How does Effexor affect body weight. What are the common side effects of Effexor. Can Effexor cause significant weight gain. How to manage weight changes while taking Effexor. What precautions should be taken when using Effexor. When to consult a doctor about Effexor side effects.

Understanding Effexor: Uses and Mechanism of Action

Effexor, also known by its generic name venlafaxine, is a widely prescribed antidepressant medication used to treat various mental health conditions. It belongs to a class of drugs called Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), which work by regulating the levels of certain neurotransmitters in the brain.

Primary Uses of Effexor

• Major depressive disorder
• Generalized anxiety disorder
• Panic disorder
• Social anxiety disorder

In addition to these FDA-approved uses, Effexor may be prescribed off-label for other conditions such as:

• Post-traumatic stress disorder (PTSD)
• Bipolar disorder
• Attention-deficit hyperactivity disorder (ADHD)
• Nerve pain
• Migraines and tension headaches
• Hot flashes associated with menopause or chemotherapy

How Does Effexor Work?

Effexor functions by inhibiting the reuptake of serotonin and norepinephrine in the brain. This mechanism increases the availability of these neurotransmitters, which play crucial roles in mood regulation and emotional well-being. By enhancing the levels of these chemicals, Effexor helps alleviate symptoms of depression and anxiety, such as sadness, hopelessness, guilt, and loss of interest in previously enjoyable activities.

The Relationship Between Effexor and Weight Changes

One of the concerns often raised by patients considering or taking Effexor is its potential impact on body weight. While weight gain is listed as a possible side effect of many antidepressants, including Effexor, the relationship between this medication and weight changes is not straightforward.

Research Findings on Effexor and Weight Gain

Studies investigating the effects of antidepressants on weight have yielded mixed results. Some research indicates that newer antidepressants, including venlafaxine, may be associated with weight gain. For instance, a study comparing various antidepressants found that venlafaxine, along with citalopram, escitalopram, sertraline, and paroxetine, was linked to significant weight gain in some patients.

However, other clinical studies have reported that weight gain from venlafaxine is relatively small and potentially insignificant. The variability in these findings suggests that individual responses to Effexor can differ considerably.

Factors Influencing Weight Changes

When considering weight changes in patients taking Effexor, it’s essential to account for several factors:

1. Individual metabolism and body composition
2. Dietary habits and physical activity levels
3. The underlying condition being treated (e.g., depression itself can affect appetite and weight)
4. Dosage and duration of treatment
5. Concurrent medications or health conditions

Common Side Effects of Effexor: Beyond Weight Changes

While weight gain is a concern for many patients, Effexor can cause various other side effects. It’s important to note that these effects are often mild and tend to diminish over time as the body adjusts to the medication.

Frequently Reported Side Effects

• Dizziness
• Blurred vision
• Fatigue
• Dry mouth
• Insomnia or sleep disturbances
• Gastrointestinal issues (e.g., heartburn, constipation, diarrhea)
• Changes in appetite
• Vivid or unusual dreams
• Chills
• Decreased libido or sexual dysfunction
• Excessive sweating
• Prickling or tingling sensations

Are these side effects permanent? Most side effects associated with Effexor are temporary and typically subside within a few weeks as the body adapts to the medication. However, if side effects persist or become severe, it’s crucial to consult with a healthcare provider.

Managing Weight Changes While Taking Effexor

For patients concerned about potential weight gain while taking Effexor, there are several strategies that can help maintain a healthy weight:

Dietary Considerations

Maintaining a balanced and nutritious diet is essential when taking any medication that may affect weight. Consider the following tips:

• Focus on whole, unprocessed foods
• Incorporate plenty of fruits, vegetables, and lean proteins
• Limit intake of sugary and high-fat foods
• Practice portion control
• Stay hydrated with water and unsweetened beverages

Physical Activity

Regular exercise can help offset potential weight gain and provide additional mental health benefits. Aim for at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity per week, along with strength training exercises.

Monitoring and Tracking

Keeping track of weight changes can help identify trends and prompt early intervention if needed. Consider:

• Regular weigh-ins (e.g., weekly or bi-weekly)
• Tracking food intake and physical activity in a journal or app
• Noting any changes in appetite or eating patterns

Open Communication with Healthcare Providers

Maintaining open dialogue with healthcare providers is crucial. They can offer personalized advice, adjust dosages if necessary, or explore alternative treatment options if weight changes become problematic.

Depression, Anxiety, and Their Impact on Weight

When considering the relationship between Effexor and weight changes, it’s important to recognize the role that depression and anxiety themselves can play in altering body weight.

Depression and Weight Fluctuations

Depression can significantly impact appetite and eating habits. Some individuals may experience weight gain due to increased appetite and emotional eating, while others may lose weight due to decreased appetite and loss of interest in food. These changes can occur independently of medication effects.

Anxiety and Weight

Anxiety disorders can also influence weight in various ways. Some people may experience weight loss due to increased physical restlessness or decreased appetite, while others might gain weight from stress-induced overeating or reduced physical activity.

How does treating depression and anxiety affect weight? Successful treatment of these conditions with medications like Effexor can sometimes lead to a normalization of eating patterns and activity levels, which may result in weight changes as the body returns to a more balanced state.

Precautions and Considerations When Taking Effexor

While Effexor can be an effective treatment for depression and anxiety, there are several precautions and considerations to keep in mind:

Medical History and Current Health Status

Before starting Effexor, it’s crucial to inform your healthcare provider about:

• Any history of heart problems, including high blood pressure
• Liver or kidney disease
• Seizure disorders
• Bipolar disorder
• Bleeding disorders
• Glaucoma
• History of substance abuse

Drug Interactions

Effexor can interact with various medications and substances, potentially leading to adverse effects. It’s important to disclose all current medications, including over-the-counter drugs, supplements, and herbal remedies, to your healthcare provider.

Pregnancy and Breastfeeding

Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the potential risks and benefits of Effexor with their healthcare provider. The medication may pose risks to the developing fetus or nursing infant.

Discontinuation Syndrome

Abruptly stopping Effexor can lead to discontinuation syndrome, characterized by symptoms such as dizziness, nausea, headache, and flu-like symptoms. Always consult with a healthcare provider before adjusting or stopping Effexor treatment.

When to Consult a Doctor About Effexor Side Effects

While many side effects of Effexor are mild and temporary, certain symptoms warrant immediate medical attention. It’s important to be vigilant and seek medical help if you experience any of the following:

Severe or Persistent Side Effects

• Severe headache or migraines
• Persistent gastrointestinal issues
• Significant changes in mood or behavior
• Severe allergic reactions (e.g., rash, itching, swelling)
• Seizures
• Unusual bleeding or bruising

Signs of Serotonin Syndrome

Serotonin syndrome is a rare but potentially life-threatening condition that can occur when there’s an excess of serotonin in the body. Symptoms include:

• Agitation or restlessness
• Confusion
• Rapid heart rate and high blood pressure
• Dilated pupils
• Loss of muscle coordination or twitching muscles
• Severe dizziness
• Excessive sweating
• Fever

When should you seek emergency medical care while taking Effexor? If you experience any signs of serotonin syndrome, severe allergic reactions, or have thoughts of self-harm or suicide, seek immediate medical attention.

Alternatives to Effexor: Exploring Other Treatment Options

While Effexor can be effective for many individuals, it’s not the only option for treating depression and anxiety. If you’re concerned about weight gain or other side effects, there are alternative treatments to consider:

Other Antidepressant Medications

Different classes of antidepressants may have varying effects on weight:

• Selective Serotonin Reuptake Inhibitors (SSRIs): Some SSRIs, like fluoxetine (Prozac), may be less likely to cause weight gain.
• Bupropion (Wellbutrin): Often associated with weight loss rather than gain.
• Mirtazapine (Remeron): May cause weight gain but can be effective for depression with significant appetite loss.

Non-Pharmacological Treatments

For some individuals, non-medication approaches can be effective either alone or in combination with pharmacotherapy:

• Psychotherapy: Various forms of talk therapy, such as cognitive-behavioral therapy (CBT), can be highly effective for depression and anxiety.
• Mindfulness and meditation: These practices can help manage symptoms and improve overall well-being.
• Exercise: Regular physical activity has been shown to have significant mood-boosting effects.
• Lifestyle changes: Improving sleep habits, nutrition, and stress management can positively impact mental health.

Complementary and Alternative Therapies

Some individuals find relief through alternative approaches, although it’s important to discuss these with a healthcare provider before trying them:

• Herbal supplements (e.g., St. John’s Wort, though this can interact with many medications)
• Acupuncture
• Light therapy (particularly for seasonal affective disorder)
• Omega-3 fatty acid supplementation

Can changing medications help with weight management? In some cases, switching to a different antidepressant or adjusting the treatment approach may help manage weight concerns. However, this decision should always be made in consultation with a healthcare provider, considering the overall effectiveness of the current treatment and the potential risks of changing medications.

The Importance of Personalized Treatment in Mental Health

When it comes to treating depression and anxiety, there’s no one-size-fits-all approach. The effectiveness of treatments, including medications like Effexor, can vary significantly from person to person.

Factors Influencing Treatment Response

Several factors can affect how an individual responds to antidepressant treatment:

• Genetic makeup
• Severity and type of depression or anxiety
• Co-existing medical conditions
• Lifestyle factors
• Previous treatment history

The Role of Patient Preferences

Patient preferences and values play a crucial role in treatment success. Some individuals may prioritize rapid symptom relief, while others may be more concerned about potential side effects. Open communication with healthcare providers about these preferences is essential for developing an effective treatment plan.

Monitoring and Adjusting Treatment

Regular follow-ups and ongoing communication with healthcare providers are vital for optimizing treatment outcomes. This allows for timely adjustments to medication dosages, switching to alternative treatments if necessary, or incorporating additional therapeutic approaches.

How often should you review your treatment plan with your healthcare provider? It’s generally recommended to have regular check-ins, especially in the early stages of treatment. These may be more frequent initially (e.g., every few weeks) and then spaced out as symptoms improve and stabilize.

Effexor Weight Gain: What You Should Know

When starting a new medication, it’s normal to feel anxious about how your body may react.

The prospect of experiencing side effects can be daunting, and depression and the medications used to treat it can affect your appetite and body weight in unwanted ways.

While side effects can range from annoying to scary, it’s also important to note that most of the time, the positive effects of the medication outweigh the negative. 

In this article, we’ll review a common side effect of antidepressants: weight gain, specifically in the context of Effexor.

We’ll review what Effexor is, the relationship between this medication and weight gain, and common side effects when taking it.

We’ll also go over precautions and when to see a doctor. 

What is Effexor?

Effexor (venlafaxine) is an antidepressant that is commonly prescribed to treat symptoms associated with depression and anxiety.

Effexor helps relieve symptoms that may occur with depression and anxiety, like sadness, hopelessness, guilt, and lack of interest in things that once brought you joy.

It can also be used to treat physical manifestations of anxiety, including nausea, jitters, or restlessness, amongst other things. 

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Effexor uses

Effexor is used to treat anxiety disorders, panic disorders, social phobia disorder, as well as major depressive disorder.

It can also be prescribed as a mood stabilizer, as well as used to treat post-traumatic stress disorder, bipolar disorder, and attention-deficit hyperactivity disorder. 

Other studies show that venlafaxine is effective in treating nerve pain, migraines, and tension headaches.

It has also been prescribed to treat hot flashes as a result of menopause or chemothrapy.

These are “off label” uses, meaning the FDA has not approved them for these diseases but prescribers can decide if it’s appropriate for individual patients.

How Effexor works

Antidepressants work by affecting the chemicals in the brain known as neurotransmitters.

These include the managing of available levels of serotonin, norepinephrine, and dopamine.

Effexor is part of a class of drugs known as SNRIs (serotonin-norepinephrine reuptake inhibitor), which regulate the amount of serotonin and norepinephrine molecules in the brain by blocking the reabsorption or reuptake of such chemicals.

This makes more of these chemicals available in the brain and results in mood regulation.

Effexor and Weight Gain

Many antidepressant and anxiety medications list weight gain as a potential side effect.

This is the case with Effexor as well, but not everyone experiences such side effects. 

What the research says

Studies show that newer antidepressant drugs may be associated with weight gain.

In one such study, venlafaxine was associated with significant weight gain, alongside citalopram (Celexa), escitalopram (Lexapro), sertraline (Zoloft), and paroxetine (Paxil).

Some studies and clinical studies show that patients treated with Effexor gain a significant amount of weight, while other studies show that weight gain from venlafaxine is small and potentially insignificant.  

While studies show that some antidepressants may cause weight gain, the effect of antidepressants on weight is still mixed and needs further examination. 

Common Side Effects of Effexor

Like many medications, there are a variety of side effects that may occur when taking Effexor.

These side effects are often mild, and a doctor will usually prescribe a low dose to start and build up slowly to a higher daily dose to avoid significant side effects.

Many of the side effects should go away within a few weeks. 

Common side effects include:

• Dizziness
• Blurred vision
• Fatigue
• Dry mouth
• Insomnia or difficulty falling asleep
• Gastrointestinal issues like heartburn, decreased appetite, constipation, gas, or diarrhea
• Vivid or unusual dreams
• Chills
• Decreased sex drive or difficulty achieving orgasm or ejaculation
• Sweating
• Prickly or tingling sensations

Depression and Weight Changes

There are a number of signs of depression.

A common one to look out for is appetite changes.

This may include a noticeable weight gain or loss.

This may occur in both clinically depressed, as well as “high functioning” depression. 

Those who are depressed may be less likely to make healthy eating choices, which may affect one’s weight more than a medication itself.

Depression also affects energy levels and your desire to do things that you once enjoyed.

This may affect one’s desire to exercise regularly, an important part of maintaining a healthy body weight. 

How to Take Effexor

Effexor is often taken daily with a starting dose of 37.5 mg per day, which is increased over time to 75 mg daily, a common dosage to treat depression, generalized anxiety, panic disorders, and social anxiety disorder.

Your doctor may adjust your dosage over time, but they do not usually recommend going over 225 mg per day. 

Effexor Precautions

Before starting Effexor, tell your doctor about all medications and supplements you take, as some can interact with the medication and cause serious side effects.

Especially in the beginning, it is best to avoid alcohol, as venlafaxine can make you drowsy. 

Before stopping Effexor, consult your doctor and they will help you wean off the medication.

Sudden and immediate stopping can cause withdrawal side effects like nausea, vomiting, headache, and irritability. It’s best to stop taking Effexor with the help of a psychiatrist. 

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When to See a Doctor

Speak with your doctor about what antidepressant medication is right for you.

If your side effects worsen or symptoms don’t begin to resolve in 6 weeks, you may want to try a different dose of medication. 

Contact a doctor immediately if you suspect signs of an overdose, which includes dizziness, flashes of hot and cold, dilated pupils, irregular heart rate, and seizures. 

With drugs that affect the serotonin levels in your brain, there is a risk of serotonin syndrome.

This is when your body has too much serotonin and requires immediate medical attention.

Symptoms include restlessness, insomnia, confusion, high blood pressure, sweating, diarrhea, headache, and goosebumps. 

If you experience serious side effects, including suicidal thoughts or worsening symptoms of depression, talk to someone immediately, such as calling a suicide crisis line like 988.

How K Health Can Help

Think you might need a prescription for Effexor (Venlafaxine)?

K Health has clinicians standing by 24/7 to evaluate your symptoms and determine if Effexor is right for you.

Get started with our free assessment, which will tell you in minutes if treatment could be a good fit. If yes, we’ll connect you right to a clinician who can prescribe medication and have it shipped right to your door.

Frequently Asked Questions

Will Effexor help me lose weight?

Side effects vary from patient to patient, but neither weight loss nor weight gain is guaranteed when taking antidepressants. Additionally, Effexor is not amongst the list of antidepressants that have been connected to weight loss, which include bupropion (Wellbutrin), fluoxetine (Prozac), and duloxetine (Cymbalta). The best way to lose weight is to make healthy lifestyle and eating choices, which can include managing caloric intake.

Has anyone gained weight on venlafaxine?

Weight gain is a possible side effect accompanied with taking venlafaxine, but side effects vary depending on the patient. The bottom line is that while some people may gain weight, there is no way to know whether you will experience such a side effect.

Is it hard to lose weight on venlafaxine?

While some patients in one study found it difficult to lose weight during and after taking venlafaxine, this is not a universal experience and will differ from patient to patient. If you’re having trouble losing weight on venlafaxine, seek the help of a registered dietitian.

Does Effexor affect appetite?

Decreased appetite is one of the possible and common side effects of Effexor. This may affect your weight, but will likely resolve as your body adjusts to the medication.

K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.

K Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions,
and medical associations. We avoid using tertiary references.

• Low-Dose Estradiol and the Serotonin-Norepinephrine Reuptake Inhibitor Venlafaxine for Vasomotor Symptoms. (2014.)
  https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1876676

• A drug combination that reduces weight gain associated with antidepressant therapy.
  https://otc.duke.edu/technologies/a-drug-combination-that-reduces-weight-gain-associated-with-antidepressant-therapy/

• Weight gain and associated factors in patients using newer antidepressant drugs. (2014.)
  https://pubmed.ncbi.nlm.nih.gov/25467076/

• Antidepressants cause minimal weight gain. (2014.)
  https://www.health.harvard.edu/blog/antidepressants-cause-minimal-weight-gain-201406067202

• Serotonin Syndrome. (2013.)
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865832/

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Adult Medication

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This document, provided by Lexicomp ^® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Effexor XR

Brand names: Canada

ACT Venlafaxine XR; APO-Venlafaxine XR; Auro-Venlafaxine XR; Effexor XR; M-Venlafaxine XR; PMS-Venlafaxine XR; PMSC-Venlafaxine XR; RIVA-Venlafaxine XR [DSC]; SANDOZ Venlafaxine XR; TARO-Venlafaxine XR; TEVA-Venlafaxine XR; Venlafaxine XR

Warning

• Drugs like this have increased the likelihood of suicidal thoughts or actions in children and young people. This risk may be higher in people who have tried or had suicidal thoughts in the past. All people taking this drug must be closely monitored. If you develop or worsen disorders such as depression, nervousness, anxiety, grouchiness, panic attacks, and changes in mood or behavior, contact your doctor immediately. Contact your doctor immediately if you have suicidal thoughts or suicide attempts.
• This drug is not approved for use in children. Consult your doctor.

What is this drug used for?

• Used to treat depression.
• Used to treat anxiety.
• Used to treat panic attacks.
• This drug may also be used for other indications. Consult your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you have high blood pressure.
• For narrow angle glaucoma.
• If you are taking weight loss medications.
• If you are taking any of the following drugs: linezolid or methylene blue.
• If you have taken medications for depression or Parkinson’s disease in the past 14 days. These include isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. An episode of very high blood pressure may occur.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

All forms:

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Avoid driving and other activities that require increased attention until you see how this drug affects you.
• Treatment with this drug should not be abruptly stopped without the consent of the doctor. This can increase the risk of side effects. Sometimes they can be severe and last for a long time. If necessary, this drug should be stopped gradually, as instructed by your doctor. Tell your doctor if you develop new symptoms or if existing ones worsen.
• High blood pressure has happened with this drug. Monitor your blood pressure as directed by your doctor.
• Avoid drinking alcohol while taking this drug.
• Check with your doctor before using marijuana, other forms of cannabis, or prescription or over-the-counter drugs that can slow you down.
• This drug may increase the risk of bleeding. Sometimes bleeding can be life-threatening. Consult your doctor.
• If you have bipolar disorder, manic episodes may occur while taking this drug. Call your doctor if you have signs of a manic episode.
• Some patients may be at increased risk of eye problems when using this drug. Your doctor may order an eye examination to see if you are at increased risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, swelling or redness around the eye.
• This drug may cause low sodium levels in the blood. In very severe cases, it can be deadly. Consult your doctor.
• The use of this drug was accompanied by an increase in cholesterol levels. If you have any questions, please consult your doctor.
• This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
• If you are 65 years of age or older, use this drug with caution. You may experience more side effects.
• In some cases, the drug may affect the growth rate in children and adolescents. They may need regular growth rate checks. Consult your doctor.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.
• Taking this drug in the middle or late pregnancy may cause some health problems for the mother or the newborn. Consult your doctor.

Sustained release capsules:

• Particles of this drug can be observed in the feces. This is normal and does not cause concern.

Extended release tablets:

• The shell of the tablet can sometimes be seen in the stool. This is normal and does not cause concern.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confused thinking, weakness, seizures, problems with balance.
• signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Seizures.
• Pain or pressure in the chest.
• Dyspnea.
• Cough.
• Bone pain.
• Against the background of taking such drugs, violations of sexual function were noted. These included decreased interest in sex, problems achieving orgasm, problems ejaculating, or problems getting or maintaining an erection. If you have any questions, please consult your doctor.
• A severe and sometimes deadly complication called serotonin syndrome can occur. This risk may be increased if certain other drugs are taken at the same time. Call your doctor right away if you experience agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythms, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting , a very severe headache.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Sleep disorders.
• Nervous tension and agitation.
• Anxiety.
• Weight loss.
• Feeling dizzy, drowsy, tired or weak.
• Shiver.
• Headache.
• Excessive sweating.
• Constipation, diarrhea, abdominal pain, nausea, vomiting, or decreased appetite.
• Gas formation.
• Dry mouth.
• Strange or unusual dreams.
• Yawn.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All editions:

• Take this drug with food.
• Take this drug at about the same time of day.
• Keep taking this drug as instructed by your doctor or other health care professional, even if you feel well.

Sustained release capsules:

• Swallow whole. Do not crush, chew, or dissolve the capsules or their contents.
• You can sprinkle the contents of the capsule into applesauce. Do not chew. Swallow immediately and drink cool water.

Extended release tablets:

• Swallow whole. Do not chew, break or crush.
• Take this drug with a full glass of water.

What if I miss a dose of a drug?

• Take the missed dose as soon as you can.
• If it’s time to take your next dose, don’t take the missed dose and then go back to your regular dosing schedule.
• Do not take 2 doses or an additional dose at the same time.

How do I store and/or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug recycling programs may be in place in your area.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• A separate instruction for patients is attached to the drug. Please read this information carefully. Reread it each time you refill your supply. If you have any questions about this drug, ask your doctor, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2022-09-01

Copyright

© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

Venlafaxine: Pediatric Medication | Memorial Sloan Kettering Cancer Center

Pediatric Medicine

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This document provided by Lexicomp ^® contains all the information you need to know about the drug, including indications, directions for use, side effects, and when you should contact your healthcare provider.

Trade names: USA

Effexor XR

Brand names: Canada

ACT Venlafaxine XR; APO-Venlafaxine XR; Auro-Venlafaxine XR; Effexor XR; M-Venlafaxine XR; PMS-Venlafaxine XR; PMSC-Venlafaxine XR; RIVA-Venlafaxine XR [DSC]; SANDOZ Venlafaxine XR; TARO-Venlafaxine XR; TEVA-Venlafaxine XR; Venlafaxine XR

Warning

• Drugs like this have increased the likelihood of suicidal thoughts or actions in children and young people. This risk may be higher in people who have tried or had suicidal thoughts in the past. All people taking this drug must be closely monitored. If you develop or worsen disorders such as depression, nervousness, anxiety, grouchiness, panic attacks, and changes in mood or behavior, contact your doctor immediately. Contact your doctor immediately if you have suicidal thoughts or suicide attempts.
• This drug is not approved for use in children. Consult your doctor.

What is this drug used for?

• Used to treat depression.
• Used to treat anxiety.
• Used to treat panic attacks.
• This drug can be given to children for other indications. Consult your doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

• If your child has an allergy to this drug, any of its ingredients, other drugs, foods, or substances. Tell the doctor about the allergy and how it manifested itself in the child.
• If your child has high blood pressure.
• If your child has angle-closure glaucoma.
• If your child is taking weight loss medications.
• If your child has taken medications for depression or certain other illnesses in the last 14 days. These include isocarboxazid, phenelzine, and tranylcypromine. An episode of very high blood pressure may occur.
• If the child is receiving any of the following drugs: linezolid or methylene blue.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Talk to your doctor or pharmacist about all medicines your child is taking (prescription and over-the-counter, natural, and vitamins) and any health problems. You need to make sure it is safe to take this drug for your child’s illnesses and in combination with other drugs they are already taking. Do not start, stop taking, or change the dosage of any drug your child is taking without the doctor’s approval.

What do I need to know or do while my child is taking this drug?

All forms:

• Tell all health care providers who care for your child that your child is taking this drug. These are your child’s doctors, nurses, pharmacists and dentists.
• Check with your child’s doctor before using marijuana, other forms of cannabis, or prescription or over-the-counter drugs that may slow your child’s progress.
• Have your child avoid tasks or activities that require attention until you see how this drug works for your child. This includes cycling, playing sports, or using items such as scissors, lawn mowers, electric scooters, toy cars, or motorized vehicles.
• Treatment of a child with this drug should not be abruptly stopped without the consent of the doctor. This can increase your child’s risk of side effects. Sometimes they can be severe and last for a long time. If needed, this drug should be stopped gradually for your child as directed by the doctor. Tell the doctor if your child develops new symptoms or if existing ones get worse.
• High blood pressure has happened with this drug. Monitor your child’s blood pressure as directed by your doctor.
• Alcohol can interact with this drug. Make sure your child does not drink alcohol.
• This drug may increase the risk of bleeding. Sometimes bleeding can be life-threatening. Consult your doctor.
• If your child has bipolar disorder, manic episodes may occur while taking this drug. Call your doctor if your child has signs of a manic episode.
• Some patients may be at increased risk of eye problems when using this drug. Your child’s doctor may order an eye examination to see if your child is at increased risk for these eye problems. Call the doctor right away if your child has eye pain, vision changes, swelling, or redness around the eye.
• This drug may cause low sodium levels in the blood. In very severe cases, it can be deadly. Consult your doctor.
• The use of this drug was accompanied by an increase in cholesterol levels. If you have any questions, please consult your doctor.
• This drug may affect the results of some lab tests. Tell all health care workers and laboratory workers who provide your child’s health care that your child is taking this drug.
• In some cases, the drug may affect the growth rate in children and adolescents. They may need regular growth rate checks. Consult your doctor.

If your daughter is pregnant or breastfeeding:

• Consult physician if your daughter is pregnant, pregnant, or breastfeeding. The benefits and risks for your daughter and her baby will need to be discussed.
• Taking this drug in the middle or late pregnancy may cause some health problems for the mother or the newborn. Consult your doctor.

Sustained release capsules:

• You may see particles of this drug in your child’s stool. This is normal and does not cause concern.

Extended release tablets:

• The shell of the tablet can sometimes be seen in the baby’s stool. This is normal and does not cause concern.

What side effects should I report to my child’s doctor right away?

WARNING/CAUTION: Although rare, some people may have very serious and sometimes deadly side effects from this drug. Call your child’s doctor right away or get medical help if your child has any of the following signs or symptoms that could be associated with a very bad side effect:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confused thinking, weakness, seizures, problems with balance.
• signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Pain or pressure in the chest.
• Seizures.
• Dyspnea.
• Cough.
• Bone pain.
• A severe and sometimes deadly complication called serotonin syndrome can occur. This risk may be increased if the child is also taking certain other drugs. Call your child’s healthcare provider right away if your child has agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythm, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting, a very severe headache.

If your child is or may be sexually active:

• Against the background of taking such drugs, violations of sexual function were noted. These included decreased interest in sex, problems achieving orgasm, problems ejaculating, or problems getting or maintaining an erection. If you have any questions, please consult your doctor.

What are some other side effects of this drug?

Any drug can cause side effects. However, for many people, side effects are either minor or non-existent. Contact your child’s doctor or seek medical attention if any of these or other side effects bother your child or if they persist:

• Anxiety.
• Weight loss.
• Feeling dizzy, drowsy, tired or weak.
• Shiver.
• Headache.
• Nervous tension and agitation.
• Constipation, diarrhea, nausea, vomiting, or decreased appetite.
• Dry mouth.
• Gas formation.
• Sleep disorders.
• Excessive sweating.
• Strange or unusual dreams.
• Yawn.

This list of possible side effects is not exhaustive. If you have any questions about side effects, ask your child’s doctor. Talk to your child’s doctor about side effects.

You can report side effects to the National Health Board.

What is the best way to give this drug?

Give this drug to your child as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All editions:

• Give this drug with food.
• Give this drug at the same time of day.
• Keep giving this drug as directed by your child’s doctor or other health care provider, even if your child is feeling well.

Sustained release capsules:

• The child should swallow the drug whole. Do not let your child crush, chew, or dissolve the capsules or their contents.
• You can sprinkle the contents of the capsules into applesauce. Do not let your child chew the drug. Have your child swallow the medication immediately and drink it with cool water.

Extended release tablets:

• Ask your child to swallow whole. Ask your child not to chew, break, or crush the tablet.
• Give this drug with a full glass of water.

What if my child misses a dose of medication?

• Give the missed dose as soon as possible.
• If it is time for your child to take the next dose, do not take the missed dose and then go back to your child’s normal schedule.
• Do not give a double dose at the same time or additional doses.

How do I store and/or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug recycling programs may be in place in your area.

General information about medicines

• If your child’s symptoms or health problems do not improve, or worsen, contact your child’s doctor.
• Do not share your child’s medicine with others and do not give anyone else’s medicine to your child.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your child’s doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options.