How is erythromycin ophthalmic ointment applied. What are the proper steps for using erythromycin eye ointment. When should you use erythromycin ointment for eye infections. What precautions should be taken when applying erythromycin ophthalmic ointment.

Understanding Erythromycin Ophthalmic Ointment

Erythromycin ophthalmic ointment is a powerful medication used to treat and prevent bacterial eye infections. As a macrolide antibiotic, it effectively combats various bacterial strains that can affect the eyes. Its primary function is to eliminate harmful bacteria, making it an essential tool in ophthalmological care.

This medication is particularly valuable in two key scenarios:

• Treating existing bacterial eye infections in patients of all ages
• Preventing potential eye infections in newborn babies, typically administered shortly after birth

Understanding the proper use of erythromycin ophthalmic ointment is crucial for its effectiveness and safety. Let’s delve deeper into its application, benefits, and important considerations.

Proper Application Techniques for Erythromycin Eye Ointment

Applying eye ointment correctly ensures maximum effectiveness and minimizes the risk of complications. Here’s a step-by-step guide to properly apply erythromycin ophthalmic ointment:

1. Wash your hands thoroughly with soap and water to prevent introducing additional bacteria to your eyes.
2. Use a mirror or ask someone to help you apply the ointment for better precision.
3. Tilt your head slightly forward to create a natural pocket in your lower eyelid.
4. Gently pull down your lower eyelid with your index finger to expose the inner surface.
5. Hold the tube close to your eye without touching it to maintain sterility.
6. Squeeze a small amount of ointment (about 1 cm or 1/2 inch) into the pocket formed by your lower eyelid.
7. Look downward and gently close your eyes for 1-2 minutes to allow the medication to spread and absorb.
8. Use a clean tissue to wipe away any excess ointment from your eyelids and lashes.
9. Wash your hands again to remove any residual medication.

Is blurry vision normal after applying the ointment? Yes, it’s common to experience temporary blurred vision after application. Avoid activities requiring clear vision until your sight returns to normal.

Dosage and Frequency of Erythromycin Ophthalmic Ointment

The appropriate dosage and frequency of erythromycin ophthalmic ointment application can vary depending on the specific condition being treated and the patient’s age. However, some general guidelines include:

• For eye infections: Apply the ointment up to six times daily, or as directed by your healthcare provider.
• For newborn infection prevention: A single application is typically administered in the hospital shortly after birth.

Always follow your doctor’s instructions regarding dosage and duration of treatment. Continuing the full course of medication is crucial, even if symptoms improve, to prevent antibiotic resistance and ensure complete eradication of the infection.

What if you miss a dose?

If you forget to apply a dose, apply it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed application and continue with your regular schedule. Never double up on doses to compensate for a missed one.

Precautions and Considerations When Using Erythromycin Eye Ointment

While erythromycin ophthalmic ointment is generally safe and effective, there are several important precautions and considerations to keep in mind:

• Allergies: Inform your healthcare provider about any allergies, especially to erythromycin or other antibiotics.
• Pregnancy and breastfeeding: Discuss the risks and benefits with your doctor if you’re pregnant or nursing.
• Other medications: Disclose all current medications, including over-the-counter drugs and supplements, to avoid potential interactions.
• Contact lenses: Avoid wearing contact lenses during treatment for eye infections.
• Proper storage: Keep the medication tightly closed and store it as directed on the label.

Can erythromycin ophthalmic ointment be used for other purposes? While primarily used for bacterial eye infections, always consult your healthcare provider before using this medication for any off-label purposes.

Potential Side Effects of Erythromycin Ophthalmic Ointment

Like all medications, erythromycin eye ointment may cause side effects in some individuals. Most side effects are mild and temporary, but it’s important to be aware of potential reactions:

• Redness of the eye
• Itching or mild burning sensation
• Temporary stinging upon application
• Blurred vision (usually brief and resolves on its own)

While these side effects are generally not cause for concern, contact your healthcare provider if they persist or worsen. Severe allergic reactions are rare but require immediate medical attention. Symptoms of a serious allergic reaction may include:

• Severe eye pain or irritation
• Swelling of the eye or surrounding area
• Difficulty breathing or swallowing
• Rash or hives

Should you experience any severe or unusual symptoms while using erythromycin ophthalmic ointment, seek medical help promptly.

Erythromycin Ophthalmic Ointment for Newborns

The use of erythromycin ophthalmic ointment in newborns is a standard preventive measure in many countries. This practice, known as ocular prophylaxis, aims to prevent neonatal conjunctivitis caused by bacteria that may be present in the birth canal.

Why is erythromycin ointment used for newborns?

Newborns can contract eye infections during the birthing process, potentially leading to serious complications if left untreated. Erythromycin ointment acts as a protective barrier, killing harmful bacteria before they can cause an infection.

How is it administered to newborns?

The application process for newborns is similar to that for adults, but with extra care:

1. A healthcare professional applies the ointment shortly after birth, typically within the first hour.
2. A small amount of ointment is placed in each of the baby’s eyes.
3. The eyelids are gently massaged to spread the ointment evenly.

This single application is usually sufficient to provide the necessary protection against potential bacterial infections.

Comparing Erythromycin to Other Ophthalmic Antibiotics

While erythromycin is a widely used and effective ophthalmic antibiotic, it’s not the only option available for treating eye infections. Understanding how it compares to other medications can help patients and healthcare providers make informed decisions about treatment.

Erythromycin vs. Tetracycline

Both erythromycin and tetracycline are broad-spectrum antibiotics used in ophthalmic preparations. Key differences include:

• Spectrum of activity: Erythromycin may be more effective against certain gram-positive bacteria.
• Stability: Erythromycin is generally more stable and has a longer shelf life.
• Side effects: Tetracycline may cause more staining of the eyes in some cases.

Erythromycin vs. Tobramycin

Tobramycin is another commonly prescribed ophthalmic antibiotic. Comparing the two:

• Bacterial coverage: Tobramycin may be more effective against certain gram-negative bacteria.
• Formulation: Tobramycin is available in both ointment and drop forms, while erythromycin is typically an ointment.
• Frequency of use: Tobramycin often requires less frequent application.

Is one antibiotic better than the others? The choice of antibiotic depends on various factors, including the specific bacteria causing the infection, patient allergies, and local resistance patterns. Your healthcare provider will determine the most appropriate treatment for your individual case.

Long-term Use and Antibiotic Resistance Concerns

While erythromycin ophthalmic ointment is highly effective for treating and preventing bacterial eye infections, it’s crucial to understand the potential implications of long-term use and the growing concern of antibiotic resistance.

Risks of prolonged use

Extended use of any antibiotic, including erythromycin, can lead to several issues:

• Disruption of the eye’s natural bacterial flora
• Increased risk of fungal infections
• Development of antibiotic-resistant bacteria

Antibiotic resistance

Antibiotic resistance occurs when bacteria evolve to survive the effects of antibiotics. This can make infections harder to treat and potentially more dangerous. To minimize the risk of antibiotic resistance:

• Use erythromycin ophthalmic ointment only as prescribed
• Complete the full course of treatment, even if symptoms improve
• Avoid using leftover antibiotics from previous infections
• Practice good hygiene to prevent the spread of infections

How can healthcare providers address antibiotic resistance concerns? Implementing antibiotic stewardship programs, educating patients about proper use, and researching new antimicrobial agents are crucial steps in combating antibiotic resistance.

By understanding the proper application, benefits, and potential risks associated with erythromycin ophthalmic ointment, patients and healthcare providers can ensure its safe and effective use in treating and preventing bacterial eye infections. Always consult with a healthcare professional for personalized advice and treatment recommendations.

Erythromycin Ophthalmic: MedlinePlus Drug Information

pronounced as (e rith” roe mye’ sin)

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Ophthalmic erythromycin is used to treat bacterial infections of the eye. This medication is also used to prevent bacterial infections of the eye in newborn babies. Erythromycin is in a class of medications called macrolide antibiotics. It works by killing bacteria that cause infections.

Ophthalmic erythromycin comes as an ointment to apply to the eyes. It is usually applied up to six times a day for eye infections. Ophthalmic erythromycin is usually applied one time in the hospital soon after delivery to prevent eye infections in newborn babies. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use erythromycin eye ointment exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

You should expect your symptoms to improve during your treatment. Call your doctor if your symptoms get worse or do not go away, or if you develop other problems with your eyes during your treatment.

To use the eye ointment, follow these steps:

1. Wash your hands thoroughly with soap and water.
2. Use a mirror or have someone else apply the ointment.
3. Avoid touching the tip of the tube against your eye or anything else. The ointment must be kept clean.
4. Tilt your head forward slightly.
5. Holding the tube between your thumb and index finger, place the tube as near as possible to your eyelid without touching it.
6. Brace the remaining fingers of that hand against your cheek or nose.
7. With the index finger of your other hand, pull the lower lid of your eye down to form a pocket.
8. Place a small amount of ointment into the pocket made by the lower lid and the eye. A 1-centimeter (about 1/2-inch) strip of ointment usually is enough unless otherwise directed by your doctor.
9. Look downward, then gently close your eyes and keep them closed for 1 to 2 minutes to allow the medication to be absorbed.
10. Replace and tighten the cap right away.
11. Wipe off any excess ointment from your eyelids and lashes with a clean tissue. Do not rub your eyes, even if your vision is blurry. Wash your hands again.

Use ophthalmic erythromycin until you finish the prescription, even if you feel better. If you stop using ophthalmic erythromycin too soon, your infection may not be completely cured and the bacteria may become resistant to antibiotics.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using erythromycin eye ointment,

• tell your doctor and pharmacist if you are allergic to erythromycin, any other medications, or any of the ingredients in erythromycin eye ointment. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any other eye medications.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using erythromycin eye ointment, call your doctor.
• you should know that your vision may be blurry for a short amount of time after using the eye ointment. Wait until you can see normally before you drive or do other activities that require good vision.
• tell your doctor if you wear soft contact lenses. You should not wear contact lenses if you have an eye infection.

Unless your doctor tells you otherwise, continue your normal diet.

Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra ointment to make up for a missed dose.

Erythromycin eye ointment may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• redness, itching, stinging, or burning of the eye

Erythromycin eye ointment may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www. fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze erythromycin eye ointment.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

• Ilotycin^® Opthalmic^¶
• Romycin^® Ophthalmic

^¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 01/15/2017

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Erythromycin ophthalmic Uses, Side Effects & Warnings

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Generic name: erythromycin ophthalmic [ e-RITH-row-MYE-sin-off-THAL-mik ]
Brand names: Eyemycin, Ilotycin, Roymicin
Dosage form: ophthalmic ointment (0. 5%)
Drug class: Ophthalmic anti-infectives

Medically reviewed by Drugs.com on Aug 19, 2022. Written by Cerner Multum.

What is erythromycin ophthalmic?

Erythromycin is an antibiotic that fights bacteria.

Erythromycin ophthalmic (for the eyes) is used to treat bacterial infections of the eyes.

Erythromycin ophthalmic may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use erythromycin ophthalmic if you are allergic to erythromycin.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I use erythromycin ophthalmic?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Wash your hands before using eye medication.

To apply the ointment:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the ointment tube with the tip pointing toward this pocket. Look up and away from the tip.

• Squeeze out a ribbon of ointment into the lower eyelid pocket without touching the tip of the tube to your eye. Blink your eye gently and then keep it closed for 1 or 2 minutes.

• Use a tissue to wipe excess ointment from your eyelashes.

• After opening your eyes, you may have blurred vision for a short time. Avoid driving or doing anything that requires you to be able to see clearly.

Do not touch the tip of the ointment tube or place it directly on your eye. A contaminated tube tip can infect your eye, which could lead to serious vision problems.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Erythromycin ophthalmic will not treat a viral or fungal eye infection.

Store at room temperature away from moisture and heat. Keep the tube tightly closed when not in use.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using erythromycin ophthalmic?

erythromycin ophthalmic may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Do not use other eye medications unless your doctor tells you to.

Erythromycin ophthalmic side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Erythromycin ophthalmic may cause serious side effects. Stop using erythromycin ophthalmic and call your doctor at once if you have:

• severe burning, stinging, or irritation after using this medicine; or

• signs of eye infection–pain, swelling, severe discomfort, crusting or drainage, eyes more sensitive to light.

Common side effects of erythromycin ophthalmic may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect erythromycin ophthalmic?

Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

More about erythromycin ophthalmic

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• Side effects
• Drug class: ophthalmic anti-infectives
• Breastfeeding
• En español

Patient resources

• Advanced Reading

Other brands

Ilotycin, Eyemycin, Roymicin

Professional resources

• Prescribing Information

Related treatment guides

• Conjunctivitis, Bacterial

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 7.01.

Arpimed

Dosage form

Ointment for external use.

Composition

Each gram contains:

active 011 substances o : erythromycin – 10 mg;

auxiliary substances : liquid paraffin, propylparaben, white petrolatum, ethanol

Pharmacological and ATC code

Macrolide antibiotic for external use. ATX code – D10AF02.

Pharmacological action

Macrolide antibiotic with a bacteriostatic effect. When applied externally, it has an anti-acne effect due to the bacteriostatic effect on the microorganisms that cause acne: Propionibacterium acnes.

Reversibly binds to the 50S subunit of ribosomes, which disrupts the formation of peptide bonds between amino acid molecules and blocks the synthesis of proteins in microorganisms (does not affect the synthesis of nucleic acids).

When used in high doses, depending on the type of pathogen, it may also exhibit a bactericidal effect.

Pharmacokinetics

Only a small part of erythromycin undergoes systemic absorption, which is subsequently excreted from the body in the urine.

Indications for use

• Treatment of acne vulgaris (mainly papular and pustular).
• Purulent-inflammatory diseases of the skin.

Application

The ointment is applied no more than 2 times a day on previously cleaned affected skin areas. Treatment is continued until clinical improvement, on average 1-3 months.

Adverse reactions

Local reactions : sometimes there may be a burning sensation, irritation, dryness of the skin at the site of application of the drug. As a rule, these phenomena are mild and do not require discontinuation of the drug and / or symptomatic therapy

Allergic reactions : generalized urticaria, irritation, redness, epidermal desquamation, skin erythema, eye irritation.

Contraindications

Hypersensitivity to erythromycin and other macrolides.

Pregnancy and lactation

The use of the drug during pregnancy and lactation is undesirable and is possible only if the intended benefit outweighs the risk of side effects.

Special instructions

Avoid getting the drug on the mucous membranes and sensitive areas of the skin (eyelids, neck, supraclavicular cavity).

Use of another topical anti-acne preparation is possible no earlier than one hour later.

If generalized urticaria occurs, treatment should be discontinued and systemic corticosteroids given.

Wash hands thoroughly after each use.

In case of infection, the drug should be discontinued and appropriate therapy instituted.

When using the drug, the development of cross-resistance to other antibiotics of the macrolide group, lincomycin, clindamycin is possible.

Propionibacterium strains are becoming more resistant to antibiotics. To prevent the development of resistance during treatment with Erythromycin topical ointment, the patient should not use other oral antibiotics. The patient should not use the drug for a longer time than necessary, however, treatment should continue for at least 6 months.

Pediatric use: The safety and efficacy of erythromycin ointment in pediatric use has not been established.

Overdose

Accidental overdose is unlikely due to the nature of the local application of the drug.

Drug Interactions

Co-administration of erythromycin with drugs that cause epidermal desquamation (eg, benzoyl peroxide, tretinoin, resorcinol, salicylic acid, sulfur) may increase side effects.

Concomitant use of another topical antibiotic is contraindicated.

Erythromycin should not be used simultaneously with drugs that cause skin desquamation, as well as with cosmetic and hygiene products that cause dryness and irritation of the skin.

Erythromycin should not be co-administered with clindamycin as they bind competitively to the 50S subunit of the ribosome.

Product form

1% ointment for external use in aluminum tubes of 20 and 25 g, together with a leaflet in a cardboard pack.

Shelf life

3 years. Do not use after the expiration date.

Storage conditions

Keep out of the reach of children, dry, dark place at a temperature not exceeding 15 ⁰ C.

instructions for use, price, analogues, composition, indications

1 g of ointment contains:

Active substance: erythromycin – 0.01 g

Excipients: anhydrous lanolin, sodium metabisulphite, petroleum jelly.

Erythromycin belongs to the group of macrolide antibiotics. When applied topically, it has an antibacterial effect.

Excreted by the intestines and kidneys.

Treatment of superficial eye infections caused by microorganisms susceptible to erythromycin.

Prevention of ophthalmia in newborns (neonatal conjunctivitis) caused by Neisseria gonorrhoeae (neonatal gonococcal conjunctivitis) or Chlamydia trachomatis.

The efficacy of erythromycin in the prevention of ophthalmia caused by penicillinase-producing N. gonorrhoeae has not been established.

Hypersensitivity to the components of the drug, severe violations of the liver and kidneys, history of jaundice.

With care

Old age, impaired liver and kidney function.

Excess ointment on the eyes can be removed with warm water. Do not apply ointment until the next application.

Taking into account the characteristics of this medicinal product, no toxic effects are expected from its use in ophthalmology, as well as from accidental ingestion of the contents of the tube.

In the prevention of neonatal ophthalmia, erythromycin ophthalmic ointment should not be washed out of the eye.

In children whose mothers have clinically pronounced gonorrhea, erythromycin, as an ophthalmic drug, is used simultaneously with an aqueous solution of penicillin G for parenteral use.

The preparation contains lanolin, which may cause local skin reactions (eg contact dermatitis).

When using this drug for a long time or in large quantities, the development of other, non-susceptible microorganisms, including fungi, is possible. Consult your physician if symptoms worsen or recur.

During an eye infection, the use of contact lenses (hard or soft) is not recommended.

If you are pregnant or breastfeeding, think you are pregnant or are planning to become pregnant, ask your doctor before taking this medicine. The use of this drug during pregnancy is not recommended.

During lactation, it is necessary to either stop treatment or suspend breastfeeding, based on the benefits of breastfeeding for the child and the benefits of treatment for the mother.

Patients who temporarily lose their vision after the application are not recommended to drive a vehicle or work with complex machinery, machines or any other complex equipment that requires clarity of vision immediately after using the drug.

Temporary visual disturbances after instillation of the ointment into the conjunctival sac may affect the ability to drive vehicles or work with other mechanisms. If these effects occur, the patient should wait until vision is clear before driving or operating machinery.

No clinically significant interactions have been described.

It is known that erythromycin is incompatible with lincomycin, clindamycin and chloramphenicol (antagonism).

Reduces the bactericidal effect of beta-lactam antibiotics (penicillins, cephalosporins, carbapenems).

Pharmaceutically incompatible with aminoglycosides. When used with glucocorticosteroids, it leads to an increase in their effect.

If you are taking any other medicines, be sure to tell your doctor!

locally. For adults, including elderly patients, and children, a strip of ointment 0.5-1 cm long is placed behind the lower eyelid from 1 to 6 times a day, depending on the severity of the infection.

The duration of treatment for neonatal ophthalmia, bacterial conjunctivitis, blepharitis, blepharoconjunctivitis, meibomitis, with complex therapy of keratitis depends on the form and severity of the disease, but should not exceed 14 days.

In the treatment of trachoma – 4-5 times a day, the treatment should be combined with the opening of the follicles. When the inflammatory process subsides, the drug is used 2-3 times a day. The duration of treatment for trachoma is up to 4 months.

In the treatment of chlamydial conjunctivitis, the ointment is placed in the conjunctival sac 4-5 times a day, the duration of treatment depends on the severity of the disease, up to 3 months.

For the prevention of blennorrhea in newborns, a strip of ointment 0.5-1 cm long is placed behind the lower eyelid once.

Peculiarities of application in certain groups of patients

Use in hepatic and renal insufficiency

The safety and efficacy of this medicinal product in patients with hepatic or renal insufficiency have not been established.

Children

For the prevention of ophthalmia in newborns, the ointment is used once.

Elderly patients

There are no specific recommendations for use.

How to use

The ointment is placed in the conjunctival sac. With your head tilted back, lower the lower eyelid and apply 0.5-1 cm of ointment, looking up. Gently close your eyes and keep them closed for a few seconds.

If more than one ophthalmic agent is used, an interval of at least 5 minutes must be observed. Eye ointments should be administered last.

Do not touch the eye or any surface with the tip of the tube to avoid contamination of the contents of the tube.

Like all medicines, Erythromycin ophthalmic ointment can cause side effects, although not everybody gets them.

The following adverse reactions were observed in the post-registration period of the use of the medicinal product, the frequency of which is unknown (cannot be estimated from the available data): hypersensitivity reactions, including urticaria, burning sensation, hyperemia, irritation of the mucous membrane of the eye, blurred vision.

Adverse reactions reported:

If you experience any adverse reactions, please consult your physician. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the adverse drug reactions (actions) information database, including reports of drug failures. By reporting adverse reactions, you help to get more information about the safety of the drug.

At a temperature not higher than 25°C.