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Does dmso work. DMSO: Uses, Effectiveness, and Potential Risks Explored

by alexxlab

What is DMSO and how does it work. Is DMSO effective for treating various conditions. What are the potential side effects and risks of using DMSO. How is DMSO used and dosed. What precautions should be taken when using DMSO.

Understanding DMSO: Origins and Basic Properties

Dimethyl sulfoxide (DMSO) is a chemical compound with a fascinating history and diverse applications. Originally discovered as a by-product of paper production, DMSO is derived from lignin, a substance found in wood. Its journey from industrial solvent to potential therapeutic agent spans over a century.

DMSO’s unique properties include:

  • High solvent power, capable of dissolving many organic and inorganic substances
  • Ability to penetrate biological membranes, including skin
  • Potential to enhance the absorption of other substances
  • Anti-inflammatory properties

These characteristics have made DMSO an intriguing subject for both industrial and medical research. But what exactly makes DMSO so special?

The Science Behind DMSO’s Absorption

DMSO’s molecular structure allows it to easily pass through cell membranes. This property is key to its ability to penetrate the skin and potentially carry other substances with it. How does this work on a molecular level? DMSO molecules can temporarily alter the structure of skin lipids, creating pathways for itself and other compounds to enter the body.

FDA-Approved Uses of DMSO in Medicine

While DMSO has been the subject of numerous studies and claims, it’s important to distinguish between its approved medical uses and other purported applications. The U.S. Food and Drug Administration (FDA) has approved DMSO for a specific medical condition. What is this approved use?

DMSO is FDA-approved as a prescription medication for treating symptoms of painful bladder syndrome, also known as interstitial cystitis. In this application, DMSO is used to wash the bladder, providing relief from pain and other symptoms associated with this chronic condition.

DMSO in Treating Complex Regional Pain Syndrome

Beyond its FDA-approved use, DMSO has shown promise in treating complex regional pain syndrome (CRPS), a form of chronic pain that typically affects limbs after an injury. Research suggests that applying DMSO cream to the skin may help alleviate pain in individuals suffering from this condition. How does DMSO potentially provide relief in CRPS cases?

The mechanism is not fully understood, but it’s believed that DMSO’s anti-inflammatory properties and its ability to penetrate deep into tissues may play a role in pain reduction. Additionally, DMSO might help improve blood flow to affected areas, potentially aiding in healing and pain relief.

Exploring DMSO’s Potential in Various Medical Conditions

While scientific evidence is limited for many claims, DMSO has been explored as a potential treatment for a wide range of conditions. These include:

  • Osteoarthritis
  • Rheumatoid arthritis
  • Headaches
  • Wound healing
  • Burns
  • Scleroderma
  • Eye problems
  • Scar reduction

It’s crucial to note that for most of these applications, robust scientific evidence is lacking. Why is there such a discrepancy between anecdotal reports and scientific evidence?

The gap often stems from a lack of large-scale, well-designed clinical trials. Many claims about DMSO’s effectiveness are based on small studies, animal research, or anecdotal evidence, which are not sufficient to establish medical efficacy and safety.

DMSO and Cancer: Separating Fact from Fiction

One of the more controversial claims about DMSO is its purported use as an alternative cancer treatment. However, reputable organizations like the American Cancer Society have stated that there is no scientific evidence supporting DMSO’s effectiveness in treating cancer. Why is it dangerous to promote DMSO as a cancer treatment?

Promoting unproven treatments can lead to delays in seeking proper, evidence-based cancer care. This delay can have serious, potentially life-threatening consequences for cancer patients. It’s crucial for individuals diagnosed with cancer to work closely with oncologists and follow established treatment protocols.

DMSO Administration: Forms and Methods

DMSO is available in various forms, each with its own set of considerations. The most common forms include:

  1. Gels and creams for topical application
  2. Solutions for bladder instillation (prescription only)
  3. Oral supplements (safety and efficacy unclear)

How is DMSO typically administered for its approved use in interstitial cystitis?

For interstitial cystitis, DMSO is administered as a bladder instillation. This involves inserting a catheter to deliver the DMSO solution directly into the bladder, where it’s held for a specific period before being drained. This procedure is performed under medical supervision.

Topical Application of DMSO

The most common over-the-counter use of DMSO is topical application. When applying DMSO to the skin, what precautions should be taken?

  • Ensure the skin is clean and free from other substances
  • Use only pharmaceutical-grade DMSO products
  • Start with a lower concentration to test for skin sensitivity
  • Avoid applying to broken or irritated skin
  • Be aware that DMSO can carry other substances on the skin into the body

Potential Side Effects and Risks of DMSO Use

While DMSO is generally considered safe when used as directed, it can cause various side effects. What are the most common side effects associated with topical DMSO use?

  • Skin irritation, including itching and burning
  • Strong garlic-like body odor
  • Stomach upset
  • Headaches

More serious side effects, though less common, can include:

  • Severe allergic reactions
  • Liver and kidney issues
  • Vision changes

DMSO and Drug Interactions

One of the most significant concerns with DMSO use is its potential to interact with other medications. How does DMSO affect other drugs?

DMSO can enhance the absorption and effect of other medications, potentially leading to increased potency or side effects. This is particularly concerning with:

  • Blood thinners
  • Steroids
  • Sedatives
  • Heart medications

Due to these potential interactions, it’s crucial to consult with a healthcare provider before using DMSO, especially if you’re taking other medications.

Dosing and Concentration: Navigating the DMSO Landscape

One of the challenges in using DMSO is the lack of standardized dosing guidelines for many of its purported uses. What concentrations of DMSO are typically used?

For osteoarthritis, some studies have used gels with a 25% DMSO concentration, applied three to four times daily. However, over-the-counter products can range from 10% to 90% concentration. This wide range highlights the importance of caution and professional guidance when using DMSO.

The Importance of Pharmaceutical-Grade DMSO

A critical consideration when using DMSO is the quality and purity of the product. Why is it essential to use pharmaceutical-grade DMSO?

Industrial-grade DMSO may contain impurities that can be harmful when absorbed through the skin. These impurities could potentially cause serious health issues. Always ensure you’re using pharmaceutical-grade DMSO from a reputable source when considering its use for health purposes.

Special Precautions and Contraindications for DMSO Use

Certain groups should exercise extra caution or avoid DMSO altogether. Who should be particularly cautious about using DMSO?

  • Pregnant women and breastfeeding mothers
  • Individuals with liver or kidney conditions
  • People with diabetes
  • Those with asthma
  • Individuals taking multiple medications

Why are these groups at higher risk? The effects of DMSO on fetal development and infant health are not well-studied, making it a potential risk for pregnant and breastfeeding women. For those with liver or kidney conditions, DMSO’s metabolism and excretion could pose additional stress on these organs. Diabetics and asthmatics may experience unpredictable reactions, and those on multiple medications face an increased risk of drug interactions.

DMSO and Skin Preparation

Proper skin preparation is crucial when using topical DMSO. What steps should be taken before applying DMSO to the skin?

  1. Thoroughly clean the area with mild soap and water
  2. Rinse completely to remove any soap residue
  3. Pat the skin dry with a clean towel
  4. Ensure hands are also clean before application

These steps are vital because DMSO can carry substances from the skin’s surface into the body. Any contaminants, including soap residue or environmental pollutants, could potentially be absorbed along with the DMSO.

The Regulatory Landscape: DMSO as a Supplement

Understanding the regulatory status of DMSO is crucial for consumers. How is DMSO regulated when sold as a supplement?

In the United States, DMSO sold as a dietary supplement falls under different regulations than prescription drugs. The FDA does not require supplement manufacturers to prove the safety and efficacy of their products before marketing them. This regulatory difference means that consumers must be particularly cautious and well-informed when considering DMSO supplements.

Evaluating DMSO Product Claims

Given the limited regulation of DMSO as a supplement, how can consumers evaluate product claims?

  • Look for products from reputable manufacturers
  • Check for third-party testing certifications
  • Be wary of exaggerated or unsupported health claims
  • Consult healthcare professionals for guidance
  • Research scientific studies on DMSO for specific conditions

It’s important to approach DMSO products with a critical eye, especially when they make bold claims about treating various health conditions. Remember that anecdotal evidence and testimonials are not substitutes for scientific research and clinical trials.

DMSO: Uses and Risks

Written by Joseph Saling

  • Why Do People Use DMSO?
  • What Are the Risks of Using DMSO?

DMSO, or dimethyl sulfoxide, is a by-product of paper making. It comes from a substance found in wood.

DMSO has been used as an industrial solvent since the mid-1800s. From about the mid-20th century, researchers have explored its use as an anti-inflammatory agent.

The FDA has approved DMSO as a prescription medication for treating symptoms of painful bladder syndrome. It’s also used under medical supervision to treat several other conditions, including shingles.

DMSO is easily absorbed by the skin. It’s sometimes used to increase the body’s absorption of other medications.

DMSO is available without a prescription most often in gel or cream form. It can be purchased in health food stores, by mail order, and on the Internet.

While it can sometimes be found as an oral supplement, its safety is unclear. DMSO is primarily used by applying it to the skin.

DMSO has been used to try to relieve the pain of osteoarthritis. It has also been promoted as an “alternative” cancer treatment.

People have used it to try to treat wounds, burns, and other injuries. People have also used it to try to treat such conditions as:

  • Headache
  • Rheumatoid arthritis
  • Eye problems
  • Scars
  • Scleroderma (disease that causes scar tissue to form in the skin)

Other than its use as a prescription medicine, there is little or no scientific evidence to support other claims made about DMSO’s effectiveness.

The American Cancer Society says there is no evidence to support the use of DMSO to treat cancer. Using it that way could cause serious delays in getting proper and effective treatment.

A recent analysis of studies on the use of DMSO to relieve osteoarthritis pain found that it was not significantly more effective than placebo in relieving joint pain.

There are no studies that provide guidelines for determining the proper dose of DMSO. The gel used to treat osteoarthritis typically has a concentration of 25%. It is applied three or four times a day. But DMSO sold without a prescription can range from 10% concentration to 90%.

Some DMSO on the market may actually be industrial grade. Industrial grade DMSO may contain a number of impurities that can easily be absorbed into the skin with potentially serious health effects.

The most frequent side effects from using DMSO on the skin include:

  • Stomach upset
  • Skin irritation
  • Strong odor of garlic

More serious side effects include:

  • Severe allergic reactions
  • Headaches
  • Itching and burning when applied to the skin

DMSO can also cause a deadly reaction when used in high concentrations.

Using DMSO by mouth can cause:

  • Dizziness
  • Drowsiness
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Decreased appetite

DMSO can increase the effect of some medicines, which can lead to serious health issues. Examples of such medicines include:

  • Blood thinners
  • Steroids
  • Sedatives

The biggest concern of DMSO as a solvent is that when it gets on the skin it will cause anything on the skin to be absorbed. So be sure to wash your hands and skin well before using.

Pregnant women and women who are breastfeeding should not use DMSO, since little is known about its possible effects on the fetus or infant.

You should also not use DMSO without talking to your doctor if you have:

  • Diabetes
  • Asthma
  • Liver and kidney conditions

Always keep in mind that supplements are not regulated by the FDA the same was as drugs are. The manufacturer does not have to prove that a supplement is safe or effective before selling.

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Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Dimethylsulfoxide (DMSO) is a chemical that dissolves many organic and inorganic substances. It’s available as a prescription drug and dietary supplement.

DMSO helps medicines get through the skin and can affect proteins, carbohydrates, fats, and water in the body.

People use DMSO for bladderinflammation (interstitial cystitis), limb pain that usually occurs after an injury, and leakage of an IV drug from the vein into surrounding skin and tissue. It is also used for osteoarthritis, bed sores, stomach ulcers, and many other conditions, but there is no good scientific evidence to support most of these other uses.

Don’t confuse DMSO with Methylsulfonylmethane (MSM). These are not the same.

Uses & Effectiveness ?

Effective for

  • Painful bladder syndrome (interstitial cystitis). DMSO is an FDA-approved product for the treatment of this condition. Washing the bladder with DMSO improves some symptoms, such as pain.

Possibly Effective for

  • Limb pain that usually occurs after an injury (complex regional pain syndrome). Applying DMSO cream to the skin seems to improve pain in people with this condition.
  • Leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation). Some chemotherapy drugs can cause skin and tissue damage if they leak from the vein. Applying DMSO to the skin might prevent further damage if this happens.

Possibly Ineffective for

  • Hardening of skin and connective tissue (scleroderma). Applying DMSO to the skin doesn’t help treat symptoms of scleroderma.

There is interest in using DMSO for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Special Precautions and Warnings

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Pregnancy and breast-feeding: There isn’t enough reliable information to know if DMSO is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Certain blood disorders. Injecting DMSO by IV might cause red blood cells to break down. This might be a problem for people with certain blood disorders. DMSO might make these conditions worse.

Kidney problems: DMSO might harm the kidneys. Check with a healthcare provider before using DMSO if you have kidney problems.

Liver problems: DMSO might harm the liver. Check with a healthcare provider before using DMSO if you have liver problems.br/>

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • DMSO can sometimes increase how much medicine the body absorbs. Applying DMSO to the skin, eyes, or ears at the same time as applying medication can increase how much medicine the body absorbs. This might increase the effects and side effects of the medicine.

  • DMSO might slow blood clotting. Taking DMSO along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

  • Using DMSO with sulindac might reduce how well sulindac works to treat pain. There is also a concern that using DMSO with sulindac can increase the risk for nerve pain.

  • DMSO can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking DMSO with these medications might increase the chance of side effects.

  • Using DMSO with verteporfin might reduce how well verteporfin works.

  • Using DMSO to dissolve platinum agents onto the skin might reduce how well these drugs work to treat cancer. Examples of platinum agents include carboplatin, cisplatin, and oxaliplatin.

Dosing

DMSO has most often been applied to the skin by adults in various forms, including creams, gels, and solutions. It is also applied inside the bladder. DMSO is available as a prescription and in dietary supplements. Speak with a healthcare provider before use.

View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

Scientists have found a way to destroy the toxic “eternal chemicals” that flooded the world – Gazeta.Ru

Scientists have found a way to destroy the toxic “eternal chemicals” that flooded the world – Gazeta.Ru | News

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Researchers have shown that a mixture of soap and DMSO solvent can break down per- and polyfluoroalkyl compounds (PFAS), known as “timeless chemicals”. Development reported Science .

Two years ago, researchers from the US Environmental Protection Agency placed a sample of PFAS in a common solvent (DMSO) to study toxicity, but the substance began to degrade. The new study builds on this observation. Scientists from Northwestern University studied various mixtures containing DMSO. The mixture of DMSO and sodium hydroxide, a common soap ingredient, showed the greatest effectiveness when heated to boiling point.

This method works with approximately 40% PFAS. Now it has to be tested on large volumes. Those compounds, the destruction of which chemists have studied, are used in fire-fighting foams and the production of non-stick coatings.

PFAS are known as “timeless chemicals” because they can remain in the environment for decades. Recently, they have even been found in rainwater in the Tibetan Plateau in quantities far exceeding safe ones. The new method will cheaply and safely cleanse the planet of potentially toxic and carcinogenic substances.

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DMSO (dimethyl sulfoxide) in the best quality pharmaceutical premium

DMSO – Universal Solvent (100 ml)

Dimethyl Sulfoxide (DMSO) is a colorless and odorless organic universal solvent used in laboratory and technical applications. Very high purity of 99.9% meets Ph.Eur certification. Depending on the application, it is easily mixed with water in any ratio. It has an amazing amount of good properties and is extremely versatile.

Benefits of using DMSO:

  • Pharmaceutical purity according to the European Pharmacopoeia

  • Integrated dropper for easy dosing

  • TÜV Rheinland tested: 100% EU-compliant

  • Filled in break-proof and child-proof HDPE bottle

  • is perfect for travel, outdoor or crisis preparedness!

  • The original, only from AQUARIUS pro life

Disadvantages compared to other DMSO solutions:

  • often no pharmaceutical safety

  • No TÜV-tested EU conformity

  • Often bottled in fragile glass bottles

  • is therefore impractical for travel and outdoor use.

Benefits of using DMSO:

  • Pharmaceutical purity according to the European Pharmacopoeia

  • Integrated dropper for easy dosing

  • TÜV Rheinland tested: 100% EU-compliant

  • Filled in break-proof and child-proof HDPE bottle

  • is perfect for travel, outdoor or crisis preparedness!

  • The original, only from AQUARIUS pro life

Disadvantages compared to other DMSO solutions:

  • often no pharmaceutical safety

  • No TÜV-tested EU conformity

  • Often bottled in fragile glass bottles

  • is therefore impractical for travel and outdoor use.

Content:

100ml 99.9% DMSO ultrapure Ph.Eur in HDPE bottle

(CAS no: 67-68-5, EC no: 200-664-3) Taric: 29091990

Storage and shelf life:

Store in a dry place at room temperature, well closed and out of the reach of children!

DMSO becomes crystalline and solid at low temperatures below 18°C, eg during transport or in winter. This is completely normal and harmless. When heated in a warm water bath, it becomes liquid again. Remove residues on fabrics and surfaces immediately with a damp cloth. DMSO is a long-term stable compound and therefore has a very long shelf life.

Areas of use:

Depending on the application, DMSO can be easily mixed with water in any ratio. Dimethyl sulfoxide has an amazing amount of good properties and is extremely versatile, being used in cosmetics, pharmaceuticals, and as a widely used solvent in laboratories and engineering, among others.

Environment protection:

The raw materials for our sustainable packaging and product information sheet come from sustainable forestry (FSC) and are printed in a climate-neutral way. Please recycle them. Our bottles, child-resistant cap and label are made from polyethylene and are recyclable.

Important note:

Use solvents safely! Always read the label and product information before use.

Keep out of reach of children.

“Glass or HDPE bottle – which is better?”.

Many suppliers use amber glass bottles and advertise that they are much safer and better protect the contents from, for example, UV rays or soluble plastic. However, the fact is that this ingredient is not sensitive to either light or UV, and HDPE (High Density Polyethylene) is a legally approved and suitable storage material. Every industrial manufacturer of DMSO produces, bottles and stores it in HDPE cans, drums or containers.

How can quality be improved by pouring into glass bottles?

Conclusion: HDPE is a legal plastic for storing DMSO and does not mix with the filler in any way. Precise drip filling is much easier with our unbreakable HDPE bottle.

That’s why we only use approved HDPE and not glass – for your safety!

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