Fatigue runny nose. Omicron Variant Symptoms: Runny Nose, Headache, and Fatigue Dominate Early Data
What are the most common symptoms of the Omicron variant. How do Omicron symptoms differ from previous Covid-19 variants. Why are health experts calling for updated symptom lists. What should the public know about identifying potential Omicron infections.
Key Symptoms of Omicron: What the Latest Data Reveals
Recent data from the Covid Symptoms Study, conducted by Zoe and King’s College London, has shed light on the most prevalent symptoms associated with the Omicron variant. This information is crucial for public awareness and early detection of potential infections.
The top five reported symptoms for Omicron infection are:
- Runny nose
- Headache
- Fatigue (mild or severe)
- Sneezing
- Sore throat
These findings are based on positive cases in London, chosen for its higher prevalence of Omicron compared to other parts of the UK. The data suggests a shift in symptom presentation compared to earlier variants of the virus.

Comparing Omicron to Delta: Are There Significant Differences?
To understand how Omicron differs from its predecessor, researchers compared data from two distinct periods:
- A week when Delta was dominant (363 cases from October 3-10, 2021)
- Recent data reflecting Omicron’s prevalence (847 cases from December 3-10, 2021)
Initial analysis found no clear distinctions between Delta and Omicron in the early stages of infection (within three days of testing). However, the overall symptom profile appears to have shifted, with Omicron presenting more cold-like symptoms.
The Call for Updated Symptom Lists: Why It Matters
Health experts, including Tim Spector, lead scientist on the Zoe Covid Study app, are urging the UK government to revise its official list of Covid-19 symptoms. The current list, which includes fever, cough, and loss of sense of smell or taste, primarily reflects symptoms associated with the Alpha variant.
Why is updating the symptom list crucial?
- It helps the public identify potential infections more accurately
- It encourages appropriate isolation and testing measures
- It aligns with international guidelines that have already been updated
Spector emphasizes the importance of public awareness, stating, “If you do have symptoms of a mild or bad cold, it’s highly likely that you’ve got covid if you’re in an area like London at the moment.”
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International Perspectives: How Other Countries Are Adapting
The UK’s approach to Covid-19 symptom guidance appears to be an outlier on the international stage. Several major health organizations and countries have already updated their symptom lists to reflect the evolving nature of the virus:
- US Centers for Disease Control and Prevention (CDC)
- World Health Organization (WHO)
- European countries such as Spain and France
These updates typically include a broader range of symptoms, including those commonly associated with colds and flu. This approach aims to capture a wider net of potential cases and encourage appropriate testing and isolation measures.
The Impact of Nasal Congestion: Beyond Covid-19
While the focus is currently on Covid-19 symptoms, it’s worth noting that nasal congestion can have significant impacts on overall health and well-being. A 2002 review published in the American Journal of Respiratory Medicine highlighted the relationship between allergic rhinitis, nasal congestion, and sleep quality.

Key findings from this review include:
- Nasal congestion can lead to poor sleep quality
- Daytime somnolence (excessive sleepiness) is common in individuals with allergic rhinitis
- The impact of nasal congestion on sleep can affect overall quality of life
This research underscores the importance of addressing nasal symptoms, whether they’re related to Covid-19, allergies, or other respiratory conditions.
Public Health Implications: Navigating the Changing Landscape
As the Omicron variant continues to spread, public health strategies must adapt to the changing nature of the virus. The shift in symptom presentation poses both challenges and opportunities for containment efforts.
What are the key public health implications of Omicron’s symptom profile?
- Increased need for public education on recognizing potential Covid-19 symptoms
- Potential for higher transmission rates due to symptoms mimicking common colds
- Importance of maintaining precautionary measures, even with mild cold-like symptoms
- Need for accessible testing to differentiate between Covid-19 and other respiratory infections
Public health officials and healthcare providers must work together to disseminate accurate, up-to-date information to help individuals make informed decisions about their health and potential exposure risks.

The Role of Vaccination in Symptom Mitigation
While the Omicron variant has shown an ability to evade some vaccine-induced immunity, vaccination still plays a crucial role in mitigating severe symptoms and reducing hospitalization rates. As the virus evolves, so too must our approach to vaccination and booster strategies.
How does vaccination impact Omicron symptoms?
- Vaccinated individuals may experience milder symptoms
- Boosters can enhance protection against symptomatic infection
- Ongoing research is necessary to understand the full impact of vaccination on Omicron
It’s important to note that while vaccinated individuals may experience milder symptoms, they can still transmit the virus to others. This underscores the continued importance of testing and isolation, even for those who are fully vaccinated.
Looking Ahead: The Future of Covid-19 Symptom Tracking
As the Covid-19 pandemic continues to evolve, so too must our approaches to symptom tracking and disease management. The emergence of the Omicron variant highlights the need for flexible, responsive public health strategies that can adapt to new challenges.

What might the future hold for Covid-19 symptom tracking?
- Increased use of digital health technologies for real-time symptom reporting
- Development of more sophisticated AI algorithms to predict outbreaks based on symptom clusters
- Greater integration of symptom data with genomic sequencing to track variant spread
- Enhanced collaboration between international health organizations for standardized symptom reporting
As we navigate this new phase of the pandemic, it’s crucial that individuals, healthcare providers, and policymakers remain vigilant and adaptable. By staying informed about the latest symptom profiles and following public health guidelines, we can collectively work towards managing the spread of Covid-19 and its variants.
The Importance of Continued Research and Data Collection
The evolving nature of the SARS-CoV-2 virus underscores the critical need for ongoing research and data collection. As new variants emerge, our understanding of the virus’s behavior, transmission patterns, and symptom profiles must be continuously updated.

What are the key areas of focus for future Covid-19 research?
- Long-term effects of different variants on human health
- Impact of vaccination on symptom severity and duration
- Potential for seasonal variations in symptom presentation
- Development of more targeted treatments based on specific symptom profiles
By investing in robust research initiatives and fostering global scientific collaboration, we can enhance our ability to respond effectively to future challenges posed by Covid-19 and other emerging infectious diseases.
The Role of Public Communication in Managing Omicron
Clear, consistent, and timely communication is essential in managing public response to the Omicron variant. As symptom profiles shift and new data emerges, it’s crucial that health authorities and media outlets work together to disseminate accurate information.
How can effective public communication help manage the Omicron wave?
- Reduce confusion about which symptoms warrant testing and isolation
- Encourage appropriate healthcare-seeking behavior
- Combat misinformation and conspiracy theories
- Foster public trust in health authorities and scientific recommendations
By prioritizing transparent, evidence-based communication strategies, we can empower individuals to make informed decisions about their health and contribute to broader public health efforts.

Adapting Healthcare Systems to Omicron’s Challenges
The shift in symptom presentation associated with Omicron poses new challenges for healthcare systems worldwide. Hospitals, clinics, and testing centers must adapt their protocols to effectively triage and manage patients presenting with a wide range of symptoms.
What changes might healthcare systems need to implement?
- Enhanced triage protocols to differentiate between Covid-19 and other respiratory infections
- Increased capacity for rapid testing in primary care settings
- Development of telemedicine platforms for initial symptom assessment
- Training for healthcare workers on recognizing atypical Covid-19 presentations
By proactively adapting to the changing landscape of Covid-19 symptoms, healthcare systems can improve their ability to provide timely, appropriate care while minimizing the risk of transmission within medical facilities.
The Intersection of Omicron and Other Respiratory Conditions
The cold-like symptoms associated with Omicron raise important questions about the interaction between Covid-19 and other respiratory conditions. As we enter cold and flu seasons, distinguishing between these illnesses becomes increasingly challenging.

What are the implications of Omicron’s symptom profile for managing other respiratory conditions?
- Potential for misdiagnosis or delayed diagnosis of non-Covid respiratory infections
- Increased importance of comprehensive testing for multiple pathogens
- Need for public education on differentiating between Covid-19, colds, and flu
- Possible changes in treatment protocols for respiratory symptoms of unknown origin
Healthcare providers and public health officials must navigate this complex landscape to ensure that all respiratory conditions receive appropriate attention and treatment, even as Covid-19 remains a primary concern.
The Global Impact of Omicron’s Symptom Profile
As Omicron spreads globally, its distinct symptom profile has far-reaching implications for international travel, economic recovery, and global health policies. The more subtle nature of Omicron symptoms could potentially lead to increased transmission across borders if not properly managed.
How might Omicron’s symptom profile affect global efforts to contain the pandemic?

- Challenges in implementing effective travel screening measures
- Need for harmonized international guidelines on symptom recognition and testing
- Potential impact on global supply chains due to workforce disruptions
- Increased importance of global genomic surveillance to track variant spread
As the world continues to grapple with the Covid-19 pandemic, international cooperation and coordinated response efforts become ever more critical in managing the challenges posed by new variants like Omicron.
Covid-19: Runny nose, headache, and fatigue are commonest symptoms of omicron, early data show
News
BMJ
2021;
375
doi: https://doi.org/10.1136/bmj.n3103
(Published 16 December 2021)
Cite this as: BMJ 2021;375:n3103
Read our latest coverage of the coronavirus pandemic
- Gareth Iacobucci
- The BMJ
The UK government has been urged to update its list of symptoms for covid-19, after early data showed that cold-like symptoms were the most commonly reported by people with the new omicron variant.
Data released on 16 December by the Covid Symptoms Study,1 run by the health science company Zoe and King’s College London, show that the top five symptoms reported in the app for omicron infection were runny nose, headache, fatigue (either mild or severe), sneezing, and sore throat. This initial analysis was based on positive cases in London, which was selected because of its higher prevalence of omicron than in other parts of the UK.
The government still lists fever, cough, and loss of sense of smell or taste—which were the most common with the alpha variant—as the covid symptoms to watch out for.
Tim Spector, lead scientist on the Zoe Covid Study app, who has been calling for the list of symptoms to be updated since the emergence of the delta variant,2 said a change was overdue.
“The messaging from the government is just not clear on this,” he said. “I think most people know what cold-like symptoms are. I would probably just add [to the list]: ‘Have you got cold-like symptoms?’ We need to educate people, go back to the basics, and say that if you’ve got cold-like symptoms keep away from people. You shouldn’t be waiting for the three classic symptoms.”
To compare delta and omicron, London data were selected from a week where delta was dominant (a sample of 363 cases from 3-10 October 2021) and compared with the most recent data (847 cases from 3-10 December 2021). This initial analysis found no clear differences between delta and omicron in the early symptoms (three days after testing).
Spector said it was vital that members of the public were aware of the symptoms to look out for, particularly in areas such as London that have very high rates of omicron infection. “If you do have symptoms of a mild or bad cold, it’s highly likely that you’ve got covid if you’re in an area like London at the moment,” he said.
Spector said the UK was now an international exception in not listing cold-like symptoms as likely indicators of covid infection, noting that the US Centers for Disease Control and Prevention, the World Health Organization, and European countries such as Spain and France had all updated their advice.
“The UK is the odd one out,” he said. “They should amend it if the majority are presenting that way.”
The Department of Health and Social Care for England said that the main symptoms listed had been carefully selected to capture the people most likely to have covid-19 while not including a large number of people who did not. A spokesperson said, “Since the start of the pandemic we have acknowledged covid-19 has a much longer list of symptoms than the ones used in the case definition, and experts keep the list of symptoms under review.
”
This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
https://bmj.com/coronavirus/usage
References
- ↵
Omicron and cold-like symptoms rapidly taking over in London. Zoe Covid Study.16 Dec 2021. https://covid.joinzoe.com/post/omicron-and-cold-like-symptoms-rapidly-taking-over-in-london.
- ↵
- Mahase E
. Covid-19: GPs urge government to clear up confusion over symptoms. BMJ2021;373:n1654. doi:10.1136/bmj.n1654 pmid:34183357
Poor sleep and daytime somnolence in allergic rhinitis: significance of nasal congestion
Review
. 2002;1(3):195-200.
doi: 10.
1007/BF03256609.
Sujani Kakumanu
1
, Casey Glass, Timothy Craig
Affiliations
Affiliation
- 1 Department of Medicine, Pulmonary, Allergy, Critical Care, Hershey, Pennsylvania 17033, USA.
PMID:
14720057
DOI:
10.1007/BF03256609
Review
Sujani Kakumanu et al.
Am J Respir Med.
2002.
. 2002;1(3):195-200.
doi: 10.1007/BF03256609.
Authors
Sujani Kakumanu
1
, Casey Glass, Timothy Craig
Affiliation
- 1 Department of Medicine, Pulmonary, Allergy, Critical Care, Hershey, Pennsylvania 17033, USA.

PMID:
14720057
DOI:
10.1007/BF03256609
Abstract
Patients with allergic rhinitis frequently present with symptoms of nasal congestion, runny nose, sneezing, daytime somnolence and fatigue associated with decreased cognitive performance and impaired quality of life. Recent research has suggested that daytime somnolence in allergic rhinitis can be attributed to chronic inflammation of the nasal mucosa leading to nasal congestion and obstructed nasal passageways resulting in disturbed sleep. Treating daytime somnolence due to allergic rhinitis requires a reduction in obstruction caused by nasal congestion. Currently available therapy for allergic rhinitis includes topical corticosteroids, sedating and nonsedating antihistamines, topical cromolyn sodium (sodium cromoglycate), decongestants, immunotherapy and topical ipratropium bromide.
The effectiveness of antihistamines in patients with allergic rhinitis has long been established. However, results of placebo-controlled trials investigating the effects of azelastine on sleep and daytime somnolence have produced conflicting results. Sleep improved with azelastine therapy, but there was a lack of evidence that azelastine significantly affected daytime sleepiness, sleep severity and nasal congestion. Sedating antihistamines exacerbate daytime somnolence and should be avoided in patients with allergic rhinitis. In a separate study, desloratadine failed to benefit sleep, but did not worsen daytime somnolence. Topical nasal cromolyn sodium is inconvenient to use and is unlikely to have a major effect on nasal congestion. Decongestants do decrease nasal congestion but the effect this has on sleep has not been adequately studied. Recent research has shown that topical corticosteroids are an effective treatment for alleviating nasal congestion secondary to allergic rhinitis. However, few studies have assessed the effect of topical corticosteroids on daytime fatigue and sleep.
In 20 patients with allergic rhinitis and symptoms of daytime sleepiness, flunisolide significantly improved sleep quality and congestion but daytime sleepiness was not significantly improved. A similar study with fluticasone propionate showed improvement in nasal congestion and sleep but there was no significant change in objective sleep measurements recorded on polysomnography. Further research involving objective measures of sleep quality is necessary to determine the efficacy of medications in the treatment of allergic rhinitis associated with fatigue and daytime somnolence.
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Fatigue syndrome or common SARS: what can be confused with “omicron”
The symptoms inherent in “omicron”, such as headache and chronic fatigue, may indicate other diseases, immunologists told Gazeta.Ru. In particular, the manifestations of a new strain of coronavirus are similar to influenza or rhinovirus, as well as chronic fatigue syndrome, which many patients suffer in the autumn-winter period.
The first patients infected with the new strain of omicron coronavirus complained of severe fatigue and headaches.
Angelique Coetzee, a doctor from the Republic of South Africa, told The Telegraph about this. She was the first to report patients with a new variant of the virus.
According to the specialist, suspicions that the pathogen has mutated again arose due to the increased visits of patients with unusual manifestations of COVID-19. In particular, these were young people complaining of a strong feeling of fatigue and headaches, as well as a six-year-old child with a rapid pulse and a high temperature – while two days later he felt better.
It is noted that none of the patients experienced loss of taste or smell. “Their symptoms were very different from those that I had experienced before, and manifested in a mild form,” she noted.
In total, about two dozen Coetzee patients with symptoms of a new type of infection have tested positive for COVID-19.
“Information about the symptoms of” omicron “appeared for the first time from South Africa, in particular, doctor Coetzee gave an assessment of working with 20 patients.
All were young without any serious illnesses and, naturally, they all got sick easily. Based on this, she concluded that the new strain only affects the young and those with symptoms of headache and fatigue. But this is not even a study, but a description of several cases, ”said Nikolai Kryuchkov, candidate of medical sciences, immunologist, in an interview with Gazeta.Ru.
The fact is that weakness and headache are typical symptoms of any type of SARS, they arise due to the production of inflammatory mediators, explained immunologist Maria Polner.
“COVID-19 can affect any organs and systems and lead to an exacerbation of chronic diseases. The new variant of the virus is no exception. Indeed, it is known that there are features of the clinical manifestations of different variants of the virus, but the severity of the course, as well as the consequences of the new version of Omicron, are still being studied, ”she said.
Kryuchkov agreed with her. According to him, any signs of an acute condition – a runny nose, sore throat, headaches, severe fatigue – may indicate both a coronavirus and another infection.![]()
“Based on clinical signs, coronavirus is quite easy to confuse with other SARS. Although it may be SARS, which this season will be much more than last. Rhinovirus, influenza and adenovirus – all these symptoms will be, ”he added.
Headache and severe fatigue are also indicative of chronic fatigue syndrome, which many people suffer from when cold weather sets in, explained Irina Ivanova, general practitioner.
“In conditions of late autumn and early winter with extremely low levels of insolation, it will be very difficult to suspect infection with a new strain of coronavirus. For young, working and studying people at this time of the year, chronic fatigue syndrome is very typical. And they are trying to present this complaint to us as characteristic of a new mutation, ”the specialist emphasized.
It is already known that Omicron, like Delta, is highly contagious due to the fact that most of its mutations are in the spike protein (S-protein).
“In addition, there are big concerns that it can bypass both the antibodies formed as a result of vaccination and the antibodies that form after the illness.
That is, it is quite possible to get coronavirus of different genetic variants twice in a row. Of course, a lot depends on the amount of ready-made antibodies at the time of infection, as well as on the number of viral units that have entered,” Polner said.
In this regard, the assertion that only young people aged 20-30 years are subject to the “omicron”, as South African scientists previously stated, is not tenable.
“In those countries where the population is older, the average age is higher, where there are many elderly, unlike South Africa, the new strain of coronavirus will behave, I think, like the “delta,” Kryuchkov said.
According to the immunologist, “omicron” appeared as a result of a spontaneous mutation of the coronavirus in a human body with an advanced form of immunodeficiency.
“There was a bit of a glitch, because in fact, in an immunodeficient untreated patient with HIV infection, this virus mutated for several months and grew to an “omicron”.
Moreover, apparently, the patient was close to AIDS – he contracted the coronavirus, and maybe two strains at once. Therefore, this strain is unusual and very different from the delta. This conclusion can be drawn due to the fact that there are no intermediate links in the development of a new strain. That is, where did it come from in the population,” Kryuchkov concluded.
Fatigue, runny nose and headache are called early symptoms of “omicron”
Fatigue, runny nose and headache are called early symptoms of “omicron”
A sore throat, runny nose, fatigue and headache may be early signs of infection with the omicron strain of coronavirus. You should also pay attention to body aches, sneezing and night sweats.
This was stated by scientists from the UK, US and South Africa, writes the British newspaper Express. The conclusions of the doctors in an interview with RBC were confirmed by the director of the Center for the Global Virological Network Konstantin Chumakov.
He noted that the incubation period of the virus has been markedly reduced. A person gets sick very quickly – 2-3 days after infection. The symptoms of the omicron strain are very difficult to distinguish from the common cold.
Previously, the St. Petersburg TV channel reported that more than two hundred cases of the VA.2 subspecies were detected in Russia – more contagious than the original version. The fact that a new version of Omicron has come to Russia was announced on February 2 by the head of Rospotrebnadzor Anna Popova.
Photo: St. Petersburg TV channel
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2000 Jul;85(1):53-7. doi: 10.1016/S1081-1206(10)62434-9.
2003.
