Endocet 5 325. Endocet 5/325: Understanding the Combination of Acetaminophen and Oxycodone for Pain Management

13.09.202319.07.2023 by alexxlab

What is Endocet 5/325. How does it compare to Percocet. What are the main uses, side effects, and precautions for this pain medication. Is Endocet safe during pregnancy and breastfeeding. How to use Endocet responsibly and avoid potential risks.

Содержание

What is Endocet 5/325 and How Does It Work?

Endocet 5/325 is a prescription pain medication that combines two active ingredients: acetaminophen (325 mg) and oxycodone (5 mg). This potent combination is designed to provide relief for moderate to severe pain that has not responded adequately to other treatments.

Acetaminophen, also known as paracetamol, is a non-steroidal anti-inflammatory drug (NSAID) that works by reducing the production of prostaglandins in the body. These chemicals are responsible for pain and inflammation. Oxycodone, on the other hand, is an opioid that binds to specific receptors in the brain, altering the perception of pain and providing a strong analgesic effect.

The synergistic action of these two components makes Endocet 5/325 an effective option for managing pain associated with injuries, surgeries, and various medical conditions.

Endocet vs. Percocet: Similarities and Differences

Endocet and Percocet are often compared due to their similar composition and uses. Here are the key points to understand about these medications:

Active Ingredients: Both Endocet and Percocet contain the same active ingredients – acetaminophen and oxycodone.
Dosage Strengths: They are available in identical strengths, including 325 mg-2.5 mg, 325 mg-5 mg, 325 mg-7.5 mg, and 325 mg-10 mg of acetaminophen and oxycodone, respectively.
Manufacturer: Both medications are manufactured by Endo Pharmaceuticals.
Side Effects: The common side effects are the same for both drugs, including constipation, drowsiness, dizziness, nausea, and headache.
Prescription and Use: Both are prescription medications used for moderate to severe pain relief.
Generic Availability: Generic versions of both Endocet and Percocet (acetaminophen/oxycodone) are available.

Given these similarities, the choice between Endocet and Percocet often comes down to individual patient factors and physician preference.

Dosage and Administration of Endocet 5/325

The typical dosage for Endocet 5/325 is one tablet every 6 hours as needed for pain. However, it’s crucial to understand that dosage can vary based on individual factors such as pain severity, medical history, and response to treatment.

Important Dosage Considerations:

Maximum Daily Dose: The maximum recommended daily dose of acetaminophen is 4000 mg. Exceeding this limit can lead to severe liver damage.
Dosage Adjustments: Your healthcare provider may adjust the dosage based on your pain levels and how you respond to the medication.
Duration of Use: Endocet is typically prescribed for short-term use due to the risk of dependence associated with opioid medications.

Always follow your doctor’s instructions precisely when taking Endocet. Never increase your dose without consulting your healthcare provider first.

Common Side Effects and Precautions

Like all medications, Endocet 5/325 can cause side effects. It’s important to be aware of these potential adverse reactions:

Constipation
Drowsiness
Dizziness
Headache
Nausea
Vomiting
Pruritus (itching)
Lethargy
Fatigue

While these side effects are common, they should be reported to your healthcare provider if they persist or become severe. In rare cases, more serious side effects may occur, including respiratory depression, severe allergic reactions, or liver damage.

Precautions When Using Endocet:

Avoid alcohol consumption while taking Endocet, as it can increase the risk of liver damage and enhance the sedative effects of the medication.
Do not drive or operate heavy machinery until you know how the medication affects you, as it can cause drowsiness and impair cognitive function.
Inform your doctor about all other medications you’re taking, including over-the-counter drugs and supplements, to avoid potential drug interactions.
Be aware of the signs of opioid dependence and addiction, and discuss any concerns with your healthcare provider.

Drug Interactions and Contraindications

Endocet 5/325 can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. Some notable interactions include:

Alcohol
SSRI/SNRI antidepressants
Triptans
CNS depressants (including other opioids, antihistamines, antipsychotics, and hypnotics)
Mixed agonist/antagonist analgesics
MAO inhibitors
Tricyclic antidepressants
CYP3A4 and CYP2D6 inhibitors and inducers
Muscle relaxants
Diuretics
Oral contraceptives

This list is not exhaustive, and it’s crucial to provide your healthcare provider with a complete list of all medications you’re taking before starting Endocet.

Contraindications:

Endocet 5/325 is contraindicated in certain situations, including:

Known hypersensitivity to acetaminophen or oxycodone
Severe respiratory depression
Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment
Known or suspected gastrointestinal obstruction, including paralytic ileus

Endocet and Pregnancy: Safety Considerations

The use of Endocet during pregnancy requires careful consideration and should only be done under the guidance of a healthcare professional. Endocet is classified as a Pregnancy Category C medication, which means that while adverse effects have been reported in animal studies, there is insufficient research on its effects in humans.

Pregnant women should be aware of the potential risks associated with opioid use during pregnancy, including:

Neonatal opioid withdrawal syndrome
Potential for birth defects
Increased risk of preterm labor
Possible developmental issues for the fetus

If you are pregnant or planning to become pregnant, it’s crucial to discuss the risks and benefits of Endocet use with your healthcare provider. They can help determine if the potential benefits outweigh the risks in your specific situation.

Breastfeeding Considerations:

Endocet is not recommended for use while breastfeeding. Both acetaminophen and oxycodone can pass into breast milk, potentially affecting the nursing infant. If you are breastfeeding or plan to breastfeed, discuss alternative pain management options with your healthcare provider.

Managing Pain Responsibly: Alternatives and Long-Term Considerations

While Endocet 5/325 can be an effective pain management tool, it’s important to consider alternative options and long-term strategies for pain control. This is particularly relevant given the potential risks associated with opioid use, including dependence and addiction.

Alternative Pain Management Strategies:

Non-opioid medications (e.g., NSAIDs, topical analgesics)
Physical therapy
Acupuncture
Cognitive-behavioral therapy
Relaxation techniques (e.g., meditation, deep breathing exercises)
Heat or cold therapy
Exercise and stretching programs

Your healthcare provider can help you develop a comprehensive pain management plan that may incorporate a combination of these strategies along with appropriate medication use.

Long-Term Considerations:

If you find yourself requiring Endocet or similar opioid medications for an extended period, it’s crucial to have ongoing discussions with your healthcare provider about:

The effectiveness of your current pain management strategy
Potential risks of long-term opioid use
Strategies to minimize the risk of dependence and addiction
Regular assessments of your pain levels and functional goals
Gradual tapering of opioid medications when appropriate

Remember, the goal of pain management is not just to reduce pain, but to improve overall function and quality of life. Working closely with your healthcare team can help ensure that you’re using Endocet safely and effectively as part of a broader pain management strategy.

Endocet vs Percocet: Main Differences and Similarities

Endocet and Percocet are two brand names for the combination of acetaminophen and oxycodone. This combination medication is often prescribed for moderate to severe pain that is not relieved with other therapies.

Acetaminophen is a nonsteroidal anti-inflammatory drug (NSAID) that treats pain and inflammation by decreasing the production of prostaglandins. Oxycodone is an opioid that binds to mu receptors in the brain. This combination produces a strong analgesic effects to relieve pain from injury, surgery, and other conditions.

Endocet

Endocet comes in strengths of 325 mg-2.5 mg, 325 mg-5 mg, 325 mg-7.5 mg, and 325 mg-10 mg of acetaminophen and oxycodone. The usual dose of Endocet is given every 6 hours as needed for pain. Common side effects of Endocet include constipation, nausea, and somnolence.

Percocet

Percocet is available in strengths of 325 mg-2.5 mg, 325 mg-5 mg, 325 mg-7.5 mg, and 325 mg-10 mg of acetaminophen and oxycodone. Percocet can be taken every 6 hours as needed for pain depending on a doctor’s prescription. Common side effects of Percocet include constipation, nausea, and somnolence.

Endocet vs Percocet Side by Side Comparison

Endocet and Percocet are identical medications used for pain. Their features can be found in the table below.

Endocet	Percocet
Prescribed For
Moderate to severe pain	Moderate to severe pain
Drug Classification
Opioid	Opioid
Manufacturer
Endo Pharmaceuticals	Endo Pharmaceuticals
Common Side Effects
Constipation Drowsiness Dizziness Headache Nausea Vomiting Pruritus Lethargy Fatigue	Constipation Drowsiness Dizziness Headache Nausea Vomiting Pruritus Lethargy Fatigue
Is there a generic?
Yes, acetaminophen/oxycodone	Yes, acetaminophen/oxycodone
Is it covered by insurance?
Varies according to your provider	Varies according to your provider
Dosage Forms
Oral tablet	Oral tablet
Average Cash Price
$152 for a supply of 100, 2. 5 mg capsules	$152 for a supply of 100, 2.5 mg capsules
SingleCare Discount Price
Endocet Price	Percocet Price
Drug Interactions
Alcohol SSRI/SNRI antidepressants Triptans CNS depressants (opioids, antihistamines, antipsychotics, antianxiety agents, hypnotics, antiemetics, phenothiazines, tranquilizers) Mixed agonist/antagonist analgesics (butorphanol, nalbuphine, pentazocine, buprenorphine) Anticholinergics MAO inhibitors Tricyclic antidepressants CYP3A4 and CYP2D6 inhibitors (macrolide antibiotics, azole-antifungal agents, protease inhibitors) CYP3A4 inducers (rifampin, carbamazepine, phenytoin) Muscle relaxants Diuretics Oral contraceptives Beta blockers (propranolol) Lamotrigine Probenecid	Alcohol SSRI/SNRI antidepressants Triptans CNS depressants (opioids, antihistamines, antipsychotics, antianxiety agents, hypnotics, antiemetics, phenothiazines, tranquilizers) Mixed agonist/antagonist analgesics (butorphanol, nalbuphine, pentazocine, buprenorphine) Anticholinergics MAO inhibitors Tricyclic antidepressants CYP3A4 and CYP2D6 inhibitors (macrolide antibiotics, azole-antifungal agents, protease inhibitors) CYP3A4 inducers (rifampin, carbamazepine, phenytoin) Muscle relaxants Diuretics Oral contraceptives Beta blockers (propranolol) Lamotrigine Probenecid
Can I use while planning pregnancy, pregnant, or breastfeeding?
Endocet is in Pregnancy Category C. While adverse effects have been reported in animals, not enough research has been performed in humans. Consult a doctor regarding steps to take while planning pregnancy. Endocet is not recommended while breastfeeding	Percocet is in Pregnancy Category C. While adverse effects have been reported in animals, not enough research has been performed in humans. Consult a doctor regarding steps to take while planning pregnancy. Percocet is not recommended while breastfeeding.

Summary

Endocet and Percocet contain the same active ingredients, acetaminophen and oxycodone. As a potent opioid combination, Endocet and Percocet can help relieve moderate to severe pain.

Both Endocet and Percocet come in similar dosage forms. They can both be taken multiple times throughout the day as needed for pain. However, the maximum recommended daily dose of acetaminophen is 4000 mg. This is because acetaminophen can cause liver damage at high doses.

Acetaminophen and oxycodone can cause side effects such as constipation and nausea. As a Schedule II drug, this combination also has a high risk for abuse and dependence. Those who abuse acetaminophen and oxycodone report feelings of euphoria which can lead to addiction.

It is important to discuss these medications with a doctor. This information should be reviewed with a doctor to determine the best treatment option for you.

Endocet – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

This combination product contains two medications: oxycodone and acetaminophen. Acetaminophen belongs to the group of medications called analgesics (pain relievers) and antipyretics (fever reducers). Oxycodone belongs to the group of medications called narcotic analgesics. Oxycodone – acetaminophen is used to relieve moderate to moderately severe pain, including conditions associated with fever. This medication should only be used when other non-narcotic pain medications are not effective or tolerated.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Endocet is no longer being manufactured for sale in Canada. For brands that may still be available, search under oxycodone – acetaminophen. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

How should I use this medication?

The dosage varies according to each individual and can be affected by the severity of the pain as well as each person’s response to the medication.

The usual recommended adult dose of oxycodone – acetaminophen (each tablet contains 5 mg oxycodone and 325 mg acetaminophen) is one tablet every 6 hours as needed for pain. This medication should be used at the lowest dose that provides pain relief for a maximum of 7 days.

Swallow the tablets whole with fluid. Do not cut, break, crush, chew, or dissolve the tablets. Doing so can result in dangerous adverse events, including death.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

This medication may be habit-forming if taken for long periods of time. Do not stop taking this medication without talking with your doctor. If this medication is stopped suddenly, you may experience withdrawal symptoms such as anxiety, sweating, trouble sleeping, shakiness, nausea, tremors, diarrhea, or hallucinations. If you plan on stopping the medication, your doctor may want you to reduce the dose gradually to reduce the severity of withdrawal effects.

It is important to take this medication exactly as prescribed by your doctor. If your doctor has told you to take this medication on a regular basis and you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take this medication if you:

are allergic to oxycodone, acetaminophen, or to any of the ingredients of the medication
have severely decreased liver function or active liver disease
have a seizure disorder
have pre-existing respiratory depression
have status asthmaticus (unresponsive asthma)
are pregnant, breast-feeding, or in labour
are taking or have taken (within the last 14 days) MAO inhibitors (e. g., phenelzine, tranylcypromine)
have a head injury
have a brain tumour
have acute alcoholism
have mild pain that can be controlled by occasional use of pain medications
have acute asthma or other obstructive airway diseases (e.g., chronic bronchitis, emphysema)
have cor pulmonale (heart failure caused by chronic high blood pressure in the arteries of the lungs)
have delirium tremens (e.g., confusion, diarrhea, shaking, fever, hallucinations, disorientation) associated with alcohol withdrawal
have increased cerebral spinal fluid pressure
have increased levels of carbon dioxide in the blood
have an abdominal condition that may require immediate surgery (e.g., appendicitis, pancreatitis)
have or may have bowel or digestive system problems (e.g., paralytic ileus), or may have a blockage in the digestive system

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

constipation
decreased ability or interest in sexual activity
decreased coordination
dizziness
drowsiness
headache
itching
lightheadedness or feeling faint
nausea
sweating
vomiting
weakness

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

blurred or double vision or other changes in vision
difficulty sleeping
dizziness when rising from a lying down or sitting position
dry mouth
fast, slow, or pounding heartbeat
loss of appetite
symptoms of withdrawal (e.g., nausea, vomiting, diarrhea, anxiety, shivering, cold and clammy skin, body aches, loss of appetite, sweating)

Stop taking the medication and seek immediate medical attention if any of the following occur:

convulsions (seizures)
signs of a bowel blockage (abdominal pain, nausea, severe constipation)signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of breathing problems (e.g., shallow, irregular breathing, or slow or troubled breathing)
signs of severe skin reactions (e. g., blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)
symptoms of overdose (e.g., cold, clammy skin, abnormally slow or weak breathing, severe dizziness, confusion, slow heartbeat, or extreme drowsiness)
symptoms of serotonin syndrome (e.g., confusion, fast heartbeat, hallucinations, restlessness, shaking, shivering, sudden jerking of muscles, sweating)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

February 19, 2021

Health Canada has issued new restrictions concerning the use of acetaminophen. To read the full Health Canada Advisory, visit Health Canada’s web site at https://recalls-rappels.canada.ca/en/alert-recall/unintentional-exposure-young-children-adult-acetaminophen-tablets-may-pose-serious

Abdominal conditions: Oxycodone may make the diagnosis of abdominal conditions more difficult or it may worsen these conditions. People with abdominal conditions such as inflammatory or obstructive bowel disease, acute cholecystitis, or pancreatitis should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Accidental use: When oxycodone – acetaminophen is used by anyone other than the person for whom it was prescribed, the effects of the medication may be fatal. Children are especially at risk. Keep this medication out of sight and reach of children.

Alcohol and other medications that cause drowsiness: People taking this medication should not combine it with alcohol, and should avoid combining it with other medications that cause drowsiness or slow down your breathing (e.g., antidepressants, sleeping pills, anxiety medications). Doing so can cause additive drowsiness and reduced breathing, as well as other side effects, which can be dangerous and possibly fatal.

Breathing: Oxycodone can suppress breathing. People at risk for breathing difficulties, such as asthma, should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Dependence and withdrawal: This medication contains oxycodone. Physical dependence, psychological dependence, and abuse have occurred with the use of oxycodone. People with a history of past or current substance use problems may be at greater risk of developing abuse or addiction while taking this medication. Abuse is not a problem with people who require this medication for pain relief. If this medication is stopped suddenly, you may experience withdrawal symptoms such as anxiety, sweating, trouble sleeping, shaking, pain, nausea, tremors, diarrhea, and hallucinations. If you have been taking this medication for a while, it should be stopped gradually as directed by your doctor.

Drowsiness/reduced alertness: This medication may cause drowsiness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how this medication affects you.

Head injury: People with head injuries or increased pressure in the head may have a higher risk of experiencing side effects (breathing problems) or worsening of their condition while taking this medication. These people should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: Decreased kidney function can cause this medication to build up in the body, causing side effects. If you have kidney disease or reduced kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Acetaminophen can cause severe and potentially fatal liver damage. Acetaminophen is a common ingredient in many non-prescription medications for colds and flu, pain, arthritis, and fever. Check the product label on all the medications you are taking to make sure that you are not exceeding the recommended dose of acetaminophen. An overdose of acetaminophen can lead to potentially fatal liver damage.

Contact your doctor immediately if you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin.

Low blood pressure: This medication can make low blood pressure worse or cause low blood pressure, which may be severe. If you experience severe dizziness, especially when standing from a lying or sitting position, contact your doctor.

Other medical conditions: People about to undergo surgery of the biliary tract should use caution while taking oxycodone as it may worsen their condition. Oxycodone will worsen the effects of acute alcohol intoxication and delirium tremens.

As well, people with an irregular heart rhythm, low blood pressure, low thyroid (hypothyroidism), Addison’s disease, benign prostatic hypertrophy (enlarged prostate), urethral stricture, decreased function of the adrenal glands, or porphyria should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Seizures: This medication may cause seizures, especially when higher doses are used or when taken with other medications that may increase the risk of seizures. The risk of seizures is also higher for people with epilepsy, a history of seizures, or who are at risk of seizures (e.g., people with head trauma).

Serotonin Syndrome: Although rare, severe reactions are possible when oxycodone is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat depression. These combinations should be avoided if possible. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation. Coma and death are possible.

If you are taking antidepressants, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. Infants born to mothers who have taken oxycodone during pregnancy have been born with signs of narcotic withdrawal. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking oxycodone and acetaminophen, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using full-strength oxycodone – acetaminophen have not been established for children under 18 years of age.

Seniors: Seniors who take this medication may be more likely to experience side effects or worsening of preexisting medical conditions.

What other drugs could interact with this medication?

There may be an interaction between oxycodone – acetaminophen and any of the following:

acetazolamide
aclidinium
alcohol
amphetamines (e. g., dextroamphetamine, lisdexamfetamine)
anesthetics
antihistamines (e.g., bilastine, cetirizine, dimenhydrinate, diphenhydramine, hydroxyzine, rupatadine)
antipsychotics (e.g., haloperidol, quetiapine, olanzapine, perphenazine, risperidone, thioridazine)
aprepitant
atropine
azelastine
“azole” antifungal medications (e.g., fluconazole, itraconazole, ketoconazole)
barbiturates (e.g., butalbital, phenobarbital)
benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
benztropine
bosentan
brimonidine
buprenorphine
bupropion
buspirone
butorphanol
cannabis
chloral hydrate
clidinium
cobicistat
conivaptan
diuretics (e.g., amiloride, bumetanide, furosemide, hydrochlorothiazide)
desmopressin
diltiazem
diphenoxylate
disopyramide
domperidone
dronedarone
efavirenz
etravirine
eluxadoline
entacapone
enzalutamide
eplerenone
esketamine
fesoterodine
flibanserin
flunarizine
glycopyrrolate
grapefruit juice
HIV protease inhibitors (e. g., darunavir, indinavir, lopinavir, ritonavir saquinavir)
ipratropium
isoniazid
kava kava
lemborexant
letermovir
lidocaine
linezolid
lithium
macrolide antibiotics (e.g., clarithromycin, erythromycin,)
methylene blue
metoclopramide
mifepristone
mirabegron
mirtazapine
modafinil
monoamine oxidase inhibitors (MAOIs; e.g., tranylcypromine, phenelzine, moclobemide, rasagiline, selegiline)
muscle relaxants (e.g., baclofen, methocarbamol, orphenadrine)
naltrexone
other narcotic analgesics (e.g., fentanyl, codeine, morphine)
oxybutynin
pegvisomant
phenylephrine
pomalidomide
pregabalin
protein kinase inhibitors (e.g., ceritinib, crizotinib, dabrafenib, dasatinib, imatinib, nilotinib)
quinidine
rifabutin
rifampin
ropinirole
rotigotine
St. John’s wort
scopolamine
seizure medications (e.g., carbamazepine, felbamate, lamotrigine, levetiracetam, phenytoin, primidone, topiramate, vigabatrin)
selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, sertraline)
serotonin/norepinephrine reuptake inhibitors (e.g., desvenlafaxine, duloxetine, venlafaxine)
sodium oxybate
somatostatin analogues (e.g., lanreotide, octreotide, pasireotide)
tetrabenazine
tiotropium
tizanidine
trazodone
tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine)
tryptophan
valerian
verapamil
warfarin
zolpidem
zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Endocet

Endocet vs Percocet: Key Differences and Similarities – Drug Vs.

Friend

Home >> Drug Vs. Friend >> Endocet vs Percocet: Key Differences and Similarities

Drug Vs. Friend

Endocet and Percocet are two brand names for a combination of acetaminophen and oxycodone. This combination drug is often prescribed for moderate to severe pain that is not relieved by other treatments.

Acetaminophen is a non-steroidal anti-inflammatory drug (NSAID) that relieves pain and inflammation by reducing the production of prostaglandins. Oxycodone is an opioid that binds to mu receptors in the brain. This combination provides a powerful pain reliever, relieving pain from injuries, surgeries, and other conditions.