How does Lexapro affect weight. What are the potential side effects of escitalopram on appetite. Can Lexapro cause weight gain or loss. What factors influence weight changes while taking SSRIs. How to manage weight fluctuations on antidepressants.

The Mechanism of Lexapro and Its Influence on Body Weight

Lexapro, known generically as escitalopram, is a selective serotonin reuptake inhibitor (SSRI) prescribed for treating anxiety and depression. Its primary function is to increase serotonin levels in the brain, which can have a cascading effect on various bodily functions, including appetite regulation. This intricate relationship between Lexapro and the body’s metabolic processes can lead to changes in weight for some individuals.

The drug’s impact on weight is not uniform across all users. While some may experience weight gain, others might notice weight loss or no significant change at all. The variability in responses underscores the complexity of how SSRIs interact with individual physiology and lifestyle factors.

How Does Lexapro Affect Appetite?

Lexapro’s influence on appetite can be attributed to its effect on serotonin, a neurotransmitter that plays a crucial role in regulating mood and appetite. By increasing serotonin levels, Lexapro may:

• Alter hunger signals in the brain
• Affect metabolism and energy expenditure
• Influence food preferences and cravings
• Impact satiety and fullness sensations

These effects can vary greatly from person to person, leading to diverse outcomes in terms of weight changes.

Clinical Evidence: Lexapro’s Effects on Weight

Research on Lexapro’s impact on weight has yielded mixed results, reflecting the drug’s complex interactions with individual physiology. A comprehensive analysis of available studies reveals:

• A 2014 study found that the average weight gain for Lexapro users was less than 0.5%
• A 2018 review reported an average weight gain of 3.7% with Lexapro use
• Some studies suggest that weight changes may be more pronounced in children and adolescents
• Individual factors such as age, gender, and initial BMI can influence weight outcomes

These findings highlight the importance of personalized medicine and close monitoring when prescribing Lexapro.

Are Weight Changes Clinically Significant?

The clinical significance of weight changes associated with Lexapro use is a subject of ongoing debate. While some studies suggest that weight fluctuations are generally modest, the impact on individual patients can vary. Factors to consider include:

• The duration of treatment
• Pre-existing health conditions
• Individual susceptibility to weight changes
• The psychological impact of weight fluctuations on the patient

Healthcare providers must weigh these factors against the therapeutic benefits of Lexapro when making treatment decisions.

Risk Factors for Weight Gain on Lexapro

While not all individuals taking Lexapro will experience weight gain, certain risk factors may increase the likelihood of this side effect. Identifying these factors can help patients and healthcare providers anticipate and manage potential weight changes:

• Sedentary lifestyle
• Smoking habits
• Diet high in processed foods and refined carbohydrates
• Genetic predisposition to weight gain
• Age and gender (young men may be at higher risk)
• Low initial BMI

Understanding these risk factors empowers patients to make informed decisions about their treatment and lifestyle choices while taking Lexapro.

Comparing Lexapro to Other Antidepressants: Weight Impact

When considering antidepressant options, it’s crucial to understand how Lexapro compares to other medications in terms of weight-related side effects. Research has shown that:

• SSRIs like Lexapro generally have a lower risk of weight gain compared to older antidepressants
• Within the SSRI class, weight gain potential can vary
• Some antidepressants, such as bupropion, may be associated with weight loss
• Tricyclic antidepressants and monoamine oxidase inhibitors often have more significant weight gain effects

These comparisons can guide healthcare providers in selecting the most appropriate medication based on a patient’s individual needs and risk factors.

How Do Different Antidepressants Affect Weight?

The impact of antidepressants on weight can vary significantly across different drug classes and even within the same class. Here’s a brief overview of weight effects associated with various antidepressants:

• SSRIs (including Lexapro): Generally modest weight changes, with some variability
• SNRIs (e.g., venlafaxine): Similar to SSRIs, with potentially less weight gain
• Bupropion: Often associated with weight loss or weight neutrality
• Mirtazapine: Higher likelihood of weight gain
• Tricyclic antidepressants: Frequently associated with more significant weight gain

This diversity in weight effects underscores the importance of individualized treatment approaches in managing depression and anxiety.

Managing Weight Changes While Taking Lexapro

For individuals concerned about potential weight changes while taking Lexapro, several strategies can help maintain a healthy weight:

1. Regular monitoring of weight and body composition
2. Adopting a balanced, nutrient-rich diet
3. Engaging in regular physical activity
4. Staying hydrated and limiting alcohol consumption
5. Getting adequate sleep and managing stress
6. Working closely with healthcare providers to adjust treatment if necessary

Implementing these strategies can help mitigate unwanted weight changes and support overall well-being while taking Lexapro.

Can Lifestyle Modifications Offset Lexapro-Induced Weight Changes?

Lifestyle modifications can play a crucial role in managing weight while taking Lexapro. Evidence suggests that:

• Regular exercise can help maintain a stable weight and improve mood
• A balanced diet rich in fruits, vegetables, and lean proteins may help regulate appetite
• Mindful eating practices can prevent overconsumption and emotional eating
• Stress reduction techniques may help manage weight indirectly by reducing cortisol levels

By incorporating these lifestyle changes, many individuals can effectively manage their weight while benefiting from Lexapro’s therapeutic effects.

The Role of Serotonin in Appetite and Weight Regulation

Serotonin, the neurotransmitter targeted by Lexapro, plays a complex role in regulating appetite and weight. Understanding this relationship can provide insights into why weight changes may occur with SSRI use:

• Serotonin influences satiety signals in the brain
• It can affect metabolism and energy expenditure
• Serotonin levels may influence food preferences and cravings
• The neurotransmitter is involved in regulating glucose and lipid metabolism

The intricate interplay between serotonin, appetite, and metabolism underscores the potential for SSRIs like Lexapro to influence weight in various ways.

How Does Serotonin Affect Eating Behavior?

Serotonin’s impact on eating behavior is multifaceted and can influence various aspects of food intake:

• Appetite regulation: Serotonin can suppress appetite by activating specific receptors in the brain
• Meal size and frequency: It may affect how much and how often a person eats
• Food choices: Serotonin levels can influence cravings for certain types of foods
• Emotional eating: As a mood regulator, serotonin can indirectly affect stress-related eating patterns

These effects highlight why medications that alter serotonin levels, like Lexapro, can potentially impact weight and eating habits.

Long-Term Weight Management on Lexapro

Managing weight over the long term while taking Lexapro requires a proactive approach. Patients and healthcare providers should consider:

• Regular check-ins to monitor weight trends
• Adjusting medication dosage if necessary
• Exploring alternative treatments if weight changes become problematic
• Implementing sustainable lifestyle modifications
• Addressing any underlying factors contributing to weight changes

Long-term success in weight management while on Lexapro often involves a combination of medical supervision and personal commitment to health-promoting behaviors.

Is Weight Gain on Lexapro Reversible?

For individuals who experience weight gain while taking Lexapro, a common concern is whether the changes are reversible. Research suggests that:

• Weight gain associated with Lexapro may stabilize over time
• Some individuals may lose weight after discontinuing the medication
• Lifestyle interventions can be effective in reversing weight gain
• The reversibility of weight changes can vary from person to person

It’s important to consult with a healthcare provider before making any changes to medication regimens, as abrupt discontinuation of Lexapro can lead to withdrawal symptoms.

The Psychological Impact of Weight Changes on Mental Health

Weight changes associated with Lexapro use can have significant psychological impacts, potentially affecting the very conditions the medication is intended to treat. Considerations include:

• Body image concerns and self-esteem issues
• Anxiety about health and long-term effects
• Potential exacerbation of eating disorders or disordered eating patterns
• Impact on treatment adherence and overall satisfaction with therapy

Addressing these psychological aspects is crucial for maintaining the overall effectiveness of Lexapro treatment and supporting patients’ mental health.

How Can Patients Cope with Weight-Related Concerns?

Coping with weight-related concerns while taking Lexapro requires a multifaceted approach:

• Open communication with healthcare providers about weight concerns
• Seeking support from mental health professionals or support groups
• Practicing self-compassion and focusing on overall health rather than just weight
• Engaging in activities that promote body positivity and self-acceptance
• Exploring cognitive-behavioral strategies to manage negative thoughts about weight

By addressing both the physical and emotional aspects of weight changes, patients can better navigate the challenges that may arise during Lexapro treatment.

Future Directions in Research and Treatment

As our understanding of the relationship between antidepressants and weight continues to evolve, several areas of research hold promise for improving patient outcomes:

• Personalized medicine approaches to predict individual responses to SSRIs
• Development of new antidepressants with fewer weight-related side effects
• Investigation of combination therapies to mitigate weight gain
• Exploration of genetic markers that may influence weight changes on SSRIs
• Long-term studies on the metabolic effects of antidepressant use

These research directions aim to enhance the efficacy of depression treatment while minimizing unwanted side effects like weight gain.

What Innovations Are on the Horizon for Managing Antidepressant-Related Weight Changes?

Emerging innovations in managing antidepressant-related weight changes include:

• Advanced pharmacogenetic testing to tailor medication choices
• Novel drug formulations designed to minimize weight impact
• Integration of wearable technology for real-time monitoring of metabolic changes
• Development of targeted nutritional interventions to support weight management
• Exploration of gut microbiome modulation to influence weight outcomes

These innovative approaches hold the potential to revolutionize how we address weight concerns in antidepressant therapy, ultimately improving patient care and treatment outcomes.

Lexapro and weight gain or loss: Facts and tips

Lexapro and weight gain or loss: Facts and tips

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Medically reviewed by Alan Carter, Pharm. D. — By Claire Sissons — Updated on December 22, 2022

Lexapro is the brand name for escitalopram, which doctors prescribe to treat anxiety and depression. It increases serotonin in the brain, which can affect your appetite and may lead to weight changes.

Lexapro belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). Doctors may prescribe it to treat mood disorders, such as depression and anxiety.

In this article, we look at how Lexapro can affect appetite and weight and some tips for managing weight change.

Lexapro’s prescribing information states that people using the drug to treat major depression may experience significant changes in weight and appetite. These include both increases and decreases.

The leaflet cites animal studies in which significant weight gain occurred. However, at least one study has suggested that adult humans are unlikely to see clinically significant changes, while children and adolescents using Lepraxo may have slower growth and weight gain.

The authors of a 2014 study concluded that various antidepressants could lead to weight gain, but the differences among them were relatively small. The average weight gain for people taking Lexapro was less than 0.5%.

The most significant weight gain occurred in young men and those whose body mass index (BMI) was low before starting treatment.

A 2018 review also compared weight changes with various antidepressants and concluded that the average weight gain with Lexapro was 3.7%. Weight gain with other options ranged from 1.1% with nortriptyline to 25.9% with amitriptyline.

Research from 2017 looked at the role of SSRIs in weight gain. The authors found that certain risk factors increased the likelihood of a person gaining weight when taking these antidepressants. These factors included:

• having a sedentary lifestyle
• smoking
• eating a diet high in processed meat, dairy, and refined carbohydrates

SSRIs may be less likely than older antidepressants — such as monoamine oxidase inhibitors and tricyclic antidepressants — to cause weight gain.

Meanwhile, the National Library of Medicine lists decreased appetite as a side effect of Lexapro and does not mention weight gain.

Why do antidepressants affect weight?

Experts do not know precisely why weight changes occur with antidepressant use.

One reason may be that they boost serotonin, which plays a role in managing appetite. The medication may increase appetite directly, or a person may begin to eat more as their depression or anxiety lessens.

Depression and anxiety can also affect eating habits — people may eat more or less than usual. Lifestyle remedies, such as changes in diet and exercise, may also affect a person’s appetite and weight.

More research is needed to identify what connection, if any, exists between SSRIs and weight gain.

SSRIs work by increasing the amount of serotonin in the brain. Serotonin is a hormone and neurotransmitter that helps regulate mood.

Lexapro comes as either a liquid or a pill. The dosage is usually 10 milligrams (mg) daily, taken either in the morning or the evening.

A person may notice an improvement in symptoms after 1–4 weeks, but they should continue taking the drug, or symptoms may return. People should not stop taking Lexapro without guidance from a doctor.

Medication affects everyone differently.

Anyone concerned about weight changes while taking Lexapro should speak with a doctor.

A doctor may do further tests to see if there is another reason for the change in weight. If there is no other reason, they may suggest an alternative treatment.

Other remedies for treating depression include:

• undergoing counseling
• exercising, such as walking at least 30 minutes each day
• following a varied diet and eating regular meals
• establishing or maintaining a regular sleep pattern
• connecting with others
• avoiding the use of alcohol, nicotine, and drugs that a doctor has not recommended

These measures can help a person feel better, and some may help manage weight.

Lexapro can cause other side effects, which may include:

• a dry mouth
• abdominal pain
• diarrhea or constipation
• heartburn
• feeling dizzy
• nausea
• feeling more tired or drowsy than usual
• changes in sex drive
• changes in urination
• sweating more than usual
• symptoms that are similar to flu, such as a runny nose or fever

If these side effects do not go away or are very severe, a person should seek medical advice.

Some side effects, including the following, can be serious and require urgent medical attention:

• worsening depression or thinking about or attempting suicide
• hallucinations
• agitation, racing thoughts, and unusually high energy levels, which are signs of mania
• a fast or irregular heartbeat, stiff or twitching muscles, confusion, and fever, which can indicate serotonin syndrome
• breathing difficulty, hives, and swelling, which may indicate an allergic reaction
• eye or vision changes

All SSRIs have slightly different side effects. If the side effects of an antidepressant are affecting a person’s quality of life, they might benefit from trying an alternative drug.

Learn more about Lexapro’s side effects.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

• Ask the tough question: “Are you considering suicide?”
• Listen to the person without judgment.
• Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
• Stay with the person until professional help arrives.
• Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Click here for more links and local resources.

Was this helpful?

Here are some answers to questions people often ask about Lexapro (escitalopram) and weight gain.

Can Lexapro cause rapid weight gain?

Lexapro may cause a small amount of weight gain. If rapid or dramatic weight gain occurs, a person should speak with their doctor.

How much weight do you gain on Lexapro?

The effects of Lexapro on weight will vary among individuals. A 2014 study found that the average weight gain was less than 0.5%, but a 2018 review put the average weight gain at 3.7%.

Does Lexapro slow your metabolism?

Metabolic changes can occur when a person has depression and is taking antidepressant medications. However, the relationships are complex, and there is not enough evidence to show that Lepraxo specifically affects metabolism.

How can I avoid gaining weight on Lexapro?

Ways of managing weight while taking Lepraxo include:

• following a varied diet with plenty of fresh ingredients
• avoiding high fat, high sugar foods
• eating regular meals and healthy snacks
• getting regular exercise
• receiving counseling to help manage both depression and weight issues

Anyone concerned about their weight should ask a healthcare professional about how to manage it.

Which foods can help manage depression?

Weight changes can occur when taking Lexapro, but they are not usually dramatic. In some cases, weight loss may occur. A doctor may monitor a child taking this drug for reduced growth rates and insufficient weight gain.

Anyone with concerns about weight gain while taking Lexapro may wish to seek advice from a doctor, who might offer an alternative medication.

A varied, balanced diet and regular exercise are also treatment options for depression and anxiety, and they can help manage weight changes.

Last medically reviewed on October 17, 2022

• Depression
• Obesity / Weight Loss / Fitness
• Pharmacy / Pharmacist
• Psychology / Psychiatry

How we reviewed this article:

Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

• Blumenthal, S. R., et al. (2014). An electronic health records study of long-term weight gain following antidepressant use.
  https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1878922
• Care for your health. (n.d.).
  http://www.mentalhealthamerica.net/care-your-health
• Depression: Overview. (2022).
  https://www.nimh.nih.gov/health/topics/depression#part_2257
• Eker, O. O., et al. (2017). Metabolic effects of antidepressant treatment.
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439472/
• Escitalopram. (2022).
  https://medlineplus.gov/druginfo/meds/a603005.html
• ESCITALOPRAM tablets, for oral use. (2020).
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=61f27814-bc32-4de5-b12a-29fe1ee9771e
• Gafoor, R. , et al. (2018). Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study.
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964332/
• Healthy diet: Eating with mental health in mind. (n.d.).
  http://www.mentalhealthamerica.net/conditions/healthy-diet-eating-mental-health-mind
• Shi, Z., et al. (2017). SSRI antidepressant use potentiates weight gain in the context of unhealthy lifestyles: Results from a 4-year Australian follow-up study.
  https://bmjopen.bmj.com/content/7/8/e016224

Share this article

Medically reviewed by Alan Carter, Pharm.D. — By Claire Sissons — Updated on December 22, 2022

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Lexapro and weight gain or loss: Facts and tips

Lexapro and weight gain or loss: Facts and tips

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Medically reviewed by Alan Carter, Pharm. D. — By Claire Sissons — Updated on December 22, 2022

Lexapro is the brand name for escitalopram, which doctors prescribe to treat anxiety and depression. It increases serotonin in the brain, which can affect your appetite and may lead to weight changes.

Lexapro belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). Doctors may prescribe it to treat mood disorders, such as depression and anxiety.

In this article, we look at how Lexapro can affect appetite and weight and some tips for managing weight change.

Lexapro’s prescribing information states that people using the drug to treat major depression may experience significant changes in weight and appetite. These include both increases and decreases.

The leaflet cites animal studies in which significant weight gain occurred. However, at least one study has suggested that adult humans are unlikely to see clinically significant changes, while children and adolescents using Lepraxo may have slower growth and weight gain.

The authors of a 2014 study concluded that various antidepressants could lead to weight gain, but the differences among them were relatively small. The average weight gain for people taking Lexapro was less than 0.5%.

The most significant weight gain occurred in young men and those whose body mass index (BMI) was low before starting treatment.

A 2018 review also compared weight changes with various antidepressants and concluded that the average weight gain with Lexapro was 3.7%. Weight gain with other options ranged from 1.1% with nortriptyline to 25.9% with amitriptyline.

Research from 2017 looked at the role of SSRIs in weight gain. The authors found that certain risk factors increased the likelihood of a person gaining weight when taking these antidepressants. These factors included:

• having a sedentary lifestyle
• smoking
• eating a diet high in processed meat, dairy, and refined carbohydrates

SSRIs may be less likely than older antidepressants — such as monoamine oxidase inhibitors and tricyclic antidepressants — to cause weight gain.

Meanwhile, the National Library of Medicine lists decreased appetite as a side effect of Lexapro and does not mention weight gain.

Why do antidepressants affect weight?

Experts do not know precisely why weight changes occur with antidepressant use.

One reason may be that they boost serotonin, which plays a role in managing appetite. The medication may increase appetite directly, or a person may begin to eat more as their depression or anxiety lessens.

Depression and anxiety can also affect eating habits — people may eat more or less than usual. Lifestyle remedies, such as changes in diet and exercise, may also affect a person’s appetite and weight.

More research is needed to identify what connection, if any, exists between SSRIs and weight gain.

SSRIs work by increasing the amount of serotonin in the brain. Serotonin is a hormone and neurotransmitter that helps regulate mood.

Lexapro comes as either a liquid or a pill. The dosage is usually 10 milligrams (mg) daily, taken either in the morning or the evening.

A person may notice an improvement in symptoms after 1–4 weeks, but they should continue taking the drug, or symptoms may return. People should not stop taking Lexapro without guidance from a doctor.

Medication affects everyone differently.

Anyone concerned about weight changes while taking Lexapro should speak with a doctor.

A doctor may do further tests to see if there is another reason for the change in weight. If there is no other reason, they may suggest an alternative treatment.

Other remedies for treating depression include:

• undergoing counseling
• exercising, such as walking at least 30 minutes each day
• following a varied diet and eating regular meals
• establishing or maintaining a regular sleep pattern
• connecting with others
• avoiding the use of alcohol, nicotine, and drugs that a doctor has not recommended

These measures can help a person feel better, and some may help manage weight.

Lexapro can cause other side effects, which may include:

• a dry mouth
• abdominal pain
• diarrhea or constipation
• heartburn
• feeling dizzy
• nausea
• feeling more tired or drowsy than usual
• changes in sex drive
• changes in urination
• sweating more than usual
• symptoms that are similar to flu, such as a runny nose or fever

If these side effects do not go away or are very severe, a person should seek medical advice.

Some side effects, including the following, can be serious and require urgent medical attention:

• worsening depression or thinking about or attempting suicide
• hallucinations
• agitation, racing thoughts, and unusually high energy levels, which are signs of mania
• a fast or irregular heartbeat, stiff or twitching muscles, confusion, and fever, which can indicate serotonin syndrome
• breathing difficulty, hives, and swelling, which may indicate an allergic reaction
• eye or vision changes

All SSRIs have slightly different side effects. If the side effects of an antidepressant are affecting a person’s quality of life, they might benefit from trying an alternative drug.

Learn more about Lexapro’s side effects.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

• Ask the tough question: “Are you considering suicide?”
• Listen to the person without judgment.
• Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
• Stay with the person until professional help arrives.
• Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Click here for more links and local resources.

Was this helpful?

Here are some answers to questions people often ask about Lexapro (escitalopram) and weight gain.

Can Lexapro cause rapid weight gain?

Lexapro may cause a small amount of weight gain. If rapid or dramatic weight gain occurs, a person should speak with their doctor.

How much weight do you gain on Lexapro?

The effects of Lexapro on weight will vary among individuals. A 2014 study found that the average weight gain was less than 0.5%, but a 2018 review put the average weight gain at 3.7%.

Does Lexapro slow your metabolism?

Metabolic changes can occur when a person has depression and is taking antidepressant medications. However, the relationships are complex, and there is not enough evidence to show that Lepraxo specifically affects metabolism.

How can I avoid gaining weight on Lexapro?

Ways of managing weight while taking Lepraxo include:

• following a varied diet with plenty of fresh ingredients
• avoiding high fat, high sugar foods
• eating regular meals and healthy snacks
• getting regular exercise
• receiving counseling to help manage both depression and weight issues

Anyone concerned about their weight should ask a healthcare professional about how to manage it.

Which foods can help manage depression?

Weight changes can occur when taking Lexapro, but they are not usually dramatic. In some cases, weight loss may occur. A doctor may monitor a child taking this drug for reduced growth rates and insufficient weight gain.

Anyone with concerns about weight gain while taking Lexapro may wish to seek advice from a doctor, who might offer an alternative medication.

A varied, balanced diet and regular exercise are also treatment options for depression and anxiety, and they can help manage weight changes.

Last medically reviewed on October 17, 2022

• Depression
• Obesity / Weight Loss / Fitness
• Pharmacy / Pharmacist
• Psychology / Psychiatry

How we reviewed this article:

Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

• Blumenthal, S. R., et al. (2014). An electronic health records study of long-term weight gain following antidepressant use.
  https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1878922
• Care for your health. (n.d.).
  http://www.mentalhealthamerica.net/care-your-health
• Depression: Overview. (2022).
  https://www.nimh.nih.gov/health/topics/depression#part_2257
• Eker, O. O., et al. (2017). Metabolic effects of antidepressant treatment.
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439472/
• Escitalopram. (2022).
  https://medlineplus.gov/druginfo/meds/a603005.html
• ESCITALOPRAM tablets, for oral use. (2020).
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=61f27814-bc32-4de5-b12a-29fe1ee9771e
• Gafoor, R. , et al. (2018). Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study.
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964332/
• Healthy diet: Eating with mental health in mind. (n.d.).
  http://www.mentalhealthamerica.net/conditions/healthy-diet-eating-mental-health-mind
• Shi, Z., et al. (2017). SSRI antidepressant use potentiates weight gain in the context of unhealthy lifestyles: Results from a 4-year Australian follow-up study.
  https://bmjopen.bmj.com/content/7/8/e016224

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Medically reviewed by Alan Carter, Pharm.D. — By Claire Sissons — Updated on December 22, 2022

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dullness of emotions, swelling, weight gain, decreased libido

Medicine and health

03.10.22

Reader Experience

These are community reader comments. Collected into one material, carefully edited and formatted according to editorial standards.

Julia Konyakhina

collected stories

Author profile

Antidepressants can cause unpleasant symptoms, especially at the beginning of treatment.

Most of them are not dangerous and weaken after a few weeks. But some pass only after completion of therapy or a change in the drug. We asked readers to tell us what side effects of antidepressants they had to deal with and how they coped with it.

Go to the doctor

There are no recommendations for treatment in the article, only personal experience of readers. Please consult with your doctor before deciding on treatment. The responsibility for your health rests solely with you.

Side effect No. 1

Dullness of emotions

Ksenia M
completed treatment

She took Paxil antidepressant in combination with an antipsychotic. In the first week of therapy, there were very strange sensations: emotions and feelings became dull, it seemed that I was in a vacuum.

There was also a strong thirst, libido dropped below the baseboard, I constantly wanted to sleep. A month later, the side effects disappeared, and after three months, the first improvements in mental state appeared.

Totally treated with an antidepressant for a year, after completion of therapy, there was no withdrawal syndrome.

Anna
stopped treatment

The doctor diagnosed her with generalized anxiety disorder and prescribed Paxil. I drank 1/4 of the tablet, after a couple of hours there was wild anxiety, a feeling of a lump in my throat and nausea. Fell asleep. Waking up, I felt like a vegetable: nothing irritates, does not please, all emotions are so muffled that they seem to be non-existent. She did not take the drug anymore.

Infestor
transformed

Suffered from anxiety-panic disorder, took escitalopram for about two years.

There was a feeling that the drug dulled the senses: because of it, I really felt like I didn’t give a damn. I came to the conclusion that during therapy it is better not to build a relationship with a person who is not in the subject, because it is difficult to show emotions. It seems that the partner is sexually attracted, you enjoy spending time with him, but you cannot fully express your feelings.

After treatment, the situation returned to normal. Now I feel great, I lead an active lifestyle, I go in for sports intensively. He became more collected in work and, in general, seemed to be born again.

Side effect No. 2

Weight gain

Kutro
worried about being overweight

I have been taking the antidepressant paroxetine along with the neuroleptic thioridazine for about six months. It helps well, but there is a side effect: I gained a lot of extra pounds. I have been thin all my life, and now I feel uncomfortable at the new weight.

Side effect No. 3

Decreased libido

Wintermute
already normal

I took Velaxin. At the beginning of the reception, I felt sick and had a stomach ache, as if an ulcer was exacerbated. But that’s okay. The main side effect is completely cut off libido and sensitivity. That you stroke your knee, that intimate places – everything is one. After the drug was discontinued, everything returned to normal, but it was scary.

Stefano
continues treatment

For nine months he took the antidepressant “Cipralex” along with the tranquilizer “Atarax”. Thanks to the treatment, he returned to normal life. Of the side effects were unusual dreams, decreased libido and difficulty achieving orgasm.

After moving to another country, he turned to a new psychiatrist, who decided to replace Cipralex with Zoloft. From the last libido decreased even more, sexual intercourse became very long. After discontinuation of the drug, the negative effects persisted. As a result, I returned to Cipralex, I hope everything will be restored with time.

8 myths on antidepressants

Side effect No. 4

diarrhea

Flame
took SioSC

Goloft. The first two weeks I had diarrhea, then everything went away. There were also difficulties in achieving orgasm, while libido remained normal.

Green-eyed
experienced only one side effect

Was treated with Cipralex for a year. The first five days there was loose stools, there were no more side effects. The mood improved, anxiety and irritability disappeared.

12 important questions to psychiatrist Kirill Sychev

Side effect No. 5

Problems with sleep

Aliya Abdullina
did not sleep well

When I took and duloxetine, there were problems with sleep. She fell asleep normally, but after four or five hours she woke up and then slept fitfully, restlessly, after waking up she did not feel rested. Even during the day, the brain seemed to turn off, my limbs twitched, as if in a fast phase of sleep.

The doctor changed the regimen of taking the drug, it got better, but I still can’t sleep during the day, even if I really want to. As soon as I fall into a dream, I immediately wake up.

10 things to know before taking antidepressants

Everything else is fine. Weight and appetite did not change during therapy. Libido decreased, but quickly recovered. At the very beginning of the treatment, there was a lump in the throat, which was rather unpleasant, but this did not last long – five days.

user1331271
had unpleasant dreams

While on antidepressants, she suffered from nightmares and sometimes had very strange vivid dreams. The side effects were fully manifested when the doctor changed the dosage.

burnet
slept for two days

Suffered from insomnia and eating problems. The doctor diagnosed an anxiety-depressive disorder and prescribed mirtazapine.

I did not notice any changes in my mental state. My appetite didn’t wake up, sleep problems generally worsened: I took medicine before going to bed, and then lay half the night looking at the ceiling. Waking up in the morning was a hell of a lot, just like sitting through working hours in the office. But by the evening, I magically became cheerful. This was repeated from day to day.

I don’t remember how long I abused myself by continuing to take the drug. But I remember that once I came home on Friday, sat down on the sofa and woke up on Sunday evening, and a little later fell asleep again until Monday.

Throughout the therapy it seemed that I did not exist: I either sleep, or I try to sleep, or, on the contrary, I struggle with sleep.

Side effect no. 6

Thirst and swelling

Beauty master
no longer panics

I drank the antidepressant “Serenata” and an antipsychotic. I suffered from terrible thirst. She got up several times during the night to drink, and by morning she was swollen like a beekeeper who fell asleep face down in a hive.

For the first two weeks of therapy, the head was like in a fog, then it went away. I gained six or seven kilograms in weight. But thanks to the treatment, her mental state returned to normal: she began to sleep better, learned to control panic.

Coping with a panic attack: advice from a psychotherapist

Side effect No. 7

Nausea

Daria
was not very worried about side effects

The doctor prescribed Serenata because of sleep problems: I didn’t sleep much, and if I fell asleep, I had nightmares. Of the side effects, there was a slight nausea, but it did not bother me much and passed after a couple of weeks. On the second day of therapy, the face was swollen. I didn’t notice anything else that was bad.

Side effect #8

Anxiety

Ninja Turtle
thought about suicide

Took antidepressants three times. The first was Paxil. He was discharged without tranquilizers, so in the very first days of therapy he was seized with wild anxiety, it came to thoughts of suicide. The doctor added a tranquilizer and the anxiety went away. But short-term memory and attention broke down.

As a result, I was transferred to Cipramil. Because of him, libido disappeared, the menstrual cycle flew off and constipation began. At the same time, the mood, as it was below the plinth, remained the same. Six months later, Anafranil was prescribed. Libido recovered, other side effects persisted. But psychologically, I felt much better, even changed jobs during therapy.

What is depression?

Word by word
found the optimal dose of the drug

I took fluvoxamine for six months because of an anxiety-depressive disorder. At the beginning of therapy, anxiety increased markedly for no significant reason. A month later, the dosage of the drug was increased. At first I felt fine, but after three weeks a very unpleasant symptom appeared – tension in the body that I could not control. As a result, the dosage had to be reduced again, after which the state of health returned to normal.

Side effect no. 9

Decreased concentration

Mot
does not complain

Took mirtazapine. It was as if drunk from him. Now I’m taking Cipralex. Distractedness and drowsiness torment from time to time. But these symptoms are nothing compared to what I experienced due to generalized anxiety disorder.

Side effect No. 10

Excessive arousal

Olga Selivanova
experienced a rare side effect

Euphoria was a side effect of my therapy. Against the background of a long-term lowered mood, colors seem to have returned to life: the world has become brighter even visually. I wanted to sing, dance and hug everyone right on the street. The effect lasted about a week, then passed. The doctor said that this is quite rare.

Six months after the treatment, I managed to feel something similar – when you get up in the morning, and you are in a good mood and have strength, and by default you feel somehow calm and good.

How to choose a psychotherapist

Have you had or have a disease that has affected your lifestyle or attitude? Share your story and be the hero of new material

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Escitalopram: Pediatric Medication | Memorial Sloan Kettering Cancer Center

Pediatric Medicine

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This document provided by Lexicomp ^® contains all the information you need to know about the drug, including indications, directions for use, side effects, and when you should contact your healthcare provider.

Trade names: USA

Lexapro

Trade names: Canada

ACH-Escitalopram; ACT Escitalopram ODT; AG-Escitalopram; APO Escitalopram; Auro Escitalopram; BIO-Escitalopram; Cipralex; KYE-Escitalopram; M-Escitalopram; Mar-Escitalopram; MINT-Escitalopram; MYLAN-Escitalopram; NAT-Escitalopram; NRA-Escitalopram; PMS-Escitalopram; PMSC-Escitalopram; RIVA Escitalopram; SANDOZ Escitalopram; TARO-Escitalopram; TEVA-Escitalopram

Warning

• Drugs like this have increased the likelihood of suicidal thoughts or actions in children and young people. This risk may be higher in people who have tried or had suicidal thoughts in the past. All people taking this drug must be closely monitored. If you develop or worsen disorders such as depression, nervousness, anxiety, grouchiness, panic attacks, and changes in mood or behavior, contact your doctor immediately. Contact your doctor immediately if you have suicidal thoughts or suicide attempts.
• This drug is not approved for use in children of all ages. Check with your doctor to make sure this drug is right for your child.

What is this drug used for?

• Used to treat depression.
• Used to treat anxiety.
• This drug can be given to children for other indications. Consult your doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

• If your child has an allergy to this drug, any of its ingredients, other drugs, foods, or substances. Tell the doctor about the allergy and how it manifested itself in the child.
• If the child is receiving any of the following drugs: linezolid or methylene blue.
• If your child is taking any of these drugs: citalopram or pimozide.
• If your child has taken medications for depression or certain other illnesses in the last 14 days. These include isocarboxazid, phenelzine, and tranylcypromine. An episode of very high blood pressure may occur.

This list of drugs and conditions that may interact unfavorably with this drug is not exhaustive.

Talk to your doctor or pharmacist about all medicines your child is taking (prescription and over-the-counter, natural, and vitamins) and any health problems. You need to make sure that this drug is safe to use for your child’s illnesses and in combination with other drugs he or she is already taking. Do not start, stop taking, or change the dosage of any drug your child is taking without the doctor’s approval.

What do I need to know or do while my child is taking this drug?

• Tell all health care providers who care for your child that your child is taking this drug. These are your child’s doctors, nurses, pharmacists and dentists.
• Have your child avoid tasks or activities that require attention until you see how this drug works for your child. This includes cycling, playing sports, or using items such as scissors, lawn mowers, electric scooters, toy cars, or motorized vehicles.
• Do not stop giving this drug to your child abruptly without talking to the doctor. This can increase your child’s risk of side effects. If needed, this drug should be stopped gradually for your child as directed by the doctor.
• Alcohol can interact with this drug. Make sure your child does not drink alcohol.
• Check with your child’s doctor before using marijuana, other forms of cannabis, or prescription or over-the-counter drugs that may slow your child’s progress.
• Depression may improve sleep and appetite quickly after starting this drug. It may take up to 4 weeks to relieve other symptoms of depression.
• This drug may increase the risk of bleeding. Sometimes bleeding can be life-threatening. Consult your doctor.
• This drug may cause low sodium levels. Very low sodium levels can be life-threatening, leading to convulsions, fainting, difficulty breathing, or death.
• In some cases, the drug may affect the growth rate in children and adolescents. They may need regular growth rate checks. Consult your doctor.

If your daughter is pregnant or breastfeeding:

• Consult physician if your daughter is pregnant, pregnant, or breastfeeding. The benefits and risks for your daughter and her baby will need to be discussed.
• Taking this drug during the third trimester of pregnancy may cause some health problems in the newborn. Consult your doctor.

What side effects should I report to my child’s doctor right away?

WARNING/CAUTION: Although rare, some people may have very serious and sometimes deadly side effects of this drug. Call your child’s doctor right away or seek medical attention if your child has any of the following signs or symptoms that could be associated with a very bad side effect:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confused thinking, weakness, seizures, problems with balance.
• signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
• Seizures.
• Fever or chills.
• Painful erections or erections that last more than 4 hours.
• Some patients may be at increased risk of eye problems when using this drug. Your child’s doctor may schedule an eye exam to see if your child is at increased risk for these eye problems. Call your doctor right away if your child has eye pain, vision changes, swelling, or redness around the eye.
• A severe and sometimes deadly complication called serotonin syndrome can occur. This risk may be increased if the child is also taking certain other drugs. Call your child’s healthcare provider right away if your child has agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythm, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting, a very severe headache.

If your child is or may be sexually active:

• Against the background of taking such drugs, violations of sexual function were noted. These included decreased interest in sex, problems achieving orgasm, problems ejaculating, or problems getting or maintaining an erection. If you have any questions, please consult your doctor.

What are some other side effects of this drug?

Any drug can have side effects. However, for many people, side effects are either minor or non-existent. Contact your child’s doctor or seek medical attention if any of these or other side effects bother your child or if they persist:

• Feeling dizzy, drowsy, tired or weak.
• Headache.
• Nausea.
• Sleep disorders.
• Dry mouth.
• Diarrhea or constipation.
• Excessive sweating.
• Flu-like symptoms.
• Runny nose.
• Yawn.

This list of possible side effects is not exhaustive. If you have any questions about side effects, ask your child’s doctor. Talk to your child’s doctor about side effects.

You can report side effects to the National Health Board.

What is the best way to give this drug?

Give this drug to your child as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All forms:

• Give this drug with or without food.
• Keep giving this drug as directed by your child’s doctor or other health care provider, even if your child is feeling well.

Oral solution:

• Liquid doses should be measured with caution. Use the dispenser that comes with the medicine. If the dispenser is not provided in the package, ask the pharmacist for a dosing agent for this drug.

What if my child misses a dose of medication?

• Give the missed dose as soon as possible.
• If it is time for your child to take the next dose, do not take the missed dose and then go back to your child’s normal schedule.
• Do not give a double dose at the same time or additional doses.

How do I store and/or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General drug information

• If your child’s symptoms or health problems do not improve, or worsen, contact your child’s doctor.
• Do not share your child’s medicine with others and do not give anyone else’s medicine to your child.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your child’s doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes summaries of diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances.