How does phentermine aid in weight loss. What are the common side effects of phentermine. Is phentermine safe for long-term use. What precautions should be taken when using phentermine. How effective is phentermine for obesity treatment.

Understanding Phentermine: An Overview of the Weight Loss Medication

Phentermine is a prescription medication primarily used for short-term treatment of obesity. It belongs to a class of drugs called anorectics, which work by suppressing appetite. Available in oral capsule, tablet, and orally disintegrating tablet forms, phentermine is typically prescribed alongside lifestyle modifications such as exercise and a low-calorie diet to promote weight loss in individuals with certain health risk factors.

The brand name for phentermine is Adipex-P, though generic versions are also available. As a controlled substance, its use is closely monitored by healthcare providers due to its potential for misuse and dependence.

How Does Phentermine Work?

The exact mechanism of action for phentermine is not fully understood. However, it is believed to work by increasing the release of certain neurotransmitters in the brain that help reduce appetite. This appetite suppression may lead to reduced calorie intake, ultimately contributing to weight loss when combined with other lifestyle changes.

Phentermine Usage and Dosage Guidelines

Phentermine is prescribed for short-term use, typically a few weeks, as part of a comprehensive weight loss program. It is intended for individuals who are very obese or overweight and have specific health risk factors such as high blood pressure, high cholesterol, or diabetes.

Who Should Consider Phentermine?

Phentermine may be recommended for adults with a body mass index (BMI) of 30 or greater (obese) or those with a BMI of 27 or greater (overweight) who have at least one weight-related health condition. It’s crucial to note that phentermine is not suitable for everyone, and a thorough medical evaluation is necessary before starting this medication.

Proper Dosage and Administration

The dosage of phentermine varies depending on the individual’s needs and response to the medication. Typically, it is taken once daily, usually before breakfast or 1-2 hours after breakfast. It’s important to follow the prescribed dosage and not to increase or decrease the amount without consulting a healthcare provider.

Common Side Effects of Phentermine

While phentermine can be effective for weight loss, it may cause various side effects. Understanding these potential effects is crucial for anyone considering or currently taking this medication.

Mild Side Effects

• Bad taste in the mouth
• Constipation
• Diarrhea
• Dry mouth
• Headache
• Vomiting

These side effects are generally mild and may subside within a few days to weeks. If they persist or worsen, it’s important to consult with a healthcare provider.

Can phentermine cause constipation?

Yes, constipation is one of the common side effects associated with phentermine use. While not everyone experiences this side effect, it’s important to be aware of it. Staying hydrated, maintaining a balanced diet rich in fiber, and regular physical activity can help alleviate constipation symptoms. If constipation persists or becomes severe, consult your healthcare provider for guidance.

Serious Side Effects and Warnings

While less common, phentermine can cause serious side effects that require immediate medical attention. These include:

Primary Pulmonary Hypertension (PPH)

PPH is a rare but potentially fatal lung disease that can be caused by phentermine. Symptoms may include:

• Shortness of breath
• Heart palpitations
• Dizziness
• Bluish discoloration of lips and skin
• Fatigue
• Swelling in legs and ankles

Valvular Heart Disease

Phentermine may cause damage to heart valves, leading to improper valve closure and potential leakage. Signs of valvular heart disease can include:

• Fatigue and weakness
• Shortness of breath
• Swelling in legs and ankles
• Chest pain or discomfort
• Irregular heartbeat

If any of these symptoms occur, it’s crucial to seek immediate medical attention.

Interactions and Precautions

Phentermine can interact with various medications, vitamins, and herbs. It’s essential to inform your healthcare provider about all substances you’re taking before starting phentermine treatment.

What medications should not be taken with phentermine?

Phentermine should not be taken with certain medications, including:

• Monoamine oxidase inhibitors (MAOIs)
• Other weight loss medications
• Certain antidepressants
• Stimulant medications

Always consult your healthcare provider or pharmacist about potential drug interactions before starting phentermine.

Special Precautions

Certain individuals should exercise caution or avoid using phentermine altogether, including:

• Pregnant or breastfeeding women
• People with a history of drug or alcohol abuse
• Individuals with cardiovascular disease
• Those with thyroid problems
• People with glaucoma

Effectiveness of Phentermine for Weight Loss

Phentermine can be an effective tool for weight loss when used as part of a comprehensive program that includes dietary changes and increased physical activity. However, its effectiveness can vary among individuals.

How much weight can you lose with phentermine?

The amount of weight loss achieved with phentermine can vary significantly. On average, individuals may lose 5-10% of their initial body weight over 12 weeks when combining phentermine with lifestyle changes. However, it’s important to note that weight loss results can differ based on various factors, including adherence to diet and exercise recommendations, individual metabolism, and other health conditions.

Long-term Effectiveness

Phentermine is intended for short-term use only, typically up to 12 weeks. The long-term effectiveness of phentermine for weight management has not been well-established. Maintaining weight loss after discontinuing phentermine often requires continued adherence to healthy lifestyle habits.

Alternatives to Phentermine for Weight Loss

While phentermine can be effective for some individuals, it’s not suitable for everyone. There are several alternatives available for those seeking weight loss solutions:

Other Prescription Weight Loss Medications

• Orlistat (Xenical)
• Liraglutide (Saxenda)
• Naltrexone-bupropion (Contrave)
• Phentermine-topiramate (Qsymia)

Non-Pharmaceutical Approaches

Many individuals achieve successful weight loss through non-pharmaceutical methods, including:

• Calorie-restricted diets
• Increased physical activity
• Behavioral therapy
• Lifestyle modifications
• Bariatric surgery (for severe obesity)

It’s essential to consult with a healthcare provider to determine the most appropriate weight loss strategy based on individual health status, preferences, and goals.

Monitoring and Follow-up While Taking Phentermine

Regular monitoring is crucial when taking phentermine to ensure its effectiveness and minimize potential risks. This typically involves:

Regular Check-ups

Periodic visits to your healthcare provider allow for assessment of weight loss progress, evaluation of side effects, and adjustment of treatment plans if necessary.

Blood Pressure Monitoring

Phentermine can affect blood pressure, so regular monitoring is important, especially for individuals with a history of hypertension.

Heart Health Evaluation

Due to the potential risk of heart valve problems, your doctor may recommend periodic heart evaluations, which may include echocardiograms.

Mental Health Assessment

Phentermine can sometimes affect mood and mental health. Regular assessment of these aspects is important, especially for individuals with a history of mental health conditions.

Lifestyle Modifications to Enhance Phentermine Effectiveness

To maximize the benefits of phentermine and promote sustainable weight loss, certain lifestyle modifications are crucial:

Balanced, Calorie-Controlled Diet

A nutritious, calorie-restricted diet is essential for weight loss. This typically involves:

• Increased consumption of fruits, vegetables, and whole grains
• Lean protein sources
• Limited intake of processed foods, sugary drinks, and high-fat items
• Portion control

Regular Physical Activity

Incorporating regular exercise into your routine can enhance weight loss efforts and provide numerous health benefits. Aim for:

• At least 150 minutes of moderate-intensity aerobic activity per week
• Strength training exercises at least twice a week
• Increased daily movement (e.g., taking stairs, walking more)

Stress Management

Stress can impact weight loss efforts and overall health. Implementing stress-reduction techniques such as meditation, yoga, or deep breathing exercises can be beneficial.

Adequate Sleep

Proper sleep is crucial for weight management and overall health. Aim for 7-9 hours of quality sleep per night.

By combining these lifestyle modifications with phentermine use under medical supervision, individuals may achieve more significant and sustainable weight loss results.

Side Effects, Dosage, Uses, and More

Highlights for phentermine

1. Phentermine oral capsule is available as a brand-name drug and as a generic drug. Brand name: Adipex-P.
2. Phentermine comes in three forms: an oral capsule, an oral tablet, and an orally disintegrating tablet.
3. Phentermine oral capsule is used to treat obesity.

• Primary pulmonary hypertension (PPH) warning: This drug can cause PPH. This is a rare lung disease that may be fatal (cause death). PPH is a type of high blood pressure that affects the arteries in your lungs and the right side of your heart. Symptoms can include shortness of breath, heart palpitations (fast, fluttering heartbeat), dizziness, bluish color to your lips and skin, tiredness, and edema (swelling of your legs and ankles).
• Valvular heart disease warning: This drug may harm your heart valves. Your valves may not be able to close properly and may leak. This may interrupt the blood flow through your heart to your body. Symptoms can include fatigue and weakness, shortness of breath during activity or when you lie down, swollen ankles and feet, chest pain, and an irregular or fast heartbeat.
• Misuse and dependence warning: This drug may be habit-forming. You shouldn’t take it long-term. Tell your doctor if you have a history of drug or alcohol misuse before starting this drug.

Phentermine is a prescription drug. It comes as an oral capsule, an oral tablet, and an orally disintegrating tablet.

Phentermine oral capsule is available as the brand-name drug Adipex-P. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Phentermine is a controlled substance. Your use of this drug will be closely monitored by your doctor.

Why it’s used

Phentermine oral capsule is only used short-term (for a few weeks) to treat obesity. This drug aids in weight loss in very obese and overweight people with certain health risk factors. These risk factors include high blood pressure, high cholesterol, and diabetes. This drug is used along with exercise, a low-calorie diet, and other behavior changes to lose weight.

How it works

Phentermine belongs to a class of drugs called anorectics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

It isn’t known exactly how phentermine works to help you lose weight. It may work by increasing the release of chemicals in your brain that help reduce your appetite. This may help you eat less, which would aid in weight loss.

Phentermine oral capsule doesn’t cause drowsiness, but it can cause trouble sleeping. It can also cause other side effects.

More common side effects

The more common side effects of phentermine can include:

• bad taste in your mouth
• constipation
• diarrhea
• dry mouth
• headache
• vomiting

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Primary pulmonary hypertension (PPH). This is a type of high blood pressure that affects the arteries in your lungs and the right side of your heart. Symptoms can include:
  • shortness of breath
  • heart palpitations (fast, fluttering heartbeat)
  • dizziness
  • cyanosis (bluish color to your lips and skin)
  • tiredness
  • edema (swelling of your legs and ankles)
  • angina (chest pain)
• Valvular heart disease. This drug may harm your heart valves so they can’t close properly and may leak. Symptoms can include:
  • fatigue and weakness, especially when you increase your activity level
  • shortness of breath during activity or when you lie down
  • edema (swelling of your legs and ankles)
  • angina (chest pain), chest discomfort or tightness that often gets worse during exercise
  • lightheadedness or fainting
  • arrhythmia (irregular heartbeat)
  • heart murmur
  • heart palpitations (fast, fluttering heartbeat)
• Hypertension (high blood pressure)
• Restlessness
• Tremors (uncontrollable rhythmic movement in one part of your body)
• Insomnia (trouble sleeping)
• Erectile dysfunction in men (trouble getting or keeping an erection)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Phentermine oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with phentermine are listed below.

Drugs you shouldn’t take

Taking certain drugs with phentermine may cause serious side effects. Don’t take these drugs with phentermine. Examples of these drugs include:

• Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, rasagiline, selegiline, and tranylcypromine. You shouldn’t take phentermine within 14 days of starting or stopping an MAOI. Taking these drugs together can cause a hypertensive crisis (a dangerous increase in blood pressure).
• Other drugs for weight loss, such as amphetamine, benzphetamine, dextroamphetamine, diethylpropion, and phendimetrazine. Taking these drugs together may cause increased side effects. These include hypertensive crisis (a dangerous increase in blood pressure) or arrhythmia (a serious abnormal heart rhythm).
• Serotonin reuptake inhibitors (SSRIs), such as fluoxetine, sertraline, fluvoxamine, paroxetine, citalopram, escitalopram and nefazodone. Taking these drugs together can cause a hypertensive crisis (a dangerous increase in blood pressure).

Interactions that cause more side effects

Taking phentermine with certain medications may cause more side effects. Examples of these drugs include:

• Insulin and oral diabetes drugs, such as nateglinide, pioglitazone, repaglinide, rosiglitazone, metformin, glimepiride, glipizide, sitagliptin, saxagliptin, linagliptin, exenatide, and liraglutide. Taking these drugs together may cause a significant drop in your blood sugar levels. Your doctor may lower your dosage of your diabetes drugs. You may also need to monitor your blood sugar levels closely.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

Phentermine can cause a severe allergic reaction. Symptoms can include:

• trouble breathing
• swelling of your throat or tongue

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it or phendimetrazine tartrate. Taking it again could be fatal (cause death).

Alcohol interaction warning

The use of drinks that contain alcohol can increase your risk of side effects from phentermine. These side effects can include dizziness, feeling nervous and excitable, headache, hard stools or diarrhea, dry mouth, and not being able to sleep. They can also include decreased interest in sex or change in ability to have sex.

If you drink alcohol, talk to your doctor. You may need to be more closely monitored for side effects.

Warnings for people with certain health conditions

For people with history of primary pulmonary hypertension (PPH): You shouldn’t take phentermine. Phentermine may make your PPH worse.

For people with history of heart disease: You shouldn’t take this drug if you have a history of heart problems. These include stroke, arrhythmia (irregular heartbeat), heart failure, coronary artery disease, valve disease, and uncontrolled high blood pressure. Phentermine may cause a serious increase in your blood pressure. This may make your heart work harder. The extra stress on your heart may make your heart disease worse.

For people with history of hyperthyroidism: Tell your doctor if you have hyperthyroidism (an overactive thyroid). Phentermine may increase your thyroid activity. This may raise your thyroid levels even further.

For people with glaucoma: This drug may increase your eye pressure even more. This may cause permanent damage to your vision. Tell your doctor if you have glaucoma.

For people with diabetes: You may be able to control your diabetes better as you lose weight while you’re on this drug. Your doctor may lower the dosage of your diabetes drugs.

For people with a history of drug misuse: This drug may be habit-forming. You shouldn’t take this medication long-term. Tell your doctor if you have a history of drug or alcohol misuse.

For people with agitation: This drug may cause restlessness and anxiety and may make your agitation worse. You shouldn’t take phentermine if you’re agitated.

Warnings for other groups

For pregnant women: Phentermine is a category X pregnancy drug. That means two things:

1. Category X drugs should never be used during pregnancy.
2. Women of childbearing age should use reliable birth control while taking this drug.

Stop taking phentermine and call your doctor right away if you become pregnant while taking this drug.

When to call the doctor

• Call your doctor if you’re not losing weight, even though you’re exercising, eating a low-calorie diet, and taking this drug. Keep in mind that it may take a few weeks for this drug to work.

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For women who are breastfeeding: Phentermine may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

For children: This medication hasn’t been studied in children. It shouldn’t be used in people younger than 16 years.

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Drug forms and strengths

Generic: Phentermine

• Form: oral capsule
• Strengths: 15 mg, 30 mg, 37. 5 mg

Brand: Adipex-P

• Form: oral capsule
• Strengths: 37.5 mg

Dosage for obesity

Adult dosage (ages 18–64 years)

• Adipex-P and generic phentermine 37.5-mg capsule:
  • Typical starting dosage: One 37.5-mg capsule each day. Take it in the morning before breakfast, or 1–2 hours after breakfast.
  • Maximum dosage: 37.5 mg per day
• Phentermine 15-mg and 30-mg capsules:
  • Typical starting dosage: One 15-mg or 30-mg capsule each day. Take it in the morning, 2 hours after breakfast.
  • Dosage increases: If your doctor started you on 15-mg dose, they may increase your dose based on your weight loss and how well you tolerate the drug.
  • Maximum dosage: 30 mg per day.

Child dosage (age 16–17 years)

• Adipex-P and generic phentermine 37. 5-mg capsule:
  • Typical starting dosage: One 37.5-mg capsule each day. Take it in the morning before breakfast, or 1–2 hours after breakfast.
  • Maximum dosage: 37.5 mg per day.
• Phentermine 15-mg and 30-mg capsules:
  • Typical starting dosage: One 15-mg or 30-mg capsule each day. Take it in the morning, 2 hours after breakfast.
  • Dosage increases: If your doctor started you on a 15-mg dose, they may increase your dose based on your weight loss and how well you tolerate the drug.
  • Maximum dosage: 30 mg per day.

Child dosage (ages 0–16 years)

It hasn’t been confirmed that this drug is safe and effective for use in children younger than 16 years. It shouldn’t be used in children in this age range.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Phentermine oral capsule is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all: You may not lose weight. If you take this drug for a long period of time and stop it suddenly, you may have extreme fatigue and depression.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• restlessness
• tremor
• confusion
• fast breathing
• hallucinations (seeing or hearing something that isn’t there)
• arrhythmia (irregular heartbeat)
• hypertension (high blood pressure)
• heart palpitations (fast, fluttering heartbeat)
• nausea
• vomiting
• diarrhea

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: You should lose weight.

Keep these considerations in mind if your doctor prescribes phentermine for you.

General

• You can take phentermine with or without food.
• Take phentermine once per day in the morning. Taking phentermine late in the day may cause trouble sleeping.
• Don’t cut or crush the oral capsule.

Storage

• Store phentermine at room temperature. Keep it at a temperature between 68°F and 77°F (20°C and 25°C).
• Keep this drug away from light.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t harm your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

Your doctor will have you participate in an exercise program and follow a reduced-calorie diet while you’re taking this drug. This should help you lose weight. Your doctor may also ask you to keep a journal of your food intake, exercise, and weight. This will help track your weight loss progress.

Clinical monitoring

Your weight and waist circumference will be monitored while you’re taking this drug. This will tell you and your doctor if the medication is working to help you lose weight.

During your treatment, you and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include blood pressure.

Your diet

You should follow a reduced-calorie diet as directed by your doctor while taking this drug. This should help you lose weight.

Availability

Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Prior authorization

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Side Effects, Dosage, Uses, and More

Highlights for phentermine

1. Phentermine oral capsule is available as a brand-name drug and as a generic drug. Brand name: Adipex-P.
2. Phentermine comes in three forms: an oral capsule, an oral tablet, and an orally disintegrating tablet.
3. Phentermine oral capsule is used to treat obesity.

• Primary pulmonary hypertension (PPH) warning: This drug can cause PPH. This is a rare lung disease that may be fatal (cause death). PPH is a type of high blood pressure that affects the arteries in your lungs and the right side of your heart. Symptoms can include shortness of breath, heart palpitations (fast, fluttering heartbeat), dizziness, bluish color to your lips and skin, tiredness, and edema (swelling of your legs and ankles).
• Valvular heart disease warning: This drug may harm your heart valves. Your valves may not be able to close properly and may leak. This may interrupt the blood flow through your heart to your body. Symptoms can include fatigue and weakness, shortness of breath during activity or when you lie down, swollen ankles and feet, chest pain, and an irregular or fast heartbeat.
• Misuse and dependence warning: This drug may be habit-forming. You shouldn’t take it long-term. Tell your doctor if you have a history of drug or alcohol misuse before starting this drug.

Phentermine is a prescription drug. It comes as an oral capsule, an oral tablet, and an orally disintegrating tablet.

Phentermine oral capsule is available as the brand-name drug Adipex-P. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Phentermine is a controlled substance. Your use of this drug will be closely monitored by your doctor.

Why it’s used

Phentermine oral capsule is only used short-term (for a few weeks) to treat obesity. This drug aids in weight loss in very obese and overweight people with certain health risk factors. These risk factors include high blood pressure, high cholesterol, and diabetes. This drug is used along with exercise, a low-calorie diet, and other behavior changes to lose weight.

How it works

Phentermine belongs to a class of drugs called anorectics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

It isn’t known exactly how phentermine works to help you lose weight. It may work by increasing the release of chemicals in your brain that help reduce your appetite. This may help you eat less, which would aid in weight loss.

Phentermine oral capsule doesn’t cause drowsiness, but it can cause trouble sleeping. It can also cause other side effects.

More common side effects

The more common side effects of phentermine can include:

• bad taste in your mouth
• constipation
• diarrhea
• dry mouth
• headache
• vomiting

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Primary pulmonary hypertension (PPH). This is a type of high blood pressure that affects the arteries in your lungs and the right side of your heart. Symptoms can include:
  • shortness of breath
  • heart palpitations (fast, fluttering heartbeat)
  • dizziness
  • cyanosis (bluish color to your lips and skin)
  • tiredness
  • edema (swelling of your legs and ankles)
  • angina (chest pain)
• Valvular heart disease. This drug may harm your heart valves so they can’t close properly and may leak. Symptoms can include:
  • fatigue and weakness, especially when you increase your activity level
  • shortness of breath during activity or when you lie down
  • edema (swelling of your legs and ankles)
  • angina (chest pain), chest discomfort or tightness that often gets worse during exercise
  • lightheadedness or fainting
  • arrhythmia (irregular heartbeat)
  • heart murmur
  • heart palpitations (fast, fluttering heartbeat)
• Hypertension (high blood pressure)
• Restlessness
• Tremors (uncontrollable rhythmic movement in one part of your body)
• Insomnia (trouble sleeping)
• Erectile dysfunction in men (trouble getting or keeping an erection)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Phentermine oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with phentermine are listed below.

Drugs you shouldn’t take

Taking certain drugs with phentermine may cause serious side effects. Don’t take these drugs with phentermine. Examples of these drugs include:

• Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, rasagiline, selegiline, and tranylcypromine. You shouldn’t take phentermine within 14 days of starting or stopping an MAOI. Taking these drugs together can cause a hypertensive crisis (a dangerous increase in blood pressure).
• Other drugs for weight loss, such as amphetamine, benzphetamine, dextroamphetamine, diethylpropion, and phendimetrazine. Taking these drugs together may cause increased side effects. These include hypertensive crisis (a dangerous increase in blood pressure) or arrhythmia (a serious abnormal heart rhythm).
• Serotonin reuptake inhibitors (SSRIs), such as fluoxetine, sertraline, fluvoxamine, paroxetine, citalopram, escitalopram and nefazodone. Taking these drugs together can cause a hypertensive crisis (a dangerous increase in blood pressure).

Interactions that cause more side effects

Taking phentermine with certain medications may cause more side effects. Examples of these drugs include:

• Insulin and oral diabetes drugs, such as nateglinide, pioglitazone, repaglinide, rosiglitazone, metformin, glimepiride, glipizide, sitagliptin, saxagliptin, linagliptin, exenatide, and liraglutide. Taking these drugs together may cause a significant drop in your blood sugar levels. Your doctor may lower your dosage of your diabetes drugs. You may also need to monitor your blood sugar levels closely.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

Phentermine can cause a severe allergic reaction. Symptoms can include:

• trouble breathing
• swelling of your throat or tongue

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it or phendimetrazine tartrate. Taking it again could be fatal (cause death).

Alcohol interaction warning

The use of drinks that contain alcohol can increase your risk of side effects from phentermine. These side effects can include dizziness, feeling nervous and excitable, headache, hard stools or diarrhea, dry mouth, and not being able to sleep. They can also include decreased interest in sex or change in ability to have sex.

If you drink alcohol, talk to your doctor. You may need to be more closely monitored for side effects.

Warnings for people with certain health conditions

For people with history of primary pulmonary hypertension (PPH): You shouldn’t take phentermine. Phentermine may make your PPH worse.

For people with history of heart disease: You shouldn’t take this drug if you have a history of heart problems. These include stroke, arrhythmia (irregular heartbeat), heart failure, coronary artery disease, valve disease, and uncontrolled high blood pressure. Phentermine may cause a serious increase in your blood pressure. This may make your heart work harder. The extra stress on your heart may make your heart disease worse.

For people with history of hyperthyroidism: Tell your doctor if you have hyperthyroidism (an overactive thyroid). Phentermine may increase your thyroid activity. This may raise your thyroid levels even further.

For people with glaucoma: This drug may increase your eye pressure even more. This may cause permanent damage to your vision. Tell your doctor if you have glaucoma.

For people with diabetes: You may be able to control your diabetes better as you lose weight while you’re on this drug. Your doctor may lower the dosage of your diabetes drugs.

For people with a history of drug misuse: This drug may be habit-forming. You shouldn’t take this medication long-term. Tell your doctor if you have a history of drug or alcohol misuse.

For people with agitation: This drug may cause restlessness and anxiety and may make your agitation worse. You shouldn’t take phentermine if you’re agitated.

Warnings for other groups

For pregnant women: Phentermine is a category X pregnancy drug. That means two things:

1. Category X drugs should never be used during pregnancy.
2. Women of childbearing age should use reliable birth control while taking this drug.

Stop taking phentermine and call your doctor right away if you become pregnant while taking this drug.

When to call the doctor

• Call your doctor if you’re not losing weight, even though you’re exercising, eating a low-calorie diet, and taking this drug. Keep in mind that it may take a few weeks for this drug to work.

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For women who are breastfeeding: Phentermine may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

For children: This medication hasn’t been studied in children. It shouldn’t be used in people younger than 16 years.

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Drug forms and strengths

Generic: Phentermine

• Form: oral capsule
• Strengths: 15 mg, 30 mg, 37. 5 mg

Brand: Adipex-P

• Form: oral capsule
• Strengths: 37.5 mg

Dosage for obesity

Adult dosage (ages 18–64 years)

• Adipex-P and generic phentermine 37.5-mg capsule:
  • Typical starting dosage: One 37.5-mg capsule each day. Take it in the morning before breakfast, or 1–2 hours after breakfast.
  • Maximum dosage: 37.5 mg per day
• Phentermine 15-mg and 30-mg capsules:
  • Typical starting dosage: One 15-mg or 30-mg capsule each day. Take it in the morning, 2 hours after breakfast.
  • Dosage increases: If your doctor started you on 15-mg dose, they may increase your dose based on your weight loss and how well you tolerate the drug.
  • Maximum dosage: 30 mg per day.

Child dosage (age 16–17 years)

• Adipex-P and generic phentermine 37. 5-mg capsule:
  • Typical starting dosage: One 37.5-mg capsule each day. Take it in the morning before breakfast, or 1–2 hours after breakfast.
  • Maximum dosage: 37.5 mg per day.
• Phentermine 15-mg and 30-mg capsules:
  • Typical starting dosage: One 15-mg or 30-mg capsule each day. Take it in the morning, 2 hours after breakfast.
  • Dosage increases: If your doctor started you on a 15-mg dose, they may increase your dose based on your weight loss and how well you tolerate the drug.
  • Maximum dosage: 30 mg per day.

Child dosage (ages 0–16 years)

It hasn’t been confirmed that this drug is safe and effective for use in children younger than 16 years. It shouldn’t be used in children in this age range.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Phentermine oral capsule is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all: You may not lose weight. If you take this drug for a long period of time and stop it suddenly, you may have extreme fatigue and depression.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• restlessness
• tremor
• confusion
• fast breathing
• hallucinations (seeing or hearing something that isn’t there)
• arrhythmia (irregular heartbeat)
• hypertension (high blood pressure)
• heart palpitations (fast, fluttering heartbeat)
• nausea
• vomiting
• diarrhea

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: You should lose weight.

Keep these considerations in mind if your doctor prescribes phentermine for you.

General

• You can take phentermine with or without food.
• Take phentermine once per day in the morning. Taking phentermine late in the day may cause trouble sleeping.
• Don’t cut or crush the oral capsule.

Storage

• Store phentermine at room temperature. Keep it at a temperature between 68°F and 77°F (20°C and 25°C).
• Keep this drug away from light.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t harm your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

Your doctor will have you participate in an exercise program and follow a reduced-calorie diet while you’re taking this drug. This should help you lose weight. Your doctor may also ask you to keep a journal of your food intake, exercise, and weight. This will help track your weight loss progress.

Clinical monitoring

Your weight and waist circumference will be monitored while you’re taking this drug. This will tell you and your doctor if the medication is working to help you lose weight.

During your treatment, you and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include blood pressure.

Your diet

You should follow a reduced-calorie diet as directed by your doctor while taking this drug. This should help you lose weight.

Availability

Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Prior authorization

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Diet pills: benefits, contraindications and types

Many people have serious health problems due to their weight. Despite trying to diet or exercise, there are those who prefer to try diet pills to lose weight faster. But is it true that they work?

Index

• 1 How do they work?
• 2 Who can take them?
• 3 possible benefits
  • 3.1 Catalyze the effects of diet and exercise
  • 3.2 They can make a difference
  • 3.3 Increase basal metabolism
  • 3.4 They make us active and energetic
• 4 Efectos secundarios
• 5 slimming drugs

9 0007 6 other diet pills

• 6.1 garcinia cambogia extract
• 6.2 Green coffee bean extract
• 6.3 caffeine
• 6.4 Psynephrine
• 6.5 Raspberry ketones

How do they work?

There are many possible solutions to lose weight. Some options are more popular than others, including certain pills, medications, and natural supplements. They claim to help us lose weight, or at least facilitate weight loss when combined with other methods.

They typically work through one or more of the following mechanisms:

• reduce appetite by making us feel full so we eat fewer calories.
• Reduce the absorption of nutrients as fat, which makes us eat fewer calories.
• Increasing fat burning by making us burn more calories.

It is important to note that some of these treatments have some scientific basis and some may have serious health consequences. We should always discuss any dietary or supplementation changes with a physician or registered dietitian.

Prescription weight loss drugs approved for long-term use (greater than 12 weeks) cause significant weight loss compared to placebo. The combination of weight loss medications and lifestyle changes results in greater weight loss compared to lifestyle changes alone.

Over the course of a year, this could mean a weight loss of 3% to 7% of total body weight, more than we could achieve with lifestyle changes alone. It may seem like a small amount. But sustained weight loss of 5% to 10% can have important health benefits, such as reduced blood pressure, blood glucose, and triglycerides.

Who can take them?

A doctor may consider using a weight loss medication if we have not been able to lose weight through diet and exercise and we meet one of the following requirements:

• Body Mass Index (BMI) greater than 30.
• BMI is greater than 27 and we have serious obesity-related health problems such as diabetes or high blood pressure.

Your doctor will review your medical history and health problems before choosing a medicine. Then the doctor will tell us about the pros and cons of prescription drugs for weight loss. It is important to note that diet pills are not for everyone. For example, prescription weight loss drugs should not be used if we are trying to get pregnant, pregnant or breastfeeding.

possible benefits

It is a misconception that diet pills alone can make a big difference in weight loss. However, there are other benefits that diet pills provide that can help us live a healthier and happier life.

Catalyze the effects of diet and exercise

Diet pills give maximum effect when combined with an effective diet and regular exercise. They are mainly used to help us shed inches and pounds faster than we could with just a good diet and regular exercise. It’s the perfect solution to lose weight just before a wedding or any other important event, or just because we think we’ve been overweight for most of our lives.

They do this by acting as an appetite suppressant, which allows us to eat less and gives us more energy. Caffeine or any other similar supplement increases our endurance and makes us train much more efficiently than without pills.

They can make a difference

Diet pills act as very effective appetite suppressants. By taking these pills, we will snack less between meals. It will also suppress the need to eat large portions at any meal.

In addition, diet pills are great for reducing body fat synthesis. This is great news for people who accumulate a lot of fat in the body from the slightest stimulants.

Naturally, we would be concerned about the effects of these pills on our kidneys. Luckily for us, they make our diuretic functions much more efficient and ensure that all waste products in our body are properly removed and toxins and the like are not stored for long periods of time.

Increase in basal metabolism

Diet pills are also known to increase the metabolic rate in our body. This causes the food we eat to be digested quickly, which also releases energy in our body very quickly and motivates us to be physically active.

If we have a lazy day and want to skip a workout, we can do so and still benefit from the fast metabolism that the body will experience as a result of taking diet pills.

They make us active and energetic

Most diet pills contain caffeine as an additive. Caffeine is perfect for keeping us on our toes, which keeps us active throughout the day.

We will have far fewer rest days as we will always have the endurance to perform physical tasks at any time of the day using a diet pill.

Efectos secundarios

The most common side effects are nausea, constipation or diarrhea. They can be reduced over time. In rare cases, serious side effects may occur. For this reason, it is important to discuss treatment options with your doctor in detail.

Diet pills can be expensive and not always covered by insurance. Many people regain some of the weight they have lost when they stop taking weight loss medications. However, adopting healthy lifestyle habits can help limit weight gain.

How long we have to take weight loss medicine depends on whether the medicine helps us lose weight. If we have lost enough weight to improve health and we have no serious side effects, the doctor may suggest that you continue taking it indefinitely.

If we do not lose at least 5% of body weight after three to six months of taking the full dose of the drug, the doctor will likely change the treatment plan and prescribe a different weight loss drug.

weight loss drugs

There are currently four drugs approved for weight loss and long-term use. Most prescription weight loss drugs reduce appetite or increase satiety. Some do both. The exception is orlistat, which prevents fat absorption.

• bupropion-naltrexone . This is a combination drug. Naltrexone is used to treat alcohol and opioid addiction. Bupropion is an antidepressant and helps to quit smoking. Like all antidepressants, bupropion contains a warning about the risk of suicide. Bupropion-naltrexone can increase blood pressure, so monitoring is necessary at the beginning of treatment. Common side effects include nausea, headache and constipation.
• Liraglutide. Liraglutide is also used to control diabetes. Unlike other weight loss drugs, liraglutide is given by injection. A common complaint from patients is that it causes nausea. Its use may be limited to vomiting.
• Orlistat . Orlistat is also available in a lower dosage without a prescription. Orlistat can cause unpleasant gastrointestinal side effects such as gas and loose stools. You must follow a low-fat diet while taking this medicine. Isolated cases of serious liver injury have been reported with orlistat. However, a causal relationship has not been established.
• phentermine topiramate . This is another combination of a weight loss drug (phentermine) and an anticonvulsant (topiramate). Phentermine can be addictive because its action is similar to that of amphetamine. Other possible side effects include increased heart rate and blood pressure, insomnia, constipation, and nervousness. Topiramate increases the risk of birth defects. Phentermine is also used by itself for weight loss. It is one of four similar weight loss drugs approved for short-term use (less than 12 weeks).

other diet pills

In addition to prescribed drugs, there are some diet pills in supplement form.

garcinia cambogia extract

This is a small green gourd-shaped fruit. The skin of the fruit contains hydroxycitric acid, the active ingredient in Garcinia Cambogia extract, which is sold as a diet pill. Research shows that it can interfere with the body’s production of a fat-producing enzyme and increase serotonin levels, which may help reduce food cravings.

Although it is generally accepted that Garcinia Cambogia is safe in the recommended amounts, studies in recent years indicate some serious side effects. In addition, hepatotoxicity or liver failure and some episodes of mania have been reported in association with garcinia cambogia.

Green coffee bean extract

Green coffee beans are simply coffee beans that have not been roasted. They contain two substances believed to help you lose weight: caffeine and chlorogenic acid. Caffeine can increase fat burning, and chlorogenic acid can slow down the breakdown of carbohydrates in the gut.

In addition, green coffee bean extract may help lower blood sugar and blood pressure. It is also rich in antioxidants. It can cause the same side effects as caffeine. The chlorogenic acid it contains can also cause diarrhea, and some people may be allergic to green coffee beans.

caffeine

Caffeine is the most consumed psychoactive substance in the world. It is found naturally in coffee, green tea, and dark chocolate, and is added to many processed foods and drinks. Because caffeine is thought to stimulate metabolism, companies often add it to commercial weight loss supplements.

One study looked at the effect of caffeine on body weight regulation by increasing energy expenditure, which basically means you burn more calories through increased fat breakdown, as well as through a process of body heat production called thermogenesis.

In some people, large amounts of caffeine can cause anxiety, insomnia, nervousness, irritability, nausea, diarrhea, and other symptoms. Caffeine is also addictive and can reduce sleep quality.

Psynephrine

A variety of orange called bitter orange contains the compound psynephrine. Psynephrine is related to ephedrine, which used to be a popular ingredient in various weight loss drugs. However, ephedrine has since been banned as a weight loss ingredient due to serious side effects.

Psynephrine works similarly to ephedrine but is less effective. It can help reduce appetite and increase fat burning. Like ephedrine, synephrine can have serious heart-related side effects. It can also be addictive.

Raspberry ketones

Raspberry ketone is the substance found in raspberries that is responsible for their characteristic smell. A synthetic version of raspberry ketones is sold as a weight loss supplement.

Raspberry ketones increase fat breakdown and increase levels of the hormone adiponectin, which is thought to be associated with weight loss. There are very few human studies of raspberry ketones, although one study looked at raspberry ketones along with several other ingredients and found a potential 2% increase in weight loss over 8 weeks compared to placebo.

However, high doses of raspberry ketones have also been associated with higher blood sugar levels and higher levels of ALT, a liver enzyme, indicating liver dysfunction.

Weight Loss Phentermine: Side Effects and Safety – Drug Information, Health Education

Home >> Drug Information, Health Education >> Is Phentermine Safe for Weight Loss?

Product Information

Phentermine is a prescription diet pill that suppresses appetite. For people who are obese or have a weight-related medical condition, this appetite suppressant can be life-changing. Phentermine is effective, safe for short term use (three months), and inexpensive. For people who just want to wear their skinny jeans, phentermine will never be recommended or prescribed medically.

What is phentermine?

Phentermine is the oldest prescription weight loss pill currently used to treat obesity. It is also the drug most commonly prescribed for this purpose, although there are newer options on the market.

First, it is popular because it is effective. Studies have shown that it can lead to a loss of 5% to 10% of body weight within 12 weeks when taken as part of a treatment plan that includes a low-calorie diet and increased physical activity.

Second, it’s inexpensive, according to Caroline M. Apovian, MD, professor at Boston University School of Medicine specializing in endocrinology, diabetes, nutrition, and weight management. Many insurance companies do not pay for drugs or treatments for weight loss, despite the fact that there are many studies confirming the health risks of obesity. Phentermine may be the only viable option for people on a limited income.

Phentermine is available under the brand names Adipex-P and Lomaira.

How does phentermine help you lose weight?

Phentermine (what is phentermine?) Medical jargon for anorexia, which simply means that it suppresses hunger. This is partly due to the release of certain chemicals in the brain in the area of ​​the hypothalamus that controls appetite. Karl Nadolsky, M.D., board certified endocrinologist specializing in diabetes, metabolism, and obesity at Spectrum Health in Grand Rapids, Michigan, and Fellow of the American College of Endocrinologists (FACE).

Therefore, phentermine helps reduce appetite by acting on the central nervous system.

How long should I take phentermine?

Phentermine is approved for short term use only. The long-term safety and effectiveness of phentermine has never been studied—and never will be, according to Dr. Apovian, who explains that the rigorous studies needed would be too expensive.

Prescription discount card

Side effects of phentermine

Serious side effects are rare. The most common side effects of phentermine include:

• Rapid heartbeat
• Tingling in the arms or legs
• Dry mouth
• Insomnia
• Nervousness
• Constipation 90 008

You should not take phentermine if you have heart disease, including valvular heart disease, heart failure or high blood pressure, depression, an overactive thyroid gland, or glaucoma, or if you are pregnant, trying to conceive, or breastfeeding.

Is phentermine safe?

Phentermine is a medicine that is often slanderous. Diet pills have a risky reputation for two main reasons:

1. Phentermine is an amphetamine-like drug.

It is chemically similar to amphetamines. So the US Food and Drug Administration (FDA) classifies it as a Schedule IV drug (i.e. a substance under federal control) because of concerns about potential abuse or addiction. Dr. Nadolsky points out that phentermine no amphetamine. According to him, phentermine is safe even with long-term use. And in my practice, I have never seen or heard of problems with phentermine.

2. Phentermine was half of the drug fen-fen.

In the 1990s, doctors prescribed phentermine with fenfluramine or dexfenfluramine, the combination of which was nicknamed fen-fen. Fen-fen turned into a weight loss miracle craze until the FDA realized in 1997 that fenfluramine and dexfenfluramine caused serious heart problems and took them off the market.