What are the distinctive characteristics of guttate psoriasis. How does guttate psoriasis differ from other types of psoriasis. What triggers guttate psoriasis flare-ups. Can guttate psoriasis be effectively managed with treatment. How is guttate psoriasis diagnosed and treated.

Understanding Guttate Psoriasis: A Unique Form of Skin Condition

Guttate psoriasis is a distinct type of psoriasis characterized by small, teardrop-shaped, red, and scaly spots on the skin. Unlike other forms of psoriasis, guttate psoriasis typically affects children and young adults, making up less than a third of all psoriasis cases. This autoimmune condition causes the body to mistakenly attack its own cells, resulting in the characteristic skin lesions.

Is guttate psoriasis a permanent condition. While some individuals may experience a single outbreak, others may have recurring flare-ups. In certain cases, guttate psoriasis can persist, requiring ongoing management and treatment. With proper medical guidance, patients can effectively control their symptoms and improve their quality of life.

Recognizing the Symptoms of Guttate Psoriasis

Guttate psoriasis presents with distinct symptoms that set it apart from other forms of psoriasis. The hallmark signs include:

• Small, teardrop-shaped red spots
• Scaly patches on the skin
• Lesions primarily on the arms, legs, and torso
• Possible spread to face, ears, and scalp

How do guttate psoriasis lesions differ from plaque psoriasis. Guttate psoriasis spots are typically thinner and smaller than those seen in plaque psoriasis. It’s worth noting that some individuals may experience both types of psoriasis simultaneously.

Are there seasonal variations in guttate psoriasis symptoms. Many patients report more frequent flare-ups during winter months when the air is dry. Conversely, symptoms may improve during summer, possibly due to increased sun exposure.

The Stages of Guttate Psoriasis: From Mild to Severe

Guttate psoriasis can be classified into three main stages based on the extent of skin involvement:

1. Mild: Few spots covering approximately 3% of the skin
2. Moderate: Lesions affecting 3-10% of the skin surface
3. Severe: Extensive coverage of 10% or more of the body

Is the severity of guttate psoriasis solely determined by skin coverage. While the percentage of affected skin is a crucial factor, the impact on daily life and activities also plays a role in determining severity. For instance, psoriasis on visible areas like the face or scalp, even if covering a small percentage of the body, may be classified as severe due to its effect on appearance and quality of life.

Functional Impact and Severity Classification

How can psoriasis on a small area be considered severe. In some cases, the location of the lesions can significantly influence the severity classification. For example, psoriasis on the hands, even if covering only 2% of the total body surface area, could be classified as moderate to severe if it interferes with a person’s ability to work or perform daily tasks.

Unraveling the Causes and Triggers of Guttate Psoriasis

Understanding the underlying causes and triggers of guttate psoriasis is crucial for effective management and prevention of flare-ups. What is the primary trigger for guttate psoriasis outbreaks. The most common trigger is a bacterial infection, typically streptococcus (strep throat). This infection initiates an immune system reaction that leads to the characteristic skin lesions.

Is there a genetic component to guttate psoriasis. In some cases, guttate psoriasis has a genetic basis. Individuals with a family history of the condition may have an increased risk of developing it themselves.

Additional Triggers for Guttate Psoriasis

Besides strep infections, several other factors can trigger guttate psoriasis flare-ups:

• Upper respiratory infections
• Sinus infections
• Influenza
• Tonsillitis
• Psychological stress
• Skin injuries (cuts, burns, or bites)
• Certain medications (e.g., antimalarials and beta-blockers)

Diagnosing Guttate Psoriasis: A Comprehensive Approach

Accurate diagnosis of guttate psoriasis is essential for appropriate treatment and management. How do healthcare providers diagnose guttate psoriasis. The diagnostic process typically involves several steps:

1. Medical history review: The doctor will inquire about your symptoms, medical history, and any medications you’re taking.
2. Physical examination: A thorough skin examination is usually sufficient for diagnosis.
3. Blood tests: In some cases, a blood sample may be taken to rule out other conditions or check for underlying infections.
4. Throat culture: This test can help identify strep infections that may have triggered the outbreak.
5. Skin biopsy: If there’s uncertainty about the diagnosis, a small skin sample may be taken for microscopic examination.

Is a skin biopsy always necessary for diagnosing guttate psoriasis. While not always required, a skin biopsy can provide definitive confirmation of the diagnosis in cases where clinical presentation is atypical or there’s doubt about the specific type of psoriasis.

Effective Treatment Strategies for Guttate Psoriasis

Managing guttate psoriasis involves a multifaceted approach aimed at alleviating symptoms, preventing complications, and improving quality of life. How long does a typical guttate psoriasis outbreak last. In most cases, an outbreak of guttate psoriasis resolves within 2 to 3 weeks. However, treatment may be necessary to manage symptoms and prevent secondary infections.

Topical Treatments for Guttate Psoriasis

Several over-the-counter and prescription topical treatments can help manage the symptoms of guttate psoriasis:

• Cortisone creams: These help reduce itching and inflammation.
• Dandruff shampoos: Specially formulated shampoos can help manage scalp involvement.
• Coal tar lotions: These products can soothe irritated skin.
• Moisturizers: Regular moisturizing helps combat dryness and scaling.
• Prescription vitamin A derivatives: These medications can help normalize skin cell turnover.

Systemic Treatments for Severe Cases

In more severe cases of guttate psoriasis, systemic treatments may be necessary. These include:

• Oral corticosteroids
• Biologic agents (e.g., guselkumab, ixekizumab)
• Apremilast (Otezla)
• Deucravacitinib (Sotyktu)
• Methotrexate

How do biologic agents work in treating guttate psoriasis. Biologic medications target specific components of the immune system involved in the inflammatory process, helping to reduce psoriasis symptoms and prevent flare-ups.

Phototherapy: Harnessing the Power of Light

Phototherapy, or light therapy, is another effective treatment option for guttate psoriasis. This approach involves exposing the skin to controlled amounts of ultraviolet light. How is phototherapy administered for guttate psoriasis. Treatment can be delivered in a clinical setting using specialized equipment, or in some cases, carefully monitored sun exposure may be beneficial.

Are there any precautions to consider with phototherapy. While phototherapy can be highly effective, it’s important to follow medical guidance to avoid overexposure and potential skin damage. Your healthcare provider may prescribe photosensitizing medications to enhance the effectiveness of light therapy.

Living with Guttate Psoriasis: Long-Term Management and Outlook

Managing guttate psoriasis is an ongoing process that requires a combination of medical treatment and lifestyle modifications. Can guttate psoriasis be completely cured. While there is no permanent cure for guttate psoriasis, many individuals achieve long periods of remission with proper treatment and management.

Lifestyle Modifications for Guttate Psoriasis Management

Several lifestyle changes can help minimize flare-ups and improve overall skin health:

• Stress management: Practice relaxation techniques to reduce stress-induced flare-ups.
• Proper skin care: Keep skin moisturized and avoid harsh products that may irritate the skin.
• Healthy diet: Some individuals find that certain dietary changes help manage their symptoms.
• Avoid triggers: Identify and avoid personal triggers that may exacerbate your condition.
• Regular check-ups: Maintain regular appointments with your dermatologist to monitor your condition and adjust treatment as needed.

How can one identify personal triggers for guttate psoriasis. Keeping a symptom diary can help track potential triggers, such as stress, dietary factors, or environmental changes that coincide with flare-ups.

The Importance of Ongoing Medical Care

Regular medical follow-up is crucial for effective long-term management of guttate psoriasis. Your healthcare provider can:

• Monitor the effectiveness of your current treatment plan
• Adjust medications as needed
• Screen for potential complications or associated conditions
• Provide guidance on emerging treatment options

Is guttate psoriasis associated with any other health conditions. While guttate psoriasis itself is primarily a skin condition, individuals with psoriasis may have an increased risk of certain health issues, including cardiovascular disease and psoriatic arthritis. Regular medical check-ups can help detect and address these potential complications early.

Emerging Research and Future Treatments for Guttate Psoriasis

The field of psoriasis research is continuously evolving, with new treatments and management strategies on the horizon. What are some promising areas of research for guttate psoriasis treatment. Current areas of investigation include:

• Targeted immunotherapies
• Gene therapy approaches
• Microbiome-based treatments
• Personalized medicine strategies

How might personalized medicine impact guttate psoriasis treatment. Advances in genetic testing and biomarker identification may allow for more tailored treatment approaches, potentially improving efficacy and reducing side effects.

The Role of Clinical Trials in Advancing Guttate Psoriasis Treatment

Clinical trials play a crucial role in developing new treatments for guttate psoriasis. These studies help researchers evaluate the safety and efficacy of novel therapies before they become widely available. How can patients participate in guttate psoriasis clinical trials. Individuals interested in participating in clinical trials should discuss this option with their healthcare provider, who can provide information on suitable studies and potential risks and benefits.

As research progresses, the outlook for individuals with guttate psoriasis continues to improve. With ongoing advancements in treatment options and management strategies, many patients can look forward to better symptom control and improved quality of life.

Rash, Causes, Stages, Symptoms, Treatment

Written by WebMD Editorial Contributors

• What Is Guttate Psoriasis?
• Symptoms of Guttate Psoriasis
• Stages of Guttate Psoriasis
• Causes and Triggers of Guttate Psoriasis
• Diagnosis of Guttate Psoriasis
• Treatment for Guttate Psoriasis
• More

Guttate psoriasis is a type of psoriasis that shows up on your skin as red, scaly, small, teardrop-shaped spots. It doesn’t normally leave a scar. You usually get it as a child or young adult. Less than a third of people with psoriasis have this type. It’s not as common as plaque psoriasis.

It’s an autoimmune disease, meaning your body treats your own cells like invaders and attacks them. You might get it only once, or you could have several flare-ups. In some cases, this type of psoriasis doesn’t go away. With the help of your doctor, you can find a treatment to keep your symptoms under control.

The spots you get from guttate psoriasis aren’t as thick as the ones from plaque psoriasis. You can sometimes have both kinds of psoriasis at once. You probably would get them on your arms, legs, and upper body.

It can sometimes spread from there to your face, ears, and scalp. But it doesn’t show up on your palms, the soles of your feet, or nails like other forms of psoriasis can. You’re more likely to have a flare-up during the winter, when the air is dry. Your symptoms may clear up more quickly in summer.

There are three:

• Mild. Only a few spots cover about 3% of your skin.
• Moderate. Lesions cover about 3%-10% of your skin.
• Severe. Lesions cover 10% or more of your body and could cover your entire body.

The stage can also be based on how much they interfere with your daily life and activities. For example, psoriasis on your face or scalp can affect only 2%-3% of your total body surface area, but it could be classified as severe because it affects your appearance and livelihood. Psoriasis on your hands might only cover 2% total body surface area, but could affect your livelihood if you work with your hands. In that case it would be classified as moderate to severe.

An outbreak is usually triggered by a bacterial infection — typically streptococcus (strep throat). It sets off an immune system reaction that causes the spots on your skin.

In some cases, guttate psoriasis is genetic. If someone in your family has it, your chances of getting it go up.

Other triggers include:

• Upper respiratory infections
• Sinus infections
• Flu
• Tonsillitis
• Stress
• Cuts, burns, or bites on your skin
• Some drugs you take (antimalarials and beta-blockers)

Your doctor will want to know your medical history, especially what kinds of medications you may be taking. They’ll look at your skin. Usually, a physical exam gives your doctor enough information to diagnose or rule out guttate psoriasis.

If they need more information, your doctor may take a blood sample or a throat culture to check for strep. It’s also common for doctors to perform a skin biopsy when they want to know for sure what you have.

In most cases, an outbreak of guttate psoriasis lasts 2 to 3 weeks. But your doctor may want to treat your symptoms and help prevent other infections in your body.

• Medications. There are several over-the-counter or prescription options for the itchy, flaky skin, as well as the dryness and swelling. They include:
  • Cortisone cream for itching and swelling
  • Dandruff shampoo for your scalp
  • Lotions with coal tar to soothe your skin
  • Moisturizers
  • Prescription medicines with vitamin A
  • If your case is more serious, your doctor may give you a prescription to take by mouth. These include:
    • Corticosteroids
    • Biologics (guselkumab, ixekizumab)
    • Apremilast (Otezla)
    • Deucravacitib (Sotyktu)
    • Methotrexate
• Phototherapy. Also known as light therapy, this is another option. Your doctor will shine ultraviolet light onto your skin during this treatment. They may also give you medication to make your skin react more quickly to light. Sometimes, just going out into the sunshine can help.

Top Picks

Rash, Causes, Stages, Symptoms, Treatment

Written by WebMD Editorial Contributors

• What Is Guttate Psoriasis?
• Symptoms of Guttate Psoriasis
• Stages of Guttate Psoriasis
• Causes and Triggers of Guttate Psoriasis
• Diagnosis of Guttate Psoriasis
• Treatment for Guttate Psoriasis
• More

Guttate psoriasis is a type of psoriasis that shows up on your skin as red, scaly, small, teardrop-shaped spots. It doesn’t normally leave a scar. You usually get it as a child or young adult. Less than a third of people with psoriasis have this type. It’s not as common as plaque psoriasis.

It’s an autoimmune disease, meaning your body treats your own cells like invaders and attacks them. You might get it only once, or you could have several flare-ups. In some cases, this type of psoriasis doesn’t go away. With the help of your doctor, you can find a treatment to keep your symptoms under control.

The spots you get from guttate psoriasis aren’t as thick as the ones from plaque psoriasis. You can sometimes have both kinds of psoriasis at once. You probably would get them on your arms, legs, and upper body.

It can sometimes spread from there to your face, ears, and scalp. But it doesn’t show up on your palms, the soles of your feet, or nails like other forms of psoriasis can. You’re more likely to have a flare-up during the winter, when the air is dry. Your symptoms may clear up more quickly in summer.

There are three:

• Mild. Only a few spots cover about 3% of your skin.
• Moderate. Lesions cover about 3%-10% of your skin.
• Severe. Lesions cover 10% or more of your body and could cover your entire body.

The stage can also be based on how much they interfere with your daily life and activities. For example, psoriasis on your face or scalp can affect only 2%-3% of your total body surface area, but it could be classified as severe because it affects your appearance and livelihood. Psoriasis on your hands might only cover 2% total body surface area, but could affect your livelihood if you work with your hands. In that case it would be classified as moderate to severe.

An outbreak is usually triggered by a bacterial infection — typically streptococcus (strep throat). It sets off an immune system reaction that causes the spots on your skin.

In some cases, guttate psoriasis is genetic. If someone in your family has it, your chances of getting it go up.

Other triggers include:

• Upper respiratory infections
• Sinus infections
• Flu
• Tonsillitis
• Stress
• Cuts, burns, or bites on your skin
• Some drugs you take (antimalarials and beta-blockers)

Your doctor will want to know your medical history, especially what kinds of medications you may be taking. They’ll look at your skin. Usually, a physical exam gives your doctor enough information to diagnose or rule out guttate psoriasis.

If they need more information, your doctor may take a blood sample or a throat culture to check for strep. It’s also common for doctors to perform a skin biopsy when they want to know for sure what you have.

In most cases, an outbreak of guttate psoriasis lasts 2 to 3 weeks. But your doctor may want to treat your symptoms and help prevent other infections in your body.

• Medications. There are several over-the-counter or prescription options for the itchy, flaky skin, as well as the dryness and swelling. They include:
  • Cortisone cream for itching and swelling
  • Dandruff shampoo for your scalp
  • Lotions with coal tar to soothe your skin
  • Moisturizers
  • Prescription medicines with vitamin A
  • If your case is more serious, your doctor may give you a prescription to take by mouth. These include:
    • Corticosteroids
    • Biologics (guselkumab, ixekizumab)
    • Apremilast (Otezla)
    • Deucravacitib (Sotyktu)
    • Methotrexate
• Phototherapy. Also known as light therapy, this is another option. Your doctor will shine ultraviolet light onto your skin during this treatment. They may also give you medication to make your skin react more quickly to light. Sometimes, just going out into the sunshine can help.

Top Picks

Guttate psoriasis.

What is guttate psoriasis?

IMPORTANT
The information in this section should not be used for self-diagnosis or self-treatment. In case of pain or other exacerbation of the disease, only the attending physician should prescribe diagnostic tests. For diagnosis and proper treatment, you should contact your doctor.

Guttate psoriasis is a type of psoriasis, the distinguishing features of which are the absence of damage to the nail plates and the spontaneous, unpredictable spread of skin rashes associated with the presence of an infection in the body. The primary element is a pink teardrop-shaped papule. The appearance of a papule is accompanied by itching. Initially, the rash is localized on the trunk and extremities, but subsequently spreads over the entire skin, with the exception of the palms and soles. The disease is diagnosed clinically when the psoriatic triad is detected, using histological data. The most effective methods of treatment are PUVA therapy and plasmapheresis.

• Causes of guttate psoriasis
• Classification of guttate psoriasis
• Symptoms of guttate psoriasis
• Diagnosis of guttate psoriasis
• Treatment of guttate psoriasis
• Prices for treatment

General

Guttate psoriasis is a rather rare form of scaly lichen of autoimmune coloration with a chronic course. Dermatosis has no gender or racial differences, does not have a clear seasonality, and is not endemic. Most often, guttate psoriasis is diagnosed in school-age children, young men and women. In the world, more than 4% of the population suffer from psoriasis, teardrop-shaped accounts for about 2 million people. Guttate psoriasis is organ-specific, often combined with somatic pathology, acute or exacerbated chronic infections. It is assumed that such combinations are due to a violation of the protective properties of the skin and easy penetration into the body of infectious agents, which are one of the main triggers in the trigger mechanism for the development of the disease.

It is believed that disseminated guttate psoriasis shortens the life of a woman by 3 years, men – by 1.5 years. The reason for the shortening of life is autoimmune disorders. The development of guttate psoriasis is adversely affected by bad habits, especially smoking and a high atherogenic dietary profile. Smoking a pack of cigarettes a day increases the risk of guttate psoriasis by 2 times. Eating a large amount of fish (a natural source of polyunsaturated fatty acids) reduces the likelihood of the disease by 3 times. The urgency of the problem is associated with the severe course of the psoriatic process, which significantly worsens the quality of life of patients.

Guttate psoriasis

Causes of guttate psoriasis

The vast majority of dermatologists consider the main cause of the development of guttate psoriasis to be an infection of any etiology: influenza, tonsillitis, pneumonia, acute respiratory diseases of the upper respiratory tract, mucosal candidiasis. In favor of the infectious theory, the presence of pathogenic pathogens in a scraping from a teardrop-shaped plaque testifies. An infectious disease either leads to the debut of the pathology, or exacerbates the course of other forms of psoriasis and stimulates their transformation into guttate psoriasis. The background of pathological changes is stress, overwork, decreased immunity, hereditary predisposition, or a combination of several of these factors. Despite the fact that a pathogenic pathogen is determined in scrapings from plaques, guttate psoriasis is not an infectious disease, it is not contagious.

In the pathogenesis of guttate psoriasis, the leading role belongs to autoimmune reactions. The presence of infection activates the genes responsible for the development of the disease, stress affects neuropeptides that can stimulate keratinocytes, which, in turn, release cytokines. Cytokines activate lymphocytes of the immune system and histiocytes of the connective tissue component of the skin, which attract eosinophils. There are three stages in the development of guttate psoriasis: sensitization, latent existence and effector. In the first phase, the mechanism of the antigen-antibody reaction is launched, where pathogenic microorganisms that penetrate the skin act as antigens, and cells of the immune and reticuloendothelial system act as antibodies. In the second phase, there is a latent accumulation of antibodies produced by dermal cells and lymphocytes of the immune system. Antibodies, due to an overabundance, bind not only foreign particles, but also endogenous skin structures.

Finally, in the third phase, a manifest rash of primary elements begins on the surface of the skin. The time of the onset of the final phase cannot be predicted, since the duration of the latent period depends on the virulence of the pathogen or the cytotoxicity of another pathogen, its quantity and the resistance of the organism. It should be noted that in the case of guttate psoriasis, genetic predisposition does not play a decisive role, since there are many genes responsible for the development of guttate psoriasis, and the genetic transmission of any form of psoriasis does not obey Mendel’s laws. It is impossible to consider guttate psoriasis as genodermatosis, one can only speak of a genetically determined heterogeneous disease.

Guttate psoriasis classification

In dermatology, it is customary to classify guttate psoriasis according to severity, taking into account the prevalence of skin lesions. Distinguish:

Severe guttate psoriasis is a common rash that covers more than 10% of the skin. They are localized everywhere, seriously disrupt the patient’s condition, require medical intervention in a specialized hospital and treatment according to an individual program until the primary psoriatic elements completely regress.

Symptoms of guttate psoriasis

The disease has an undulating course, remissions are replaced by relapses, especially frequent in the autumn-winter period. Clinical manifestations of guttate psoriasis occur spontaneously. The primary element is a bright red teardrop-shaped papule, 3 to 10 mm in diameter, covered with a silvery scale. Papules grow along the periphery, merge and turn into plaques. When injured, the elements are prone to ulceration and transformation into exudative psoriasis. The rash is accompanied by itching. The rash is located on the trunk and limbs – this is a typical localization of the primary elements of guttate psoriasis. The face almost always remains free, the nail plates are not affected. The rash may resolve on its own or transform into a more severe form of psoriasis. The disappearance of the rash is not a guarantee of recovery.

Diagnosis of guttate psoriasis

When making a diagnosis of guttate psoriasis, data on a recent infection, complaints, and the presence of a specific diagnostic triad: stearin stain, terminal film, and dewdrop bleeding are taken into account. In the KLA, an increased ESR and leukocytosis are determined, according to biochemistry, the presence of a rheumatoid factor is detected. Children who have had a streptococcal infection are given serological tests with the detection of an increased titer of antistreptolysin-O and antideoxyribonuclease, a swab is taken from the nasopharynx with bacteriological examination for hemolytic streptococcus.

Histology is typical for drip psoriasis, morphological changes indicate the immaturity of the epidermal cells, the presence of T-lymphocytes in the biopsy, and the phenomena of hyperkeratosis. The disease is differentiated with other varieties of psoriasis, pink lichen, secondary syphilis, drug toxicoderma, dermatitis and viral exanthema.

Treatment of guttate psoriasis

Dermatosis is resistant to ongoing therapy, requires patience from both the patient and the dermatologist. The treatment is complex, depending on the severity of the process, it is carried out on an outpatient or inpatient basis. First of all, sanation of foci of chronic infection is carried out, residual effects of acute forms of acute respiratory infections and acute respiratory viral infections are treated, and concomitant somatic pathology is corrected. The dermatologist selects an individual program of anti-atherogenic nutrition profile with the use of polyunsaturated fatty acids. Simultaneously carry out symptomatic therapy. For guttate psoriasis, PUVA therapy is most effective when given in small doses under medical supervision. The use of plasmapheresis can reduce the frequency of relapses.

Medications for guttate psoriasis are used for different purposes and according to different therapeutic regimens. For example, hormonal ointments, taking into account the area of ​​\u200b\u200bdamage to the skin, are used only in short courses; Antibacterial therapy against the inoculated hemolytic streptococcus is carried out by prescribing long cycles of antibiotic therapy using cephalosporins. The longest time is the intake of immunomodulators.

Vitamin therapy (A, D, C, E, group B) and preparations containing monoclonal antibodies are shown. If the growths of the primary elements are significant and continue to progress, retinoids are used internally and ointments with calcitriol externally. Assign sedative, antipruritic and antihistamine therapy. Baths with bran give a good effect. The prognosis is relatively favorable, taking into account the undulating course of guttate psoriasis and a decrease in the quality of life of patients.

You can share your medical history, what helped you in the treatment of guttate psoriasis.

Sources

1. self-treatment. In case of pain or other exacerbation of the disease, only the attending physician should prescribe diagnostic tests. For diagnosis and proper treatment, you should contact your doctor.

   Treatment of acute guttate psoriasis in addition to drugs directed against streptococcal infection

   Survey question

   The purpose of this review is to find out how well different non-streptococcal agents (i.e. drugs that do not target streptococcal infection) work for acute guttate psoriasis or guttate flare-ups of chronic psoriasis in adults and children, and how safe they are compared with placebo (identical but inactive agent) or other treatment. This topic is important because there is a lack of information and evidence regarding the best way to treat guttate psoriasis. We collected and analyzed all relevant studies to answer this question and found one study.

   Relevance

   Psoriasis is a chronic skin disease characterized by red, scaly patches (known as plaques). About 2% of people suffer from psoriasis. Guttate psoriasis is characterized by smaller lesions and is more common in children and young adults. Treatment for guttate psoriasis aims to clear the skin of lesions for as long as possible and includes topical (applied to the skin) or oral (taken by mouth) drugs, phototherapy (i.e., ultraviolet light therapy), and biologics (through which a living the body produces the active substance). It is not known which of these options is better at eliminating lesions in guttate psoriasis, and whether they are safe.

   Study profile

   We found one relevant study comparing the effects of intravenous injections of two different lipid (fat) emulsions twice a day for 10 days: one emulsion (two or more liquids that often do not mix) was derived from fish oil, and the other is from soybean oil. The follow-up period for participants was 40 days. The study was conducted in Germany among 21 adults (18 men and 3 women) aged 21 to 65 years. The average area of ​​skin lesions was 25%. Participants were hospitalized for acute guttate psoriasis. The study was funded by an oil emulsion company.

   Main results

   Treatment options for which we did not find evidence include phototherapy and topical, oral, and biologic agents. The only study found did not assess two main outcomes: the percentage of treated people whose skin cleared (or nearly cleared) of lesions, and side effects or harm from treatment.

   Most secondary outcomes were also not assessed, including worsening of guttate psoriasis or recurrence within six months of completing treatment, and the percentage of participants who achieved a Psoriasis Area and Severity Index of 75 or a Physician’s Overall Score of 1 or 2. The included study did not report about the assessment of harm from treatment; however, the study authors reported rare skin irritation at the injection site, but did not state the number of participants who experienced it.

   Study participants self-assessed several outcomes, including skin lesions, impact on daily life, itching, burning and pain.