What are the potential benefits and risks of using DMSO for arthritis. How does DMSO work as a treatment. Is DMSO FDA-approved for arthritis. What are the common side effects of DMSO.

Understanding DMSO: Origins and Medical Potential

Dimethyl sulfoxide (DMSO) is a clear, odorless liquid that has gained attention in recent years for its potential medical applications. Originally a byproduct of the paper-making process, DMSO was primarily used as an industrial solvent. However, in the 1960s, scientists discovered its unique ability to penetrate biological membranes rapidly, opening up new possibilities in medicine.

DMSO’s most notable characteristic is its capacity to facilitate the absorption of other substances through the skin. This property has led researchers to explore its potential as a delivery mechanism for topical medications. Additionally, some studies suggest that DMSO itself may possess anti-inflammatory and pain-reducing properties, sparking interest in its use for various medical conditions, including arthritis.

DMSO and Arthritis: Examining the Claims

Despite growing commercial interest in DMSO as an arthritis treatment, it’s crucial to understand that the Food and Drug Administration (FDA) has not approved DMSO or any DMSO-derived products for this purpose. The only FDA-approved use for DMSO is in the treatment of interstitial cystitis, a chronic bladder condition.

Why has DMSO gained popularity for arthritis treatment? The answer lies in its purported anti-inflammatory properties. Some proponents claim that DMSO can help reduce pain and inflammation associated with arthritis. However, it’s important to note that these claims are largely anecdotal and lack substantial scientific backing.

Current Research on DMSO for Arthritis

While some research suggests that DMSO may have potential in managing arthritis symptoms, the current evidence is limited and inconclusive. Most studies have been small-scale or have produced mixed results, making it difficult to draw definitive conclusions about DMSO’s efficacy for arthritis.

Are there any ongoing clinical trials investigating DMSO for arthritis? Several small-scale studies are exploring DMSO’s potential, but large, well-designed clinical trials are still lacking. This gap in research underscores the need for caution when considering DMSO as an arthritis treatment.

Potential Risks and Side Effects of DMSO Use

Understanding the potential risks associated with DMSO use is crucial for anyone considering it as a treatment option. A comprehensive review of 109 studies reporting adverse effects of DMSO in humans revealed several common side effects:

• Gastrointestinal symptoms (halitosis, abdominal aches, nausea, vomiting, diarrhea)
• Dermatological reactions (rashes, itching, scaling, blistering)
• Rare cardiac and neurological reactions

The severity and frequency of side effects appear to be dose-dependent, with lower doses generally associated with milder or no side effects. The method of administration also plays a role in the type of side effects experienced. For instance, cardiac reactions were only reported with intravenous administration, while skin reactions were more common with topical use.

DMSO Interactions with Other Medications

One of the significant concerns with DMSO use is its potential to interact with other medications. Due to its ability to enhance skin absorption, DMSO could potentially increase the uptake of other topical medications to dangerous levels. This interaction potential underscores the importance of consulting with a healthcare provider before using DMSO, especially for individuals taking other medications.

Approved Medical Uses of DMSO

While DMSO has garnered attention for various potential applications, its FDA-approved uses remain limited. Currently, the only FDA-approved use for DMSO is in the treatment of interstitial cystitis. This approval is specifically for intravesical administration, where the medication is delivered directly into the bladder.

How is DMSO typically administered in medical settings? The most common methods of DMSO administration are topical (as a gel or solution) and intravesical. Other methods, such as oral and intravenous administration, have been explored in research settings, but their safety and efficacy are not well-established.

DMSO in Cancer Treatment: Potential and Precautions

The role of DMSO in cancer treatment is a subject of ongoing research and debate. Some studies suggest that DMSO may help alleviate certain side effects of chemotherapy, such as skin and tissue damage. However, the use of DMSO in cancer treatment is complex and not without risks.

Can DMSO interfere with chemotherapy drugs? Research has shown that DMSO can potentially interfere with certain chemotherapy drugs, including cisplatin, carboplatin, and oxaliplatin. This interaction could potentially reduce the effectiveness of these treatments.

On the other hand, some recent studies have indicated that DMSO might have anti-cancer properties of its own. A 2020 study suggested that DMSO may inhibit cancer cell growth and promote cancer cell death. However, these findings are preliminary and require further investigation.

FDA-Approved DMSO-Based Cancer Treatment

While DMSO itself is not approved for cancer treatment, the FDA has approved a combination drug called trametinib dimethyl sulfoxide for treating certain types of cancer, including anaplastic thyroid cancer, melanoma, and non-small cell lung cancer. However, this treatment is only recommended for patients who meet specific criteria.

Legal and Regulatory Status of DMSO

The regulatory status of DMSO varies depending on its intended use and the country in question. In the United States, DMSO is FDA-approved only for the treatment of interstitial cystitis. Its use for other medical conditions, including arthritis, is considered off-label and not regulated by the FDA.

How does the legal status of DMSO affect its availability? While DMSO is available over-the-counter in some countries, its sale and use for medical purposes in the U.S. are restricted to FDA-approved applications. However, DMSO is still widely available for industrial and research purposes.

The Future of DMSO Research

Despite the current limitations in DMSO’s approved medical uses, research into its potential applications continues. Scientists are exploring DMSO’s properties as a cryoprotectant, its potential in drug delivery systems, and its possible anti-inflammatory and analgesic effects.

What areas of DMSO research show the most promise? Some of the most intriguing areas of current DMSO research include:

1. Its potential as a vehicle for transdermal drug delivery
2. Its use in cryopreservation of biological materials
3. Its possible neuroprotective effects in certain neurological conditions
4. Its potential anti-inflammatory properties in various diseases

While these areas of research are exciting, it’s important to note that much of this work is still in preliminary stages. Large-scale clinical trials are needed to establish the safety and efficacy of DMSO for these potential applications.

Alternatives to DMSO for Arthritis Treatment

Given the lack of FDA approval and limited scientific evidence supporting DMSO use for arthritis, individuals suffering from this condition may want to explore other treatment options. There are numerous FDA-approved treatments for arthritis that have been proven safe and effective through rigorous clinical trials.

What are some FDA-approved treatments for arthritis? Some common treatments include:

• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Disease-modifying antirheumatic drugs (DMARDs)
• Corticosteroids
• Biologic response modifiers
• Physical therapy and exercise
• Weight management
• Surgical interventions in severe cases

These treatments can be used individually or in combination, depending on the type and severity of arthritis. It’s crucial for individuals with arthritis to work closely with their healthcare providers to develop a comprehensive treatment plan tailored to their specific needs.

Complementary and Alternative Therapies for Arthritis

In addition to conventional treatments, some individuals with arthritis explore complementary and alternative therapies. While these approaches may not have the same level of scientific evidence as FDA-approved treatments, some people find them helpful in managing their symptoms.

What are some popular complementary therapies for arthritis? Some commonly used complementary approaches include:

• Acupuncture
• Massage therapy
• Yoga and tai chi
• Dietary supplements (e.g., glucosamine, chondroitin)
• Herbal remedies
• Mind-body techniques (e.g., meditation, relaxation therapy)

It’s important to note that while some people may find these therapies beneficial, their effectiveness can vary widely between individuals. Always consult with a healthcare provider before starting any new treatment, including complementary therapies.

The Importance of Evidence-Based Medicine in Arthritis Treatment

The case of DMSO and its purported benefits for arthritis highlight the crucial importance of evidence-based medicine in healthcare decision-making. While anecdotal reports and preliminary studies can provide valuable insights and directions for future research, they cannot replace the rigorous testing and validation required for medical treatments.

Why is evidence-based medicine so important in arthritis treatment? Evidence-based medicine ensures that treatments are:

1. Safe: Thoroughly tested to minimize risks and side effects
2. Effective: Proven to work through well-designed clinical trials
3. Consistent: Reliably produce the intended effects across diverse patient populations
4. Transparent: Open to scrutiny and peer review by the scientific community

For individuals living with arthritis, relying on evidence-based treatments offers the best chance of managing symptoms effectively and safely. While the allure of alternative treatments like DMSO can be strong, especially for those struggling with chronic pain, it’s crucial to approach such options with caution and skepticism.

The Role of Clinical Trials in Arthritis Research

Clinical trials play a pivotal role in advancing our understanding and treatment of arthritis. These carefully designed studies allow researchers to test new treatments, compare different therapies, and identify potential side effects in a controlled and monitored environment.

How do clinical trials contribute to arthritis treatment? Clinical trials:

• Evaluate the safety and efficacy of new drugs and therapies
• Compare new treatments to existing standard-of-care options
• Identify optimal dosing and administration methods
• Assess long-term effects and potential risks
• Explore treatments for different types and stages of arthritis

For those interested in contributing to arthritis research or accessing cutting-edge treatments, participating in clinical trials can be an option worth exploring. However, it’s important to thoroughly understand the potential risks and benefits before enrolling in any study.

The Future of Arthritis Treatment: Beyond DMSO

While DMSO may not have lived up to its initial promise as an arthritis treatment, the field of rheumatology continues to advance rapidly. Researchers are exploring numerous innovative approaches to managing and potentially curing various forms of arthritis.

What are some promising areas of arthritis research? Some exciting developments include:

1. Targeted biologics: Medications that precisely target specific components of the immune system involved in arthritis
2. Gene therapy: Approaches that aim to correct genetic factors contributing to arthritis
3. Stem cell therapy: Using stem cells to regenerate damaged cartilage and joints
4. Nanotechnology: Developing nanoscale drug delivery systems for more effective and targeted treatments
5. Personalized medicine: Tailoring treatments based on an individual’s genetic profile and specific disease characteristics

These emerging technologies and approaches hold the potential to revolutionize arthritis treatment in the coming years, offering hope for improved outcomes and quality of life for those affected by this challenging condition.

The Role of Patient Advocacy in Arthritis Research

Patient advocacy groups play a crucial role in advancing arthritis research and treatment. These organizations work to raise awareness, fund research, and advocate for policies that support individuals living with arthritis.

How do patient advocacy groups contribute to arthritis research and treatment? They often:

• Fund research grants and fellowships
• Facilitate patient participation in clinical trials
• Provide educational resources for patients and healthcare providers
• Advocate for increased research funding and improved access to treatments
• Offer support services for individuals living with arthritis

By engaging with patient advocacy groups, individuals with arthritis can not only access valuable resources and support but also contribute to the broader effort to improve arthritis care and research.

Navigating Arthritis Treatment Options: A Personalized Approach

Given the complexity of arthritis and the wide array of treatment options available, developing an effective management plan often requires a personalized approach. What works well for one individual may not be as effective for another, highlighting the importance of working closely with healthcare providers to find the right combination of treatments.

How can individuals with arthritis navigate their treatment options effectively? Consider the following steps:

1. Educate yourself: Learn about your specific type of arthritis and the available treatment options
2. Communicate openly with your healthcare team: Share your symptoms, concerns, and treatment goals
3. Consider a multidisciplinary approach: Work with various specialists (e.g., rheumatologists, physical therapists, nutritionists) for comprehensive care
4. Be patient and persistent: Finding the right treatment regimen may take time and require adjustments
5. Stay informed about new developments: Keep abreast of the latest research and treatment options
6. Prioritize overall health: Incorporate lifestyle changes that support joint health and overall well-being

By taking an active role in their treatment journey and working collaboratively with healthcare providers, individuals with arthritis can optimize their chances of achieving the best possible outcomes.

The Importance of Early Intervention in Arthritis

One of the key lessons from decades of arthritis research is the critical importance of early intervention. Prompt diagnosis and treatment can significantly impact the course of the disease, potentially slowing its progression and minimizing joint damage.

Why is early intervention so crucial in arthritis treatment? Early intervention can:

• Prevent or slow joint damage
• Reduce pain and inflammation
• Preserve joint function and mobility
• Improve long-term outcomes and quality of life
• Potentially reduce the need for more aggressive treatments later on

Recognizing the early signs of arthritis and seeking prompt medical attention can make a significant difference in the long-term management of the condition. This underscores the importance of regular check-ups and open communication with healthcare providers about any new or changing joint symptoms.

DMSO benefits, uses, risks, and more

While there are many arthritis treatments available, not all medications that companies market to treat the condition have approval for that purpose. One of these is dimethyl sulfoxide (DMSO).

DMSO is a clear, odorless liquid that easily penetrates the skin and other organic membranes.

It is gaining commercial traction as a potential treatment for arthritis symptoms, mostly due to its ability to reduce pain and inflammation. However, it does not have approval as an arthritis treatment.

Despite anecdotal claims of its benefits, using DMSO for arthritis, especially as an over-the-counter treatment, could be dangerous.

Read more to learn about the medical uses for DMSO, how it works, its risks and benefits, and more.

DMSO is a byproduct of the paper-making process. Originally, manufacturers used it primarily as an industrial solvent.

In the 1960s, scientists realized that DMSO could act as a way to administer topical medications. Because biological membranes can rapidly absorb DMSO, the substance can help the skin absorb medicines. It may also have pain and inflammation-reducing properties.

Probably due to its purported anti-inflammatory properties, DMSO has gained some commercial popularity as a treatment for arthritis. Some people claim that DMSO may help reduce pain and inflammation associated with the condition.

However, the Food and Drug Administration (FDA) has not approved DMSO, or any medication that includes DMSO-derived ingredients, to treat arthritis. It only has FDA approval to treat interstitial cystitis, a condition causing bladder pain.

While some research on DMSO for arthritis management may warrant further investigation, the current evidence is anecdotal rather than scientific.

With this in mind, people interested in trying DMSO for arthritis should speak with a doctor first.

In a 2018 review, researchers looked at 109 studies that reported harmful side effects of DMSO in humans. They found that most negative reactions were either short term or rare.

Some of the most common reported adverse reactions were gastrointestinal symptoms, such as halitosis, abdominal aches, stomach cramps, nausea, vomiting, and diarrhea. Other common reactions included dermatological skin reactions, such as rashes, itching, scaling, blistering, and pigmentation increases. There were also rare side effects that included cardiac and neurological reactions.

Additionally, the research indicated that side effects may have links to its administration method. For example, cardiac reactions only occurred when healthcare professionals administered DMSO intravenously, and skin reactions were more likely to develop following topical applications.

Furthermore, researchers found a connection between the dose size and reactions. People who took low doses reported no or mild side effects.

DMSO may also negatively interact with other medications. For example, because DMSO easily absorbs into the skin, using it with other topical medications could dangerously increase the amount of medication the body receives.

People interested in using DMSO for arthritis should contact a doctor before trying it or starting any new medication.

People should only use DMSO when a doctor prescribes it. The most common ways of use are topical, such as a gel or other solution, or intravesically, which involves going through the bladder.

Other methods include oral and intravenous. However, there is not enough research to determine their safety.

DMSO is also in common use as a chemical solvent in scientific and industrial communities. Medically, the only FDA-approved use for DMSO is as a treatment for interstitial cystitis, a chronic and often painful bladder condition.

There is still insufficient scientific evidence proving DMSO is both a safe and effective alternative treatment for these and other conditions.

Cancer and DMSO

While some people may experience relief from certain chemotherapy side effects, such as skin and tissue damage, using DMSO as an alternative treatment for cancer can carry risks. For example, a 2014 study explains how DMSO can interfere with chemotherapy drugs such as cisplatin, carboplatin, and oxaliplatin.

Conversely, a more recent 2020 study shows DMSO may prevent the growth of and encourage the death of cancer cells.

Furthermore, the FDA has approved trametinib dimethyl sulfoxide — a combination of trametinib and dimethyl sulfoxide — for treating anaplastic thyroid cancer, melanoma, and nonsmall cell lung cancer. However, doctors only recommend the treatment if a person and the cancer they have meet certain criteria.

At present, DMSO only has FDA approval to treat interstitial cystitis. While there is some anecdotal evidence that DMSO may alleviate the pain and inflammation associated with arthritis, there is no scientific evidence proving its efficacy.

A person interested in using DMSO for arthritis should contact a doctor.

DMSO benefits, uses, risks, and more

While there are many arthritis treatments available, not all medications that companies market to treat the condition have approval for that purpose. One of these is dimethyl sulfoxide (DMSO).

DMSO is a clear, odorless liquid that easily penetrates the skin and other organic membranes.

It is gaining commercial traction as a potential treatment for arthritis symptoms, mostly due to its ability to reduce pain and inflammation. However, it does not have approval as an arthritis treatment.

Despite anecdotal claims of its benefits, using DMSO for arthritis, especially as an over-the-counter treatment, could be dangerous.

Read more to learn about the medical uses for DMSO, how it works, its risks and benefits, and more.

DMSO is a byproduct of the paper-making process. Originally, manufacturers used it primarily as an industrial solvent.

In the 1960s, scientists realized that DMSO could act as a way to administer topical medications. Because biological membranes can rapidly absorb DMSO, the substance can help the skin absorb medicines. It may also have pain and inflammation-reducing properties.

Probably due to its purported anti-inflammatory properties, DMSO has gained some commercial popularity as a treatment for arthritis. Some people claim that DMSO may help reduce pain and inflammation associated with the condition.

However, the Food and Drug Administration (FDA) has not approved DMSO, or any medication that includes DMSO-derived ingredients, to treat arthritis. It only has FDA approval to treat interstitial cystitis, a condition causing bladder pain.

While some research on DMSO for arthritis management may warrant further investigation, the current evidence is anecdotal rather than scientific.

With this in mind, people interested in trying DMSO for arthritis should speak with a doctor first.

In a 2018 review, researchers looked at 109 studies that reported harmful side effects of DMSO in humans. They found that most negative reactions were either short term or rare.

Some of the most common reported adverse reactions were gastrointestinal symptoms, such as halitosis, abdominal aches, stomach cramps, nausea, vomiting, and diarrhea. Other common reactions included dermatological skin reactions, such as rashes, itching, scaling, blistering, and pigmentation increases. There were also rare side effects that included cardiac and neurological reactions.

Additionally, the research indicated that side effects may have links to its administration method. For example, cardiac reactions only occurred when healthcare professionals administered DMSO intravenously, and skin reactions were more likely to develop following topical applications.

Furthermore, researchers found a connection between the dose size and reactions. People who took low doses reported no or mild side effects.

DMSO may also negatively interact with other medications. For example, because DMSO easily absorbs into the skin, using it with other topical medications could dangerously increase the amount of medication the body receives.

People interested in using DMSO for arthritis should contact a doctor before trying it or starting any new medication.

People should only use DMSO when a doctor prescribes it. The most common ways of use are topical, such as a gel or other solution, or intravesically, which involves going through the bladder.

Other methods include oral and intravenous. However, there is not enough research to determine their safety.

DMSO is also in common use as a chemical solvent in scientific and industrial communities. Medically, the only FDA-approved use for DMSO is as a treatment for interstitial cystitis, a chronic and often painful bladder condition.

There is still insufficient scientific evidence proving DMSO is both a safe and effective alternative treatment for these and other conditions.

Cancer and DMSO

While some people may experience relief from certain chemotherapy side effects, such as skin and tissue damage, using DMSO as an alternative treatment for cancer can carry risks. For example, a 2014 study explains how DMSO can interfere with chemotherapy drugs such as cisplatin, carboplatin, and oxaliplatin.

Conversely, a more recent 2020 study shows DMSO may prevent the growth of and encourage the death of cancer cells.

Furthermore, the FDA has approved trametinib dimethyl sulfoxide — a combination of trametinib and dimethyl sulfoxide — for treating anaplastic thyroid cancer, melanoma, and nonsmall cell lung cancer. However, doctors only recommend the treatment if a person and the cancer they have meet certain criteria.

At present, DMSO only has FDA approval to treat interstitial cystitis. While there is some anecdotal evidence that DMSO may alleviate the pain and inflammation associated with arthritis, there is no scientific evidence proving its efficacy.

A person interested in using DMSO for arthritis should contact a doctor.

Scientists have found a way to destroy the toxic “eternal chemicals” that flooded the world – Gazeta.Ru

Scientists have found a way to destroy the toxic “eternal chemicals” that flooded the world – Gazeta.Ru | News

August 20, 2022, 19:03

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Researchers have shown that a mixture of soap and DMSO solvent can break down per- and polyfluoroalkyl compounds (PFAS), known as “timeless chemicals”. Development reported Science .

Two years ago, researchers from the US Environmental Protection Agency placed a sample of PFAS in a common solvent (DMSO) to study toxicity, but the substance began to degrade. The new study builds on this observation. Scientists from Northwestern University studied various mixtures containing DMSO. The mixture of DMSO and sodium hydroxide, a common soap ingredient, showed the greatest effectiveness when heated to boiling point.

This method works with approximately 40% PFAS. Now it has to be tested on large volumes. Those compounds, the destruction of which chemists have studied, are used in fire-fighting foams and the production of non-stick coatings.

PFAS are known as “timeless chemicals” because they can remain in the environment for decades. Recently, they have even been found in rainwater in the Tibetan Plateau in quantities far exceeding safe ones. The new method will cheaply and safely cleanse the planet of potentially toxic and carcinogenic substances.

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DMSO (dimethyl sulfoxide) in the best quality pharmaceutical premium

DMSO – Universal Solvent (100 ml)

Dimethyl Sulfoxide (DMSO) is a colorless and odorless organic universal solvent used in laboratory and technical applications. Very high purity of 99.9% meets Ph.Eur certification. Depending on the application, it is easily mixed with water in any ratio. It has an amazing amount of good properties and is extremely versatile.

Benefits of using DMSO:

• Pharmaceutical purity according to the European Pharmacopoeia

• Integrated dropper for easy dosing

• TÜV Rheinland tested: 100% EU-compliant

• Filled in break-proof and child-proof HDPE bottle

• is perfect for travel, outdoor or crisis preparedness!

• The original, only from AQUARIUS pro life

Disadvantages compared to other DMSO solutions:

• often no pharmaceutical safety

• No TÜV-tested EU conformity

• Often bottled in fragile glass bottles

• is therefore impractical for travel and outdoor use.

Benefits of using DMSO:

• Pharmaceutical purity according to the European Pharmacopoeia

• Integrated dropper for easy dosing

• TÜV Rheinland tested: 100% EU-compliant

• Filled in break-proof and child-proof HDPE bottle

• is perfect for travel, outdoor or crisis preparedness!

• The original, only from AQUARIUS pro life

Disadvantages compared to other DMSO solutions:

• often no pharmaceutical safety

• No TÜV-tested EU conformity

• Often bottled in fragile glass bottles

• is therefore impractical for travel and outdoor use.

Content:

100ml 99.9% DMSO ultrapure Ph.Eur in HDPE bottle

(CAS no: 67-68-5, EC no: 200-664-3) Taric: 29091990

Storage and shelf life:

Store in a dry place at room temperature, well closed and out of the reach of children!

DMSO becomes crystalline and solid at low temperatures below 18°C, eg during transport or in winter. This is completely normal and harmless. When heated in a warm water bath, it becomes liquid again. Remove residues on fabrics and surfaces immediately with a damp cloth. DMSO is a long-term stable compound and therefore has a very long shelf life.

Areas of use:

Depending on the application, DMSO can be easily mixed with water in any ratio. Dimethyl sulfoxide has an amazing amount of good properties and is extremely versatile, being used in cosmetics, pharmaceuticals, and as a widely used solvent in laboratories and engineering, among others.

Environment protection:

The raw materials for our sustainable packaging and product information sheet come from sustainable forestry (FSC) and are printed in a climate-neutral way. Please recycle them. Our bottles, child-resistant cap and label are made from polyethylene and are recyclable.

Important note:

Use solvents safely! Always read the label and product information before use.

Keep out of reach of children.

“Glass or HDPE bottle – which is better?”.

Many suppliers use amber glass bottles and advertise that they are much safer and better protect the contents from, for example, UV rays or soluble plastic. However, the fact is that this ingredient is not sensitive to either light or UV, and HDPE (High Density Polyethylene) is a legally approved and suitable storage material. Every industrial manufacturer of DMSO produces, bottles and stores it in HDPE cans, drums or containers.

How can quality be improved by pouring into glass bottles?

Conclusion: HDPE is a legal plastic for storing DMSO and does not mix with the filler in any way. Precise drip filling is much easier with our unbreakable HDPE bottle.

That’s why we only use approved HDPE and not glass – for your safety!

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