Side effects of esomeprazole – NHS

Most people who take esomeprazole do not have any side effects. If you do get a side effect, it is usually mild and will go away when you stop taking esomeprazole.

Common side effects

These common side effects of esomeprazole happen in more than 1 in 100 people. There are things you can do to help cope with them:

Headaches

Make sure you rest and drink plenty of fluids. It’s best not to drink too much alcohol. Headaches usually go away after the first week, but ask your pharmacist to recommend a painkiller, or talk to your doctor if they last more than a week or are severe.

Feeling sick

Try taking esomeprazole with or after a meal or snack. It may also help if you do not eat rich or spicy food while you’re taking this medicine. Try drinking small, frequent sips of water to avoid dehydration.

Being sick

Take, small, frequent sips of water to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee.

If you take contraceptive pills and you’re being sick your contraception may not protect you from pregnancy. Check the pill packet for advice.

Diarrhoea

Drink plenty of fluids, such as water or squash, to prevent dehydration. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee.

If the diarrhoea does not get better, talk to your doctor.

If you take contraceptive pills and you have diarrhoea, your contraception may not protect you from pregnancy. Check the pill packet for advice.

Constipation

Get more fibre into your diet such as fresh fruit and vegetables and cereals, and drink plenty of water. Try to exercise regularly, for example, by going for a daily walk or run. If this does not help, talk to your pharmacist or doctor.

Stomach pain

Try to rest and relax. It can help to eat and drink slowly and have smaller and more frequent meals. Putting a heat pad or covered hot water bottle on your stomach may also help. If you are in a lot of pain, speak to your pharmacist or doctor.

Farting (flatulence)

Try to avoid foods that cause farting, like pulses, lentils, beans and onions. It might help to eat smaller meals more frequently, eat and drink slowly, and exercise regularly. Some pharmacy remedies, such as simeticone, may improve the problem.

Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.

Serious side effects

Serious side effects happen in less than 1 in 1,000 people.

Call a doctor or contact 111 if:

• your skin becomes yellow (although this may be less obvious on brown or black skin), your pee becomes darker and you feel more tired – these can be signs of liver problems
• you get joint pain along with a red skin rash, especially on parts of your body exposed to the sun, such as your arms, cheeks and nose – these can be signs of a rare condition called subacute cutaneous lupus erythematosus. This can happen even if you have been taking esomeprazole for a long time
• you have diarrhoea that is severe or does not go away – this can be a sign of an inflamed bowel

Go to 111.nhs.uk or call 111.

Serious allergic reaction

In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to esomeprazole.

Immediate action required: Call 999 or go to A&E now if:

• you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
• you’re wheezing
• you get tightness in the chest or throat
• you have trouble breathing or talking
• your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

Long term side effects

If you take esomeprazole for more than 3 months, the levels of magnesium in your blood may fall.

Low magnesium can make you feel tired, confused, dizzy and cause muscle twitches, shakiness and an irregular heartbeat. If you get any of these symptoms, tell your doctor.

Taking esomeprazole for more than a year may increase your chances of certain side effects, including:

• bone fractures
• gut infections
• vitamin B12 deficiency – symptoms include feeling very tired, a sore and red tongue, mouth ulcers and pins and needles

If you take esomeprazole for longer than 1 year, your doctor will regularly check your health to see if you should carry on taking it.

It’s not known if esomeprazole works less well the longer you take it. If you feel like it is not working any more, talk to your doctor.

Other side effects

These are not all the side effects of esomeprazole. For a full list, see the leaflet inside your medicine packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

Page last reviewed: 7 January 2022

Next review due: 7 January 2025

Esomeprazole: Uses, Interactions, Mechanism of Action

Kit	Oral; Topical
Injection, powder, lyophilized, for solution	Intravenous
Tablet, film coated
Tablet, coated	Oral	20 mg
Tablet, delayed release	Oral
Injection, powder, for solution
Capsule, delayed release pellets	Oral
Powder	Intravenous	40 mg/1vial
Powder	Intravenous	40 mg
Powder, for solution	Intravenous	40 mg
Injection	Intravenous	40 mg
Capsule, delayed release	Oral	22. 25 MG
Capsule, delayed release	Oral	44.5 MG
Injection, powder, for solution		40 mg
Tablet, delayed release	Oral	22.545 MG
Tablet, delayed release	Oral	45.09 MG
Capsule, coated pellets	Oral	20 mg
Capsule, coated pellets	Oral	40 mg
Granule	Oral	5 mg
Capsule, delayed release	Oral	20 MG
Tablet, delayed release	Oral	20 mg
Tablet, delayed release	Oral	40 mg
Injection, powder, for solution	Parenteral
Capsule, delayed release	Oral
Capsule	Oral	20 mg/1
Tablet, delayed release	Oral	20 mg/1
Capsule, coated pellets	Oral	20 mg/1
Capsule, coated pellets	Oral	40 mg/1
Capsule, delayed release	Oral	40 1/1
Capsule, delayed release pellets	Oral	20 mg/1
Capsule, delayed release pellets	Oral	40 mg/1
For suspension	Oral	20 mg/1
For suspension	Oral	40 mg/1
Granule, for suspension, extended release	Oral	10 mg/1
Injection, powder, for solution	Intravenous	40 mg
Injection	Intravenous	40 mg/5mL
Injection, powder, for solution	Intravenous
Injection, powder, for solution; injection, powder, lyophilized, for solution	Intravenous	40 mg
Injection, powder, lyophilized, for solution	Intravenous	20 mg/1
Injection, powder, lyophilized, for solution	Intravenous	20 mg/5mL
Injection, powder, lyophilized, for solution	Intravenous	40 mg/5mL
Injection, powder, lyophilized, for solution	Intravenous	40 mg/1
Capsule, delayed release	Oral	24. 65 mg/1
Capsule, delayed release	Oral	49.3 mg/1
Capsule	Oral	20 MG
Capsule	Oral	40 MG
Tablet	Oral	40 MG
Powder, for solution	Parenteral	40 MG
Capsule, coated	Oral	20 mg
Capsule	Oral
Powder	Oral
Injection, powder, lyophilized, for solution	Intravenous	40 mg
Tablet	Oral
Tablet, coated	Oral	20.00 mg
Tablet, coated	Oral	40.00 mg
Tablet, film coated	Oral	20 mg
Tablet, coated	Oral	40 mg
Capsule, coated	Oral	41.2 mg
Capsule, coated	Oral	40 mg
Granule	Oral	10 MG
Injection, powder, for solution	Parenteral	40 MG
Tablet, coated	Oral
Tablet, film coated	Oral
Granule	Oral	2. 5 mg
Granule	Oral	0.167 g
Granule	Oral	20 mg
Granule	Oral	40 mg
Capsule, delayed release	Oral	20 mg/1
Capsule, delayed release	Oral	40 mg/1
Granule, delayed release	Oral	10 mg/1
Granule, delayed release	Oral	10 mg / sachet
Granule, delayed release	Oral	2.5 mg/1
Granule, delayed release	Oral	20 mg/1
Granule, delayed release	Oral	40 mg/1
Granule, delayed release	Oral	5 mg/1
Tablet, film coated	Oral	40 mg
Granule, delayed release	Oral
Granule, delayed release	Oral	10 MG
Tablet	Oral	20 mg/1
Tablet	Oral	20 MG
Injection	Intravenous	20 mg/5mL
Tablet, film coated	Oral
Tablet, coated	Oral	20 mg
Capsule, extended release	Oral	40 mg
Kit	Oral	20 mg/1
Capsule, delayed release	Oral	40 mg
Injection, powder, lyophilized, for solution	Intravenous	42. 5 mg
Tablet, coated	Oral	44.55 mg
Capsule, coated	Oral
Tablet, delayed release	Oral	22545 Mg
Injection, powder, for solution	Intravenous	40.00 mg
Injection	Intravenous
Tablet	Oral
Tablet, delayed release	Oral
Tablet, extended release	Oral
Injection, powder, for solution		40 mg/1vial

Memorial Sloan Kettering Cancer Center

Adult Medication

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Provided by Lexicomp ^® , this document contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Esomep-EZS [DSC]; NexIUM; NexIUM 24HR Clear Minis [OTC]; NexIUM 24HR [OTC]; NexIUM I. V.

Trade names: Canada

APO-Esomeprazole; M-Esomeprazole; MYL-Esomeprazole; MYLAN-Esomeprazole [DSC]; NexIUM; PMS-Esomeprazole DR; PMSC-Esomeprazole DR; SANDOZ Esomeprazole; TARO-Esomeprazole; TEVA-Esomeprazole

What is this drug used for?

• Used to treat gastroesophageal reflux disease (GERD; acid reflux).
• Used to treat heartburn.
• It is used to treat and prevent ulcers of the gastrointestinal tract caused by infection.
• It is used for the treatment and prevention of esophageal ulcers.
• It is used to treat symptoms caused by excessive stomach acid in the body.
• It is used to treat and prevent gastrointestinal ulcers while taking non-steroidal anti-inflammatory drugs (NSAIDs) in patients with a history of ulcers. Examples of NSAIDs include ibuprofen and naproxen.
• It is used to reduce the risk of bleeding ulcers after a certain procedure (endoscopy).
• This drug may also be used for other indications. Consult your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you are taking any of these medicines: atazanavir, clopidogrel, nelfinavir, rifampin, rilpivirine, or St. John’s wort.
• If you have any of the following health conditions: black or bloody stools; heartburn with dizziness, sweating, dizziness, or wheezing; chest pain; shoulder pain with shortness of breath; pain that radiates to the arm, neck, or shoulders; dizziness; excessive sweating; vomiting blood; difficulty or pain when swallowing food.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (both prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Do not take this drug for longer than the length of time your doctor has prescribed.
• This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
• In people with fragile bones (osteoporosis), this drug increases the chance of hip, spine, and wrist fractures. This chance may be higher if you have been taking this drug at high doses or for longer than one year, or if you are over 50 years of age.
• Be careful if you are at risk of developing a condition in which bones become brittle and soft (osteoporosis). These risks may include drinking alcohol, smoking, taking steroids, taking anticonvulsants, or having family members with osteoporosis. Talk to your doctor about your risk of developing osteoporosis.
• Rarely, people who have taken medications like this for 3 months or more have had low magnesium levels. In most cases, this effect developed after 1 year of treatment. Decreased magnesium levels can lead to other electrolyte disturbances. You may need to take a blood test as directed by your doctor.
• Long-term (e.g. more than 3 years) treatment with drugs like this has in rare cases led to a decrease in vitamin B12 levels. If you develop symptoms of vitamin B12 deficiency such as shortness of breath, dizziness, irregular heartbeat, muscle weakness, pale skin, fatigue, mood changes, numbness or tingling in your hands or feet, contact your healthcare provider right away.
• There have been cases of lupus and worsening of pre-existing lupus with this drug. If you have lupus, tell your doctor. If you develop signs of lupus, such as a rash on the cheeks or other parts of the body, changes in skin color, rapid onset of sunburn, muscle or joint pain, chest pain, shortness of breath, swelling of the arms or legs, seek immediate medical attention.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Call your doctor or seek medical help right away if you have any of the following signs or symptoms that may be associated with serious side effects:

All formulations:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of electrolyte disturbances such as mood swings, confusion, muscle pain, cramps or spasms, weakness, tremors, balance problems, arrhythmias, seizures, loss of appetite, and severe nausea or vomiting.
• Signs of kidney problems, including not passing urine, changes in the volume of urine, blood in the urine, or rapid weight gain.
• Severe dizziness or fainting.
• Bone pain.
• Significant weight loss.
• This drug may increase the risk of developing a severe form of diarrhea called Clostridium difficile (C. diff.) [CDAD]. Call your doctor right away if you have pain or cramps in your stomach or very thin, watery, or bloody stools. Do not try to treat diarrhea on your own without first talking to your doctor.
• Against the background of the use of this drug, severe reactions from the skin are possible. These include Stevens-Johnson syndrome (SSD), toxic epidermal necrolysis (TEN), and other serious skin reactions. Sometimes internal organs can also be affected. Such reactions can lead to death. Seek immediate medical attention if you experience skin symptoms such as redness, swelling, blisters, or peeling; with redness or irritation of the eyes; sores in the mouth, throat, nose, eyes or genitals, or any other area of ​​the skin; with high fever, chills, body pain, shortness of breath, or swollen lymph nodes.

Injection:

• Irritation at the injection site.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Headache.
• Abdominal pain or diarrhea.
• Constipation.
• Gas formation.
• Dry mouth.
• Nausea.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

Tablets:

• The drug should be taken no later than 1 hour before meals with a full glass of water.
• Swallow whole. Do not chew, break or crush.
• Keep taking this drug as instructed by your doctor or other health care professional, even if you feel well.

Capsules:

• The drug should be taken no later than 1 hour before meals with a full glass of water.
• Swallow whole. Don’t chew or crumble.
• Keep taking this drug as instructed by your doctor or other health care professional, even if you feel well.
• If you cannot swallow this drug whole, add the contents of the capsule to applesauce. Then swallow the mixture immediately without chewing.
• If mixed with applesauce, the puree should not be warm. Do not pour into other liquids or food.
• Take the dose immediately after mixing. Do not store for future use.
• Patients with feeding tubes can take the drug in liquid form. Place the contents of the capsule into a 60 ml syringe and add 50 ml of water. Insert the plunger into the syringe and shake it for 15 seconds. Flush the feeding tube before and after taking the drug.

Powder for suspension:

• Take this medication 1 hour before meals.
• Mix contents of 2.5 mg or 5 mg packets with 1 teaspoon (5 ml) of water, or contents of 10 mg, 20 mg or 40 mg packets with 1 tablespoon (15 ml) of water. If 2 packets are required, follow these steps by adding twice as much water. Stir in water, then leave for 2-3 minutes. Mix and drink.
• Take your dose within 30 minutes of mixing the drug. Throw away any servings not used within 30 minutes of mixing.
• Add more water and drink the rest.
• Keep taking this drug as instructed by your doctor or other health care professional, even if you feel well.
• This drug can also be used by patients with artificial feeding tubes. For 2.5 mg or 5 mg packets, add 5 ml of water to the syringe, then add the contents of the packet to the syringe. For 10 mg, 20 mg, or 40 mg packets, add 15 ml of water to the syringe, then add the contents of the packet to the syringe. Insert plunger and shake. Leave on for 2-3 minutes. Shake again and pass through a feeding tube. After taking this drug, refill the syringe with the same amount of water, shake, and rinse the feeding tube.

Injection:

• This drug is administered by injection intravenously or intravenously continuously for a certain time.

What if I miss a dose of a drug?

All oral preparations:

• Take the missed dose as soon as you can.
• If it’s time for your next dose, don’t take the missed dose and then go back to your regular dosing schedule.
• Do not take 2 doses or an additional dose at the same time.

Injection:

• See your doctor for further instructions.

How do I store and/or discard this drug?

All oral preparations:

• Store at room temperature in a dry place. Do not store in the bathroom.

Tablets and capsules:

• The lid must be tightly closed.

Injection:

• If you need to store this drug at home, check with your doctor, nurse, or pharmacist for storage conditions.

All forms:

• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www. wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2022-03-23 ​​

Copyright

© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

Active substance ESOMEPRAZOLE (ESOMEPRAZOLUM) | Compendium – drug reference book

• Pharmacological properties
• Indications Esomeprazole
• Application of Esomeprazole
• Contraindications
• Side effects
• Special instructions
• Interactions
• Overdose
• Diagnosis
• Recommended alternatives

No. 1

Prices in pharmacies

Esom

lyophilisate for solution for infusion and injection 40 mg vial, No. 1

Hetero Labs Limited

Pharmacy prices

Pharmacy prices

Nexium tablets

film-coated tablets 20 mg blister No. 14

Prices in pharmacies ah

Nexpro-40

enteric-coated tablets 40 mg blister, № 14

Torrent

Prices in pharmacies ster, № 14

SUN

Pharmacy prices

Pemozar

gastroresistant tablets 40 mg blister, № 14

SUN

Prices in pharmacies0003

SUN

Prices in pharmacies

Pompezo

powder for solution for injection 40 mg vial, № 1

World Medicine

Prices in pharmacies

Ezolong®

powder for solution for injection or infusion 40 mg vial, No. 10

Organosyn Life Sciences

Prices in pharmacies

Ezolong ^® -20

film-coated tablets 20 mg blister in a box, No. 14

Organosyn Life Sciences

Prices in pharmacies

Ezolong ^® -40

film-coated tablets 40 mg blister in box No. 14

Organosyn Life Sciences

Prices in pharmacies 9000 3

Esomeprazole

lyophilisate for solution for infusion or injection 40 mg vial, № 1

Zdorovye Group of companies

Prices in pharmacies

Esomer

gastroresistant tablets 40 mg blister, № 28

Perrery Farmaceutici SRL

Prices in pharmacies

Esonexa ^®

enteric tablets 20 mg blister, № 14

Farmak

Prices in pharmacies

Esonex a ^®

enteric tablets 40 mg blister no. 14

Prices in pharmacies

Ezoprotect

Lyophilisate for solution for infusion and injection 40 mg vial, no. 1

Mistral Capital Management

Pharmacy prices

Ezorma

powder for solution for injection or infusion 40 mg vial, no. 1

Macleods Pharmaceuticals Ltd

Prices in pharmacies

Emanera

enteric capsules 20 mg blister, № 14, 28

KRKA d.d. Novo Mesto

Prices in pharmacies

Emanera

enteric capsules 40 mg blister, № 28

KRKA d.d. Novo Mesto

Prices in pharmacies

Esozol

lyophilisate for solution for infusions or injections 40 mg vial, № 1

Scan Biotech

Prices in pharmacies

ezome prazol is the S-isomer of omeprazole, which reduces the secretion of gastric juice due to its specific directed mechanism of action. It is an inhibitor of the proton pump of the parietal cells of the gastric mucosa. R- and S-isomers of omeprazole have the same pharmacodynamic activity.

Esomeprazole is a weak base, it is concentrated and converted into an active form in the acidic environment of the secretory tubules of parietal cells, where it inhibits the enzyme H ⁺ K ⁺ -ATPase – a proton pump, and also inhibits basal and stimulated acid secretion.

gastroesophageal reflux disease (GERD): treatment of erosive reflux esophagitis; long-term anti-relapse therapy for reflux esophagitis in cured patients; symptomatic treatment of GERD.

In combination with antibacterial agents for the eradication of Helicobacter pylori: treatment of duodenal ulcer associated with Helicobacter pylori ; prevention of peptic ulcer recurrence in patients with ulcers associated with Helicobacter pylori .

Treatment and prevention of ulcerative processes associated with long-term use of NSAIDs: treatment of ulcerative processes associated with NSAID therapy; prevention of the development of gastric and duodenal ulcers in patients at risk due to the use of NSAIDs.

Treatment of Zollinger-Ellison syndrome. Esomeprazole tablets are used to maintain hemostasis and prevent the development of rebleeding from a gastric or duodenal ulcer after therapy with esomeprazole solution for infusion.

20–40 mg once daily. Powder for the preparation of solution for injection and infusion is indicated for antisecretory therapy, in cases where the oral route of administration is not possible.

for parenteral use – children under 18 years of age, for oral use – children under 12 years of age.

from the blood and lymphatic system: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.

From the immune system: hypersensitivity reactions (fever, angioedema and anaphylactic reaction / shock).

From the side of metabolism: peripheral edema, hyponatremia, hypomagnesemia.

Mental disorders: insomnia, agitation, depression, confusion, aggression, hallucinations.

From the side of the central nervous system: headache, dizziness, paresthesia, drowsiness, taste disturbance.

On the part of the organ of vision: blurred vision.

On the part of the organ of hearing: vestibular dizziness.

From the respiratory system: bronchospasm.

From the digestive system: abdominal pain, constipation, diarrhea, bloating, nausea, vomiting, dry mouth, stomatitis, candidiasis of the digestive tract.

From the hepatobiliary system: increased activity of liver enzymes, hepatitis with and without jaundice, liver failure, encephalopathy in patients with liver disease.

From the skin and soft tissues: reactions at the injection site, dermatitis, itching, rash, urticaria, alopecia, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

From the musculoskeletal system: arthralgia, myalgia, muscle weakness.

From the side of the kidneys and urinary system: interstitial nephritis.

From the reproductive system: gynecomastia.

General disorders: weakness, excessive sweating.

patients taking esomeprazole for a long period (especially >1 year) should be under regular medical supervision.

Effect of esomeprazole on the pharmacokinetics of other medicinal products. Decreased gastric acidity during treatment with esomeprazole may lead to an increase or decrease in the absorption of other drugs, the mechanism of absorption of which depends on the acidity of gastric juice. As with other acid secretion inhibitors or antacids, treatment with esomeprazole results in decreased absorption of ketoconazole and itraconazole during treatment with esomeprazole.

Esomeprazole inhibits CYP 2C19, the main enzyme that metabolizes esomeprazole. Therefore, the use of esomeprazole in combination with drugs metabolized by CYP 2C19(diazepam, cytolopram, imipramine, clomipramine, phenytoin) may lead to an increase in the concentration of these drugs in the blood plasma and require a reduction in their dose.