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Does dmso work. DMSO for Arthritis: Benefits, Uses, Risks, and Medical Applications

by alexxlab

What are the potential benefits of DMSO for arthritis. How does DMSO work in the body. What are the risks and side effects of using DMSO. Is DMSO FDA-approved for treating arthritis. What are the medical uses of DMSO.

Understanding DMSO: Origins and Properties

Dimethyl sulfoxide (DMSO) is a clear, odorless liquid that has gained attention in recent years for its potential medical applications. Originally a byproduct of the paper-making process, DMSO was primarily used as an industrial solvent. However, in the 1960s, scientists discovered its unique ability to penetrate biological membranes rapidly, opening up new possibilities in the medical field.

DMSO’s key properties include:

  • High permeability through organic membranes
  • Potential anti-inflammatory properties
  • Ability to enhance the absorption of other substances

These characteristics have led to growing interest in DMSO as a potential treatment for various conditions, including arthritis. However, it’s crucial to understand that while DMSO shows promise, its use for many medical applications remains controversial and largely unproven.

DMSO and Arthritis: Exploring the Connection

The potential use of DMSO for arthritis has garnered significant attention, particularly due to its purported anti-inflammatory and pain-reducing properties. Many individuals claim that DMSO helps alleviate arthritis symptoms, leading to its increased commercial popularity as an alternative treatment.

Can DMSO effectively treat arthritis symptoms? While anecdotal evidence suggests potential benefits, it’s important to note that the Food and Drug Administration (FDA) has not approved DMSO or any DMSO-derived ingredients for arthritis treatment. The current evidence supporting its use for this purpose is largely anecdotal rather than scientific.

Despite the lack of FDA approval, some researchers believe that DMSO’s potential for arthritis management warrants further investigation. However, individuals considering DMSO for arthritis should always consult with a healthcare professional before trying it, as its use without proper medical supervision could be dangerous.

FDA-Approved Uses of DMSO

While DMSO has gained popularity for various off-label uses, it’s crucial to understand its current FDA-approved applications. As of now, the FDA has only approved DMSO for one specific medical use: the treatment of interstitial cystitis.

Interstitial cystitis is a chronic condition characterized by bladder pain and discomfort. DMSO’s ability to penetrate biological membranes makes it an effective treatment option for this condition when administered intravesically (through the bladder).

Why has the FDA only approved DMSO for this specific use? The approval process for medications is rigorous and requires substantial scientific evidence demonstrating both safety and efficacy. While DMSO shows potential for other applications, including arthritis treatment, the current body of research does not meet the FDA’s stringent criteria for approval in these areas.

Potential Benefits and Mechanisms of Action

Despite the lack of FDA approval for arthritis treatment, DMSO has several properties that make it interesting to researchers and individuals seeking alternative therapies:

  1. Anti-inflammatory effects: DMSO may help reduce inflammation in the body, which could potentially alleviate arthritis symptoms.
  2. Pain reduction: Some users report decreased pain levels when using DMSO topically.
  3. Enhanced absorption: DMSO’s ability to penetrate the skin easily may help other medications absorb more effectively when used in combination.
  4. Antioxidant properties: Some studies suggest DMSO may have antioxidant effects, potentially protecting cells from damage.

How does DMSO work in the body to produce these effects? The exact mechanisms are not fully understood, but researchers believe that DMSO’s unique chemical structure allows it to interact with various biological processes. Its ability to easily cross cell membranes may play a crucial role in its potential therapeutic effects.

Risks and Side Effects of DMSO Use

While DMSO has potential benefits, it’s essential to consider the risks and side effects associated with its use. A comprehensive review of 109 studies reporting harmful side effects of DMSO in humans revealed several important findings:

Common Side Effects

  • Gastrointestinal symptoms: Halitosis, abdominal aches, stomach cramps, nausea, vomiting, and diarrhea
  • Dermatological reactions: Rashes, itching, scaling, blistering, and increased skin pigmentation

Rare Side Effects

  • Cardiac reactions (observed only with intravenous administration)
  • Neurological reactions

The severity and occurrence of side effects appear to be dose-dependent, with low doses generally resulting in no or mild side effects. Additionally, the method of administration may influence the likelihood of certain reactions. For example, skin reactions were more common with topical applications, while cardiac reactions were only observed with intravenous use.

Are there any long-term risks associated with DMSO use? Most reported negative reactions were either short-term or rare. However, the long-term effects of prolonged DMSO use, especially for off-label purposes like arthritis treatment, are not well-established and require further research.

Drug Interactions and Precautions

One of the most significant concerns regarding DMSO use is its potential for drug interactions. Due to its high permeability, DMSO can enhance the absorption of other substances, including medications. This property can lead to unintended and potentially dangerous increases in medication levels in the body.

What precautions should individuals take when considering DMSO use?

  • Always consult with a healthcare professional before using DMSO, especially if you’re taking other medications.
  • Avoid using DMSO with other topical medications unless specifically advised by a doctor.
  • Be cautious about using DMSO products from unregulated sources, as their purity and concentration may vary.
  • Report any unusual symptoms or side effects to your healthcare provider immediately.

It’s crucial to remember that DMSO should only be used under medical supervision and for FDA-approved purposes. Self-administration for conditions like arthritis carries significant risks and is not recommended.

DMSO in Cancer Treatment: A Complex Picture

The potential role of DMSO in cancer treatment is a subject of ongoing research and debate. While some studies suggest potential benefits, others highlight significant risks and complications.

Potential Benefits

Some cancer patients report relief from certain chemotherapy side effects, such as skin and tissue damage, when using DMSO. Additionally, a 2020 study indicated that DMSO might have anti-cancer properties, potentially preventing the growth of cancer cells and encouraging their death.

Risks and Complications

However, DMSO can also interfere with the effectiveness of certain chemotherapy drugs. A 2014 study demonstrated that DMSO could reduce the efficacy of platinum-based chemotherapy drugs like cisplatin, carboplatin, and oxaliplatin.

FDA-Approved Use in Cancer Treatment

The FDA has approved a combination of trametinib and dimethyl sulfoxide (trametinib dimethyl sulfoxide) for treating specific types of cancer, including anaplastic thyroid cancer, melanoma, and non-small cell lung cancer. However, this treatment is only recommended for patients who meet certain criteria.

What does this complex picture mean for cancer patients considering DMSO? The use of DMSO in cancer treatment should always be discussed with an oncologist. Its potential benefits must be carefully weighed against the risks, particularly the possibility of reducing the effectiveness of primary cancer treatments.

Current Research and Future Prospects

While DMSO has been studied for decades, many aspects of its potential medical applications remain unclear. Current research is focused on several areas:

  1. Mechanisms of action: Scientists are working to better understand how DMSO interacts with biological systems at the molecular level.
  2. Potential new applications: Researchers are exploring DMSO’s potential in treating various conditions, from neurological disorders to inflammatory diseases.
  3. Safety and long-term effects: Studies are ongoing to assess the long-term safety of DMSO use, particularly for off-label applications.
  4. Drug delivery: DMSO’s ability to enhance absorption is being investigated for potential use in novel drug delivery systems.

What does the future hold for DMSO in medical applications? While it’s difficult to predict with certainty, the unique properties of DMSO continue to interest researchers. Future studies may provide more concrete evidence for its efficacy in treating conditions like arthritis, potentially leading to new FDA-approved uses.

However, it’s important to remember that the path from promising research to FDA approval is long and rigorous. For now, individuals should rely on FDA-approved treatments and consult with healthcare professionals before considering DMSO for off-label uses.

Legal and Regulatory Considerations

The legal and regulatory landscape surrounding DMSO is complex and varies depending on its intended use and the jurisdiction in question.

FDA Regulation

In the United States, the FDA strictly regulates DMSO as a prescription drug. It’s only approved for treating interstitial cystitis and as part of the trametinib dimethyl sulfoxide combination for specific cancer treatments. Any other medical use of DMSO is considered off-label and not endorsed by the FDA.

Over-the-Counter Availability

Despite FDA regulations, DMSO is sometimes available over-the-counter as a “solvent” or for veterinary use. However, these products are not intended for human medical use and may not meet the same quality and safety standards as pharmaceutical-grade DMSO.

International Regulations

Regulations for DMSO vary internationally. Some countries may have more lenient rules regarding its use and availability, while others may have stricter controls.

What are the implications of these regulations for individuals considering DMSO use? It’s crucial to understand that using DMSO for unapproved medical purposes, even if the product is legally obtained, carries risks and may not be supported by scientific evidence. Always consult with a healthcare professional and adhere to local regulations when considering DMSO use.

Alternatives to DMSO for Arthritis Treatment

Given the risks and lack of FDA approval for DMSO in arthritis treatment, individuals suffering from arthritis should consider FDA-approved and evidence-based alternatives. These may include:

  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Disease-modifying antirheumatic drugs (DMARDs)
  • Corticosteroids
  • Physical therapy and exercise
  • Dietary modifications
  • Alternative therapies like acupuncture or massage (under professional guidance)

How do these alternatives compare to DMSO in terms of efficacy and safety? While individual responses may vary, these treatments have undergone rigorous testing and have demonstrated efficacy in managing arthritis symptoms. They also have well-established safety profiles, allowing healthcare providers to make informed decisions about their use.

It’s important to work closely with a healthcare provider to develop a comprehensive arthritis management plan tailored to your individual needs and circumstances. This approach ensures you receive the most effective and safest treatment possible.

DMSO benefits, uses, risks, and more

While there are many arthritis treatments available, not all medications that companies market to treat the condition have approval for that purpose. One of these is dimethyl sulfoxide (DMSO).

DMSO is a clear, odorless liquid that easily penetrates the skin and other organic membranes.

It is gaining commercial traction as a potential treatment for arthritis symptoms, mostly due to its ability to reduce pain and inflammation. However, it does not have approval as an arthritis treatment.

Despite anecdotal claims of its benefits, using DMSO for arthritis, especially as an over-the-counter treatment, could be dangerous.

Read more to learn about the medical uses for DMSO, how it works, its risks and benefits, and more.

DMSO is a byproduct of the paper-making process. Originally, manufacturers used it primarily as an industrial solvent.

In the 1960s, scientists realized that DMSO could act as a way to administer topical medications. Because biological membranes can rapidly absorb DMSO, the substance can help the skin absorb medicines. It may also have pain and inflammation-reducing properties.

Probably due to its purported anti-inflammatory properties, DMSO has gained some commercial popularity as a treatment for arthritis. Some people claim that DMSO may help reduce pain and inflammation associated with the condition.

However, the Food and Drug Administration (FDA) has not approved DMSO, or any medication that includes DMSO-derived ingredients, to treat arthritis. It only has FDA approval to treat interstitial cystitis, a condition causing bladder pain.

While some research on DMSO for arthritis management may warrant further investigation, the current evidence is anecdotal rather than scientific.

With this in mind, people interested in trying DMSO for arthritis should speak with a doctor first.

In a 2018 review, researchers looked at 109 studies that reported harmful side effects of DMSO in humans. They found that most negative reactions were either short term or rare.

Some of the most common reported adverse reactions were gastrointestinal symptoms, such as halitosis, abdominal aches, stomach cramps, nausea, vomiting, and diarrhea. Other common reactions included dermatological skin reactions, such as rashes, itching, scaling, blistering, and pigmentation increases. There were also rare side effects that included cardiac and neurological reactions.

Additionally, the research indicated that side effects may have links to its administration method. For example, cardiac reactions only occurred when healthcare professionals administered DMSO intravenously, and skin reactions were more likely to develop following topical applications.

Furthermore, researchers found a connection between the dose size and reactions. People who took low doses reported no or mild side effects.

DMSO may also negatively interact with other medications. For example, because DMSO easily absorbs into the skin, using it with other topical medications could dangerously increase the amount of medication the body receives.

People interested in using DMSO for arthritis should contact a doctor before trying it or starting any new medication.

People should only use DMSO when a doctor prescribes it. The most common ways of use are topical, such as a gel or other solution, or intravesically, which involves going through the bladder.

Other methods include oral and intravenous. However, there is not enough research to determine their safety.

DMSO is also in common use as a chemical solvent in scientific and industrial communities. Medically, the only FDA-approved use for DMSO is as a treatment for interstitial cystitis, a chronic and often painful bladder condition.

There is still insufficient scientific evidence proving DMSO is both a safe and effective alternative treatment for these and other conditions.

Cancer and DMSO

While some people may experience relief from certain chemotherapy side effects, such as skin and tissue damage, using DMSO as an alternative treatment for cancer can carry risks. For example, a 2014 study explains how DMSO can interfere with chemotherapy drugs such as cisplatin, carboplatin, and oxaliplatin.

Conversely, a more recent 2020 study shows DMSO may prevent the growth of and encourage the death of cancer cells.

Furthermore, the FDA has approved trametinib dimethyl sulfoxide — a combination of trametinib and dimethyl sulfoxide — for treating anaplastic thyroid cancer, melanoma, and nonsmall cell lung cancer. However, doctors only recommend the treatment if a person and the cancer they have meet certain criteria.

At present, DMSO only has FDA approval to treat interstitial cystitis. While there is some anecdotal evidence that DMSO may alleviate the pain and inflammation associated with arthritis, there is no scientific evidence proving its efficacy.

A person interested in using DMSO for arthritis should contact a doctor.

DMSO benefits, uses, risks, and more

While there are many arthritis treatments available, not all medications that companies market to treat the condition have approval for that purpose. One of these is dimethyl sulfoxide (DMSO).

DMSO is a clear, odorless liquid that easily penetrates the skin and other organic membranes.

It is gaining commercial traction as a potential treatment for arthritis symptoms, mostly due to its ability to reduce pain and inflammation. However, it does not have approval as an arthritis treatment.

Despite anecdotal claims of its benefits, using DMSO for arthritis, especially as an over-the-counter treatment, could be dangerous.

Read more to learn about the medical uses for DMSO, how it works, its risks and benefits, and more.

DMSO is a byproduct of the paper-making process. Originally, manufacturers used it primarily as an industrial solvent.

In the 1960s, scientists realized that DMSO could act as a way to administer topical medications. Because biological membranes can rapidly absorb DMSO, the substance can help the skin absorb medicines. It may also have pain and inflammation-reducing properties.

Probably due to its purported anti-inflammatory properties, DMSO has gained some commercial popularity as a treatment for arthritis. Some people claim that DMSO may help reduce pain and inflammation associated with the condition.

However, the Food and Drug Administration (FDA) has not approved DMSO, or any medication that includes DMSO-derived ingredients, to treat arthritis. It only has FDA approval to treat interstitial cystitis, a condition causing bladder pain.

While some research on DMSO for arthritis management may warrant further investigation, the current evidence is anecdotal rather than scientific.

With this in mind, people interested in trying DMSO for arthritis should speak with a doctor first.

In a 2018 review, researchers looked at 109 studies that reported harmful side effects of DMSO in humans. They found that most negative reactions were either short term or rare.

Some of the most common reported adverse reactions were gastrointestinal symptoms, such as halitosis, abdominal aches, stomach cramps, nausea, vomiting, and diarrhea. Other common reactions included dermatological skin reactions, such as rashes, itching, scaling, blistering, and pigmentation increases. There were also rare side effects that included cardiac and neurological reactions.

Additionally, the research indicated that side effects may have links to its administration method. For example, cardiac reactions only occurred when healthcare professionals administered DMSO intravenously, and skin reactions were more likely to develop following topical applications.

Furthermore, researchers found a connection between the dose size and reactions. People who took low doses reported no or mild side effects.

DMSO may also negatively interact with other medications. For example, because DMSO easily absorbs into the skin, using it with other topical medications could dangerously increase the amount of medication the body receives.

People interested in using DMSO for arthritis should contact a doctor before trying it or starting any new medication.

People should only use DMSO when a doctor prescribes it. The most common ways of use are topical, such as a gel or other solution, or intravesically, which involves going through the bladder.

Other methods include oral and intravenous. However, there is not enough research to determine their safety.

DMSO is also in common use as a chemical solvent in scientific and industrial communities. Medically, the only FDA-approved use for DMSO is as a treatment for interstitial cystitis, a chronic and often painful bladder condition.

There is still insufficient scientific evidence proving DMSO is both a safe and effective alternative treatment for these and other conditions.

Cancer and DMSO

While some people may experience relief from certain chemotherapy side effects, such as skin and tissue damage, using DMSO as an alternative treatment for cancer can carry risks. For example, a 2014 study explains how DMSO can interfere with chemotherapy drugs such as cisplatin, carboplatin, and oxaliplatin.

Conversely, a more recent 2020 study shows DMSO may prevent the growth of and encourage the death of cancer cells.

Furthermore, the FDA has approved trametinib dimethyl sulfoxide — a combination of trametinib and dimethyl sulfoxide — for treating anaplastic thyroid cancer, melanoma, and nonsmall cell lung cancer. However, doctors only recommend the treatment if a person and the cancer they have meet certain criteria.

At present, DMSO only has FDA approval to treat interstitial cystitis. While there is some anecdotal evidence that DMSO may alleviate the pain and inflammation associated with arthritis, there is no scientific evidence proving its efficacy.

A person interested in using DMSO for arthritis should contact a doctor.

Scientists have found a way to destroy the toxic “eternal chemicals” that flooded the world – Gazeta.Ru

Scientists have found a way to destroy the toxic “eternal chemicals” that flooded the world – Gazeta.Ru | News

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Researchers have shown that a mixture of soap and DMSO solvent can break down per- and polyfluoroalkyl compounds (PFAS), known as “timeless chemicals”. Development reported Science .

Two years ago, researchers from the US Environmental Protection Agency placed a sample of PFAS in a common solvent (DMSO) to study toxicity, but the substance began to degrade. The new study builds on this observation. Scientists from Northwestern University studied various mixtures containing DMSO. The mixture of DMSO and sodium hydroxide, a common soap ingredient, showed the greatest effectiveness when heated to boiling point.

This method works with approximately 40% PFAS. Now it has to be tested on large volumes. Those compounds, the destruction of which chemists have studied, are used in fire-fighting foams and the production of non-stick coatings.

PFAS are known as “timeless chemicals” because they can remain in the environment for decades. Recently, they have even been found in rainwater in the Tibetan Plateau in quantities far exceeding safe ones. The new method will cheaply and safely cleanse the planet of potentially toxic and carcinogenic substances.

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DMSO (dimethyl sulfoxide) in the best quality pharmaceutical premium

DMSO – Universal Solvent (100 ml)

Dimethyl Sulfoxide (DMSO) is a colorless and odorless organic universal solvent used in laboratory and technical applications. Very high purity of 99.9% meets Ph.Eur certification. Depending on the application, it is easily mixed with water in any ratio. It has an amazing amount of good properties and is extremely versatile.

Benefits of using DMSO:

  • Pharmaceutical purity according to the European Pharmacopoeia

  • Integrated dropper for easy dosing

  • TÜV Rheinland tested: 100% EU-compliant

  • Filled in break-proof and child-proof HDPE bottle

  • is perfect for travel, outdoor or crisis preparedness!

  • The original, only from AQUARIUS pro life

Disadvantages compared to other DMSO solutions:

  • often no pharmaceutical safety

  • No TÜV-tested EU conformity

  • Often bottled in fragile glass bottles

  • is therefore impractical for travel and outdoor use.

Benefits of using DMSO:

  • Pharmaceutical purity according to the European Pharmacopoeia

  • Integrated dropper for easy dosing

  • TÜV Rheinland tested: 100% EU-compliant

  • Filled in break-proof and child-proof HDPE bottle

  • is perfect for travel, outdoor or crisis preparedness!

  • The original, only from AQUARIUS pro life

Disadvantages compared to other DMSO solutions:

  • often no pharmaceutical safety

  • No TÜV-tested EU conformity

  • Often bottled in fragile glass bottles

  • is therefore impractical for travel and outdoor use.

Content:

100ml 99.9% DMSO ultrapure Ph.Eur in HDPE bottle

(CAS no: 67-68-5, EC no: 200-664-3) Taric: 29091990

Storage and shelf life:

Store in a dry place at room temperature, well closed and out of the reach of children!

DMSO becomes crystalline and solid at low temperatures below 18°C, eg during transport or in winter. This is completely normal and harmless. When heated in a warm water bath, it becomes liquid again. Remove residues on fabrics and surfaces immediately with a damp cloth. DMSO is a long-term stable compound and therefore has a very long shelf life.

Areas of use:

Depending on the application, DMSO can be easily mixed with water in any ratio. Dimethyl sulfoxide has an amazing amount of good properties and is extremely versatile, being used in cosmetics, pharmaceuticals, and as a widely used solvent in laboratories and engineering, among others.

Environment protection:

The raw materials for our sustainable packaging and product information sheet come from sustainable forestry (FSC) and are printed in a climate-neutral way. Please recycle them. Our bottles, child-resistant cap and label are made from polyethylene and are recyclable.

Important note:

Use solvents safely! Always read the label and product information before use.

Keep out of reach of children.

“Glass or HDPE bottle – which is better?”.

Many suppliers use amber glass bottles and advertise that they are much safer and better protect the contents from, for example, UV rays or soluble plastic. However, the fact is that this ingredient is not sensitive to either light or UV, and HDPE (High Density Polyethylene) is a legally approved and suitable storage material. Every industrial manufacturer of DMSO produces, bottles and stores it in HDPE cans, drums or containers.

How can quality be improved by pouring into glass bottles?

Conclusion: HDPE is a legal plastic for storing DMSO and does not mix with the filler in any way. Precise drip filling is much easier with our unbreakable HDPE bottle.

That’s why we only use approved HDPE and not glass – for your safety!

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