Effect of advil. Advil Side Effects: Understanding the Risks and Benefits of Ibuprofen

13.04.202128.07.2023 by alexxlab

What are the common side effects of Advil. How does ibuprofen affect the body. Can Advil cause serious health complications. What precautions should be taken when using ibuprofen. When should you avoid taking Advil.

Содержание

What is Advil and How Does It Work?

Advil is a brand name for ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) widely used for pain relief and fever reduction. Ibuprofen works by inhibiting the production of prostaglandins, hormone-like substances that contribute to inflammation, pain, and fever in the body.

The primary uses of Advil include:

Relieving headaches
Easing toothaches
Alleviating menstrual cramps
Reducing backaches
Soothing muscle aches

By temporarily reducing prostaglandin production, Advil helps to decrease inflammation and associated discomfort. This mechanism of action makes it an effective over-the-counter medication for various minor aches and pains.

Common Side Effects of Advil

While Advil is generally considered safe when used as directed, it can cause several common side effects. These effects are typically mild and often subside on their own. The most frequently reported side effects include:

Stomach pain
Heartburn
Nausea
Vomiting
Gas
Constipation
Diarrhea

Many individuals can mitigate these side effects by taking Advil with food or milk. However, if these symptoms persist or worsen, it’s advisable to consult a healthcare professional.

Serious Side Effects and Risks Associated with Advil

While less common, Advil can potentially cause more serious side effects, especially when used improperly or for extended periods. These risks include:

Cardiovascular Risks

Prolonged use of Advil may increase the risk of heart attack and stroke. This risk is heightened in individuals who:

Have pre-existing cardiovascular conditions
Have clotting disorders
Take other medications affecting blood clotting

Are there ways to minimize cardiovascular risks when taking Advil? To reduce these risks, it’s crucial to use Advil only as directed and for the shortest duration necessary. Individuals with cardiovascular risk factors should consult their healthcare provider before using Advil regularly.

Kidney Function Impact

Advil can affect kidney function by altering prostaglandin production, which plays a role in maintaining proper kidney pressure and blood flow. Symptoms of decreased kidney function may include:

Increased blood pressure
Fluid retention
Dehydration
Decreased urination frequency
Dizziness

The risk of kidney-related side effects is higher in older adults, those with existing kidney disease, and individuals taking blood pressure medications.

Gastrointestinal Complications

One of the more serious potential side effects of Advil is damage to the stomach lining, which can lead to bleeding and ulcers in the stomach and intestines. This risk increases with prolonged use and is higher in individuals who:

Have a history of ulcers or gastrointestinal bleeding
Are over 60 years old
Use oral steroids or anticoagulants
Smoke
Consume alcohol regularly (more than three drinks per day)

How can you recognize signs of gastrointestinal complications from Advil? Symptoms may include severe stomach pain, bloody or tarry stools. If these occur, discontinue use and seek medical attention immediately.

Precautions and Considerations When Using Advil

To use Advil safely and effectively, consider the following precautions:

Follow recommended dosages and duration of use
Take with food or milk to reduce stomach irritation
Avoid alcohol consumption while using Advil
Consult a healthcare provider if you have pre-existing medical conditions
Be aware of potential drug interactions with other medications

Who should exercise extra caution when using Advil? Individuals with a history of gastrointestinal issues, cardiovascular problems, or kidney disease should be particularly cautious and consult their doctor before using Advil regularly.

Alternatives to Advil for Pain Relief

For those who may be at higher risk for Advil-related side effects, several alternatives exist for pain relief:

Acetaminophen (Tylenol): Effective for pain and fever, with a different mechanism of action
Topical pain relievers: Creams or gels applied directly to the affected area
Non-drug therapies: Heat/cold therapy, massage, or physical therapy
Natural remedies: Turmeric, ginger, or omega-3 fatty acids for their anti-inflammatory properties

Which alternative is most suitable depends on the individual’s specific condition and overall health status. Consulting a healthcare provider can help determine the best option.

When to Avoid Advil

Certain situations warrant avoiding Advil altogether:

During the last trimester of pregnancy
If you have a known allergy to NSAIDs
If you have severe liver or kidney disease
Before or after heart bypass surgery
If you have a history of stomach ulcers or bleeding

In these cases, alternative pain relief methods should be explored under medical supervision.

Proper Usage and Storage of Advil

To maximize the benefits and minimize risks associated with Advil:

Always read and follow the label instructions
Do not exceed the recommended dose
Store at room temperature, away from moisture and heat
Keep out of reach of children
Check expiration dates and dispose of expired medication properly

How long can Advil be safely used for acute pain? For most acute pain conditions, Advil should not be used for more than 10 days without consulting a healthcare provider.

Recognizing and Responding to Advil Overdose

While rare, Advil overdose can occur, especially if the medication is misused. Symptoms of overdose may include:

Severe stomach pain
Vomiting blood
Black, tarry stools
Difficulty breathing
Extreme drowsiness or confusion

What should you do if you suspect an Advil overdose? If any of these symptoms occur, seek immediate medical attention or contact a poison control center.

Understanding the potential side effects and proper usage of Advil is crucial for safe and effective pain management. While it’s a valuable over-the-counter medication for many, being aware of its risks and knowing when to seek alternatives or medical advice can help prevent complications and ensure optimal health outcomes.

Remember, every individual’s health situation is unique, and what works well for one person may not be suitable for another. Always consult with a healthcare professional if you have concerns about using Advil or experience any unusual symptoms while taking it. By staying informed and vigilant, you can make the most of Advil’s benefits while minimizing potential risks to your health.

Heartburn, Internal Bleeding & More

15 Ibuprofen (Advil) Side Effects: Heartburn, Internal Bleeding & More

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Medically reviewed by Alan Carter, Pharm. D. — By University of Illinois — Updated on March 8, 2019

Ibuprofen is a nonsteroidal anti-inflammatory pain reliever. It can cause minor digestive side effects. It may cause more severe side effects if you have certain health conditions or take it with other medications.

Advil is one of the name-brand versions of ibuprofen. You may know that it relieves minor aches, pains, and fever. However, you may not know the side effects of this common drug.

Learn what these effects are and when they’re most likely to occur so that you can use this drug safely.

Ibuprofen helps lower fever. It also helps relieve minor pain from:

headaches
toothaches
menstrual cramps
backaches
muscle aches

Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs temporarily reduce the amount of prostaglandins made by your body.

Your body releases prostaglandins when you have an injury. These hormone-like substances contribute to inflammation, which includes swelling, fever, and increased sensitivity to pain.

Ibuprofen is so widely used that it can be easy to forget this drug can cause side effects. Still, ibuprofen is a drug, and it comes with risks like any other drug.

The more common side effects of ibuprofen are:

stomach pain
heartburn
nausea
vomiting
gas
constipation
diarrhea

Not everyone has these side effects. When they do occur, the effects are usually mild. Many people can prevent these side effects by taking ibuprofen with milk or food.

Serious side effects can also occur. Most of these risks are uncommon and can usually be avoided by taking ibuprofen as recommended.

However, taking too much ibuprofen or taking it for too long can make these serious side effects more likely.

For most people, the risks of heart attack and stroke are rare. However, your risks increase if you use too much ibuprofen or use it for too long. Your risk is also higher if you:

have other risk factors for heart attack or stroke
have a clotting disorder
take other medications that affect how your blood clots

If you have any risk factors or take other drugs, talk to your doctor before using ibuprofen.

Prostaglandins help keep the pressure in your kidneys at the right level to filter the fluids in your body and maintain your blood pressure.

Ibuprofen changes your body’s production of prostaglandins. This change can lead to an imbalance in your body fluid pressure, which can decrease your kidney function and increase your blood pressure.

Symptoms of decreased kidney function include:

increased blood pressure
fluid buildup
dehydration
urinating less frequently
dizziness

Your risk is increased if you:

are an older adult
have kidney disease
take blood pressure medications

Prostaglandins also help maintain the constant repair of your stomach lining, which protects you from damage from stomach acid.

Because ibuprofen decreases how much prostaglandin you make, stomach damage such as bleeding and ulcers in the stomach and intestines is a possible side effect.

This side effect is fairly rare. However, the risk increases the longer you use ibuprofen. Other factors that increase your risk include:

a history of ulcers or bleeding in your stomach or intestines
older age
use of oral steroids or the blood thinners known as anticoagulants
smoking
alcohol use, specifically more than three alcoholic beverages per day

Did you know?
If you have severe stomach pain or you notice bloody or tarry stools, you may have symptoms of an ulcer. Contact your doctor right away and stop taking ibuprofen.

Some people have an allergic reaction to ibuprofen, but this is also rare.

If you’ve had allergic reactions to aspirin, don’t take ibuprofen. If you start to have trouble breathing or your face or throat starts to swell, contact your doctor right away and stop taking ibuprofen.

There’s a very rare risk of liver failure after taking ibuprofen. If you have liver disease, talk to your doctor before taking ibuprofen. Stop taking ibuprofen and contact your doctor right away if you start to have any of the following symptoms:

nausea
tiredness
lack of energy
itchiness
yellowing of your skin or the whites of your eyes
pain in the upper right area of your abdomen
flu-like symptoms

These may be signs of liver damage or liver failure.

Ibuprofen can be a safe and easy over-the-counter remedy (OTC) for minor aches and pains. However, if you don’t use it as recommended, ibuprofen can possibly be harmful.

It’s always smart to talk to your doctor before taking ibuprofen if you’re not sure if you should use it. If you experience bothersome side effects or believe you may have taken too much, contact your doctor right away.

Most of the serious side effects result from taking the drug when you shouldn’t, taking too much of it, or taking it for too long. You can reduce your risk of side effects by using the smallest possible dose for shortest possible time.

Last medically reviewed on March 7, 2019

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

Advil – ibuprofen sodium tablet, coated. (2018).
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5be198b8-396e-4b44-8819-e2e3b5d2ad0e
Ibuprofen – ibuprofen tablet, film coated. (2007).
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=953cee06-5c26-4f30-870a-46b9fbb66e79
Risser A, et al. (2009). NSAID prescribing precautions.
aafp.org/afp/2009/1215/p1371.html
Ibuprofen. (2016).
medlineplus.gov/druginfo/meds/a682159. html

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Current Version

Mar 8, 2019

Written By

University of Illinois-Chicago

Edited By

Heather Hobbs

Mar 7, 2019

Medically Reviewed By

Alan Carter, PharmD

Share this article

Medically reviewed by Alan Carter, Pharm.D. — By University of Illinois — Updated on March 8, 2019

Heartburn, Internal Bleeding & More

15 Ibuprofen (Advil) Side Effects: Heartburn, Internal Bleeding & More

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  - IBD
  - Migraine
  - Multiple Sclerosis (MS)
  - Rheumatoid Arthritis
  - Type 2 Diabetes
- Articles
  - Acid Reflux
  - ADHD
  - Allergies
  - Alzheimer’s & Dementia
  - Bipolar Disorder
  - Cancer
  - Crohn’s Disease
  - Chronic Pain
  - Cold & Flu
  - COPD
  - Depression
  - Fibromyalgia
  - Heart Disease
  - High Cholesterol
  - HIV
  - Hypertension
  - IPF
  - Osteoarthritis
  - Psoriasis
  - Skin Disorders and Care
  - STDs
Discover
- Wellness Topics
  - Nutrition
  - Fitness
  - Skin Care
  - Sexual Health
  - Women’s Health
  - Mental Well-Being
  - Sleep
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- Health Challenges
  - Mindful Eating
  - Sugar Savvy
  - Move Your Body
  - Gut Health
  - Mood Foods
  - Align Your Spine
- Find Care
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  - Dermatologists
  - Neurologists
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Medically reviewed by Alan Carter, Pharm. D. — By University of Illinois — Updated on March 8, 2019

Advil is one of the name-brand versions of ibuprofen. You may know that it relieves minor aches, pains, and fever. However, you may not know the side effects of this common drug.

Learn what these effects are and when they’re most likely to occur so that you can use this drug safely.

Ibuprofen helps lower fever. It also helps relieve minor pain from:

headaches
toothaches
menstrual cramps
backaches
muscle aches

Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs temporarily reduce the amount of prostaglandins made by your body.

Your body releases prostaglandins when you have an injury. These hormone-like substances contribute to inflammation, which includes swelling, fever, and increased sensitivity to pain.

Ibuprofen is so widely used that it can be easy to forget this drug can cause side effects. Still, ibuprofen is a drug, and it comes with risks like any other drug.

The more common side effects of ibuprofen are:

stomach pain
heartburn
nausea
vomiting
gas
constipation
diarrhea

Not everyone has these side effects. When they do occur, the effects are usually mild. Many people can prevent these side effects by taking ibuprofen with milk or food.

Serious side effects can also occur. Most of these risks are uncommon and can usually be avoided by taking ibuprofen as recommended.

However, taking too much ibuprofen or taking it for too long can make these serious side effects more likely.

For most people, the risks of heart attack and stroke are rare. However, your risks increase if you use too much ibuprofen or use it for too long. Your risk is also higher if you:

have other risk factors for heart attack or stroke
have a clotting disorder
take other medications that affect how your blood clots

If you have any risk factors or take other drugs, talk to your doctor before using ibuprofen.

Prostaglandins help keep the pressure in your kidneys at the right level to filter the fluids in your body and maintain your blood pressure.

Symptoms of decreased kidney function include:

increased blood pressure
fluid buildup
dehydration
urinating less frequently
dizziness

Your risk is increased if you:

are an older adult
have kidney disease
take blood pressure medications

Prostaglandins also help maintain the constant repair of your stomach lining, which protects you from damage from stomach acid.

Because ibuprofen decreases how much prostaglandin you make, stomach damage such as bleeding and ulcers in the stomach and intestines is a possible side effect.

This side effect is fairly rare. However, the risk increases the longer you use ibuprofen. Other factors that increase your risk include:

a history of ulcers or bleeding in your stomach or intestines
older age
use of oral steroids or the blood thinners known as anticoagulants
smoking
alcohol use, specifically more than three alcoholic beverages per day

Did you know?
If you have severe stomach pain or you notice bloody or tarry stools, you may have symptoms of an ulcer. Contact your doctor right away and stop taking ibuprofen.

Some people have an allergic reaction to ibuprofen, but this is also rare.

nausea
tiredness
lack of energy
itchiness
yellowing of your skin or the whites of your eyes
pain in the upper right area of your abdomen
flu-like symptoms

These may be signs of liver damage or liver failure.

Ibuprofen can be a safe and easy over-the-counter remedy (OTC) for minor aches and pains. However, if you don’t use it as recommended, ibuprofen can possibly be harmful.

Last medically reviewed on March 7, 2019

How we reviewed this article:

Advil – ibuprofen sodium tablet, coated. (2018).
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5be198b8-396e-4b44-8819-e2e3b5d2ad0e
Ibuprofen – ibuprofen tablet, film coated. (2007).
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=953cee06-5c26-4f30-870a-46b9fbb66e79
Risser A, et al. (2009). NSAID prescribing precautions.
aafp.org/afp/2009/1215/p1371.html
Ibuprofen. (2016).
medlineplus.gov/druginfo/meds/a682159. html

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Current Version

Mar 8, 2019

Written By

University of Illinois-Chicago

Edited By

Heather Hobbs

Mar 7, 2019

Medically Reviewed By

Alan Carter, PharmD

Share this article

Medically reviewed by Alan Carter, Pharm.D. — By University of Illinois — Updated on March 8, 2019

Vitamins AEVIT – CJSC FP MELIGEN

In our age, many people know firsthand what poor (irregular) nutrition, stress and frequent diets are. All these factors negatively affect our body, forcing it to work for wear and tear. As a result, there is inevitably a shortage of substances necessary for the body, including beauty vitamins – A and E. The lack of these vitamins entails a whole trail of diseases. AEvit has powerful immunostimulating and antioxidant effects, improves the condition of hair follicles and skin in general, and has a beneficial effect on vision. This drug does not contain any extra components, which virtually eliminates allergic reactions and contributes to the formation of a low price compared to similar drugs.

However, it should be understood that AEvit is not a panacea. AEvit is an auxiliary element in the body care system and cannot be a substitute for a healthy lifestyle.

Vitamins AEvit:
composition, properties and effects on the body

AEvit – transparent yellowish gelatin capsules filled with an oily solution.

The combination of vitamins A and E, the main components of the drug, has an effective effect on the vital activity of the body. The separate use of these vitamins gives a weak result, since vitamin E helps the body absorb vitamin A.
Vitamin E does not interfere with the process of vitamin A oxidation in the intestine. Vitamin A (retinol) contributes to the preservation of immunity, is necessary for the regeneration of the epithelium. That is why vitamin A is so popular in cosmetology in the treatment of acne, sunburn, and stimulation of collagen production.
Vitamin A takes an active part in the formation of visual pigments and ensures the adaptation of the eye in conditions of different levels of illumination (photoreception), contributing to the preservation and restoration of vision.

Another important area of activity of vitamin A is the development of the human skeletal system, as well as the correct embryonic development of the fetus.

Vitamin E is a powerful antioxidant that prevents the formation of harmful substances that adversely affect the body. Vitamin E is responsible for maintaining the normal functioning of the peripheral and central nervous systems, strengthens the walls of blood vessels and has an anti-sclerotic effect, stimulates the immune system, accelerates tissue regeneration, prevents premature aging of the body, and reduces fatigue.

Application of AEvit for the face

AEvit is a mixture of vitamins A and E in oil solution. Preservation of youthful skin directly depends on the sufficient content of vitamins A and E in the body, their combined use increases the elasticity and firmness of the skin, which is the main indicator of its youth.

Vitamin A has the following properties:

enhancing the antioxidant properties of vitamin E;
full restoration of all functions of the epithelium;
ensuring a full exchange in tissues at the cellular level;
moisture retention in epithelial cells;
strengthening of cellular immunity and strengthening of protective epidermal tissues;
stimulation of epithelial cell renewal processes;
inhibition of the development of viruses and bacteria;
improved capillary circulation.

Vitamin E has the following effect:

in combination with vitamin A prevents the latter from being oxidized;
gives an antioxidant effect;
restores tissue trophism and improves microcirculation;
regulates metabolic processes in tissues;
penetrates deep into the layers of the dermis, moisturizes and renews cells;
has a pronounced whitening effect, fights age spots;
stimulates regenerating processes and has a general rejuvenating effect.

The use of the drug has an intense rejuvenating effect on the skin:

Wrinkles are smoothed out, while deep wrinkles become less noticeable.
Accelerates cell regeneration and repair.
Improves skin elasticity and firmness.
Improves complexion.
Reduces the sensitivity of the skin.
Pores shrink.
There is a curative effect on acne.

Lack of vitamins A and E in the body is reflected, first of all, on the face: dryness, peeling, acne and pustules, inflammation, wrinkles.
In cosmetology, AEvit is used in the treatment of dermatological diseases, including psoriasis and seborrhea.

How to use

AEvit for the face is applied in its pure form directly to problem areas of the epidermis, including the delicate and sensitive area around the eyes. The drug is best applied in the evening, on cleansed facial skin, for about 45-60 minutes, after which the residue is removed with a paper towel. Such use of the drug is carried out in a course of 10 procedures. After all the procedures, you will notice a significant improvement in the condition of the skin: wrinkles will become less noticeable, the complexion will improve, and the skin itself will become more velvety and toned. This procedure is also good because it is suitable for all skin types.

AEvit can be added to night restorative products (creams, serums, gels, etc. ) For a single use, 2-3 drops of the drug are enough (you can get the composition of the capsule by piercing it with a needle).

AEvit is the best ingredient to add to home masks.
Recipes for face masks with AEvit

Anti-inflammatory mask for acne

Ingredients:

Boiled potatoes in their skins – 1 pc.
AEvit – 1 capsule.

Mash potatoes until smooth, add vitamins AEvit. Apply the warm mixture on a clean face and leave on for 20 minutes. Wash off the mask with cool water and apply a cream that matches the skin type and age category.

Nourishing mask for oily skin.

Composition:

Butter – 50 g.
Beeswax – 10g
Olive oil – 15 ml.
AEvit – 2 capsules.
Fresh strawberries – 3 pcs.

Melt butter and wax in a water bath, then add olive oil, strawberry puree (rub through a sieve to get rid of seeds) and AEvit. Spread a homogeneous mass on a clean face and hold for 15 minutes. Wash off the mask with water at room temperature and apply a moisturizing cream.

Purifying mask for oily skin.

Composition:

Lemon peel – from 2 pcs.
Boiling water – 1 cup.
Butter – 30 g.
Olive oil – 50 ml.
Egg yolk -1 pc.
Village honey – 1 tbsp. l.
Lemon juice – 10 drops.
AEvit – 2 capsules.
Camphor alcohol – 15 ml.
Mayonnaise – 15 ml.

Infuse lemon zest in boiling water for one hour. After that, strain, add the rest of the ingredients to the finished infusion and stir. Then turn on AEvit and stir again. Apply the mixture every evening, two hours before bedtime, on cleansed skin and keep for half an hour. Wash off with warm water. At the end of the procedure, apply a moisturizer.

Rejuvenating mask for dry skin.

Composition:

Cosmetic yellow clay – 20 g
Warm milk – 20 ml.
Fresh mint leaves chopped – 2 pcs.
AEvit – 1 capsule.
Egg yolk – 1 pc.

Dissolve the clay in milk until a homogeneous mass without lumps, add the remaining components, at the end of AEvit. Apply the mask on a pre-cleansed face and leave for 25 minutes. Wash off with room temperature water. After the procedure, moisturize the face with a cream appropriate for skin type and age.

Purifying mask for dry skin.

Composition:

AEvit – 4 capsules.
Egg yolk – 1 pc.
Finely ground sea salt – a pinch.
Mix AEvit with the rest of the ingredients and spread on a clean face. After 10 minutes, rinse with cool water and apply cream on the face.
Nourishing mask.

Composition:

AEvit – 1 capsule.
Fresh country honey – 1 tsp.
Olive oil (almond, linseed) – 1 tbsp. l.

Heat the oil in a water bath, mix with honey, add AEvit. Apply the mask for 15 minutes on the face, then rinse with warm water. At the end of the procedure, lubricate the face with a suitable cream.

Nourishing and rejuvenating masks with AEvit are recommended to be done 2 times, and cleansing masks once a week.

Aevit (LUMI)

The high quality sunflower oil used in our products helps to increase the absorption of vitamins. In the production of capsules, we use gelatin from the best Swiss manufacturer, due to which the exact dissolution time in the gastrointestinal tract is achieved.

The dosage of vitamins and products in our production is strictly controlled at all stages: from testing substances for activity to testing finished products for bioequivalence of maintaining control samples from the beginning of production to the present day.

Each batch is tested by an independent laboratory and has a conclusion from the laboratory.

Aevita capsules are available in 2 types: blisters and cardboard packs of 2 blisters.

Instructions for medical use of the drug AEVIT

Registration number : P N001776 / 01-2002 dated November 21, 2008

Trade name: Aevit

International Nonproprietary Name: Vitamin E + Retinol

Dosage form: capsules S

Composition per 1 capsule

Active substances:

Alpha-tocopherol acetate (vitamin E) 100 mg
Retinol palmitate (vitamin A) * 100000 IU

Excipients:

Soybean oil – up to 200 mg

Composition of the shell in terms of absolute dry matter:

Gelatin – 52.75 mg
Glycerol – 16.80 mg
Methyl parahydroxybenzoate – 0.45 mg*
* Composition – 1.7 million IU/g
Vitamin A palmitate – 990 mg
dl-alpha-tocopherol acetate – 10 mg

Description: Yellow to light brown spherical capsules filled with light yellow to dark yellow oily liquid without rancid odor.

Pharmacotherapeutic group: Multivitamin

Code ath : A11ja

Pharmacological action: Combined drug, the action of which is determined by the properties of fat -soluble vitamins A and E. Retinol (vitamin A) necessary to regulate the division and differentiation of the epithelium (enhances the division of epithelial cells of the skin of the skin of the skin of the skin of the skin of the skin of the skin , rejuvenates the cell population, inhibits keratization processes, takes part as a cofactor in various biochemical processes). Alpha-tocopherol (vitamin E) has antioxidant properties, inhibits the development of free radical reactions, prevents the formation of peroxides that damage cell membranes, which is important for development of the body, the normal function of the nervous and muscular systems. It is a cofactor of some enzyme systems. Normalizes capillary and tissue permeability, increases tissue resistance to hypoxia.

Pharmacokinetics: Retinol palmitate is well absorbed in the upper small intestine, penetrates into the lymphatic tract and enters the liver. After administration, the maximum plasma concentration is reached after 4 hours. Retinol is distributed unevenly in the body. Its largest amount is found in the liver and retina, it is found in the kidneys, adrenal glands and other endocrine glands. Retinol metabolic products are excreted by the kidneys. The half-life is 9.1 hours. Alpha-tocopherol acetate is absorbed in the gastrointestinal tract, most of it enters the lymph, quickly distributed in all tissues, excreted in the bile and in the form of metabolites in the urine.

Indications for use: Avitaminosis A, E. In complex therapy:

skin lesions and diseases accompanied by tissue trophism disorders (psoriasis, some forms of eczema, ichthyosis, seborrheic dermatitis).

Contraindications: Hypersensitivity to the components of the drug, hypervitaminosis A and / or E, children’s age (up to 18 years), pregnancy, lactation.

Method of administration and doses: Use only on the advice of a doctor. Inside, regardless of food intake, 1 caps / day. The course of treatment is 20-40 days at intervals of 3-6 months. It is possible to conduct repeated courses on the recommendation of a doctor.

Side effects: Allergic reactions (including skin rash), epigastric pain, dyspeptic disorders (nausea, vomiting, diarrhea).

Contraindications: Increased individual sensitivity to vitamins A and E. Children under 14 years of age.

Overdose: Symptoms of acute vitamin A overdose (develop 6 hours after administration): in adults – drowsiness, lethargy, diplopia, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, bleeding from the gums, dryness and ulceration of the oral mucosa, peeling of the lips, skin (especially of the palms), agitation, confusion.

Symptoms of chronic vitamin A intoxication: anorexia, bone pain, cracked and dry skin, lips, dryness of the oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss , yellow-orange spots on the soles, palms, in the region of the nasolabial triangle, hepatotoxic phenomena, increased intraocular pressure, oligomenorrhea, portal hypertension, hemolytic anemia, changes in bone radiographs, convulsions.

Symptoms of an overdose of vitamin E: when taken for a long period in doses of 400-800 IU / day – blurred vision, dizziness, headache, nausea, diarrhea, gastralgia, asthenia; when taking more than 800 IU / day for a long period – an increase in the risk of bleeding in patients with hypovitaminosis K, impaired metabolism of thyroid hormones, sexual dysfunction, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, retinal hemorrhage the membrane of the eye, hemorrhagic stroke, ascites. Treatment: withdrawal of the drug, symptomatic therapy.

Interaction with other drugs: Vitamin A increases the risk of hypercalcemia. Colstyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamin A and E (their dose may need to be increased). Oral contraceptives increase the concentration of vitamin A in plasma. Isotretinoin increases the risk of developing vitamin A intoxication.

The simultaneous use of tetracycline and vitamin A in high doses (50 thousand units and above) increases the risk of developing intracranial hypertension.

Vitamin E enhances the effect of glucocorticosteroid drugs, non-steroidal anti-inflammatory drugs, antioxidants, increases the effectiveness and reduces the toxicity of vitamins A, D, cardiac glycosides.

Administration of high doses of vitamin E can cause vitamin A deficiency in the body. Vitamin E increases the effectiveness of antiepileptic drugs in patients with epilepsy (in whom the content of lipid peroxidation products in the blood is increased).

Simultaneous use of vitamin E at a dose of more than 400 IU / day with anticoagulants (coumarin and indandione derivatives) increases the risk of hypoprothrombinemia and bleeding. High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

Special instructions: In order to avoid the development of hypervitaminosis A and E, the recommended doses should not be exceeded. When using the drug, one should take into account the high content of vitamin A (100 thousand IU) in it, and also that it is a therapeutic, not a prophylactic drug . A diet with a high content of selenium and sulfur-containing amino acids reduces the need for vitamin E.

Packing: Capsules. 10 capsules in a blister pack made of PVC film and polymer-coated paper or printed lacquered aluminum foil. 2, 3, 4 blister packs together with instructions for use are placed in a pack of chrome-ersatz cardboard or box cardboard. a sealed bag made of an opaque polyethylene film, or from a combined material “Bouflen”, or from a two-layer combined material. 50, 100, 200, 400, 600 blister packs, together with an equal number of instructions for use, are placed in a sealed polyethylene bag made of an opaque polyethylene film .It is allowed to apply instructions for use on the package. Polyethylene packages are placed in a cardboard box.

Storage conditions: Store in a dry, dark place at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life: 2 years. Do not use after the expiration date.

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