What are the common side effects of Effexor. How does Effexor affect weight gain. Can Effexor cause changes in appetite. What strategies help manage weight while taking Effexor. When should you consult a doctor about Effexor side effects.

Understanding Effexor: An Overview of the Antidepressant

Effexor, also known by its generic name venlafaxine, is a widely prescribed antidepressant belonging to the class of medications called serotonin-norepinephrine reuptake inhibitors (SNRIs). It is primarily used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. The medication works by affecting neurotransmitters in the brain, particularly serotonin and norepinephrine, to help regulate mood and alleviate symptoms associated with depression and anxiety.

How does Effexor work in the brain? Effexor functions by inhibiting the reuptake of serotonin and norepinephrine, two important neurotransmitters involved in mood regulation. By blocking their reabsorption, Effexor increases the availability of these chemicals in the brain, which can help improve mood, reduce anxiety, and alleviate other symptoms of depression.

Off-Label Uses of Effexor

While Effexor is primarily prescribed for depression and anxiety disorders, it has also been used off-label for various other conditions. These include:

• Post-traumatic stress disorder (PTSD)
• Bipolar disorder
• Attention-deficit hyperactivity disorder (ADHD)
• Nerve pain
• Migraines and tension headaches
• Hot flashes associated with menopause or chemotherapy

It’s important to note that these off-label uses are not FDA-approved, and the decision to prescribe Effexor for these conditions is made by healthcare providers based on individual patient needs and circumstances.

The Relationship Between Effexor and Weight Gain

One of the most common concerns among patients prescribed Effexor is its potential impact on body weight. While weight gain is listed as a possible side effect of Effexor, it’s essential to understand that not everyone experiences this issue. The relationship between Effexor and weight changes is complex and can vary from person to person.

Is weight gain a guaranteed side effect of Effexor? No, weight gain is not a guaranteed side effect of Effexor. While some individuals may experience weight changes while taking the medication, others may not notice any significant impact on their body weight. The effects can vary based on individual factors such as metabolism, lifestyle, and overall health.

Research Findings on Effexor and Weight Gain

Several studies have explored the relationship between Effexor and weight gain. Here’s a summary of key findings:

• Some studies have associated Effexor with significant weight gain, similar to other antidepressants like citalopram (Celexa), escitalopram (Lexapro), sertraline (Zoloft), and paroxetine (Paxil).
• Other research suggests that weight gain from venlafaxine (Effexor) may be small and potentially insignificant for many users.
• The impact of Effexor on weight appears to be less pronounced compared to some other antidepressants, particularly older medications like tricyclic antidepressants.

It’s important to note that the relationship between antidepressants and weight changes is still not fully understood and requires further research. Individual responses to the medication can vary significantly.

Common Side Effects of Effexor: Beyond Weight Changes

While weight gain often receives significant attention, it’s crucial to be aware of other potential side effects associated with Effexor. Understanding these effects can help patients better manage their expectations and communicate effectively with their healthcare providers.

What are the most common side effects of Effexor? The most frequently reported side effects of Effexor include:

• Dizziness
• Blurred vision
• Fatigue
• Dry mouth
• Insomnia or difficulty falling asleep
• Gastrointestinal issues (e.g., heartburn, constipation, gas, diarrhea)
• Vivid or unusual dreams
• Decreased sex drive or sexual dysfunction
• Sweating
• Prickly or tingling sensations

It’s important to remember that many of these side effects are typically mild and often subside within a few weeks as the body adjusts to the medication. Healthcare providers usually start patients on a low dose and gradually increase it to minimize the risk of significant side effects.

Managing Side Effects

How can patients manage common side effects of Effexor? Here are some strategies that may help:

1. Stay hydrated to combat dry mouth and constipation
2. Take the medication with food to reduce gastrointestinal discomfort
3. Establish a consistent sleep schedule to address insomnia
4. Engage in regular physical activity to boost energy levels and combat fatigue
5. Use relaxation techniques to manage dizziness and anxiety
6. Communicate openly with your healthcare provider about any persistent or bothersome side effects

The Complex Relationship Between Depression and Weight Changes

When discussing weight changes associated with Effexor, it’s crucial to consider the broader context of depression and its impact on weight. Depression itself can lead to significant changes in appetite and weight, which may complicate the assessment of medication-related effects.

How does depression affect weight? Depression can influence weight in several ways:

• Appetite changes: Some individuals with depression experience increased appetite and weight gain, while others may lose their appetite and lose weight.
• Energy levels: Depression often leads to fatigue and reduced physical activity, which can contribute to weight gain.
• Eating habits: Depressed individuals may be more likely to engage in emotional eating or make less healthy food choices.
• Metabolic changes: Some research suggests that depression may affect metabolism, potentially influencing weight regulation.

Given these factors, it’s essential to consider that weight changes observed while taking Effexor may not be solely attributable to the medication. The complex interplay between depression, lifestyle factors, and medication effects must be taken into account when evaluating weight-related concerns.

Strategies for Managing Weight While Taking Effexor

For individuals concerned about potential weight gain while taking Effexor, there are several strategies that can help maintain a healthy weight. It’s important to approach weight management holistically, focusing on overall health and well-being rather than solely on the number on the scale.

What are effective strategies for managing weight while taking Effexor? Consider the following approaches:

1. Maintain a balanced diet: Focus on consuming a variety of nutrient-dense foods, including fruits, vegetables, lean proteins, and whole grains. Be mindful of portion sizes and try to avoid excessive consumption of processed foods and sugary drinks.
2. Regular physical activity: Engage in a combination of cardiovascular exercise and strength training. Aim for at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity per week, along with muscle-strengthening activities at least twice a week.
3. Stay hydrated: Drink plenty of water throughout the day. Sometimes thirst can be mistaken for hunger, leading to unnecessary snacking.
4. Get adequate sleep: Aim for 7-9 hours of quality sleep per night. Poor sleep can disrupt hormones that regulate appetite and metabolism.
5. Manage stress: Practice stress-reduction techniques such as meditation, deep breathing exercises, or yoga. Chronic stress can contribute to weight gain and make it harder to maintain a healthy lifestyle.
6. Keep a food and mood journal: Track your eating habits and emotions to identify any patterns or triggers that may be contributing to weight changes.
7. Seek support: Consider working with a registered dietitian or joining a support group to help you develop and maintain healthy habits.

Remember that sustainable weight management is a long-term process. Focus on making gradual, lasting changes to your lifestyle rather than resorting to extreme diets or quick fixes.

The Importance of Proper Dosage and Administration of Effexor

Proper dosage and administration of Effexor play a crucial role in maximizing its benefits while minimizing potential side effects, including weight gain. Healthcare providers typically start patients on a low dose and gradually increase it to find the optimal balance between efficacy and tolerability.

What is the typical dosage regimen for Effexor? The standard dosing schedule for Effexor is as follows:

• Starting dose: Usually 37.5 mg per day
• Typical maintenance dose: 75 mg per day for treating depression, generalized anxiety, panic disorders, and social anxiety disorder
• Maximum dose: Up to 225 mg per day, depending on individual response and tolerability

It’s crucial to take Effexor exactly as prescribed by your healthcare provider. Do not adjust the dose or stop taking the medication without consulting your doctor, as abrupt discontinuation can lead to withdrawal symptoms.

Tips for Taking Effexor

How can patients ensure they’re taking Effexor correctly? Consider these tips:

1. Take Effexor at the same time each day to maintain consistent blood levels of the medication.
2. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.
3. Effexor can be taken with or without food, but taking it with food may help reduce nausea.
4. If you miss a dose, take it as soon as you remember. However, if it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule.
5. Avoid alcohol while taking Effexor, as it can increase the risk of side effects and may worsen depression symptoms.

Always communicate openly with your healthcare provider about any concerns or side effects you experience while taking Effexor. They can provide guidance on managing side effects or adjusting your treatment plan if necessary.

When to Consult Your Doctor About Effexor Side Effects

While many side effects of Effexor are mild and resolve on their own, there are situations where it’s important to seek medical advice. Being aware of these scenarios can help ensure your safety and optimize your treatment outcomes.

When should you contact your healthcare provider about Effexor side effects? Consider reaching out in the following situations:

• Severe or persistent side effects that significantly impact your quality of life
• Rapid or significant weight changes (gain or loss)
• Worsening of depression symptoms or emergence of suicidal thoughts
• Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, difficulty breathing)
• Unusual changes in mood or behavior
• Severe headaches or vision problems
• Persistent gastrointestinal issues
• Significant sexual side effects that don’t improve over time

It’s important to remember that your healthcare provider is your best resource for addressing concerns about Effexor or any other medication. They can help you weigh the benefits and risks of continuing treatment, adjust your dosage if necessary, or explore alternative treatment options if Effexor is not the right fit for you.

Monitoring Progress and Adjusting Treatment

How often should patients follow up with their healthcare provider while taking Effexor? The frequency of follow-up appointments may vary based on individual needs, but typically include:

1. Initial follow-up: Usually within 1-2 weeks of starting the medication
2. Regular check-ins: Every 4-6 weeks during the first few months of treatment
3. Ongoing monitoring: Every 3-6 months once your condition has stabilized

During these appointments, your healthcare provider will assess your response to the medication, monitor for side effects, and make any necessary adjustments to your treatment plan. Be prepared to discuss your symptoms, any side effects you’ve experienced, and any concerns you may have about your treatment.

Balancing the Benefits and Risks of Effexor Treatment

When considering Effexor or any antidepressant medication, it’s essential to weigh the potential benefits against the risks and side effects. While concerns about weight gain and other side effects are valid, it’s crucial to remember that the primary goal of treatment is to improve your mental health and overall well-being.

How can patients and healthcare providers work together to optimize Effexor treatment? Consider the following approaches:

• Open communication: Discuss your concerns, goals, and expectations with your healthcare provider openly and honestly.
• Regular monitoring: Attend follow-up appointments and participate actively in tracking your progress and any side effects.
• Lifestyle modifications: Implement healthy habits to support your mental health and manage potential side effects.
• Patience and persistence: Remember that it may take several weeks to experience the full benefits of Effexor, and side effects often improve with time.
• Explore additional support: Consider complementing your medication with psychotherapy, support groups, or other mental health resources.

Ultimately, the decision to continue or modify Effexor treatment should be made in collaboration with your healthcare provider, taking into account your individual needs, preferences, and overall health status.

Alternative Treatment Options

Are there alternatives to Effexor for treating depression and anxiety? Yes, there are several other treatment options available, including:

1. Other antidepressants: SSRIs, SNRIs, or medications from different classes
2. Psychotherapy: Cognitive-behavioral therapy (CBT), interpersonal therapy, or other evidence-based approaches
3. Combination therapy: Medication combined with psychotherapy
4. Lifestyle interventions: Exercise, nutrition, sleep hygiene, and stress management techniques
5. Alternative therapies: Mindfulness meditation, acupuncture, or herbal supplements (under medical supervision)

If you’re concerned about the side effects of Effexor or feel that it’s not the right fit for you, discuss these alternatives with your healthcare provider. They can help you explore options and develop a treatment plan that best addresses your individual needs and preferences.

Effexor Weight Gain: What You Should Know

When starting a new medication, it’s normal to feel anxious about how your body may react.

The prospect of experiencing side effects can be daunting, and depression and the medications used to treat it can affect your appetite and body weight in unwanted ways.

While side effects can range from annoying to scary, it’s also important to note that most of the time, the positive effects of the medication outweigh the negative. 

In this article, we’ll review a common side effect of antidepressants: weight gain, specifically in the context of Effexor.

We’ll review what Effexor is, the relationship between this medication and weight gain, and common side effects when taking it.

We’ll also go over precautions and when to see a doctor. 

What is Effexor?

Effexor (venlafaxine) is an antidepressant that is commonly prescribed to treat symptoms associated with depression and anxiety.

Effexor helps relieve symptoms that may occur with depression and anxiety, like sadness, hopelessness, guilt, and lack of interest in things that once brought you joy.

It can also be used to treat physical manifestations of anxiety, including nausea, jitters, or restlessness, amongst other things. 

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Effexor uses

Effexor is used to treat anxiety disorders, panic disorders, social phobia disorder, as well as major depressive disorder.

It can also be prescribed as a mood stabilizer, as well as used to treat post-traumatic stress disorder, bipolar disorder, and attention-deficit hyperactivity disorder. 

Other studies show that venlafaxine is effective in treating nerve pain, migraines, and tension headaches.

It has also been prescribed to treat hot flashes as a result of menopause or chemothrapy.

These are “off label” uses, meaning the FDA has not approved them for these diseases but prescribers can decide if it’s appropriate for individual patients.

How Effexor works

Antidepressants work by affecting the chemicals in the brain known as neurotransmitters.

These include the managing of available levels of serotonin, norepinephrine, and dopamine.

Effexor is part of a class of drugs known as SNRIs (serotonin-norepinephrine reuptake inhibitor), which regulate the amount of serotonin and norepinephrine molecules in the brain by blocking the reabsorption or reuptake of such chemicals.

This makes more of these chemicals available in the brain and results in mood regulation.

Effexor and Weight Gain

Many antidepressant and anxiety medications list weight gain as a potential side effect.

This is the case with Effexor as well, but not everyone experiences such side effects. 

What the research says

Studies show that newer antidepressant drugs may be associated with weight gain.

In one such study, venlafaxine was associated with significant weight gain, alongside citalopram (Celexa), escitalopram (Lexapro), sertraline (Zoloft), and paroxetine (Paxil).

Some studies and clinical studies show that patients treated with Effexor gain a significant amount of weight, while other studies show that weight gain from venlafaxine is small and potentially insignificant.  

While studies show that some antidepressants may cause weight gain, the effect of antidepressants on weight is still mixed and needs further examination. 

Common Side Effects of Effexor

Like many medications, there are a variety of side effects that may occur when taking Effexor.

These side effects are often mild, and a doctor will usually prescribe a low dose to start and build up slowly to a higher daily dose to avoid significant side effects.

Many of the side effects should go away within a few weeks. 

Common side effects include:

• Dizziness
• Blurred vision
• Fatigue
• Dry mouth
• Insomnia or difficulty falling asleep
• Gastrointestinal issues like heartburn, decreased appetite, constipation, gas, or diarrhea
• Vivid or unusual dreams
• Chills
• Decreased sex drive or difficulty achieving orgasm or ejaculation
• Sweating
• Prickly or tingling sensations

Depression and Weight Changes

There are a number of signs of depression.

A common one to look out for is appetite changes.

This may include a noticeable weight gain or loss.

This may occur in both clinically depressed, as well as “high functioning” depression. 

Those who are depressed may be less likely to make healthy eating choices, which may affect one’s weight more than a medication itself.

Depression also affects energy levels and your desire to do things that you once enjoyed.

This may affect one’s desire to exercise regularly, an important part of maintaining a healthy body weight. 

How to Take Effexor

Effexor is often taken daily with a starting dose of 37.5 mg per day, which is increased over time to 75 mg daily, a common dosage to treat depression, generalized anxiety, panic disorders, and social anxiety disorder.

Your doctor may adjust your dosage over time, but they do not usually recommend going over 225 mg per day. 

Effexor Precautions

Before starting Effexor, tell your doctor about all medications and supplements you take, as some can interact with the medication and cause serious side effects.

Especially in the beginning, it is best to avoid alcohol, as venlafaxine can make you drowsy. 

Before stopping Effexor, consult your doctor and they will help you wean off the medication.

Sudden and immediate stopping can cause withdrawal side effects like nausea, vomiting, headache, and irritability. It’s best to stop taking Effexor with the help of a psychiatrist. 

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When to See a Doctor

Speak with your doctor about what antidepressant medication is right for you.

If your side effects worsen or symptoms don’t begin to resolve in 6 weeks, you may want to try a different dose of medication. 

Contact a doctor immediately if you suspect signs of an overdose, which includes dizziness, flashes of hot and cold, dilated pupils, irregular heart rate, and seizures. 

With drugs that affect the serotonin levels in your brain, there is a risk of serotonin syndrome.

This is when your body has too much serotonin and requires immediate medical attention.

Symptoms include restlessness, insomnia, confusion, high blood pressure, sweating, diarrhea, headache, and goosebumps. 

If you experience serious side effects, including suicidal thoughts or worsening symptoms of depression, talk to someone immediately, such as calling a suicide crisis line like 988.

How K Health Can Help

Think you might need a prescription for Effexor (Venlafaxine)?

K Health has clinicians standing by 24/7 to evaluate your symptoms and determine if Effexor is right for you.

Get started with our free assessment, which will tell you in minutes if treatment could be a good fit. If yes, we’ll connect you right to a clinician who can prescribe medication and have it shipped right to your door.

Frequently Asked Questions

Will Effexor help me lose weight?

Side effects vary from patient to patient, but neither weight loss nor weight gain is guaranteed when taking antidepressants. Additionally, Effexor is not amongst the list of antidepressants that have been connected to weight loss, which include bupropion (Wellbutrin), fluoxetine (Prozac), and duloxetine (Cymbalta). The best way to lose weight is to make healthy lifestyle and eating choices, which can include managing caloric intake.

Has anyone gained weight on venlafaxine?

Weight gain is a possible side effect accompanied with taking venlafaxine, but side effects vary depending on the patient. The bottom line is that while some people may gain weight, there is no way to know whether you will experience such a side effect.

Is it hard to lose weight on venlafaxine?

While some patients in one study found it difficult to lose weight during and after taking venlafaxine, this is not a universal experience and will differ from patient to patient. If you’re having trouble losing weight on venlafaxine, seek the help of a registered dietitian.

Does Effexor affect appetite?

Decreased appetite is one of the possible and common side effects of Effexor. This may affect your weight, but will likely resolve as your body adjusts to the medication.

K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.

K Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions,
and medical associations. We avoid using tertiary references.

• Low-Dose Estradiol and the Serotonin-Norepinephrine Reuptake Inhibitor Venlafaxine for Vasomotor Symptoms. (2014.)
  https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1876676

• A drug combination that reduces weight gain associated with antidepressant therapy.
  https://otc.duke.edu/technologies/a-drug-combination-that-reduces-weight-gain-associated-with-antidepressant-therapy/

• Weight gain and associated factors in patients using newer antidepressant drugs. (2014.)
  https://pubmed.ncbi.nlm.nih.gov/25467076/

• Antidepressants cause minimal weight gain. (2014.)
  https://www.health.harvard.edu/blog/antidepressants-cause-minimal-weight-gain-201406067202

• Serotonin Syndrome. (2013.)
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865832/

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This document, provided by Lexicomp ^® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Effexor XR

Brand names: Canada

ACT Venlafaxine XR; APO-Venlafaxine XR; Auro-Venlafaxine XR; Effexor XR; M-Venlafaxine XR; PMS-Venlafaxine XR; PMSC-Venlafaxine XR; RIVA-Venlafaxine XR [DSC]; SANDOZ Venlafaxine XR; TARO-Venlafaxine XR; TEVA-Venlafaxine XR; Venlafaxine XR

Warning

• Drugs like this have increased the likelihood of suicidal thoughts or actions in children and young people. This risk may be higher in people who have tried or had suicidal thoughts in the past. All people taking this drug must be closely monitored. If you develop or worsen disorders such as depression, nervousness, anxiety, grouchiness, panic attacks, and changes in mood or behavior, contact your doctor immediately. Contact your doctor immediately if you have suicidal thoughts or suicide attempts.
• This drug is not approved for use in children. Consult your doctor.

What is this drug used for?

• Used to treat depression.
• Used to treat anxiety.
• Used to treat panic attacks.
• This drug may also be used for other indications. Consult your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you have high blood pressure.
• For narrow angle glaucoma.
• If you are taking weight loss medications.
• If you are taking any of the following drugs: linezolid or methylene blue.
• If you have taken medications for depression or Parkinson’s disease in the past 14 days. These include isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. An episode of very high blood pressure may occur.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

All forms:

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Avoid driving and other activities that require increased attention until you see how this drug affects you.
• Treatment with this drug should not be abruptly stopped without the consent of the doctor. This can increase the risk of side effects. Sometimes they can be severe and last for a long time. If necessary, this drug should be stopped gradually, as instructed by your doctor. Tell your doctor if you develop new symptoms or if existing ones worsen.
• High blood pressure has happened with this drug. Monitor your blood pressure as directed by your doctor.
• Avoid drinking alcohol while taking this drug.
• Check with your doctor before using marijuana, other forms of cannabis, or prescription or over-the-counter drugs that can slow you down.
• This drug may increase the risk of bleeding. Sometimes bleeding can be life-threatening. Consult your doctor.
• If you have bipolar disorder, manic episodes may occur while taking this drug. Call your doctor if you have signs of a manic episode.
• Some patients may be at increased risk of eye problems when using this drug. Your doctor may order an eye examination to see if you are at increased risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, swelling or redness around the eye.
• This drug may cause low sodium levels in the blood. In very severe cases, it can be deadly. Consult your doctor.
• The use of this drug was accompanied by an increase in cholesterol levels. If you have any questions, please consult your doctor.
• This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
• If you are 65 years of age or older, use this drug with caution. You may experience more side effects.
• In some cases, the drug may affect the growth rate in children and adolescents. They may need regular growth rate checks. Consult your doctor.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.
• Taking this drug in the middle or late pregnancy may cause some health problems for the mother or the newborn. Consult your doctor.

Sustained release capsules:

• Particles of this drug can be observed in the feces. This is normal and does not cause concern.

Extended release tablets:

• The shell of the tablet can sometimes be seen in the stool. This is normal and does not cause concern.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confused thinking, weakness, seizures, problems with balance.
• signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Seizures.
• Pain or pressure in the chest.
• Dyspnea.
• Cough.
• Bone pain.
• Against the background of taking such drugs, violations of sexual function were noted. These included decreased interest in sex, problems achieving orgasm, problems ejaculating, or problems getting or maintaining an erection. If you have any questions, please consult your doctor.
• A severe and sometimes deadly complication called serotonin syndrome can occur. This risk may be increased if certain other drugs are taken at the same time. Call your doctor right away if you experience agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythms, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting , a very severe headache.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Sleep disorders.
• Nervous tension and agitation.
• Anxiety.
• Weight loss.
• Feeling dizzy, drowsy, tired or weak.
• Shiver.
• Headache.
• Excessive sweating.
• Constipation, diarrhea, abdominal pain, nausea, vomiting, or decreased appetite.
• Gas formation.
• Dry mouth.
• Strange or unusual dreams.
• Yawn.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All editions:

• Take this drug with food.
• Take this drug at about the same time of day.
• Keep taking this drug as instructed by your doctor or other health care professional, even if you feel well.

Sustained release capsules:

• Swallow whole. Do not crush, chew, or dissolve the capsules or their contents.
• You can sprinkle the contents of the capsule into applesauce. Do not chew. Swallow immediately and drink cool water.

Extended release tablets:

• Swallow whole. Do not chew, break or crush.
• Take this drug with a full glass of water.

What if I miss a dose of a drug?

• Take the missed dose as soon as you can.
• If it’s time to take your next dose, don’t take the missed dose and then go back to your regular dosing schedule.
• Do not take 2 doses or an additional dose at the same time.

How do I store and/or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug recycling programs may be in place in your area.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• A separate instruction for patients is attached to the drug. Please read this information carefully. Reread it each time you refill your supply. If you have any questions about this drug, ask your doctor, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2022-09-01

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Date last updated

Monday, December 12, 2022

Venlafaxine: Pediatric Medication | Memorial Sloan Kettering Cancer Center

Pediatric Medicine

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This document provided by Lexicomp ^® contains all the information you need to know about the drug, including indications, directions for use, side effects, and when you should contact your healthcare provider.

Trade names: USA

Effexor XR

Brand names: Canada

ACT Venlafaxine XR; APO-Venlafaxine XR; Auro-Venlafaxine XR; Effexor XR; M-Venlafaxine XR; PMS-Venlafaxine XR; PMSC-Venlafaxine XR; RIVA-Venlafaxine XR [DSC]; SANDOZ Venlafaxine XR; TARO-Venlafaxine XR; TEVA-Venlafaxine XR; Venlafaxine XR

Warning

• Drugs like this have increased the likelihood of suicidal thoughts or actions in children and young people. This risk may be higher in people who have tried or had suicidal thoughts in the past. All people taking this drug must be closely monitored. If you develop or worsen disorders such as depression, nervousness, anxiety, grouchiness, panic attacks, and changes in mood or behavior, contact your doctor immediately. Contact your doctor immediately if you have suicidal thoughts or suicide attempts.
• This drug is not approved for use in children. Consult your doctor.

What is this drug used for?

• Used to treat depression.
• Used to treat anxiety.
• Used to treat panic attacks.
• This drug can be given to children for other indications. Consult your doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

• If your child has an allergy to this drug, any of its ingredients, other drugs, foods, or substances. Tell the doctor about the allergy and how it manifested itself in the child.
• If your child has high blood pressure.
• If your child has angle-closure glaucoma.
• If your child is taking weight loss medications.
• If your child has taken medications for depression or certain other illnesses in the last 14 days. These include isocarboxazid, phenelzine, and tranylcypromine. An episode of very high blood pressure may occur.
• If the child is receiving any of the following drugs: linezolid or methylene blue.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Talk to your doctor or pharmacist about all medicines your child is taking (prescription and over-the-counter, natural, and vitamins) and any health problems. You need to make sure it is safe to take this drug for your child’s illnesses and in combination with other drugs they are already taking. Do not start, stop taking, or change the dosage of any drug your child is taking without the doctor’s approval.

What do I need to know or do while my child is taking this drug?

All forms:

• Tell all health care providers who care for your child that your child is taking this drug. These are your child’s doctors, nurses, pharmacists and dentists.
• Check with your child’s doctor before using marijuana, other forms of cannabis, or prescription or over-the-counter drugs that may slow your child’s progress.
• Have your child avoid tasks or activities that require attention until you see how this drug works for your child. This includes cycling, playing sports, or using items such as scissors, lawn mowers, electric scooters, toy cars, or motorized vehicles.
• Treatment of a child with this drug should not be abruptly stopped without the consent of the doctor. This can increase your child’s risk of side effects. Sometimes they can be severe and last for a long time. If needed, this drug should be stopped gradually for your child as directed by the doctor. Tell the doctor if your child develops new symptoms or if existing ones get worse.
• High blood pressure has happened with this drug. Monitor your child’s blood pressure as directed by your doctor.
• Alcohol can interact with this drug. Make sure your child does not drink alcohol.
• This drug may increase the risk of bleeding. Sometimes bleeding can be life-threatening. Consult your doctor.
• If your child has bipolar disorder, manic episodes may occur while taking this drug. Call your doctor if your child has signs of a manic episode.
• Some patients may be at increased risk of eye problems when using this drug. Your child’s doctor may order an eye examination to see if your child is at increased risk for these eye problems. Call the doctor right away if your child has eye pain, vision changes, swelling, or redness around the eye.
• This drug may cause low sodium levels in the blood. In very severe cases, it can be deadly. Consult your doctor.
• The use of this drug was accompanied by an increase in cholesterol levels. If you have any questions, please consult your doctor.
• This drug may affect the results of some lab tests. Tell all health care workers and laboratory workers who provide your child’s health care that your child is taking this drug.
• In some cases, the drug may affect the growth rate in children and adolescents. They may need regular growth rate checks. Consult your doctor.

If your daughter is pregnant or breastfeeding:

• Consult physician if your daughter is pregnant, pregnant, or breastfeeding. The benefits and risks for your daughter and her baby will need to be discussed.
• Taking this drug in the middle or late pregnancy may cause some health problems for the mother or the newborn. Consult your doctor.

Sustained release capsules:

• You may see particles of this drug in your child’s stool. This is normal and does not cause concern.

Extended release tablets:

• The shell of the tablet can sometimes be seen in the baby’s stool. This is normal and does not cause concern.

What side effects should I report to my child’s doctor right away?

WARNING/CAUTION: Although rare, some people may have very serious and sometimes deadly side effects from this drug. Call your child’s doctor right away or get medical help if your child has any of the following signs or symptoms that could be associated with a very bad side effect:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confused thinking, weakness, seizures, problems with balance.
• signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Pain or pressure in the chest.
• Seizures.
• Dyspnea.
• Cough.
• Bone pain.
• A severe and sometimes deadly complication called serotonin syndrome can occur. This risk may be increased if the child is also taking certain other drugs. Call your child’s healthcare provider right away if your child has agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythm, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting, a very severe headache.

If your child is or may be sexually active:

• Against the background of taking such drugs, violations of sexual function were noted. These included decreased interest in sex, problems achieving orgasm, problems ejaculating, or problems getting or maintaining an erection. If you have any questions, please consult your doctor.

What are some other side effects of this drug?

Any drug can cause side effects. However, for many people, side effects are either minor or non-existent. Contact your child’s doctor or seek medical attention if any of these or other side effects bother your child or if they persist:

• Anxiety.
• Weight loss.
• Feeling dizzy, drowsy, tired or weak.
• Shiver.
• Headache.
• Nervous tension and agitation.
• Constipation, diarrhea, nausea, vomiting, or decreased appetite.
• Dry mouth.
• Gas formation.
• Sleep disorders.
• Excessive sweating.
• Strange or unusual dreams.
• Yawn.

This list of possible side effects is not exhaustive. If you have any questions about side effects, ask your child’s doctor. Talk to your child’s doctor about side effects.

You can report side effects to the National Health Board.

What is the best way to give this drug?

Give this drug to your child as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All editions:

• Give this drug with food.
• Give this drug at the same time of day.
• Keep giving this drug as directed by your child’s doctor or other health care provider, even if your child is feeling well.

Sustained release capsules:

• The child should swallow the drug whole. Do not let your child crush, chew, or dissolve the capsules or their contents.
• You can sprinkle the contents of the capsules into applesauce. Do not let your child chew the drug. Have your child swallow the medication immediately and drink it with cool water.

Extended release tablets:

• Ask your child to swallow whole. Ask your child not to chew, break, or crush the tablet.
• Give this drug with a full glass of water.

What if my child misses a dose of medication?

• Give the missed dose as soon as possible.
• If it is time for your child to take the next dose, do not take the missed dose and then go back to your child’s normal schedule.
• Do not give a double dose at the same time or additional doses.

How do I store and/or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug recycling programs may be in place in your area.

General information about medicines

• If your child’s symptoms or health problems do not improve, or worsen, contact your child’s doctor.
• Do not share your child’s medicine with others and do not give anyone else’s medicine to your child.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your child’s doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options.