About all

Does dmso work. DMSO: Uses, Effectiveness, and Potential Risks Explored

by alexxlab

What is DMSO and how does it work. Is DMSO effective for treating various conditions. What are the potential side effects and risks of using DMSO. How is DMSO used and dosed properly. What precautions should be taken when using DMSO.

Содержание

Understanding DMSO: Origin and Basic Properties

Dimethyl sulfoxide (DMSO) is a versatile chemical compound with a fascinating history and diverse applications. Originally a byproduct of paper manufacturing, DMSO is derived from lignin, a substance found in wood. Its journey from industrial solvent to potential therapeutic agent spans over a century.

DMSO’s unique properties include:

  • High solubility in both water and organic compounds
  • Ability to penetrate biological membranes easily
  • Potential to enhance the absorption of other substances
  • Anti-inflammatory and analgesic properties

These characteristics have sparked interest in DMSO’s potential medical applications, leading to extensive research and debate within the scientific community.

FDA-Approved Uses of DMSO in Medicine

While DMSO has been touted for various uses, it’s crucial to distinguish between approved medical applications and unproven claims. The U.S. Food and Drug Administration (FDA) has approved DMSO for a specific medical use:

Treatment of Interstitial Cystitis

DMSO is FDA-approved as a prescription medication for treating symptoms of painful bladder syndrome, also known as interstitial cystitis. In this application, DMSO is used to wash the bladder, providing relief from pain and other associated symptoms.

Is DMSO effective for interstitial cystitis. Clinical studies have shown that DMSO can significantly improve symptoms in many patients with this condition, making it a valuable treatment option for those who have not responded to other therapies.

Potential Medical Applications of DMSO

Beyond its FDA-approved use, DMSO has been studied and used off-label for various conditions. It’s important to note that while some of these applications show promise, more research is often needed to establish efficacy and safety.

Complex Regional Pain Syndrome

DMSO has shown potential in treating complex regional pain syndrome, a chronic condition characterized by severe pain, usually in an arm or leg. Topical application of DMSO cream may help alleviate pain in some patients with this condition.

Extravasation Treatment

In medical settings, DMSO has been used to treat extravasation – the leakage of intravenous drugs from the vein into surrounding tissue. This application is particularly relevant for certain chemotherapy drugs that can cause tissue damage if they leak outside the vein.

Other Potential Applications

Researchers have explored DMSO’s potential in treating various other conditions, including:

  • Osteoarthritis
  • Rheumatoid arthritis
  • Scleroderma
  • Wound healing
  • Burns
  • Headaches

However, it’s crucial to emphasize that evidence supporting these uses is often limited or inconclusive. More rigorous studies are needed to determine DMSO’s effectiveness in these areas.

The Controversy Surrounding DMSO as an Alternative Treatment

DMSO has gained attention in alternative medicine circles, with proponents claiming its effectiveness for a wide range of conditions. However, these claims often lack solid scientific backing.

DMSO and Cancer Treatment

One of the most controversial claims about DMSO is its purported ability to treat cancer. Can DMSO be used as an alternative cancer treatment. The American Cancer Society firmly states that there is no scientific evidence supporting the use of DMSO in cancer treatment. In fact, relying on DMSO instead of proven cancer therapies could lead to dangerous delays in receiving proper treatment.

Osteoarthritis Pain Relief

While DMSO has been promoted for osteoarthritis pain relief, recent analyses of studies have found that it may not be significantly more effective than placebo in reducing joint pain. This highlights the importance of critically evaluating claims and relying on evidence-based treatments.

Understanding DMSO’s Mechanism of Action

DMSO’s potential therapeutic effects are attributed to several mechanisms:

  1. Anti-inflammatory properties: DMSO may help reduce inflammation in various tissues.
  2. Analgesic effects: It may help alleviate pain through direct action on nerve fibers.
  3. Enhanced drug delivery: DMSO can increase the absorption of other substances through the skin.
  4. Antioxidant activity: Some studies suggest DMSO may have antioxidant properties, potentially protecting cells from damage.

How does DMSO work at the cellular level. DMSO’s ability to easily penetrate biological membranes allows it to interact with various cellular components, potentially influencing cellular processes and signaling pathways. However, the exact mechanisms behind its effects in different conditions are not fully understood and require further research.

Potential Risks and Side Effects of DMSO Use

While DMSO has shown potential benefits, it’s not without risks. Understanding these potential side effects is crucial for anyone considering its use.

Common Side Effects

When applied topically, DMSO can cause:

  • Skin irritation
  • Itching and burning sensation
  • A strong garlic-like odor
  • Stomach upset

More Serious Concerns

In some cases, DMSO use may lead to more severe side effects:

  • Severe allergic reactions
  • Headaches
  • Dizziness and drowsiness (when taken orally)
  • Nausea and vomiting
  • Diarrhea or constipation
  • Decreased appetite

In high concentrations, DMSO can potentially cause life-threatening reactions. This underscores the importance of using DMSO only under medical supervision and at appropriate concentrations.

Drug Interactions

DMSO can interact with various medications, potentially increasing their effects. This can lead to serious health issues. Medications that may interact with DMSO include:

  • Blood thinners
  • Steroids
  • Sedatives

Always consult with a healthcare provider before using DMSO, especially if you’re taking other medications.

Proper Usage and Dosing of DMSO

The appropriate use of DMSO is crucial for maximizing potential benefits while minimizing risks. However, it’s important to note that outside of its FDA-approved use for interstitial cystitis, there are no standardized guidelines for DMSO dosing.

Topical Application

DMSO is primarily used topically, applied directly to the skin. For osteoarthritis, a common off-label use, a typical regimen might involve:

  • Concentration: 25% DMSO gel
  • Frequency: Applied 3-4 times daily

However, concentrations in over-the-counter products can vary widely, ranging from 10% to 90%. Higher concentrations increase the risk of side effects and should be used with caution.

Importance of Product Quality

When using DMSO, product quality is paramount. Some DMSO products sold without a prescription may be industrial grade, containing impurities that can be absorbed through the skin and potentially cause harm. Always choose pharmaceutical-grade DMSO from reputable sources.

Precautions for Safe Use

To use DMSO safely:

  1. Clean the application area thoroughly before use to prevent unwanted substances from being absorbed.
  2. Start with a lower concentration and increase gradually if needed.
  3. Monitor for any adverse reactions and discontinue use if side effects occur.
  4. Never use DMSO without consulting a healthcare provider, especially if you have underlying health conditions.

Is there a safe way to use DMSO at home. While some people use DMSO for various purposes at home, it’s crucial to approach this with caution. Always consult with a healthcare provider before using DMSO, follow their guidance carefully, and use only pharmaceutical-grade products.

Special Considerations and Contraindications

Certain groups should exercise extra caution or avoid DMSO altogether:

Pregnancy and Breastfeeding

Pregnant women and those who are breastfeeding should not use DMSO. The effects of DMSO on fetal development and infants are not well understood, and potential risks outweigh any benefits.

Pre-existing Health Conditions

Individuals with certain health conditions should consult their healthcare provider before using DMSO. These conditions include:

  • Diabetes
  • Asthma
  • Liver conditions
  • Kidney conditions

DMSO may interact with these conditions or affect their management, necessitating careful consideration and medical supervision.

Skin Sensitivity

People with sensitive skin or a history of skin reactions should be particularly cautious when using topical DMSO. A patch test on a small area of skin is advisable before more extensive application.

The Regulatory Landscape and DMSO

Understanding the regulatory status of DMSO is crucial for consumers and healthcare providers alike.

FDA Regulation

The FDA has approved DMSO as a prescription drug for interstitial cystitis. However, its regulation as a supplement or for other uses is less stringent. How is DMSO regulated by the FDA. Unlike prescription drugs, dietary supplements containing DMSO are not required to undergo rigorous testing for safety and efficacy before being marketed.

Quality Control Challenges

The lack of stringent regulation for non-prescription DMSO products raises concerns about quality control. Consumers should be aware that the purity, concentration, and safety of over-the-counter DMSO products can vary significantly.

International Perspectives

Regulatory approaches to DMSO vary internationally. Some countries have more permissive policies regarding its use, while others maintain stricter controls. This global variation underscores the need for consumers to be well-informed and cautious, especially when obtaining DMSO from international sources.

In conclusion, while DMSO shows promise in certain medical applications, its use remains controversial and potentially risky outside of approved indications. As research continues, a clearer picture of DMSO’s benefits and risks may emerge. For now, individuals considering DMSO should approach it with caution, always under the guidance of a qualified healthcare provider, and with a critical eye toward claims of its effectiveness.

DMSO: Uses and Risks

Written by Joseph Saling

  • Why Do People Use DMSO?
  • What Are the Risks of Using DMSO?

DMSO, or dimethyl sulfoxide, is a by-product of paper making. It comes from a substance found in wood.

DMSO has been used as an industrial solvent since the mid-1800s. From about the mid-20th century, researchers have explored its use as an anti-inflammatory agent.

The FDA has approved DMSO as a prescription medication for treating symptoms of painful bladder syndrome. It’s also used under medical supervision to treat several other conditions, including shingles.

DMSO is easily absorbed by the skin. It’s sometimes used to increase the body’s absorption of other medications.

DMSO is available without a prescription most often in gel or cream form. It can be purchased in health food stores, by mail order, and on the Internet.

While it can sometimes be found as an oral supplement, its safety is unclear. DMSO is primarily used by applying it to the skin.

DMSO has been used to try to relieve the pain of osteoarthritis. It has also been promoted as an “alternative” cancer treatment.

People have used it to try to treat wounds, burns, and other injuries. People have also used it to try to treat such conditions as:

  • Headache
  • Rheumatoid arthritis
  • Eye problems
  • Scars
  • Scleroderma (disease that causes scar tissue to form in the skin)

Other than its use as a prescription medicine, there is little or no scientific evidence to support other claims made about DMSO’s effectiveness.

The American Cancer Society says there is no evidence to support the use of DMSO to treat cancer. Using it that way could cause serious delays in getting proper and effective treatment.

A recent analysis of studies on the use of DMSO to relieve osteoarthritis pain found that it was not significantly more effective than placebo in relieving joint pain.

There are no studies that provide guidelines for determining the proper dose of DMSO. The gel used to treat osteoarthritis typically has a concentration of 25%. It is applied three or four times a day. But DMSO sold without a prescription can range from 10% concentration to 90%.

Some DMSO on the market may actually be industrial grade. Industrial grade DMSO may contain a number of impurities that can easily be absorbed into the skin with potentially serious health effects.

The most frequent side effects from using DMSO on the skin include:

  • Stomach upset
  • Skin irritation
  • Strong odor of garlic

More serious side effects include:

  • Severe allergic reactions
  • Headaches
  • Itching and burning when applied to the skin

DMSO can also cause a deadly reaction when used in high concentrations.

Using DMSO by mouth can cause:

  • Dizziness
  • Drowsiness
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Decreased appetite

DMSO can increase the effect of some medicines, which can lead to serious health issues. Examples of such medicines include:

  • Blood thinners
  • Steroids
  • Sedatives

The biggest concern of DMSO as a solvent is that when it gets on the skin it will cause anything on the skin to be absorbed. So be sure to wash your hands and skin well before using.

Pregnant women and women who are breastfeeding should not use DMSO, since little is known about its possible effects on the fetus or infant.

You should also not use DMSO without talking to your doctor if you have:

  • Diabetes
  • Asthma
  • Liver and kidney conditions

Always keep in mind that supplements are not regulated by the FDA the same was as drugs are. The manufacturer does not have to prove that a supplement is safe or effective before selling.

Top Picks

Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Dimethylsulfoxide (DMSO) is a chemical that dissolves many organic and inorganic substances. It’s available as a prescription drug and dietary supplement.

DMSO helps medicines get through the skin and can affect proteins, carbohydrates, fats, and water in the body.

People use DMSO for bladderinflammation (interstitial cystitis), limb pain that usually occurs after an injury, and leakage of an IV drug from the vein into surrounding skin and tissue. It is also used for osteoarthritis, bed sores, stomach ulcers, and many other conditions, but there is no good scientific evidence to support most of these other uses.

Don’t confuse DMSO with Methylsulfonylmethane (MSM). These are not the same.

Uses & Effectiveness ?

Effective for

  • Painful bladder syndrome (interstitial cystitis). DMSO is an FDA-approved product for the treatment of this condition. Washing the bladder with DMSO improves some symptoms, such as pain.

Possibly Effective for

  • Limb pain that usually occurs after an injury (complex regional pain syndrome). Applying DMSO cream to the skin seems to improve pain in people with this condition.
  • Leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation). Some chemotherapy drugs can cause skin and tissue damage if they leak from the vein. Applying DMSO to the skin might prevent further damage if this happens.

Possibly Ineffective for

  • Hardening of skin and connective tissue (scleroderma). Applying DMSO to the skin doesn’t help treat symptoms of scleroderma.

There is interest in using DMSO for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Special Precautions and Warnings

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Pregnancy and breast-feeding: There isn’t enough reliable information to know if DMSO is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Certain blood disorders. Injecting DMSO by IV might cause red blood cells to break down. This might be a problem for people with certain blood disorders. DMSO might make these conditions worse.

Kidney problems: DMSO might harm the kidneys. Check with a healthcare provider before using DMSO if you have kidney problems.

Liver problems: DMSO might harm the liver. Check with a healthcare provider before using DMSO if you have liver problems.br/>

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • DMSO can sometimes increase how much medicine the body absorbs. Applying DMSO to the skin, eyes, or ears at the same time as applying medication can increase how much medicine the body absorbs. This might increase the effects and side effects of the medicine.

  • DMSO might slow blood clotting. Taking DMSO along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

  • Using DMSO with sulindac might reduce how well sulindac works to treat pain. There is also a concern that using DMSO with sulindac can increase the risk for nerve pain.

  • DMSO can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking DMSO with these medications might increase the chance of side effects.

  • Using DMSO with verteporfin might reduce how well verteporfin works.

  • Using DMSO to dissolve platinum agents onto the skin might reduce how well these drugs work to treat cancer. Examples of platinum agents include carboplatin, cisplatin, and oxaliplatin.

Dosing

DMSO has most often been applied to the skin by adults in various forms, including creams, gels, and solutions. It is also applied inside the bladder. DMSO is available as a prescription and in dietary supplements. Speak with a healthcare provider before use.

View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

Scientists have found a way to destroy the toxic “eternal chemicals” that flooded the world – Gazeta.Ru

Scientists have found a way to destroy the toxic “eternal chemicals” that flooded the world – Gazeta.Ru | News

close

100%

Researchers have shown that a mixture of soap and DMSO solvent can break down per- and polyfluoroalkyl compounds (PFAS), known as “timeless chemicals”. Development reported Science .

Two years ago, researchers from the US Environmental Protection Agency placed a sample of PFAS in a common solvent (DMSO) to study toxicity, but the substance began to degrade. The new study builds on this observation. Scientists from Northwestern University studied various mixtures containing DMSO. The mixture of DMSO and sodium hydroxide, a common soap ingredient, showed the greatest effectiveness when heated to boiling point.

This method works with approximately 40% PFAS. Now it has to be tested on large volumes. Those compounds, the destruction of which chemists have studied, are used in fire-fighting foams and the production of non-stick coatings.

PFAS are known as “timeless chemicals” because they can remain in the environment for decades. Recently, they have even been found in rainwater in the Tibetan Plateau in quantities far exceeding safe ones. The new method will cheaply and safely cleanse the planet of potentially toxic and carcinogenic substances.

Subscribe to Gazeta.Ru in News, Zen and Telegram.
To report a bug, highlight the text and press Ctrl+Enter

News

Zen

Telegram

Artur Muradyan

Is it worth vacationing in Turkey and Egypt in the summer of 2023?

About holidays in popular foreign destinations

Alexander Tikhomirov

How to teach a child financial literacy

Alexander Tikhomirov, Executive Director of SberLife Insurance, on correct pocket spending

Georgy Bovt

Why does Russia need a “grain deal”

Who is pouring water on whose mill in the food exports of the Black Sea region

Alena Solntseva

The Librarian TV Series: Lord of the Battle Reading Rooms

About the new show with Nikita Efremov

Aram Ter-Ghazaryan

How Internet Cherkizon was destroyed in the “quarrel in the sandbox”

What threatens marketplaces with the new law on online trading

DMSO (dimethyl sulfoxide) in the best quality pharmaceutical premium

DMSO – Universal Solvent (100 ml)

Dimethyl Sulfoxide (DMSO) is a colorless and odorless organic universal solvent used in laboratory and technical applications. Very high purity of 99.9% meets Ph.Eur certification. Depending on the application, it is easily mixed with water in any ratio. It has an amazing amount of good properties and is extremely versatile.

Benefits of using DMSO:

  • Pharmaceutical purity according to the European Pharmacopoeia

  • Integrated dropper for easy dosing

  • TÜV Rheinland tested: 100% EU-compliant

  • Filled in break-proof and child-proof HDPE bottle

  • is perfect for travel, outdoor or crisis preparedness!

  • The original, only from AQUARIUS pro life

Disadvantages compared to other DMSO solutions:

  • often no pharmaceutical safety

  • No TÜV-tested EU conformity

  • Often bottled in fragile glass bottles

  • is therefore impractical for travel and outdoor use.

Benefits of using DMSO:

  • Pharmaceutical purity according to the European Pharmacopoeia

  • Integrated dropper for easy dosing

  • TÜV Rheinland tested: 100% EU-compliant

  • Filled in break-proof and child-proof HDPE bottle

  • is perfect for travel, outdoor or crisis preparedness!

  • The original, only from AQUARIUS pro life

Disadvantages compared to other DMSO solutions:

  • often no pharmaceutical safety

  • No TÜV-tested EU conformity

  • Often bottled in fragile glass bottles

  • is therefore impractical for travel and outdoor use.

Content:

100ml 99.9% DMSO ultrapure Ph.Eur in HDPE bottle

(CAS no: 67-68-5, EC no: 200-664-3) Taric: 29091990

Storage and shelf life:

Store in a dry place at room temperature, well closed and out of the reach of children!

DMSO becomes crystalline and solid at low temperatures below 18°C, eg during transport or in winter. This is completely normal and harmless. When heated in a warm water bath, it becomes liquid again. Remove residues on fabrics and surfaces immediately with a damp cloth. DMSO is a long-term stable compound and therefore has a very long shelf life.

Areas of use:

Depending on the application, DMSO can be easily mixed with water in any ratio. Dimethyl sulfoxide has an amazing amount of good properties and is extremely versatile, being used in cosmetics, pharmaceuticals, and as a widely used solvent in laboratories and engineering, among others.

Environment protection:

The raw materials for our sustainable packaging and product information sheet come from sustainable forestry (FSC) and are printed in a climate-neutral way. Please recycle them. Our bottles, child-resistant cap and label are made from polyethylene and are recyclable.

Important note:

Use solvents safely! Always read the label and product information before use.

Keep out of reach of children.

“Glass or HDPE bottle – which is better?”.

Many suppliers use amber glass bottles and advertise that they are much safer and better protect the contents from, for example, UV rays or soluble plastic. However, the fact is that this ingredient is not sensitive to either light or UV, and HDPE (High Density Polyethylene) is a legally approved and suitable storage material. Every industrial manufacturer of DMSO produces, bottles and stores it in HDPE cans, drums or containers.

How can quality be improved by pouring into glass bottles?

Conclusion: HDPE is a legal plastic for storing DMSO and does not mix with the filler in any way. Precise drip filling is much easier with our unbreakable HDPE bottle.

That’s why we only use approved HDPE and not glass – for your safety!

Other customers also bought: