical solutions and gels (varying concentrations, typically 50-70%)
• Bladder instillation solutions (typically 50% concentration for interstitial cystitis treatment)
• Oral liquid (less common and should only be used under strict medical supervision)

The concentration and dosing schedule can vary based on the specific condition being treated and individual patient factors. For instance, in the treatment of interstitial cystitis, a typical regimen might involve bladder instillations with 50% DMSO solution every 1-2 weeks for 6-8 weeks, followed by maintenance treatments as needed.

How should DMSO be applied topically?

When using DMSO topically:

1. Clean and dry the application area thoroughly.
2. Apply the prescribed amount of DMSO to the affected area.
3. Gently massage the solution into the skin until it’s fully absorbed.
4. Wash your hands thoroughly after application.
5. Avoid covering the treated area with occlusive dressings unless directed by your healthcare provider.

It’s important to note that the skin may feel warm or experience a tingling sensation during and after application. This is normal, but if you experience severe burning or discomfort, rinse the area immediately and contact your healthcare provider.

The Future of DMSO Research and Potential Applications

While DMSO has been studied for decades, there’s still much to learn about its potential applications and long-term effects. Ongoing research continues to explore new possibilities for this versatile compound.

What are some promising areas of DMSO research?

Current and future research directions for DMSO include:

• Novel drug delivery systems: Exploiting DMSO’s ability to enhance absorption for improved medication delivery.
• Neuroprotective effects: Investigating DMSO’s potential to protect nerve cells from damage in conditions like stroke or traumatic brain injury.
• Anti-inflammatory applications: Further exploring DMSO’s anti-inflammatory properties for various conditions.
• Cryopreservation: Enhancing techniques for preserving biological samples and tissues.
• Combination therapies: Studying how DMSO might enhance the effects of other treatments in various medical fields.

As research progresses, our understanding of DMSO’s mechanisms of action and potential therapeutic applications continues to evolve. This ongoing work may lead to new approved uses and improved formulations in the future.

What challenges exist in DMSO research?

Despite its potential, DMSO research faces several challenges:

• Standardization: Ensuring consistent purity and concentration across different DMSO products and studies.
• Long-term safety: Gathering more data on the long-term effects of DMSO use, particularly for chronic conditions.
• Regulatory hurdles: Navigating the complex process of drug approval for new DMSO applications.
• Public perception: Addressing misconceptions and ensuring proper understanding of DMSO’s benefits and risks.

Overcoming these challenges will be crucial for realizing the full potential of DMSO in medical applications and ensuring its safe and effective use.

Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Dimethylsulfoxide (DMSO) is a chemical that dissolves many organic and inorganic substances. It’s available as a prescription drug and dietary supplement.

DMSO helps medicines get through the skin and can affect proteins, carbohydrates, fats, and water in the body.

People use DMSO for bladderinflammation (interstitial cystitis), limb pain that usually occurs after an injury, and leakage of an IV drug from the vein into surrounding skin and tissue. It is also used for osteoarthritis, bed sores, stomach ulcers, and many other conditions, but there is no good scientific evidence to support most of these other uses.

Don’t confuse DMSO with Methylsulfonylmethane (MSM). These are not the same.

Uses & Effectiveness ?

Effective for

• Painful bladder syndrome (interstitial cystitis). DMSO is an FDA-approved product for the treatment of this condition. Washing the bladder with DMSO improves some symptoms, such as pain.

Possibly Effective for

• Limb pain that usually occurs after an injury (complex regional pain syndrome). Applying DMSO cream to the skin seems to improve pain in people with this condition.
• Leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation). Some chemotherapy drugs can cause skin and tissue damage if they leak from the vein. Applying DMSO to the skin might prevent further damage if this happens.

Possibly Ineffective for

• Hardening of skin and connective tissue (scleroderma). Applying DMSO to the skin doesn’t help treat symptoms of scleroderma.

There is interest in using DMSO for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Special Precautions and Warnings

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Pregnancy and breast-feeding: There isn’t enough reliable information to know if DMSO is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Certain blood disorders. Injecting DMSO by IV might cause red blood cells to break down. This might be a problem for people with certain blood disorders. DMSO might make these conditions worse.

Kidney problems: DMSO might harm the kidneys. Check with a healthcare provider before using DMSO if you have kidney problems.

Liver problems: DMSO might harm the liver. Check with a healthcare provider before using DMSO if you have liver problems.br/>

Interactions ?

Moderate Interaction

Be cautious with this combination

• DMSO can sometimes increase how much medicine the body absorbs. Applying DMSO to the skin, eyes, or ears at the same time as applying medication can increase how much medicine the body absorbs. This might increase the effects and side effects of the medicine.

• DMSO might slow blood clotting. Taking DMSO along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

• Using DMSO with sulindac might reduce how well sulindac works to treat pain. There is also a concern that using DMSO with sulindac can increase the risk for nerve pain.

• DMSO can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking DMSO with these medications might increase the chance of side effects.

• Using DMSO with verteporfin might reduce how well verteporfin works.

• Using DMSO to dissolve platinum agents onto the skin might reduce how well these drugs work to treat cancer. Examples of platinum agents include carboplatin, cisplatin, and oxaliplatin.

Dosing

DMSO has most often been applied to the skin by adults in various forms, including creams, gels, and solutions. It is also applied inside the bladder. DMSO is available as a prescription and in dietary supplements. Speak with a healthcare provider before use.

View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

DMSO: Uses and Risks

Written by Joseph Saling

• Why Do People Use DMSO?
• What Are the Risks of Using DMSO?

DMSO, or dimethyl sulfoxide, is a by-product of paper making. It comes from a substance found in wood.

DMSO has been used as an industrial solvent since the mid-1800s. From about the mid-20th century, researchers have explored its use as an anti-inflammatory agent.

The FDA has approved DMSO as a prescription medication for treating symptoms of painful bladder syndrome. It’s also used under medical supervision to treat several other conditions, including shingles.

DMSO is easily absorbed by the skin. It’s sometimes used to increase the body’s absorption of other medications.

DMSO is available without a prescription most often in gel or cream form. It can be purchased in health food stores, by mail order, and on the Internet.

While it can sometimes be found as an oral supplement, its safety is unclear. DMSO is primarily used by applying it to the skin.

DMSO has been used to try to relieve the pain of osteoarthritis. It has also been promoted as an “alternative” cancer treatment.

People have used it to try to treat wounds, burns, and other injuries. People have also used it to try to treat such conditions as:

• Headache
• Rheumatoid arthritis
• Eye problems
• Scars
• Scleroderma (disease that causes scar tissue to form in the skin)

Other than its use as a prescription medicine, there is little or no scientific evidence to support other claims made about DMSO’s effectiveness.

The American Cancer Society says there is no evidence to support the use of DMSO to treat cancer. Using it that way could cause serious delays in getting proper and effective treatment.

A recent analysis of studies on the use of DMSO to relieve osteoarthritis pain found that it was not significantly more effective than placebo in relieving joint pain.

There are no studies that provide guidelines for determining the proper dose of DMSO. The gel used to treat osteoarthritis typically has a concentration of 25%. It is applied three or four times a day. But DMSO sold without a prescription can range from 10% concentration to 90%.

Some DMSO on the market may actually be industrial grade. Industrial grade DMSO may contain a number of impurities that can easily be absorbed into the skin with potentially serious health effects.

The most frequent side effects from using DMSO on the skin include:

• Stomach upset
• Skin irritation
• Strong odor of garlic

More serious side effects include:

• Severe allergic reactions
• Headaches
• Itching and burning when applied to the skin

DMSO can also cause a deadly reaction when used in high concentrations.

Using DMSO by mouth can cause:

• Dizziness
• Drowsiness
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Decreased appetite

DMSO can increase the effect of some medicines, which can lead to serious health issues. Examples of such medicines include:

• Blood thinners
• Steroids
• Sedatives

The biggest concern of DMSO as a solvent is that when it gets on the skin it will cause anything on the skin to be absorbed. So be sure to wash your hands and skin well before using.

Pregnant women and women who are breastfeeding should not use DMSO, since little is known about its possible effects on the fetus or infant.

You should also not use DMSO without talking to your doctor if you have:

• Diabetes
• Asthma
• Liver and kidney conditions

Always keep in mind that supplements are not regulated by the FDA the same was as drugs are. The manufacturer does not have to prove that a supplement is safe or effective before selling.

Top Picks

Dimethyl Sulfoxide | Memorial Sloan Kettering Cancer Center

Adult Medication

Share

Provided by Lexicomp ^® , this document contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Rimso-50

Trade names: Canada

Rimso-50

What is this drug used for?

• It is used to relieve pain, reduce inflammation and reduce bladder irritation.
• If you have been taking this drug for any other reason, ask your doctor about the benefits and risks. If you have questions or concerns about using this drug, talk with your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.

Combining this drug with certain drugs and conditions may be unfavorable.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Get a blood test and an eye exam as directed by your doctor.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Vision changes, eye pain or severe eye irritation.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Irritation at the site of application of the drug.
• When taking this drug, the skin and breath acquired a smell reminiscent of garlic. The odor may persist for up to 72 hours after using this drug.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

• The drug is injected through a catheter into the bladder.
• You need to urinate after taking this drug. This helps to remove the drug from the bladder. Drink large amounts of decaffeinated fluids during or immediately after taking this drug, unless your doctor tells you otherwise. Continue drinking fluids as directed by your doctor.

What if I miss a dose of a drug?

• See your doctor for further instructions.

How do I store and/or discard this drug?

• If you need to store this drug at home, check with your doctor, nurse, or pharmacist for storage conditions.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.
• Some medicines may come with other patient information leaflets. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www. wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2021-06-25

Copyright

© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

Description DIMETHYL SULFOXIDE indications, dosages, contraindications of the active substance DIMETHYL SULFOXIDE

Rec.INN registered by WHO Included in preparations: list Pharmacological action Anti-inflammatory agent for external use. The mechanism of action is associated with the inactivation of hydroxyl radicals and the improvement of metabolic processes in the focus of inflammation, a decrease in the rate of conduction of excitatory impulses in peripheral neurons. It has a local anesthetic, local anti-inflammatory, analgesic and antimicrobial effect; has some fibrinolytic activity. Penetrates through the skin and other biological membranes, increases their permeability to drugs. Pharmacokinetics When a solution of dimethyl sulfoxide is applied to the skin, it is detected in the blood after 5 minutes, C max is reached after 4-6 hours, maintaining an almost unchanged level for 1.5-3 days. Dimethyl sulfoxide is excreted in the urine and feces, both unchanged and as dimethyl sulfone. Indications of the active substance DIMETHYLSULPHOXIDE As part of complex therapy: diseases of the musculoskeletal system: rheumatoid arthritis, ankylosing spondylitis (Bekhterev’s disease), deforming osteoarthrosis (in the presence of damage to periarticular tissues), reactive synovitis, limited scleroderma, erythema nodosum, discoid lupus erythematosus, mycosis of the feet, keloid scars, thrombophlebitis, alopecia, eczema, streptoderma, erysipelas; bruises, sprains, traumatic infiltrates; purulent wounds, burns, sciatica, trophic ulcers, acne, furunculosis; in skin plastic surgery – for preservation of skin homotransplants. Open list of ICD-10 codes A46 erysipelas B35.3 Foot mycosis I80 Phlebitis and thrombophlebitis L02 Skin abscess, furuncle and carbuncle L08.0 Pyoderma L20.8 Other atopic dermatitis (neurodermatitis, eczema) L30.0 Coin-shaped eczema L52 Erythema nodosum L63.9 Alopecia areata, unspecified L64. 9 Androgenetic alopecia, unspecified L70 Acne L91.0 Hypertrophic scar L93.0 Discoid lupus erythematosus L94.0 Localized scleroderma [morphea] L98.4 Chronic skin ulcer, not elsewhere classified M05 Seropositive rheumatoid arthritis M15 Polyarthrosis M45 Ankylosing spondylitis M54.1 Radiculopathy M54. 3 Sciatica M54.4 Lumbago with sciatica M65 Synovitis and tenosynovitis T14.0 Superficial injury of an unspecified area of ​​the body (incl. abrasion, bruising, contusion, hematoma, non-venomous insect bite) T14.3 Dislocation, sprain and strain of the capsular-ligamentous apparatus of the joint of an unspecified area of ​​the body T30 Thermal and chemical burns, unspecified T79.3 Post-traumatic wound infection, not elsewhere classified Dosing regimen Apply externally. In the form of applications and irrigations (washings). The concentration of the solution and the solvent is determined depending on the application. The duration of treatment is 10-15 days. Side effects Possible: allergic reactions, pruritic dermatitis, contact dermatitis, erythema, dry skin, mild burning, pruritic dermatitis. Rare: bronchospasm. Contraindications for use Hypersensitivity to dimethyl sulfoxide; severe hepatic and / or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataracts, stroke, coma, myocardial infarction; pregnancy; breastfeeding period; children’s age up to 12 years. Use in pregnancy and lactation Dimethyl sulfoxide is contraindicated in pregnancy and lactation. Use in hepatic impairment Contraindicated in severe hepatic impairment. Use in impaired renal function Contraindicated in severe renal impairment. Use in children Use in children under 12 years of age is contraindicated. Leave a Reply Cancel reply Your email address will not be published. Required fields are marked * Comment * Name * Email * Website