What are the uses of esterified estrogens and methyltestosterone. How should this medication be taken. What are the potential side effects and risks associated with this hormone therapy.

Understanding Esterified Estrogens and Methyltestosterone

Esterified estrogens and methyltestosterone is a combination medication used primarily for the short-term treatment of menopausal symptoms. This hormone therapy consists of two key components: a female hormone (estrogen) and a male hormone (methyltestosterone). The medication is designed to address the hormonal imbalance that occurs when a woman’s body reduces its natural production of estrogen during menopause.

Key Components of the Medication

• Esterified estrogens: A form of estrogen hormone
• Methyltestosterone: A synthetic form of testosterone

The combination of these hormones works synergistically to alleviate various menopausal symptoms, providing relief to women experiencing discomfort during this transitional phase of life.

Primary Uses and Benefits of Est Estrogen Methyl Test

The primary purpose of this medication is to manage the uncomfortable symptoms associated with menopause. These symptoms can significantly impact a woman’s quality of life, and hormone replacement therapy aims to mitigate these effects.

Common Menopausal Symptoms Addressed

• Hot flashes: Sudden feelings of heat in the upper body and face
• Night sweats: Excessive sweating during sleep
• Vaginal dryness: Discomfort and itching in the vaginal area
• Vaginal atrophy: Thinning and inflammation of vaginal walls

By targeting these symptoms, esterified estrogens and methyltestosterone can help women navigate the menopausal transition more comfortably. However, it’s crucial to note that this medication is typically prescribed for short-term use and should be taken under close medical supervision.

Proper Administration and Dosage Guidelines

Correct administration of esterified estrogens and methyltestosterone is crucial for achieving optimal results while minimizing potential risks. The medication is typically taken orally, following a specific dosing schedule prescribed by a healthcare provider.

Typical Dosing Schedule

1. Take one tablet daily for 21 consecutive days
2. Follow with a 7-day break (no medication)
3. Repeat the cycle as directed by your doctor

Is it necessary to take the medication with food? While it can be taken with or without food, some women find that taking it with a meal or immediately after eating helps prevent stomach upset. Consistency in timing is important, so it’s advisable to take the medication at the same time each day.

How long should this medication be used? Healthcare providers typically recommend using this hormone therapy for the shortest duration possible to achieve symptom relief. Regular check-ups (every 3 to 6 months) are essential to evaluate the ongoing need for treatment and adjust the dosage if necessary.

Potential Side Effects and Risks

While esterified estrogens and methyltestosterone can provide significant relief from menopausal symptoms, it’s important to be aware of potential side effects and risks associated with this hormone therapy.

Common Side Effects

• Nausea and vomiting
• Headaches
• Breast tenderness
• Fluid retention
• Changes in menstrual flow

These side effects are generally mild and may subside as your body adjusts to the medication. However, if they persist or worsen, it’s important to consult your healthcare provider.

Serious Risks and Complications

Long-term use of hormone therapy, particularly estrogen-containing medications, has been associated with several serious health risks. These include:

• Increased risk of breast and ovarian cancer
• Higher likelihood of developing endometrial cancer (if taken without a progestin)
• Elevated risk of stroke and blood clots
• Potential increase in heart disease risk
• Possible link to dementia in older women

Do these risks apply to all women taking hormone therapy? The level of risk can vary depending on factors such as age, personal and family medical history, and duration of use. It’s crucial to discuss your individual risk profile with your healthcare provider before starting this medication.

Precautions and Contraindications

Given the potential risks associated with esterified estrogens and methyltestosterone, certain precautions should be observed, and some individuals may not be suitable candidates for this therapy.

Who Should Avoid This Medication?

• Women with a history of breast or uterine cancer
• Those with a history of blood clots or stroke
• Individuals with liver disease or impaired liver function
• Women who are pregnant or may become pregnant
• Those with undiagnosed vaginal bleeding

Is a thorough medical evaluation necessary before starting this medication? Absolutely. Your healthcare provider should conduct a comprehensive assessment of your medical history, current health status, and risk factors before prescribing esterified estrogens and methyltestosterone.

Monitoring and Follow-up

Regular monitoring is essential for women taking this hormone therapy. This typically includes:

• Annual physical examinations
• Breast cancer screenings
• Pelvic exams and Pap smears
• Periodic blood tests to check hormone levels and liver function

These check-ups allow healthcare providers to assess the ongoing benefits and risks of the therapy and make necessary adjustments to the treatment plan.

Interactions with Other Medications and Substances

Esterified estrogens and methyltestosterone can interact with various medications and substances, potentially altering their effectiveness or increasing the risk of side effects.

Common Drug Interactions

• Blood thinners (e.g., warfarin)
• Thyroid medications
• Certain antibiotics
• Anti-seizure medications
• St. John’s Wort (herbal supplement)

Should you inform your healthcare provider about all medications and supplements you’re taking? Yes, it’s crucial to provide a comprehensive list of all prescription drugs, over-the-counter medications, vitamins, and herbal supplements you use. This information helps prevent potential drug interactions and ensures the safe use of esterified estrogens and methyltestosterone.

Lifestyle Considerations

Certain lifestyle factors can also impact the effectiveness and safety of this hormone therapy:

• Smoking: Can increase the risk of blood clots and cardiovascular complications
• Alcohol consumption: May affect how the liver processes the medication
• Diet: Grapefruit and grapefruit juice can interact with estrogen metabolism

Discussing these factors with your healthcare provider can help optimize your treatment plan and minimize potential risks.

Alternatives to Esterified Estrogens and Methyltestosterone

While esterified estrogens and methyltestosterone can be effective for managing menopausal symptoms, it’s not the only option available. Depending on individual needs and risk factors, healthcare providers may recommend alternative treatments.

Other Hormone Therapy Options

• Estrogen-only therapy (for women who have had a hysterectomy)
• Estrogen plus progestin therapy
• Low-dose vaginal estrogen preparations
• Bioidentical hormone therapy

Are there non-hormonal alternatives for managing menopausal symptoms? Yes, several non-hormonal options can help alleviate menopausal discomfort:

• Selective serotonin reuptake inhibitors (SSRIs) for hot flashes
• Gabapentin or other anticonvulsants for night sweats
• Over-the-counter vaginal moisturizers and lubricants
• Lifestyle modifications (e.g., diet changes, regular exercise, stress reduction techniques)

The choice of treatment should be based on individual symptoms, health status, personal preferences, and risk factors. A thorough discussion with a healthcare provider can help determine the most appropriate approach for managing menopausal symptoms.

Long-term Considerations and Future Research

As our understanding of hormone therapy continues to evolve, ongoing research aims to clarify the long-term effects and optimize treatment strategies for menopausal symptoms.

Current Areas of Research

• Identifying biomarkers to predict individual response to hormone therapy
• Developing more targeted hormone therapies with fewer side effects
• Investigating the potential cognitive benefits of hormone therapy in certain populations
• Examining the long-term cardiovascular effects of different hormone therapy regimens

How might future research impact the use of esterified estrogens and methyltestosterone? As new data emerges, treatment guidelines may be refined to better balance the benefits and risks of hormone therapy. This could lead to more personalized approaches to managing menopausal symptoms, taking into account individual genetic profiles, health histories, and risk factors.

The Importance of Ongoing Dialogue

Given the complex nature of hormone therapy and its potential long-term effects, maintaining an open dialogue with healthcare providers is crucial. Regular check-ups and discussions about new research findings can help ensure that treatment decisions remain aligned with the most current medical knowledge and individual health needs.

As the field of menopausal health continues to advance, women can look forward to increasingly tailored and effective options for managing the challenges of this life transition. While esterified estrogens and methyltestosterone remain a valuable tool in the management of menopausal symptoms, ongoing research and medical advancements promise to further refine our approach to hormone therapy and women’s health in the years to come.

Esterified Estrogens-Methyltestosterone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Estrogens given alone and with another hormone (progestin) for replacement therapy after menopause have sometimes caused rare but very serious side effects. Discuss the risks and benefits of hormone treatment and your personal health history with your doctor.

Estrogens have been reported to increase the chance of cancer of the uterus (endometrial cancer). Taking a progestin with estrogen decreases this risk. Tell your doctor right away if you have any unusual vaginal bleeding.

In postmenopausal women, estrogens, taken with or without a progestin, increase the risk of cancer of the breast/ovaries, stroke, dementia, and serious blood clots. When used along with a progestin, estrogens also increase the risk of heart disease (such as heart attacks). Some of these risks appear to depend on the length of time this drug is used and the amount of estrogen per dose. This medication should be used for the shortest possible length of time at the lowest effective dose, so you can obtain the benefits and reduce the chance of serious side effects from long-term treatment. Discuss the details with your doctor and check with him/her regularly (such as every 3 to 6 months) to see if you still need to take this medication.

Products that contain estrogen should not be used to prevent heart disease or dementia.

If you use this drug for an extended period, you should have a complete physical exam at regular intervals (such as once a year) or as directed by your doctor. See Notes section.

Warnings:

Estrogens given alone and with another hormone (progestin) for replacement therapy after menopause have sometimes caused rare but very serious side effects. Discuss the risks and benefits of hormone treatment and your personal health history with your doctor.

Estrogens have been reported to increase the chance of cancer of the uterus (endometrial cancer). Taking a progestin with estrogen decreases this risk. Tell your doctor right away if you have any unusual vaginal bleeding.

In postmenopausal women, estrogens, taken with or without a progestin, increase the risk of cancer of the breast/ovaries, stroke, dementia, and serious blood clots. When used along with a progestin, estrogens also increase the risk of heart disease (such as heart attacks). Some of these risks appear to depend on the length of time this drug is used and the amount of estrogen per dose. This medication should be used for the shortest possible length of time at the lowest effective dose, so you can obtain the benefits and reduce the chance of serious side effects from long-term treatment. Discuss the details with your doctor and check with him/her regularly (such as every 3 to 6 months) to see if you still need to take this medication.

Products that contain estrogen should not be used to prevent heart disease or dementia.

If you use this drug for an extended period, you should have a complete physical exam at regular intervals (such as once a year) or as directed by your doctor. See Notes section.

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Uses

This medication is used for the short-term treatment of menopause symptoms. It helps reduce episodes of flushing and sweating of the upper body and face, commonly called hot flashes. It also helps treat dryness, itching, and burning around the vagina. These symptoms occur when a woman’s body no longer produces the usual amount of female hormone (estrogen) at the age when monthly menstrual periods normally stop. This medication is a combination of 2 hormones, a female hormone (estrogen) and a male hormone (methyltestosterone).If you need treatment only for vaginal menopause symptoms, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.

How to use ESTROGEN-METHYLTESTOSTERONE

Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth as directed by your doctor. This medication is usually taken on a cycle, once a day for 21 days followed by no medication for 7 days. Follow your dosing schedule carefully. This drug should be used for the shortest possible length of time. See also Warning section.

This medication may be taken with or without food. You may take it with food or immediately after a meal to prevent stomach upset.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day as directed. Dosage is based on your medical condition and response to therapy.

Inform your doctor if your condition does not improve or worsens.

Side Effects

Dizziness, lightheadedness, headache, stomach upset, bloating, nausea, weight changes, increased/decreased interest in sex, or breast tenderness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn’t stop, mental/mood changes (such as severe depression, memory loss), breast lumps, swelling of hands/feet, unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged/recurrent bleeding), unusual vaginal discharge/itching/odor, changes in skin color, yellowing eyes/skin, unusual tiredness, stomach/abdominal pain, dark urine, worsening of seizures.

Women may experience signs of masculinization (male characteristics) from methyltestosterone. To prevent these changes from becoming permanent, stop taking this medication and tell your doctor right away if any of the following occur: hoarseness, deepening of the voice, facial hair growth, new or worsening acne, an enlarged clitoris, menstrual period changes.

This medication may rarely cause serious problems such as heart attacks, stroke, and blood clots. Get medical help right away if you experience any of the following: chest pain, jaw/left arm pain, sudden severe headache, weakness on one side of the body, confusion, trouble speaking, sudden vision changes (such as double vision, loss of vision), pain/redness/swelling of legs, trouble breathing, coughing up blood, sudden dizziness/fainting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to methyltestosterone or estrogen; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus or ovaries), blood clotting disorders (such as protein C or protein S deficiency), current/history of blood clots (such as in the legs, eyes, lungs), liver problems, family medical history (especially breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), asthma, diabetes, seizures, migraine headaches, heart disease (such as high blood pressure, congestive heart failure, heart attack), stroke, kidney disease, underactive thyroid (hypothyroidism), a certain hormone problem (hypoparathyroidism), mineral imbalance (low or high calcium blood level), mental/mood disorders (such as dementia, depression), high blood pressure during pregnancy (toxemia), yellowing eyes/skin (cholestatic jaundice) during pregnancy or with past estrogen use, uterus problems (such as uterine fibroids, endometriosis), high blood cholesterol/fat (triglyceride) levels, gallbladder disease, obesity, certain blood disorder (porphyria), lupus.

If you have diabetes, this medication may make it harder to control your blood sugar levels. Monitor your blood sugar regularly as directed by your doctor. Tell your doctor the results and of any symptoms such as increased thirst/urination, weakness, or fainting. Your anti-diabetic medication or diet may need to be adjusted.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur.

This medication may cause blotchy, dark areas on your face and skin (melasma). Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

Do not smoke cigarettes or use tobacco. Estrogens combined with smoking further increase your risk for stroke, blood clots, high blood pressure, and heart attacks, especially in women older than 35.

If you will be having surgery or will be confined to a chair or bed for a long time (such as on a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances (such as stopping this medication) because of the increased risk for blood clots. Consult your doctor for details.

This medication is not meant for use in children.

This medication must not be used during pregnancy. It may harm the unborn baby. If you become pregnant or think you may be pregnant, tell your doctor right away.

This medication is not effective for preventing a miscarriage and should not be used for this purpose.

It is unknown if methyltestosterone passes into breast milk. Estrogen passes into breast milk. This medication may harm a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: anastrozole, “blood thinner” (warfarin), corticosteroids (such as prednisone), exemestane, fezolinetant, ospemifene, raloxifene, tamoxifen, tranexamic acid.

Other medications can affect the removal of estrogens from your body, which may affect how this medication works. Examples include azole antifungals (such as itraconazole), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John’s wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

This product can affect the results of certain lab tests. Make sure laboratory personnel and all your doctors know you use this drug.

Does ESTROGEN-METHYLTESTOSTERONE interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting, unusual vaginal bleeding.

Do not share this medication with others. Regular complete physical exams which include lab and/or medical tests (such as blood pressure, breast exam/mammogram, pelvic exam, Pap smear) should be done while you are taking this medication. Follow your doctor’s instructions for examining your breasts, and report any lumps right away. Keep all medical and lab appointments. Consult your doctor for more details.

Lifestyle changes (such as reducing stress, eating a low fat/low salt diet, losing weight if you are overweight) to control or prevent high blood pressure, high cholesterol, and diabetes help to prevent heart disease and strokes. Keep your mind active with mental exercises to help prevent dementia. Discuss with your doctor lifestyle changes that might benefit you.

You can also manage hot flashes by keeping a cool body temperature (such as by using a fan, drinking cool beverages, dressing lightly/in layers, avoiding hot/spicy foods). Limiting caffeine and alcohol, exercising regularly, and learning relaxation techniques may help reduce hot flashes. Vaginal lubricants can help lessen discomfort during intercourse.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

esterified estrogens-methyltestosterone 0.625 mg-1.25 mg tablet

Color: light greenShape: oblongImprint: 1507

This medicine is a light green, oblong, sugar-coated, tablet imprinted with “1507”.

esterified estrogens-methyltestosterone 1.25 mg-2.5 mg tablet

Color: light greenShape: oblongImprint: SYNTHO 231

This medicine is a light green, oblong, sugar-coated, tablet imprinted with “1507”.

esterified estrogens-methyltestosterone 0.625 mg-1.25 mg tablet

Color: light blueShape: oblongImprint: SYNTHO 230

This medicine is a light green, oblong, sugar-coated, tablet imprinted with “1507”.

esterified estrogens-methyltestosterone 1.25 mg-2.5 mg tablet

Color: dark greenShape: oblongImprint: 1490

This medicine is a light green, oblong, sugar-coated, tablet imprinted with “1507”.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Estrogens (Esterified) and Methyltestosterone | Memorial Sloan Kettering Cancer Center

Adult Medication

This information from Lexicomp^® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: US

Covaryx; Covaryx HS; EEMT; EEMT HS; Est Estrogens-Methyltest DS; Est Estrogens-Methyltest HS

Warning

• Estrogens may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to the doctor.
• Do not use estrogens to prevent heart disease or dementia. Using estrogens may raise the chances of having a heart attack, a stroke, breast cancer, ovarian cancer, a blood clot, or dementia.
• Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
• This drug may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking this drug, call your doctor right away.

What is this drug used for?

• It is used to prevent or lower the signs of the change of life (menopause).
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

• If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have had any of these health problems: Bleeding disorder, blood clots, a higher risk of having a blood clot, breast cancer, liver problems or liver tumor, heart attack, stroke, or a tumor where estrogen makes it grow.
• If you have unexplained vaginal bleeding.
• If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.
• If you are breast-feeding. Do not breast-feed while you take this drug.

This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

• Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
• If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
• High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• Be sure to have regular breast exams and gynecology check-ups. You will also need to do breast self-exams as you have been told.
• This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug.
• Limit your drinking of alcohol.
• Avoid cigarette smoking. Smoking raises the chance of heart disease. Talk with your doctor.
• If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
• This drug may raise the chance of blood clots, a stroke, or a heart attack. Talk with the doctor.
• Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
• This drug may cause high cholesterol and triglyceride levels. Talk with the doctor.
• This drug may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
• High calcium levels have happened with drugs like this one in some people with cancer. Call your doctor right away if you have signs of high calcium levels like weakness, confusion, feeling tired, headache, upset stomach or throwing up, constipation, or bone pain.
• If you are 65 or older, use this drug with care. You could have more side effects.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of gallbladder problems like pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; fever with chills; bloating; or very upset stomach or throwing up.
• Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
• Signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
• Dizziness or passing out.
• Eyesight changes or loss, bulging eyes, or change in how contact lenses feel.
• A lump in the breast, breast pain or soreness, or nipple discharge.
• Vaginal itching or discharge.
• Vaginal bleeding that is not normal.
• Depression or other mood changes.
• Memory problems or loss.
• For females, a deep voice, facial hair, pimples, or period changes.
• Enlarged clitoris.
• This drug may cause you to swell or keep fluid in your body. Tell your doctor if you have swelling, weight gain, or trouble breathing.
• Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache.
• Upset stomach or throwing up.
• Stomach cramps.
• Bloating.
• Hair loss.
• Tender breasts.
• Enlarged breasts.
• Vaginal bleeding or spotting.
• Change in sex interest.
• Weight gain or loss.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take this drug at the same time of day.
• There may be days when you will not take this drug.
• Take with or without food. Take with food if it causes an upset stomach.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

• Store at room temperature in a dry place. Do not store in a bathroom.
• Store this drug in a safe place where children cannot see or reach it, and where other people cannot get to it. A locked box or area may help keep this drug safe. Keep all drugs away from pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else’s drugs.
• Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last Reviewed Date

2020-03-03

Copyright

© 2023 UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.

Last Updated

Monday, December 12, 2022

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• Weight problems
• VIP examinations
• Respiratory diseases
• Aller hyia
• Determination of micronutrient reserves in the body
• Beauty
• Vitamins
• Diets
• Lab tests before diet
• Sports profiles
• Hormonal tests for men
• Depression
• Laboratory tests for medical information

• • Biochemical tests
    • Glucose and carbohydrate metabolism metabolites
    • Proteins and amino acids
    • Bile pigments and acids
    • Lipids
    • Enzymes
    • Renal function markers
    • Inorganic substances/electrolytes:
    • Vitamins
    • Proteins involved in iron metabolism
    • Cardiospecific proteins
    • Markers of inflammation
    • Markers of bone metabolism and osteoporosis
    • Drug and psychoactive substance detection
    • Biogenic amines
    • Specific proteins

    9 0011

    • Hormonal studies
      • Laboratory evaluation of the pituitary-adrenal system
      • Laboratory evaluation somatotropic function of the pituitary gland
      • Laboratory assessment of thyroid function
      • Assessment of parathyroid function
      • Pituitary gonadotropic hormones and prolactin
      • Estrogens and progestins
      • Assessment of androgenic function
      • Non-steroidal regulatory factors of the gonads
      • Monito Pregnancy ring, biochemical markers of fetal condition
      • Laboratory evaluation of pancreatic endocrine function and diagnosis of diabetes
      • Biogenic amines
      • Laboratory evaluation of the renin-angiotensin-aldosterone system
      • Factors involved in the regulation of appetite and fat metabolism
      • Laboratory assessment of the endocrine function of the gastrointestinal tract
      • Laboratory assessment of the hormonal regulation of erythropoiesis
      • Laboratory assessment of the pineal gland function

    9 0009 Healthy lifestyle tests

    • Hematological tests
      • Clinical tests blood tests
      • Immunohematological studies
      • Coagulological studies (coagulogram)
    • Immunological studies
      • Comprehensive immunological studies
      • Lymphocytes, subpopulations
      • Phagocytosis assessment
      • Immunoglobulins
      • Complement components 9 0004
      • Regulators and mediators of immunity
      • Interferon status, assessment of sensitivity to immunotherapeutic drugs:
    • Allergological studies
      • IgE – allergen-specific (allergy tests), mixtures, panels, total IgE.
      • IgG, allergen-specific
      • ImmunoCAP technology
      • AlcorBio technology
      • ALEX technology
    • Autoimmune disease markers
      • Systemic connective tissue diseases
      • Rheumatoid arthritis, joint disorders
      • Antiphospholipid syndrome
      • Vasculitis and kidney disorders
      • Autoimmune lesions of the gastrointestinal tract. Celiac disease
      • Autoimmune liver disease
      • Neurological autoimmune diseases
      • Autoimmune endocrinopathies
      • Autoimmune skin diseases
      • Lung and heart diseases
      • Immune thrombocytopenia

    9 0009 Tumor markers

    • COVID-19
    • Trace elements
      • Aluminum
      • Barium
      • Beryllium
      • Boron
      • Vanadium
      • Bismuth
      • Tungsten
      • Gallium
      • Germanium
      • Iron
      • Gold
      • Iodine
      • Cadmium
      • Potassium
      • Calcium
      • Cobalt
      • Silicon
      • Lanthanum
      • Lithium
      • Magnesium
      • Manganese
      • Copper
      • Molybdenum
      • Arsenic
      • Sodium
      • Nickel
      • Tin
      • Platinum
      • Mercury
      • Rubidium
      • Lead
      • Selenium
      • Silver
      • Strontium

      900 09Antimony

      • Thallium
      • Phosphorus
      • Chromium
      • Zinc
      • Zirconium
    • Examination of the structure of the kidney stone
    • Urinalysis
      • Clinical analysis of urine
      • Biochemical analysis of urine
    • Examination of feces
      • Clinical analysis of feces
      • Biochemical analysis of feces
    • Sperm examination
      • Light-optical examination of spermatozoa
      • Electron microscopic examination of semen
      • Antisperm antibodies
    • Diagnosis of infectious diseases
      • Viral infections
      • Bacterial infections
      • Fungal infections
      • Parasitic infections
      • Streptococcal infections
    • Cytological studies
    • Histological studies
    • Oncogenetic studies
    • Cytogenetic studies
    • Non-invasive prenatal tests
    • Genetic predispositions
      • Lifestyle and genetic factors
      • Reproductive health
      • Immunogenetics
      • Rh factor
      • Blood coagulation system
      • Diseases of the heart and blood vessels
      • Diseases of the gastrointestinal tract
      • Diseases of the central nervous system
      • Oncological diseases
      • Metabolic disorders
      • Description of the results of genetic studies by a geneticist
      • Pharmacogenetics
      • Xenobiotics and carcinogens detoxification system
      • Fetal sex determination
      • Fetal Rh factor
    • Hereditary diseases
    • Hereditary metabolic diseases
      • Hereditary metabolic diseases
      • Additional studies (after screening and consultation with a specialist )
    • Determination of biological relationship: paternity and motherhood
      • Determination of biological relationship in the family: paternity and motherhood
    • Study of water and soil quality
      • Study of water quality
      • Study of soil quality
    • Diagnosis of liver pathology without biopsy: FibroMax, FibroT eats, SteatoScreen
      • Calculated tests performed according to the results of SteatoScreen without blood sampling
    • Dysbiotic conditions of the intestine and urogenital tract
      • General assessment of the natural microflora of the body
      • Study of the microbiocenosis of the urogenital tract
      • Femoflor: profiles of studies of dysbiotic conditions of the urogenital tract in women
      • Specific assessment of the natural microflora of the body
    • Form of study results in English tongue
  • • blood
    • Urine
    • Feces
    • Spermogram
    • Gastropanel
  • • Endoscopy
    • Functional diagnostics
    • Ultrasound
  • • Examinations we do not do
    • New tests
    • Getting results
    • Additional examinations
    • Consultant physician service
    • Professional item
      • Venous blood for analysis
      • Tumor markers. View of a practical oncologist. Laboratory justifications.
      • Testosterone: diagnostic threshold, method-dependent reference values ​​
      • Laboratory assessment of lipid parameters in INVITRO
      • Lipid profile: fasting or not fasting

  The cost of analyzes is indicated without taking biomaterial

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  When choosing where to perform estrogens and progestins in Moscow and other cities of Russia, do not forget that the cost, methods and terms of performing studies in regional medical offices may differ

  Tests to detect early signs of sex hormone deficiency in yourself

  Tests to detect early signs of sex hormone deficiency in yourself

  Modern women do not want to grow old, they want to look good and give birth after 40 and even 45, while being cheerful and maintaining sexual desire, health and beauty.

  Therefore, we will be very relevant several tests to determine the early signs of a deficiency of sex hormones.

  The test is called “when to sound the alarm”

  Estrogen deficiency testing:

  1. My hair is thinning on my head
  2. I have wrinkles around my lips
  3. I have saggy breasts
  4. My face has started to grow hair
  5. I suffer from dry eyes and they are easily irritated
  6. I sometimes experience hot flashes
  7. I constantly feel tired
  8. I am constantly depressed
  9. I have light menstrual flow
  10. My cycle is too short, less than 27 days or too long 31 days
  11. I no longer feel sexual desire.

  Rating:
  0 points – never
  1 – very rare
  2 – moderately
  3 – often
  4 – almost constantly

  Interpretation:
  10 points or less – good estrogen level
  10-20 points – lack of estrogen is likely
  20 points or more – there is a deficiency of estrogen

  Testing for progesterone deficiency (may be on its own, without estrogen deficiency):

  1. I have breast engorgement
  2. My family and friends notice my nervous and agitated behavior
  3. I feel anxious
  4. I have a bad and restless sleep
  5. Before a cycle, the mammary glands increase in size and become painful
  6. I have an increase in the lower part of the abdomen (under the navel)
  7. I became irritable and aggressive
  8. I’m losing my temper
  9. I have excessively heavy periods
  10. Menstrual cycles are painful

  Rating:
  0 points – never
  1 – very rare
  2 – moderately
  3 – often
  4 – almost always

  Interpretation:
  10 points or less – a good level of progesterone
  10-20 points – lack of progesterone is likely
  20 points or more – progesterone deficiency is

  Now we look in the mirror: – “My light, mirror, say . ……”
  The eyes shine, the hair is thick and not dry, the oval of the face “does not fall”, there are no wrinkles around the mouth (“muslin mouth”;), the skin has good turgor and is not dry (without areas of peeling and irritation), there is no dryness and redness of the mucous membrane of the eyes, no periodontal disease, no hyperpigmentation of the skin and swelling of the face – no estrogen / progesterone deficiency.

  Mirror test:

  Add 20 to the number, more points if you have:
  wrinkles between the eyebrows +4
  wrinkles under gases +5
  drooping of the upper eyelid+5
  “bags under the eyes”+5
  “crow’s feet”+5
  wrinkles on the lips+6
  age spots+6
  wrinkles around lips +6
  pronounced nasolabial fold+4
  double chin +5
  neck wrinkles +6
  weakened oval face +6

  total points = your skin age, if it is more than your passport age – you have an estrogen deficiency!

  The following test, let’s call it the “palm test” / or it is called the “pinch test”:

  On the back of the hand (any) fold the skin for a few seconds
  (applying pressure), see in how many seconds, how fast! the skin fold will straighten out.
  1. normal, without estrogen deficiency, the wrinkle straightens out immediately – it means you and your skin are 25-30 years old
  2. the crease straightened out in 5 seconds – you are 30-40 physically
  3. the crease straightened out in 8 seconds – you are physically 40-50
  4. the crease straightened out in 8 or more seconds – you are over 50 years old physically

  And another very test for estrogen deficiency (this is the determination of estrogen deficiency in the vagina using the pH test strip method), more often it is clinically expressed by dryness of the vulva, an increase in cystitis and their relapses. You can take this test at our clinic by making an appointment with a gynecologist.

  You can also conduct an assessment of estrogen and androgen deficiency in the laboratory at our clinic “County Doctor” at a convenient time for you. Our specialists will evaluate the results of the examination and provide individual recommendations.